recent publications
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academic article
- Vilums, M., Zweemer, A. J. M., Barmare, F., van der Gracht, A. M. F., Bleeker, D. C. T., Yu, Z., de Vries, H., Gross, R., Clemens, J., Krenitsky, P., Brussee, J., Stamos, D., et al. When structure-affinity relationships meet structure-kinetics relationships: 3-((Inden-1-yl)amino)-1-isopropyl-cyclopentane-1-carboxamides as CCR2 antagonists European Journal of Medicinal Chemistry 2015 93:121-134 DOI:10.1016/j.ejmech.2015.01.063 PMID:25666912
- Neubert, T., Numa, M., Ernst, J., Clemens, J., Krenitsky, P., Liu, M., Fleck, B., Woody, L., Zuccola, H., Stamos, D. Discovery of novel oxazepine and diazepine carboxamides as two new classes of heat shock protein 90 inhibitors Bioorganic & Medicinal Chemistry Letters 2015 25:1338-1342 DOI:10.1016/j.bmcl.2015.01.023 PMID:25677667
- Yang, W., Ye, S., Fanning, D., Coon, T., Schmidt, Y., Krenitsky, P., Stamos, D., Yu, J. Q. Orchestrated triple C-H activation reactions using two directing groups: rapid assembly of complex pyrazoles Angewandte Chemie-International Edition 2015 54:2501-2504 DOI:10.1002/anie.201410462 PMID:25641121 PMCID:PMC4426881
- Vilums, M., Zweemer, A. J. M., Yu, Z., de Vries, H., Hillger, J. M., Wapenaar, H., Bollen, I. A. E., Barmare, F., Gross, R., Clemens, J., Krenitsky, P., Brussee, J., et al. Structure-kinetic relationships--an overlooked parameter in hit-to-lead optimization: a case of cyclopentylamines as chemokine receptor 2 antagonists Journal of Medicinal Chemistry 2013 56:7706-7714 DOI:10.1021/jm4011737 PMID:24028535
- Clemens, J. J., Asgian, J. L., Busch, B. B., Coon, T., Ernst, J., Kaljevic, L., Krenitsky, P. J., Neubert, T. D., Schweiger, E. J., Termin, A., Stamos, D. Diastereoselective one-pot Knoevenagel condensation/Corey-Chaykovsky cyclopropanation Journal of Organic Chemistry 2013 78:780-785 DOI:10.1021/jo302443k PMID:23252964
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Krenitsky, P. J., Boger, D. L.
Synthesis of the (S,S,S)-diastereomer of the 15-membered biaryl ring system of RP 66453
Tetrahedron Letters
2003
44:4019-4022
DOI:10.1016/s0040-4039(03)00856-6
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Krenitsky, P. J., Boger, D. L.
Preparation of the 14-membered L,L-cycloisodityrosine subunit of RP 66453
Tetrahedron Letters
2002
43:407-410
DOI:10.1016/s0040-4039(01)02194-3
- Hodge, C. N., Aldrich, P. E., Wasserman, Z. R., Fernandez, C. H., Nemeth, G. A., Arvanitis, A., Cheeseman, R. S., Chorvat, R. J., Ciganek, E., Christos, T. E., Gilligan, P. J., Krenitsky, P., et al. Corticotropin-releasing hormone receptor antagonists: framework design and synthesis guided by ligand conformational studies Journal of Medicinal Chemistry 1999 42:819-832 DOI:10.1021/jm980223o PMID:10072680
- Arvanitis, A. G., Gilligan, P. J., Chorvat, R. J., Cheeseman, R. S., Christos, T. E., Bakthavatchalam, R., Beck, J. P., Cocuzza, A. J., Hobbs, F. W., Wilde, R. G., Arnold, C., Chidester, D., et al. Non-peptide corticotropin-releasing hormone antagonists: syntheses and structure-activity relationships of 2-anilinopyrimidines and -triazines Journal of Medicinal Chemistry 1999 42:805-818 DOI:10.1021/jm980222w PMID:10072679
- Chorvat, R. J., Bakthavatchalam, R., Beck, J. P., Gilligan, P. J., Wilde, R. G., Cocuzza, A. J., Hobbs, F. W., Cheeseman, R. S., Curry, M., Rescinito, J. P., Krenitsky, P., Chidester, D., et al. Synthesis, corticotropin-releasing factor receptor binding affinity, and pharmacokinetic properties of triazolo-, imidazo-, and pyrrolopyrimidines and -pyridines Journal of Medicinal Chemistry 1999 42:833-848 DOI:10.1021/jm980224g PMID:10072681
- Gilligan, P. J., Krenitsky, P. J. Divergent mechanisms for the dealkoxycarbonylation of a 2-(3-azetidinyl)malonate by chloride and cyanide Tetrahedron Letters 1994 35:3441-3444 DOI:10.1016/s0040-4039(00)73205-9