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Krenitsky, Paul

Graduate Student
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Positions

  • 2003 - Research Scientist, Vertex Pharmaceuticals

Websites

  • Doctoral Dissertation
  • Publications
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Publications

recent publications
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  • Publications without PubMed PMIDs

  • academic article

    • Vilums, M., Zweemer, A. J. M., Barmare, F., van der Gracht, A. M. F., Bleeker, D. C. T., Yu, Z., de Vries, H., Gross, R., Clemens, J., Krenitsky, P., Brussee, J., Stamos, D., et al. When structure-affinity relationships meet structure-kinetics relationships: 3-((Inden-1-yl)amino)-1-isopropyl-cyclopentane-1-carboxamides as CCR2 antagonists European Journal of Medicinal Chemistry  2015 93:121-134  DOI:10.1016/j.ejmech.2015.01.063  PMID:25666912
    • Neubert, T., Numa, M., Ernst, J., Clemens, J., Krenitsky, P., Liu, M., Fleck, B., Woody, L., Zuccola, H., Stamos, D. Discovery of novel oxazepine and diazepine carboxamides as two new classes of heat shock protein 90 inhibitors Bioorganic & Medicinal Chemistry Letters  2015 25:1338-1342  DOI:10.1016/j.bmcl.2015.01.023  PMID:25677667
    • Yang, W., Ye, S., Fanning, D., Coon, T., Schmidt, Y., Krenitsky, P., Stamos, D., Yu, J. Q. Orchestrated triple C-H activation reactions using two directing groups: rapid assembly of complex pyrazoles Angewandte Chemie-International Edition  2015 54:2501-2504  DOI:10.1002/anie.201410462  PMID:25641121  PMCID:PMC4426881
    • Vilums, M., Zweemer, A. J. M., Yu, Z., de Vries, H., Hillger, J. M., Wapenaar, H., Bollen, I. A. E., Barmare, F., Gross, R., Clemens, J., Krenitsky, P., Brussee, J., et al. Structure-kinetic relationships--an overlooked parameter in hit-to-lead optimization: a case of cyclopentylamines as chemokine receptor 2 antagonists Journal of Medicinal Chemistry  2013 56:7706-7714  DOI:10.1021/jm4011737  PMID:24028535
    • Clemens, J. J., Asgian, J. L., Busch, B. B., Coon, T., Ernst, J., Kaljevic, L., Krenitsky, P. J., Neubert, T. D., Schweiger, E. J., Termin, A., Stamos, D. Diastereoselective one-pot Knoevenagel condensation/Corey-Chaykovsky cyclopropanation Journal of Organic Chemistry  2013 78:780-785  DOI:10.1021/jo302443k  PMID:23252964
    • degree-related publication Krenitsky, P. J., Boger, D. L. Synthesis of the (S,S,S)-diastereomer of the 15-membered biaryl ring system of RP 66453 Tetrahedron Letters  2003 44:4019-4022  DOI:10.1016/s0040-4039(03)00856-6
    • degree-related publication Krenitsky, P. J., Boger, D. L. Preparation of the 14-membered L,L-cycloisodityrosine subunit of RP 66453 Tetrahedron Letters  2002 43:407-410  DOI:10.1016/s0040-4039(01)02194-3
    • Hodge, C. N., Aldrich, P. E., Wasserman, Z. R., Fernandez, C. H., Nemeth, G. A., Arvanitis, A., Cheeseman, R. S., Chorvat, R. J., Ciganek, E., Christos, T. E., Gilligan, P. J., Krenitsky, P., et al. Corticotropin-releasing hormone receptor antagonists: framework design and synthesis guided by ligand conformational studies Journal of Medicinal Chemistry  1999 42:819-832  DOI:10.1021/jm980223o  PMID:10072680
    • Arvanitis, A. G., Gilligan, P. J., Chorvat, R. J., Cheeseman, R. S., Christos, T. E., Bakthavatchalam, R., Beck, J. P., Cocuzza, A. J., Hobbs, F. W., Wilde, R. G., Arnold, C., Chidester, D., et al. Non-peptide corticotropin-releasing hormone antagonists: syntheses and structure-activity relationships of 2-anilinopyrimidines and -triazines Journal of Medicinal Chemistry  1999 42:805-818  DOI:10.1021/jm980222w  PMID:10072679
    • Chorvat, R. J., Bakthavatchalam, R., Beck, J. P., Gilligan, P. J., Wilde, R. G., Cocuzza, A. J., Hobbs, F. W., Cheeseman, R. S., Curry, M., Rescinito, J. P., Krenitsky, P., Chidester, D., et al. Synthesis, corticotropin-releasing factor receptor binding affinity, and pharmacokinetic properties of triazolo-, imidazo-, and pyrrolopyrimidines and -pyridines Journal of Medicinal Chemistry  1999 42:833-848  DOI:10.1021/jm980224g  PMID:10072681
    • Gilligan, P. J., Krenitsky, P. J. Divergent mechanisms for the dealkoxycarbonylation of a 2-(3-azetidinyl)malonate by chloride and cyanide Tetrahedron Letters  1994 35:3441-3444  DOI:10.1016/s0040-4039(00)73205-9
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Background

education and training

  • Ph.D. in Chemistry, Scripps Research 1998 - 2003
  • B.S. in Chemistry, Drexel University 1998

advisee of

  • graduate advising relationship

    • Boger, Dale, Ph.D.  candidacy, 1999 - 2003
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Contact

full name

  • Paul John Krenitsky

geographic location

  • Scripps California 

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