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Krishnamurthy, Ramanarayanan
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Krishnamurthy, Ramanarayanan

Faculty Member
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Positions

  • 2013 - Associate Professor of Chemistry, Chemistry , Scripps Research
  • - 2013 Associate Professor, Chemistry , Scripps Research
Dr. Ramanarayanan Krishnamurthy seeks to examine the question of why nature selected the building blocks it did to make RNA and uses chemical reasoning to conceive, synthesize, and study alternative nucleic acid structures, like TNA, that could have assembled themselves under natural conditions.

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  • rkrishna@scripps.edu

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  • Ramanarayanan Krishnamurthy, Ph.D.
  • Krishnamurthy Laboratory
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Publications

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  • 30

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    • Toparlak, O. D., Karki, M., Ortuno, V. E., Krishnamurthy, R., Mansy, S. S. Cyclophospholipids increase protocellular stability to metal ions Small  2020  DOI:10.1002/smll.201903381  PMID:31523894
    • Frenkel-Pinter, M., Haynes, J. W., Mohyeldin, A. M., Martin, C., Sargon, A. B., Petrov, A. S., Krishnamurthy, R., Hud, N. V., Williams, L. D., Leman, L. J. Mutually stabilizing interactions between proto-peptides and RNA Nature Communications  2020 11  DOI:10.1038/s41467-020-16891-5  PMID:32561731  PMCID:PMC7305224
    • Yadav, M., Kumar, R., Krishnamurthy, R. Chemistry of Abiotic Nucleotide Synthesis Chemical Reviews  2020 120:4766-4805  DOI:10.1021/acs.chemrev.9b00546  PMID:31916751
    • Krishnamurthy, R., Hud, N. V. Introduction: Chemical Evolution and the Origins of Life Chemical Reviews  2020 120:4613-4615  DOI:10.1021/acs.chemrev.0c00409  PMID:32517476
    • Fischer, E. C., Hashimoto, K., Zhang, Y., Feldman, A. W., Dien, V. T., Karadeema, R. J., Adhikary, R., Ledbetter, M. P., Krishnamurthy, R., Romesberg, F. E. New codons for efficient production of unnatural proteins in a semisynthetic organism Nature Chemical Biology  2020 16:570-576  DOI:10.1038/s41589-020-0507-z  PMID:32251411
    • Ledbetter, M. P., Craig, J. M., Karadeema, R. J., Noakes, M. T., Kim, H. C., Abell, S. J., Huang, J. R., Anderson, B. A., Krishnamurthy, R., Gundlach, J. H., Romesberg, F. E. Nanopore sequencing of an expanded genetic alphabet reveals high-fidelity replication of a predominantly hydrophobic unnatural base pair Journal of the American Chemical Society  2020 142:2110-2114  DOI:10.1021/jacs.9b09808  PMID:31985216
    • Stubbs, R. T., Yadav, M., Krishnamurthy, R., Springsteen, G. A plausible metal-free ancestral analogue of the Krebs cycle composed entirely of α-ketoacids Nature Chemistry  2020 12:1016-1022  DOI:10.1038/s41557-020-00560-7
    • Parker, E. T., Karki, M., Glavin, D. P., Dworkin, J. P., Krishnamurthy, R. A sensitive quantitative analysis of abiotically synthesized short homopeptides using ultraperformance liquid chromatography and time-of-flight mass spectrometry Journal of Chromatography A  2020 1630  DOI:10.1016/j.chroma.2020.461509  PMID:32927393
    • McKenna, K. R., Li, L., Baker, A. G., Ujma, J., Krishnamurthy, R., Liotta, C. L., Fernandez, F. M. Carbohydrate isomer resolution via multi-site derivatization cyclic ion mobility-mass spectrometry Analyst  2019 144:7220-7226  DOI:10.1039/c9an01584a  PMID:31670330
    • Li, Z., Li, L., McKenna, K. R., Schmidt, M., Pollet, P., Gelbaum, L., Fernandez, F. M., Krishnamurthy, R., Liotta, C. L. The oligomerization of glucose under plausible prebiotic conditions Origins of Life and Evolution of Biospheres  2019  DOI:10.1007/s11084-019-09588-3  PMID:31792744
    • Bhowmik, S., Krishnamurthy, R. The role of sugar-backbone heterogeneity and chimeras in the simultaneous emergence of RNA and DNA Nature Chemistry  2019 11:1009-1018  DOI:10.1038/s41557-019-0322-x  PMID:31527850  PMCID:PMC6815252
    • Yadav, M., Krishnamurthy, R. Bis(dimethylamino)phosphorodiamidate: a reagent for the regioselective cyclophosphorylation of cis-diols enabling one-step access to high-value target cyclophosphates Organic Letters  2019 21:7400-7404  DOI:10.1021/acs.orglett.9b02694  PMID:31469285
    • Castaneda, A. D., Li, Z., Joo, T., Benham, K., Burcar, B. T., Krishnamurthy, R., Liotta, C. L., Ng, N. L., Orlando, T. M. Prebiotic phosphorylation of uridine using diamidophosphate in aerosols Scientific Reports  2019 9  DOI:10.1038/s41598-019-49947-8  PMID:31537885  PMCID:PMC6753121
    • Frenkel-Pinter, M., Haynes, J. W., Martin, C., Petrov, A. S., Burcar, B. T., Krishnamurthy, R., Hud, N. V., Leman, L. J., Williams, L. D. Selective incorporation of proteinaceous over nonproteinaceous cationic amino acids in model prebiotic oligomerization reactions Proceedings of the National Academy of Sciences of the United States of America  2019 116:16338-16346  DOI:10.1073/pnas.1904849116  PMID:31358633  PMCID:PMC6697887
    • Feldman, A. W., Dien, V. T., Karadeema, R. J., Fischer, E. C., You, Y., Anderson, B. A., Krishnamurthy, R., Chen, J. S., Li, L., Romesberg, F. E. Optimization of replication, transcription, and translation in a semi-synthetic organism Journal of the American Chemical Society  2019 141:10644-10653  DOI:10.1021/jacs.9b02075  PMID:31241334
    • Gibard, C., Gorrell, I. B., Jimenez, E. I., Kee, T. P., Pasek, M. A., Krishnamurthy, R. Geochemical sources and availability of amidophosphates on the early earth Angewandte Chemie-International Edition  2019 58:8151-8155  DOI:10.1002/anie.201903808  PMID:30989779
    • Xu, J., Green, N. J., Gibard, C., Krishnamurthy, R., Sutherland, J. D. Prebiotic phosphorylation of 2-thiouridine provides either nucleotides or DNA building blocks via photoreduction Nature Chemistry  2019 11:457-462  DOI:10.1038/s41557-019-0225-x  PMID:30936523
    • Krishnamurthy, R. Experimentally investigating the origin of DNA/RNA on early Earth Nature Communications  2018 9  DOI:10.1038/s41467-018-07212-y  PMID:30538231  PMCID:PMC6290018
    • Ward, G., Liotta, C. L., Krishnamurthy, R., France, S. Base-mediated cascade aldol addition and fragmentation reactions of dihydroxyfumaric acid and aromatic aldehydes: controlling chemodivergence via choice of base, solvent, and substituents Journal of Organic Chemistry  2018 83:14219-14233  DOI:10.1021/acs.joc.8b01867  PMID:30223647
    • Krishnamurthy, R. Life's biological chemistry: a destiny or destination starting from prebiotic chemistry? Chemistry-a European Journal  2018 24:16708-16715  DOI:10.1002/chem.201801847  PMID:29870593
    • Efthymiou, T., Gavette, J., Stoop, M., De Riccardis, F., Froeyen, M., Herdewijn, P., Krishnamurthy, R. Chimeric XNA: an unconventional design for orthogonal informational systems Chemistry-a European Journal  2018 24:12811-12819  DOI:10.1002/chem.201802287  PMID:29901248
    • Yadav, M., Liotta, C. L., Krishnamurthy, R. Effect of temperature modulations on TEMPO-mediated regioselective oxidation of unprotected carbohydrates and nucleosides Bioorganic & Medicinal Chemistry Letters  2018 28:2759-2765  DOI:10.1016/j.bmcl.2018.01.066  PMID:29433926
    • Anderson, B. A., Krishnamurthy, R. Heterogeneous pyrophosphate-linked DNA-oligonucleotides: aversion to DNA but affinity for RNA Chemistry-a European Journal  2018 24:6837-6842  DOI:10.1002/chem.201800538  PMID:29532524
    • Fialho, D. M., Clarke, K. C., Moore, M. K., Schuster, G. B., Krishnamurthy, R., Hud, N. V. Glycosylation of a model proto-RNA nucleobase with non-ribose sugars: implications for the prebiotic synthesis of nucleosides Organic & Biomolecular Chemistry  2018 16:1263-1271  DOI:10.1039/c7ob03017grsc.li/obc  PMID:29308815
    • Li, L., McKenna, K. R., Li, Z., Yadav, M., Krishnamurthy, R., Liotta, C. L., Fernandez, F. M. Rapid resolution of carbohydrate isomers via multi-site derivatization ion mobility-mass spectrometry Analyst  2018 143:949-955  DOI:10.1039/c7an01796k  PMID:29367994
    • Gibard, C., Bhowmik, S., Karki, M., Kim, E. K., Krishnamurthy, R. Phosphorylation, oligomerization and self-assembly in water under potential prebiotic conditions Nature Chemistry  2018 10:212-217  DOI:10.1038/nchem.2878  PMID:29359747
    • Springsteen, G., Yerabolu, J. R., Nelson, J., Rhea, C. J., Krishnamurthy, R. Linked cycles of oxidative decarboxylation of glyoxylate as protometabolic analogs of the citric acid cycle Nature Communications  2018 9  DOI:10.1038/s41467-017-02591-0  PMID:29311556  PMCID:PMC5758577
    • Yu, S. S., Solano, M. D., Blanchard, M. K., Soper-Hopper, M. T., Krishnamurthy, R., Fernandez, F. M., Hud, N. V., Schork, F. J., Grover, M. A. Elongation of model prebiotic proto-peptides by continuous monomer feeding Macromolecules  2017 50:9286-9294  DOI:10.1021/acs.macromol.7b01569
    • Conley, M., Mojica, M., Mohammed, F., Chen, K., Napoline, J. W., Pollet, P., Wang, J., Krishnamurthy, R., Liotta, C. L. Reaction of glycine with glyoxylate: Competing transaminations, aldol reactions, and decarboxylations Journal of Physical Organic Chemistry  2017 30  DOI:10.1002/poc.3709
    • Kim, E. K., Martin, V., Krishnamurthy, R. Orotidine-containing RNA: implications for the hierarchical selection (systems chemistry emergence) of RNA Chemistry-a European Journal  2017 23:12668-12675  DOI:10.1002/chem.201702912  PMID:28708927
    • Forsythe, J. G., Petrov, A. S., Millar, W. C., Yu, S. S., Krishnamurthy, R., Grover, M. A., Hud, N. V., Fernandez, F. M. Surveying the sequence diversity of model prebiotic peptides by mass spectrometry Proceedings of the National Academy of Sciences of the United States of America  2017 114:E7652-E7659  DOI:10.1073/pnas.1711631114  PMID:28847940  PMCID:PMC5604043
    • Krishnamurthy, R. Giving rise to life: Transition from prebiotic chemistry to protobiology Accounts of Chemical Research  2017 50:455-459  DOI:10.1021/acs.accounts.6b00470
    • Poudyal, R. R., Nguyen, P. D. M., Lokugamage, M. P., Callaway, M. K., Gavette, J. V., Krishnamurthy, R., Burke, D. H. Nucleobase modification by an RNA enzyme Nucleic Acids Research  2017 45:1345-1354  DOI:10.1093/nar/gkw1199  PMID:28180302
    • Mohammed, F. S., Chen, K., Mojica, M., Conley, M., Napoline, J. W., Butch, C., Pollet, P., Krishnamurthy, R., Liotta, C. L. A plausible prebiotic origin of glyoxylate: nonenzymatic transamination reactions of glycine with formaldehyde Synlett  2017 28:93-97  DOI:10.1055/s-0036-1588657
    • Gherase, D., Hazen, R. M., Krishnamurthy, R., Blackmond, D. G. Mineral-induced enantioenrichment of tartaric acid Synlett  2017 28:89-92  DOI:10.1055/s-0036-1588912
    • Krishnamurthy, R., Snieckus, V. Prebiotic organic chemistry and chemical pre-biology: speaking to the synthetic organic chemists Synlett  2017 28:27-29  DOI:10.1055/s-0036-1589831
    • Rice, G. B., Yerabolu, J. R., Krishnamurthy, R., Springsteen, G. The abiotic oxidation of organic acids to malonate Synlett  2017 28:98-102  DOI:10.1055/s-0036-1588649
    • Yu, S. S., Krishnamurthy, R., Fernandez, F. M., Hud, N. V., Schork, F. J., Grover, M. A. Kinetics of prebiotic depsipeptide formation from the ester-amide exchange reaction Physical Chemistry Chemical Physics  2016 18:28441-28450  DOI:10.1039/c6cp05527c  PMID:27711571
    • Gavette, J. V., Stoop, M., Hud, N. V., Krishnamurthy, R. RNA-DNA chimeras in the context of an RNA world transition to an RNA/DNA world Angewandte Chemie-International Edition  2016 55:13204-13209  DOI:10.1002/anie.201607919  PMID:27650222
    • Butch, C. J., Wang, J., Gu, J., Vindas, R., Crowe, J., Pollet, P., Gelbaum, L., Leszczynski, J., Krishnamurthy, R., Liotta, C. L. pH-controlled reaction divergence of decarboxylation versus fragmentation in reactions of dihydroxyfumarate with glyoxylate and formaldehyde: parallels to biological pathways Journal of Physical Organic Chemistry  2016 29:352-360  DOI:10.1002/poc.3542
    • Cafferty, B. J., Fialho, D. M., Khanam, J., Krishnamurthy, R., Hud, N. V. Spontaneous formation and base pairing of plausible prebiotic nucleotides in water Nature Communications  2016 7  DOI:10.1038/ncomms11328  PMID:27108699  PMCID:PMC4848480
    • Cafferty, B. J., Musetti, C., Kim, K., Horowitz, E. D., Krishnamurthy, R., Hud, N. V. Small molecule-mediated duplex formation of nucleic acids with 'incompatible' backbones Chemical Communications  2016 52:5436-5439  DOI:10.1039/c6cc00779a  PMID:27009481
    • Forsythe, J. G., Yu, S. S., Mamajanov, I., Grover, M. A., Krishnamurthy, R., Fernandez, F. M., Hud, N. V. Ester-mediated amide bond formation driven by wet-dry cycles: a possible path to polypeptides on the prebiotic earth Angewandte Chemie-International Edition  2015 54:9871-9875  DOI:10.1002/anie.201503792  PMID:26201989  PMCID:PMC4678426
    • Krishnamurthy, R. On the Emergence of RNA Israel Journal of Chemistry  2015 55:837-850  DOI:10.1002/ijch.201400180
    • Diez-Martinez, A., Kim, E. K., Krishnamurthy, R. Hydrogen-bonding complexes of 5-azauracil and uracil derivatives in organic medium Journal of Organic Chemistry  2015 80:7066-7075  DOI:10.1021/acs.joc.5b00911  PMID:26098835
    • Kim, E. K., Krishnamurthy, R. Synthesis of orotidine by intramolecular nucleosidation Chemical Communications  2015 51:5618-5621  DOI:10.1039/c5cc00111k  PMID:25714895
    • Kim, K., Punna, V., Karri, P., Krishnamurthy, R. Synthesis of phosphoramidites of isoGNA, an isomer of glycerol nucleic acid Beilstein Journal of Organic Chemistry  2014 10:2131-2138  DOI:10.3762/bjoc.10.220  PMID:25246971  PMCID:PMC4168771
    • Parker, E. T., Zhou, M., Burton, A. S., Glavin, D. P., Dworkin, J. P., Krishnamurthy, R., Fernandez, F. M., Bada, J. L. A plausible simultaneous synthesis of amino acids and simple peptides on the primordial Earth Angewandte Chemie-International Edition  2014 53:8132-8136  DOI:10.1002/anie.201403683  PMID:24966137
    • Krishnamurthy, R. RNA as an emergent entity: an understanding gained through studying its nonfunctional alternatives Synlett  2014 25:1511-1517  DOI:10.1055/s-0033-1340183
    • Chen, M. C., Cafferty, B. J., Mamajanov, I., Gallego, I., Khanam, J., Krishnamurthy, R., Hud, N. V. Spontaneous prebiotic formation of a beta-ribofuranoside that self-assembles with a complementary heterocycle Journal of the American Chemical Society  2014 136:5640-5646  DOI:10.1021/ja410124v  PMID:24328232
    • Meher, G., Efthymiou, T., Stoop, M., Krishnamurthy, R. Microwave-assisted preparation of nucleoside-phosphoramidites Chemical Communications  2014 50:7463-7465  DOI:10.1039/c4cc03092c  PMID:24875746
    • Stoop, M., Meher, G., Karri, P., Krishnamurthy, R. Chemical etiology of nucleic acid structure: the pentulofuranosyl oligonucleotide systems: the (1'→3')-β-L-ribulo, (4'→3')-α-L-xylulo, and (1'→3')-α-L-xylulo nucleic acids Chemistry-a European Journal  2013 19:15336-15345  DOI:10.1002/chem.201302219  PMID:24150882
    • Butch, C., Cope, E. D., Pollet, P., Gelbaum, L., Krishnamurthy, R., Liotta, C. L. Production of tartrates by cyanide-mediated dimerization of glyoxylate: a potential abiotic pathway to the citric acid cycle Journal of the American Chemical Society  2013 135:13440-13445  DOI:10.1021/ja405103r  PMID:23914725  PMCID:PMC3777280
    • Hud, N. V., Cafferty, B. J., Krishnamurthy, R., Williams, L. D. The origin of RNA and "My Grandfather's Axe" Chemistry & Biology  2013 20:466-474  DOI:10.1016/j.chembiol.2013.03.012  PMID:23601635
    • Karri, P., Punna, V., Kim, K., Krishnamurthy, R. Base-pairing properties of a structural isomer of glycerol nucleic acid Angewandte Chemie-International Edition  2013 52:5840-5844  DOI:10.1002/anie.201300795  PMID:23606566
    • Krishnamurthy, R. Role of pK(a) of nucleobases in the origins of chemical evolution Accounts of Chemical Research  2012 45:2035-2044  DOI:10.1021/ar200262x  PMID:22533519  PMCID:PMC3525050
    • Kanakaraj, P., Puffer, B. A., Yao, X. T., Kankanala, S., Boyd, E., Shah, R. R., Wang, G. P., Patel, D., Krishnamurthy, R., Kaithamana, S., Smith, R. G., LaFleur, D. W., et al. Simultaneous targeting of TNF and Ang2 with a novel bispecific antibody enhances efficacy in an in vivo model of arthritis MAbs  2012 4:600-613  DOI:10.4161/mabs.21227  PMID:22864384  PMCID:PMC3499301
    • Sagi, V. N., Punna, V., Hu, F., Meher, G., Krishnamurthy, R. Exploratory experiments on the chemistry of the "glyoxylate scenario": Formation of ketosugars from dihydroxyfumarate Journal of the American Chemical Society  2012 134:3577-3589  DOI:10.1021/ja211383c  PMID:22280414  PMCID:PMC3284196
    • Hudson, J. S., Eberle, J. F., Vachhani, R. H., Rogers, L. C., Wade, J. H., Krishnamurthy, R., Springsteen, G. A unified mechanism for abiotic adenine and purine synthesis in formamide Angewandte Chemie-International Edition  2012 51:5134-5137  DOI:10.1002/anie.201108907  PMID:22488748
    • Hernandez-Rodriguez, M., Xie, J., Osornio, Y. M., Krishnamurthy, R. Mapping the landscape of potentially primordial informational oligomers: (3 '-> 2 ')-D-phosphoglyceric acid linked acyclic oligonucleotides tagged with 2,4-disubstituted 5-aminopyrimidines as recognition elements Chemistry-an Asian Journal  2011 6:1252-1262  DOI:10.1002/asia.201000828  PMID:21387563
    • Meher, G., Krishnamurthy, R. An expedient synthesis of L-ribulose and derivatives Carbohydrate Research  2011 346:703-707  DOI:10.1016/j.carres.2011.01.013  PMID:21396629
    • Sagi, V. N., Karri, P., Hu, F., Krishnamurthy, R. Diastereoselective self-condensation of dihydroxyfumaric acid in water: Potential route to sugars Angewandte Chemie-International Edition  2011 50:8127-8130  DOI:10.1002/anie.201102045  PMID:21748829
    • Krishnamurthy, R. A search for structural alternatives of RNA Journal of the Mexican Chemical Society  2009 53:23-33
    • Zhang, X. J., Krishnamurthy, R. Mapping the landscape of potentially primordial informational oligomers: Oligo-dipeptides tagged with orotic acid derivatives as recognition elements Angewandte Chemie-International Edition  2009 48:8124-8128  DOI:10.1002/anie.200904188  PMID:19768828
    • Ebert, M. O., Mang, C., Krishnamurthy, R., Eschenmoser, A., Jaun, B. The structure of a TNA-TNA complex in solution: NMR study of the octamer duplex derived from alpha-(L)-threofuranosyl-(3 '-2 ')-CGAATTCG Journal of the American Chemical Society  2008 130:15105-15115  DOI:10.1021/ja8041959  PMID:18928287
    • Mittapalli, G. K., Reddy, K. R., Xiong, H., Munoz, O., Han, B., De Riccardis, F., Krishnamurthy, R., Eschenmoser, A. Mapping the landscape of potentially primordial informational oligomers: Oligodipeptides and oligodipeptoids tagged with triazines as recognition elements Angewandte Chemie-International Edition  2007 46:2470-2477  DOI:10.1002/anie.200603207  PMID:17111452
    • Mittapalli, G. K., Osornio, Y. M., Guerrero, M. A., Reddy, K. R., Krishnamurthy, R., Eschenmoser, A. Mapping the landscape of potentially primordial informational oligomers: Oligodipeptides tagged with 2,4-disubstituted 5-aminopyrimidines as recognition elements Angewandte Chemie-International Edition  2007 46:2478-2484  DOI:10.1002/anie.200603209  PMID:17111453
    • Han, B., Rajwanshi, V., Nandy, J., Krishnamurthy, R., Eschenmoser, A. Mannich-type C-nucleosidations with 7-carba-purines and 4-aminopyrimidines Synlett  2005 744-750  DOI:10.1055/s-2005-864789
    • Wagner, T., Han, B., Koch, G., Krishnamurthy, R., Eschenmoser, A. Tautomerism in 5,8-diaza-7,9-dicarbaguanine ('alloguanine') Helvetica Chimica Acta  2005 88:1960-1968  DOI:10.1002/hlca.200590150
    • Han, B., Jaun, B., Krishnamurthy, R., Eschenmoser, A. Mannich-type C-nucleosidations in the 5,8-diaza-7,9-dicarba-purine family Organic Letters  2004 6:3691-3694  DOI:10.1021/ol048649m  PMID:15469325
    • Ferencic, M., Reddy, G., Wu, X. L., Guntha, S., Nandy, J., Krishnamurthy, R., Eschenmoser, A. Base-pairing systems related to TNA containing phosphoramidate linkages: Synthesis of building blocks and pairing properties Chemistry & Biodiversity  2004 1:939-979  DOI:10.1002/cbdv.200490083  PMID:17191894
    • Han, B., Wang, Z. J., Jaun, B., Krishnamurthy, R., Eschenmoser, A. C-nucleosidations with 2,6-diamino-5,8-diaza-7,9-dicarba-purine Organic Letters  2003 5:2071-2074  DOI:10.1021/ol030043v  PMID:12790531
    • Wang, Z. J., Huynh, H. K., Han, B., Krishnamurthy, R., Eschenmoser, A. 2,6-diamino-5,8-diaza-7,9-dicarba-purine Organic Letters  2003 5:2067-2070  DOI:10.1021/ol030044n  PMID:12790530
    • Pitsch, S., Wendeborn, S., Krishnamurthy, R., Holzner, A., Minton, M., Bolli, M., Miculca, C., Windhab, N., Micura, R., Stanek, M., Jaun, B., Eschenmoser, A. Pentopyranosyl oligonucleotide systems. 9th Communication. The β-D-ribopyranosyl-(4′ -> 2′)-oligonucleotide system (‘pyranosyl-RNA’): synthesis and resumé of base-pairing properties Helvetica Chimica Acta  2003 86:4270-4363  DOI:10.1002/hlca.200390349
    • Jungmann, O., Beier, M., Luther, A., Huynh, H. K., Ebert, M. O., Jaun, B., Krishnamurthy, R., Eschenmoser, A. Pentopyranosyl oligonucleotide systems. Communication No. 13. The α-L-arabinopyranosyl-(4′ -> 2′)-oligonucleotide system: synthesis and pairing properties Helvetica Chimica Acta  2003 86:1259-1308  DOI:10.1002/hlca.200390118
    • Pallan, P. S., Wilds, C. J., Wawrzak, Z., Krishnamurthy, R., Eschenmoser, A., Egli, M. Why does TNA cross-pair more strongly with RNA than with DNA? An answer from X-ray analysis Angewandte Chemie-International Edition  2003 42:5893-5895  DOI:10.1002/anie.200352553  PMID:14673929
    • Wilds, C. J., Wawrzak, Z., Krishnamurthy, R., Eschenmoser, A., Egli, M. Crystal structure of a B-form DNA duplex containing (L)-alpha-threofuranosyl (3 '-> 2 ') nucleosides: A four-carbon sugar is easily accommodated into the backbone of DNA Journal of the American Chemical Society  2002 124:13716-13721  DOI:10.1021/ja0207807  PMID:12431101
    • Wu, X. L., Delgado, G., Krishnamurthy, R., Eschenmoser, A. 2,6-diaminopurine in TNA: effect on duplex stabilities and on the efficiency of template-controlled ligations Organic Letters  2002 4:1283-1286  DOI:10.1021/ol020016p  PMID:11950343
    • Wu, X. L., Guntha, S., Ferencic, M., Krishnamurthy, R., Eschenmoser, A. Base-pairing systems related to TNA: alpha-threofuranosyl oligonucleotides containing phosphoramidate linkages Organic Letters  2002 4:1279-1282  DOI:10.1021/ol020015x  PMID:11950342
    • Ebert, M. O., Luther, A., Huynh, H. K., Krishnamurthy, R., Eschenmoser, A., Jaun, B. NMR solution structure of the duplex formed by self-pairing of α-L-arabinopyranosyl-(4′ -> 2′)-(CGAATTCG) Helvetica Chimica Acta  2002 85:4055-4073  DOI:10.1002/1522-2675(200211)85:11<4055::aid-hlca4055>3.0.co;2-j
    • Wagner, T., Huynh, H. K., Krishnamurthy, R., Eschenmoser, A. Pentopyranosyl oligonucleotide systems. Communication No. 12. The β-D-xylopyranosyl-(4′ -> 2′)-oligonucleotide system Helvetica Chimica Acta  2002 85:399-416  DOI:10.1002/1522-2675(200202)85:2<399::aid-hlca399>3.0.co;2-2
    • Schoning, K. U., Scholz, P., Wu, X. L., Guntha, S., Delgado, G., Krishnamurthy, R., Eschenmoser, A. The α-L-threofuranosyl-(3'-2')-oligonucleotide system ('TNA'): synthesis and pairing properties Helvetica Chimica Acta  2002 85:4111-4153  DOI:10.1002/hlca.200290000
    • Wippo, H., Reck, F., Kudick, R., Ramaseshan, M., Ceulemans, G., Bolli, M., Krishnamurthy, R., Eschenmoser, A. Pentopyranosyl oligonucleotide systems. Part 11: Systems with shortened backbones: (D)-beta-ribopyranosyl-(4 '-> 3 ')- and (l)-alpha-lyxopyranosyl-(4 '-> 3 ')-oligonucleotides Bioorganic & Medicinal Chemistry  2001 9:2411-2428  DOI:10.1016/s0968-0896(01)00220-6  PMID:11553483
    • Reck, F., Wippo, H., Kudick, R., Krishnamurthy, R., Eschenmoser, A. Pentopyranosyl oligonucleotide systems, Communication No. 10. The α-L-Lyxopyranosyl-(4' -> 2′)-oligonucleotide system Helvetica Chimica Acta  2001 84:1778-1804  DOI:10.1002/1522-2675(20010613)84:6<1778::aid-hlca1778>3.3.co;2-v
    • Schoning, K. U., Scholz, P., Guntha, S., Wu, X., Krishnamurthy, R., Eschenmoser, A. Chemical etiology of nucleic acid structure: The alpha-threofuranosyl-(3 '-> 2 ') oligonucleotide system Science  2000 290:1347-1351  DOI:10.1126/science.290.5495.1347  PMID:11082060
    • Eschenmoser, A., Krishnamurthy, R. Chemical etiology of nucleic acid structure Pure and Applied Chemistry  2000 72:343-345  DOI:10.1351/pac200072030343
    • Pitsch, S., Krishnamurthy, R., Arrhenius, G. Concentration of simple aldehydes by sulfite-containing double-layer hydroxide minerals: Implications for biopoesis Helvetica Chimica Acta  2000 83:2398-2411  DOI:10.1002/1522-2675(20000906)83:9<2398::aid-hlca2398>3.0.co;2-5  PMID:11543578
    • Krishnamurthy, R., Guntha, S., Eschenmoser, A. Regioselective alpha-phosphorylation of aldoses in aqueous solution Angewandte Chemie-International Edition  2000 39:2281-2285  DOI:10.1002/1521-3773(20000703)39:13<2281::aid-anie2281>3.0.co;2-2  PMID:10941064
    • Reck, F., Wippo, H., Kudick, R., Bolli, M., Ceulemans, G., Krishnamurthy, R., Eschenmoser, A. L-alpha-lyxopyranosyl (4 '-> 3 ') oligonucleotides: A base-pairing system containing a shortened backbone Organic Letters  1999 1:1531-1534  DOI:10.1021/ol990184q  PMID:10836020
    • Jungmann, O., Wippo, H., Stanek, M., Huynh, H. K., Krishnamurthy, R., Eschenmoser, A. Promiscuous Watson-Crick cross-pairing within the family of pentopyranosyl (4 '-> 2 ') oligonucleotides Organic Letters  1999 1:1527-1530  DOI:10.1021/ol990183y  PMID:10836019
    • Krishnamurthy, R., Arrhenius, G., Eschenmoser, A. Formation of glycolaldehyde phosphate from glycolaldehyde in aqueous solution Origins of Life and Evolution of the Biosphere  1999 29:333-354  DOI:10.1023/a:1006698208873  PMID:10472624
    • Krishnamurthy, R., Pitsch, S., Arrhenius, G. Mineral induced formation of pentose-2,4-bisphosphates Origins of Life and Evolution of the Biosphere  1999 29:139-152  DOI:10.1023/a:1006540518676  PMID:10227200
    • Beier, M., Reck, F., Wagner, T., Krishnamurthy, R., Eschenmoser, A. Chemical etiology of nucleic acid structure: Comparing pentopyranosyl-(2 '-> 4 ') oligonucleotides with RNA Science  1999 283:699-703  DOI:10.1126/science.283.5402.699  PMID:9924032
    • Krishnamurthy, R., Pitsch, S., Minton, M., Miculka, C., Windhab, N., Eschenmoser, A. Pyranosyl-RNA: Base pairing between homochiral oligonucleotide strands of opposite sense of chirality Angewandte Chemie-International Edition  1996 35:1537-1541  DOI:10.1002/anie.199615371
    • Pitsch, S., Krishnamurthy, R., Bolli, M., Wendeborn, S., Holzner, A., Minton, M., Lesueur, C., Schlonvogt, I., Jaun, B., Eschenmoser, A. Pyranosyl-RNA (‘p-RNA’): base-pairing selectivity and potential to replicate. Preliminary communication Helvetica Chimica Acta  1995 78:1621-1635  DOI:10.1002/hlca.19950780702
    • Hart, D. J., Krishnamurthy, R., Pook, L. M., Seely, F. L. Bis(tri-n-butylstannyl)benzopinacolate - preparation and use as a mediator of intermolecular free-radical reactions Tetrahedron Letters  1993 34:7819-7822  DOI:10.1016/s0040-4039(00)61484-3
    • Balakos, M. W., Chuang, S. S. C., Krishnamurthy, R., Srinivas, G., Johnston, P., Blackmond, D. G., Jackson, S. D., Joyner, R. W. The selective synthesis of c2+ oxygenates from syngas related reactions over ni-based and rh-based catalysts Studies in Surface Science and Catalysis  1993 75:1467-1478
    • Hart, D. J., Kim, A., Krishnamurthy, R., Merriman, G. H., Waltos, A. M. Synthesis of 6h-dibenzo b,d pyran-6-ones via dienone-phenol rearrangements of spiro 2,5-cyclohexadiene-1,1'(3'h)-isobenzofuran -3'-ones Tetrahedron  1992 48:8179-8188  DOI:10.1016/s0040-4020(01)80487-7
    • Hart, D. J., Krishnamurthy, R. Investigation of a model for 1,2-asymmetric induction in reactions of alpha-carbalkoxy radicals - a stereochemical comparison of reactions of alpha-carbalkoxy radicals and ester enolates Journal of Organic Chemistry  1992 57:4457-4470  DOI:10.1021/jo00042a029
    • Hart, D. J., Krishnamurthy, R. Stereoselective free-radical reactions at c(20) of steroid side-chains Synlett  1991 412-414
    • Hart, D. J., Huang, H. C., Krishnamurthy, R., Schwartz, T. Free-radical cyclizations - application to the total synthesis of dl-pleurotin and dl-dihydropleurotin acid Journal of the American Chemical Society  1989 111:7507-7519  DOI:10.1021/ja00201a035
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Research

research overview

  • Research in our group is focused on the use of synthetic organic chemistry and methodology to:

    1) experimentally address questions concerning the origins of life with respect to the advent of functional monomers and the emergence of informational polymers.

    2) fashion artificial informational polymers in order to expand the interface between synthetic nucleic acids and the natural biopolymers (proteins and RNA/DNA).

    3) make available novel molecular tools that may provide new avenues for probing biological systems and for research in synthetic biology.

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Teaching

advisees

  • undergraduate advising relationship

    • Krishnamurthy, Ramanarayanan (Faculty Member) advising Morris, Sydney 2014
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Background

education and training

  • Ph.D. in Chemistry, The Ohio State University 1992
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Contact

full name

  • Ramanarayanan Krishnamurthy

geographic location

  • Scripps California 
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Identity

ORCID iD

  • ORCID iD http://orcid.org/0000-0001-5238-610X

Scopus ID

  • 35619338500

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