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Koob, George
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Koob, George

Faculty Member
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Positions

  • 2017 - Professor, Neuroscience , Scripps Research
  • 2014 - Director, National Institute on Alcohol Abuse and Alcoholism , National Institutes of Health
  • 2006 - 2014 Committee Chair, Committee on the Neurobiology of Addictive Disorders (CNAD) , Scripps Research
  • 2006 - 2014 Professor, Committee on the Neurobiology of Addictive Disorders (CNAD) , Scripps Research
  • 2003 - 2014 Co-Director, Pearson Center for Alcohol and Addiction Research , Scripps Research
  • 1990 - 2006 Professor, Molecular and Integrative Neurosciences (MIND) , Scripps Research
  • 1983 - 1989 Associate Member (with tenure), Division of Preclinical Neuroscience and Endocrinology, Research Institute of Scripps Clinic
  • 1977 - 1983 Staff Scientist, Arthur Vining Davis Center for Behavioral Neurobiology, Salk Institute for Biological Studies
  • 1975 - 1977 Postdoctoral Fellow with Dr. Susan D. Iversen, Department of Experimental Psychology, Medical Research Council, Neurochemical Pharmacology Unit, University of Cambridge
  • 1972 - 1975 Staff Scientist, Department of Neurophysiology, Walter Reed Army Institute of Research
Dr. George Koob is currently on a leave of absence from The Scripps Research Institute to serve as Director of the National Institute on Alcohol Abuse and Alcoholism at the U.S. National Institutes of Health.

Research Areas research areas

  • Addiction (UMLS)
  • Mental Illness (UMLS)

Contact

  • gkoob@scripps.edu

Websites

  • George Koob, Ph.D.
  • Committee on Neurobiology of Addictive Disorders
  • Pearson Center for Alcoholism & Addiction Research
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Publications

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    • Ray, L. A., Grodin, E. N., Leggio, L., Bechtholt, A. J., Becker, H., Ewing, S. F. W., Jentsch, J. D., King, A. C., Mason, B. J., O'Malley, S., MacKillop, J., Heilig, M., et al. The future of translational research on alcohol use disorder Addiction Biology  2020  DOI:10.1111/adb.12903  PMID:32286721
    • Xu, J., Ma, H. Y., Liu, X., Rosenthal, S., Baglieri, J., McCubbin, R., Sun, M., Koyama, Y., Geoffroy, C. G., Saijo, K., Shang, L., Nishio, T., et al. Blockade of IL-17 signaling reverses alcohol-induced liver injury and excessive alcohol drinking in mice Jci Insight  2020 5  DOI:10.1172/jci.insight.131277  PMID:32051339  PMCID:PMC7098802
    • Tunstall, B. J., Lorrai, I., McConnell, S. A., Gazo, K. L., Zeller, L. J., de Guglielmo, G., Hoang, I., Haass-Koffler, C. L., Repunte-Canonigo, V., Koob, G. F., Vendruscolo, L. F., Sanna, P. P. Probenecid reduces alcohol drinking in rodents. is pannexin1 a novel therapeutic target for alcohol use disorder? Alcohol and Alcoholism  2019 54:497-502  DOI:10.1093/alcalc/agz054  PMID:31535696  PMCID:PMC6751410
    • Zorrilla, E. P., Koob, G. F. Impulsivity derived from the dark side: neurocircuits that contribute to negative urgency Frontiers in Behavioral Neuroscience  2019 13  DOI:10.3389/fnbeh.2019.00136  PMID:31293401  PMCID:PMC6603097
    • Tunstall, B. J., Kirson, D., Zallar, L. J., McConnell, S. A., Vendruscolo, J. C. M., Ho, C. P., Oleata, C. S., Khom, S., Manning, M., Lee, M. R., Leggio, L., Koob, G. F., et al. Oxytocin blocks enhanced motivation for alcohol in alcohol dependence and blocks alcohol effects on GABAergic transmission in the central amygdala PLoS Biology  2019 17  DOI:10.1371/journal.pbio.2006421  PMID:30990816  PMCID:PMC6467366
    • de Guglielmo, G., Kallupi, M., Pomrenze, M. B., Crawford, E., Simpson, S., Schweitzer, P., Koob, G. F., Messing, R. O., George, O. Inactivation of a CRF-dependent amygdalofugal pathway reverses addiction-like behaviors in alcohol-dependent rats Nature Communications  2019 10  DOI:10.1038/s41467-019-09183-0  PMID:30886240  PMCID:PMC6423296
    • Pelloux, Y., Degoulet, M., Tiran-Cappello, A., Cohen, C., Lardeux, S., George, O., Koob, G. F., Ahmed, S. H., Baunez, C. Subthalamic nucleus high frequency stimulation prevents and reverses escalated cocaine use Molecular Psychiatry  2018 23:2266-2276  DOI:10.1038/s41380-018-0080-y  PMID:29880881
    • Schmeichel, B. E., Matzeu, A., Koebel, P., Vendruscolo, L. F., Sidhu, H., Shahryari, R., Kieffer, B. L., Koob, G. F., Martin-Fardon, R., Contet, C. Knockdown of hypocretin attenuates extended access of cocaine self-administration in rats Neuropsychopharmacology  2018 43:2373-2382  DOI:10.1038/s41386-018-0054-4  PMID:29703996  PMCID:PMC6180106
    • Frantz, K., Roberto, M., Mason, B., Koob, G. F., Volkow, N., de Fonseca, F. R. Larry Parsons: Researcher, mentor, and friend Addiction Biology  2018 23:1204-1206  DOI:10.1111/adb.12686  PMID:30485629
    • Verheij, M. M. M., Contet, C., Karel, P., Latour, J., van der Doelen, R. H. A., Geenen, B., van Hulten, J. A., Meyer, F., Kozicz, T., George, O., Koob, G. F., Homberg, J. R. Median and dorsal raphe serotonergic neurons control moderate versus compulsive cocaine intake Biological Psychiatry  2018 83:1024-1035  DOI:10.1016/j.biopsych.2017.10.031  PMID:29357981  PMCID:PMC5960600
    • Aoun, E. G., Jimenez, V. A., Vendruscolo, L. F., Walter, N. A. R., Barbier, E., Ferrulli, A., Haass-Koffler, C. L., Darakjian, P., Lee, M. R., Addolorato, G., Heilig, M., Hitzemann, R., et al. A relationship between the aldosterone-mineralocorticoid receptor pathway and alcohol drinking: preliminary translational findings across rats, monkeys and humans Molecular Psychiatry  2018 23:1466-1473  DOI:10.1038/mp.2017.97  PMID:28461696  PMCID:PMC5668213
    • Kenny, P. J., Hoyer, D., Koob, G. F. Animal models of addiction and neuropsychiatric disorders and their role in drug discovery: honoring the legacy of Athina Markou Biological Psychiatry  2018 83:940-946  DOI:10.1016/j.biopsych.2018.02.009  PMID:29602521
    • Vendruscolo, J. C. M., Tunstall, B. J., Carmack, S. A., Schmeichel, B. E., Lowery-Gionta, E. G., Cole, M., George, O., Vandewater, S. A., Taffe, M. A., Koob, G. F., Vendruscolo, L. F. Compulsive-like sufentanil vapor self-administration in rats Neuropsychopharmacology  2018 43:801-809  DOI:10.1038/npp.2017.172  PMID:28812595  PMCID:PMC5809787
    • Logrip, M. L., Walker, J. R., Ayanwuyi, L. O., Sabino, V., Ciccocioppo, R., Koob, G. F., Zorrilla, E. P. Evaluation of alcohol preference and drinking in msP rats bearing a Crhr1 promoter polymorphism Frontiers in Psychiatry  2018 9  DOI:10.3389/fpsyt.2018.00028
    • Tian, Y. H., Ma, S. X., Lee, K. W., Wee, S., Koob, G. F., Lee, S. Y., Jang, C. G. Blockade of TRPV1 inhibits methamphetamine-induced rewarding effects Scientific Reports  2018 8  DOI:10.1038/s41598-018-19207-2  PMID:29343767  PMCID:PMC5772440
    • Francesconi, W., Szucs, A., Berton, F., Koob, G. F., Vendruscolo, L. F., Sanna, P. P. Opiate dependence induces cell type-specific plasticity of intrinsic membrane properties in the rat juxtacapsular bed nucleus of stria terminalis (jcBNST) Psychopharmacology  2017 234:3485-3498  DOI:10.1007/s00213-017-4732-4  PMID:28986608
    • George, O., Koob, G. F. Individual differences in the neuropsychopathology of addiction Dialogues in Clinical Neuroscience  2017 19:217-229
    • Wade, C. L., Kallupi, M., Hernandez, D. O., Breysse, E., de Guglielmo, G., Crawford, E., Koob, G. F., Schweitzer, P., Baunez, C., George, O. High-frequency stimulation of the subthalamic nucleus blocks compulsive-like re-escalation of heroin taking in rats Neuropsychopharmacology  2017 42:1850-1859  DOI:10.1038/npp.2016.270  PMID:27917870
    • Schmeichel, B. E., Herman, M. A., Roberto, M., Koob, G. F. Hypocretin neurotransmission within the central amygdala mediates escalated cocaine self-administration and stress-induced reinstatement in rats Biological Psychiatry  2017 81:606-615  DOI:10.1016/j.biopsych.2016.06.010  PMID:27567312  PMCID:PMC5161745
    • Koob, G. F. The dark side of addiction: The Horsley Gantt to Joseph Brady connection Journal of Nervous and Mental Disease  2017 205:270-272  DOI:10.1097/nmd.0000000000000551  PMID:27356121
    • Harris, R. A., Bajo, M., Bell, R. L., Blednov, Y. A., Varodayan, F. P., Truitt, J. M., de Guglielmo, G., Lasek, A. W., Logrip, M. L., Vendruscolo, L. F. Genetic and Pharmacologic Manipulation of TLR4 Has Minimal Impact on Ethanol Consumption in Rodents Journal of Neuroscience  2017 37:1139-1155  DOI:10.1523/jneurosci.2002-16.2016  PMID:27986929  PMCID:PMC5296793
    • Galinato, M. H., Lockner, J. W., Fannon-Pavlich, M. J., Sobieraj, J. C., Staples, M. C., Somkuwar, S. S., Ghofranian, A., Chaing, S., Navarro, A. I., Joea, A., Luikart, B. W., Janda, K. D., et al. A synthetic small-molecule Isoxazole-9 protects against methamphetamine relapse Molecular Psychiatry  2017 23:629-638  DOI:10.1038/mp.2017.46  PMID:28348387  PMCID:PMC5617764
    • de Guglielmo, G., Crawford, E., Kim, S., Vendruscolo, L. F., Hope, B. T., Brennan, M., Cole, M., Koob, G. F., George, O. Recruitment of a neuronal ensemble in the central nucleus of the amygdala is required for alcohol dependence Journal of Neuroscience  2016 36:9446-9453  DOI:10.1523/jneurosci.1395-16.2016  PMID:27605618  PMCID:PMC5013191
    • Verheij, M. M. M., Vendruscolo, L. F., Caffino, L., Giannotti, G., Cazorla, M., Fumagalli, F., Riva, M. A., Homberg, J. R., Koob, G. F., Contet, C. Systemic Delivery of a Brain-Penetrant TrkB Antagonist Reduces Cocaine Self-Administration and Normalizes TrkB Signaling in the Nucleus Accumbens and Prefrontal Cortex Journal of Neuroscience  2016 36:8149-8159  DOI:10.1523/jneurosci.2711-14.2016  PMID:27488635  PMCID:PMC4971362
    • Koob, G. F., Volkow, N. D. Neurobiology of addiction: a neurocircuitry analysis Lancet Psychiatry  2016 3:760-773  PMID:27475769
    • You, I. J., Wright, S. R., Garcia-Garcia, A. L., Tapper, A. R., Gardner, P. D., Koob, G. F., Leonardo, E. D., Bohn, L. M., Wee, S. 5-HT1A autoreceptors in the dorsal raphe nucleus convey vulnerability to compulsive cocaine seeking Neuropsychopharmacology  2016 41:1210-1222  DOI:10.1038/npp.2015.268  PMID:26324408  PMCID:PMC4793105
    • Collins, F. S., Anderson, J. M., Austin, C. P., Battey, J. F., Birnbaum, L. S., Briggs, J. P., Clayton, J. A., Cuthbert, B., Eisinger, R. W., Fauci, A. S., Gallin, J. I., Gibbons, G. H., et al. Basic science: Bedrock of progress Science  2016 351:1405-1405  PMID:27013720  PMCID:PMC5101936
    • Sanna, P. P., Kawamura, T., Chen, J., Koob, G. F., Roberts, A. J., Vendruscolo, L. F., Repunte-Canonigo, V. 11β-hydroxysteroid dehydrogenase inhibition as a new potential therapeutic target for alcohol abuse Translational Psychiatry  2016 6  DOI:10.1038/tp.2016.13  PMID:26978742  PMCID:PMC4872439
    • Koob, G. F., Mason, B. J. Existing and future drugs for the treatment of the dark side of addiction Annual Review of Pharmacology and Toxicology  2016 56:299-322  DOI:10.1146/annurev-pharmtox-010715-103143  PMID:26514207
    • Saba, L. M., Flink, S. C., Vanderlinden, L. A., Israel, Y., Tampier, L., Colombo, G., Kiianmaa, K., Bell, R. L., Printz, M. P., Flodman, P., Koob, G., Richardson, H. N., et al. The sequenced rat brain transcriptome - its use in identifying networks predisposing alcohol consumption FEBS Journal  2015 282:3556-3578  DOI:10.1111/febs.13358  PMID:26183165  PMCID:PMC4573833
    • Volkow, N. D., Koob, G. Brain disease model of addiction: why is it so controversial? Lancet Psychiatry  2015 2:677-679  PMID:26249284  PMCID:PMC4556943
    • Cui, C., Noronha, A., Warren, K. R., Koob, G. F., Sinha, R., Thakkar, M., Matochik, J., Crews, F. T., Chandler, L. J., Pfefferbaum, A., Becker, H. C., Lovinger, D., et al. Brain pathways to recovery from alcohol dependence Alcohol  2015 49:435-452  DOI:10.1016/j.alcohol.2015.04.006  PMID:26074423  PMCID:PMC4468789
    • Vendruscolo, L. F., Estey, D., Goodell, V., Macshane, L. G., Logrip, M. L., Schlosburg, J. E., McGinn, M. A., Zamora-Martinez, E. R., Belanoff, J. K., Hunt, H. J., Sanna, P. P., George, O., et al. Glucocorticoid receptor antagonism decreases alcohol seeking in alcohol-dependent individuals Journal of Clinical Investigation  2015 125:3193-3197  DOI:10.1172/jci79828  PMID:26121746
    • Schmeichel, B. E., Barbier, E., Misra, K. K., Contet, C., Schlosburg, J. E., Grigoriadis, D., Williams, J. P., Karlsson, C., Pitcairn, C., Heilig, M., Koob, G. F., Vendruscolo, L. F. Hypocretin receptor 2 antagonism dose-dependently reduces escalated heroin self-administration in rats Neuropsychopharmacology  2015 40:1123-1129  DOI:10.1038/npp.2014.293  PMID:25367502  PMCID:PMC4367454
    • Park, P. E., Schlosburg, J. E., Vendruscolo, L. F., Schulteis, G., Edwards, S., Koob, G. F. Chronic CRF1 receptor blockade reduces heroin intake escalation and dependence-induced hyperalgesia Addiction Biology  2015 20:275-284  DOI:10.1111/adb.12120  PMID:24330252  PMCID:PMC4057367
    • Leao, R. M., Cruz, F. C., Vendruscolo, L. F., de Guglielmo, G., Logrip, M. L., Planeta, C. S., Hope, B. T., Koob, G. F., George, O. Chronic nicotine activates stress/reward-related brain regions and facilitates the transition to compulsive alcohol drinking Journal of Neuroscience  2015 35:6241-6253  DOI:10.1523/jneurosci.3302-14.2015  PMID:25878294
    • Wade, C. L., Vendruscolo, L. F., Schlosburg, J. E., Hernandez, D. O., Koob, G. F. Compulsive-like responding for opioid analgesics in rats with extended access Neuropsychopharmacology  2015 40:421-428  DOI:10.1038/npp.2014.188  PMID:25060491  PMCID:PMC4443956
    • Cohen, A., Soleiman, M. T., Talia, R., Koob, G. F., George, O., Mandyam, C. D. Extended access nicotine self-administration with periodic deprivation increases immature neurons in the hippocampus Psychopharmacology  2015 232:453-463  DOI:10.1007/s00213-014-3685-0  PMID:25059540  PMCID:PMC4297709
    • Cohen, A., Treweek, J., Edwards, S., Leao, R. M., Schulteis, G., Koob, G. F., George, O. Extended access to nicotine leads to a CRF1 receptor dependent increase in anxiety-like behavior and hyperalgesia in rats Addiction Biology  2015 20:56-68  DOI:10.1111/adb.12077  PMID:23869743  PMCID:PMC3859819
    • Whitfield Jr., T. W., Schlosburg, J. E., Wee, S., Gould, A., George, O., Grant, Y., Zamora-Martinez, E. R., Edwards, S., Crawford, E., Vendruscolo, L. F., Koob, G. F. κ Opioid receptors in the nucleus accumbens shell mediate escalation of methamphetamine intake Journal of Neuroscience  2015 35:4296-4305  DOI:10.1523/jneurosci.1978-13.2015  PMID:25762676  PMCID:PMC4355200
    • Grieder, T. E., Herman, M. A., Contet, C., Tan, L. A., Vargas-Perez, H., Cohen, A., Chwalek, M., Maal-Bared, G., Freiling, J., Schlosburg, J. E., Clarke, L., Crawford, E., et al. VTA CRF neurons mediate the aversive effects of nicotine withdrawal and promote intake escalation Nature Neuroscience  2014 17:1751-1758  DOI:10.1038/nn.3872  PMID:25402857  PMCID:PMC4241147
    • George, O., Koob, G. F., Vendruscolo, L. F. Negative reinforcement via motivational withdrawal is the driving force behind the transition to addiction Psychopharmacology  2014 231:3911-3917  DOI:10.1007/s00213-014-3623-1  PMID:24923982
    • Buck, C. L., Malavar, J. C., George, O., Koob, G. F., Vendruscolo, L. F. Anticipatory 50 kHz ultrasonic vocalizations are associated with escalated alcohol intake in dependent rats Behavioural Brain Research  2014 271:171-176  DOI:10.1016/j.bbr.2014.06.003  PMID:24914463  PMCID:PMC4216724
    • Repunte-Canonigo, V., Lefebvre, C., George, O., Kawamura, T., Morales, M., Koob, G. F., Califano, A., Masliah, E., Sanna, P. P. Gene expression changes consistent with neuroAIDS and impaired working memory in HIV-1 transgenic rats Molecular Neurodegeneration  2014 9:26  DOI:10.1186/1750-1326-9-26  PMID:24980976  PMCID:PMC4107468
    • Deschaux, O., Vendruscolo, L. F., Schlosburg, J. E., Diaz-Aguilar, L., Yuan, C. J., Sobieraj, J. C., George, O., Koob, G. F., Mandyam, C. D. Hippocampal neurogenesis protects against cocaine-primed relapse Addiction Biology  2014 19:562-574  DOI:10.1111/adb.12019  PMID:23278919  PMCID:PMC3620729
    • Vanderlinden, L. A., Saba, L. M., Printz, M. P., Flodman, P., Koob, G., Richardson, H. N., Hoffman, P. L., Tabakoff, B. Is the alcohol deprivation effect genetically mediated? Studies with HXB/BXH recombinant inbred rat strains Alcoholism-Clinical and Experimental Research  2014 38:2148-2157  DOI:10.1111/acer.12471  PMID:24961585  PMCID:PMC4142977
    • Logrip, M. L., Vendruscolo, L. F., Schlosburg, J. E., Koob, G. F., Zorrilla, E. P. Phosphodiesterase 10A regulates alcohol and saccharin self-administration in rats Neuropsychopharmacology  2014 39:1722-1731  DOI:10.1038/npp.2014.20  PMID:24549104  PMCID:PMC4023146
    • Cohen, A., Whitfield, T. W., Kreifeldt, M., Koebel, P., Kieffer, B. L., Contet, C., George, O., Koob, G. F. Virus-mediated shRNA knockdown of prodynorphin in the rat nucleus accumbens attenuates depression-like behavior and cocaine locomotor sensitization PLoS One  2014 9:e97216  DOI:10.1371/journal.pone.0097216  PMID:24816773  PMCID:PMC4016270
    • Mazei-Robison, M. S., Appasani, R., Edwards, S., Wee, S., Taylor, S. R., Picciotto, M. R., Koob, G. F., Nestler, E. J. Self-administration of ethanol, cocaine, or nicotine does not decrease the soma size of ventral tegmental area dopamine neurons PLoS One  2014 9:e95962  DOI:10.1371/journal.pone.0095962  PMID:24755634  PMCID:PMC3995955
    • Zorrilla, E. P., Logrip, M. L., Koob, G. F. Corticotropin releasing factor: a key role in the neurobiology of addiction Frontiers in Neuroendocrinology  2014 35:234-244  DOI:10.1016/j.yfrne.2014.01.001  PMID:24456850  PMCID:PMC4213066
    • Buck, C. L., Vendruscolo, L. F., Koob, G. F., George, O. Dopamine D1 and mu-opioid receptor antagonism blocks anticipatory 50 kHz ultrasonic vocalizations induced by palatable food cues in Wistar rats Psychopharmacology  2014 231:929-937  DOI:10.1007/s00213-013-3307-2  PMID:24221826  PMCID:PMC3945412
    • Hicks, M. J., Kaminsky, S. M., De, B. P., Rosenberg, J. B., Evans, S. M., Foltin, R. W., Andrenyak, D. M., Moody, D. E., Koob, G. F., Janda, K. D., Arbona, R. J. R., Lepherd, M. L., et al. Fate of systemically administered cocaine in nonhuman primates treated with the dAd5GNE anticocaine vaccine Human Gene Therapy Clinical Development  2014 25:40-49  DOI:10.1089/humc.2013.231  PMID:24649839  PMCID:PMC4047994
    • Gilpin, N. W., Roberto, M., Koob, G. F., Schweitzer, P. Kappa opioid receptor activation decreases inhibitory transmission and antagonizes alcohol effects in rat central amygdala Neuropharmacology  2014 77:294-302  DOI:10.1016/j.neuropharm.2013.10.005  PMID:24157490  PMCID:PMC3873141
    • Koob, G. F., Buck, C. L., Cohen, A., Edwards, S., Park, P. E., Schlosburg, J. E., Schmeichel, B., Vendruscolo, L. F., Wade, C. L., Whitfield, T. W., George, O. Addiction as a stress surfeit disorder Neuropharmacology  2014 76:370-382  DOI:10.1016/j.neuropharm2013.05.024  PMID:23747571  PMCID:PMC3830720
    • Kallupi, M., Vendruscolo, L. F., Carmichael, C. Y., George, O., Koob, G. F., Gilpin, N. W. Neuropeptide Y Y2R blockade in the central amygdala reduces anxiety-like behavior but not alcohol drinking in alcohol-dependent rats Addiction Biology  2014 19:755-757  DOI:10.1111/adb.12059  PMID:23639035  PMCID:PMC3872251
    • Wise, R. A., Koob, G. F. The development and maintenance of drug addiction Neuropsychopharmacology  2014 39:254-262  DOI:10.1038/npp.2013.261  PMID:24121188  PMCID:PMC3870778
    • Schlosburg, J. E., Whitfield, T. W., Park, P. E., Crawford, E. F., George, O., Vendruscolo, L. F., Koob, G. F. Long-term antagonism of κ opioid receptors prevents escalation of and increased motivation for heroin intake Journal of Neuroscience  2013 33:19384-19392  DOI:10.1523/jneurosci.1979-13.2013  PMID:24305833  PMCID:PMC3850049
    • Zorrilla, E. P., Koob, G. F. Amygdalostriatal projections in the neurocircuitry for motivation: a neuroanatomical thread through the career of Ann Kelley Neuroscience and Biobehavioral Reviews  2013 37:1932-1945  DOI:10.1016/j.neubiorev.2012.11.019  PMID:23220696  PMCID:PMC3838492
    • Apkarian, A. V., Neugebauer, V., Koob, G., Edwards, S., Levine, J. D., Ferrari, L., Egli, M., Regunathan, S. Neural mechanisms of pain and alcohol dependence Pharmacology, Biochemistry and Behavior  2013 112:34-41  DOI:10.1016/j.pbb.2013.09.008  PMID:24095683  PMCID:PMC4887744
    • Cai, X., Whitfield, T., Moreno, A. Y., Grant, Y., Hixon, M. S., Koob, G. F., Janda, K. D. Probing the effects of hapten stability on cocaine vaccine immunogenicity Molecular Pharmaceutics  2013 10:4176-4184  DOI:10.1021/mp400214w  PMID:23927436  PMCID:PMC3946501
    • Maoz, A., Hicks, M. J., Vallabhjosula, S., Synan, M., Kothari, P. J., Dyke, J. P., Ballon, D. J., Kaminsky, S. M., De, B. P., Rosenberg, J. B., Martinez, D., Koob, G. F., et al. Adenovirus capsid-based anti-cocaine vaccine prevents cocaine from binding to the nonhuman primate CNS dopamine transporter Neuropsychopharmacology  2013 38:2170-2178  DOI:10.1038/npp.2013.114  PMID:23660705  PMCID:PMC3773666
    • Kallupi, M., Wee, S., Edwards, S., Whitfield, T. W., Oleata, C. S., Luu, G., Schmeichel, B. E., Koob, G. F., Roberto, M. Kappa opioid receptor-mediated dysregulation of gamma-aminobutyric acidergic transmission in the central amygdala in cocaine addiction Biological Psychiatry  2013 74:520-528  DOI:10.1016/j.biopsych.2013.04.028  PMID:23751206  PMCID:PMC3773286
    • Park, P. E., Vendruscolo, L. F., Schlosburg, J. E., Edwards, S., Schulteis, G., Koob, G. F. Corticotropin-releasing factor (CRF) and alpha 2 adrenergic receptors mediate heroin withdrawal-potentiated startle in rats International Journal of Neuropsychopharmacology  2013 16:1867-1875  DOI:10.1017/s1461145713000308  PMID:23590881  PMCID:PMC3880138
    • Edwards, S., Koob, G. F. Escalation of drug self-administration as a hallmark of persistent addiction liability Behavioural Pharmacology  2013 24:356-362  DOI:10.1097/FBP.0b013e3283644d15  PMID:23839030  PMCID:PMC3866817
    • Zorrilla, E. P., Roberts, A. J., Rivier, J. E., Koob, G. F. Anxiolytic-Like Effects of Antisauvagine-30 in Mice Are Not Mediated by CRF2 Receptors PLoS One  2013 8:e63942  DOI:10.1371/journal.pone.0063942  PMID:24015170  PMCID:PMC3756045
    • Koob, G. F. Negative reinforcement in drug addiction: the darkness within Current Opinion in Neurobiology  2013 23:559-563  DOI:10.1016/j.conb.2013.03.011  PMID:23628232
    • Edwards, S., Baynes, B. B., Carmichael, C. Y., Zamora-Martinez, E. R., Barrus, M., Koob, G. F., Gilpin, N. W. Traumatic stress reactivity promotes excessive alcohol drinking and alters the balance of prefrontal cortex-amygdala activity Translational Psychiatry  2013 3:e296  DOI:10.1038/tp.2013.70  PMID:23982628  PMCID:PMC3756295
    • Chen, J. H., Repunte-Canonigo, V., Kawamura, T., Lefebvre, C., Shin, W., Howell, L. L., Hemby, S. E., Harvey, B. K., Califano, A., Morales, M., Koob, G. F., Sanna, P. P. Hypothalamic proteoglycan syndecan-3 is a novel cocaine addiction resilience factor Nature Communications  2013 4:1955  DOI:10.1038/ncomms2955  PMID:23736082  PMCID:PMC3709481
    • Schlosburg, J. E., Vendruscolo, L. F., Bremer, P. T., Lockner, J. W., Wade, C. L., Nunes, A. A., Stowe, G. N., Edwards, S., Janda, K. D., Koob, G. F. Dynamic vaccine blocks relapse to compulsive intake of heroin Proceedings of the National Academy of Sciences of the United States of America  2013 110:9036-9041  DOI:10.1073/pnas.1219159110  PMID:23650354  PMCID:PMC3670323
    • Cai, X., Whitfield, T., Hixon, M. S., Grant, Y., Koob, G. F., Janda, K. D. Probing active cocaine vaccination performance through catalytic and noncatalytic hapten design Journal of Medicinal Chemistry  2013 56:3701-3709  DOI:10.1021/jm400228w  PMID:23627877  PMCID:PMC3691275
    • Barbier, E., Vendruscolo, L. F., Schlosburg, J. E., Edwards, S., Juergens, N., Park, P. E., Misra, K. K., Cheng, K. J., Rice, K. C., Schank, J., Schulteis, G., Koob, G. F., et al. The NK1 receptor antagonist l822429 reduces heroin reinforcement Neuropsychopharmacology  2013 38:976-984  DOI:10.1038/npp.2012.261  PMID:23303056  PMCID:PMC3629386
    • Herman, M. A., Kallupi, M., Luu, G., Oleata, C. S., Heilig, M., Koob, G. F., Ciccocioppo, R., Roberto, M. Enhanced gabaergic transmission in the central nucleus of the amygdala of genetically selected marchigian sardinian rats: Alcohol and crf effects Neuropharmacology  2013 67:337-348  DOI:10.1016/j.neuropharm.2012.11.026  PMID:23220399  PMCID:PMC3562384
    • George, O., Koob, G. F. Control of craving by the prefrontal cortex Proceedings of the National Academy of Sciences of the United States of America  2013 110:4165-4166  DOI:10.1073/pnas.1301245110  PMID:23483010  PMCID:PMC3600441
    • Robison, A. J., Vialou, V., Mazei-Robison, M., Feng, J., Kourrich, S., Collins, M., Wee, S., Koob, G., Turecki, G., Neve, R., Thomas, M., Nestler, E. J. Behavioral and structural responses to chronic cocaine require a feedforward loop involving delta fosb and calcium/calmodulin-dependent protein kinase ii in the nucleus accumbens shell Journal of Neuroscience  2013 33:4295-4307  DOI:10.1523/jneurosci.5192-12.2013  PMID:23467346  PMCID:PMC3658178
    • Jang, C. G., Whitfield, T., Schulteis, G., Koob, G. F., Wee, S. A dysphoric-like state during early withdrawal from extended access to methamphetamine self-administration in rats Psychopharmacology  2013 225:753-763  DOI:10.1007/s00213-012-2864-0  PMID:23007601  PMCID:PMC3547144
    • Koob, G. F. Addiction is a reward deficit and stress surfeit disorder Frontiers in Psychiatry  2013 4:72  DOI:10.3389/fpsyt.2013.00072  PMID:23914176  PMCID:PMC3730086
    • Kreifeldt, M., Le, D., Treistman, S. N., Koob, G. F., Contet, C. BK channel beta1 and beta4 auxiliary subunits exert opposite influences on escalated ethanol drinking in dependent mice Frontiers in Integrative Neuroscience  2013 7:105  DOI:10.3389/fnint.2013.00105  PMID:24416005  PMCID:PMC3874544
    • De, B. P., Pagovich, O. E., Hicks, M. J., Rosenberg, J. B., Moreno, A. Y., Janda, K. D., Koob, G. F., Worgall, S., Kaminsky, S. M., Sondhi, D., Crystal, R. G. Disrupted adenovirus-based vaccines against small addictive molecules circumvent anti-adenovirus immunity Human Gene Therapy  2013 24:58-66  DOI:10.1089/hum.2012.163  PMID:23140508  PMCID:PMC3555097
    • Koob, G. F. Theoretical frameworks and mechanistic aspects of alcohol addiction: Alcohol addiction as a reward deficit disorder Current Topics in Behavioral Neurosciences  2013 13:3-30  DOI:10.1007/7854_2011_129  PMID:21744309  PMCID:PMC3448980
    • Lenoir, M., Guillem, K., Koob, G. F., Ahmed, S. H. Drug specificity in extended access cocaine and heroin self-administration Addiction Biology  2012 17:964-976  DOI:10.1111/j.1369-1600.2011.00385.x  PMID:21995515
    • George, O., Sanders, C., Freiling, J., Grigoryan, E., Vu, S., Allen, C. D., Crawford, E., Mandyam, C. D., Koob, G. F. Recruitment of medial prefrontal cortex neurons during alcohol withdrawal predicts cognitive impairment and excessive alcohol drinking Proceedings of the National Academy of Sciences of the United States of America  2012 109:18156-18161  DOI:10.1073/pnas.1116523109  PMID:23071333  PMCID:PMC3497825
    • Moreno, A. Y., Azar, M. R., Koob, G. F., Janda, K. D. Probing the protective effects of a conformationally constrained nicotine vaccine Vaccine  2012 30:6665-6670  DOI:10.1016/j.vaccine.2012.08.064  PMID:22963803
    • Goeders, N. E., Cohen, A., Fox, B. S., Azar, M. R., George, O., Koob, G. F. Effects of the combination of metyrapone and oxazepam on intravenous nicotine self-administration in rats Psychopharmacology  2012 223:17-25  DOI:10.1007/s00213-012-2682-4  PMID:22418732  PMCID:PMC3464482
    • Tobey, K. M., Walentiny, D. M., Wiley, J. L., Carroll, F. I., Damaj, M. I., Azar, M. R., Koob, G. F., George, O., Harris, L. S., Vann, R. E. Effects of the specific alpha 4 beta 2 nachr antagonist, 2-fluoro-3-(4-nitrophenyl) deschloroepibatidine, on nicotine reward-related behaviors in rats and mice Psychopharmacology  2012 223:159-168  DOI:10.1007/s00213-012-2703-3  PMID:22526534  PMCID:PMC3464481
    • Wee, S., Vendruscolo, L. F., Misra, K. K., Schlosburg, J. E., Koob, G. F. A combination of buprenorphine and naltrexone blocks compulsive cocaine intake in rodents without producing dependence Science Translational Medicine  2012 4:146ra110  DOI:10.1126/scitranslmed.3003948  PMID:22875830  PMCID:PMC3448552
    • Cohen, A., Koob, G. F., George, O. Robust escalation of nicotine intake with extended access to nicotine self-administration and intermittent periods of abstinence Neuropsychopharmacology  2012 37:2153-2160  DOI:10.1038/npp.2012.67  PMID:22549121  PMCID:PMC3398720
    • Higley, A. E., Koob, G. F., Mason, B. J. Treatment of alcohol dependence with drug antagonists of the stress response Alcohol Research: Current Reviews  2012 34:516-521  PMID:23584117  PMCID:PMC3860394
    • Vendruscolo, L. F., Barbier, E., Schlosburg, J. E., Misra, K. K., Whitfield, T. W., Logrip, M. L., Rivier, C., Repunte-Canonigo, V., Zorrilla, E. P., Sanna, P. P., Heilig, M., Koob, G. F. Corticosteroid-dependent plasticity mediates compulsive alcohol drinking in rats Journal of Neuroscience  2012 32:7563-7571  DOI:10.1523/jneurosci.0069-12.2012  PMID:22649234  PMCID:PMC3375621
    • Rosenberg, J. B., Hicks, M. J., De, B. P., Pagovich, O., Frenk, E., Janda, K. D., Wee, S., Koob, G. F., Hackett, N. R., Kaminsky, S. M., Worgall, S., Tignor, N., et al. AAVrh.10-mediated expression of an anti-cocaine antibody mediates persistent passive immunization that suppresses cocaine-induced behavior Human Gene Therapy  2012 23:451-459  DOI:10.1089/hum.2011.178  PMID:22486244  PMCID:PMC3360503
    • George, O., Le Moal, M., Koob, G. F. Allostasis and addiction: role of the dopamine and corticotropin-releasing factor systems Physiology and Behavior  2012 106:58-64  DOI:10.1016/j.physbeh.2011.11.004  PMID:22108506  PMCID:PMC3288230
    • Recinto, P., Samant, A. R. H., Chavez, G., Kim, A., Yuan, C. J., Soleiman, M., Grant, Y., Edwards, S., Wee, S., Koob, G. F., George, O., Mandyam, C. D. Levels of neural progenitors in the hippocampus predict memory impairment and relapse to drug seeking as a function of excessive methamphetamine self-administration Neuropsychopharmacology  2012 37:1275-1287  DOI:10.1038/npp.2011.315  PMID:22205547  PMCID:PMC3306889
    • Wee, S., Hicks, M. J., De, B. P., Rosenberg, J. B., Moreno, A. Y., Kaminsky, S. M., Janda, K. D., Crystal, R. G., Koob, G. F. Novel cocaine vaccine linked to a disrupted adenovirus gene transfer vector blocks cocaine psychostimulant and reinforcing effects Neuropsychopharmacology  2012 37:1083-1091  DOI:10.1038/npp.2011.200  PMID:21918504  PMCID:PMC3306868
    • Mandyam, C. D., Koob, G. F. The addicted brain craves new neurons: Putative role for adult-born progenitors in promoting recovery Trends in Neurosciences  2012 35:250-260  DOI:10.1016/j.tins.2011.12.005  PMID:22265158  PMCID:PMC3321119
    • Zorrilla, E. P., Wee, S., Zhao, Y., Specio, S., Boutrel, B., Koob, G. F., Weiss, F. Extended access cocaine self-administration differentially activates dorsal raphe and amygdala corticotropin-releasing factor systems in rats Addiction Biology  2012 17:300-308  DOI:10.1111/j.1369-1600.2011.00329.x  PMID:21762287  PMCID:PMC3304464
    • Edwards, S., Vendruscolo, L. F., Schlosburg, J. E., Misra, K. K., Wee, S., Park, P. E., Schulteis, G., Koob, G. F. Development of mechanical hypersensitivity in rats during heroin and ethanol dependence: Alleviation by crf1 receptor antagonism Neuropharmacology  2012 62:1142-1151  DOI:10.1016/j.neuropharm.2011.11.006  PMID:22119954  PMCID:PMC3262951
    • Logrip, M. L., Zorrilla, E. P., Koob, G. F. Stress modulation of drug self-administration: Implications for addiction comorbidity with post-traumatic stress disorder Neuropharmacology  2012 62:552-564  DOI:10.1016/j.neuropharm.2011.07.007  PMID:21782834  PMCID:PMC3206986
    • Edwards, S., Guerrero, M., Ghoneim, O. M., Roberts, E., Koob, G. F. Evidence that vasopressin V(1b) receptors mediate the transition to excessive drinking in ethanol-dependent rats Addiction Biology  2012 17:76-85  DOI:10.1111/j.1369-1600.2010.00291.x  PMID:21309953  PMCID:PMC3178679
    • Edwards, S., Koob, G. F. Experimental psychiatric illness and drug abuse models: from human to animal, an overview Methods in Molecular Biology  2012 829:31-48  DOI:10.1007/978-1-61779-458-2_2  PMID:22231805  PMCID:PMC3285446
    • Blednov, Y. A., Ponomarev, I., Geil, C., Bergeson, S., Koob, G. F., Harris, R. A. Neuroimmune regulation of alcohol consumption: Behavioral validation of genes obtained from genomic studies Addiction Biology  2012 17:108-120  DOI:10.1111/j.1369-1600.2010.00284.x  PMID:21309947  PMCID:PMC3117922
    • Koob, G., Hicks, M. J., Wee, S., Rosenberg, J. B., De, B. P., Kaminksy, S. M., Moreno, A., Janda, K. D., Crystal, R. G. Anti-cocaine vaccine based on coupling a cocaine analog to a disrupted adenovirus CNS and Neurological Disorders-Drug Targets  2011 10:899-904  PMID:22229312  PMCID:PMC3369545
    • Stowe, G. N., Schlosburg, J. E., Vendruscolo, L. F., Edwards, S., Misra, K. K., Schulteis, G., Zakhari, J. S., Koob, G. F., Janda, K. D. Developing a vaccine against multiple psychoactive targets: a case study of heroin CNS & Neurological Disorders-Drug Targets  2011 10:865-875  PMID:22229311  PMCID:PMC3327724
    • Fekete, E. M., Zhao, Y., Szucs, A., Sabino, V., Cottone, P., Rivier, J., Vale, W. W., Koob, G. F., Zorrilla, E. P. Systemic urocortin 2, but not urocortin 1 or stressin1-a, suppresses feeding via crf2 receptors without malaise and stress British Journal of Pharmacology  2011 164:1959-1975  DOI:10.1111/j.1476-5381.2011.01512.x  PMID:21627635  PMCID:PMC3246660
    • Contet, C., Gardon, O., Filliol, D., Becker, J. A. J., Koob, G. F., Kieffer, B. L. Identification of genes regulated in the mouse extended amygdala by excessive ethanol drinking associated with dependence Addiction Biology  2011 16:615-619  DOI:10.1111/j.1369-1600.2010.00304.x  PMID:21392173  PMCID:PMC3139763
    • Mihindou, C., Vouillac, C., Koob, G. F., Ahmed, S. H. Preclinical validation of a novel cocaine exposure therapy for relapse prevention Biological Psychiatry  2011 70:593-598  DOI:10.1016/j.biopsych.2011.03.036  PMID:21571256  PMCID:PMC3157564
    • Stowe, G. N., Vendruscolo, L. F., Edwards, S., Schlosburg, J. E., Misra, K. K., Schulteis, G., Mayorov, A. V., Zakhari, J. S., Koob, G. F., Janda, K. D. A vaccine strategy that induces protective immunity against heroin Journal of Medicinal Chemistry  2011 54:5195-5204  DOI:10.1021/jm200461m  PMID:21692508  PMCID:PMC3142939
    • Parylak, S. L., Koob, G. F., Zorrilla, E. P. The dark side of food addiction Physiology & Behavior  2011 104:149-156  DOI:10.1016/j.physbeh.2011.04.063  PMID:21557958  PMCID:PMC3304465
    • Vendruscolo, L. F., Schlosburg, J. E., Misra, K. K., Chen, S. A., Greenwell, T. N., Koob, G. F. Escalation patterns of varying periods of heroin access Pharmacology, Biochemistry and Behavior  2011 98:570-574  DOI:10.1016/j.pbb.2011.03.004  PMID:21406200  PMCID:PMC3081940
    • Allen, C. D., Lee, S., Koob, G. F., Rivier, C. Immediate and prolonged effects of alcohol exposure on the activity of the hypothalamic-pituitary-adrenal axis in adult and adolescent rats Brain Behavior and Immunity  2011 25:S50-S60  DOI:10.1016/j.bbi.2011.01.016  PMID:21300146  PMCID:PMC3098294
    • Gilpin, N. W., Misra, K., Herman, M. A., Cruz, M. T., Koob, G. F., Roberto, M. Neuropeptide y opposes alcohol effects on gamma-aminobutyric acid release in amygdala and blocks the transition to alcohol dependence Biological Psychiatry  2011 69:1091-1099  DOI:10.1016/j.biopsych.2011.02.004  PMID:21459365  PMCID:PMC3090491
    • Sabino, V., Cottone, P., Blasio, A., Iyer, M. R., Steardo, L., Rice, K. C., Conti, B., Koob, G. F., Zorrilla, E. P. Activation of σ-receptors induces binge-like drinking in Sardinian alcohol-preferring rats Neuropsychopharmacology  2011 36:1207-1218  DOI:10.1038/npp.2011.5  PMID:21346735  PMCID:PMC3079320
    • George, O., Koob, G. F. Craving, context and the cortex Nature Neuroscience  2011 14:409-410  DOI:10.1038/nn.2787  PMID:21445066  PMCID:PMC3829767
    • Hicks, M. J., De, B. P., Rosenberg, J. B., Davidson, J. T., Moreno, A. Y., Janda, K. D., Wee, S., Koob, G. F., Hackett, N. R., Kaminsky, S. M., Worgall, S., Toth, M., et al. Cocaine analog coupled to disrupted adenovirus: A vaccine strategy to evoke high-titer immunity against addictive drugs Molecular Therapy  2011 19:612-619  DOI:10.1038/mt.2010.280  PMID:21206484  PMCID:PMC3048190
    • Ali, S. F., Onaivi, E. S., Dodd, P. R., Cadet, J. L., Schenk, S., Kuhar, M. J., Koob, G. F. Understanding the global problem of drug addiction is a challenge for IDARS scientists Current Neuropharmacology  2011 9:2-7  DOI:10.2174/157015911795017245  PMID:21886551  PMCID:PMC3137181
    • George, O., Lloyd, A., Carroll, F. I., Damaj, M. I., Koob, G. F. Varenicline blocks nicotine intake in rats with extended access to nicotine self-administration Psychopharmacology  2011 213:715-722  DOI:10.1007/s00213-010-2024-3  PMID:20924754  PMCID:PMC3033995
    • Logrip, M. L., Koob, G. F., Zorrilla, E. P. Role of corticotropin-releasing factor in drug addiction potential for pharmacological intervention CNS Drugs  2011 25:271-287  DOI:10.2165/11587790-000000000-00000  PMID:21425881  PMCID:PMC3273042
    • Walker, B. M., Zorrilla, E. P., Koob, G. F. Systemic kappa-opioid receptor antagonism by nor-binaltorphimine reduces dependence-induced excessive alcohol self-administration in rats Addiction Biology  2011 16:116-119  DOI:10.1111/j.1369-1600.2010.00226.x  PMID:20579007  PMCID:PMC2988980
    • George, O., Koob, G. F. Individual differences in prefrontal cortex function and the transition from drug use to drug dependence Neuroscience and Biobehavioral Reviews  2010 35:232-247  DOI:10.1016/j.neubiorev.2010.05.002  PMID:20493211  PMCID:PMC2955797
    • Gilpin, N. W., Koob, G. F. Effects of beta-adrenoceptor antagonists on alcohol drinking by alcohol-dependent rats Psychopharmacology  2010 212:431-439  DOI:10.1007/s00213-010-1967-8  PMID:20676608  PMCID:PMC2966867
    • George, O., Grieder, T. E., Cole, M., Koob, G. F. Exposure to chronic intermittent nicotine vapor induces nicotine dependence Pharmacology, Biochemistry and Behavior  2010 96:104-107  DOI:10.1016/j.pbb.2010.04.013  PMID:20420848  PMCID:PMC2878929
    • Orio, L., Wee, S., Newman, A. H., Pulvirenti, L., Koob, G. F. The dopamine d3 receptor partial agonist cjb090 and antagonist pg01037 decrease progressive ratio responding for methamphetamine in rats with extended-access Addiction Biology  2010 15:312-323  DOI:10.1111/j.1369-1600.2010.00211.x  PMID:20456290  PMCID:PMC2903631
    • Wee, S., Koob, G. F. The role of the dynorphin-kappa opioid system in the reinforcing effects of drugs of abuse Psychopharmacology  2010 210:121-135  DOI:10.1007/s00213-010-1825-8  PMID:20352414  PMCID:PMC2879894
    • Roberto, M., Cruz, M. T., Gilpin, N. W., Sabin, V., Schweitzer, P., Bajo, M., Cottone, P., Madamba, S. G., Stouffer, D. G., Zorrilla, E. P., Koob, G. F., Siggins, G. R., et al. Corticotropin releasing factor-induced amygdala gamma-aminobutyric acid release plays a key role in alcohol dependence Biological Psychiatry  2010 67:831-839  DOI:10.1016/j.biopsych.2009.11.007  PMID:20060104  PMCID:PMC2883449
    • Zorrilla, E. P., Koob, G. F. Progress in corticotropin-releasing factor-1 antagonist development Drug Discovery Today  2010 15:371-383  DOI:10.1016/j.drudis.2010.02.011  PMID:20206287  PMCID:PMC2864802
    • Moreno, A. Y., Azar, M. R., Warren, N. A., Dickerson, T. J., Koob, G. F., Janda, K. D. A critical evaluation of a nicotine vaccine within a self-administration behavioral model Molecular Pharmaceutics  2010 7:431-441  DOI:10.1021/mp900213u  PMID:20104903
    • Koob, G. F. The role of crf and crf-related peptides in the dark side of addiction Brain Research  2010 1314:3-14  DOI:10.1016/j.brainres.2009.11.008  PMID:19912996  PMCID:PMC2819562
    • Koob, G. F., Zorrilla, E. P. Neurobiological mechanisms of addiction: Focus on corticotropin-releasing factor Current Opinion in Investigational Drugs  2010 11:63-71  PMID:20047160  PMCID:PMC2812895
    • Koob, G. F., Volkow, N. D. Neurocircuitry of addiction Neuropsychopharmacology  2010 35:217-238  DOI:10.1038/npp.2009.110  PMID:19710631  PMCID:PMC2805560
    • Shurman, J., Koob, G. F., Gutstein, H. B. Opioids, pain, the brain, and hyperkatifeia: a framework for the rational use of opioids for pain Pain Medicine  2010 11:1092-1098  DOI:10.1111/j.1526-4637.2010.00881.x  PMID:20545871  PMCID:PMC2907890
    • Gilpin, N. W., Smith, A. D., Cole, M., Weiss, F., Koob, G. F., Richardson, H. N. Operant behavior and alcohol levels in blood and brain of alcohol-dependent rats Alcoholism-Clinical and Experimental Research  2009 33:2113-2123  DOI:10.1111/j.1530-0277.2009.01051.x  PMID:19740131  PMCID:PMC2789881
    • Cottone, P., Sabino, V., Roberto, M., Bajo, M., Pockros, L., Frihauf, J. B., Fekete, E. M., Steardo, L., Rice, K. C., Grigoriadis, D. E., Conti, B., Koob, G. F., et al. CRF system recruitment mediates dark side of compulsive eating Proceedings of the National Academy of Sciences of the United States of America  2009 106:20016-20020  DOI:10.1073/pnas.0908789106  PMID:19901333  PMCID:PMC2785284
    • Francesconi, W., Berton, F., Koob, G. F., Sanna, P. P. Intrinsic neuronal plasticity in the juxtacapsular nucleus of the bed nuclei of the stria terminalis (jcBNST) Progress in Neuro-Psychopharmacology & Biological Psychiatry  2009 33:1347-1355  DOI:10.1016/j.pnpbp.2009.08.003  PMID:19683025  PMCID:PMC2935256
    • Tabakoff, B., Saba, L., Printz, M., Flodman, P., Hodgkinson, C., Goldman, D., Koob, G., Richardson, H. N., Kechris, K., Bell, R. L., Hubner, N., Heinig, M., et al. Genetical genomic determinants of alcohol consumption in rats and humans BMC Biology  2009 7:70  DOI:10.1186/1741-7007-7-70  PMID:19874574  PMCID:PMC2777866
    • Koob, G. F. Brain stress systems in the amygdala and addiction Brain Research  2009 1293:61-75  DOI:10.1016/j.brainres.2009.03.038  PMID:19332030  PMCID:PMC2774745
    • Richardson, H. N., Chan, S. H., Crawford, E. F., Lee, Y. K., Funk, C. K., Koob, G. F., Mandyam, C. D. Permanent impairment of birth and survival of cortical and hippocampal proliferating cells following excessive drinking during alcohol dependence Neurobiology of Disease  2009 36:1-10  DOI:10.1016/j.nbd.2009.05.021  PMID:19501165  PMCID:PMC2742572
    • Wee, S., Orio, L., Ghirmai, S., Cashman, J. R., Koob, G. F. Inhibition of kappa opioid receptors attenuated increased cocaine intake in rats with extended access to cocaine Psychopharmacology  2009 205:565-575  DOI:10.1007/s00213-009-1563-y  PMID:19484223  PMCID:PMC2739447
    • Sabino, V., Cottone, P., Zhao, Y., Steardo, L., Koob, G. F., Zorrilla, E. P. Selective reduction of alcohol drinking in sardinian alcohol-preferring rats by a sigma-1 receptor antagonist Psychopharmacology  2009 205:327-335  DOI:10.1007/s00213-009-1548-x  PMID:19440699  PMCID:PMC2748837
    • Koob, G. F., Lloyd, G. K., Mason, B. J. Development of pharmacotherapies for drug addiction: a Rosetta stone approach Nature Reviews Drug Discovery  2009 8:500-515  DOI:10.1038/nrd2828  PMID:19483710  PMCID:PMC2760328
    • Sabino, V., Cottone, P., Zhao, Y., Iyer, M. R., Steardo, L., Rice, K. C., Conti, B., Rice, K. C., Koob, G. F., Zorrilla, E. P. The sigma-receptor antagonist BD-1063 decreases ethanol intake and reinforcement in animal models of excessive drinking Neuropsychopharmacology  2009 34:1482-1493  DOI:10.1038/npp.2008.192  PMID:18946467  PMCID:PMC2669694
    • Francesconi, W., Berton, F., Repunte-Canonigo, V., Hagihara, K., Thurbon, D., Lekic, D., Specio, S. E., Greenwell, T. N., Chen, S. A., Rice, K. C., Richardson, H. N., O'Dell, L. E., et al. Protracted withdrawal from alcohol and drugs of abuse impairs long-term potentiation of intrinsic excitability in the juxtacapsular bed nucleus of the stria terminalis Journal of Neuroscience  2009 29:5389-5401  DOI:10.1523/jneurosci.5129-08.2009  PMID:19403807  PMCID:PMC2938175
    • Orio, L., Edwards, S., George, O., Parsons, L. H., Koob, G. F. A role for the endocannabinoid system in the increased motivation for cocaine in extended-access conditions Journal of Neuroscience  2009 29:4846-4857  DOI:10.1523/jneurosci.0563-09.2009  PMID:19369553  PMCID:PMC2688678
    • Greenwell, T. N., Funk, C. K., Cottone, P., Richardson, H. N., Chen, S. A., Rice, K. C., Zorrilla, E. P., Koob, G. F. Corticotropin-releasing factor-1 receptor antagonists decrease heroin self-administration in long- but not short-access rats Addiction Biology  2009 14:130-143  DOI:10.1111/j.1369-1600.2008.00142.x  PMID:19291009  PMCID:PMC2748834
    • Koob, G. F. Dynamics of neuronal circuits in addiction: Reward, antireward, and emotional memory Pharmacopsychiatry  2009 42:S32-S41  DOI:10.1055/s-0029-1216356  PMID:19434554  PMCID:PMC2739305
    • Koob, G. F. Neurobiological substrates for the dark side of compulsivity in addiction Neuropharmacology  2009 56:18-31  DOI:10.1016/j.neuropharm.2008.07.043  PMID:18725236  PMCID:PMC2637927
    • Koob, G. F. New dimensions in human laboratory models of addiction Addiction Biology  2009 14:1-8  DOI:10.1111/j.1369-1600.2008.00127.x  PMID:19133879
    • Greenwell, T. N., Walker, B. M., Cottone, P., Zorrilla, E. P., Koob, G. F. The alpha(1) adrenergic receptor antagonist prazosin reduces heroin self-administration in rats with extended access to heroin administration Pharmacology, Biochemistry and Behavior  2009 91:295-302  DOI:10.1016/j.pbb.2008.07.012  PMID:18703080  PMCID:PMC2637926
    • Mandyam, C. D., Wee, S., Crawford, E. F., Eisch, A. J., Richardson, H. N., Koob, G. F. Varied access to intravenous methamphetamine self-administration differentially alters adult hippocampal neurogenesis Biological Psychiatry  2008 64:958-965  DOI:10.1016/j.biopsych.2008.04.010  PMID:18490002  PMCID:PMC2587157
    • Papaleo, F., Ghozland, S., Ingallinesi, M., Roberts, A. J., Koob, G. F., Contarino, A. Disruption of the CRF(2) receptor pathway decreases the somatic expression of opiate withdrawal Neuropsychopharmacology  2008 33:2878-2887  DOI:10.1038/npp.2008.8  PMID:18288089  PMCID:PMC2760329
    • Koob, G. F., Le Moal, M. Neurobiological mechanisms for opponent motivational processes in addiction Philosophical Transactions of the Royal Society B-Biological Sciences  2008 363:3113-3123  DOI:10.1098/rstb.2008.0094  PMID:18653439  PMCID:PMC2607326
    • Richardson, H. N., Lee, S. Y., O'Dell, L. E., Koob, G. F., Rivier, C. L. Alcohol self-administration acutely stimulates the hypothalamic-pituitary-adrenal axis, but alcohol dependence leads to a dampened neuroendocrine state European Journal of Neuroscience  2008 28:1641-1653  DOI:10.1111/j.1460-9568.2008.06455.x  PMID:18979677  PMCID:PMC2748838
    • Du, X., Schwander, M., Moresco, E. M. Y., Viviani, P., Haller, C., Hildebrand, M. S., Pak, K., Tarantino, L., Roberts, A., Richardson, H., Koob, G., Najmabadi, H., et al. A catechol-O-methyltransferase that is essential for auditory function in mice and humans Proceedings of the National Academy of Sciences of the United States of America  2008 105:14609-14614  DOI:10.1073/pnas.0807219105  PMID:18794526  PMCID:PMC2567147
    • Gilpin, N. W., Richardson, H. N., Lumeng, L., Koob, G. F. Dependence-induced alcohol drinking by alcohol-preferring (p) rats and outbred wistar rats Alcoholism-Clinical and Experimental Research  2008 32:1688-1696  DOI:10.1111/j.1530-0277.2008.00678.x  PMID:18482158  PMCID:PMC2583092
    • Gilpin, N. W., Richardson, H. N., Koob, G. F. Effects of crf(1)-receptor and opioid-receptor antagonists on dependence-induced increases in alcohol drinking by alcohol-preferring (p) rats Alcoholism-Clinical and Experimental Research  2008 32:1535-1542  DOI:10.1111/j.1530-0277.2008.00745.x  PMID:18631323  PMCID:PMC2583093
    • George, O., Mandyam, C. D., Wee, S., Koob, G. F. Extended access to cocaine self-administration produces long-lasting prefrontal cortex-dependent working memory impairments Neuropsychopharmacology  2008 33:2474-2482  DOI:10.1038/sj.npp.1301626  PMID:18033234  PMCID:PMC2760333
    • Gilpin, N. W., Misra, K., Koob, G. F. Neuropeptide y in the central nucleus of the amygdala suppresses dependence-induced increases in alcohol drinking Pharmacology, Biochemistry and Behavior  2008 90:475-480  DOI:10.1016/j.pbb.2008.04.006  PMID:18501411  PMCID:PMC2480495
    • Koob, G. F. A role for brain stress systems in addiction Neuron  2008 59:11-34  DOI:10.1016/j.neuron.2008.06.012  PMID:18614026  PMCID:PMC2748830
    • Roberto, M., Gilpin, N. W., O'Dell, L. E., Cruz, M. T., Morse, A. C., Siggins, G. R., Koob, G. F. Cellular and behavioral interactions of gabapentin with alcohol dependence Journal of Neuroscience  2008 28:5762-5771  DOI:10.1523/jneurosci.0575-08.2008  PMID:18509038  PMCID:PMC2493536
    • Wee, S., Mandyam, C. D., Lekic, D. M., Koob, G. F. Alpha(1)-noradrenergic system role in increased motivation for cocaine intake in rats with prolonged access European Neuropsychopharmacology  2008 18:303-311  DOI:10.1016/j.euroneuro.2007.08.003  PMID:17920248  PMCID:PMC2376122
    • Walker, B. M., Rasmussen, D. D., Raskind, M. A., Koob, G. F. Alpha(1)-noradrenergic receptor antagonism blocks dependence-induced increases in responding for ethanol Alcohol  2008 42:91-97  DOI:10.1016/j.alcohol.2007.12.002  PMID:18358987  PMCID:PMC2587143
    • Specio, S. E., Wee, S., O'Dell, L. E., Boutrel, B., Zorrilla, E. P., Koob, G. F. Crf1 receptor antagonists attenuate escalated cocaine self-administration in rats Psychopharmacology  2008 196:473-482  DOI:10.1007/s00213-007-0983-9  PMID:17965976  PMCID:PMC2769571
    • Ji, D., Gilpin, N. W., Richardson, H. N., Rivier, C. L., Koob, G. F. Effects of naltrexone, duloxetine, and a corticotropin-releasing factor type 1 receptor antagonist on binge-like alcohol drinking in rats Behavioural Pharmacology  2008 19:1-12  DOI:10.1097/FBP.0b013e3282f3cf70  PMID:18195589  PMCID:PMC2586833
    • Richardson, H. N., Zhao, Y., Fekete, E. M., Funk, C. K., Wirsching, P., Janda, K. D., Zorrilla, E. P., Koob, G. F. MPZP: A novel small molecule corticotropin-releasing factor type 1 receptor (CRF1) antagonist Pharmacology, Biochemistry and Behavior  2008 88:497-510  DOI:10.1016/j.pbb.2007.10.008  PMID:18031798  PMCID:PMC3319109
    • Walker, B. M., Koob, G. F. Pharmacological evidence for a motivational role of kappa-opioid systems in ethanol dependence Neuropsychopharmacology  2008 33:643-652  DOI:10.1038/sj.npp.1301438  PMID:17473837  PMCID:PMC2739278
    • Guillem, K., Vouillac, C., Koob, G. F., Cador, M., Stinus, L. Monoamine oxidase inhibition dramatically prolongs the duration of nicotine withdrawal-induced place aversion Biological Psychiatry  2008 63:158-163  DOI:10.1016/j.biopsych.2007.04-029  PMID:17643399
    • Caine, S. B., Thomsen, M., Gabriel, K. I., Berkowitz, J. S., Gold, L. H., Koob, G. F., Tonegawa, S., Zhang, J. H., Xu, M. Lack of self-administration of cocaine in dopamine d-1 receptor knock-out mice Journal of Neuroscience  2007 27:13140-13150  DOI:10.1523/jneurosci.2284-07.2007  PMID:18045908
    • Zhang, Z., Morse, A. C., Koob, G. F., Schulteis, G. Dose- and time-dependent expression of anxiety-like behavior in the elevated plus-maze during withdrawal from acute and repeated intermittent ethanol intoxication in rats Alcoholism-Clinical and Experimental Research  2007 31:1811-1819  DOI:10.1111/j.1530-0277.2007.00483.x  PMID:17877783  PMCID:PMC2367334
    • George, O., Ghozland, S., Azar, M. R., Cottone, P., Zorrilla, E. P., Parsons, L. H., O'Dell, L. E., Richardson, H. N., Koob, G. F. CRF-CRF1 system activation mediates withdrawal-induced increases in nicotine self-administration in nicotine-dependent rats Proceedings of the National Academy of Sciences of the United States of America  2007 104:17198-17203  DOI:10.1073/pnas.0707585104  PMID:17921249  PMCID:PMC2040467
    • Mandyam, C. D., Wee, S., Eisch, A. J., Richardson, H. N., Koob, G. F. Methamphetamine self-administration and voluntary exercise have opposing effects on medial prefrontal cortex gliogenesis Journal of Neuroscience  2007 27:11442-11450  DOI:10.1523/jneurosci.2505-07.2007  PMID:17942739
    • Wee, S., Wang, Z., Woolverton, W. L., Pulvirenti, L., Koob, G. F. Effect of aripiprazole, a partial dopamine d-2 receptor agonist, on increased rate of methamphetamine self-administration in rats with prolonged session duration Neuropsychopharmacology  2007 32:2238-2247  DOI:10.1038/sj.npp.1301353  PMID:17327886  PMCID:PMC2747088
    • Tabarin, A., Diz-Chaves, Y., Consoli, D., Monsaingeon, M., Bale, T. L., Culler, M. D., Datta, R., Drago, F., Vale, W. W., Koob, G. F., Zorrilla, E. P., Contarino, A. Role of the corticotropin-releasing factor receptor type 2 in the control of food intake in mice: A meal pattern analysis European Journal of Neuroscience  2007 26:2303-2314  DOI:10.1111/j.1460-9568.2007.05856.x  PMID:17953621  PMCID:PMC2741498
    • Heilig, M., Koob, G. F. A key role for corticotropin-releasing factor in alcohol dependence Trends in Neurosciences  2007 30:399-406  DOI:10.1016/j.tins.2007.06.006  PMID:17629579  PMCID:PMC2747092
    • Koob, G., Kreek, M. J. Stress, dysregulation of drug reward pathways, and the transition to drug dependence American Journal of Psychiatry  2007 164:1149-1159  DOI:10.1176/appi.ajp.2007.05030503  PMID:17671276  PMCID:PMC2837343
    • Treweek, J., Wee, S., Koob, G. F., Dickerson, T. J., Janda, K. D. Self-vaccination by methamphetamine glycation products chemically links chronic drug abuse and cardiovascular disease Proceedings of the National Academy of Sciences of the United States of America  2007 104:11580-11584  DOI:10.1073/pnas.0701328104  PMID:17592122  PMCID:PMC1913859
    • Funk, C. K., Koob, G. F. A crf2 agonist administered into the central nucleus of the amygdala decreases ethanol self-administration in ethanol-dependent rats Brain Research  2007 1155:172-178  DOI:10.1016/j.brainres.2007.04.009  PMID:17512918  PMCID:PMC2741495
    • Fekete, E. M., Inoue, K., Zhao, Y., Rivier, J. E., Vale, W. W., Szucs, A., Koob, G. F., Zorrilla, E. P. Delayed satiety-like actions and altered feeding microstructure by a selective type 2 corticotropin-releasing factor agonist in rats: Intra-hypothalamic urocortin 3 administration reduces food intake by prolonging the post-meal interval Neuropsychopharmacology  2007 32:1052-1068  DOI:10.1038/sj.npp.1301214  PMID:17019404  PMCID:PMC2748839
    • Le Moal, M., Koob, G. F. Drug addiction: Pathways to the disease and pathophysiological perspectives European Neuropsychopharmacology  2007 17:377-393  DOI:10.1016/j.euroneuro.2006.10.006  PMID:171695
    • Thorsell, A., Repunte-Canonigo, V., O'Dell, L. E., Chen, S. A., King, A. R., Lekic, D., Koob, G. F., Sanna, P. P. Viral vector-induced amygdala NPY overexpression reverses increased alcohol intake caused by repeated deprivations in Wistar rats Brain  2007 130:1330-1337  DOI:10.1093/brain/awm033  PMID:17405766  PMCID:PMC2749684
    • Chu, K., Koob, G. F., Cole, M., Zorrilla, E. P., Roberts, A. J. Dependence-induced increases in ethanol self-administration in mice are blocked by the crf, receptor antagonist antalarmin and by crf, receptor knockout Pharmacology, Biochemistry and Behavior  2007 86:813-821  DOI:10.1016/j.pbb.2007.03.009  PMID:17482248  PMCID:PMC2170886
    • Brogan, A. P., Eubanks, L. M., Koob, G. F., Dickerson, T. J., Janda, K. D. Antibody-catalyzed oxidation of delta(9)-tetrahydrocannabinol Journal of the American Chemical Society  2007 129:3698-3702  DOI:10.1021/ja070022m  PMID:17335216
    • Wee, S., Specio, S. E., Koob, G. F. Effects of dose and session duration on cocaine self-administration in rats Journal of Pharmacology and Experimental Therapeutics  2007 320:1134-1143  DOI:10.1124/jpet.106.113340  PMID:17202405
    • O'Dell, L. E., Koob, G. F. 'Nicotine deprivation effect' in rats with intermittent 23-hour access to intravenous nicotine self-administration Pharmacology, Biochemistry and Behavior  2007 86:346-353  DOI:10.1016/j.pbb.2007.01.004  PMID:17292952  PMCID:PMC2386418
    • Solbrig, M. V., Adrian, R., Wechsler, S. L., Koob, G. F. Activators of potassium m currents have anticonvulsant actions in two rat models of encephalitis European Journal of Pharmacology  2007 555:23-29  DOI:10.1016/j.ejphar.2006.10.025  PMID:17126318  PMCID:PMC2981072
    • Funk, C. K., Zorrilla, E. P., Lee, M. J., Rice, K. C., Koob, G. F. Corticotropin-releasing factor 1 antagonists selectively reduce ethanol self-administration in ethanol-dependent rats Biological Psychiatry  2007 61:78-86  DOI:10.1016/j.biopsych.2006.03.063  PMID:16876134  PMCID:PMC2741496
    • O'Dell, L. E., Chen, S. A., Smith, R. T., Specio, S. E., Balster, R. L., Paterson, N. E., Markou, A., Zorrilla, E. P., Koob, G. F. Extended access to nicotine self-administration leads to dependence: Circadian measures, withdrawal measures, and extinction behavior in rats Journal of Pharmacology and Experimental Therapeutics  2007 320:180-193  DOI:10.1124/jpet.106.105270  PMID:17050784
    • Walker, B. M., Koob, G. F. The gamma-aminobutyric acid-b receptor agonist baclofen attenuates responding for ethanol in ethanol-dependent rats Alcoholism-Clinical and Experimental Research  2007 31:11-18  DOI:10.1111/j.1530-0277.2006.00259.x  PMID:17207096  PMCID:PMC2768469
    • Sabino, V., Cottone, P., Koob, G. F., Steardo, L., Lee, M. J., Rice, K. C., Zorrilla, E. P. Dissociation between opioid and crf1 antagonist sensitive drinking in sardinian alcohol-preferring rats Psychopharmacology  2006 189:175-186  DOI:10.1007/s00213-006-0546-5  PMID:17047935
    • Guillem, K., Vouillac, C., Azar, M. R., Parsons, L. H., Koob, G. F., Cador, M., Stinus, L. Monoamine oxidase A rather than monoamine oxidase B inhibition increases nicotine reinforcement in rats European Journal of Neuroscience  2006 24:3532-3540  DOI:10.1111/j.1460-9568.2006.05217.x  PMID:17229101
    • Eubanks, L. M., Rogers, C. J., Beuscher, A. E., Koob, G. F., Olson, A. J., Dickerson, T. J., Janda, K. D. A molecular link between the active component of marijuana and Alzheimer's disease pathology Molecular Pharmaceutics  2006 3:773-777  DOI:10.1021/mp060066m  PMID:17140265  PMCID:PMC2562334
    • Steffensen, S. C., Stobbs, S. H., Colago, E. E. O., Lee, R. S., Koob, G. F., Gallegos, R. A., Henriksen, S. J. Contingent and non-contingent effects of heroin on mu-opioid receptor-containing ventral tegmental area gaba neurons Experimental Neurology  2006 202:139-151  DOI:10.1016/j.expneurol.2006.05.023  PMID:16814775
    • Funk, C. K., O'Dell, L. E., Crawford, E. F., Koob, G. F. Corticotropin-releasing factor within the central nucleus of the amygdala mediates enhanced ethanol self-administration in withdrawn, ethanol-dependent rats Journal of Neuroscience  2006 26:11324-11332  DOI:10.1523/jneurosci.3096-06.2006  PMID:17079660
    • Crabbe, J. C., Phillips, T. J., Harris, R. A., Arends, M. A., Koob, G. F. Alcohol-related genes: Contributions from studies with genetically engineered mice Addiction Biology  2006 11:195-269  DOI:10.1111/j.1369-1600.2006.00038.x  PMID:16961758
    • Koob, G. F. The neurobiology of addiction: A neuroadaptational view relevant for diagnosis Addiction  2006 101:23-30  DOI:10.1111/j.1360-0443.2006.01586.x  PMID:16930158
    • O'Dell, L. E., Bruijnzeel, A. W., Smith, R. T., Parsons, L. H., Merves, M. L., Goldberger, B. A., Richardson, H. N., Koob, G. F., Markou, A. Diminished nicotine withdrawal in adolescent rats: implications for vulnerability to addiction Psychopharmacology  2006 186:612-619  DOI:10.1007/s00213-006-0383-6  PMID:16598454
    • Kenny, P. J., Chen, S. A., Kitamura, O., Markou, A., Koob, G. F. Conditioned withdrawal drives heroin consumption and decreases reward sensitivity Journal of Neuroscience  2006 26:5894-5900  DOI:10.1523/jneurosci.0740-06.2006  PMID:16738231
    • Kitamura, O., Wee, S., Specio, S. E., Koob, G. F., Pulvirenti, L. Escalation of methamphetamine self-administration in rats: A dose-effect function Psychopharmacology  2006 186:48-53  DOI:10.1007/s00213-006-0353-z  PMID:16552556
    • Mulligan, M. K., Ponomarev, I., Hitzemann, R. J., Belknap, J. K., Tabakoff, B., Harris, R. A., Crabbe, J. C., Blednov, Y. A., Grahame, N. J., Phillips, T. J., Finn, D. A., Hoffman, P. L., et al. Toward understanding the genetics of alcohol drinking through transcriptome meta-analysis Proceedings of the National Academy of Sciences of the United States of America  2006 103:6368-6373  DOI:10.1073/pnas.0510188103  PMID:16618939  PMCID:PMC1458884
    • Hoefer, M. E., Voskanian, S. J., Koob, G. F., Pulvirenti, L. Effects of terguride, ropinirole, and acetyl-l-carnitine on methamphetamine withdrawal in the rat Pharmacology, Biochemistry and Behavior  2006 83:403-409  DOI:10.1016/j.pbb.2006.02.023  PMID:16647107
    • Solbrig, M. V., Adrian, R., Baratta, J., Lauterborn, J. C., Koob, G. F. Kappa opioid control of seizures produced by a virus in an animal model Brain  2006 129:642-654  DOI:10.1093/brain/awl008  PMID:16399805
    • Johnson, B. A., Koob, G. F., Schuckit, M. A., Mason, B. J., Ait-Daoud, N. Understanding and treating alcohol dependence Alcoholism-Clinical and Experimental Research  2006 30:567-584  DOI:10.1111/j.1530-0277.2005.00066.x  PMID:16499499
    • Kranzler, H. R., Koob, G., Gastfriend, D. R., Swift, R. M., Willenbring, M. L. Advances in the pharmacotherapy of alcoholism: Challenging misconceptions Alcoholism-Clinical and Experimental Research  2006 30:272-281  DOI:10.1111/j.1530-0277.2006.00022.x  PMID:16441276
    • Chen, S. A., O'Dell, L. E., Hoefer, M. E., Greenwell, T. N., Zorrilla, E. P., Koob, G. F. Unlimited access to heroin self-administration: Independent motivational markers of opiate dependence Neuropsychopharmacology  2006 31:2692-2707  DOI:10.1038/sj.npp.1301008  PMID:16452
    • Boutrel, B., Kenny, P. J., Specio, S. E., Martin-Fardon, R., Markou, A., Koob, G. F., de Lecea, L. Role for hypocretin in mediating stress-induced reinstatement of cocaine-seeking behavior Proceedings of the National Academy of Sciences of the United States of America  2005 102:19168-19173  DOI:10.1073/pnas.0507480102  PMID:16357203  PMCID:PMC1323172
    • Tabarin, A., Chaves, Y. D., Carmona, M. D., Catargi, B., Zorrilla, E. P., Roberts, A. J., Coscina, D. V., Rousset, S., Redonnet, A., Parker, G. C., Inoue, K., Ricquier, D., et al. Resistance to diet-induced obesity in mu-opioid receptor-deficient mice: Evidence for a "thrifty gene" Diabetes  2005 54:3510-3516  DOI:10.2337/diabetes.54.12.3510  PMID:16306369
    • Qi, L. W., Yamamoto, N., Meijler, M. M., Altobell, L. J., Koob, G. F., Wirsching, P., Janda, K. D. Delta(9)-tetrahydrocannabinol immunochemical studies: Haptens, monoclonal antibodies, and a convenient synthesis of radiolabeled delta(9)-tetrahydrocannabinol Journal of Medicinal Chemistry  2005 48:7389-7399  DOI:10.1021/jm050442r  PMID:16279798
    • Koob, G. F. The neurocircuitry of addiction: implications for treatment Clinical Neuroscience Research  2005 5:89-101  DOI:10.1016/j.cnr.2005.08.005
    • Guillem, K., Vouillac, C., Azar, M. R., Parsons, L. H., Koob, G. F., Cador, M., Stinus, L. Monoamine oxidase inhibition dramatically increases the motivation to self-administer nicotine in rats Journal of Neuroscience  2005 25:8593-8600  DOI:10.1523/jneurosci.2139-05.2005  PMID:16177026
    • Ahmed, S. H., Lutjens, R., van der Stap, L. D., Lekic, D., Romano-Spica, V., Morales, M., Koob, G. F., Repunte-Canonigo, V., Sanna, P. P. Gene expression evidence for remodeling of lateral hypothalamic circuitry in cocaine addiction Proceedings of the National Academy of Sciences of the United States of America  2005 102:11533-11538  DOI:10.1073/pnas.0504438102  PMID:16076954  PMCID:PMC1183574
    • Valdez, G. R., Zorrilla, E. P., Koob, G. F. Homeostasis within the corticotropin-releasing factor system via crf2 receptor activation: A novel approach for the treatment of anxiety Drug Development Research  2005 65:205-215  DOI:10.1002/ddr.20024
    • Izzo, E., Sanna, P. P., Koob, G. F. Impairment of dopaminergic system function after chronic treatment with corticotropin-releasing factor Pharmacology, Biochemistry and Behavior  2005 81:701-708  DOI:10.1016/j.pbb.2005.04.017  PMID:16005056
    • Sanchis-Segura, C., Grisel, J. E., Olive, M. F., Ghozland, S., Koob, G. F., Roberts, A. J., Cowen, M. S. Role of the endogenous opioid system on the neuropsychopharmacological effects of ethanol: New insights about an old question Alcoholism-Clinical and Experimental Research  2005 29:1522-1527  DOI:10.1097/01.alc.0000174913.60384.e8  PMID:16156049
    • O'Dell, L. E., Purdy, R. H., Covey, D. F., Richardson, H. F., Roberto, M., Koob, G. F. Epipregnanolone and a novel synthetic neuroactive steroid reduce alcohol self-administration in rats Pharmacology, Biochemistry and Behavior  2005 81:543-550  DOI:10.1016/j.pbb.2005.03.020  PMID:15950269
    • Ahmed, S. H., Koob, G. F. Transition to drug addiction: A negative reinforcement model based on an allostatic decrease in reward function Psychopharmacology  2005 180:473-490  DOI:10.1007/s00213-005-2180-z  PMID:15731896
    • Zorrilla, E. P., Inoue, K., Fekete, E. M., Tabarin, A., Valdez, G. R., Koob, G. F. Measuring meals: Structure of prandial food and water intake of rats American Journal of Physiology-Regulatory Integrative and Comparative Physiology  2005 288:R1450-R1467  DOI:10.1152/ajpregu.00175.2004  PMID:15637168
    • Kenny, P. J., Boutrel, B., Gasparini, F., Koob, G. F., Markou, A. Metabotropic glutamate 5 receptor blockade may attenuate cocaine self-administration by decreasing brain reward function in rats Psychopharmacology  2005 179:247-254  DOI:10.1007/s00213-004-2069-2  PMID:15602687
    • Breese, G. R., Chu, K., Dayas, C. V., Funk, D., Knapp, D. J., Koob, G. F., Le, D. A., O'Dell, L. E., Overstreet, D. H., Roberts, A. J., Sinha, R., Valdez, G. R., et al. Stress enhancement of craving during sobriety: A risk for relapse Alcoholism-Clinical and Experimental Research  2005 29:185-195  DOI:10.1097/01.alc.0000153544.83656.3c  PMID:15714042
    • Stinus, L., Cador, M., Zorrilla, E. P., Koob, G. F. Buprenorphine and a crf1 antagonist block the acquisition of opiate withdrawal-induced conditioned place aversion in rats Neuropsychopharmacology  2005 30:90-98  DOI:10.1038/sj.npp.1300487  PMID:151384
    • Zorrilla, E. P., Inoue, K., Valdez, G. R., Tabarin, A., Koob, G. F. Leptin and post-prandial satiety: Acute central leptin more potently reduces meal frequency than meal size in the rat Psychopharmacology  2005 177:324-335  DOI:10.1007/s00213-004-1952-1  PMID:15609069
    • De Witte, P., Littleton, J., Parot, P., Koob, G. Neuroprotective and abstinence-promoting effects of acamprosate - elucidating the mechanism of action CNS Drugs  2005 19:517-537  DOI:10.2165/00023210-200519060-00004  PMID:15963001
    • Valdez, G. R., Koob, G. F. Allostasis and dysregulation of corticotropin-releasing factor and neuropeptide y systems: Implications for the development of alcoholism Pharmacology, Biochemistry and Behavior  2004 79:671-689  DOI:10.1016/j.pbb.2004.09.020  PMID:15582675
    • Heinrichs, S. C., Koob, G. F. Corticotropin-releasing factor in brain: A role in activation, arousal, and affect regulation Journal of Pharmacology and Experimental Therapeutics  2004 311:427-440  DOI:10.1124/jpet.103.052092  PMID:15297468
    • O'Dell, L. E., Roberts, A. J., Smith, R. T., Koob, G. F. Enhanced alcohol self-administration after intermittent versus continuous alcohol vapor exposure Alcoholism-Clinical and Experimental Research  2004 28:1676-1682  DOI:10.1097/01.alc.0000145781.11923.4e  PMID:15547454
    • Koob, G. F. A role for gaba mechanisms in the motivational effects of alcohol Biochemical Pharmacology  2004 68:1515-1525  DOI:10.1016/j.bcp.2004.07.031  PMID:15451394
    • Navarro, M., Carrera, M. R. A., del Arco, I., Trigo, J. M., Koob, G. F., de Fonseca, F. R. Cannabinoid receptor antagonist reduces heroin self-administration only in dependent rats European Journal of Pharmacology  2004 501:235-237  DOI:10.1016/j.ejphar.2004.08.022  PMID:15464083
    • Martin, G., Guadano-Ferraz, A., Morte, B., Ahmed, S., Koob, G. F., de Lecea, L., Siggins, G. R. Chronic morphine treatment alters n-methyl-d-aspartate receptors in freshly isolated neurons from nucleus accumbens Journal of Pharmacology and Experimental Therapeutics  2004 311:265-273  DOI:10.1124/jpet.104.067504  PMID:15263066
    • Zorrilla, E. P., Reinhardt, L. E., Valdez, G. R., Inoue, K., Rivier, J. E., Vale, W. W., Koob, G. F. Human urocortin 2, a corticotropin-releasing factor (crf)(2) agonist, and ovine crf, a crf1 agonist, differentially alter feeding and motor activity Journal of Pharmacology and Experimental Therapeutics  2004 310:1027-1034  DOI:10.1124/jpet.104.068676  PMID:15115804
    • Carrera, M. R. A., Kaufmann, G. F., Mee, J. M., Meijler, M. M., Koob, G. F., Janda, K. D. Treating cocaine addiction with viruses Proceedings of the National Academy of Sciences of the United States of America  2004 101:10416-10421  DOI:10.1073/pnas.0403795101  PMID:15226496  PMCID:PMC478586
    • Zorrilla, E. P., Koob, G. F. The therapeutic potential of crf1 antagonists for anxiety Expert Opinion on Investigational Drugs  2004 13:799-828  DOI:10.1517/13543784.13.7.799  PMID:15212620
    • Valdez, G. R., Sabino, V., Koob, G. F. Increased anxiety-like behavior and ethanol self-administration in dependent rats: Reversal via corticotropin-releasing factor-2 receptor activation Alcoholism-Clinical and Experimental Research  2004 28:865-872  DOI:10.1097/01.alc.0000128222.29875.40  PMID:15201629
    • Inoue, K., Zorrilla, E. P., Tabarin, A., Valdez, G. R., Iwasaki, S., Kiriike, N., Koob, G. F. Reduction of anxiety after restricted feeding in the rat: Implication for eating disorders Biological Psychiatry  2004 55:1075-1081  DOI:10.1016/j.biopsych.2004.01.026  PMID:15158426
    • Azar, M. R., Ahmed, S. H., Lintz, R., Gutierrez, T., Stinus, L., Koob, G. F. A non-invasive gating device for continuous drug delivery that allows control over the timing and duration of spontaneous opiate withdrawal Journal of Neuroscience Methods  2004 135:129-135  DOI:10.1016/j.neumeth.2003.12.008  PMID:15020097
    • Ahmed, S. H., Koob, G. F. Changes in response to a dopamine receptor antagonist in rats with escalating cocaine intake Psychopharmacology  2004 172:450-454  DOI:10.1007/s00213-003-1682-9  PMID:14647962
    • Solbrig, M. V., Koob, G. F. Epilepsy, cns viral injury and dynorphin Trends in Pharmacological Sciences  2004 25:98-104  DOI:10.1016/j.tips.2003.12.010  PMID:15102496
    • Carrera, M. R. A., Ashley, J. A., Hoffman, T. Z., Isomura, S., Wirsching, P., Koob, G. F., Janda, K. D. Investigations using immunization to attenuate the psychoactive effects of nicotine Bioorganic & Medicinal Chemistry  2004 12:563-570  DOI:10.1016/j.bmc.2003.11.029  PMID:14738965
    • O'Dell, L. E., Alomary, A. A., Vallee, M., Koob, G. F., Fitzgerald, R. L., Purdy, R. H. Ethanol-induced increases in neuroactive steroids in the rat brain and plasma are absent in adrenalectomized and gonadectomized rats European Journal of Pharmacology  2004 484:241-247  DOI:10.1016/j.ejphar.2003.11.031  PMID:14744609
    • Ben-Shahar, O., Ahmed, S. H., Koob, G. F., Ettenberg, A. The transition from controlled to compulsive drug use is associated with a loss of sensitization Brain Research  2004 995:46-54  DOI:10.1016/j.brainres.2003.09.053  PMID:14644470
    • Weed, M. R., Gold, L. H., Polis, I., Koob, G. F., Fox, H. S., Taffe, M. A. Impaired performance on a rhesus monkey neuropsychological testing battery following simian immunodeficiency virus infection AIDS Research and Human Retroviruses  2004 20:77-89  DOI:10.1089/088922204322749521  PMID:15000701
    • Koob, G. F., Ahmed, S. H., Boutrel, B., Chen, S. A., Kenny, P. J., Markou, A., O'Dell, L. E., Parsons, L. H., Sanna, P. P. Neurobiological mechanisms in the transition from drug use to drug dependence Neuroscience and Biobehavioral Reviews  2004 27:739-749  DOI:10.1016/j.neubiorev.2003.11.007  PMID:15019424
    • Boutrel, B., Koob, G. F. What keeps us awake: The neuropharmacology of stimulants and wakefulness promoting medications Sleep  2004 27:1181-1194  PMID:15532213
    • Koob, G. F. Neuroadaptive mechanisms of addiction: Studies on the extended amygdala European Neuropsychopharmacology  2003 13:442-452  DOI:10.1016/j.euroneuro.2003.08.005  PMID:14636
    • Kenny, P. J., Koob, G. F., Markou, A. Conditioned facilitation of brain reward function after repeated cocaine administration Behavioral Neuroscience  2003 117:1103-1107  DOI:10.1037/0735-7044.117.5.1103  PMID:14570559
    • Valdez, G. R., Zorrilla, E. P., Rivier, J., Vale, W. W., Koob, G. F. Locornotor suppressive and anxiolytic-like effects of urocortin 3, a highly selective type 2 corticotropin-releasing factor agonist Brain Research  2003 980:206-212  DOI:10.1016/s0006-8993(03)02971-8  PMID:12867260
    • Heyser, C. J., Moc, K., Koob, G. F. Effects of naltrexone alone and in combination with acamprosate on the alcohol deprivation effect in rats Neuropsychopharmacology  2003 28:1463-1471  DOI:10.1038/sj.npp.1300175  PMID:1270
    • Zorrilla, E. P., Tache, Y., Koob, G. F. Nibbling at crf receptor control of feeding and gastrocolonic motility Trends in Pharmacological Sciences  2003 24:421-427  DOI:10.1016/s0165-6147(03)00177-9  PMID:12915052
    • Ahmed, S. H., Lin, D., Koob, G. F., Parsons, L. H. Escalation of cocaine self-administration does not depend on altered cocaine-induced nucleus accumbens dopamine levels Journal of Neurochemistry  2003 86:102-113  DOI:10.1046/j.1471-4159.2003.01833.x  PMID:12807430
    • Vallee, M., Purdy, R. H., Mayo, W., Koob, G. F., Le Moal, M. Neuroactive steroids: New biomarkers of cognitive aging Journal of Steroid Biochemistry and Molecular Biology  2003 85:329-335  DOI:10.1016/s0960-0760(03)00227-9  PMID:12943719
    • Walker, J. R., Chen, S. A., Moffitt, H., Inturrisi, C. E., Koob, G. F. Chronic opioid exposure produces increased heroin self-administration in rats Pharmacology, Biochemistry and Behavior  2003 75:349-354  DOI:10.1016/s0091-3057(03)00094-7  PMID:12873626
    • Inoue, K., Valdez, G. R., Reyes, T. M., Reinhardt, L. E., Tabarin, A., Rivier, J., Vale, W. W., Sawchenko, P. E., Koob, G. F., Zorrilla, E. P. Human urocortin ii, a selective agonist for the type 2 corticotropin-releasing factor receptor, decreases feeding and drinking in the rat Journal of Pharmacology and Experimental Therapeutics  2003 305:385-393  DOI:10.1124/jpet.102.047712  PMID:12649393
    • Solbrig, M. V., Koob, G. F. Neuropharmacological sequelae of persistent cns viral infections: Lessons from borna disease virus Pharmacology, Biochemistry and Behavior  2003 74:777-787  DOI:10.1016/s0091-3057(03)00019-4  PMID:12667891
    • Koob, G. F. Alcoholism: Allostasis and beyond Alcoholism-Clinical and Experimental Research  2003 27:232-243  DOI:10.1097/01.alc.0000057122.36127.c2  PMID:12605072
    • Valdez, G. R., Zorrilla, E. P., Roberts, A. J., Koob, G. F. Antagonism of corticotropin-releasing factor attenuates the enhanced responsiveness to stress observed during protracted ethanol abstinence Alcohol  2003 29:55-60  DOI:10.1016/s0741-8329(03)00020-x  PMID:12782246
    • Caille, S., Stinus, L., Espejo, E. F., De Deurwaerdere, P., Spampinato, U., Koob, G. F. Inhibition of 5-ht neurotransmission increases clonidine protective effects on naloxone-induced conditioned place aversion in morphine-dependent rats Neuropsychopharmacology  2003 28:276-283  DOI:10.1038/sj.npp.1300033  PMID:125893
    • Alomary, A. A., Vallee, M., O'Dell, L. E., Koob, G. F., Purdy, R. H., Fitzgerald, R. L. Acutely administered ethanol participates in testosterone synthesis and increases testosterone in rat brain Alcoholism-Clinical and Experimental Research  2003 27:38-43  DOI:10.1097/01.alc.0000047304.28550.4f  PMID:12544003
    • Koob, G. F., Roberts, A. J., Kieffer, B. L., Heyser, C. J., Katner, S. N., Ciccocioppo, R., Weiss, F. Animal models of motivation for drinking in rodents with a focus on opioid receptor neuropharmacology Recent Developments in Alcoholism  2003 16:263-281  DOI:10.1007/0-306-47939-7_19  PMID:12638642
    • Kenny, P. J., Polis, I., Koob, G. F., Markou, A. Low dose cocaine self-administration transiently increases but high dose cocaine persistently decreases brain reward function in rats European Journal of Neuroscience  2003 17:191-195  DOI:10.1046/j.1460-9568.2003.02443.x  PMID:12534985
    • Izzo, E., Martin-Fardon, R., Koob, G. F., Weiss, F., Sanna, P. P. Neural plasticity and addiction: PI3-kinase and cocaine behavioral sensitization Nature Neuroscience  2002 5:1263-1264  DOI:10.1038/nn977  PMID:12436114
    • Solbrig, M. V., Koob, G. F., Lipkin, W. I. Key role for enkephalinergic tone in cortico-striatal-thalamic function European Journal of Neuroscience  2002 16:1819-1822  DOI:10.1046/j.1460-9568.2002.02240.x  PMID:12431235
    • Zorrilla, E. P., Valdez, G. R., Nozulak, J., Koob, G. F., Markou, A. Effects of antalarmin, a crf type 1 receptor antagonist, on anxiety-like behavior and motor activation in the rat Brain Research  2002 952:188-199  DOI:10.1016/s0006-8993(02)03189-x  PMID:12376179
    • Zorrilla, E. P., Schulteis, G., Ormsby, A., Klaassen, A., Ling, N., McCarthy, J. R., Koob, G. F., De Souza, E. B. Urocortin shares the memory modulating effects of corticotropin-releasing factor (crf): Mediation by crf1 receptors Brain Research  2002 952:200-210  DOI:10.1016/s0006-8993(02)03345-0  PMID:12376180
    • Valdez, G. R., Roberts, A. J., Chan, K., Davis, H., Brennan, M., Zorrilla, E. P., Koob, G. F. Increased ethanol self-administration and anxiety-like behavior during acute ethanol withdrawal and protracted abstinence: Regulation by corticotropin-releasing factor Alcoholism-Clinical and Experimental Research  2002 26:1494-1501  DOI:10.1097/01.alc.0000033120.51856.f0  PMID:12394282
    • Sanna, P. P., Simpson, C., Lutjens, R., Koob, G. ERK regulation in chronic ethanol exposure and withdrawal Brain Research  2002 948:186-191  DOI:10.1016/s0006-8993(02)03191-8  PMID:12383974
    • Walker, J. R., Terenius, L., Koob, G. F. Conditioned opioid withdrawal decreases nociceptin/orphanin cortex and olfactory fq levels in the frontal cortex and olfactory tubercle Neuropsychopharmacology  2002 27:203-211  DOI:10.1016/s0893-133x(02)00292-0  PMID:12093
    • Vetter, D. E., Li, C. E., Zhao, L. Y., Contarino, A., Liberman, M. C., Smith, G. W., Marchuk, Y., Koob, G. F., Heinemann, S. F., Vale, W., Lee, K. F. Urocortin-deficient mice show hearing impairment and increased anxiety-like behavior Nature Genetics  2002 31:363-369  DOI:10.1038/ng914  PMID:12091910
    • Valdez, G. R., Inoue, K., Koob, G. F., Rivier, J., Vale, W., Zorrilla, E. P. Human urocortin ii: Mild locomotor suppressive and delayed anxiolytic-like effects of a novel corticotropin-releasing factor related peptide Brain Research  2002 943:142-150  DOI:10.1016/s0006-8993(02)02707-5  PMID:12088848
    • Caille, S., Espejo, E. F., Koob, G. F., Stinus, L. Dorsal and median raphe serotonergic system lesion does not alter the opiate withdrawal syndrome Pharmacology, Biochemistry and Behavior  2002 72:979-986  DOI:10.1016/s0091-3057(02)00810-9  PMID:12062589
    • Contarino, A., Picetti, R., Matthes, H. W., Koob, G. F., Kieffer, B. L., Gold, L. H. Lack of reward and locomotor stimulation induced by heroin in mu-opioid receptor-deficient mice European Journal of Pharmacology  2002 446:103-109  DOI:10.1016/s0014-2999(02)01812-5  PMID:12098591
    • Smith, A. D., Amalric, M., Koob, G. F., Zigmond, M. J. Effect of bilateral 6-hydroxydopamine lesions of the medial forebrain bundle on reaction time Neuropsychopharmacology  2002 26:756-764  DOI:10.1016/s0893-133x(01)00420-1  PMID:12007
    • Ryabinin, A. E., Bachtell, R. K., Heinrichs, S. C., Lee, S., Rivier, C., Olive, M. F., Mehmert, K. K., Camarini, R., Kim, J. A., Koenig, H. N., Nannini, M. A., Hodge, C. W., et al. The corticotropin-releasing factor/urocortin system and alcohol Alcoholism-Clinical and Experimental Research  2002 26:714-722  DOI:10.1111/j.1530-0277.2002.tb02596.x  PMID:12045481
    • Pulvirenti, L., Koob, G. F. Being partial to psychostimulant addiction therapy Trends in Pharmacological Sciences  2002 23:151-153  DOI:10.1016/s0165-6147(00)01991-x  PMID:11931978
    • Hungund, B. L., Basavarajappa, B. S., Vadasz, C., Kunos, G., de Fonseca, F. R., Colombo, G., Serra, S., Parsons, L., Koob, G. F. Ethanol, endocannabinoids, and the cannabinoidergic signaling system Alcoholism-Clinical and Experimental Research  2002 26:565-574  DOI:10.1111/j.1530-0277.2002.tb02575.x  PMID:11981134
    • Koob, G. F., Mason, B. J., De Witte, P., Littleton, J., Siggins, G. R. Potential neuroprotective effects of acamprosate Alcoholism-Clinical and Experimental Research  2002 26:586-592  DOI:10.1111/j.1530-0277.2002.tb02578.x  PMID:11981137
    • Spina, M. G., Merlo-Pich, E., Akwa, Y., Balducci, C., Basso, A. M., Zorrilla, E. P., Britton, K. T., Rivier, J., Vale, W. W., Koob, G. F. Time-dependent induction of anxiogenic-like effects after central infusion of urocortin or corticotropin-releasing factor in the rat Psychopharmacology  2002 160:113-121  DOI:10.1007/s00213-001-0940-y  PMID:11875628
    • Orsini, C., Izzo, E., Koob, G. F., Pulvirenti, L. Blockade of nitric oxide synthesis reduces responding for cocaine self-administration during extinction and reinstatement Brain Research  2002 925:133-140  DOI:10.1016/s0006-8993(01)03267-x  PMID:11792361
    • Bale, T. L., Picetti, R., Contarino, A., Koob, G. F., Vale, W. W., Lee, K. F. Mice deficient for both corticotropin-releasing factor receptor 1 (crfr1) and crfr2 have an impaired stress response and display sexually dichotomous anxiety-like behavior Journal of Neuroscience  2002 22:193-199  PMID:11756502
    • Ahmed, S. H., Kenny, P. J., Koob, G. F., Markou, A. Neurobiological evidence for hedonic allostasis associated with escalating cocaine use Nature Neuroscience  2002 5:625-626  DOI:10.1038/nn872  PMID:12055635
    • Vallee, M., Shen, W., Heinrichs, S. C., Zorumski, C. F., Covey, D. F., Koob, G. F., Purdy, R. H. Steroid structure and pharmacological properties determine the anti-amnesic effects of pregnenolone sulphate in the passive avoidance task in rats European Journal of Neuroscience  2001 14:2003-2010  DOI:10.1046/j.0953-816x.2001.01817.x  PMID:11860495
    • Orsini, C., Koob, G. F., Pulvirenti, L. Dopamine partial agonist reverses amphetamine withdrawal in rats Neuropsychopharmacology  2001 25:789-792  DOI:10.1016/s0893-133x(01)00270-6  PMID:11682
    • Currie, P. J., Coscina, D. V., Bishop, C., Coiro, C. D., Koob, G. F., Rivier, J., Vale, W. Hypothalamic paraventricular nucleus injections of urocortin alter food intake and respiratory quotient Brain Research  2001 916:222-228  DOI:10.1016/s0006-8993(01)02851-7  PMID:11597609
    • Roberts, A. J., Gold, L. H., Polis, L., McDonald, J. S., Filliol, D., Kieffer, B. L., Koob, G. F. Increased ethanol self-administration in delta-opioid receptor knockout mice Alcoholism-Clinical and Experimental Research  2001 25:1249-1256  DOI:10.1111/j.1530-0277.2001.tb02344.x  PMID:11584142
    • Navarro, M., Carrera, M. R. A., Fratta, W., Valverde, O., Cossu, G., Fattore, L., Chowen, J. A., Gomez, R., del Arco, I., Villanua, M. A., Maldonado, R., Koob, G. F., et al. Functional interaction between opioid and cannabinoid receptors in drug self-administration Journal of Neuroscience  2001 21:5344-5350  PMID:11438610
    • Zorrilla, E. P., Schulteis, G., Ling, N., Koob, G. F., De Souza, E. B. Performance-enhancing effects of crf-bp ligand inhibitors Neuroreport  2001 12:1231-1234  DOI:10.1097/00001756-200105080-00035  PMID:11338197
    • Le, A. D., Kiianmaa, K., Cunningham, C. L., Engel, J. A., Ericson, M., Soderpalm, B., Koob, G. F., Roberts, A. J., Weiss, F., Hyytia, P., Janhunen, S., Mikkola, J., et al. Neurobiological processes in alcohol addiction Alcoholism-Clinical and Experimental Research  2001 25:144S-151S  DOI:10.1111/j.1530-0277.2001.tb02389.x  PMID:11391064
    • Izzo, E., Orsini, C., Koob, G. F., Pulvirenti, L. A dopamine partial agonist and antagonist block amphetamine self-administration in a progressive ratio schedule Pharmacology, Biochemistry and Behavior  2001 68:701-708  DOI:10.1016/s0091-3057(01)00472-5  PMID:11526967
    • Macey, D. J., Froestl, W., Koob, G. F., Markou, A. Both gaba(b) receptor agonist and antagonists decreased brain stimulation reward in the rat Neuropharmacology  2001 40:676-685  DOI:10.1016/s0028-3908(00)00204-5  PMID:11311895
    • David, V., Gold, L. H., Koob, G. F., Cazala, P. Anxiogenic-like effects limit rewarding effects of cocaine in balb/cbyj mice Neuropsychopharmacology  2001 24:300-318  DOI:10.1016/s0893-133x(00)00205-0  PMID:11166
    • Carrera, M. R. A., Ashley, J. A., Wirsching, P., Koob, G. F., Janda, K. D. A second-generation vaccine protects against the psychoactive effects of cocaine Proceedings of the National Academy of Sciences of the United States of America  2001 98:1988-1992  DOI:10.1073/pnas.041610998  PMID:11172063
    • Koob, G. F., Le Moal, M. Drug addiction, dysregulation of reward, and allostasis Neuropsychopharmacology  2001 24:97-129  DOI:10.1016/s0893-133x(00)00195-0  PMID:111203
    • Gracy, K. N., Dankiewicz, L. A., Koob, G. F. Opiate withdrawal-induced fos immunoreactivity in the rat extended amygdala parallels the development of conditioned place aversion Neuropsychopharmacology  2001 24:152-160  DOI:10.1016/s0893-133x(00)00186-x  PMID:11120
    • Weiss, F., Koob, G. F. Drug addiction: Functional neurotoxicity of the brain reward systems Neurotoxicity Research  2001 3:145-156  DOI:10.1007/bf03033235  PMID:15111266
    • Koob, G., Bartfai, T., Roberts, A. J. Molecular genetic approaches to the neuropharmacology of corticotropin releasing factor International Journal of Comparative Psychology  2001 14:90-110
    • Vallee, M., Mayo, W., Koob, G. F., Le Moal, M. Neurosteroids in learning and memory processes Neurosteroids and Brain Function  2001 46:273-320  PMID:11599303
    • Richter, R. M., Zorrilla, E. P., Basso, A. M., Koob, G. F., Weiss, F. Altered amygdalar crf release and increased anxiety-like behavior in sardinian alcohol-preferring rats: A microdialysis and behavioral study Alcoholism-Clinical and Experimental Research  2000 24:1765-1772  DOI:10.1111/j.1530-0277.2000.tb01979.x  PMID:11141034
    • Vallee, M., Rivera, J. D., Koob, G. F., Purdy, R. H., Fitzgerald, R. L. Quantification of neurosteroids in rat plasma and brain following swim stress and allopregnanolone administration using negative chemical ionization gas chromatography/mass spectrometry Analytical Biochemistry  2000 287:153-166  DOI:10.1006/abio.2000.4841  PMID:11078595
    • Solbrig, M. V., Koob, G. F., Parsons, L. H., Kadota, T., Horscroft, N., Briese, T., Lipkin, W. I. Neurotrophic factor expression after CNS viral injury produces enhanced sensitivity to psychostimulants: potential mechanism for addiction vulnerability Journal of Neuroscience  2000 20:RC104  PMID:11050146
    • Koob, G. Drug addiction Neurobiology of Disease  2000 7:543-545  DOI:10.1006/nbdi.2000.0351  PMID:11042073
    • Koob, G. F. Animal models of craving for ethanol Addiction  2000 95:73-81  DOI:10.1046/j.1360-0443.95.8s2.17.x  PMID:11002904
    • Morse, A. C., Schulteis, G., Holloway, F. A., Koob, G. F. Conditioned place aversion to the "hangover" phase of acute ethanol administration in the rat Alcohol  2000 22:19-24  DOI:10.1016/s0741-8329(00)00099-9  PMID:11109024
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    • Roberts, A. J., Heyser, C. J., Cole, M., Griffin, P., Koob, G. F. Excessive ethanol drinking following a history of dependence: Animal model of allostasis Neuropsychopharmacology  2000 22:581-594  DOI:10.1016/s0893-133x(99)00167-0  PMID:10788
    • Roberts, A. J., McDonald, J. S., Heyser, C. J., Kieffer, B. L., Matthes, H. W. D., Koob, G. F., Gold, L. H. Mu-opioid receptor knockout mice do not self-administer alcohol Journal of Pharmacology and Experimental Therapeutics  2000 293:1002-1008  PMID:10869404
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    • Bale, T. L., Contarino, A. B., Smith, G. W., Chan, R., Gold, L. H., Sawchenko, P. E., Koob, G. F., Vale, W. W., Lee, K. F. Mice deficient for corticotropin-releasing hormone receptor-2 display anxiety-like behaviour and are hypersensitive to stress Nature Genetics  2000 24:410-414  PMID:10742108
    • Stinus, L., Caille, S., Koob, G. F. Opiate withdrawal-induced place aversion lasts for up to 16 weeks Psychopharmacology  2000 149:115-120  DOI:10.1007/s002139900358  PMID:10805605
    • Ahmed, S. H., Walker, J. R., Koob, G. F. Persistent increase in the motivation to take heroin in rats with a history of drug escalation Neuropsychopharmacology  2000 22:413-421  DOI:10.1016/s0893-133x(99)00133-5  PMID:107006
    • Spina, M. G., Basso, A. M., Zorrilla, E. P., Heyser, C. J., Rivier, J., Vale, W., Merlo-Pich, E., Koob, G. F. Behavioral effects of central administration of the novel crf antagonist astressin in rats Neuropsychopharmacology  2000 22:230-239  DOI:10.1016/s0893-133x(99)00108-6  PMID:10693
    • Smith, A. D., Smith, D. L., Zigmond, M. J., Amalric, M., Koob, G. F. Differential effects of dopamine receptor subtype blockade on performance of rats in a reaction-time paradigm Psychopharmacology  2000 148:355-360  DOI:10.1007/s002130050063  PMID:10928307
    • Gracy, K. N., Dankiewicz, L. A., Weiss, F., Koob, G. F. Heroin-specific stimuli reinstate operant heroin-seeking behavior in rats after prolonged extinction Pharmacology, Biochemistry and Behavior  2000 65:489-494  DOI:10.1016/s0091-3057(99)00234-8  PMID:10683489
    • Watkins, S. S., Stinus, L., Koob, G. F., Markou, A. Reward and somatic changes during precipitated nicotine withdrawal in rats: Centrally and peripherally mediated effects Journal of Pharmacology and Experimental Therapeutics  2000 292:1053-1064  PMID:10688623
    • Lin, D., Koob, G. F., Markou, A. Time-dependent alterations in icss thresholds associated with repeated amphetamine administrations Pharmacology, Biochemistry and Behavior  2000 65:407-417  DOI:10.1016/s0091-3057(99)00213-0  PMID:10683480
    • Walker, J. R., Ahmed, S. H., Gracy, K. N., Koob, G. F. Microinjections of an opiate receptor antagonist into the bed nucleus of the stria terminalis suppress heroin self-administration in dependent rats Brain Research  2000 854:85-92  DOI:10.1016/s0006-8993(99)02288-x  PMID:10784110
    • Dellu, F., Contarino, A., Simon, H., Koob, G. F., Gold, L. H. Genetic differences in response to novelty and spatial memory using a two-trial recognition task in mice Neurobiology of Learning and Memory  2000 73:31-48  DOI:10.1006/nlme.1999.3919  PMID:10686122
    • Britton, K. T., Akwa, Y., Spina, M. G., Koob, G. F. Neuropeptide y blocks anxiogenic-like behavioral action of corticotropin-releasing factor in an operant conflict test and elevated plus maze Peptides  2000 21:37-44  DOI:10.1016/s0196-9781(99)00169-2  PMID:10704717
    • Baldo, B. A., Koob, G. F., Markou, A. Role of adenosine a2 receptors in brain stimulation reward under baseline conditions and during cocaine withdrawal in rats Journal of Neuroscience  1999 19:11017-11026  PMID:10594082
    • Roberts, A., Heyser, C., Koob, G. Blood alcohol concentrations in rats drinking or intubated with ethanol. Response Alcoholism-Clinical and Experimental Research  1999 23:1946-1947  DOI:10.1111/j.1530-0277.1999.tb04098.x  PMID:10630615
    • Akwa, Y., Purdy, R. H., Koob, G. F., Britton, K. T. The amygdala mediates the anxiolytic-like effect of the neurosteroid allopregnanolone in rat Behavioural Brain Research  1999 106:119-125  DOI:10.1016/s0166-4328(99)00101-1  PMID:10595427
    • Koob, G. F. Corticotropin-releasing factor, norepinephrine, and stress Biological Psychiatry  1999 46:1167-1180  DOI:10.1016/s0006-3223(99)00164-x  PMID:10560023
    • Walker, J. R., King, M., Izzo, E., Koob, G. F., Pasternak, G. W. Antagonism of heroin and morphine self-administration in rats by the morphine-6 beta-glucuronide antagonist 3-o-methylnaltrexone European Journal of Pharmacology  1999 383:115-119  DOI:10.1016/s0014-2999(99)00633-0  PMID:10585524
    • Weed, M. R., Taffe, M. A., Polis, I., Roberts, A. C., Robbins, T. W., Koob, G. F., Bloom, F. E., Gold, L. H. Performance norms for a rhesus monkey neuropsychological testing battery: acquisition and long-term performance Cognitive Brain Research  1999 8:185-201  DOI:10.1016/s0926-6410(99)00020-8  PMID:10556598
    • Martin, G., Ahmed, S. H., Blank, T., Spiess, J., Koob, G. F., Siggins, G. R. Chronic morphine treatment alters nmda receptor-mediated synaptic transmission in the nucleus accumbens Journal of Neuroscience  1999 19:9081-9089  PMID:10516325
    • Ahmed, S. H., Koob, G. F. Long-lasting increase in the set point for cocaine self-administration after escalation in rats Psychopharmacology  1999 146:303-312  DOI:10.1007/s002130051121  PMID:10541731
    • Heyser, C. J., Roberts, A. J., Schulteis, G., Koob, G. F. Central administration of an opiate antagonist decreases oral ethanol self-administration in rats Alcoholism-Clinical and Experimental Research  1999 23:1468-1476  DOI:10.1097/00000374-199909000-00008  PMID:10512312
    • Lin, D., Koob, G. F., Markou, A. Differential effects of withdrawal from chronic amphetamine or fluoxetine administration on brain stimulation reward in the rat - interactions between the two drugs Psychopharmacology  1999 145:283-294  DOI:10.1007/s002130051060  PMID:10494577
    • Caille, S., Espejo, E. F., Reneric, J. P., Cador, M., Koob, G. F., Stinus, L. Total neurochemical lesion of noradrenergic neurons of the locus ceruleus does not alter either naloxone-precipitated or spontaneous opiate withdrawal nor does it influence ability of clonidine to reverse opiate withdrawal Journal of Pharmacology and Experimental Therapeutics  1999 290:881-892  PMID:10411605
    • Contarino, A., Dellu, F., Koob, G. F., Smith, G. W., Lee, K. F., Vale, W., Gold, L. H. Reduced anxiety-like and cognitive performance in mice lacking the corticotropin-releasing factor receptor 1 Brain Research  1999 835:1-9  DOI:10.1016/s0006-8993(98)01158-5  PMID:10448190
    • Lee, R. S., Criado, J. R., Koob, G. F., Henriksen, S. J. Cellular responses of nucleus accumbens neurons to opiate-seeking behavior: I. Sustained responding during heroin self-administration Synapse  1999 33:49-58  DOI:10.1002/(sici)1098-2396(199907)33:1<49::aid-syn5>3.0.co;2-o  PMID:10380850
    • Basso, A. M., Spina, M., Rivier, J., Vale, W., Koob, G. F. Corticotropin-releasing factor antagonist attenuates the "anxiogenic-like" effect in the defensive burying paradigm but not in the elevated plus-maze following chronic cocaine in rats Psychopharmacology  1999 145:21-30  DOI:10.1007/s002130051028  PMID:10445369
    • Roberts, A. J., Heyser, C. J., Koob, G. F. Operant self-administration of sweetened versus unsweetened ethanol: effects on blood alcohol levels Alcoholism-Clinical and Experimental Research  1999 23:1151-1157  DOI:10.1097/00000374-199907000-00003  PMID:10443980
    • Criado, J. R., Li, H. T., Jiang, X. H., Spina, M., Huitron-Resendiz, S., Liapakis, G., Calbet, M., Siehler, S., Henriksen, S. J., Koob, G., Hoyer, D., Sutcliffe, J. G., et al. Structural and compositional determinants of cortistatin activity Journal of Neuroscience Research  1999 56:611-619  DOI:10.1002/(sici)1097-4547(19990615)56:6<611::aid-jnr7>3.0.co;2-g  PMID:10374816
    • Schulteis, G., Heyser, C. J., Koob, G. F. Differential expression of response-disruptive and somatic indices of opiate withdrawal during the initiation and development of opiate dependence Behavioural Pharmacology  1999 10:235-242  PMID:10780239
    • Carrera, M. R. A., Schulteis, G., Koob, G. F. Heroin self-administration in dependent wistar rats: Increased sensitivity to naloxone Psychopharmacology  1999 144:111-120  DOI:10.1007/s002130050983  PMID:10394991
    • Parsons, L. H., Koob, G. F., Weiss, F. RU 24969, a 5-HT1B/1A receptor agonist, potentiates cocaine-induced increases in nucleus accumbens dopamine Synapse  1999 32:132-135  DOI:10.1002/(sici)1098-2396(199905)32:2<132::aid-syn6>3.0.co;2-v  PMID:10231132
    • Baldo, B. A., Jain, K., Veraldi, L., Koob, G. F., Markou, A. A dopamine d-1 agonist elevates self-stimulation thresholds: Comparison to other dopamine-selective drugs Pharmacology, Biochemistry and Behavior  1999 62:659-672  DOI:10.1016/s0091-3057(98)00206-8  PMID:10208371
    • Watkins, S. S., Epping-Jordan, M. P., Koob, G. F., Markou, A. Blockade of nicotine self-administration with nicotinic antagonists in rats Pharmacology, Biochemistry and Behavior  1999 62:743-751  DOI:10.1016/s0091-3057(98)00226-3  PMID:10208381
    • Leshner, A. I., Koob, G. F. Drugs of abuse and the brain Proceedings of the Association of American Physicians  1999 111:99-108  DOI:10.1046/j.1525-1381.1999.09218.x  PMID:10220804
    • Koob, G. F., Heinrichs, S. C. A role for corticotropin releasing factor and urocortin in behavioral responses to stressors Brain Research  1999 848:141-152  DOI:10.1016/s0006-8993(99)01991-5  PMID:10612706
    • Koob, G. F., Weiss, F., Tiffany, S. T., Zieglgansberger, W., Spanagel, R. Animal models of craving: a roundtable discussion Alcohol Research and Health  1999 23:233-236  PMID:10890819
    • Koob, G. F., Roberts, A. J. Brain reward circuits in alcoholism CNS Spectrums  1999 4:23-37
    • Rodrigquez De Fonseca, F., Roberts, A. J., Bilbao, A., Koob, G. F., Navarro, M. Cannabinoid receptor antagonist SR141716a decreases operant ethanol self administration in rats exposed to ethanol-vapor chambers Acta Pharmacologica Sinica  1999 20:1109-1114  PMID:11189201
    • Baldo, B. A., Markou, A., Koob, G. F. Increased sensitivity to the locomotor depressant effect of a dopamine receptor antagonist during cocaine withdrawal in the rat Psychopharmacology  1999 141:135-144  DOI:10.1007/s002130050817  PMID:9952037
    • Harrison, A. A., Parsons, L. H., Koob, G. F., Markou, A. RU 24969, a 5-HT1A/1B agonist, elevates brain stimulation reward thresholds: an effect reversed by GR 127935, a 5-HT1B/1D antagonist Psychopharmacology  1999 141:242-250  DOI:10.1007/s002130050831  PMID:10027505
    • Kimes, A. S., Maldonado, R., Ambrosio, E., Koob, G. F., London, E. D. Cerebral glucose metabolism during opioid withdrawal following methylnaloxonium injection into the locus coeruleus Brain Research  1998 814:1-12  DOI:10.1016/s0006-8993(98)00813-0  PMID:9838021
    • Kosten, T. R., Markou, A., Koob, G. F. Depression and stimulant dependence - neurobiology and pharmacotherapy Journal of Nervous and Mental Disease  1998 186:737-745  DOI:10.1097/00005053-199812000-00001  PMID:9865811
    • Parsons, L. H., Weiss, F., Koob, G. F. Serotonin(1B) receptor stimulation enhances cocaine reinforcement Journal of Neuroscience  1998 18:10078-10089  PMID:9822762
    • Navarro, M., Chowen, J., Carrera, M. R. A., del Arco, I., Villanua, M. A., Martin, Y., Roberts, A. J., Koob, G. F., de Fonseca, F. R. Cb1 cannabinoid receptor antagonist-induced opiate withdrawal in morphine-dependent rats Neuroreport  1998 9:3397-3402  DOI:10.1097/00001756-199810260-00012  PMID:9855288
    • Ahmed, S. H., Koob, G. F. Transition from moderate to excessive drug intake: Change in hedonic set point Science  1998 282:298-300  DOI:10.1126/science.282.5387.298  PMID:9765157
    • Roberts, A. J., Smith, A. D., Weiss, F., Rivier, C., Koob, G. F. Estrous cycle effects on operant responding for ethanol in female rats Alcoholism-Clinical and Experimental Research  1998 22:1564-1569  DOI:10.1097/00000374-199810000-00028  PMID:9802543
    • Pulvirenti, L., Balducci, C., Piercy, M., Koob, G. F. Characterization of the effects of the partial dopamine agonist terguride on cocaine self-administration in the rat Journal of Pharmacology and Experimental Therapeutics  1998 286:1231-1238  PMID:9732383
    • Koob, G. F., Sanna, P. P., Bloom, F. E. Neuroscience of addiction Neuron  1998 21:467-476  DOI:10.1016/s0896-6273(00)80557-7  PMID:9768834
    • Eckardt, M. J., File, S. E., Gessa, G. L., Grant, K. A., Guerri, C., Hoffman, P. L., Kalant, H., Koob, G. F., Li, T. K., Tabakoff, B. Effects of moderate alcohol consumption on the central nervous system Alcoholism-Clinical and Experimental Research  1998 22:998-1040  DOI:10.1111/j.1530-0277.1998.tb03695.x  PMID:9726269
    • Lee, R. S., Koob, G. F., Henriksen, S. J. Electrophysiological responses of nucleus accumbens neurons to novelty stimuli and exploratory behavior in the awake, unrestrained rat Brain Research  1998 799:317-322  DOI:10.1016/s0006-8993(98)00477-6  PMID:9675326
    • Walker, J. R., Spina, M., Terenius, L., Koob, G. F. Nociceptin fails to affect heroin self-administration in the rat Neuroreport  1998 9:2243-2247  DOI:10.1097/00001756-199807130-00017  PMID:9694207
    • Schulteis, G., Yackey, M., Risbrough, V., Koob, G. F. Anxiogenic-like effects of spontaneous and naloxone-precipitated opiate withdrawal in the elevated plus-maze Pharmacology, Biochemistry and Behavior  1998 60:727-731  DOI:10.1016/s0091-3057(98)00034-3  PMID:9678657
    • Smith, G. W., Aubry, J. M., Dellu, F., Contarino, A., Bilezikjian, L. M., Gold, L. H., Chen, R. P., Marchuk, Y., Hauser, C., Bentley, C. A., Sawchenko, P. E., Koob, G. F., et al. Corticotropin releasing factor receptor 1-deficient mice display decreased anxiety, impaired stress response, and aberrant neuroendocrine development Neuron  1998 20:1093-1102  DOI:10.1016/s0896-6273(00)80491-2  PMID:9655498
    • Kreek, M. J., Koob, G. F. Drug dependence: Stress and dysregulation of brain reward pathways Drug and Alcohol Dependence  1998 51:23-47  DOI:10.1016/s0376-8716(98)00064-7  PMID:9716928
    • Epping-Jordan, M. P., Watkins, S. S., Koob, G. F., Markou, A. Dramatic decreases in brain reward function during nicotine withdrawal Nature  1998 393:76-79  PMID:9590692
    • Roberts, A. J., McArthur, R. A., Hull, E. E., Post, C., Koob, G. F. Effects of amperozide, 8-OH-DPAT, and FG 5974 on operant responding for ethanol Psychopharmacology  1998 137:25-32  DOI:10.1007/s002130050589  PMID:9631953
    • Raber, J., Sorg, O., Horn, T. F. W., Yu, N., Koob, G. F., Campbell, I. L., Bloom, F. E. Inflammatory cytokines: Putative regulators of neuronal and neuro-endocrine function Brain Research Reviews  1998 26:320-326  DOI:10.1016/s0165-0173(97)00041-6  PMID:9651548
    • Solbrig, M. V., Koob, G. F., Lipkin, W. I. Cocaine sensitivity in borna disease virus-infected rats Pharmacology, Biochemistry and Behavior  1998 59:1047-1052  DOI:10.1016/s0091-3057(97)00507-8  PMID:9586866
    • Heinrichs, S. C., Klaassen, A., Koob, G. F., Schulteis, G., Ahmed, S., De Souza, E. B. Corticotropin-releasing factor receptor blockade enhances conditioned aversive properties of cocaine in rats Psychopharmacology  1998 136:247-255  DOI:10.1007/s002130050563  PMID:9566810
    • Markou, A., Kosten, T. R., Koob, G. F. Neurobiological similarities in depression and drug dependence: A self-medication hypothesis Neuropsychopharmacology  1998 18:135-174  DOI:10.1016/s0893-133x(97)00113-9  PMID:94711
    • Koob, G. F., Rocio, M., Carrera, A., Gold, L. H., Heyser, C. J., Maldonado-Irizarry, C., Markou, A., Parsons, L. H., Roberts, A. J., Schulteis, G., Stinus, L., Walker, J. R., et al. Substance dependence as a compulsive behavior Journal of Psychopharmacology  1998 12:39-48  DOI:10.1177/026988119801200106  PMID:9584967
    • Epping-Jordan, M. P., Markou, A., Koob, G. F. The dopamine d-1 receptor antagonist sch 23390 injected into the dorsolateral bed nucleus of the stria terminalis decreased cocaine reinforcement in the rat Brain Research  1998 784:105-115  DOI:10.1016/s0006-8993(97)01190-6  PMID:9518570
    • Heyser, C. J., Schulteis, G., Durbin, P., Koob, G. F. Chronic acamprosate eliminates the alcohol deprivation effect while having limited effects on baseline responding for ethanol in rats Neuropsychopharmacology  1998 18:125-133  DOI:10.1016/s0893-133x(97)00130-9  PMID:94301
    • Koob, G. F., Roberts, A. J., Schulteis, G., Parsons, L. H., Heyser, C. J., Hyytia, P., Merlo-Pich, E., Weiss, F. Neurocircuitry targets in ethanol reward and dependence Alcoholism-Clinical and Experimental Research  1998 22:3-9  DOI:10.1097/00000374-199802000-00001  PMID:9514280
    • Schulteis, G., Stinus, L., Risbrough, V. B., Koob, G. F. Clonidine blocks acquisition but not expression of conditioned opiate withdrawal in rats Neuropsychopharmacology  1998 19:406-416  DOI:10.1016/s0893-133x(98)00036-0  PMID:97786
    • Heinrichs, S. C., Menzaghi, F., Koob, G. F. Neuropeptide y-induced feeding and its control Vitamins and Hormones  1998 54:51-66  PMID:9529973
    • Koob, G. F., LeMoal, M. Drug abuse: Hedonic homeostatic dysregulation Science  1997 278:52-58  DOI:10.1126/science.278.5335.52  PMID:9311926
    • Ahmed, S. H., Koob, G. F. Cocaine but not food-seeking behavior is reinstated by stress after extinction Psychopharmacology  1997 132:289-295  DOI:10.1007/s002130050347  PMID:9292629
    • Brot, M. D., Rall, G. F., Oldstone, M. B. A., Koob, G. F., Gold, L. H. Deficits in discriminated learning remain despite clearance of long-term persistent viral infection in mice Journal of Neurovirology  1997 3:265-273  PMID:9291234
    • Heyser, C. J., Schulteis, G., Koob, G. F. Increased ethanol self-administration after a period of imposed ethanol deprivation in rats trained in a limited access paradigm Alcoholism-Clinical and Experimental Research  1997 21:784-791  DOI:10.1097/00000374-199708000-00004  PMID:9267526
    • Caine, S. B., Koob, G. F., Parsons, L. H., Everitt, B. J., Schwartz, J. C., Sokoloff, P. D3 receptor test in vitro predicts decreased cocaine self-administration in rats Neuroreport  1997 8:2373-2377  DOI:10.1097/00001756-199707070-00054  PMID:9243643
    • Britton, K. T., Southerland, S., VanUden, E., Kirby, D., Rivier, J., Koob, G. Anxiolytic activity of npy receptor agonists in the conflict test Psychopharmacology  1997 132:6-13  DOI:10.1007/s002130050313  PMID:9272753
    • Deroche, V., Caine, S. B., Heyser, C. J., Polis, I., Koob, G. F., Gold, L. H. Differences in the liability to self-administer intravenous cocaine between c57bl/6xsjl and balb/cbyj mice Pharmacology, Biochemistry and Behavior  1997 57:429-440  DOI:10.1016/s0091-3057(96)00439-x  PMID:9218267
    • Koob, G. F., Caine, S. B., Parsons, L., Markou, A., Weiss, F. Opponent process model and psychostimulant addiction Pharmacology, Biochemistry and Behavior  1997 57:513-521  DOI:10.1016/s0091-3057(96)00438-8  PMID:9218276
    • Heyser, C. J., McDonald, J. S., Beauchamp, V., Koob, G. F., Gold, L. H. The effects of cocaine on operant responding for food in several strains of mice Psychopharmacology  1997 132:202-208  DOI:10.1007/s002130050337  PMID:9266618
    • deFonseca, F. R., Carrera, M. R. A., Navarro, M., Koob, G. F., Weiss, F. Activation of corticotropin-releasing factor in the limbic system during cannabinoid withdrawal Science  1997 276:2050-2054  PMID:9197270
    • Brot, M. D., Akwa, Y., Purdy, R. H., Koob, G. F., Britton, K. T. The anxiolytic-like effects of the neurosteroid allopregnanolone: Interactions with gaba(a) receptors European Journal of Pharmacology  1997 325:1-7  DOI:10.1016/s0014-2999(97)00096-4  PMID:9151931
    • Raber, J., Koob, G. F., Bloom, F. E. Interferon-alpha and transforming growth factor-beta(1) regulate corticotropin-releasing factor release from the amygdala: Comparison with the hypothalamic response Neurochemistry International  1997 30:455-463  DOI:10.1016/s0197-0186(96)00082-4  PMID:9106261
    • Pulvirenti, L., Balducci, C., Koob, G. F. Dextromethorphan reduces intravenous cocaine self-administration in the rat European Journal of Pharmacology  1997 321:279-283  DOI:10.1016/s0014-2999(96)00970-3  PMID:9085038
    • de Fonseca, F. R., Navarro, M., Carrera, M. R. A., Koob, G. F., Weiss, F. Marijuana addiction: Response Science  1997 277:751-752  DOI:10.1126/science.277.5327.749a
    • Schulteis, G., Heyser, C. J., Koob, G. F. Opiate withdrawal signs precipitated by naloxone following a single exposure to morphine: Potentiation with a second morphine exposure Psychopharmacology  1997 129:56-65  DOI:10.1007/s002130050162  PMID:9122364
    • Schulteis, G., Gold, L. H., Koob, G. F. Preclinical behavioral models for addressing unmet needs in opiate addiction Seminars in Neuroscience  1997 9:94-109  DOI:10.1006/smns.1997.0110
    • Roberts, A. J., Koob, G. F. The neurobiology of addiction: an overview Alcohol Health and Research World  1997 21:101-106  PMID:15704343
    • Koob, G. F., Nestler, E. J. The neurobiology of drug addiction Journal of Neuropsychiatry and Clinical Neurosciences  1997 9:482-497  PMID:9276849
    • Parsons, L. H., Koob, G. F., Weiss, F. Extracellular serotonin is decreased in the nucleus accumbens during withdrawal from cocaine self-administration Behavioural Brain Research  1996 73:225-228  DOI:10.1016/0166-4328(96)00101-5  PMID:8788507
    • ProsperoGarcia, O., Gold, L. H., Fox, H. S., Polis, I., Koob, G. F., Bloom, F. E., Henriksen, S. J. Microglia-passaged simian immunodeficiency virus induces neurophysiological abnormalities in monkeys Proceedings of the National Academy of Sciences of the United States of America  1996 93:14158-14163  DOI:10.1073/pnas.93.24.14158  PMID:8943077
    • Schulteis, G., Koob, G. F. Reinforcement processes in opiate addiction: A homeostatic model Neurochemical Research  1996 21:1437-1454  DOI:10.1007/bf02532385  PMID:8947934
    • Parsons, L. H., Weiss, F., Koob, G. F. Serotonin(1B) receptor stimulation enhances dopamine mediated reinforcement Psychopharmacology  1996 128:150-160  DOI:10.1007/s002130050120  PMID:8956376
    • Roberts, A. J., Cole, M., Koob, G. F. Intra-amygdala muscimol decreases operant ethanol self-administration in dependent rats Alcoholism-Clinical and Experimental Research  1996 20:1289-1298  DOI:10.1111/j.1530-0277.1996.tb01125.x  PMID:8904984
    • Solbrig, M. V., Koob, G. F., Fallon, J. H., Reid, S., Lipkin, W. I. Prefrontal cortex dysfunction in borna disease virus (bdv)-infected rats Biological Psychiatry  1996 40:629-636  DOI:10.1016/0006-3223(95)00480-7  PMID:8886296
    • Spina, M., MerloPich, E., Chan, R. K. W., Basso, A. M., Rivier, J., Vale, W., Koob, G. F. Appetite-suppressing effects of urocortin, a crf-related neuropeptide Science  1996 273:1561-1564  DOI:10.1126/science.273.5281.1561  PMID:8703220
    • Heinrichs, S. C., StenzelPoore, M. P., Gold, L. H., Battenberg, E., Bloom, F. E., Koob, G. F., Vale, W. W., Pich, E. M. Learning impairment in transgenic mice with central overexpression of corticotropin-releasing factor Neuroscience  1996 74:303-311  DOI:10.1016/0306-4522(96)00140-6  PMID:8865183
    • Vankova, M. E., Weinger, M. B., Chen, D. Y., Bronson, J. B., Motis, V., Koob, G. F. Role of central mu, delta-1, and kappa-1 opioid receptors in opioid-induced muscle rigidity in the rat Anesthesiology  1996 85:574-583  DOI:10.1097/00000542-199609000-00017  PMID:8853088
    • Solbrig, M. V., Koob, G. F., Joyce, J. N., Lipkin, W. I. A neural substrate of hyperactivity in borna disease: Changes in brain dopamine receptors Virology  1996 222:332-338  DOI:10.1006/viro.1996.0430  PMID:8806517
    • Weissenborn, R., Deroche, V., Koob, G. F., Weiss, F. Effects of dopamine agonists and antagonists on cocaine induced operant responding for a cocaine-associated stimulus Psychopharmacology  1996 126:311-322  PMID:8878347
    • Menzaghi, F., Heinrichs, S. C., VargasCortes, M., Goldstein, G., Koob, G. F. Iri-514, a synthetic peptide analogue of thymopentin, reduces the behavioral response to social stress in rats Physiology & Behavior  1996 60:397-401  DOI:10.1016/0031-9384(96)00034-0  PMID:8840897
    • Koob, G. F. Hedonic valence, dopamine and motivation Molecular Psychiatry  1996 1:186-189  PMID:9118342
    • delaTorre, J. C., Mallory, M., Brot, M., Gold, L., Koob, G., Oldstone, M. B. A., Masliah, E. Viral persistence in neurons alters synaptic plasticity and cognitive functions without destruction of brain cells Virology  1996 220:508-515  DOI:10.1006/viro.1996.0340  PMID:8661403
    • Hyytia, P., Schulteis, G., Koob, G. F. Intravenous heroin and ethanol self administration by alcohol preferring aa and alcohol-avoiding ana rats Psychopharmacology  1996 125:248-254  DOI:10.1007/bf02247335  PMID:8815960
    • Matthews, K., Baldo, B. A., Markou, A., Lown, O., Overstreet, D. H., Koob, G. F. Rewarding electrical brain stimulation: Similar thresholds for flinders sensitive line hypercholinergic and flinders resistant line hypocholinergic rats Physiology & Behavior  1996 59:1155-1162  DOI:10.1016/0031-9384(95)02212-0  PMID:8737906
    • Weiss, F., Parsons, L. H., Schulteis, G., Hyytia, P., Lorang, M. T., Bloom, F. E., Koob, G. F. Ethanol self-administration restores withdrawal-associated deficiencies in accumbal dopamine and 5-hydroxytryptamine release in dependent rats Journal of Neuroscience  1996 16:3474-3485  PMID:8627380
    • Koob, G. F. Drug addiction: The yin and yang of hedonic homeostasis Neuron  1996 16:893-896  DOI:10.1016/s0896-6273(00)80109-9  PMID:8630244
    • Korte, S. M., KorteBouws, G. A. H., Koob, G. F., DeKloet, E. R., Bohus, B. Mineralocorticoid and glucocorticoid receptor antagonists in animal models of anxiety Pharmacology, Biochemistry and Behavior  1996 54:261-267  DOI:10.1016/0091-3057(95)02172-8  PMID:8728567
    • Solbrig, M. V., Koob, G. F., Lipkin, W. I. Naloxone-induced seizures in rats infected with borna disease virus Neurology  1996 46:1170-1171  PMID:8780117
    • Macey, D. J., Schulteis, G., Heinrichs, S. C., Koob, G. F. Time-dependent quantifiable withdrawal from ethanol in the rat: Effect of method of dependence induction Alcohol  1996 13:163-170  DOI:10.1016/0741-8329(95)02030-6  PMID:8814651
    • Bono, G., Balducci, C., Richelmi, P., Koob, G. F., Pulvirenti, L. Dopamine partial receptor agonists reduce ethanol intake in the rat European Journal of Pharmacology  1996 296:233-238  DOI:10.1016/0014-2999(95)00592-7  PMID:8904074
    • Schulteis, G., Hyytia, P., Heinrichs, S. C., Koob, G. F. Effects of chronic ethanol exposure on oral self-administration of ethanol or saccharin by wistar rats Alcoholism-Clinical and Experimental Research  1996 20:164-171  DOI:10.1111/j.1530-0277.1996.tb01060.x  PMID:8651448
    • deFonseca, F. R., Rubio, P., Menzaghi, F., MerloPich, E., Rivier, J., Koob, G. F., Navarro, M. Corticotropin-releasing factor (crf) antagonist d-phe(12),nle(21,38),c(alpha)meleu(37) crf attenuates the acute actions of the highly potent cannabinoid receptor agonist hu-210 on defensive-withdrawal behavior in rats Journal of Pharmacology and Experimental Therapeutics  1996 276:56-64  PMID:8558457
    • Pulvirenti, L., Balducci, C., Koob, G. F. Inhibition of nitric oxide synthesis reduces intravenous cocaine self-administration in the rat Neuropharmacology  1996 35:1811-1814  DOI:10.1016/s0028-3908(96)00152-9  PMID:9076761
    • Parsons, L. H., Caine, S. B., Sokoloff, P., Schwartz, J. C., Koob, G. F., Weiss, F. Neurochemical evidence that postsynaptic nucleus accumbens D3 receptor stimulation enhances cocaine reinforcement Journal of Neurochemistry  1996 67:1078-1089  DOI:10.1046/j.1471-4159.1996.67031078.x  PMID:8752115
    • Carrera, M. R. A., Ashley, J. A., Parsons, L. H., Wirsching, P., Koob, G. F., Janda, K. D. Suppression of psychoactive effects of cocaine by active immunization Nature  1995 378:727-730  DOI:10.1038/378727a0  PMID:7501020
    • Caine, S. B., Heinrichs, S. C., Coffin, V. L., Koob, G. F. Effects of the dopamine d-1 antagonist sch-23390 microinjected into the accumbens, amygdala or striatum on cocaine self-administration in the rat Brain Research  1995 692:47-56  PMID:8548319
    • Hyytia, P., Koob, G. F. Gaba(a) receptor antagonism in the extended amygdala decreases ethanol self-administration in rats European Journal of Pharmacology  1995 283:151-159  DOI:10.1016/0014-2999(95)00314-b  PMID:7498304
    • Parsons, L. H., Koob, G. F., Weiss, F. Serotonin dysfunction in the nucleus accumbens of rats during withdrawal after unlimited access to intravenous cocaine Journal of Pharmacology and Experimental Therapeutics  1995 274:1182-1191  PMID:7562486
    • Schulteis, G., Markou, A., Cole, M., Koob, G. F. Decreased brain reward produced by ethanol withdrawal Proceedings of the National Academy of Sciences of the United States of America  1995 92:5880-5884  DOI:10.1073/pnas.92.13.5880  PMID:7597046
    • Weissenborn, R., Yackey, M., Koob, G. F., Weiss, F. Measures of cocaine-seeking behavior using a multiple schedule of food and drug self-administration in rats Drug and Alcohol Dependence  1995 38:237-246  DOI:10.1016/0376-8716(95)01107-a  PMID:7555624
    • Caine, S. B., Koob, G. F. Pretreatment with the dopamine agonist 7-oh-dpat shifts the cocaine self-administration dose-effect function to the left under different schedules in the rat Behavioural Pharmacology  1995 6:333-347  PMID:11224342
    • Richter, R. M., Pich, E. M., Koob, G. F., Weiss, F. Sensitization of cocaine-stimulated increase in extracellular levels of corticotropin-releasing factor from the rat amygdala after repeated administration as determined by intracranial microdialysis Neuroscience Letters  1995 187:169-172  DOI:10.1016/0304-3940(95)11365-4  PMID:7624019
    • Defonseca, F. R., Rubio, P., Martincalderon, J. L., Caine, S. B., Koob, G. F., Navarro, M. The dopamine-receptor agonist 7-oh-dpat modulates the acquisition and expression of morphine-induced place preference European Journal of Pharmacology  1995 274:47-55  DOI:10.1016/0014-2999(94)00708-f  PMID:7768280
    • Withers, N. W., Pulvirenti, L., Koob, G. F., Gillin, J. C. Cocaine abuse and dependence Journal of Clinical Psychopharmacology  1995 15:63-78  DOI:10.1097/00004714-199502000-00010  PMID:7714230
    • Raber, J., Koob, G. F., Bloom, F. E. Interleukin-2 (il-2) induces corticotropin-releasing factor (crf) release from the amygdala and involves a nitric oxide-mediated signaling - comparison with the hypothalamic response Journal of Pharmacology and Experimental Therapeutics  1995 272:815-824  PMID:7853199
    • Weinger, M. B., Chen, D. Y., Lin, T., Lau, C., Koob, G. F., Smith, N. T. A role for cns alpha-2-adrenergic receptors in opiate-induced muscle rigidity in the rat Brain Research  1995 669:10-18  DOI:10.1016/0006-8993(94)01216-5  PMID:7712151
    • Heinrichs, S. C., Menzaghi, F., Schulteis, G., Koob, G. F., Stinus, L. Suppression of corticotropin-releasing factor in the amygdala attenuates aversive consequences of morphine-withdrawal Behavioural Pharmacology  1995 6:74-80  PMID:11224314
    • Mitler, M. M., Aldrich, M. S., Koob, G. F., Zarcone, V. P. Narcolepsy and its treatment with stimulants Sleep  1994 17:352-371  PMID:7973321
    • Schulteis, G., Markou, A., Gold, L. H., Stinus, L., Koob, G. F. Relative sensitivity to naloxone of multiple indexes of opiate withdrawal - a quantitative dose-response analysis Journal of Pharmacology and Experimental Therapeutics  1994 271:1391-1398  PMID:7996451
    • Pulvirenti, L., Berrier, R., Kreifeldt, M., Koob, G. F. Modulation of locomotor-activity by nmda receptors in the nucleus-accumbens core and shell regions of the rat Brain Research  1994 664:231-236  DOI:10.1016/0006-8993(94)91977-1  PMID:7895034
    • Xu, M., Moratalla, R., Gold, L. H., Hiroi, N., Koob, G. F., Graybiel, A. M., Tonegawa, S. Dopamine d1 receptor mutant mice are deficient in striatal expression of dynorphin and in dopamine-mediated behavioral-responses Cell  1994 79:729-742  DOI:10.1016/0092-8674(94)90557-6  PMID:7954836
    • Markou, A., Matthews, K., Overstreet, D. H., Koob, G. F., Geyer, M. A. Flinders resistant hypocholinergic rats exhibit startle sensitization and reduced startle thresholds Biological Psychiatry  1994 36:680-688  DOI:10.1016/0006-3223(94)91177-0  PMID:7880937
    • Heinrichs, S. C., Menzaghi, F., Pich, E. M., Baldwin, H. A., Rassnick, S., Britton, K. T., Koob, G. F. Antistress action of a corticotropin-releasing factor antagonist on behavioral reactivity to stressors of varying type and intensity Neuropsychopharmacology  1994 11:179-186  DOI:10.1038/sj.npp.1380104  PMID:786509
    • Pulvirenti, L., Koob, G. F. Dopamine-receptor agonists, partial agonists and psychostimulant addiction Trends in Pharmacological Sciences  1994 15:374-379  DOI:10.1016/0165-6147(94)90158-9  PMID:7809953
    • Gold, L. H., Brot, M. D., Polis, I., Schroeder, R., Tishon, A., Delatorre, J. C., Oldstone, M. B. A., Koob, G. F. Behavioral-effects of persistent lymphocytic choriomeningitis virus-infection in mice Behavioral and Neural Biology  1994 62:100-109  DOI:10.1016/s0163-1047(05)80031-7  PMID:7993301
    • Korte, S. M., Kortebouws, G. A. H., Bohus, B., Koob, G. F. Effect of corticotropin-releasing factor antagonist on behavioral and neuroendocrine responses during exposure to defensive burying paradigm in rats Physiology & Behavior  1994 56:115-120  DOI:10.1016/0031-9384(94)90268-2  PMID:8084889
    • Caine, S. B., Koob, G. F. Effects of dopamine d-1 and d-2 antagonists on cocaine self-administration under different schedules of reinforcement in the rat Journal of Pharmacology and Experimental Therapeutics  1994 270:209-218  PMID:8035317
    • Gillin, J. C., Pulvirenti, L., Withers, N., Golshan, S., Koob, G. The effects of lisuride on mood and sleep during acute withdrawal in stimulant abusers - a preliminary-report Biological Psychiatry  1994 35:843-849  PMID:8054406
    • Menzaghi, F., Howard, R. L., Heinrichs, S. C., Vale, W., Rivier, J., Koob, G. F. Characterization of a novel and potent corticotropin-releasing factor antagonist in rats Journal of Pharmacology and Experimental Therapeutics  1994 269:564-572  PMID:8182523
    • Stenzelpoore, M. P., Heinrichs, S. C., Rivest, S., Koob, G. F., Vale, W. W. Overproduction of corticotropin-releasing factor in transgenic mice - a genetic model of anxiogenic behavior Journal of Neuroscience  1994 14:2579-2584  PMID:8182429
    • Pulvirenti, L., Koob, G. F. Lisuride reduces intravenous cocaine self-administration in rats Pharmacology, Biochemistry and Behavior  1994 47:819-822  DOI:10.1016/0091-3057(94)90281-x  PMID:8029249
    • Cole, B. J., Koob, G. F. Corticotropin-releasing factor and schedule-induced-polydipsia Pharmacology, Biochemistry and Behavior  1994 47:393-398  DOI:10.1016/0091-3057(94)90134-1  PMID:8208756
    • Caine, S. B., Koob, G. F. Effects of mesolimbic dopamine depletion on responding maintained by cocaine and food Journal of the Experimental Analysis of Behavior  1994 61:213-221  DOI:10.1901/jeab.1994.61-213  PMID:8169570  PMCID:PMC1334409
    • Raber, J., Pich, E. M., Koob, G. F., Bloom, F. E. Il-1-beta potentiates the acetylcholine-induced release of vasopressin from the hypothalamus in-vitro, but not from the amygdala Neuroendocrinology  1994 59:208-217  DOI:10.1159/000126661  PMID:8159270
    • Menzaghi, F., Heinrichs, S. C., Merlopich, E., Tilders, F. J. H., Koob, G. F. Involvement of hypothalamic corticotropin-releasing factor neurons in behavioral-responses to novelty in rats Neuroscience Letters  1994 168:139-142  DOI:10.1016/0304-3940(94)90435-9  PMID:8028766
    • Gold, L. H., Stinus, L., Inturrisi, C. E., Koob, G. F. Prolonged tolerance, dependence and abstinence following subcutaneous morphine pellet implantation in the rat European Journal of Pharmacology  1994 253:45-51  DOI:10.1016/0014-2999(94)90755-2  PMID:8013548
    • Heilig, M., Koob, G. F., Ekman, R., Britton, K. T. Corticotropin-releasing factor and neuropeptide-y - role in emotional integration Trends in Neurosciences  1994 17:80-85  DOI:10.1016/0166-2236(94)90079-5  PMID:7512773
    • Koob, G. F., Caine, B., Markou, A., Pulvirenti, L., Weiss, F. Role for the mesocortical dopamine system in the motivating effects of cocaine NIDA Research Monograph  1994 145:1-18  PMID:8742805
    • Pulvirenti, L., Smith, D., Koob, G. F. Sdz 208-911, an amino-ergoline with partial dopamine agonist properties, dose-dependently increases cocaine self-administration in the rat Psychopharmacology  1994 113:518-520  DOI:10.1007/bf02245232  PMID:7862868
    • Weiss, F., Lorang, M. T., Bloom, F. E., Koob, G. F. Oral alcohol self-administration stimulates dopamine release in the rat nucleus-accumbens - genetic and motivational determinants Journal of Pharmacology and Experimental Therapeutics  1993 267:250-258  PMID:8229752
    • Rassnick, S., Stinus, L., Koob, G. F. The effects of 6-hydroxydopamine lesions of the nucleus-accumbens and the mesolimbic dopamine system on oral self-administration of ethanol in the rat Brain Research  1993 623:16-24  DOI:10.1016/0006-8993(93)90004-7  PMID:8221085
    • Robledo, P., Maldonado, R., Koob, G. F. Neurotensin injected into the nucleus-accumbens blocks the psychostimulant effects of cocaine but does not attenuate cocaine self-administration in the rat Brain Research  1993 622:105-112  DOI:10.1016/0006-8993(93)90808-z  PMID:8242350
    • Markou, A., Weiss, F., Gold, L. H., Caine, S. B., Schulteis, G., Koob, G. F. Animal-models of drug craving Psychopharmacology  1993 112:163-182  DOI:10.1007/bf02244907  PMID:7871016
    • Pich, E. M., Koob, G. F., Heilig, M., Menzaghi, F., Vale, W., Weiss, F. Corticotropin-releasing factor release from the mediobasal hypothalamus of the rat as measured by microdialysis Neuroscience  1993 55:695-707  DOI:10.1016/0306-4522(93)90435-i  PMID:8413932
    • Koob, G. F., Cador, M. Psychomotor stimulant sensitization - the corticotropin-releasing factor steroid connection - commentary on psychomotor-stimulant sensitization - a unitary phenomenon Behavioural Pharmacology  1993 4:351-354  PMID:11224203
    • Menzaghi, F., Heinrichs, S. C., Pich, E. M., Tilders, F. J. H., Koob, G. F. Functional impairment of hypothalamic corticotropin-releasing factor neurons with immunotargeted toxins enhances food-intake induced by neuropeptide-y Brain Research  1993 618:76-82  DOI:10.1016/0006-8993(93)90431-l  PMID:8402180
    • Swerdlow, N. R., Koob, G. F., Cador, M., Lorang, M., Hauger, R. L. Pituitary-adrenal axis responses to acute amphetamine in the rat Pharmacology, Biochemistry and Behavior  1993 45:629-637  DOI:10.1016/0091-3057(93)90518-x  PMID:8392732
    • Robledo, P., Koob, G. F. Two discrete nucleus accumbens projection areas differentially mediate cocaine self-administration in the rat Behavioural Brain Research  1993 55:159-166  DOI:10.1016/0166-4328(93)90112-4  PMID:8395179
    • Caine, S. B., Koob, G. F. Modulation of cocaine self-administration in the rat through d-3 dopamine-receptors Science  1993 260:1814-1816  DOI:10.1126/science.8099761  PMID:8099761
    • Heilig, M., McLeod, S., Brot, M., Heinrichs, S. C., Menzaghi, F., Koob, G. F., Britton, K. T. Anxiolytic-like action of neuropeptide-y - mediation by y1 receptors in amygdala, and dissociation from food-intake effects Neuropsychopharmacology  1993 8:357-363  PMID:809979
    • Negus, S. S., Henriksen, S. J., Mattox, A., Pasternak, G. W., Portoghese, P. S., Takemori, A. E., Weinger, M. B., Koob, G. F. Effect of antagonists selective for mu-opioid, delta-opioid and kappa-opioid receptors on the reinforcing effects of heroin in rats Journal of Pharmacology and Experimental Therapeutics  1993 265:1245-1252  PMID:8389859
    • Heinrichs, S. C., Menzaghi, F., Pich, E. M., Hauger, R. L., Koob, G. F. Corticotropin-releasing factor in the paraventricular nucleus modulates feeding induced by neuropeptide-y Brain Research  1993 611:18-24  DOI:10.1016/0006-8993(93)91771-j  PMID:8518948
    • Maldonado, R., Robledo, P., Chover, A. J., Caine, S. B., Koob, G. F. D(1) dopamine-receptors in the nucleus-accumbens modulate cocaine self-administration in the rat Pharmacology, Biochemistry and Behavior  1993 45:239-242  DOI:10.1016/0091-3057(93)90112-7  PMID:8516365
    • Pulvirenti, L., Koob, G. F. Lisuride reduces psychomotor retardation during withdrawal from chronic intravenous amphetamine self-administration in rats Neuropsychopharmacology  1993 8:213-218  PMID:850734
    • Amalric, M., Berhow, M., Polis, I., Koob, G. F. Selective effects of low-dose d2-dopamine receptor antagonism in a reaction-time-task in rats Neuropsychopharmacology  1993 8:195-200  PMID:850734
    • Hammer, R. P., Pires, W. S., Markou, A., Koob, G. F. Withdrawal following cocaine self-administration decreases regional cerebral metabolic-rate in critical brain reward regions Synapse  1993 14:73-80  DOI:10.1002/syn.890140110  PMID:8511720
    • Rassnick, S., Krechman, J., Koob, G. F. Chronic ethanol produces a decreased sensitivity to the response-disruptive effects of gaba receptor complex antagonists Pharmacology, Biochemistry and Behavior  1993 44:943-950  DOI:10.1016/0091-3057(93)90029-s  PMID:8385785
    • Cador, M., Cole, B. J., Koob, G. F., Stinus, L., Lemoal, M. Central administration of corticotropin releasing-factor induces long-term sensitization to d-amphetamine Brain Research  1993 606:181-186  DOI:10.1016/0006-8993(93)90982-s  PMID:8490714
    • Maldonado, R., Koob, G. F. Destruction of the locus-ceruleus decreases physical signs of opiate withdrawal Brain Research  1993 605:128-138  DOI:10.1016/0006-8993(93)91364-x  PMID:8467382
    • Rassnick, S., Heinrichs, S. C., Britton, K. T., Koob, G. F. Microinjection of a corticotropin-releasing factor antagonist into the central nucleus of the amygdala reverses anxiogenic-like effects of ethanol withdrawal Brain Research  1993 605:25-32  DOI:10.1016/0006-8993(93)91352-s  PMID:8467387
    • Rassnick, S., Pulvirenti, L., Koob, G. F. Sdz-205,152, a novel dopamine receptor agonist, reduces oral ethanol self-administration in rats Alcohol  1993 10:127-132  DOI:10.1016/0741-8329(93)90091-2  PMID:8095143
    • Negus, S. S., Pasternak, G. W., Koob, G. F., Weinger, M. B. Antagonist effects of beta-funaltrexamine and naloxonazine on alfentanil-induced antinociception and muscle rigidity in the rat Journal of Pharmacology and Experimental Therapeutics  1993 264:739-745  PMID:8437122
    • Rassnick, S., Damico, E., Riley, E., Koob, G. F. Gaba antagonist and benzodiazepine partial inverse agonist reduce motivated responding for ethanol Alcoholism-Clinical and Experimental Research  1993 17:124-130  DOI:10.1111/j.1530-0277.1993.tb00736.x  PMID:8383923
    • Wahlestedt, C., Pich, E. M., Koob, G. F., Yee, F., Heilig, M. Modulation of anxiety and neuropeptide-y-y1 receptors by antisense oligodeoxynucleotides Science  1993 259:528-531  DOI:10.1126/science.8380941  PMID:8380941
    • Pich, E. M., Heinrichs, S. C., Rivier, C., Miczek, K. A., Fisher, D. A., Koob, G. F. Blockade of pituitary-adrenal axis activation-induced by peripheral immunoneutralization of corticotropin-releasing factor does not affect the behavioral-response to social defeat stress in rats Psychoneuroendocrinology  1993 18:495-507  PMID:82657
    • Koob, G. F., Markou, A., Weiss, F., Schulteis, G. Opponent process and drug dependence: neurobiological mechanisms Seminars in Neuroscience  1993 5:351-358  DOI:10.1016/S1044-5765(05)80043-0
    • Baldwin, H. A., Koob, G. F. Rapid induction of conditioned opiate withdrawal in the rat Neuropsychopharmacology  1993 8:15-21  PMID:8424845
    • Koob, G. F., Heinrichs, S. C., Pich, E. M., Menzaghi, F., Baldwin, H., Miczek, K., Britton, K. T. The role of corticotropin-releasing factor in behavioral-responses to stress Ciba Foundation Symposia  1993 172:277-295  PMID:8491090
    • Cador, M., Ahmed, S. H., Koob, G. F., Lemoal, M., Stinus, L. Corticotropin-releasing factor induces a place aversion independent of its neuroendocrine role Brain Research  1992 597:304-309  DOI:10.1016/0006-8993(92)91487-y  PMID:1473001
    • Maldonado, R., Negus, S., Koob, G. F. Precipitation of morphine-withdrawal syndrome in rats by administration of mu-selective, delta-selective and kappa-selective opioid antagonists Neuropharmacology  1992 31:1231-1241  DOI:10.1016/0028-3908(92)90051-p  PMID:1335131
    • Markou, A., Koob, G. F. Bromocriptine reverses the elevation in intracranial self-stimulation thresholds observed in a rat model of cocaine withdrawal Neuropsychopharmacology  1992 7:213-224  PMID:138864
    • Markou, A., Hauger, R. L., Koob, G. F. Desmethylimipramine attenuates cocaine withdrawal in rats Psychopharmacology  1992 109:305-314  DOI:10.1007/bf02245878  PMID:1365631
    • Weiss, F., Paulus, M. P., Lorang, M. T., Koob, G. F. Increases in extracellular dopamine in the nucleus-accumbens by cocaine are inversely related to basal levels - effects of acute and repeated administration Journal of Neuroscience  1992 12:4372-4380  PMID:1432099
    • Pulvirenti, L., Maldonadolopez, R., Koob, G. F. Nmda receptors in the nucleus-accumbens modulate intravenous cocaine but not heroin self-administration in the rat Brain Research  1992 594:327-330  DOI:10.1016/0006-8993(92)91145-5  PMID:1360323
    • Weiss, F., Markou, A., Lorang, M. T., Koob, G. F. Basal extracellular dopamine levels in the nucleus-accumbens are decreased during cocaine withdrawal after unlimited-access self-administration Brain Research  1992 593:314-318  DOI:10.1016/0006-8993(92)91327-b  PMID:1450939
    • Heinrichs, S. C., Koob, G. F. Corticotropin-releasing factor modulates dietary preference in nutritionally and physically stressed rats Psychopharmacology  1992 109:177-184  DOI:10.1007/bf02245497  PMID:1365653
    • Rassnick, S., Pulvirenti, L., Koob, G. F. Oral ethanol self-administration in rats is reduced by the administration of dopamine and glutamate receptor antagonists into the nucleus-accumbens Psychopharmacology  1992 109:92-98  DOI:10.1007/bf02245485  PMID:1365677
    • Heinrichs, S. C., Cole, B. J., Pich, E. M., Menzaghi, F., Koob, G. F., Hauger, R. L. Endogenous corticotropin-releasing factor modulates feeding induced by neuropeptide-y or a tail-pinch stressor Peptides  1992 13:879-884  DOI:10.1016/0196-9781(92)90044-4  PMID:1480513
    • Cador, M., Dumas, S., Cole, B. J., Mallet, J., Koob, G. F., Lemoal, M., Stinus, L. Behavioral sensitization induced by psychostimulants or stress - search for a molecular-basis and evidence for a crf-dependent phenomenon Annals of the New York Academy of Sciences  1992 654:416-420  DOI:10.1111/j.1749-6632.1992.tb25985.x  PMID:1352953
    • Rassnick, S., Damico, E., Riley, E., Pulvirenti, L., Zieglgansberger, W., Koob, G. F. Gaba and nucleus-accumbens glutamate neurotransmission modulate ethanol self-administration in rats Annals of the New York Academy of Sciences  1992 654:502-505  PMID:1352956
    • Koob, G. F. Neural mechanisms of drug reinforcement Annals of the New York Academy of Sciences  1992 654:171-191  DOI:10.1111/j.1749-6632.1992.tb25966.x  PMID:1632582
    • Weiss, F., Hurd, Y. L., Ungerstedt, U., Markou, A., Plotsky, P. M., Koob, G. F. Neurochemical correlates of cocaine and ethanol self-administration Annals of the New York Academy of Sciences  1992 654:220-241  DOI:10.1111/j.1749-6632.1992.tb25970.x  PMID:1632585
    • Robledo, P., Maldonadolopez, R., Koob, G. F. Role of dopamine-receptors in the nucleus-accumbens in the rewarding properties of cocaine Annals of the New York Academy of Sciences  1992 654:509-512  DOI:10.1111/j.1749-6632.1992.tb26015.x  PMID:1385935
    • Heinrichs, S. C., Pich, E. M., Miczek, K. A., Britton, K. T., Koob, G. F. Corticotropin-releasing factor antagonist reduces emotionality in socially defeated rats via direct neurotropic action Brain Research  1992 581:190-197  DOI:10.1016/0006-8993(92)90708-h  PMID:1327398
    • Koob, G. F. Drugs of abuse - anatomy, pharmacology and function of reward pathways Trends in Pharmacological Sciences  1992 13:177-184  DOI:10.1016/0165-6147(92)90060-j  PMID:1604710
    • Koob, G. F., Maldonado, R., Stinus, L. Neural substrates of opiate withdrawal Trends in Neurosciences  1992 15:186-191  DOI:10.1016/0166-2236(92)90171-4  PMID:1377426
    • Maldonado, R., Stinus, L., Gold, L. H., Koob, G. F. Role of different brain structures in the expression of the physical morphine-withdrawal syndrome Journal of Pharmacology and Experimental Therapeutics  1992 261:669-677  PMID:1578378
    • Weinberger, S. B., Koob, G. F., Martinez, J. L. Differences in one-way active-avoidance learning in mice of 3 inbred strains Behavior Genetics  1992 22:177-188  DOI:10.1007/bf01066996  PMID:1596257
    • Rassnick, S., Koob, G. F., Geyer, M. A. Responding to acoustic startle during chronic ethanol intoxication and withdrawal Psychopharmacology  1992 106:351-358  DOI:10.1007/bf02245417  PMID:1570382
    • Britton, K. T., McLeod, S., Koob, G. F., Hauger, R. Pregnane steroid alphaxalone attenuates anxiogenic behavioral-effects of corticotropin releasing-factor and stress Pharmacology, Biochemistry and Behavior  1992 41:399-403  DOI:10.1016/0091-3057(92)90117-x  PMID:1315440
    • Markou, A., Koob, G. F. Construct-validity of a self-stimulation threshold paradigm - effects of reward and performance manipulations Physiology & Behavior  1992 51:111-119  DOI:10.1016/0031-9384(92)90211-j  PMID:1741436
    • Heinrichs, S. C., Britton, K. T., Koob, G. F. Both conditioned taste preference and aversion induced by corticotropin-releasing factor Pharmacology, Biochemistry and Behavior  1991 40:717-721  DOI:10.1016/0091-3057(91)90075-d  PMID:1667823
    • Bluthe, R. M., Koob, G. F., Dantzer, R. Hypertonic saline mimics the effects of vasopressin and social recognition in rats Behavioural Pharmacology  1991 2:513-516  PMID:11224093
    • Pulvirenti, L., Swerdlow, N. R., Koob, G. F. Nucleus-accumbens nmda antagonist decreases locomotor-activity produced by cocaine, heroin or accumbens dopamine, but not caffeine Pharmacology, Biochemistry and Behavior  1991 40:841-845  DOI:10.1016/0091-3057(91)90095-j  PMID:1687766
    • Baldwin, H. A., Wall, T. L., Schuckit, M. A., Koob, G. F. Differential-effects of ethanol on punished responding in the p-rats and np-rats Alcoholism-Clinical and Experimental Research  1991 15:700-704  DOI:10.1111/j.1530-0277.1991.tb00582.x  PMID:1928646
    • Swerdlow, N. R., Hauger, R., Irwin, M., Koob, G. F., Britton, K. T., Pulvirenti, L. Endocrine, immune, and neurochemical changes in rats during withdrawal from chronic amphetamine intoxication Neuropsychopharmacology  1991 5:23-31  PMID:1657016
    • Britton, K. T., Page, M., Baldwin, H., Koob, G. F. Anxiolytic activity of steroid anesthetic alphaxalone Journal of Pharmacology and Experimental Therapeutics  1991 258:124-129  PMID:1677035
    • Weinger, M. B., Smith, N. T., Blasco, T. A., Koob, G. F. Brain sites mediating opiate-induced muscle rigidity in the rat - methylnaloxonium mapping study Brain Research  1991 544:181-190  DOI:10.1016/0006-8993(91)90052-w  PMID:2039935
    • Schroeder, R. L., Weinger, M. B., Vakassian, L., Koob, G. F. Methylnaloxonium diffuses out of the rat-brain more slowly than naloxone after direct intracerebral injection Neuroscience Letters  1991 121:173-177  DOI:10.1016/0304-3940(91)90678-m  PMID:2020373
    • Baldwin, H. A., Rassnick, S., Rivier, J., Koob, G. F., Britton, K. T. Crf antagonist reverses the anxiogenic response to ethanol withdrawal in the rat Psychopharmacology  1991 103:227-232  DOI:10.1007/bf02244208  PMID:2027923
    • Markou, A., Koob, G. F. Postcocaine anhedonia: an animal model of cocaine withdrawal Neuropsychopharmacology  1991 4:17-26  PMID:2003866
    • Ehlers, C. L., Chaplin, R. I., Koob, G. F. EEG effects of RO-15-4513 and FG-7142 alone and in combination with ethanol Pharmacology, Biochemistry and Behavior  1990 36:607-611  DOI:10.1016/0091-3057(90)90263-h  PMID:2165619
    • Koob, G. F., Weiss, F. Pharmacology of drug self-administration Alcohol  1990 7:193-197  DOI:10.1016/0741-8329(90)90004-v  PMID:1970479
    • Cole, B. J., Cador, M., Stinus, L., Rivier, J., Vale, W., Koob, G. F., Lemoal, M. Central administration of a crf antagonist blocks the development of stress-induced behavioral sensitization Brain Research  1990 512:343-346  DOI:10.1016/0006-8993(90)90646-s  PMID:2354366
    • Hubner, C. B., Koob, G. F. Bromocriptine produces decreases in cocaine self-administration in the rat Neuropsychopharmacology  1990 3:101-108  PMID:231726
    • Weinger, M. B., Schreiber, J. F., Koob, G. F. Effects of 2 benzodiazepine inverse agonists, ro-15-4513 and fg-7142, on recovery from pentobarbital and halothane anesthesia in the rat Pharmacology, Biochemistry and Behavior  1990 35:889-895  DOI:10.1016/0091-3057(90)90376-s  PMID:2111915
    • Swerdlow, N. R., Koob, G. F. Toward a unified hypothesis of cortico-striato-pallido-thalamus function? Behavioral and Brain Sciences  1990 13:172-177  DOI:10.1017/S0140525X00078195
    • Hurd, Y. L., Weiss, F., Koob, G., Ungerstedt, U. The influence of cocaine self-administration on in vivo dopamine and acetylcholine neurotransmission in rat caudate-putamen Neuroscience Letters  1990 109:227-233  DOI:10.1016/0304-3940(90)90568-t  PMID:2314639
    • Hubner, C. B., Koob, G. F. The ventral pallidum plays a role in mediating cocaine and heroin self-administration in the rat Brain Research  1990 508:20-29  DOI:10.1016/0006-8993(90)91112-t  PMID:2337788
    • Swerdlow, N. R., Mansbach, R. S., Geyer, M. A., Pulvirenti, L., Koob, G. F., Braff, D. L. Amphetamine disruption of prepulse inhibition of acoustic startle is reversed by depletion of mesolimbic dopamine Psychopharmacology  1990 100:413-416  DOI:10.1007/bf02244616  PMID:2315438
    • Cole, B. J., Cador, M., Stinus, L., Rivier, C., Rivier, J., Vale, W., Lemoal, M., Koob, G. F. Critical role of the hypothalamic pituitary-adrenal axis in amphetamine-induced sensitization of behavior Life Sciences  1990 47:1715-1720  DOI:10.1016/0024-3205(90)90344-q  PMID:2250584
    • Melia, K. F., Koob, G. F., Ehlers, C. L. Ethanol effects on delayed spatial matching as modeled by a negative exponential forgetting function Psychopharmacology  1990 102:391-398  DOI:10.1007/bf02244109  PMID:2251335
    • Weiss, F., Mitchiner, M., Bloom, F. E., Koob, G. F. Free-choice responding for ethanol versus water in alcohol preferring (p) and unselected wistar rats is differentially modified by naloxone, bromocriptine, and methysergide Psychopharmacology  1990 101:178-186  DOI:10.1007/bf02244123  PMID:2349359
    • Stinus, L., Lemoal, M., Koob, G. F. Nucleus-accumbens and amygdala are possible substrates for the aversive stimulus effects of opiate withdrawal Neuroscience  1990 37:767-773  DOI:10.1016/0306-4522(90)90106-e  PMID:2247222
    • Unterwald, E. M., Tempel, A., Koob, G. F., Zukin, R. S. Characterization of opioid receptors in rat nucleus accumbens following mesolimbic dopaminergic lesions Brain Research  1989 505:111-118  DOI:10.1016/0006-8993(89)90120-0  PMID:2558779
    • Swerdlow, N. R., Britton, K. T., Koob, G. F. Potentiation of acoustic startle by corticotropin-releasing factor (crf) and by fear are both reversed by alpha-helical crf (9-41) Neuropsychopharmacology  1989 2:285-292  DOI:10.1016/0893-133x(89)90033-x  PMID:261082
    • Koob, G. F., Lebrun, C., Bluthe, R. M., Dantzer, R., Lemoal, M. Role of neuropeptides in learning versus performance - focus on vasopressin Brain Research Bulletin  1989 23:359-364  DOI:10.1016/0361-9230(89)90222-0  PMID:2686806
    • Hurd, Y. L., Weiss, F., Koob, G. F., And, N. E., Ungerstedt, U. Cocaine reinforcement and extracellular dopamine overflow in rat nucleus accumbens: an in vivo microdialysis study Brain Research  1989 498:199-203  DOI:10.1016/0006-8993(89)90422-8  PMID:2790475
    • Pulvirenti, L., Swerdlow, N. R., Koob, G. F. Microinjection of a glutamate antagonist into the nucleus accumbens reduces psychostimulant locomotion in rats Neuroscience Letters  1989 103:213-218  DOI:10.1016/0304-3940(89)90578-8  PMID:2771183
    • Swerdlow, N. R., Koob, G. F. Norepinephrine stimulates behavioral activation in rats following depletion of nucleus accumbens dopamine Pharmacology, Biochemistry and Behavior  1989 33:595-599  DOI:10.1016/0091-3057(89)90394-8  PMID:2511575
    • Amalric, M., Koob, G. F. Dorsal pallidum as a functional motor output of the corpus striatum Brain Research  1989 483:389-394  DOI:10.1016/0006-8993(89)90186-8  PMID:2706530
    • Britton, K. T., Koob, G. F. Effects of corticotropin releasing-factor, desipramine and haloperidol on a drl schedule of reinforcement Pharmacology, Biochemistry and Behavior  1989 32:967-970  DOI:10.1016/0091-3057(89)90067-1  PMID:2798545
    • Gold, L. H., Hubner, C. B., Koob, G. F. A role for the mesolimbic dopamine system in the psychostimulant actions of mdma Psychopharmacology  1989 99:40-47  DOI:10.1007/bf00634450  PMID:2571175
    • Weiss, F., Ettenberg, A., Koob, G. F. Cck-8 injected into the nucleus accumbens attenuates the supersensitive locomotor response to apomorphine in 6-ohda and chronic-neuroleptic treated rats Psychopharmacology  1989 99:409-415  DOI:10.1007/bf00445568  PMID:2574480
    • Cole, B. J., Koob, G. F. Low-doses of corticotropin-releasing factor potentiate amphetamine-induced stereotyped behavior Psychopharmacology  1989 99:27-33  DOI:10.1007/bf00634448  PMID:2506602
    • Gold, L. H., Koob, G. F. Mdma produces stimulant-like conditioned locomotor-activity Psychopharmacology  1989 99:352-356  DOI:10.1007/bf00445556  PMID:2574478
    • Koob, G. F., Wall, T. L., Bloom, F. E. Nucleus accumbens as a substrate for the aversive stimulus effects of opiate withdrawal Psychopharmacology  1989 98:530-534  DOI:10.1007/bf00441954  PMID:2505294
    • Koob, G. F., Stinus, L., Lemoal, M., Bloom, F. E. Opponent process theory of motivation - neurobiological evidence from studies of opiate dependence Neuroscience and Biobehavioral Reviews  1989 13:135-140  DOI:10.1016/s0149-7634(89)80022-3  PMID:2682399
    • Hand, T. H., Koob, G. F., Stinus, L., Lemoal, M. Aversive properties of opiate receptor blockade - evidence for exclusively central mediation in naive and morphine-dependent rats Brain Research  1988 474:364-368  DOI:10.1016/0006-8993(88)90452-0  PMID:2463060
    • Cole, B. J., Koob, G. F. Propranolol antagonizes the enhanced conditioned fear produced by corticotropin releasing-factor Journal of Pharmacology and Experimental Therapeutics  1988 247:902-910  PMID:2849675
    • Koob, G. F., Bloom, F. E. Cellular and molecular mechanisms of drug-dependence Science  1988 242:715-723  DOI:10.1126/science.2903550  PMID:2903550
    • Koob, G. F., Mendelson, W. B., Schafer, J., Wall, T. L., Britton, K. T., Bloom, F. E. Picrotoxinin receptor ligand blocks anti-punishment effects of alcohol Alcohol  1988 5:437-443  DOI:10.1016/0741-8329(88)90079-1  PMID:2854473
    • Gold, L. H., Koob, G. F., Geyer, M. A. Stimulant and hallucinogenic behavioral profiles of 3,4-methylenedioxymethamphetamine and n-ethyl-3,4-methylenedioxyamphetamine in rats Journal of Pharmacology and Experimental Therapeutics  1988 247:547-555  PMID:2903234
    • Koob, G. F., Percy, L., Britton, K. T. The effects of ro-15-4513 on the behavioral actions of ethanol in an operant reaction-time task and a conflict test Pharmacology, Biochemistry and Behavior  1988 31:757-760  DOI:10.1016/0091-3057(88)90261-4  PMID:3251257
    • Koob, G. F., Swerdlow, N. R. The functional output of the mesolimbic dopamine system Annals of the New York Academy of Sciences  1988 537:216-227  DOI:10.1111/j.1749-6632.1988.tb42108.x  PMID:3059925
    • Dantzer, R., Koob, G. F., Bluthe, R. M., Lemoal, M. Septal vasopressin modulates social memory in male-rats Brain Research  1988 457:143-147  DOI:10.1016/0006-8993(88)90066-2  PMID:3167559
    • Gold, L. H., Swerdlow, N. R., Koob, G. F. The role of mesolimbic dopamine in conditioned locomotion produced by amphetamine Behavioral Neuroscience  1988 102:544-552  DOI:10.1037//0735-7044.102.4.544  PMID:3139012
    • Weinger, M. B., Cline, E. J., Smith, N. T., Blasco, T. A., Koob, G. F. Localization of brain-stem sites which mediate alfentanil-induced muscle rigidity in the rat Pharmacology, Biochemistry and Behavior  1988 29:573-580  DOI:10.1016/0091-3057(88)90022-6  PMID:3129743
    • Gold, L. H., Koob, G. F. Methysergide potentiates the hyperactivity produced by mdma in rats Pharmacology, Biochemistry and Behavior  1988 29:645-648  DOI:10.1016/0091-3057(88)90034-2  PMID:2896363
    • Britton, K. T., Ehlers, C. L., Koob, G. F. Is ethanol antagonist Ro15-4513 selective for ethanol Science  1988 239:648-649  DOI:10.1126/science.3340849  PMID:3340849
    • Britton, K. T., Lee, G., Koob, G. F. Corticotropin releasing-factor and amphetamine exaggerate partial agonist properties of benzodiazepine antagonist ro 15-1788 in the conflict test Psychopharmacology  1988 94:306-311  PMID:3128805
    • Dantzer, R., Terlouw, C., Tazi, A., Koolhaas, J. M., Bohus, B., Koob, G. F., Lemoal, M. The propensity for schedule-induced-polydipsia is related to differences in conditioned avoidance-behavior and in defense reactions in a defeat test Physiology & Behavior  1988 43:269-273  DOI:10.1016/0031-9384(88)90186-2  PMID:3174839
    • Koob, G. F., Wall, T. L., Schafer, J. Rapid induction of tolerance to the antipunishment effects of ethanol Alcohol  1987 4:481-484  DOI:10.1016/0741-8329(87)90090-5  PMID:3435637
    • Weinger, M. B., Cline, E. J., Smith, N. T., Koob, G. F. Ketanserin pretreatment reverses alfentanil-induced muscle rigidity Anesthesiology  1987 67:348-354  DOI:10.1097/00000542-198709000-00012  PMID:3115150
    • Koob, G. F., Le, H. T., Creese, I. The d1 dopamine receptor antagonist sch-23390 increases cocaine self-administration in the rat Neuroscience Letters  1987 79:315-320  DOI:10.1016/0304-3940(87)90451-4  PMID:2958724
    • Tazi, A., Swerdlow, N. R., Lemoal, M., Rivier, J., Vale, W., Koob, G. F. Behavioral activation by crf - evidence for the involvement of the ventral forebrain Life Sciences  1987 41:41-49  DOI:10.1016/0024-3205(87)90554-6  PMID:3496511
    • Tazi, A., Dantzer, R., Lemoal, M., Rivier, J., Vale, W., Koob, G. F. Corticotropin-releasing factor antagonist blocks stress-induced fighting in rats Regulatory Peptides  1987 18:37-42  DOI:10.1016/0167-0115(87)90048-6  PMID:3498188
    • Amalric, M., Koob, G. F. Depletion of dopamine in the caudate-nucleus but not in nucleus-accumbens impairs reaction-time performance in rats Journal of Neuroscience  1987 7:2129-2134  PMID:3112323
    • Lemoal, M., Dantzer, R., Michaud, B., Koob, G. F. Centrally injected arginine vasopressin (avp) facilitates social memory in rats Neuroscience Letters  1987 77:353-359  DOI:10.1016/0304-3940(87)90527-1  PMID:3614767
    • Swerdlow, N. R., Koob, G. F. Lesions of the dorsomedial nucleus of the thalamus, medial prefrontal cortex and pedunculopontine nucleus - effects on locomotor-activity mediated by nucleus accumbens-ventral pallidal circuitry Brain Research  1987 412:233-243  DOI:10.1016/0006-8993(87)91129-2  PMID:3607466
    • Ehlers, C. L., Chaplin, R. I., Koob, G. F. Antidepressants modulate the CNS effects of corticotropin releasing-factor in rats Medical Science Research-Biochemistry  1987 15:719-720
    • Swerdlow, N. R., Koob, G. F. Dopamine, schizophrenia, mania and depression - toward a unified hypothesis of cortico-striato-pallido-thalamic function Behavioral and Brain Sciences  1987 10:197-207
    • Swerdlow, N. R., Koob, G. F. Toward a unified neuropsychiatric hypothesis. Response Behavioral and Brain Sciences  1987 10:226-236
    • Swerdlow, N. R., Amalric, M., Koob, G. F. Nucleus-accumbens opiate-dopamine interactions and locomotor activation in the rat - evidence for a presynaptic locus Pharmacology, Biochemistry and Behavior  1987 26:765-769  DOI:10.1016/0091-3057(87)90609-5  PMID:3110795
    • Lebrun, C., Lemoal, M., Dantzer, R., Bloom, F. E., Koob, G. F. Hypertonic saline mimics the effects of vasopressin on inhibitory avoidance in the rat Behavioral and Neural Biology  1987 47:130-137  DOI:10.1016/s0163-1047(87)90229-9  PMID:3579833
    • Dantzer, R., Bluthe, R. M., Koob, G. F., Lemoal, M. Modulation of social memory in male-rats by neurohypophyseal peptides Psychopharmacology  1987 91:363-368  DOI:10.1007/bf00518192  PMID:3104959
    • Thatcherbritton, K., Koob, G. F. Alcohol reverses the proconflict effect of corticotropin-releasing factor Regulatory Peptides  1986 16:315-320  DOI:10.1016/0167-0115(86)90031-5  PMID:3031744
    • Amalric, M., Koob, G. F., Creese, I., Swerdlow, N. R. Selective d-1 and d-2 receptor antagonists fail to differentially alter supersensitive locomotor behavior in the rat Life Sciences  1986 39:1985-1993  DOI:10.1016/0024-3205(86)90322-x  PMID:2946915
    • Amalric, M., Blasco, T. A., Smith, N. T., Lee, D. E., Swerdlow, N. R., Koob, G. F. Catatonia produced by alfentanil is reversed by methylnaloxonium microinjections into the brain Brain Research  1986 386:287-295  DOI:10.1016/0006-8993(86)90165-4  PMID:3022882
    • Blasco, T. A., Lee, D., Amalric, M., Swerdlow, N. R., Smith, N. T., Koob, G. F. The role of the nucleus raphe pontis and the caudate-nucleus in alfentanil rigidity in the rat Brain Research  1986 386:280-286  DOI:10.1016/0006-8993(86)90164-2  PMID:3096494
    • Britton, K. T., Lee, G., Dana, R., Risch, S. C., Koob, G. F. Activating and anxiogenic effects of corticotropin releasing-factor are not inhibited by blockade of the pituitary-adrenal system with dexamethasone Life Sciences  1986 39:1281-1286  DOI:10.1016/0024-3205(86)90189-x  PMID:3489874
    • Downs, N. S., Britton, K. T., Gibbs, D. M., Koob, G. F., Swerdlow, N. R. Supersensitive endocrine response to physostigmine in dopamine-depleted rats - a model of depression Biological Psychiatry  1986 21:775-786  DOI:10.1016/0006-3223(86)90243-x  PMID:3015269
    • Swerdlow, N. R., Vaccarino, F. J., Amalric, M., Koob, G. F. The neural substrates for the motor-activating properties of psychostimulants - a review of recent findings Pharmacology, Biochemistry and Behavior  1986 25:233-248  DOI:10.1016/0091-3057(86)90261-3  PMID:2875470
    • Melia, K. F., Ehlers, C. L., Lebrun, C. J., Koob, G. F. Post-learning ethanol effects on a water-finding task in rats Pharmacology, Biochemistry and Behavior  1986 24:1813-1815  DOI:10.1016/0091-3057(86)90528-9  PMID:3737649
    • Britton, K. T., Lee, G., Vale, W., Rivier, J., Koob, G. F. Corticotropin releasing-factor (crf) receptor antagonist blocks activating and anxiogenic actions of crf in the rat Brain Research  1986 369:303-306  DOI:10.1016/0006-8993(86)90539-1  PMID:3008937
    • Koob, G. F., Dantzer, R., Bluthe, R. M., Lebrun, C., Bloom, F. E., Lemoal, M. Central injections of arginine vasopressin prolong extinction of active-avoidance Peptides  1986 7:213-218  DOI:10.1016/0196-9781(86)90215-9  PMID:3737445
    • Vaccarino, F. J., Amalric, M., Swerdlow, N. R., Koob, G. F. Blockade of amphetamine but not opiate-induced locomotion following antagonism of dopamine function in the rat Pharmacology, Biochemistry and Behavior  1986 24:61-65  DOI:10.1016/0091-3057(86)90045-6  PMID:3080760
    • Swerdlow, N. R., Braff, D. L., Geyer, M. A., Koob, G. F. Central dopamine hyperactivity in rats mimics abnormal acoustic startle response in schizophrenics Biological Psychiatry  1986 21:23-33  DOI:10.1016/0006-3223(86)90005-3  PMID:3080033
    • Swerdlow, N. R., Geyer, M. A., Vale, W. W., Koob, G. F. Corticotropin-releasing factor potentiates acoustic startle in rats - blockade by chlordiazepoxide Psychopharmacology  1986 88:147-152  DOI:10.1007/bf00652231  PMID:3081925
    • Deyo, S. N., Shoemaker, W. J., Ettenberg, A., Bloom, F. E., Koob, G. F. Subcutaneous administration of behaviorally effective doses of arginine vasopressin change brain avp content only in median-eminence Neuroendocrinology  1986 42:260-266  DOI:10.1159/000124449  PMID:3951675
    • Koob, G. F., Braestrup, C., Britton, K. T. The effects of fg-7142 and ro-15-1788 on the release of punished responding produced by chlordiazepoxide and ethanol in the rat Psychopharmacology  1986 90:173-178  PMID:3097697
    • Swerdlow, N. R., Koob, G. F., Aldenhoff, J. B. The effects of verapamil on the locomotor-activating properties of corticotropin releasing-factor (crf) in the rat Psychoneuroendocrinology  1986 11:237-240  DOI:10.1016/0306-4530(86)90059-4  PMID:34892
    • Vaccarino, F. J., Koob, G. F. Accumbens cholecystokinin attenuation of brain stimulation reward in the ventral tegmental area Annals of the New York Academy of Sciences  1985 448:669-670  DOI:10.1111/j.1749-6632.1985.tb29983.x
    • Koob, G. F., Lebrun, C., Martinez, J. L., Dantzer, R., Lemoal, M., Bloom, F. E. Arginine vasopressin, stress, and memory Annals of the New York Academy of Sciences  1985 444:194-202  DOI:10.1111/j.1749-6632.1985.tb37589.x  PMID:3860087
    • Vaccarino, F. J., Bloom, F. E., Koob, G. F. Blockade of nucleus accumbens opiate receptors attenuates intravenous heroin reward in the rat Psychopharmacology  1985 86:37-42  DOI:10.1007/bf00431681  PMID:2991967
    • Britton, K. T., Morgan, J., Rivier, J., Vale, W., Koob, G. F. Chlordiazepoxide attenuates response suppression induced by corticotropin-releasing factor in the conflict test Psychopharmacology  1985 86:170-174  DOI:10.1007/bf00431704  PMID:3927353
    • Koob, G. F., Bloom, F. E. Corticotropin-releasing factor and behavior Federation Proceedings  1985 44:259-263  PMID:3871412
    • Ehlers, C. L., Reed, T. K., Wang, M., Lebrun, C. J., Koob, G. F. EEG effects of subcutaneous and intracerebroventricular injections of arginine vasopressin in the rat Psychopharmacology  1985 87:430-433  DOI:10.1007/bf00432508  PMID:3936102
    • Swerdlow, N. R., Lee, D., Koob, G. F., Vaccarino, F. J. Effects of chronic dietary lithium on behavioral indexes of dopamine denervation supersensitivity in the rat Journal of Pharmacology and Experimental Therapeutics  1985 235:324-329  PMID:3932641
    • Eaves, M., Thatcherbritton, K., Rivier, J., Vale, W., Koob, G. F. Effects of corticotropin releasing-factor on locomotor-activity in hypophysectomized rats Peptides  1985 6:923-926  DOI:10.1016/0196-9781(85)90323-7  PMID:3878503
    • Vaccarino, F. J., Pettit, H. O., Bloom, F. E., Koob, G. F. Effects of intracerebroventricular administration of methyl naloxonium chloride on heroin self-administration in the rat Pharmacology, Biochemistry and Behavior  1985 23:495-498  DOI:10.1016/0091-3057(85)90027-9
    • Swerdlow, N. R., Vaccarino, F. J., Koob, G. F. Effects of naloxone on heroin-stimulated amphetamine-stimulated and caffeine-stimulated locomotor-activity in the rat Pharmacology, Biochemistry and Behavior  1985 23:499-501  DOI:10.1016/0091-3057(85)90028-0  PMID:4048244
    • Ehlers, C. L., Koob, G. F. Locomotor behavior following kindling in three different brain sites Brain Research  1985 326:71-79  DOI:10.1016/0006-8993(85)91385-x  PMID:3971150
    • Amalric, M., Koob, G. F. Low-doses of methylnaloxonium in the nucleus accumbens antagonize hyperactivity induced by heroin in the rat Pharmacology, Biochemistry and Behavior  1985 23:411-415  DOI:10.1016/0091-3057(85)90014-0  PMID:4048236
    • Koob, G. F., Dantzer, R., Rodriguez, F., Bloom, F. E., Lemoal, M. Osmotic-stress mimics effects of vasopressin on learned behavior Nature  1985 315:750-752  DOI:10.1038/315750a0  PMID:4010780
    • Swerdlow, N. R., Koob, G. F. Separate neural substrates of the locomotor-activating properties of amphetamine, heroin, caffeine and corticotropin releasing-factor (crf) in the rat Pharmacology, Biochemistry and Behavior  1985 23:303-307  DOI:10.1016/0091-3057(85)90574-x  PMID:3877311
    • Vaccarino, F. J., Bloom, F. E., Rivier, J., Vale, W., Koob, G. F. Stimulation of food-intake in rats by centrally administered hypothalamic growth hormone-releasing factor Nature  1985 314:167-168  DOI:10.1038/314167a0  PMID:3919314
    • Ehlers, C. L., Koob, G. F. The effects of chronic lithium on the EEG and locomotor response to drug challenge in rats Progress in Neuro-Psychopharmacology & Biological Psychiatry  1985 9:133-142  DOI:10.1016/0278-5846(85)90075-2  PMID:4001429
    • Lebrun, C., Lemoal, M., Koob, G. F., Bloom, F. E. Vasopressin pressor antagonist injected centrally reverses behavioral-effects of peripheral injection of vasopressin, but only at doses that reverse increase in blood-pressure Regulatory Peptides  1985 11:173-181  DOI:10.1016/0167-0115(85)90077-1  PMID:4035008
    • Lebrun, C. J., Rigter, H., Martinez, J. L., Koob, G. F., Lemoal, M., Bloom, F. E. Antagonism of effects of vasopressin (avp) on inhibitory avoidance by a vasopressin antagonist peptide dptyr(me)avp Life Sciences  1984 35:1505-1512  DOI:10.1016/0024-3205(84)90168-1  PMID:6482669
    • Lemoal, M., Dantzer, R., Mormede, P., Baduel, A., Lebrun, C., Ettenberg, A., Vanderkooy, D., Wenger, J., Deyo, S., Koob, G. F., Bloom, F. E. Behavioral-effects of peripheral administration of arginine vasopressin - a review of our search for a mode of action and a hypothesis Psychoneuroendocrinology  1984 9:319-341  DOI:10.1016/0306-4530(84)90042-8  PMID:6514931
    • Britton, D. R., Ksir, C., Britton, K. T., Young, D., Koob, G. F. Brain norepinephrine depleting lesions selectively enhance behavioral responsiveness to novelty Physiology & Behavior  1984 33:473-478  DOI:10.1016/0031-9384(84)90171-9  PMID:6440160
    • Astonjones, S., Astonjones, G., Koob, G. F. Cocaine antagonizes anxiolytic effects of ethanol Psychopharmacology  1984 84:28-31  DOI:10.1007/bf00432019  PMID:6149593
    • Moss, D. E., Koob, G. F., McMaster, S. B., Janowsky, D. S. Comparative effects of tetrahydrocannabinol on psychostimulant-induced behaviors Pharmacology, Biochemistry and Behavior  1984 21:641-644  PMID:6150497
    • Pettit, H. O., Ettenberg, A., Bloom, F. E., Koob, G. F. Destruction of dopamine in the nucleus accumbens selectively attenuates cocaine but not heroin self-administration in rats Psychopharmacology  1984 84:167-173  DOI:10.1007/bf00427441  PMID:6438676
    • Koob, G. F., Thatcherbritton, K., Britton, D. R., Roberts, D. C. S., Bloom, F. E. Destruction of the locus coeruleus or the dorsal ne bundle does not alter the release of punished responding by ethanol and chlordiazepoxide Physiology & Behavior  1984 33:479-485  DOI:10.1016/0031-9384(84)90172-0  PMID:6542682
    • Ettenberg, A., Koob, G. F. Different effects of cholecystokinin and satiety on lateral hypothalamic self-stimulation Physiology & Behavior  1984 32:127-130  DOI:10.1016/0031-9384(84)90083-0  PMID:6718524
    • Britton, K. T., Svensson, T., Schwartz, J., Bloom, F. E., Koob, G. F. Dorsal noradrenergic bundle lesions fail to alter opiate withdrawal or suppression of opiate withdrawal by clonidine Life Sciences  1984 34:133-139  DOI:10.1016/0024-3205(84)90583-6  PMID:6537983
    • Koob, G. F., Swerdlow, N., Seeligson, M., Eaves, M., Sutton, R., Rivier, J., Vale, W. Effects of alpha-flupenthixol and naloxone on crf-induced locomotor activation Neuroendocrinology  1984 39:459-464  DOI:10.1159/000124021  PMID:6096752
    • Koob, G. F., Pettit, H. O., Ettenberg, A., Bloom, F. E. Effects of opiate antagonists and their quaternary derivatives on heroin self-administration in the rat Journal of Pharmacology and Experimental Therapeutics  1984 229:481-486  PMID:6716270
    • Swerdlow, N. R., Swanson, L. W., Koob, G. F. Electrolytic lesions of the substantia innominata and lateral preoptic area attenuate the 'supersensitive' locomotor response to apomorphine resulting from denervation of the nucleus accumbens Brain Research  1984 306:141-148  DOI:10.1016/0006-8993(84)90362-7  PMID:6087974
    • Vaccarino, F. J., Koob, G. F. Microinjections of nanogram amounts of sulfated cholecystokinin octapeptide into the rat nucleus accumbens attenuates brain-stimulation reward Neuroscience Letters  1984 52:61-66  DOI:10.1016/0304-3940(84)90351-3  PMID:6098878
    • Koob, G. F., Simon, H., Herman, J. P., Lemoal, M. Neuroleptic-like disruption of the conditioned avoidance-response requires destruction of both the mesolimbic and nigrostriatal dopamine systems Brain Research  1984 303:319-329  DOI:10.1016/0006-8993(84)91218-6  PMID:6430466
    • Swerdlow, N. R., Koob, G. F. Restrained rats learn amphetamine-conditioned locomotion, but not place preference Psychopharmacology  1984 84:163-166  DOI:10.1007/bf00427440  PMID:6438675
    • Swerdlow, N. R., Swanson, L. W., Koob, G. F. Substantia innominata - critical link in the behavioral expression of mesolimbic dopamine stimulation in the rat Neuroscience Letters  1984 50:19-24  DOI:10.1016/0304-3940(84)90455-5  PMID:6493625
    • Swerdlow, N. R., Koob, G. F. The neural substrates of apomorphine-stimulated locomotor-activity following denervation of the nucleus accumbens Life Sciences  1984 35:2537-2544  DOI:10.1016/0024-3205(84)90440-5  PMID:6096659
    • Koob, G. F., Bloom, F. E. Behavioral effects of opioid peptides British Medical Bulletin  1983 39:89-94  PMID:6340789
    • Ettenberg, A., Vanderkooy, D., Lemoal, M., Koob, G. F., Bloom, F. E. Can aversive properties of (peripherally-injected) vasopressin account for its putative role in memory Behavioural Brain Research  1983 7:331-350  DOI:10.1016/0166-4328(83)90024-4  PMID:6838716
    • Vale, W., Rivier, C., Brown, M. R., Spiess, J., Koob, G., Swanson, L., Bilezikjian, L., Bloom, F., Rivier, J. Chemical and biological characterization of corticotropin releasing-factor Recent Progress in Hormone Research  1983 39:245-270  PMID:6314446
    • Swerdlow, N. R., Vanderkooy, D., Koob, G. F., Wenger, J. R. Cholecystokinin produces conditioned place-aversions, not place-preferences, in food-deprived rats - evidence against involvement in satiety Life Sciences  1983 32:2087-2093  DOI:10.1016/0024-3205(83)90096-6  PMID:6843283
    • Robbins, T. W., Roberts, D. C. S., Koob, G. F. Effects of d-amphetamine and apomorphine upon operant-behavior and schedule-induced licking in rats with 6-hydroxydopamine-induced lesions of the nucleus accumbens Journal of Pharmacology and Experimental Therapeutics  1983 224:662-673  PMID:6402587
    • Vanderkooy, D., Swerdlow, N. R., Koob, G. F. Paradoxical reinforcing properties of apomorphine - effects of nucleus accumbens and area postrema lesions Brain Research  1983 259:111-118  PMID:6824923
    • Ehlers, C. L., Indik, J. H., Koob, G. F., Bloom, F. E. The effect of single and repeated electroconvulsive shock (ECS) on locomotor-activity in rats Progress in Neuro-Psychopharmacology & Biological Psychiatry  1983 7:217-222  DOI:10.1016/0278-5846(83)90110-0  PMID:6684316
    • Ettenberg, A., Koob, G. F., Bloom, F. E. Time course of alpha-flupenthixol action explains response artifacts of neuroleptic action on brain-stimulation reward - reply Science  1983 222:1253-1254  DOI:10.1126/science.222.4629.1253-a
    • Ettenberg, A., Lemoal, M., Koob, G. F., Bloom, F. E. Vasopressin potentiation in the performance of a learned appetitive task - reversal by a pressor antagonist analog of vasopressin Pharmacology, Biochemistry and Behavior  1983 18:645-647  DOI:10.1016/0091-3057(83)90294-0  PMID:6867069
    • Strecker, R. E., Roberts, D. C. S., Koob, G. F. Apomorphine-induced facilitation of intra-cranical self-stimulation following dopamine denervation of the nucleus accumbens Pharmacology, Biochemistry and Behavior  1982 17:1015-1018  DOI:10.1016/0091-3057(82)90487-7  PMID:6817349
    • Koob, G. F., Bloom, F. E. Behavioral-effects of neuropeptides - endorphins and vasopressin Annual Review of Physiology  1982 44:571-582  DOI:10.1146/annurev.ph.44.030182.003035  PMID:7041806
    • Schwartz, J. M., Ksir, C., Koob, G. F., Bloom, F. E. Changes in locomotor response to beta-endorphin microinfusion during and after opiate abstinence syndrome - a proposal for a model of the onset of mania Psychiatry Research  1982 7:153-161  DOI:10.1016/0165-1781(92)90088-k  PMID:6292980
    • Sutton, R. E., Koob, G. F., Lemoal, M., Rivier, J., Vale, W. Corticotropin releasing-factor produces behavioral activation in rats Nature  1982 297:331-333  DOI:10.1038/297331a0  PMID:6978997
    • Roberts, D. C. S., Koob, G. F. Disruption of cocaine self-administration following 6-hydroxydopamine lesions of the ventral tegmental area in rats Pharmacology, Biochemistry and Behavior  1982 17:901-904  DOI:10.1016/0091-3057(82)90469-5  PMID:6817350
    • Staunton, D. A., Magistretti, P. J., Koob, G. F., Shoemaker, W. J., Bloom, F. E. Dopaminergic super-sensitivity induced by denervation and chronic receptor blockade is additive Nature  1982 299:72-74  DOI:10.1038/299072a0  PMID:7110328
    • Ettenberg, A., Pettit, H. O., Bloom, F. E., Koob, G. F. Heroin and cocaine intravenous self-administration in rats - mediation by separate neural systems Psychopharmacology  1982 78:204-209  DOI:10.1007/bf00428151  PMID:6296898
    • Britton, D. R., Koob, G. F., Rivier, J., Vale, W. Intraventricular corticotropin-releasing factor enhances behavioral-effects of novelty Life Sciences  1982 31:363-367  DOI:10.1016/0024-3205(82)90416-7  PMID:6983018
    • Ehlers, C. L., Koob, G. F., Bloom, F. E. Post-ictal locomotor-activity in 3 different rat models of epilepsy Brain Research  1982 250:178-182  DOI:10.1016/0006-8993(82)90966-0  PMID:7139314
    • Fray, P. J., Koob, G. F., Iversen, S. D. Tail-pinch-elicited behavior in rats - preference, plasticity, and learning Behavioral and Neural Biology  1982 36:108-125  DOI:10.1016/s0163-1047(82)90112-1  PMID:7183308
    • Koob, G. F. The dopamine anhedonia hypothesis - a pharmacological phrenology Behavioral and Brain Sciences  1982 5:63-64
    • Joyce, E. M., Koob, G. F. Amphetamine-induced, scopolamine-induced and caffeine-induced locomotor-activity following 6-hydroxydopamine lesions of the mesolimbic dopamine system Psychopharmacology  1981 73:311-313  DOI:10.1007/bf00426456  PMID:6789349
    • Koob, G. F., Lemoal, M., Gaffori, O., Manning, M., Sawyer, W. H., Rivier, J., Bloom, F. E. Arginine vasopressin and a vasopressin antagonist peptide - opposite effects on extinction of active-avoidance in rats Regulatory Peptides  1981 2:153-163  DOI:10.1016/0167-0115(81)90009-4  PMID:7255768
    • Ettenberg, A., Rogers, J., Koob, G. F., Bloom, F. E. Endogenous opiates and fasting Science  1981 213:1282-1282  DOI:10.1126/science.6267697  PMID:6267697
    • Koob, G. F., Stinus, L., Lemoal, M. Hyperactivity and hypoactivity produced by lesions to the mesolimbic dopamine system Behavioural Brain Research  1981 3:341-359  DOI:10.1016/0166-4328(81)90004-8  PMID:6796098
    • Ettenberg, A., Koob, G. F., Bloom, F. E. Response artifact in the measurement of neuroleptic-induced anhedonia Science  1981 213:357-359  DOI:10.1126/science.7244622  PMID:7244622
    • Joyce, E. M., Koob, G. F., Strecker, R., Iversen, S. D., Bloom, F. E. The behavioral-effects of enkephalin analogs injected into the ventral tegmental area and globus pallidus Brain Research  1981 221:359-370  DOI:10.1016/0006-8993(81)90784-8  PMID:7025963
    • Lemoal, M., Koob, G. F., Koda, L. Y., Bloom, F. E., Manning, M., Sawyer, W. H., Rivier, J. Vasopressor receptor antagonist prevents behavioral-effects of vasopressin Nature  1981 291:491-493  PMID:7231561
    • Fray, P. J., Sahakian, B. J., Robbins, T. W., Koob, G. F., Iversen, S. D. An observational method for quantifying the behavioral-effects of dopamine agonists - contrasting effects of d-amphetamine and apomorphine Psychopharmacology  1980 69:253-259  DOI:10.1007/bf00433091  PMID:6774363
    • Sessions, G. R., Meyerhoff, J. L., Kant, G. J., Koob, G. F. Effects of lesions of the ventral medial tegmentum on locomotor-activity, biogenic-amines and response to amphetamine in rats Pharmacology, Biochemistry and Behavior  1980 12:603-608  PMID:7393956
    • Roberts, D. C. S., Koob, G. F., Klonoff, P., Fibiger, H. C. Extinction and recovery of cocaine self-administration following 6-hydroxydopamine lesions of the nucleus accumbens Pharmacology, Biochemistry and Behavior  1980 12:781-787  DOI:10.1016/0091-3057(80)90166-5  PMID:7393973
    • Stinus, L., Koob, G. F., Ling, N., Bloom, F. E., Lemoal, M. Locomotor activation induced by infusion of endorphins into the ventral tegmental area - evidence for opiate-dopamine interactions Proceedings of the National Academy of Sciences of the United States of America-Biological Sciences  1980 77:2323-2327  DOI:10.1073/pnas.77.4.2323  PMID:6929553
    • Robbins, T. W., Koob, G. F. Selective disruption of displacement behavior by lesions of the mesolimbic dopamine system Nature  1980 285:409-412  DOI:10.1038/285409a0  PMID:6104303
    • Lemoal, M., Koob, G. F., Bloom, F. E. Endorphins and extinction - differential actions on appetitive and adversive tasks Life Sciences  1979 24:1631-1636  DOI:10.1016/0024-3205(79)90245-5  PMID:481097
    • Koob, G. F., Riley, S. J., Smith, S. C., Robbins, T. W. Effects of 6-hydroxydopamine lesions of nucleus accumbens septi and olfactory tubercle on feeding, locomotor-activity, and amphetamine anorexia in rat Journal of Comparative and Physiological Psychology  1978 92:917-927  DOI:10.1037/h0077542  PMID:282297
    • Koob, G. F., Kelley, A. E., Mason, S. T. Locus coeruleus lesions - learning and extinction Physiology & Behavior  1978 20:709-716  DOI:10.1016/0031-9384(78)90296-2  PMID:684108
    • Emson, P. C., Koob, G. F. Origin and distribution of dopamine-containing afferents to rat frontal cortex Brain Research  1978 142:249-267  DOI:10.1016/0006-8993(78)90634-0  PMID:24492
    • Robbins, T. W., Koob, G. F. Pipradrol enhances reinforcing properties of stimuli paired with brain-stimulation Pharmacology, Biochemistry and Behavior  1978 8:219-222  DOI:10.1016/0091-3057(78)90308-8  PMID:26063
    • Sahakian, B. J., Koob, G. F. Relationship between pipradrol-induced responding for electrical brain-stimulation, stereotyped behavior and locomotor-activity Neuropharmacology  1978 17:363-366  DOI:10.1016/0028-3908(78)90007-2  PMID:27732
    • Koob, G. F., Fray, P. J., Iversen, S. D. Self-stimulation at lateral hypothalamus and locus coeruleus after specific unilateral lesions of dopamine system Brain Research  1978 146:123-140  DOI:10.1016/0006-8993(78)90222-6  PMID:647383
    • Koob, G. F., Delfiacco, M., Iversen, S. D. Spontaneous and amphetamine-induced behavior after bilateral injection of ethanolamine-o-sulfate into substantia nigra Brain Research  1978 146:313-323  DOI:10.1016/0006-8993(78)90976-9  PMID:565665
    • Koda, L. Y., Koob, G. F., Shier, W. T., Bloom, F. E. Tetrahydropapaveroline induces small granular vesicles in brain dopamine fibers Nature  1978 276:281-283  DOI:10.1038/276281a0  PMID:714160
    • Koob, G. F., Winger, G. D., Meyerhoff, J. L., Annau, Z. Effects of d-amphetamine on concurrent self-stimulation of forebrain and brain-stem loci Brain Research  1977 137:109-126  DOI:10.1016/0006-8993(77)91015-0  PMID:303535
    • Koob, G. F. Incentive shifts in intracranial self-stimulation produced by different series of stimulus-intensity presentations Physiology & Behavior  1977 18:131-135  DOI:10.1016/0031-9384(77)90104-4  PMID:410045
    • Koob, G. F., Sessions, G. R., Kant, G. J., Meyerhoff, J. L. Dissociation of hyperdipsia from destruction of locus coeruleus in rats Brain Research  1976 116:339-345  DOI:10.1016/0006-8993(76)90914-8  PMID:974779
    • Koob, G. F., Balcom, G. J., Meyerhoff, J. L. Increases in intracranial self-stimulation in posterior hypothalamus following unilateral lesions in locus coeruleus Brain Research  1976 101:554-560  DOI:10.1016/0006-8993(76)90478-9  PMID:942689
    • Sessions, G. R., Kant, G. J., Koob, G. F. Locus coeruleus lesions and learning in rat Physiology & Behavior  1976 17:853-859  DOI:10.1016/0031-9384(76)90053-6  PMID:1026995
    • Koob, G. F., Fray, P. J., Iversen, S. D. Tail-pinch stimulation - sufficient motivation for learning Science  1976 194:637-639  DOI:10.1126/science.982032  PMID:982032
    • Koob, G. F., Balcom, G. J., Meyerhoff, J. L. Dopamine and norepinephrine levels in nucleus accumbens, olfactory tubercle and corpus striatum following lesions in ventral tegmental area Brain Research  1975 94:45-55  DOI:10.1016/0006-8993(75)90875-6  PMID:1148866
    • Koob, G. F., Spector, N. H., Meyerhoff, J. L. Effects of heroin on lever pressing for intracranial self-stimulation, food and water in rat Psychopharmacologia  1975 42:231-234  DOI:10.1007/bf00421261  PMID:1161980
    • Koob, G. F., Annau, Z. Behavioral and neurochemical alterations induced by hypoxia in rats American Journal of Physiology  1974 227:73-78  PMID:4843358
    • Koob, G. F., Annau, Z., Rubin, R. J., Montgomery, M. R. Effect of hypoxic hypoxia and carbon monoxide on food intake, water intake, and body weight in two strains of rats Life Sciences  1974 14:1511-1520  DOI:10.1016/0024-3205(74)90162-3  PMID:4829542
    • Annau, Z., Heffner, R., Koob, G. F. Electrical self-stimulation of single and multiple loci - long-term observations Physiology & Behavior  1974 13:281-290  DOI:10.1016/0031-9384(74)90046-8  PMID:4413200
    • Koob, G. F., Annau, Z. Effect of hypoxia on hypothalamic mechanisms American Journal of Physiology  1973 224:1403-1408  PMID:4576261
  • chapter

    • Koob, G. F., Le Moal, M. Addiction and the brain antireward system Annual Review of Psychology. 29-53. 2008  DOI:10.1146/annurev.psych.59.103006.093548
    • Amalric, M., Koob, G. F. Functionally selective neurochemical afferents and efferents of the mesocorticolimbic and nigrostriatal dopamine system Chemical signalling in the basal ganglia. 209-226. 1993
  • thesis

    • Effects of hypoxia on hypothalamic mechanisms 1972

featured in

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  • New International Agreement Advances Scripps Research Study of Alcoholism  News Release
  • Scripps Research Institute Study Suggests Intermittent Binge Drinking Could Cause Significant Brain Impairment Within Months  News Release
  • Scripps Research Team Finds Stress Hormone Key to Alcohol Dependence  News Release
  • View from a Zeppelin: Interview with George Koob   Newsletter
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Affiliation

head of

  • Committee on the Neurobiology of Addictive Disorders (CNAD) 2006 - 2014
  • Pearson Center for Alcohol and Addiction Research Co-Director 2003 - 2014
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Research

research overview

  • Dr. Koob's  early research interests were directed at the neurobiology of emotion, with a focus on the theoretical constructs of reward and stress. He has made contributions to our understanding of the anatomical connections of the emotional systems and the neurochemistry of emotional function. Dr. Koob has identified afferent and efferent connections of the basal forebrain in the region of the nucleus accumbens, bed nucleus of the stria terminalis, and central nucleus of the amygdala in motor activation, reinforcement mechanisms, behavioral responses to stress, drug self-administration, and the neuroadaptation associated with drug dependence. Dr. Koob's work with the neurobiology of stress includes the characterization of behavioral functions in the central nervous system for catecholamines, opioid peptides, and corticotropin-releasing factor. Corticotropin-releasing factor, in addition to its classical hormonal functions in the hypothalamic-pituitary-adrenal axis, is also located in extrahypothalamic brain structures and may have an important role in brain emotional function. Recent use of specific corticotropin-releasing factor antagonists suggests that endogenous brain corticotropin-releasing factor may be involved in specific behavioral responses to stress, the psychopathology of anxiety and affective disorders, and drug addiction. Dr. Koob also has characterized functional roles for other stress-related neurotransmitters/neuroregulators such as norepinephrine, vasopressin, hypocretin (orexin), neuropeptide Y, and neuroactive steroids.

    Dr. Koob also is one of the world’s authorities on the neurobiology of drug addiction. He has contributed to our understanding of the neurocircuitry associated with the acute reinforcing effects of drugs of abuse and more recently on the neuroadaptations of these reward circuits associated with the transition to dependence. He has validated key animal models for dependence associated with drugs of abuse and has begun to explore a key role of anti-reward systems in the development of dependence. The identification of specific neurochemical systems within the basal forebrain system of the extended amygdala involved in motivation has significant theoretical and heuristic impact. From a theoretical perspective, identification of a role for dopaminergic, opioidergic, GABAergic, glutamatergic and corticotropin-releasing factor systems in the excessive drug taking provides a neuropharmacologic basis for the allostatic changes hypothesized to drive the process of pathology associated with addiction, anxiety, and depression. From a heuristic perspective, these findings provide a framework for further molecular, cellular and neurocircuit research that will identify the basis for individual differences in vulnerability to pathology.

    Future research plans

    Future research is focused on understanding the neurobiological bases for altered motivational states associated with drug addiction at the neurocircuitry, cellular and molecular level and using these studies as a heuristic approach to the study of emotions. The ultimate goal is to understand how cellular and molecular changes produce changes in particular neurocircuits to convey negative emotional states that contribute to the motivation to seek drugs, but also contribute to other disorders of motivation in psychopathology. In addition, the laboratory will be exploring the relationship between pain and emotional systems in the context of the same neurocircuitry. The neurocircuitry under study involves specific elements of the basal forebrain involving the central nucleus of the amygdala, bed nucleus of the stria terminalis and elements of the ventral striatum including the shell and core of the nucleus accumbens. Neuropeptides of the brain stress systems outside of the hypothalamic-pituitary-adrenal system are hypothesized to have a key role in mediating changes in emotional state and include corticotropin releasing factor, dynorphin, vasopressin, substance P,  orexin and neuropeptide Y and nociceptin. Future studies will include identification of molecular factors that load such circuits and neurotransmitter system function, identification of cellular interactions between such brain stress systems and identification of the role of outputs such as the hypothalamus in expressing such negative emotional states. Such research will provide key information not only about the neurobiology of addiction, pain and stress but also key information about the neurobiology of motivational systems in general.

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Background

education and training

  • Ph.D. in Behavioral Psychology, Johns Hopkins University 1972
  • B.S. in Zoology, Johns Hopkins University 1969

awards and honors

  • Chevalier de la Légion d’honneur (Knight of the Legion of Honor), conferred by France, 2016
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Contact

full name

  • George F. Koob

geographic location

  • Scripps California 

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