recent publications
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academic article
- Ray, L. A., Grodin, E. N., Leggio, L., Bechtholt, A. J., Becker, H., Ewing, S. F. W., Jentsch, J. D., King, A. C., Mason, B. J., O'Malley, S., MacKillop, J., Heilig, M., et al. The future of translational research on alcohol use disorder Addiction Biology 2020 DOI:10.1111/adb.12903 PMID:32286721
- Xu, J., Ma, H. Y., Liu, X., Rosenthal, S., Baglieri, J., McCubbin, R., Sun, M., Koyama, Y., Geoffroy, C. G., Saijo, K., Shang, L., Nishio, T., et al. Blockade of IL-17 signaling reverses alcohol-induced liver injury and excessive alcohol drinking in mice Jci Insight 2020 5 DOI:10.1172/jci.insight.131277 PMID:32051339 PMCID:PMC7098802
- Tunstall, B. J., Lorrai, I., McConnell, S. A., Gazo, K. L., Zeller, L. J., de Guglielmo, G., Hoang, I., Haass-Koffler, C. L., Repunte-Canonigo, V., Koob, G. F., Vendruscolo, L. F., Sanna, P. P. Probenecid reduces alcohol drinking in rodents. is pannexin1 a novel therapeutic target for alcohol use disorder? Alcohol and Alcoholism 2019 54:497-502 DOI:10.1093/alcalc/agz054 PMID:31535696 PMCID:PMC6751410
- Zorrilla, E. P., Koob, G. F. Impulsivity derived from the dark side: neurocircuits that contribute to negative urgency Frontiers in Behavioral Neuroscience 2019 13 DOI:10.3389/fnbeh.2019.00136 PMID:31293401 PMCID:PMC6603097
- Tunstall, B. J., Kirson, D., Zallar, L. J., McConnell, S. A., Vendruscolo, J. C. M., Ho, C. P., Oleata, C. S., Khom, S., Manning, M., Lee, M. R., Leggio, L., Koob, G. F., et al. Oxytocin blocks enhanced motivation for alcohol in alcohol dependence and blocks alcohol effects on GABAergic transmission in the central amygdala PLoS Biology 2019 17 DOI:10.1371/journal.pbio.2006421 PMID:30990816 PMCID:PMC6467366
- de Guglielmo, G., Kallupi, M., Pomrenze, M. B., Crawford, E., Simpson, S., Schweitzer, P., Koob, G. F., Messing, R. O., George, O. Inactivation of a CRF-dependent amygdalofugal pathway reverses addiction-like behaviors in alcohol-dependent rats Nature Communications 2019 10 DOI:10.1038/s41467-019-09183-0 PMID:30886240 PMCID:PMC6423296
- Pelloux, Y., Degoulet, M., Tiran-Cappello, A., Cohen, C., Lardeux, S., George, O., Koob, G. F., Ahmed, S. H., Baunez, C. Subthalamic nucleus high frequency stimulation prevents and reverses escalated cocaine use Molecular Psychiatry 2018 23:2266-2276 DOI:10.1038/s41380-018-0080-y PMID:29880881
- Schmeichel, B. E., Matzeu, A., Koebel, P., Vendruscolo, L. F., Sidhu, H., Shahryari, R., Kieffer, B. L., Koob, G. F., Martin-Fardon, R., Contet, C. Knockdown of hypocretin attenuates extended access of cocaine self-administration in rats Neuropsychopharmacology 2018 43:2373-2382 DOI:10.1038/s41386-018-0054-4 PMID:29703996 PMCID:PMC6180106
- Frantz, K., Roberto, M., Mason, B., Koob, G. F., Volkow, N., de Fonseca, F. R. Larry Parsons: Researcher, mentor, and friend Addiction Biology 2018 23:1204-1206 DOI:10.1111/adb.12686 PMID:30485629
- Verheij, M. M. M., Contet, C., Karel, P., Latour, J., van der Doelen, R. H. A., Geenen, B., van Hulten, J. A., Meyer, F., Kozicz, T., George, O., Koob, G. F., Homberg, J. R. Median and dorsal raphe serotonergic neurons control moderate versus compulsive cocaine intake Biological Psychiatry 2018 83:1024-1035 DOI:10.1016/j.biopsych.2017.10.031 PMID:29357981 PMCID:PMC5960600
- Aoun, E. G., Jimenez, V. A., Vendruscolo, L. F., Walter, N. A. R., Barbier, E., Ferrulli, A., Haass-Koffler, C. L., Darakjian, P., Lee, M. R., Addolorato, G., Heilig, M., Hitzemann, R., et al. A relationship between the aldosterone-mineralocorticoid receptor pathway and alcohol drinking: preliminary translational findings across rats, monkeys and humans Molecular Psychiatry 2018 23:1466-1473 DOI:10.1038/mp.2017.97 PMID:28461696 PMCID:PMC5668213
- Kenny, P. J., Hoyer, D., Koob, G. F. Animal models of addiction and neuropsychiatric disorders and their role in drug discovery: honoring the legacy of Athina Markou Biological Psychiatry 2018 83:940-946 DOI:10.1016/j.biopsych.2018.02.009 PMID:29602521
- Vendruscolo, J. C. M., Tunstall, B. J., Carmack, S. A., Schmeichel, B. E., Lowery-Gionta, E. G., Cole, M., George, O., Vandewater, S. A., Taffe, M. A., Koob, G. F., Vendruscolo, L. F. Compulsive-like sufentanil vapor self-administration in rats Neuropsychopharmacology 2018 43:801-809 DOI:10.1038/npp.2017.172 PMID:28812595 PMCID:PMC5809787
- Logrip, M. L., Walker, J. R., Ayanwuyi, L. O., Sabino, V., Ciccocioppo, R., Koob, G. F., Zorrilla, E. P. Evaluation of alcohol preference and drinking in msP rats bearing a Crhr1 promoter polymorphism Frontiers in Psychiatry 2018 9 DOI:10.3389/fpsyt.2018.00028
- Tian, Y. H., Ma, S. X., Lee, K. W., Wee, S., Koob, G. F., Lee, S. Y., Jang, C. G. Blockade of TRPV1 inhibits methamphetamine-induced rewarding effects Scientific Reports 2018 8 DOI:10.1038/s41598-018-19207-2 PMID:29343767 PMCID:PMC5772440
- Francesconi, W., Szucs, A., Berton, F., Koob, G. F., Vendruscolo, L. F., Sanna, P. P. Opiate dependence induces cell type-specific plasticity of intrinsic membrane properties in the rat juxtacapsular bed nucleus of stria terminalis (jcBNST) Psychopharmacology 2017 234:3485-3498 DOI:10.1007/s00213-017-4732-4 PMID:28986608
- George, O., Koob, G. F. Individual differences in the neuropsychopathology of addiction Dialogues in Clinical Neuroscience 2017 19:217-229
- Wade, C. L., Kallupi, M., Hernandez, D. O., Breysse, E., de Guglielmo, G., Crawford, E., Koob, G. F., Schweitzer, P., Baunez, C., George, O. High-frequency stimulation of the subthalamic nucleus blocks compulsive-like re-escalation of heroin taking in rats Neuropsychopharmacology 2017 42:1850-1859 DOI:10.1038/npp.2016.270 PMID:27917870
- Schmeichel, B. E., Herman, M. A., Roberto, M., Koob, G. F. Hypocretin neurotransmission within the central amygdala mediates escalated cocaine self-administration and stress-induced reinstatement in rats Biological Psychiatry 2017 81:606-615 DOI:10.1016/j.biopsych.2016.06.010 PMID:27567312 PMCID:PMC5161745
- Koob, G. F. The dark side of addiction: The Horsley Gantt to Joseph Brady connection Journal of Nervous and Mental Disease 2017 205:270-272 DOI:10.1097/nmd.0000000000000551 PMID:27356121
- Harris, R. A., Bajo, M., Bell, R. L., Blednov, Y. A., Varodayan, F. P., Truitt, J. M., de Guglielmo, G., Lasek, A. W., Logrip, M. L., Vendruscolo, L. F. Genetic and Pharmacologic Manipulation of TLR4 Has Minimal Impact on Ethanol Consumption in Rodents Journal of Neuroscience 2017 37:1139-1155 DOI:10.1523/jneurosci.2002-16.2016 PMID:27986929 PMCID:PMC5296793
- Galinato, M. H., Lockner, J. W., Fannon-Pavlich, M. J., Sobieraj, J. C., Staples, M. C., Somkuwar, S. S., Ghofranian, A., Chaing, S., Navarro, A. I., Joea, A., Luikart, B. W., Janda, K. D., et al. A synthetic small-molecule Isoxazole-9 protects against methamphetamine relapse Molecular Psychiatry 2017 23:629-638 DOI:10.1038/mp.2017.46 PMID:28348387 PMCID:PMC5617764
- de Guglielmo, G., Crawford, E., Kim, S., Vendruscolo, L. F., Hope, B. T., Brennan, M., Cole, M., Koob, G. F., George, O. Recruitment of a neuronal ensemble in the central nucleus of the amygdala is required for alcohol dependence Journal of Neuroscience 2016 36:9446-9453 DOI:10.1523/jneurosci.1395-16.2016 PMID:27605618 PMCID:PMC5013191
- Verheij, M. M. M., Vendruscolo, L. F., Caffino, L., Giannotti, G., Cazorla, M., Fumagalli, F., Riva, M. A., Homberg, J. R., Koob, G. F., Contet, C. Systemic Delivery of a Brain-Penetrant TrkB Antagonist Reduces Cocaine Self-Administration and Normalizes TrkB Signaling in the Nucleus Accumbens and Prefrontal Cortex Journal of Neuroscience 2016 36:8149-8159 DOI:10.1523/jneurosci.2711-14.2016 PMID:27488635 PMCID:PMC4971362
- Koob, G. F., Volkow, N. D. Neurobiology of addiction: a neurocircuitry analysis Lancet Psychiatry 2016 3:760-773 PMID:27475769
- You, I. J., Wright, S. R., Garcia-Garcia, A. L., Tapper, A. R., Gardner, P. D., Koob, G. F., Leonardo, E. D., Bohn, L. M., Wee, S. 5-HT1A autoreceptors in the dorsal raphe nucleus convey vulnerability to compulsive cocaine seeking Neuropsychopharmacology 2016 41:1210-1222 DOI:10.1038/npp.2015.268 PMID:26324408 PMCID:PMC4793105
- Collins, F. S., Anderson, J. M., Austin, C. P., Battey, J. F., Birnbaum, L. S., Briggs, J. P., Clayton, J. A., Cuthbert, B., Eisinger, R. W., Fauci, A. S., Gallin, J. I., Gibbons, G. H., et al. Basic science: Bedrock of progress Science 2016 351:1405-1405 PMID:27013720 PMCID:PMC5101936
- Sanna, P. P., Kawamura, T., Chen, J., Koob, G. F., Roberts, A. J., Vendruscolo, L. F., Repunte-Canonigo, V. 11β-hydroxysteroid dehydrogenase inhibition as a new potential therapeutic target for alcohol abuse Translational Psychiatry 2016 6 DOI:10.1038/tp.2016.13 PMID:26978742 PMCID:PMC4872439
- Koob, G. F., Mason, B. J. Existing and future drugs for the treatment of the dark side of addiction Annual Review of Pharmacology and Toxicology 2016 56:299-322 DOI:10.1146/annurev-pharmtox-010715-103143 PMID:26514207
- Saba, L. M., Flink, S. C., Vanderlinden, L. A., Israel, Y., Tampier, L., Colombo, G., Kiianmaa, K., Bell, R. L., Printz, M. P., Flodman, P., Koob, G., Richardson, H. N., et al. The sequenced rat brain transcriptome - its use in identifying networks predisposing alcohol consumption FEBS Journal 2015 282:3556-3578 DOI:10.1111/febs.13358 PMID:26183165 PMCID:PMC4573833
- Volkow, N. D., Koob, G. Brain disease model of addiction: why is it so controversial? Lancet Psychiatry 2015 2:677-679 PMID:26249284 PMCID:PMC4556943
- Cui, C., Noronha, A., Warren, K. R., Koob, G. F., Sinha, R., Thakkar, M., Matochik, J., Crews, F. T., Chandler, L. J., Pfefferbaum, A., Becker, H. C., Lovinger, D., et al. Brain pathways to recovery from alcohol dependence Alcohol 2015 49:435-452 DOI:10.1016/j.alcohol.2015.04.006 PMID:26074423 PMCID:PMC4468789
- Vendruscolo, L. F., Estey, D., Goodell, V., Macshane, L. G., Logrip, M. L., Schlosburg, J. E., McGinn, M. A., Zamora-Martinez, E. R., Belanoff, J. K., Hunt, H. J., Sanna, P. P., George, O., et al. Glucocorticoid receptor antagonism decreases alcohol seeking in alcohol-dependent individuals Journal of Clinical Investigation 2015 125:3193-3197 DOI:10.1172/jci79828 PMID:26121746
- Schmeichel, B. E., Barbier, E., Misra, K. K., Contet, C., Schlosburg, J. E., Grigoriadis, D., Williams, J. P., Karlsson, C., Pitcairn, C., Heilig, M., Koob, G. F., Vendruscolo, L. F. Hypocretin receptor 2 antagonism dose-dependently reduces escalated heroin self-administration in rats Neuropsychopharmacology 2015 40:1123-1129 DOI:10.1038/npp.2014.293 PMID:25367502 PMCID:PMC4367454
- Park, P. E., Schlosburg, J. E., Vendruscolo, L. F., Schulteis, G., Edwards, S., Koob, G. F. Chronic CRF1 receptor blockade reduces heroin intake escalation and dependence-induced hyperalgesia Addiction Biology 2015 20:275-284 DOI:10.1111/adb.12120 PMID:24330252 PMCID:PMC4057367
- Leao, R. M., Cruz, F. C., Vendruscolo, L. F., de Guglielmo, G., Logrip, M. L., Planeta, C. S., Hope, B. T., Koob, G. F., George, O. Chronic nicotine activates stress/reward-related brain regions and facilitates the transition to compulsive alcohol drinking Journal of Neuroscience 2015 35:6241-6253 DOI:10.1523/jneurosci.3302-14.2015 PMID:25878294
- Wade, C. L., Vendruscolo, L. F., Schlosburg, J. E., Hernandez, D. O., Koob, G. F. Compulsive-like responding for opioid analgesics in rats with extended access Neuropsychopharmacology 2015 40:421-428 DOI:10.1038/npp.2014.188 PMID:25060491 PMCID:PMC4443956
- Cohen, A., Soleiman, M. T., Talia, R., Koob, G. F., George, O., Mandyam, C. D. Extended access nicotine self-administration with periodic deprivation increases immature neurons in the hippocampus Psychopharmacology 2015 232:453-463 DOI:10.1007/s00213-014-3685-0 PMID:25059540 PMCID:PMC4297709
- Cohen, A., Treweek, J., Edwards, S., Leao, R. M., Schulteis, G., Koob, G. F., George, O. Extended access to nicotine leads to a CRF1 receptor dependent increase in anxiety-like behavior and hyperalgesia in rats Addiction Biology 2015 20:56-68 DOI:10.1111/adb.12077 PMID:23869743 PMCID:PMC3859819
- Whitfield Jr., T. W., Schlosburg, J. E., Wee, S., Gould, A., George, O., Grant, Y., Zamora-Martinez, E. R., Edwards, S., Crawford, E., Vendruscolo, L. F., Koob, G. F. κ Opioid receptors in the nucleus accumbens shell mediate escalation of methamphetamine intake Journal of Neuroscience 2015 35:4296-4305 DOI:10.1523/jneurosci.1978-13.2015 PMID:25762676 PMCID:PMC4355200
- Grieder, T. E., Herman, M. A., Contet, C., Tan, L. A., Vargas-Perez, H., Cohen, A., Chwalek, M., Maal-Bared, G., Freiling, J., Schlosburg, J. E., Clarke, L., Crawford, E., et al. VTA CRF neurons mediate the aversive effects of nicotine withdrawal and promote intake escalation Nature Neuroscience 2014 17:1751-1758 DOI:10.1038/nn.3872 PMID:25402857 PMCID:PMC4241147
- George, O., Koob, G. F., Vendruscolo, L. F. Negative reinforcement via motivational withdrawal is the driving force behind the transition to addiction Psychopharmacology 2014 231:3911-3917 DOI:10.1007/s00213-014-3623-1 PMID:24923982
- Buck, C. L., Malavar, J. C., George, O., Koob, G. F., Vendruscolo, L. F. Anticipatory 50 kHz ultrasonic vocalizations are associated with escalated alcohol intake in dependent rats Behavioural Brain Research 2014 271:171-176 DOI:10.1016/j.bbr.2014.06.003 PMID:24914463 PMCID:PMC4216724
- Repunte-Canonigo, V., Lefebvre, C., George, O., Kawamura, T., Morales, M., Koob, G. F., Califano, A., Masliah, E., Sanna, P. P. Gene expression changes consistent with neuroAIDS and impaired working memory in HIV-1 transgenic rats Molecular Neurodegeneration 2014 9:26 DOI:10.1186/1750-1326-9-26 PMID:24980976 PMCID:PMC4107468
- Deschaux, O., Vendruscolo, L. F., Schlosburg, J. E., Diaz-Aguilar, L., Yuan, C. J., Sobieraj, J. C., George, O., Koob, G. F., Mandyam, C. D. Hippocampal neurogenesis protects against cocaine-primed relapse Addiction Biology 2014 19:562-574 DOI:10.1111/adb.12019 PMID:23278919 PMCID:PMC3620729
- Vanderlinden, L. A., Saba, L. M., Printz, M. P., Flodman, P., Koob, G., Richardson, H. N., Hoffman, P. L., Tabakoff, B. Is the alcohol deprivation effect genetically mediated? Studies with HXB/BXH recombinant inbred rat strains Alcoholism-Clinical and Experimental Research 2014 38:2148-2157 DOI:10.1111/acer.12471 PMID:24961585 PMCID:PMC4142977
- Logrip, M. L., Vendruscolo, L. F., Schlosburg, J. E., Koob, G. F., Zorrilla, E. P. Phosphodiesterase 10A regulates alcohol and saccharin self-administration in rats Neuropsychopharmacology 2014 39:1722-1731 DOI:10.1038/npp.2014.20 PMID:24549104 PMCID:PMC4023146
- Cohen, A., Whitfield, T. W., Kreifeldt, M., Koebel, P., Kieffer, B. L., Contet, C., George, O., Koob, G. F. Virus-mediated shRNA knockdown of prodynorphin in the rat nucleus accumbens attenuates depression-like behavior and cocaine locomotor sensitization PLoS One 2014 9:e97216 DOI:10.1371/journal.pone.0097216 PMID:24816773 PMCID:PMC4016270
- Mazei-Robison, M. S., Appasani, R., Edwards, S., Wee, S., Taylor, S. R., Picciotto, M. R., Koob, G. F., Nestler, E. J. Self-administration of ethanol, cocaine, or nicotine does not decrease the soma size of ventral tegmental area dopamine neurons PLoS One 2014 9:e95962 DOI:10.1371/journal.pone.0095962 PMID:24755634 PMCID:PMC3995955
- Zorrilla, E. P., Logrip, M. L., Koob, G. F. Corticotropin releasing factor: a key role in the neurobiology of addiction Frontiers in Neuroendocrinology 2014 35:234-244 DOI:10.1016/j.yfrne.2014.01.001 PMID:24456850 PMCID:PMC4213066
- Buck, C. L., Vendruscolo, L. F., Koob, G. F., George, O. Dopamine D1 and mu-opioid receptor antagonism blocks anticipatory 50 kHz ultrasonic vocalizations induced by palatable food cues in Wistar rats Psychopharmacology 2014 231:929-937 DOI:10.1007/s00213-013-3307-2 PMID:24221826 PMCID:PMC3945412
- Hicks, M. J., Kaminsky, S. M., De, B. P., Rosenberg, J. B., Evans, S. M., Foltin, R. W., Andrenyak, D. M., Moody, D. E., Koob, G. F., Janda, K. D., Arbona, R. J. R., Lepherd, M. L., et al. Fate of systemically administered cocaine in nonhuman primates treated with the dAd5GNE anticocaine vaccine Human Gene Therapy Clinical Development 2014 25:40-49 DOI:10.1089/humc.2013.231 PMID:24649839 PMCID:PMC4047994
- Gilpin, N. W., Roberto, M., Koob, G. F., Schweitzer, P. Kappa opioid receptor activation decreases inhibitory transmission and antagonizes alcohol effects in rat central amygdala Neuropharmacology 2014 77:294-302 DOI:10.1016/j.neuropharm.2013.10.005 PMID:24157490 PMCID:PMC3873141
- Koob, G. F., Buck, C. L., Cohen, A., Edwards, S., Park, P. E., Schlosburg, J. E., Schmeichel, B., Vendruscolo, L. F., Wade, C. L., Whitfield, T. W., George, O. Addiction as a stress surfeit disorder Neuropharmacology 2014 76:370-382 DOI:10.1016/j.neuropharm2013.05.024 PMID:23747571 PMCID:PMC3830720
- Kallupi, M., Vendruscolo, L. F., Carmichael, C. Y., George, O., Koob, G. F., Gilpin, N. W. Neuropeptide Y Y2R blockade in the central amygdala reduces anxiety-like behavior but not alcohol drinking in alcohol-dependent rats Addiction Biology 2014 19:755-757 DOI:10.1111/adb.12059 PMID:23639035 PMCID:PMC3872251
- Wise, R. A., Koob, G. F. The development and maintenance of drug addiction Neuropsychopharmacology 2014 39:254-262 DOI:10.1038/npp.2013.261 PMID:24121188 PMCID:PMC3870778
- Schlosburg, J. E., Whitfield, T. W., Park, P. E., Crawford, E. F., George, O., Vendruscolo, L. F., Koob, G. F. Long-term antagonism of κ opioid receptors prevents escalation of and increased motivation for heroin intake Journal of Neuroscience 2013 33:19384-19392 DOI:10.1523/jneurosci.1979-13.2013 PMID:24305833 PMCID:PMC3850049
- Zorrilla, E. P., Koob, G. F. Amygdalostriatal projections in the neurocircuitry for motivation: a neuroanatomical thread through the career of Ann Kelley Neuroscience and Biobehavioral Reviews 2013 37:1932-1945 DOI:10.1016/j.neubiorev.2012.11.019 PMID:23220696 PMCID:PMC3838492
- Apkarian, A. V., Neugebauer, V., Koob, G., Edwards, S., Levine, J. D., Ferrari, L., Egli, M., Regunathan, S. Neural mechanisms of pain and alcohol dependence Pharmacology, Biochemistry and Behavior 2013 112:34-41 DOI:10.1016/j.pbb.2013.09.008 PMID:24095683 PMCID:PMC4887744
- Cai, X., Whitfield, T., Moreno, A. Y., Grant, Y., Hixon, M. S., Koob, G. F., Janda, K. D. Probing the effects of hapten stability on cocaine vaccine immunogenicity Molecular Pharmaceutics 2013 10:4176-4184 DOI:10.1021/mp400214w PMID:23927436 PMCID:PMC3946501
- Maoz, A., Hicks, M. J., Vallabhjosula, S., Synan, M., Kothari, P. J., Dyke, J. P., Ballon, D. J., Kaminsky, S. M., De, B. P., Rosenberg, J. B., Martinez, D., Koob, G. F., et al. Adenovirus capsid-based anti-cocaine vaccine prevents cocaine from binding to the nonhuman primate CNS dopamine transporter Neuropsychopharmacology 2013 38:2170-2178 DOI:10.1038/npp.2013.114 PMID:23660705 PMCID:PMC3773666
- Kallupi, M., Wee, S., Edwards, S., Whitfield, T. W., Oleata, C. S., Luu, G., Schmeichel, B. E., Koob, G. F., Roberto, M. Kappa opioid receptor-mediated dysregulation of gamma-aminobutyric acidergic transmission in the central amygdala in cocaine addiction Biological Psychiatry 2013 74:520-528 DOI:10.1016/j.biopsych.2013.04.028 PMID:23751206 PMCID:PMC3773286
- Park, P. E., Vendruscolo, L. F., Schlosburg, J. E., Edwards, S., Schulteis, G., Koob, G. F. Corticotropin-releasing factor (CRF) and alpha 2 adrenergic receptors mediate heroin withdrawal-potentiated startle in rats International Journal of Neuropsychopharmacology 2013 16:1867-1875 DOI:10.1017/s1461145713000308 PMID:23590881 PMCID:PMC3880138
- Edwards, S., Koob, G. F. Escalation of drug self-administration as a hallmark of persistent addiction liability Behavioural Pharmacology 2013 24:356-362 DOI:10.1097/FBP.0b013e3283644d15 PMID:23839030 PMCID:PMC3866817
- Zorrilla, E. P., Roberts, A. J., Rivier, J. E., Koob, G. F. Anxiolytic-Like Effects of Antisauvagine-30 in Mice Are Not Mediated by CRF2 Receptors PLoS One 2013 8:e63942 DOI:10.1371/journal.pone.0063942 PMID:24015170 PMCID:PMC3756045
- Koob, G. F. Negative reinforcement in drug addiction: the darkness within Current Opinion in Neurobiology 2013 23:559-563 DOI:10.1016/j.conb.2013.03.011 PMID:23628232
- Edwards, S., Baynes, B. B., Carmichael, C. Y., Zamora-Martinez, E. R., Barrus, M., Koob, G. F., Gilpin, N. W. Traumatic stress reactivity promotes excessive alcohol drinking and alters the balance of prefrontal cortex-amygdala activity Translational Psychiatry 2013 3:e296 DOI:10.1038/tp.2013.70 PMID:23982628 PMCID:PMC3756295
- Chen, J. H., Repunte-Canonigo, V., Kawamura, T., Lefebvre, C., Shin, W., Howell, L. L., Hemby, S. E., Harvey, B. K., Califano, A., Morales, M., Koob, G. F., Sanna, P. P. Hypothalamic proteoglycan syndecan-3 is a novel cocaine addiction resilience factor Nature Communications 2013 4:1955 DOI:10.1038/ncomms2955 PMID:23736082 PMCID:PMC3709481
- Schlosburg, J. E., Vendruscolo, L. F., Bremer, P. T., Lockner, J. W., Wade, C. L., Nunes, A. A., Stowe, G. N., Edwards, S., Janda, K. D., Koob, G. F. Dynamic vaccine blocks relapse to compulsive intake of heroin Proceedings of the National Academy of Sciences of the United States of America 2013 110:9036-9041 DOI:10.1073/pnas.1219159110 PMID:23650354 PMCID:PMC3670323
- Cai, X., Whitfield, T., Hixon, M. S., Grant, Y., Koob, G. F., Janda, K. D. Probing active cocaine vaccination performance through catalytic and noncatalytic hapten design Journal of Medicinal Chemistry 2013 56:3701-3709 DOI:10.1021/jm400228w PMID:23627877 PMCID:PMC3691275
- Barbier, E., Vendruscolo, L. F., Schlosburg, J. E., Edwards, S., Juergens, N., Park, P. E., Misra, K. K., Cheng, K. J., Rice, K. C., Schank, J., Schulteis, G., Koob, G. F., et al. The NK1 receptor antagonist l822429 reduces heroin reinforcement Neuropsychopharmacology 2013 38:976-984 DOI:10.1038/npp.2012.261 PMID:23303056 PMCID:PMC3629386
- Herman, M. A., Kallupi, M., Luu, G., Oleata, C. S., Heilig, M., Koob, G. F., Ciccocioppo, R., Roberto, M. Enhanced gabaergic transmission in the central nucleus of the amygdala of genetically selected marchigian sardinian rats: Alcohol and crf effects Neuropharmacology 2013 67:337-348 DOI:10.1016/j.neuropharm.2012.11.026 PMID:23220399 PMCID:PMC3562384
- George, O., Koob, G. F. Control of craving by the prefrontal cortex Proceedings of the National Academy of Sciences of the United States of America 2013 110:4165-4166 DOI:10.1073/pnas.1301245110 PMID:23483010 PMCID:PMC3600441
- Robison, A. J., Vialou, V., Mazei-Robison, M., Feng, J., Kourrich, S., Collins, M., Wee, S., Koob, G., Turecki, G., Neve, R., Thomas, M., Nestler, E. J. Behavioral and structural responses to chronic cocaine require a feedforward loop involving delta fosb and calcium/calmodulin-dependent protein kinase ii in the nucleus accumbens shell Journal of Neuroscience 2013 33:4295-4307 DOI:10.1523/jneurosci.5192-12.2013 PMID:23467346 PMCID:PMC3658178
- Jang, C. G., Whitfield, T., Schulteis, G., Koob, G. F., Wee, S. A dysphoric-like state during early withdrawal from extended access to methamphetamine self-administration in rats Psychopharmacology 2013 225:753-763 DOI:10.1007/s00213-012-2864-0 PMID:23007601 PMCID:PMC3547144
- Koob, G. F. Addiction is a reward deficit and stress surfeit disorder Frontiers in Psychiatry 2013 4:72 DOI:10.3389/fpsyt.2013.00072 PMID:23914176 PMCID:PMC3730086
- Kreifeldt, M., Le, D., Treistman, S. N., Koob, G. F., Contet, C. BK channel beta1 and beta4 auxiliary subunits exert opposite influences on escalated ethanol drinking in dependent mice Frontiers in Integrative Neuroscience 2013 7:105 DOI:10.3389/fnint.2013.00105 PMID:24416005 PMCID:PMC3874544
- De, B. P., Pagovich, O. E., Hicks, M. J., Rosenberg, J. B., Moreno, A. Y., Janda, K. D., Koob, G. F., Worgall, S., Kaminsky, S. M., Sondhi, D., Crystal, R. G. Disrupted adenovirus-based vaccines against small addictive molecules circumvent anti-adenovirus immunity Human Gene Therapy 2013 24:58-66 DOI:10.1089/hum.2012.163 PMID:23140508 PMCID:PMC3555097
- Koob, G. F. Theoretical frameworks and mechanistic aspects of alcohol addiction: Alcohol addiction as a reward deficit disorder Current Topics in Behavioral Neurosciences 2013 13:3-30 DOI:10.1007/7854_2011_129 PMID:21744309 PMCID:PMC3448980
- Lenoir, M., Guillem, K., Koob, G. F., Ahmed, S. H. Drug specificity in extended access cocaine and heroin self-administration Addiction Biology 2012 17:964-976 DOI:10.1111/j.1369-1600.2011.00385.x PMID:21995515
- George, O., Sanders, C., Freiling, J., Grigoryan, E., Vu, S., Allen, C. D., Crawford, E., Mandyam, C. D., Koob, G. F. Recruitment of medial prefrontal cortex neurons during alcohol withdrawal predicts cognitive impairment and excessive alcohol drinking Proceedings of the National Academy of Sciences of the United States of America 2012 109:18156-18161 DOI:10.1073/pnas.1116523109 PMID:23071333 PMCID:PMC3497825
- Moreno, A. Y., Azar, M. R., Koob, G. F., Janda, K. D. Probing the protective effects of a conformationally constrained nicotine vaccine Vaccine 2012 30:6665-6670 DOI:10.1016/j.vaccine.2012.08.064 PMID:22963803
- Goeders, N. E., Cohen, A., Fox, B. S., Azar, M. R., George, O., Koob, G. F. Effects of the combination of metyrapone and oxazepam on intravenous nicotine self-administration in rats Psychopharmacology 2012 223:17-25 DOI:10.1007/s00213-012-2682-4 PMID:22418732 PMCID:PMC3464482
- Tobey, K. M., Walentiny, D. M., Wiley, J. L., Carroll, F. I., Damaj, M. I., Azar, M. R., Koob, G. F., George, O., Harris, L. S., Vann, R. E. Effects of the specific alpha 4 beta 2 nachr antagonist, 2-fluoro-3-(4-nitrophenyl) deschloroepibatidine, on nicotine reward-related behaviors in rats and mice Psychopharmacology 2012 223:159-168 DOI:10.1007/s00213-012-2703-3 PMID:22526534 PMCID:PMC3464481
- Wee, S., Vendruscolo, L. F., Misra, K. K., Schlosburg, J. E., Koob, G. F. A combination of buprenorphine and naltrexone blocks compulsive cocaine intake in rodents without producing dependence Science Translational Medicine 2012 4:146ra110 DOI:10.1126/scitranslmed.3003948 PMID:22875830 PMCID:PMC3448552
- Cohen, A., Koob, G. F., George, O. Robust escalation of nicotine intake with extended access to nicotine self-administration and intermittent periods of abstinence Neuropsychopharmacology 2012 37:2153-2160 DOI:10.1038/npp.2012.67 PMID:22549121 PMCID:PMC3398720
- Higley, A. E., Koob, G. F., Mason, B. J. Treatment of alcohol dependence with drug antagonists of the stress response Alcohol Research: Current Reviews 2012 34:516-521 PMID:23584117 PMCID:PMC3860394
- Vendruscolo, L. F., Barbier, E., Schlosburg, J. E., Misra, K. K., Whitfield, T. W., Logrip, M. L., Rivier, C., Repunte-Canonigo, V., Zorrilla, E. P., Sanna, P. P., Heilig, M., Koob, G. F. Corticosteroid-dependent plasticity mediates compulsive alcohol drinking in rats Journal of Neuroscience 2012 32:7563-7571 DOI:10.1523/jneurosci.0069-12.2012 PMID:22649234 PMCID:PMC3375621
- Rosenberg, J. B., Hicks, M. J., De, B. P., Pagovich, O., Frenk, E., Janda, K. D., Wee, S., Koob, G. F., Hackett, N. R., Kaminsky, S. M., Worgall, S., Tignor, N., et al. AAVrh.10-mediated expression of an anti-cocaine antibody mediates persistent passive immunization that suppresses cocaine-induced behavior Human Gene Therapy 2012 23:451-459 DOI:10.1089/hum.2011.178 PMID:22486244 PMCID:PMC3360503
- George, O., Le Moal, M., Koob, G. F. Allostasis and addiction: role of the dopamine and corticotropin-releasing factor systems Physiology and Behavior 2012 106:58-64 DOI:10.1016/j.physbeh.2011.11.004 PMID:22108506 PMCID:PMC3288230
- Recinto, P., Samant, A. R. H., Chavez, G., Kim, A., Yuan, C. J., Soleiman, M., Grant, Y., Edwards, S., Wee, S., Koob, G. F., George, O., Mandyam, C. D. Levels of neural progenitors in the hippocampus predict memory impairment and relapse to drug seeking as a function of excessive methamphetamine self-administration Neuropsychopharmacology 2012 37:1275-1287 DOI:10.1038/npp.2011.315 PMID:22205547 PMCID:PMC3306889
- Wee, S., Hicks, M. J., De, B. P., Rosenberg, J. B., Moreno, A. Y., Kaminsky, S. M., Janda, K. D., Crystal, R. G., Koob, G. F. Novel cocaine vaccine linked to a disrupted adenovirus gene transfer vector blocks cocaine psychostimulant and reinforcing effects Neuropsychopharmacology 2012 37:1083-1091 DOI:10.1038/npp.2011.200 PMID:21918504 PMCID:PMC3306868
- Mandyam, C. D., Koob, G. F. The addicted brain craves new neurons: Putative role for adult-born progenitors in promoting recovery Trends in Neurosciences 2012 35:250-260 DOI:10.1016/j.tins.2011.12.005 PMID:22265158 PMCID:PMC3321119
- Zorrilla, E. P., Wee, S., Zhao, Y., Specio, S., Boutrel, B., Koob, G. F., Weiss, F. Extended access cocaine self-administration differentially activates dorsal raphe and amygdala corticotropin-releasing factor systems in rats Addiction Biology 2012 17:300-308 DOI:10.1111/j.1369-1600.2011.00329.x PMID:21762287 PMCID:PMC3304464
- Edwards, S., Vendruscolo, L. F., Schlosburg, J. E., Misra, K. K., Wee, S., Park, P. E., Schulteis, G., Koob, G. F. Development of mechanical hypersensitivity in rats during heroin and ethanol dependence: Alleviation by crf1 receptor antagonism Neuropharmacology 2012 62:1142-1151 DOI:10.1016/j.neuropharm.2011.11.006 PMID:22119954 PMCID:PMC3262951
- Logrip, M. L., Zorrilla, E. P., Koob, G. F. Stress modulation of drug self-administration: Implications for addiction comorbidity with post-traumatic stress disorder Neuropharmacology 2012 62:552-564 DOI:10.1016/j.neuropharm.2011.07.007 PMID:21782834 PMCID:PMC3206986
- Edwards, S., Guerrero, M., Ghoneim, O. M., Roberts, E., Koob, G. F. Evidence that vasopressin V(1b) receptors mediate the transition to excessive drinking in ethanol-dependent rats Addiction Biology 2012 17:76-85 DOI:10.1111/j.1369-1600.2010.00291.x PMID:21309953 PMCID:PMC3178679
- Edwards, S., Koob, G. F. Experimental psychiatric illness and drug abuse models: from human to animal, an overview Methods in Molecular Biology 2012 829:31-48 DOI:10.1007/978-1-61779-458-2_2 PMID:22231805 PMCID:PMC3285446
- Blednov, Y. A., Ponomarev, I., Geil, C., Bergeson, S., Koob, G. F., Harris, R. A. Neuroimmune regulation of alcohol consumption: Behavioral validation of genes obtained from genomic studies Addiction Biology 2012 17:108-120 DOI:10.1111/j.1369-1600.2010.00284.x PMID:21309947 PMCID:PMC3117922
- Koob, G., Hicks, M. J., Wee, S., Rosenberg, J. B., De, B. P., Kaminksy, S. M., Moreno, A., Janda, K. D., Crystal, R. G. Anti-cocaine vaccine based on coupling a cocaine analog to a disrupted adenovirus CNS and Neurological Disorders-Drug Targets 2011 10:899-904 PMID:22229312 PMCID:PMC3369545
- Stowe, G. N., Schlosburg, J. E., Vendruscolo, L. F., Edwards, S., Misra, K. K., Schulteis, G., Zakhari, J. S., Koob, G. F., Janda, K. D. Developing a vaccine against multiple psychoactive targets: a case study of heroin CNS & Neurological Disorders-Drug Targets 2011 10:865-875 PMID:22229311 PMCID:PMC3327724
- Fekete, E. M., Zhao, Y., Szucs, A., Sabino, V., Cottone, P., Rivier, J., Vale, W. W., Koob, G. F., Zorrilla, E. P. Systemic urocortin 2, but not urocortin 1 or stressin1-a, suppresses feeding via crf2 receptors without malaise and stress British Journal of Pharmacology 2011 164:1959-1975 DOI:10.1111/j.1476-5381.2011.01512.x PMID:21627635 PMCID:PMC3246660
- Contet, C., Gardon, O., Filliol, D., Becker, J. A. J., Koob, G. F., Kieffer, B. L. Identification of genes regulated in the mouse extended amygdala by excessive ethanol drinking associated with dependence Addiction Biology 2011 16:615-619 DOI:10.1111/j.1369-1600.2010.00304.x PMID:21392173 PMCID:PMC3139763
- Mihindou, C., Vouillac, C., Koob, G. F., Ahmed, S. H. Preclinical validation of a novel cocaine exposure therapy for relapse prevention Biological Psychiatry 2011 70:593-598 DOI:10.1016/j.biopsych.2011.03.036 PMID:21571256 PMCID:PMC3157564
- Stowe, G. N., Vendruscolo, L. F., Edwards, S., Schlosburg, J. E., Misra, K. K., Schulteis, G., Mayorov, A. V., Zakhari, J. S., Koob, G. F., Janda, K. D. A vaccine strategy that induces protective immunity against heroin Journal of Medicinal Chemistry 2011 54:5195-5204 DOI:10.1021/jm200461m PMID:21692508 PMCID:PMC3142939
- Parylak, S. L., Koob, G. F., Zorrilla, E. P. The dark side of food addiction Physiology & Behavior 2011 104:149-156 DOI:10.1016/j.physbeh.2011.04.063 PMID:21557958 PMCID:PMC3304465
- Vendruscolo, L. F., Schlosburg, J. E., Misra, K. K., Chen, S. A., Greenwell, T. N., Koob, G. F. Escalation patterns of varying periods of heroin access Pharmacology, Biochemistry and Behavior 2011 98:570-574 DOI:10.1016/j.pbb.2011.03.004 PMID:21406200 PMCID:PMC3081940
- Allen, C. D., Lee, S., Koob, G. F., Rivier, C. Immediate and prolonged effects of alcohol exposure on the activity of the hypothalamic-pituitary-adrenal axis in adult and adolescent rats Brain Behavior and Immunity 2011 25:S50-S60 DOI:10.1016/j.bbi.2011.01.016 PMID:21300146 PMCID:PMC3098294
- Gilpin, N. W., Misra, K., Herman, M. A., Cruz, M. T., Koob, G. F., Roberto, M. Neuropeptide y opposes alcohol effects on gamma-aminobutyric acid release in amygdala and blocks the transition to alcohol dependence Biological Psychiatry 2011 69:1091-1099 DOI:10.1016/j.biopsych.2011.02.004 PMID:21459365 PMCID:PMC3090491
- Sabino, V., Cottone, P., Blasio, A., Iyer, M. R., Steardo, L., Rice, K. C., Conti, B., Koob, G. F., Zorrilla, E. P. Activation of σ-receptors induces binge-like drinking in Sardinian alcohol-preferring rats Neuropsychopharmacology 2011 36:1207-1218 DOI:10.1038/npp.2011.5 PMID:21346735 PMCID:PMC3079320
- George, O., Koob, G. F. Craving, context and the cortex Nature Neuroscience 2011 14:409-410 DOI:10.1038/nn.2787 PMID:21445066 PMCID:PMC3829767
- Hicks, M. J., De, B. P., Rosenberg, J. B., Davidson, J. T., Moreno, A. Y., Janda, K. D., Wee, S., Koob, G. F., Hackett, N. R., Kaminsky, S. M., Worgall, S., Toth, M., et al. Cocaine analog coupled to disrupted adenovirus: A vaccine strategy to evoke high-titer immunity against addictive drugs Molecular Therapy 2011 19:612-619 DOI:10.1038/mt.2010.280 PMID:21206484 PMCID:PMC3048190
- Ali, S. F., Onaivi, E. S., Dodd, P. R., Cadet, J. L., Schenk, S., Kuhar, M. J., Koob, G. F. Understanding the global problem of drug addiction is a challenge for IDARS scientists Current Neuropharmacology 2011 9:2-7 DOI:10.2174/157015911795017245 PMID:21886551 PMCID:PMC3137181
- George, O., Lloyd, A., Carroll, F. I., Damaj, M. I., Koob, G. F. Varenicline blocks nicotine intake in rats with extended access to nicotine self-administration Psychopharmacology 2011 213:715-722 DOI:10.1007/s00213-010-2024-3 PMID:20924754 PMCID:PMC3033995
- Logrip, M. L., Koob, G. F., Zorrilla, E. P. Role of corticotropin-releasing factor in drug addiction potential for pharmacological intervention CNS Drugs 2011 25:271-287 DOI:10.2165/11587790-000000000-00000 PMID:21425881 PMCID:PMC3273042
- Walker, B. M., Zorrilla, E. P., Koob, G. F. Systemic kappa-opioid receptor antagonism by nor-binaltorphimine reduces dependence-induced excessive alcohol self-administration in rats Addiction Biology 2011 16:116-119 DOI:10.1111/j.1369-1600.2010.00226.x PMID:20579007 PMCID:PMC2988980
- George, O., Koob, G. F. Individual differences in prefrontal cortex function and the transition from drug use to drug dependence Neuroscience and Biobehavioral Reviews 2010 35:232-247 DOI:10.1016/j.neubiorev.2010.05.002 PMID:20493211 PMCID:PMC2955797
- Gilpin, N. W., Koob, G. F. Effects of beta-adrenoceptor antagonists on alcohol drinking by alcohol-dependent rats Psychopharmacology 2010 212:431-439 DOI:10.1007/s00213-010-1967-8 PMID:20676608 PMCID:PMC2966867
- George, O., Grieder, T. E., Cole, M., Koob, G. F. Exposure to chronic intermittent nicotine vapor induces nicotine dependence Pharmacology, Biochemistry and Behavior 2010 96:104-107 DOI:10.1016/j.pbb.2010.04.013 PMID:20420848 PMCID:PMC2878929
- Orio, L., Wee, S., Newman, A. H., Pulvirenti, L., Koob, G. F. The dopamine d3 receptor partial agonist cjb090 and antagonist pg01037 decrease progressive ratio responding for methamphetamine in rats with extended-access Addiction Biology 2010 15:312-323 DOI:10.1111/j.1369-1600.2010.00211.x PMID:20456290 PMCID:PMC2903631
- Wee, S., Koob, G. F. The role of the dynorphin-kappa opioid system in the reinforcing effects of drugs of abuse Psychopharmacology 2010 210:121-135 DOI:10.1007/s00213-010-1825-8 PMID:20352414 PMCID:PMC2879894
- Roberto, M., Cruz, M. T., Gilpin, N. W., Sabin, V., Schweitzer, P., Bajo, M., Cottone, P., Madamba, S. G., Stouffer, D. G., Zorrilla, E. P., Koob, G. F., Siggins, G. R., et al. Corticotropin releasing factor-induced amygdala gamma-aminobutyric acid release plays a key role in alcohol dependence Biological Psychiatry 2010 67:831-839 DOI:10.1016/j.biopsych.2009.11.007 PMID:20060104 PMCID:PMC2883449
- Zorrilla, E. P., Koob, G. F. Progress in corticotropin-releasing factor-1 antagonist development Drug Discovery Today 2010 15:371-383 DOI:10.1016/j.drudis.2010.02.011 PMID:20206287 PMCID:PMC2864802
- Moreno, A. Y., Azar, M. R., Warren, N. A., Dickerson, T. J., Koob, G. F., Janda, K. D. A critical evaluation of a nicotine vaccine within a self-administration behavioral model Molecular Pharmaceutics 2010 7:431-441 DOI:10.1021/mp900213u PMID:20104903
- Koob, G. F. The role of crf and crf-related peptides in the dark side of addiction Brain Research 2010 1314:3-14 DOI:10.1016/j.brainres.2009.11.008 PMID:19912996 PMCID:PMC2819562
- Koob, G. F., Zorrilla, E. P. Neurobiological mechanisms of addiction: Focus on corticotropin-releasing factor Current Opinion in Investigational Drugs 2010 11:63-71 PMID:20047160 PMCID:PMC2812895
- Koob, G. F., Volkow, N. D. Neurocircuitry of addiction Neuropsychopharmacology 2010 35:217-238 DOI:10.1038/npp.2009.110 PMID:19710631 PMCID:PMC2805560
- Shurman, J., Koob, G. F., Gutstein, H. B. Opioids, pain, the brain, and hyperkatifeia: a framework for the rational use of opioids for pain Pain Medicine 2010 11:1092-1098 DOI:10.1111/j.1526-4637.2010.00881.x PMID:20545871 PMCID:PMC2907890
- Gilpin, N. W., Smith, A. D., Cole, M., Weiss, F., Koob, G. F., Richardson, H. N. Operant behavior and alcohol levels in blood and brain of alcohol-dependent rats Alcoholism-Clinical and Experimental Research 2009 33:2113-2123 DOI:10.1111/j.1530-0277.2009.01051.x PMID:19740131 PMCID:PMC2789881
- Cottone, P., Sabino, V., Roberto, M., Bajo, M., Pockros, L., Frihauf, J. B., Fekete, E. M., Steardo, L., Rice, K. C., Grigoriadis, D. E., Conti, B., Koob, G. F., et al. CRF system recruitment mediates dark side of compulsive eating Proceedings of the National Academy of Sciences of the United States of America 2009 106:20016-20020 DOI:10.1073/pnas.0908789106 PMID:19901333 PMCID:PMC2785284
- Francesconi, W., Berton, F., Koob, G. F., Sanna, P. P. Intrinsic neuronal plasticity in the juxtacapsular nucleus of the bed nuclei of the stria terminalis (jcBNST) Progress in Neuro-Psychopharmacology & Biological Psychiatry 2009 33:1347-1355 DOI:10.1016/j.pnpbp.2009.08.003 PMID:19683025 PMCID:PMC2935256
- Tabakoff, B., Saba, L., Printz, M., Flodman, P., Hodgkinson, C., Goldman, D., Koob, G., Richardson, H. N., Kechris, K., Bell, R. L., Hubner, N., Heinig, M., et al. Genetical genomic determinants of alcohol consumption in rats and humans BMC Biology 2009 7:70 DOI:10.1186/1741-7007-7-70 PMID:19874574 PMCID:PMC2777866
- Koob, G. F. Brain stress systems in the amygdala and addiction Brain Research 2009 1293:61-75 DOI:10.1016/j.brainres.2009.03.038 PMID:19332030 PMCID:PMC2774745
- Richardson, H. N., Chan, S. H., Crawford, E. F., Lee, Y. K., Funk, C. K., Koob, G. F., Mandyam, C. D. Permanent impairment of birth and survival of cortical and hippocampal proliferating cells following excessive drinking during alcohol dependence Neurobiology of Disease 2009 36:1-10 DOI:10.1016/j.nbd.2009.05.021 PMID:19501165 PMCID:PMC2742572
- Wee, S., Orio, L., Ghirmai, S., Cashman, J. R., Koob, G. F. Inhibition of kappa opioid receptors attenuated increased cocaine intake in rats with extended access to cocaine Psychopharmacology 2009 205:565-575 DOI:10.1007/s00213-009-1563-y PMID:19484223 PMCID:PMC2739447
- Sabino, V., Cottone, P., Zhao, Y., Steardo, L., Koob, G. F., Zorrilla, E. P. Selective reduction of alcohol drinking in sardinian alcohol-preferring rats by a sigma-1 receptor antagonist Psychopharmacology 2009 205:327-335 DOI:10.1007/s00213-009-1548-x PMID:19440699 PMCID:PMC2748837
- Koob, G. F., Lloyd, G. K., Mason, B. J. Development of pharmacotherapies for drug addiction: a Rosetta stone approach Nature Reviews Drug Discovery 2009 8:500-515 DOI:10.1038/nrd2828 PMID:19483710 PMCID:PMC2760328
- Sabino, V., Cottone, P., Zhao, Y., Iyer, M. R., Steardo, L., Rice, K. C., Conti, B., Rice, K. C., Koob, G. F., Zorrilla, E. P. The sigma-receptor antagonist BD-1063 decreases ethanol intake and reinforcement in animal models of excessive drinking Neuropsychopharmacology 2009 34:1482-1493 DOI:10.1038/npp.2008.192 PMID:18946467 PMCID:PMC2669694
- Francesconi, W., Berton, F., Repunte-Canonigo, V., Hagihara, K., Thurbon, D., Lekic, D., Specio, S. E., Greenwell, T. N., Chen, S. A., Rice, K. C., Richardson, H. N., O'Dell, L. E., et al. Protracted withdrawal from alcohol and drugs of abuse impairs long-term potentiation of intrinsic excitability in the juxtacapsular bed nucleus of the stria terminalis Journal of Neuroscience 2009 29:5389-5401 DOI:10.1523/jneurosci.5129-08.2009 PMID:19403807 PMCID:PMC2938175
- Orio, L., Edwards, S., George, O., Parsons, L. H., Koob, G. F. A role for the endocannabinoid system in the increased motivation for cocaine in extended-access conditions Journal of Neuroscience 2009 29:4846-4857 DOI:10.1523/jneurosci.0563-09.2009 PMID:19369553 PMCID:PMC2688678
- Greenwell, T. N., Funk, C. K., Cottone, P., Richardson, H. N., Chen, S. A., Rice, K. C., Zorrilla, E. P., Koob, G. F. Corticotropin-releasing factor-1 receptor antagonists decrease heroin self-administration in long- but not short-access rats Addiction Biology 2009 14:130-143 DOI:10.1111/j.1369-1600.2008.00142.x PMID:19291009 PMCID:PMC2748834
- Koob, G. F. Dynamics of neuronal circuits in addiction: Reward, antireward, and emotional memory Pharmacopsychiatry 2009 42:S32-S41 DOI:10.1055/s-0029-1216356 PMID:19434554 PMCID:PMC2739305
- Koob, G. F. Neurobiological substrates for the dark side of compulsivity in addiction Neuropharmacology 2009 56:18-31 DOI:10.1016/j.neuropharm.2008.07.043 PMID:18725236 PMCID:PMC2637927
- Koob, G. F. New dimensions in human laboratory models of addiction Addiction Biology 2009 14:1-8 DOI:10.1111/j.1369-1600.2008.00127.x PMID:19133879
- Greenwell, T. N., Walker, B. M., Cottone, P., Zorrilla, E. P., Koob, G. F. The alpha(1) adrenergic receptor antagonist prazosin reduces heroin self-administration in rats with extended access to heroin administration Pharmacology, Biochemistry and Behavior 2009 91:295-302 DOI:10.1016/j.pbb.2008.07.012 PMID:18703080 PMCID:PMC2637926
- Mandyam, C. D., Wee, S., Crawford, E. F., Eisch, A. J., Richardson, H. N., Koob, G. F. Varied access to intravenous methamphetamine self-administration differentially alters adult hippocampal neurogenesis Biological Psychiatry 2008 64:958-965 DOI:10.1016/j.biopsych.2008.04.010 PMID:18490002 PMCID:PMC2587157
- Papaleo, F., Ghozland, S., Ingallinesi, M., Roberts, A. J., Koob, G. F., Contarino, A. Disruption of the CRF(2) receptor pathway decreases the somatic expression of opiate withdrawal Neuropsychopharmacology 2008 33:2878-2887 DOI:10.1038/npp.2008.8 PMID:18288089 PMCID:PMC2760329
- Koob, G. F., Le Moal, M. Neurobiological mechanisms for opponent motivational processes in addiction Philosophical Transactions of the Royal Society B-Biological Sciences 2008 363:3113-3123 DOI:10.1098/rstb.2008.0094 PMID:18653439 PMCID:PMC2607326
- Richardson, H. N., Lee, S. Y., O'Dell, L. E., Koob, G. F., Rivier, C. L. Alcohol self-administration acutely stimulates the hypothalamic-pituitary-adrenal axis, but alcohol dependence leads to a dampened neuroendocrine state European Journal of Neuroscience 2008 28:1641-1653 DOI:10.1111/j.1460-9568.2008.06455.x PMID:18979677 PMCID:PMC2748838
- Du, X., Schwander, M., Moresco, E. M. Y., Viviani, P., Haller, C., Hildebrand, M. S., Pak, K., Tarantino, L., Roberts, A., Richardson, H., Koob, G., Najmabadi, H., et al. A catechol-O-methyltransferase that is essential for auditory function in mice and humans Proceedings of the National Academy of Sciences of the United States of America 2008 105:14609-14614 DOI:10.1073/pnas.0807219105 PMID:18794526 PMCID:PMC2567147
- Gilpin, N. W., Richardson, H. N., Lumeng, L., Koob, G. F. Dependence-induced alcohol drinking by alcohol-preferring (p) rats and outbred wistar rats Alcoholism-Clinical and Experimental Research 2008 32:1688-1696 DOI:10.1111/j.1530-0277.2008.00678.x PMID:18482158 PMCID:PMC2583092
- Gilpin, N. W., Richardson, H. N., Koob, G. F. Effects of crf(1)-receptor and opioid-receptor antagonists on dependence-induced increases in alcohol drinking by alcohol-preferring (p) rats Alcoholism-Clinical and Experimental Research 2008 32:1535-1542 DOI:10.1111/j.1530-0277.2008.00745.x PMID:18631323 PMCID:PMC2583093
- George, O., Mandyam, C. D., Wee, S., Koob, G. F. Extended access to cocaine self-administration produces long-lasting prefrontal cortex-dependent working memory impairments Neuropsychopharmacology 2008 33:2474-2482 DOI:10.1038/sj.npp.1301626 PMID:18033234 PMCID:PMC2760333
- Gilpin, N. W., Misra, K., Koob, G. F. Neuropeptide y in the central nucleus of the amygdala suppresses dependence-induced increases in alcohol drinking Pharmacology, Biochemistry and Behavior 2008 90:475-480 DOI:10.1016/j.pbb.2008.04.006 PMID:18501411 PMCID:PMC2480495
- Koob, G. F. A role for brain stress systems in addiction Neuron 2008 59:11-34 DOI:10.1016/j.neuron.2008.06.012 PMID:18614026 PMCID:PMC2748830
- Roberto, M., Gilpin, N. W., O'Dell, L. E., Cruz, M. T., Morse, A. C., Siggins, G. R., Koob, G. F. Cellular and behavioral interactions of gabapentin with alcohol dependence Journal of Neuroscience 2008 28:5762-5771 DOI:10.1523/jneurosci.0575-08.2008 PMID:18509038 PMCID:PMC2493536
- Wee, S., Mandyam, C. D., Lekic, D. M., Koob, G. F. Alpha(1)-noradrenergic system role in increased motivation for cocaine intake in rats with prolonged access European Neuropsychopharmacology 2008 18:303-311 DOI:10.1016/j.euroneuro.2007.08.003 PMID:17920248 PMCID:PMC2376122
- Walker, B. M., Rasmussen, D. D., Raskind, M. A., Koob, G. F. Alpha(1)-noradrenergic receptor antagonism blocks dependence-induced increases in responding for ethanol Alcohol 2008 42:91-97 DOI:10.1016/j.alcohol.2007.12.002 PMID:18358987 PMCID:PMC2587143
- Specio, S. E., Wee, S., O'Dell, L. E., Boutrel, B., Zorrilla, E. P., Koob, G. F. Crf1 receptor antagonists attenuate escalated cocaine self-administration in rats Psychopharmacology 2008 196:473-482 DOI:10.1007/s00213-007-0983-9 PMID:17965976 PMCID:PMC2769571
- Ji, D., Gilpin, N. W., Richardson, H. N., Rivier, C. L., Koob, G. F. Effects of naltrexone, duloxetine, and a corticotropin-releasing factor type 1 receptor antagonist on binge-like alcohol drinking in rats Behavioural Pharmacology 2008 19:1-12 DOI:10.1097/FBP.0b013e3282f3cf70 PMID:18195589 PMCID:PMC2586833
- Richardson, H. N., Zhao, Y., Fekete, E. M., Funk, C. K., Wirsching, P., Janda, K. D., Zorrilla, E. P., Koob, G. F. MPZP: A novel small molecule corticotropin-releasing factor type 1 receptor (CRF1) antagonist Pharmacology, Biochemistry and Behavior 2008 88:497-510 DOI:10.1016/j.pbb.2007.10.008 PMID:18031798 PMCID:PMC3319109
- Walker, B. M., Koob, G. F. Pharmacological evidence for a motivational role of kappa-opioid systems in ethanol dependence Neuropsychopharmacology 2008 33:643-652 DOI:10.1038/sj.npp.1301438 PMID:17473837 PMCID:PMC2739278
- Guillem, K., Vouillac, C., Koob, G. F., Cador, M., Stinus, L. Monoamine oxidase inhibition dramatically prolongs the duration of nicotine withdrawal-induced place aversion Biological Psychiatry 2008 63:158-163 DOI:10.1016/j.biopsych.2007.04-029 PMID:17643399
- Caine, S. B., Thomsen, M., Gabriel, K. I., Berkowitz, J. S., Gold, L. H., Koob, G. F., Tonegawa, S., Zhang, J. H., Xu, M. Lack of self-administration of cocaine in dopamine d-1 receptor knock-out mice Journal of Neuroscience 2007 27:13140-13150 DOI:10.1523/jneurosci.2284-07.2007 PMID:18045908
- Zhang, Z., Morse, A. C., Koob, G. F., Schulteis, G. Dose- and time-dependent expression of anxiety-like behavior in the elevated plus-maze during withdrawal from acute and repeated intermittent ethanol intoxication in rats Alcoholism-Clinical and Experimental Research 2007 31:1811-1819 DOI:10.1111/j.1530-0277.2007.00483.x PMID:17877783 PMCID:PMC2367334
- George, O., Ghozland, S., Azar, M. R., Cottone, P., Zorrilla, E. P., Parsons, L. H., O'Dell, L. E., Richardson, H. N., Koob, G. F. CRF-CRF1 system activation mediates withdrawal-induced increases in nicotine self-administration in nicotine-dependent rats Proceedings of the National Academy of Sciences of the United States of America 2007 104:17198-17203 DOI:10.1073/pnas.0707585104 PMID:17921249 PMCID:PMC2040467
- Mandyam, C. D., Wee, S., Eisch, A. J., Richardson, H. N., Koob, G. F. Methamphetamine self-administration and voluntary exercise have opposing effects on medial prefrontal cortex gliogenesis Journal of Neuroscience 2007 27:11442-11450 DOI:10.1523/jneurosci.2505-07.2007 PMID:17942739
- Wee, S., Wang, Z., Woolverton, W. L., Pulvirenti, L., Koob, G. F. Effect of aripiprazole, a partial dopamine d-2 receptor agonist, on increased rate of methamphetamine self-administration in rats with prolonged session duration Neuropsychopharmacology 2007 32:2238-2247 DOI:10.1038/sj.npp.1301353 PMID:17327886 PMCID:PMC2747088
- Tabarin, A., Diz-Chaves, Y., Consoli, D., Monsaingeon, M., Bale, T. L., Culler, M. D., Datta, R., Drago, F., Vale, W. W., Koob, G. F., Zorrilla, E. P., Contarino, A. Role of the corticotropin-releasing factor receptor type 2 in the control of food intake in mice: A meal pattern analysis European Journal of Neuroscience 2007 26:2303-2314 DOI:10.1111/j.1460-9568.2007.05856.x PMID:17953621 PMCID:PMC2741498
- Heilig, M., Koob, G. F. A key role for corticotropin-releasing factor in alcohol dependence Trends in Neurosciences 2007 30:399-406 DOI:10.1016/j.tins.2007.06.006 PMID:17629579 PMCID:PMC2747092
- Koob, G., Kreek, M. J. Stress, dysregulation of drug reward pathways, and the transition to drug dependence American Journal of Psychiatry 2007 164:1149-1159 DOI:10.1176/appi.ajp.2007.05030503 PMID:17671276 PMCID:PMC2837343
- Treweek, J., Wee, S., Koob, G. F., Dickerson, T. J., Janda, K. D. Self-vaccination by methamphetamine glycation products chemically links chronic drug abuse and cardiovascular disease Proceedings of the National Academy of Sciences of the United States of America 2007 104:11580-11584 DOI:10.1073/pnas.0701328104 PMID:17592122 PMCID:PMC1913859
- Funk, C. K., Koob, G. F. A crf2 agonist administered into the central nucleus of the amygdala decreases ethanol self-administration in ethanol-dependent rats Brain Research 2007 1155:172-178 DOI:10.1016/j.brainres.2007.04.009 PMID:17512918 PMCID:PMC2741495
- Fekete, E. M., Inoue, K., Zhao, Y., Rivier, J. E., Vale, W. W., Szucs, A., Koob, G. F., Zorrilla, E. P. Delayed satiety-like actions and altered feeding microstructure by a selective type 2 corticotropin-releasing factor agonist in rats: Intra-hypothalamic urocortin 3 administration reduces food intake by prolonging the post-meal interval Neuropsychopharmacology 2007 32:1052-1068 DOI:10.1038/sj.npp.1301214 PMID:17019404 PMCID:PMC2748839
- Le Moal, M., Koob, G. F. Drug addiction: Pathways to the disease and pathophysiological perspectives European Neuropsychopharmacology 2007 17:377-393 DOI:10.1016/j.euroneuro.2006.10.006 PMID:171695
- Thorsell, A., Repunte-Canonigo, V., O'Dell, L. E., Chen, S. A., King, A. R., Lekic, D., Koob, G. F., Sanna, P. P. Viral vector-induced amygdala NPY overexpression reverses increased alcohol intake caused by repeated deprivations in Wistar rats Brain 2007 130:1330-1337 DOI:10.1093/brain/awm033 PMID:17405766 PMCID:PMC2749684
- Chu, K., Koob, G. F., Cole, M., Zorrilla, E. P., Roberts, A. J. Dependence-induced increases in ethanol self-administration in mice are blocked by the crf, receptor antagonist antalarmin and by crf, receptor knockout Pharmacology, Biochemistry and Behavior 2007 86:813-821 DOI:10.1016/j.pbb.2007.03.009 PMID:17482248 PMCID:PMC2170886
- Brogan, A. P., Eubanks, L. M., Koob, G. F., Dickerson, T. J., Janda, K. D. Antibody-catalyzed oxidation of delta(9)-tetrahydrocannabinol Journal of the American Chemical Society 2007 129:3698-3702 DOI:10.1021/ja070022m PMID:17335216
- Wee, S., Specio, S. E., Koob, G. F. Effects of dose and session duration on cocaine self-administration in rats Journal of Pharmacology and Experimental Therapeutics 2007 320:1134-1143 DOI:10.1124/jpet.106.113340 PMID:17202405
- O'Dell, L. E., Koob, G. F. 'Nicotine deprivation effect' in rats with intermittent 23-hour access to intravenous nicotine self-administration Pharmacology, Biochemistry and Behavior 2007 86:346-353 DOI:10.1016/j.pbb.2007.01.004 PMID:17292952 PMCID:PMC2386418
- Solbrig, M. V., Adrian, R., Wechsler, S. L., Koob, G. F. Activators of potassium m currents have anticonvulsant actions in two rat models of encephalitis European Journal of Pharmacology 2007 555:23-29 DOI:10.1016/j.ejphar.2006.10.025 PMID:17126318 PMCID:PMC2981072
- Funk, C. K., Zorrilla, E. P., Lee, M. J., Rice, K. C., Koob, G. F. Corticotropin-releasing factor 1 antagonists selectively reduce ethanol self-administration in ethanol-dependent rats Biological Psychiatry 2007 61:78-86 DOI:10.1016/j.biopsych.2006.03.063 PMID:16876134 PMCID:PMC2741496
- O'Dell, L. E., Chen, S. A., Smith, R. T., Specio, S. E., Balster, R. L., Paterson, N. E., Markou, A., Zorrilla, E. P., Koob, G. F. Extended access to nicotine self-administration leads to dependence: Circadian measures, withdrawal measures, and extinction behavior in rats Journal of Pharmacology and Experimental Therapeutics 2007 320:180-193 DOI:10.1124/jpet.106.105270 PMID:17050784
- Walker, B. M., Koob, G. F. The gamma-aminobutyric acid-b receptor agonist baclofen attenuates responding for ethanol in ethanol-dependent rats Alcoholism-Clinical and Experimental Research 2007 31:11-18 DOI:10.1111/j.1530-0277.2006.00259.x PMID:17207096 PMCID:PMC2768469
- Sabino, V., Cottone, P., Koob, G. F., Steardo, L., Lee, M. J., Rice, K. C., Zorrilla, E. P. Dissociation between opioid and crf1 antagonist sensitive drinking in sardinian alcohol-preferring rats Psychopharmacology 2006 189:175-186 DOI:10.1007/s00213-006-0546-5 PMID:17047935
- Guillem, K., Vouillac, C., Azar, M. R., Parsons, L. H., Koob, G. F., Cador, M., Stinus, L. Monoamine oxidase A rather than monoamine oxidase B inhibition increases nicotine reinforcement in rats European Journal of Neuroscience 2006 24:3532-3540 DOI:10.1111/j.1460-9568.2006.05217.x PMID:17229101
- Eubanks, L. M., Rogers, C. J., Beuscher, A. E., Koob, G. F., Olson, A. J., Dickerson, T. J., Janda, K. D. A molecular link between the active component of marijuana and Alzheimer's disease pathology Molecular Pharmaceutics 2006 3:773-777 DOI:10.1021/mp060066m PMID:17140265 PMCID:PMC2562334
- Steffensen, S. C., Stobbs, S. H., Colago, E. E. O., Lee, R. S., Koob, G. F., Gallegos, R. A., Henriksen, S. J. Contingent and non-contingent effects of heroin on mu-opioid receptor-containing ventral tegmental area gaba neurons Experimental Neurology 2006 202:139-151 DOI:10.1016/j.expneurol.2006.05.023 PMID:16814775
- Funk, C. K., O'Dell, L. E., Crawford, E. F., Koob, G. F. Corticotropin-releasing factor within the central nucleus of the amygdala mediates enhanced ethanol self-administration in withdrawn, ethanol-dependent rats Journal of Neuroscience 2006 26:11324-11332 DOI:10.1523/jneurosci.3096-06.2006 PMID:17079660
- Crabbe, J. C., Phillips, T. J., Harris, R. A., Arends, M. A., Koob, G. F. Alcohol-related genes: Contributions from studies with genetically engineered mice Addiction Biology 2006 11:195-269 DOI:10.1111/j.1369-1600.2006.00038.x PMID:16961758
- Koob, G. F. The neurobiology of addiction: A neuroadaptational view relevant for diagnosis Addiction 2006 101:23-30 DOI:10.1111/j.1360-0443.2006.01586.x PMID:16930158
- O'Dell, L. E., Bruijnzeel, A. W., Smith, R. T., Parsons, L. H., Merves, M. L., Goldberger, B. A., Richardson, H. N., Koob, G. F., Markou, A. Diminished nicotine withdrawal in adolescent rats: implications for vulnerability to addiction Psychopharmacology 2006 186:612-619 DOI:10.1007/s00213-006-0383-6 PMID:16598454
- Kenny, P. J., Chen, S. A., Kitamura, O., Markou, A., Koob, G. F. Conditioned withdrawal drives heroin consumption and decreases reward sensitivity Journal of Neuroscience 2006 26:5894-5900 DOI:10.1523/jneurosci.0740-06.2006 PMID:16738231
- Kitamura, O., Wee, S., Specio, S. E., Koob, G. F., Pulvirenti, L. Escalation of methamphetamine self-administration in rats: A dose-effect function Psychopharmacology 2006 186:48-53 DOI:10.1007/s00213-006-0353-z PMID:16552556
- Mulligan, M. K., Ponomarev, I., Hitzemann, R. J., Belknap, J. K., Tabakoff, B., Harris, R. A., Crabbe, J. C., Blednov, Y. A., Grahame, N. J., Phillips, T. J., Finn, D. A., Hoffman, P. L., et al. Toward understanding the genetics of alcohol drinking through transcriptome meta-analysis Proceedings of the National Academy of Sciences of the United States of America 2006 103:6368-6373 DOI:10.1073/pnas.0510188103 PMID:16618939 PMCID:PMC1458884
- Hoefer, M. E., Voskanian, S. J., Koob, G. F., Pulvirenti, L. Effects of terguride, ropinirole, and acetyl-l-carnitine on methamphetamine withdrawal in the rat Pharmacology, Biochemistry and Behavior 2006 83:403-409 DOI:10.1016/j.pbb.2006.02.023 PMID:16647107
- Solbrig, M. V., Adrian, R., Baratta, J., Lauterborn, J. C., Koob, G. F. Kappa opioid control of seizures produced by a virus in an animal model Brain 2006 129:642-654 DOI:10.1093/brain/awl008 PMID:16399805
- Johnson, B. A., Koob, G. F., Schuckit, M. A., Mason, B. J., Ait-Daoud, N. Understanding and treating alcohol dependence Alcoholism-Clinical and Experimental Research 2006 30:567-584 DOI:10.1111/j.1530-0277.2005.00066.x PMID:16499499
- Kranzler, H. R., Koob, G., Gastfriend, D. R., Swift, R. M., Willenbring, M. L. Advances in the pharmacotherapy of alcoholism: Challenging misconceptions Alcoholism-Clinical and Experimental Research 2006 30:272-281 DOI:10.1111/j.1530-0277.2006.00022.x PMID:16441276
- Chen, S. A., O'Dell, L. E., Hoefer, M. E., Greenwell, T. N., Zorrilla, E. P., Koob, G. F. Unlimited access to heroin self-administration: Independent motivational markers of opiate dependence Neuropsychopharmacology 2006 31:2692-2707 DOI:10.1038/sj.npp.1301008 PMID:16452
- Boutrel, B., Kenny, P. J., Specio, S. E., Martin-Fardon, R., Markou, A., Koob, G. F., de Lecea, L. Role for hypocretin in mediating stress-induced reinstatement of cocaine-seeking behavior Proceedings of the National Academy of Sciences of the United States of America 2005 102:19168-19173 DOI:10.1073/pnas.0507480102 PMID:16357203 PMCID:PMC1323172
- Tabarin, A., Chaves, Y. D., Carmona, M. D., Catargi, B., Zorrilla, E. P., Roberts, A. J., Coscina, D. V., Rousset, S., Redonnet, A., Parker, G. C., Inoue, K., Ricquier, D., et al. Resistance to diet-induced obesity in mu-opioid receptor-deficient mice: Evidence for a "thrifty gene" Diabetes 2005 54:3510-3516 DOI:10.2337/diabetes.54.12.3510 PMID:16306369
- Qi, L. W., Yamamoto, N., Meijler, M. M., Altobell, L. J., Koob, G. F., Wirsching, P., Janda, K. D. Delta(9)-tetrahydrocannabinol immunochemical studies: Haptens, monoclonal antibodies, and a convenient synthesis of radiolabeled delta(9)-tetrahydrocannabinol Journal of Medicinal Chemistry 2005 48:7389-7399 DOI:10.1021/jm050442r PMID:16279798
- Koob, G. F. The neurocircuitry of addiction: implications for treatment Clinical Neuroscience Research 2005 5:89-101 DOI:10.1016/j.cnr.2005.08.005
- Guillem, K., Vouillac, C., Azar, M. R., Parsons, L. H., Koob, G. F., Cador, M., Stinus, L. Monoamine oxidase inhibition dramatically increases the motivation to self-administer nicotine in rats Journal of Neuroscience 2005 25:8593-8600 DOI:10.1523/jneurosci.2139-05.2005 PMID:16177026
- Ahmed, S. H., Lutjens, R., van der Stap, L. D., Lekic, D., Romano-Spica, V., Morales, M., Koob, G. F., Repunte-Canonigo, V., Sanna, P. P. Gene expression evidence for remodeling of lateral hypothalamic circuitry in cocaine addiction Proceedings of the National Academy of Sciences of the United States of America 2005 102:11533-11538 DOI:10.1073/pnas.0504438102 PMID:16076954 PMCID:PMC1183574
- Valdez, G. R., Zorrilla, E. P., Koob, G. F. Homeostasis within the corticotropin-releasing factor system via crf2 receptor activation: A novel approach for the treatment of anxiety Drug Development Research 2005 65:205-215 DOI:10.1002/ddr.20024
- Izzo, E., Sanna, P. P., Koob, G. F. Impairment of dopaminergic system function after chronic treatment with corticotropin-releasing factor Pharmacology, Biochemistry and Behavior 2005 81:701-708 DOI:10.1016/j.pbb.2005.04.017 PMID:16005056
- Sanchis-Segura, C., Grisel, J. E., Olive, M. F., Ghozland, S., Koob, G. F., Roberts, A. J., Cowen, M. S. Role of the endogenous opioid system on the neuropsychopharmacological effects of ethanol: New insights about an old question Alcoholism-Clinical and Experimental Research 2005 29:1522-1527 DOI:10.1097/01.alc.0000174913.60384.e8 PMID:16156049
- O'Dell, L. E., Purdy, R. H., Covey, D. F., Richardson, H. F., Roberto, M., Koob, G. F. Epipregnanolone and a novel synthetic neuroactive steroid reduce alcohol self-administration in rats Pharmacology, Biochemistry and Behavior 2005 81:543-550 DOI:10.1016/j.pbb.2005.03.020 PMID:15950269
- Ahmed, S. H., Koob, G. F. Transition to drug addiction: A negative reinforcement model based on an allostatic decrease in reward function Psychopharmacology 2005 180:473-490 DOI:10.1007/s00213-005-2180-z PMID:15731896
- Zorrilla, E. P., Inoue, K., Fekete, E. M., Tabarin, A., Valdez, G. R., Koob, G. F. Measuring meals: Structure of prandial food and water intake of rats American Journal of Physiology-Regulatory Integrative and Comparative Physiology 2005 288:R1450-R1467 DOI:10.1152/ajpregu.00175.2004 PMID:15637168
- Kenny, P. J., Boutrel, B., Gasparini, F., Koob, G. F., Markou, A. Metabotropic glutamate 5 receptor blockade may attenuate cocaine self-administration by decreasing brain reward function in rats Psychopharmacology 2005 179:247-254 DOI:10.1007/s00213-004-2069-2 PMID:15602687
- Breese, G. R., Chu, K., Dayas, C. V., Funk, D., Knapp, D. J., Koob, G. F., Le, D. A., O'Dell, L. E., Overstreet, D. H., Roberts, A. J., Sinha, R., Valdez, G. R., et al. Stress enhancement of craving during sobriety: A risk for relapse Alcoholism-Clinical and Experimental Research 2005 29:185-195 DOI:10.1097/01.alc.0000153544.83656.3c PMID:15714042
- Stinus, L., Cador, M., Zorrilla, E. P., Koob, G. F. Buprenorphine and a crf1 antagonist block the acquisition of opiate withdrawal-induced conditioned place aversion in rats Neuropsychopharmacology 2005 30:90-98 DOI:10.1038/sj.npp.1300487 PMID:151384
- Zorrilla, E. P., Inoue, K., Valdez, G. R., Tabarin, A., Koob, G. F. Leptin and post-prandial satiety: Acute central leptin more potently reduces meal frequency than meal size in the rat Psychopharmacology 2005 177:324-335 DOI:10.1007/s00213-004-1952-1 PMID:15609069
- De Witte, P., Littleton, J., Parot, P., Koob, G. Neuroprotective and abstinence-promoting effects of acamprosate - elucidating the mechanism of action CNS Drugs 2005 19:517-537 DOI:10.2165/00023210-200519060-00004 PMID:15963001
- Valdez, G. R., Koob, G. F. Allostasis and dysregulation of corticotropin-releasing factor and neuropeptide y systems: Implications for the development of alcoholism Pharmacology, Biochemistry and Behavior 2004 79:671-689 DOI:10.1016/j.pbb.2004.09.020 PMID:15582675
- Heinrichs, S. C., Koob, G. F. Corticotropin-releasing factor in brain: A role in activation, arousal, and affect regulation Journal of Pharmacology and Experimental Therapeutics 2004 311:427-440 DOI:10.1124/jpet.103.052092 PMID:15297468
- O'Dell, L. E., Roberts, A. J., Smith, R. T., Koob, G. F. Enhanced alcohol self-administration after intermittent versus continuous alcohol vapor exposure Alcoholism-Clinical and Experimental Research 2004 28:1676-1682 DOI:10.1097/01.alc.0000145781.11923.4e PMID:15547454
- Koob, G. F. A role for gaba mechanisms in the motivational effects of alcohol Biochemical Pharmacology 2004 68:1515-1525 DOI:10.1016/j.bcp.2004.07.031 PMID:15451394
- Navarro, M., Carrera, M. R. A., del Arco, I., Trigo, J. M., Koob, G. F., de Fonseca, F. R. Cannabinoid receptor antagonist reduces heroin self-administration only in dependent rats European Journal of Pharmacology 2004 501:235-237 DOI:10.1016/j.ejphar.2004.08.022 PMID:15464083
- Martin, G., Guadano-Ferraz, A., Morte, B., Ahmed, S., Koob, G. F., de Lecea, L., Siggins, G. R. Chronic morphine treatment alters n-methyl-d-aspartate receptors in freshly isolated neurons from nucleus accumbens Journal of Pharmacology and Experimental Therapeutics 2004 311:265-273 DOI:10.1124/jpet.104.067504 PMID:15263066
- Zorrilla, E. P., Reinhardt, L. E., Valdez, G. R., Inoue, K., Rivier, J. E., Vale, W. W., Koob, G. F. Human urocortin 2, a corticotropin-releasing factor (crf)(2) agonist, and ovine crf, a crf1 agonist, differentially alter feeding and motor activity Journal of Pharmacology and Experimental Therapeutics 2004 310:1027-1034 DOI:10.1124/jpet.104.068676 PMID:15115804
- Carrera, M. R. A., Kaufmann, G. F., Mee, J. M., Meijler, M. M., Koob, G. F., Janda, K. D. Treating cocaine addiction with viruses Proceedings of the National Academy of Sciences of the United States of America 2004 101:10416-10421 DOI:10.1073/pnas.0403795101 PMID:15226496 PMCID:PMC478586
- Zorrilla, E. P., Koob, G. F. The therapeutic potential of crf1 antagonists for anxiety Expert Opinion on Investigational Drugs 2004 13:799-828 DOI:10.1517/13543784.13.7.799 PMID:15212620
- Valdez, G. R., Sabino, V., Koob, G. F. Increased anxiety-like behavior and ethanol self-administration in dependent rats: Reversal via corticotropin-releasing factor-2 receptor activation Alcoholism-Clinical and Experimental Research 2004 28:865-872 DOI:10.1097/01.alc.0000128222.29875.40 PMID:15201629
- Inoue, K., Zorrilla, E. P., Tabarin, A., Valdez, G. R., Iwasaki, S., Kiriike, N., Koob, G. F. Reduction of anxiety after restricted feeding in the rat: Implication for eating disorders Biological Psychiatry 2004 55:1075-1081 DOI:10.1016/j.biopsych.2004.01.026 PMID:15158426
- Azar, M. R., Ahmed, S. H., Lintz, R., Gutierrez, T., Stinus, L., Koob, G. F. A non-invasive gating device for continuous drug delivery that allows control over the timing and duration of spontaneous opiate withdrawal Journal of Neuroscience Methods 2004 135:129-135 DOI:10.1016/j.neumeth.2003.12.008 PMID:15020097
- Ahmed, S. H., Koob, G. F. Changes in response to a dopamine receptor antagonist in rats with escalating cocaine intake Psychopharmacology 2004 172:450-454 DOI:10.1007/s00213-003-1682-9 PMID:14647962
- Solbrig, M. V., Koob, G. F. Epilepsy, cns viral injury and dynorphin Trends in Pharmacological Sciences 2004 25:98-104 DOI:10.1016/j.tips.2003.12.010 PMID:15102496
- Carrera, M. R. A., Ashley, J. A., Hoffman, T. Z., Isomura, S., Wirsching, P., Koob, G. F., Janda, K. D. Investigations using immunization to attenuate the psychoactive effects of nicotine Bioorganic & Medicinal Chemistry 2004 12:563-570 DOI:10.1016/j.bmc.2003.11.029 PMID:14738965
- O'Dell, L. E., Alomary, A. A., Vallee, M., Koob, G. F., Fitzgerald, R. L., Purdy, R. H. Ethanol-induced increases in neuroactive steroids in the rat brain and plasma are absent in adrenalectomized and gonadectomized rats European Journal of Pharmacology 2004 484:241-247 DOI:10.1016/j.ejphar.2003.11.031 PMID:14744609
- Ben-Shahar, O., Ahmed, S. H., Koob, G. F., Ettenberg, A. The transition from controlled to compulsive drug use is associated with a loss of sensitization Brain Research 2004 995:46-54 DOI:10.1016/j.brainres.2003.09.053 PMID:14644470
- Weed, M. R., Gold, L. H., Polis, I., Koob, G. F., Fox, H. S., Taffe, M. A. Impaired performance on a rhesus monkey neuropsychological testing battery following simian immunodeficiency virus infection AIDS Research and Human Retroviruses 2004 20:77-89 DOI:10.1089/088922204322749521 PMID:15000701
- Koob, G. F., Ahmed, S. H., Boutrel, B., Chen, S. A., Kenny, P. J., Markou, A., O'Dell, L. E., Parsons, L. H., Sanna, P. P. Neurobiological mechanisms in the transition from drug use to drug dependence Neuroscience and Biobehavioral Reviews 2004 27:739-749 DOI:10.1016/j.neubiorev.2003.11.007 PMID:15019424
- Boutrel, B., Koob, G. F. What keeps us awake: The neuropharmacology of stimulants and wakefulness promoting medications Sleep 2004 27:1181-1194 PMID:15532213
- Koob, G. F. Neuroadaptive mechanisms of addiction: Studies on the extended amygdala European Neuropsychopharmacology 2003 13:442-452 DOI:10.1016/j.euroneuro.2003.08.005 PMID:14636
- Kenny, P. J., Koob, G. F., Markou, A. Conditioned facilitation of brain reward function after repeated cocaine administration Behavioral Neuroscience 2003 117:1103-1107 DOI:10.1037/0735-7044.117.5.1103 PMID:14570559
- Valdez, G. R., Zorrilla, E. P., Rivier, J., Vale, W. W., Koob, G. F. Locornotor suppressive and anxiolytic-like effects of urocortin 3, a highly selective type 2 corticotropin-releasing factor agonist Brain Research 2003 980:206-212 DOI:10.1016/s0006-8993(03)02971-8 PMID:12867260
- Heyser, C. J., Moc, K., Koob, G. F. Effects of naltrexone alone and in combination with acamprosate on the alcohol deprivation effect in rats Neuropsychopharmacology 2003 28:1463-1471 DOI:10.1038/sj.npp.1300175 PMID:1270
- Zorrilla, E. P., Tache, Y., Koob, G. F. Nibbling at crf receptor control of feeding and gastrocolonic motility Trends in Pharmacological Sciences 2003 24:421-427 DOI:10.1016/s0165-6147(03)00177-9 PMID:12915052
- Ahmed, S. H., Lin, D., Koob, G. F., Parsons, L. H. Escalation of cocaine self-administration does not depend on altered cocaine-induced nucleus accumbens dopamine levels Journal of Neurochemistry 2003 86:102-113 DOI:10.1046/j.1471-4159.2003.01833.x PMID:12807430
- Vallee, M., Purdy, R. H., Mayo, W., Koob, G. F., Le Moal, M. Neuroactive steroids: New biomarkers of cognitive aging Journal of Steroid Biochemistry and Molecular Biology 2003 85:329-335 DOI:10.1016/s0960-0760(03)00227-9 PMID:12943719
- Walker, J. R., Chen, S. A., Moffitt, H., Inturrisi, C. E., Koob, G. F. Chronic opioid exposure produces increased heroin self-administration in rats Pharmacology, Biochemistry and Behavior 2003 75:349-354 DOI:10.1016/s0091-3057(03)00094-7 PMID:12873626
- Inoue, K., Valdez, G. R., Reyes, T. M., Reinhardt, L. E., Tabarin, A., Rivier, J., Vale, W. W., Sawchenko, P. E., Koob, G. F., Zorrilla, E. P. Human urocortin ii, a selective agonist for the type 2 corticotropin-releasing factor receptor, decreases feeding and drinking in the rat Journal of Pharmacology and Experimental Therapeutics 2003 305:385-393 DOI:10.1124/jpet.102.047712 PMID:12649393
- Solbrig, M. V., Koob, G. F. Neuropharmacological sequelae of persistent cns viral infections: Lessons from borna disease virus Pharmacology, Biochemistry and Behavior 2003 74:777-787 DOI:10.1016/s0091-3057(03)00019-4 PMID:12667891
- Koob, G. F. Alcoholism: Allostasis and beyond Alcoholism-Clinical and Experimental Research 2003 27:232-243 DOI:10.1097/01.alc.0000057122.36127.c2 PMID:12605072
- Valdez, G. R., Zorrilla, E. P., Roberts, A. J., Koob, G. F. Antagonism of corticotropin-releasing factor attenuates the enhanced responsiveness to stress observed during protracted ethanol abstinence Alcohol 2003 29:55-60 DOI:10.1016/s0741-8329(03)00020-x PMID:12782246
- Caille, S., Stinus, L., Espejo, E. F., De Deurwaerdere, P., Spampinato, U., Koob, G. F. Inhibition of 5-ht neurotransmission increases clonidine protective effects on naloxone-induced conditioned place aversion in morphine-dependent rats Neuropsychopharmacology 2003 28:276-283 DOI:10.1038/sj.npp.1300033 PMID:125893
- Alomary, A. A., Vallee, M., O'Dell, L. E., Koob, G. F., Purdy, R. H., Fitzgerald, R. L. Acutely administered ethanol participates in testosterone synthesis and increases testosterone in rat brain Alcoholism-Clinical and Experimental Research 2003 27:38-43 DOI:10.1097/01.alc.0000047304.28550.4f PMID:12544003
- Koob, G. F., Roberts, A. J., Kieffer, B. L., Heyser, C. J., Katner, S. N., Ciccocioppo, R., Weiss, F. Animal models of motivation for drinking in rodents with a focus on opioid receptor neuropharmacology Recent Developments in Alcoholism 2003 16:263-281 DOI:10.1007/0-306-47939-7_19 PMID:12638642
- Kenny, P. J., Polis, I., Koob, G. F., Markou, A. Low dose cocaine self-administration transiently increases but high dose cocaine persistently decreases brain reward function in rats European Journal of Neuroscience 2003 17:191-195 DOI:10.1046/j.1460-9568.2003.02443.x PMID:12534985
- Izzo, E., Martin-Fardon, R., Koob, G. F., Weiss, F., Sanna, P. P. Neural plasticity and addiction: PI3-kinase and cocaine behavioral sensitization Nature Neuroscience 2002 5:1263-1264 DOI:10.1038/nn977 PMID:12436114
- Solbrig, M. V., Koob, G. F., Lipkin, W. I. Key role for enkephalinergic tone in cortico-striatal-thalamic function European Journal of Neuroscience 2002 16:1819-1822 DOI:10.1046/j.1460-9568.2002.02240.x PMID:12431235
- Zorrilla, E. P., Valdez, G. R., Nozulak, J., Koob, G. F., Markou, A. Effects of antalarmin, a crf type 1 receptor antagonist, on anxiety-like behavior and motor activation in the rat Brain Research 2002 952:188-199 DOI:10.1016/s0006-8993(02)03189-x PMID:12376179
- Zorrilla, E. P., Schulteis, G., Ormsby, A., Klaassen, A., Ling, N., McCarthy, J. R., Koob, G. F., De Souza, E. B. Urocortin shares the memory modulating effects of corticotropin-releasing factor (crf): Mediation by crf1 receptors Brain Research 2002 952:200-210 DOI:10.1016/s0006-8993(02)03345-0 PMID:12376180
- Valdez, G. R., Roberts, A. J., Chan, K., Davis, H., Brennan, M., Zorrilla, E. P., Koob, G. F. Increased ethanol self-administration and anxiety-like behavior during acute ethanol withdrawal and protracted abstinence: Regulation by corticotropin-releasing factor Alcoholism-Clinical and Experimental Research 2002 26:1494-1501 DOI:10.1097/01.alc.0000033120.51856.f0 PMID:12394282
- Sanna, P. P., Simpson, C., Lutjens, R., Koob, G. ERK regulation in chronic ethanol exposure and withdrawal Brain Research 2002 948:186-191 DOI:10.1016/s0006-8993(02)03191-8 PMID:12383974
- Walker, J. R., Terenius, L., Koob, G. F. Conditioned opioid withdrawal decreases nociceptin/orphanin cortex and olfactory fq levels in the frontal cortex and olfactory tubercle Neuropsychopharmacology 2002 27:203-211 DOI:10.1016/s0893-133x(02)00292-0 PMID:12093
- Vetter, D. E., Li, C. E., Zhao, L. Y., Contarino, A., Liberman, M. C., Smith, G. W., Marchuk, Y., Koob, G. F., Heinemann, S. F., Vale, W., Lee, K. F. Urocortin-deficient mice show hearing impairment and increased anxiety-like behavior Nature Genetics 2002 31:363-369 DOI:10.1038/ng914 PMID:12091910
- Valdez, G. R., Inoue, K., Koob, G. F., Rivier, J., Vale, W., Zorrilla, E. P. Human urocortin ii: Mild locomotor suppressive and delayed anxiolytic-like effects of a novel corticotropin-releasing factor related peptide Brain Research 2002 943:142-150 DOI:10.1016/s0006-8993(02)02707-5 PMID:12088848
- Caille, S., Espejo, E. F., Koob, G. F., Stinus, L. Dorsal and median raphe serotonergic system lesion does not alter the opiate withdrawal syndrome Pharmacology, Biochemistry and Behavior 2002 72:979-986 DOI:10.1016/s0091-3057(02)00810-9 PMID:12062589
- Contarino, A., Picetti, R., Matthes, H. W., Koob, G. F., Kieffer, B. L., Gold, L. H. Lack of reward and locomotor stimulation induced by heroin in mu-opioid receptor-deficient mice European Journal of Pharmacology 2002 446:103-109 DOI:10.1016/s0014-2999(02)01812-5 PMID:12098591
- Smith, A. D., Amalric, M., Koob, G. F., Zigmond, M. J. Effect of bilateral 6-hydroxydopamine lesions of the medial forebrain bundle on reaction time Neuropsychopharmacology 2002 26:756-764 DOI:10.1016/s0893-133x(01)00420-1 PMID:12007
- Ryabinin, A. E., Bachtell, R. K., Heinrichs, S. C., Lee, S., Rivier, C., Olive, M. F., Mehmert, K. K., Camarini, R., Kim, J. A., Koenig, H. N., Nannini, M. A., Hodge, C. W., et al. The corticotropin-releasing factor/urocortin system and alcohol Alcoholism-Clinical and Experimental Research 2002 26:714-722 DOI:10.1111/j.1530-0277.2002.tb02596.x PMID:12045481
- Pulvirenti, L., Koob, G. F. Being partial to psychostimulant addiction therapy Trends in Pharmacological Sciences 2002 23:151-153 DOI:10.1016/s0165-6147(00)01991-x PMID:11931978
- Hungund, B. L., Basavarajappa, B. S., Vadasz, C., Kunos, G., de Fonseca, F. R., Colombo, G., Serra, S., Parsons, L., Koob, G. F. Ethanol, endocannabinoids, and the cannabinoidergic signaling system Alcoholism-Clinical and Experimental Research 2002 26:565-574 DOI:10.1111/j.1530-0277.2002.tb02575.x PMID:11981134
- Koob, G. F., Mason, B. J., De Witte, P., Littleton, J., Siggins, G. R. Potential neuroprotective effects of acamprosate Alcoholism-Clinical and Experimental Research 2002 26:586-592 DOI:10.1111/j.1530-0277.2002.tb02578.x PMID:11981137
- Spina, M. G., Merlo-Pich, E., Akwa, Y., Balducci, C., Basso, A. M., Zorrilla, E. P., Britton, K. T., Rivier, J., Vale, W. W., Koob, G. F. Time-dependent induction of anxiogenic-like effects after central infusion of urocortin or corticotropin-releasing factor in the rat Psychopharmacology 2002 160:113-121 DOI:10.1007/s00213-001-0940-y PMID:11875628
- Orsini, C., Izzo, E., Koob, G. F., Pulvirenti, L. Blockade of nitric oxide synthesis reduces responding for cocaine self-administration during extinction and reinstatement Brain Research 2002 925:133-140 DOI:10.1016/s0006-8993(01)03267-x PMID:11792361
- Bale, T. L., Picetti, R., Contarino, A., Koob, G. F., Vale, W. W., Lee, K. F. Mice deficient for both corticotropin-releasing factor receptor 1 (crfr1) and crfr2 have an impaired stress response and display sexually dichotomous anxiety-like behavior Journal of Neuroscience 2002 22:193-199 PMID:11756502
- Ahmed, S. H., Kenny, P. J., Koob, G. F., Markou, A. Neurobiological evidence for hedonic allostasis associated with escalating cocaine use Nature Neuroscience 2002 5:625-626 DOI:10.1038/nn872 PMID:12055635
- Vallee, M., Shen, W., Heinrichs, S. C., Zorumski, C. F., Covey, D. F., Koob, G. F., Purdy, R. H. Steroid structure and pharmacological properties determine the anti-amnesic effects of pregnenolone sulphate in the passive avoidance task in rats European Journal of Neuroscience 2001 14:2003-2010 DOI:10.1046/j.0953-816x.2001.01817.x PMID:11860495
- Orsini, C., Koob, G. F., Pulvirenti, L. Dopamine partial agonist reverses amphetamine withdrawal in rats Neuropsychopharmacology 2001 25:789-792 DOI:10.1016/s0893-133x(01)00270-6 PMID:11682
- Currie, P. J., Coscina, D. V., Bishop, C., Coiro, C. D., Koob, G. F., Rivier, J., Vale, W. Hypothalamic paraventricular nucleus injections of urocortin alter food intake and respiratory quotient Brain Research 2001 916:222-228 DOI:10.1016/s0006-8993(01)02851-7 PMID:11597609
- Roberts, A. J., Gold, L. H., Polis, L., McDonald, J. S., Filliol, D., Kieffer, B. L., Koob, G. F. Increased ethanol self-administration in delta-opioid receptor knockout mice Alcoholism-Clinical and Experimental Research 2001 25:1249-1256 DOI:10.1111/j.1530-0277.2001.tb02344.x PMID:11584142
- Navarro, M., Carrera, M. R. A., Fratta, W., Valverde, O., Cossu, G., Fattore, L., Chowen, J. A., Gomez, R., del Arco, I., Villanua, M. A., Maldonado, R., Koob, G. F., et al. Functional interaction between opioid and cannabinoid receptors in drug self-administration Journal of Neuroscience 2001 21:5344-5350 PMID:11438610
- Zorrilla, E. P., Schulteis, G., Ling, N., Koob, G. F., De Souza, E. B. Performance-enhancing effects of crf-bp ligand inhibitors Neuroreport 2001 12:1231-1234 DOI:10.1097/00001756-200105080-00035 PMID:11338197
- Le, A. D., Kiianmaa, K., Cunningham, C. L., Engel, J. A., Ericson, M., Soderpalm, B., Koob, G. F., Roberts, A. J., Weiss, F., Hyytia, P., Janhunen, S., Mikkola, J., et al. Neurobiological processes in alcohol addiction Alcoholism-Clinical and Experimental Research 2001 25:144S-151S DOI:10.1111/j.1530-0277.2001.tb02389.x PMID:11391064
- Izzo, E., Orsini, C., Koob, G. F., Pulvirenti, L. A dopamine partial agonist and antagonist block amphetamine self-administration in a progressive ratio schedule Pharmacology, Biochemistry and Behavior 2001 68:701-708 DOI:10.1016/s0091-3057(01)00472-5 PMID:11526967
- Macey, D. J., Froestl, W., Koob, G. F., Markou, A. Both gaba(b) receptor agonist and antagonists decreased brain stimulation reward in the rat Neuropharmacology 2001 40:676-685 DOI:10.1016/s0028-3908(00)00204-5 PMID:11311895
- David, V., Gold, L. H., Koob, G. F., Cazala, P. Anxiogenic-like effects limit rewarding effects of cocaine in balb/cbyj mice Neuropsychopharmacology 2001 24:300-318 DOI:10.1016/s0893-133x(00)00205-0 PMID:11166
- Carrera, M. R. A., Ashley, J. A., Wirsching, P., Koob, G. F., Janda, K. D. A second-generation vaccine protects against the psychoactive effects of cocaine Proceedings of the National Academy of Sciences of the United States of America 2001 98:1988-1992 DOI:10.1073/pnas.041610998 PMID:11172063
- Koob, G. F., Le Moal, M. Drug addiction, dysregulation of reward, and allostasis Neuropsychopharmacology 2001 24:97-129 DOI:10.1016/s0893-133x(00)00195-0 PMID:111203
- Gracy, K. N., Dankiewicz, L. A., Koob, G. F. Opiate withdrawal-induced fos immunoreactivity in the rat extended amygdala parallels the development of conditioned place aversion Neuropsychopharmacology 2001 24:152-160 DOI:10.1016/s0893-133x(00)00186-x PMID:11120
- Weiss, F., Koob, G. F. Drug addiction: Functional neurotoxicity of the brain reward systems Neurotoxicity Research 2001 3:145-156 DOI:10.1007/bf03033235 PMID:15111266
- Koob, G., Bartfai, T., Roberts, A. J. Molecular genetic approaches to the neuropharmacology of corticotropin releasing factor International Journal of Comparative Psychology 2001 14:90-110
- Vallee, M., Mayo, W., Koob, G. F., Le Moal, M. Neurosteroids in learning and memory processes Neurosteroids and Brain Function 2001 46:273-320 PMID:11599303
- Richter, R. M., Zorrilla, E. P., Basso, A. M., Koob, G. F., Weiss, F. Altered amygdalar crf release and increased anxiety-like behavior in sardinian alcohol-preferring rats: A microdialysis and behavioral study Alcoholism-Clinical and Experimental Research 2000 24:1765-1772 DOI:10.1111/j.1530-0277.2000.tb01979.x PMID:11141034
- Vallee, M., Rivera, J. D., Koob, G. F., Purdy, R. H., Fitzgerald, R. L. Quantification of neurosteroids in rat plasma and brain following swim stress and allopregnanolone administration using negative chemical ionization gas chromatography/mass spectrometry Analytical Biochemistry 2000 287:153-166 DOI:10.1006/abio.2000.4841 PMID:11078595
- Solbrig, M. V., Koob, G. F., Parsons, L. H., Kadota, T., Horscroft, N., Briese, T., Lipkin, W. I. Neurotrophic factor expression after CNS viral injury produces enhanced sensitivity to psychostimulants: potential mechanism for addiction vulnerability Journal of Neuroscience 2000 20:RC104 PMID:11050146
- Koob, G. Drug addiction Neurobiology of Disease 2000 7:543-545 DOI:10.1006/nbdi.2000.0351 PMID:11042073
- Koob, G. F. Animal models of craving for ethanol Addiction 2000 95:73-81 DOI:10.1046/j.1360-0443.95.8s2.17.x PMID:11002904
- Morse, A. C., Schulteis, G., Holloway, F. A., Koob, G. F. Conditioned place aversion to the "hangover" phase of acute ethanol administration in the rat Alcohol 2000 22:19-24 DOI:10.1016/s0741-8329(00)00099-9 PMID:11109024
- Contarino, A., Dellu, F., Koob, G. F., Smith, G. W., Lee, K. F., Vale, W. W., Gold, L. H. Dissociation of locomotor activation and suppression of food intake induced by crf in crfr1-deficient mice Endocrinology 2000 141:2698-2702 DOI:10.1210/en.141.7.2698 PMID:10875276
- Schulteis, G., Ahmed, S. H., Morse, A. C., Koob, G. F., Everitt, B. J. Conditioning and opiate withdrawal Nature 2000 405:1013-1014 PMID:10890431
- Macey, D. J., Koob, G. F., Markou, A. Crf and urocortin decreased brain stimulation reward in the rat: Reversal by a crf receptor antagonist Brain Research 2000 866:82-91 DOI:10.1016/s0006-8993(00)02229-0 PMID:10825483
- Roberts, A. J., Heyser, C. J., Cole, M., Griffin, P., Koob, G. F. Excessive ethanol drinking following a history of dependence: Animal model of allostasis Neuropsychopharmacology 2000 22:581-594 DOI:10.1016/s0893-133x(99)00167-0 PMID:10788
- Roberts, A. J., McDonald, J. S., Heyser, C. J., Kieffer, B. L., Matthes, H. W. D., Koob, G. F., Gold, L. H. Mu-opioid receptor knockout mice do not self-administer alcohol Journal of Pharmacology and Experimental Therapeutics 2000 293:1002-1008 PMID:10869404
- Carrera, M. R. A., Ashley, J. A., Zhou, B., Wirsching, P., Koob, G. F., Janda, K. D. Cocaine vaccines: Antibody protection against relapse in a rat model Proceedings of the National Academy of Sciences of the United States of America 2000 97:6202-6206 DOI:10.1073/pnas.97.11.6202 PMID:10823960
- Bale, T. L., Contarino, A. B., Smith, G. W., Chan, R., Gold, L. H., Sawchenko, P. E., Koob, G. F., Vale, W. W., Lee, K. F. Mice deficient for corticotropin-releasing hormone receptor-2 display anxiety-like behaviour and are hypersensitive to stress Nature Genetics 2000 24:410-414 PMID:10742108
- Stinus, L., Caille, S., Koob, G. F. Opiate withdrawal-induced place aversion lasts for up to 16 weeks Psychopharmacology 2000 149:115-120 DOI:10.1007/s002139900358 PMID:10805605
- Ahmed, S. H., Walker, J. R., Koob, G. F. Persistent increase in the motivation to take heroin in rats with a history of drug escalation Neuropsychopharmacology 2000 22:413-421 DOI:10.1016/s0893-133x(99)00133-5 PMID:107006
- Spina, M. G., Basso, A. M., Zorrilla, E. P., Heyser, C. J., Rivier, J., Vale, W., Merlo-Pich, E., Koob, G. F. Behavioral effects of central administration of the novel crf antagonist astressin in rats Neuropsychopharmacology 2000 22:230-239 DOI:10.1016/s0893-133x(99)00108-6 PMID:10693
- Smith, A. D., Smith, D. L., Zigmond, M. J., Amalric, M., Koob, G. F. Differential effects of dopamine receptor subtype blockade on performance of rats in a reaction-time paradigm Psychopharmacology 2000 148:355-360 DOI:10.1007/s002130050063 PMID:10928307
- Gracy, K. N., Dankiewicz, L. A., Weiss, F., Koob, G. F. Heroin-specific stimuli reinstate operant heroin-seeking behavior in rats after prolonged extinction Pharmacology, Biochemistry and Behavior 2000 65:489-494 DOI:10.1016/s0091-3057(99)00234-8 PMID:10683489
- Watkins, S. S., Stinus, L., Koob, G. F., Markou, A. Reward and somatic changes during precipitated nicotine withdrawal in rats: Centrally and peripherally mediated effects Journal of Pharmacology and Experimental Therapeutics 2000 292:1053-1064 PMID:10688623
- Lin, D., Koob, G. F., Markou, A. Time-dependent alterations in icss thresholds associated with repeated amphetamine administrations Pharmacology, Biochemistry and Behavior 2000 65:407-417 DOI:10.1016/s0091-3057(99)00213-0 PMID:10683480
- Walker, J. R., Ahmed, S. H., Gracy, K. N., Koob, G. F. Microinjections of an opiate receptor antagonist into the bed nucleus of the stria terminalis suppress heroin self-administration in dependent rats Brain Research 2000 854:85-92 DOI:10.1016/s0006-8993(99)02288-x PMID:10784110
- Dellu, F., Contarino, A., Simon, H., Koob, G. F., Gold, L. H. Genetic differences in response to novelty and spatial memory using a two-trial recognition task in mice Neurobiology of Learning and Memory 2000 73:31-48 DOI:10.1006/nlme.1999.3919 PMID:10686122
- Britton, K. T., Akwa, Y., Spina, M. G., Koob, G. F. Neuropeptide y blocks anxiogenic-like behavioral action of corticotropin-releasing factor in an operant conflict test and elevated plus maze Peptides 2000 21:37-44 DOI:10.1016/s0196-9781(99)00169-2 PMID:10704717
- Baldo, B. A., Koob, G. F., Markou, A. Role of adenosine a2 receptors in brain stimulation reward under baseline conditions and during cocaine withdrawal in rats Journal of Neuroscience 1999 19:11017-11026 PMID:10594082
- Roberts, A., Heyser, C., Koob, G. Blood alcohol concentrations in rats drinking or intubated with ethanol. Response Alcoholism-Clinical and Experimental Research 1999 23:1946-1947 DOI:10.1111/j.1530-0277.1999.tb04098.x PMID:10630615
- Akwa, Y., Purdy, R. H., Koob, G. F., Britton, K. T. The amygdala mediates the anxiolytic-like effect of the neurosteroid allopregnanolone in rat Behavioural Brain Research 1999 106:119-125 DOI:10.1016/s0166-4328(99)00101-1 PMID:10595427
- Koob, G. F. Corticotropin-releasing factor, norepinephrine, and stress Biological Psychiatry 1999 46:1167-1180 DOI:10.1016/s0006-3223(99)00164-x PMID:10560023
- Walker, J. R., King, M., Izzo, E., Koob, G. F., Pasternak, G. W. Antagonism of heroin and morphine self-administration in rats by the morphine-6 beta-glucuronide antagonist 3-o-methylnaltrexone European Journal of Pharmacology 1999 383:115-119 DOI:10.1016/s0014-2999(99)00633-0 PMID:10585524
- Weed, M. R., Taffe, M. A., Polis, I., Roberts, A. C., Robbins, T. W., Koob, G. F., Bloom, F. E., Gold, L. H. Performance norms for a rhesus monkey neuropsychological testing battery: acquisition and long-term performance Cognitive Brain Research 1999 8:185-201 DOI:10.1016/s0926-6410(99)00020-8 PMID:10556598
- Martin, G., Ahmed, S. H., Blank, T., Spiess, J., Koob, G. F., Siggins, G. R. Chronic morphine treatment alters nmda receptor-mediated synaptic transmission in the nucleus accumbens Journal of Neuroscience 1999 19:9081-9089 PMID:10516325
- Ahmed, S. H., Koob, G. F. Long-lasting increase in the set point for cocaine self-administration after escalation in rats Psychopharmacology 1999 146:303-312 DOI:10.1007/s002130051121 PMID:10541731
- Heyser, C. J., Roberts, A. J., Schulteis, G., Koob, G. F. Central administration of an opiate antagonist decreases oral ethanol self-administration in rats Alcoholism-Clinical and Experimental Research 1999 23:1468-1476 DOI:10.1097/00000374-199909000-00008 PMID:10512312
- Lin, D., Koob, G. F., Markou, A. Differential effects of withdrawal from chronic amphetamine or fluoxetine administration on brain stimulation reward in the rat - interactions between the two drugs Psychopharmacology 1999 145:283-294 DOI:10.1007/s002130051060 PMID:10494577
- Caille, S., Espejo, E. F., Reneric, J. P., Cador, M., Koob, G. F., Stinus, L. Total neurochemical lesion of noradrenergic neurons of the locus ceruleus does not alter either naloxone-precipitated or spontaneous opiate withdrawal nor does it influence ability of clonidine to reverse opiate withdrawal Journal of Pharmacology and Experimental Therapeutics 1999 290:881-892 PMID:10411605
- Contarino, A., Dellu, F., Koob, G. F., Smith, G. W., Lee, K. F., Vale, W., Gold, L. H. Reduced anxiety-like and cognitive performance in mice lacking the corticotropin-releasing factor receptor 1 Brain Research 1999 835:1-9 DOI:10.1016/s0006-8993(98)01158-5 PMID:10448190
- Lee, R. S., Criado, J. R., Koob, G. F., Henriksen, S. J. Cellular responses of nucleus accumbens neurons to opiate-seeking behavior: I. Sustained responding during heroin self-administration Synapse 1999 33:49-58 DOI:10.1002/(sici)1098-2396(199907)33:1<49::aid-syn5>3.0.co;2-o PMID:10380850
- Basso, A. M., Spina, M., Rivier, J., Vale, W., Koob, G. F. Corticotropin-releasing factor antagonist attenuates the "anxiogenic-like" effect in the defensive burying paradigm but not in the elevated plus-maze following chronic cocaine in rats Psychopharmacology 1999 145:21-30 DOI:10.1007/s002130051028 PMID:10445369
- Roberts, A. J., Heyser, C. J., Koob, G. F. Operant self-administration of sweetened versus unsweetened ethanol: effects on blood alcohol levels Alcoholism-Clinical and Experimental Research 1999 23:1151-1157 DOI:10.1097/00000374-199907000-00003 PMID:10443980
- Criado, J. R., Li, H. T., Jiang, X. H., Spina, M., Huitron-Resendiz, S., Liapakis, G., Calbet, M., Siehler, S., Henriksen, S. J., Koob, G., Hoyer, D., Sutcliffe, J. G., et al. Structural and compositional determinants of cortistatin activity Journal of Neuroscience Research 1999 56:611-619 DOI:10.1002/(sici)1097-4547(19990615)56:6<611::aid-jnr7>3.0.co;2-g PMID:10374816
- Schulteis, G., Heyser, C. J., Koob, G. F. Differential expression of response-disruptive and somatic indices of opiate withdrawal during the initiation and development of opiate dependence Behavioural Pharmacology 1999 10:235-242 PMID:10780239
- Carrera, M. R. A., Schulteis, G., Koob, G. F. Heroin self-administration in dependent wistar rats: Increased sensitivity to naloxone Psychopharmacology 1999 144:111-120 DOI:10.1007/s002130050983 PMID:10394991
- Parsons, L. H., Koob, G. F., Weiss, F. RU 24969, a 5-HT1B/1A receptor agonist, potentiates cocaine-induced increases in nucleus accumbens dopamine Synapse 1999 32:132-135 DOI:10.1002/(sici)1098-2396(199905)32:2<132::aid-syn6>3.0.co;2-v PMID:10231132
- Baldo, B. A., Jain, K., Veraldi, L., Koob, G. F., Markou, A. A dopamine d-1 agonist elevates self-stimulation thresholds: Comparison to other dopamine-selective drugs Pharmacology, Biochemistry and Behavior 1999 62:659-672 DOI:10.1016/s0091-3057(98)00206-8 PMID:10208371
- Watkins, S. S., Epping-Jordan, M. P., Koob, G. F., Markou, A. Blockade of nicotine self-administration with nicotinic antagonists in rats Pharmacology, Biochemistry and Behavior 1999 62:743-751 DOI:10.1016/s0091-3057(98)00226-3 PMID:10208381
- Leshner, A. I., Koob, G. F. Drugs of abuse and the brain Proceedings of the Association of American Physicians 1999 111:99-108 DOI:10.1046/j.1525-1381.1999.09218.x PMID:10220804
- Koob, G. F., Heinrichs, S. C. A role for corticotropin releasing factor and urocortin in behavioral responses to stressors Brain Research 1999 848:141-152 DOI:10.1016/s0006-8993(99)01991-5 PMID:10612706
- Koob, G. F., Weiss, F., Tiffany, S. T., Zieglgansberger, W., Spanagel, R. Animal models of craving: a roundtable discussion Alcohol Research and Health 1999 23:233-236 PMID:10890819
- Koob, G. F., Roberts, A. J. Brain reward circuits in alcoholism CNS Spectrums 1999 4:23-37
- Rodrigquez De Fonseca, F., Roberts, A. J., Bilbao, A., Koob, G. F., Navarro, M. Cannabinoid receptor antagonist SR141716a decreases operant ethanol self administration in rats exposed to ethanol-vapor chambers Acta Pharmacologica Sinica 1999 20:1109-1114 PMID:11189201
- Baldo, B. A., Markou, A., Koob, G. F. Increased sensitivity to the locomotor depressant effect of a dopamine receptor antagonist during cocaine withdrawal in the rat Psychopharmacology 1999 141:135-144 DOI:10.1007/s002130050817 PMID:9952037
- Harrison, A. A., Parsons, L. H., Koob, G. F., Markou, A. RU 24969, a 5-HT1A/1B agonist, elevates brain stimulation reward thresholds: an effect reversed by GR 127935, a 5-HT1B/1D antagonist Psychopharmacology 1999 141:242-250 DOI:10.1007/s002130050831 PMID:10027505
- Kimes, A. S., Maldonado, R., Ambrosio, E., Koob, G. F., London, E. D. Cerebral glucose metabolism during opioid withdrawal following methylnaloxonium injection into the locus coeruleus Brain Research 1998 814:1-12 DOI:10.1016/s0006-8993(98)00813-0 PMID:9838021
- Kosten, T. R., Markou, A., Koob, G. F. Depression and stimulant dependence - neurobiology and pharmacotherapy Journal of Nervous and Mental Disease 1998 186:737-745 DOI:10.1097/00005053-199812000-00001 PMID:9865811
- Parsons, L. H., Weiss, F., Koob, G. F. Serotonin(1B) receptor stimulation enhances cocaine reinforcement Journal of Neuroscience 1998 18:10078-10089 PMID:9822762
- Navarro, M., Chowen, J., Carrera, M. R. A., del Arco, I., Villanua, M. A., Martin, Y., Roberts, A. J., Koob, G. F., de Fonseca, F. R. Cb1 cannabinoid receptor antagonist-induced opiate withdrawal in morphine-dependent rats Neuroreport 1998 9:3397-3402 DOI:10.1097/00001756-199810260-00012 PMID:9855288
- Ahmed, S. H., Koob, G. F. Transition from moderate to excessive drug intake: Change in hedonic set point Science 1998 282:298-300 DOI:10.1126/science.282.5387.298 PMID:9765157
- Roberts, A. J., Smith, A. D., Weiss, F., Rivier, C., Koob, G. F. Estrous cycle effects on operant responding for ethanol in female rats Alcoholism-Clinical and Experimental Research 1998 22:1564-1569 DOI:10.1097/00000374-199810000-00028 PMID:9802543
- Pulvirenti, L., Balducci, C., Piercy, M., Koob, G. F. Characterization of the effects of the partial dopamine agonist terguride on cocaine self-administration in the rat Journal of Pharmacology and Experimental Therapeutics 1998 286:1231-1238 PMID:9732383
- Koob, G. F., Sanna, P. P., Bloom, F. E. Neuroscience of addiction Neuron 1998 21:467-476 DOI:10.1016/s0896-6273(00)80557-7 PMID:9768834
- Eckardt, M. J., File, S. E., Gessa, G. L., Grant, K. A., Guerri, C., Hoffman, P. L., Kalant, H., Koob, G. F., Li, T. K., Tabakoff, B. Effects of moderate alcohol consumption on the central nervous system Alcoholism-Clinical and Experimental Research 1998 22:998-1040 DOI:10.1111/j.1530-0277.1998.tb03695.x PMID:9726269
- Lee, R. S., Koob, G. F., Henriksen, S. J. Electrophysiological responses of nucleus accumbens neurons to novelty stimuli and exploratory behavior in the awake, unrestrained rat Brain Research 1998 799:317-322 DOI:10.1016/s0006-8993(98)00477-6 PMID:9675326
- Walker, J. R., Spina, M., Terenius, L., Koob, G. F. Nociceptin fails to affect heroin self-administration in the rat Neuroreport 1998 9:2243-2247 DOI:10.1097/00001756-199807130-00017 PMID:9694207
- Schulteis, G., Yackey, M., Risbrough, V., Koob, G. F. Anxiogenic-like effects of spontaneous and naloxone-precipitated opiate withdrawal in the elevated plus-maze Pharmacology, Biochemistry and Behavior 1998 60:727-731 DOI:10.1016/s0091-3057(98)00034-3 PMID:9678657
- Smith, G. W., Aubry, J. M., Dellu, F., Contarino, A., Bilezikjian, L. M., Gold, L. H., Chen, R. P., Marchuk, Y., Hauser, C., Bentley, C. A., Sawchenko, P. E., Koob, G. F., et al. Corticotropin releasing factor receptor 1-deficient mice display decreased anxiety, impaired stress response, and aberrant neuroendocrine development Neuron 1998 20:1093-1102 DOI:10.1016/s0896-6273(00)80491-2 PMID:9655498
- Kreek, M. J., Koob, G. F. Drug dependence: Stress and dysregulation of brain reward pathways Drug and Alcohol Dependence 1998 51:23-47 DOI:10.1016/s0376-8716(98)00064-7 PMID:9716928
- Epping-Jordan, M. P., Watkins, S. S., Koob, G. F., Markou, A. Dramatic decreases in brain reward function during nicotine withdrawal Nature 1998 393:76-79 PMID:9590692
- Roberts, A. J., McArthur, R. A., Hull, E. E., Post, C., Koob, G. F. Effects of amperozide, 8-OH-DPAT, and FG 5974 on operant responding for ethanol Psychopharmacology 1998 137:25-32 DOI:10.1007/s002130050589 PMID:9631953
- Raber, J., Sorg, O., Horn, T. F. W., Yu, N., Koob, G. F., Campbell, I. L., Bloom, F. E. Inflammatory cytokines: Putative regulators of neuronal and neuro-endocrine function Brain Research Reviews 1998 26:320-326 DOI:10.1016/s0165-0173(97)00041-6 PMID:9651548
- Solbrig, M. V., Koob, G. F., Lipkin, W. I. Cocaine sensitivity in borna disease virus-infected rats Pharmacology, Biochemistry and Behavior 1998 59:1047-1052 DOI:10.1016/s0091-3057(97)00507-8 PMID:9586866
- Heinrichs, S. C., Klaassen, A., Koob, G. F., Schulteis, G., Ahmed, S., De Souza, E. B. Corticotropin-releasing factor receptor blockade enhances conditioned aversive properties of cocaine in rats Psychopharmacology 1998 136:247-255 DOI:10.1007/s002130050563 PMID:9566810
- Markou, A., Kosten, T. R., Koob, G. F. Neurobiological similarities in depression and drug dependence: A self-medication hypothesis Neuropsychopharmacology 1998 18:135-174 DOI:10.1016/s0893-133x(97)00113-9 PMID:94711
- Koob, G. F., Rocio, M., Carrera, A., Gold, L. H., Heyser, C. J., Maldonado-Irizarry, C., Markou, A., Parsons, L. H., Roberts, A. J., Schulteis, G., Stinus, L., Walker, J. R., et al. Substance dependence as a compulsive behavior Journal of Psychopharmacology 1998 12:39-48 DOI:10.1177/026988119801200106 PMID:9584967
- Epping-Jordan, M. P., Markou, A., Koob, G. F. The dopamine d-1 receptor antagonist sch 23390 injected into the dorsolateral bed nucleus of the stria terminalis decreased cocaine reinforcement in the rat Brain Research 1998 784:105-115 DOI:10.1016/s0006-8993(97)01190-6 PMID:9518570
- Heyser, C. J., Schulteis, G., Durbin, P., Koob, G. F. Chronic acamprosate eliminates the alcohol deprivation effect while having limited effects on baseline responding for ethanol in rats Neuropsychopharmacology 1998 18:125-133 DOI:10.1016/s0893-133x(97)00130-9 PMID:94301
- Koob, G. F., Roberts, A. J., Schulteis, G., Parsons, L. H., Heyser, C. J., Hyytia, P., Merlo-Pich, E., Weiss, F. Neurocircuitry targets in ethanol reward and dependence Alcoholism-Clinical and Experimental Research 1998 22:3-9 DOI:10.1097/00000374-199802000-00001 PMID:9514280
- Schulteis, G., Stinus, L., Risbrough, V. B., Koob, G. F. Clonidine blocks acquisition but not expression of conditioned opiate withdrawal in rats Neuropsychopharmacology 1998 19:406-416 DOI:10.1016/s0893-133x(98)00036-0 PMID:97786
- Heinrichs, S. C., Menzaghi, F., Koob, G. F. Neuropeptide y-induced feeding and its control Vitamins and Hormones 1998 54:51-66 PMID:9529973
- Koob, G. F., LeMoal, M. Drug abuse: Hedonic homeostatic dysregulation Science 1997 278:52-58 DOI:10.1126/science.278.5335.52 PMID:9311926
- Ahmed, S. H., Koob, G. F. Cocaine but not food-seeking behavior is reinstated by stress after extinction Psychopharmacology 1997 132:289-295 DOI:10.1007/s002130050347 PMID:9292629
- Brot, M. D., Rall, G. F., Oldstone, M. B. A., Koob, G. F., Gold, L. H. Deficits in discriminated learning remain despite clearance of long-term persistent viral infection in mice Journal of Neurovirology 1997 3:265-273 PMID:9291234
- Heyser, C. J., Schulteis, G., Koob, G. F. Increased ethanol self-administration after a period of imposed ethanol deprivation in rats trained in a limited access paradigm Alcoholism-Clinical and Experimental Research 1997 21:784-791 DOI:10.1097/00000374-199708000-00004 PMID:9267526
- Caine, S. B., Koob, G. F., Parsons, L. H., Everitt, B. J., Schwartz, J. C., Sokoloff, P. D3 receptor test in vitro predicts decreased cocaine self-administration in rats Neuroreport 1997 8:2373-2377 DOI:10.1097/00001756-199707070-00054 PMID:9243643
- Britton, K. T., Southerland, S., VanUden, E., Kirby, D., Rivier, J., Koob, G. Anxiolytic activity of npy receptor agonists in the conflict test Psychopharmacology 1997 132:6-13 DOI:10.1007/s002130050313 PMID:9272753
- Deroche, V., Caine, S. B., Heyser, C. J., Polis, I., Koob, G. F., Gold, L. H. Differences in the liability to self-administer intravenous cocaine between c57bl/6xsjl and balb/cbyj mice Pharmacology, Biochemistry and Behavior 1997 57:429-440 DOI:10.1016/s0091-3057(96)00439-x PMID:9218267
- Koob, G. F., Caine, S. B., Parsons, L., Markou, A., Weiss, F. Opponent process model and psychostimulant addiction Pharmacology, Biochemistry and Behavior 1997 57:513-521 DOI:10.1016/s0091-3057(96)00438-8 PMID:9218276
- Heyser, C. J., McDonald, J. S., Beauchamp, V., Koob, G. F., Gold, L. H. The effects of cocaine on operant responding for food in several strains of mice Psychopharmacology 1997 132:202-208 DOI:10.1007/s002130050337 PMID:9266618
- deFonseca, F. R., Carrera, M. R. A., Navarro, M., Koob, G. F., Weiss, F. Activation of corticotropin-releasing factor in the limbic system during cannabinoid withdrawal Science 1997 276:2050-2054 PMID:9197270
- Brot, M. D., Akwa, Y., Purdy, R. H., Koob, G. F., Britton, K. T. The anxiolytic-like effects of the neurosteroid allopregnanolone: Interactions with gaba(a) receptors European Journal of Pharmacology 1997 325:1-7 DOI:10.1016/s0014-2999(97)00096-4 PMID:9151931
- Raber, J., Koob, G. F., Bloom, F. E. Interferon-alpha and transforming growth factor-beta(1) regulate corticotropin-releasing factor release from the amygdala: Comparison with the hypothalamic response Neurochemistry International 1997 30:455-463 DOI:10.1016/s0197-0186(96)00082-4 PMID:9106261
- Pulvirenti, L., Balducci, C., Koob, G. F. Dextromethorphan reduces intravenous cocaine self-administration in the rat European Journal of Pharmacology 1997 321:279-283 DOI:10.1016/s0014-2999(96)00970-3 PMID:9085038
- de Fonseca, F. R., Navarro, M., Carrera, M. R. A., Koob, G. F., Weiss, F. Marijuana addiction: Response Science 1997 277:751-752 DOI:10.1126/science.277.5327.749a
- Schulteis, G., Heyser, C. J., Koob, G. F. Opiate withdrawal signs precipitated by naloxone following a single exposure to morphine: Potentiation with a second morphine exposure Psychopharmacology 1997 129:56-65 DOI:10.1007/s002130050162 PMID:9122364
- Schulteis, G., Gold, L. H., Koob, G. F. Preclinical behavioral models for addressing unmet needs in opiate addiction Seminars in Neuroscience 1997 9:94-109 DOI:10.1006/smns.1997.0110
- Roberts, A. J., Koob, G. F. The neurobiology of addiction: an overview Alcohol Health and Research World 1997 21:101-106 PMID:15704343
- Koob, G. F., Nestler, E. J. The neurobiology of drug addiction Journal of Neuropsychiatry and Clinical Neurosciences 1997 9:482-497 PMID:9276849
- Parsons, L. H., Koob, G. F., Weiss, F. Extracellular serotonin is decreased in the nucleus accumbens during withdrawal from cocaine self-administration Behavioural Brain Research 1996 73:225-228 DOI:10.1016/0166-4328(96)00101-5 PMID:8788507
- ProsperoGarcia, O., Gold, L. H., Fox, H. S., Polis, I., Koob, G. F., Bloom, F. E., Henriksen, S. J. Microglia-passaged simian immunodeficiency virus induces neurophysiological abnormalities in monkeys Proceedings of the National Academy of Sciences of the United States of America 1996 93:14158-14163 DOI:10.1073/pnas.93.24.14158 PMID:8943077
- Schulteis, G., Koob, G. F. Reinforcement processes in opiate addiction: A homeostatic model Neurochemical Research 1996 21:1437-1454 DOI:10.1007/bf02532385 PMID:8947934
- Parsons, L. H., Weiss, F., Koob, G. F. Serotonin(1B) receptor stimulation enhances dopamine mediated reinforcement Psychopharmacology 1996 128:150-160 DOI:10.1007/s002130050120 PMID:8956376
- Roberts, A. J., Cole, M., Koob, G. F. Intra-amygdala muscimol decreases operant ethanol self-administration in dependent rats Alcoholism-Clinical and Experimental Research 1996 20:1289-1298 DOI:10.1111/j.1530-0277.1996.tb01125.x PMID:8904984
- Solbrig, M. V., Koob, G. F., Fallon, J. H., Reid, S., Lipkin, W. I. Prefrontal cortex dysfunction in borna disease virus (bdv)-infected rats Biological Psychiatry 1996 40:629-636 DOI:10.1016/0006-3223(95)00480-7 PMID:8886296
- Spina, M., MerloPich, E., Chan, R. K. W., Basso, A. M., Rivier, J., Vale, W., Koob, G. F. Appetite-suppressing effects of urocortin, a crf-related neuropeptide Science 1996 273:1561-1564 DOI:10.1126/science.273.5281.1561 PMID:8703220
- Heinrichs, S. C., StenzelPoore, M. P., Gold, L. H., Battenberg, E., Bloom, F. E., Koob, G. F., Vale, W. W., Pich, E. M. Learning impairment in transgenic mice with central overexpression of corticotropin-releasing factor Neuroscience 1996 74:303-311 DOI:10.1016/0306-4522(96)00140-6 PMID:8865183
- Vankova, M. E., Weinger, M. B., Chen, D. Y., Bronson, J. B., Motis, V., Koob, G. F. Role of central mu, delta-1, and kappa-1 opioid receptors in opioid-induced muscle rigidity in the rat Anesthesiology 1996 85:574-583 DOI:10.1097/00000542-199609000-00017 PMID:8853088
- Solbrig, M. V., Koob, G. F., Joyce, J. N., Lipkin, W. I. A neural substrate of hyperactivity in borna disease: Changes in brain dopamine receptors Virology 1996 222:332-338 DOI:10.1006/viro.1996.0430 PMID:8806517
- Weissenborn, R., Deroche, V., Koob, G. F., Weiss, F. Effects of dopamine agonists and antagonists on cocaine induced operant responding for a cocaine-associated stimulus Psychopharmacology 1996 126:311-322 PMID:8878347
- Menzaghi, F., Heinrichs, S. C., VargasCortes, M., Goldstein, G., Koob, G. F. Iri-514, a synthetic peptide analogue of thymopentin, reduces the behavioral response to social stress in rats Physiology & Behavior 1996 60:397-401 DOI:10.1016/0031-9384(96)00034-0 PMID:8840897
- Koob, G. F. Hedonic valence, dopamine and motivation Molecular Psychiatry 1996 1:186-189 PMID:9118342
- delaTorre, J. C., Mallory, M., Brot, M., Gold, L., Koob, G., Oldstone, M. B. A., Masliah, E. Viral persistence in neurons alters synaptic plasticity and cognitive functions without destruction of brain cells Virology 1996 220:508-515 DOI:10.1006/viro.1996.0340 PMID:8661403
- Hyytia, P., Schulteis, G., Koob, G. F. Intravenous heroin and ethanol self administration by alcohol preferring aa and alcohol-avoiding ana rats Psychopharmacology 1996 125:248-254 DOI:10.1007/bf02247335 PMID:8815960
- Matthews, K., Baldo, B. A., Markou, A., Lown, O., Overstreet, D. H., Koob, G. F. Rewarding electrical brain stimulation: Similar thresholds for flinders sensitive line hypercholinergic and flinders resistant line hypocholinergic rats Physiology & Behavior 1996 59:1155-1162 DOI:10.1016/0031-9384(95)02212-0 PMID:8737906
- Weiss, F., Parsons, L. H., Schulteis, G., Hyytia, P., Lorang, M. T., Bloom, F. E., Koob, G. F. Ethanol self-administration restores withdrawal-associated deficiencies in accumbal dopamine and 5-hydroxytryptamine release in dependent rats Journal of Neuroscience 1996 16:3474-3485 PMID:8627380
- Koob, G. F. Drug addiction: The yin and yang of hedonic homeostasis Neuron 1996 16:893-896 DOI:10.1016/s0896-6273(00)80109-9 PMID:8630244
- Korte, S. M., KorteBouws, G. A. H., Koob, G. F., DeKloet, E. R., Bohus, B. Mineralocorticoid and glucocorticoid receptor antagonists in animal models of anxiety Pharmacology, Biochemistry and Behavior 1996 54:261-267 DOI:10.1016/0091-3057(95)02172-8 PMID:8728567
- Solbrig, M. V., Koob, G. F., Lipkin, W. I. Naloxone-induced seizures in rats infected with borna disease virus Neurology 1996 46:1170-1171 PMID:8780117
- Macey, D. J., Schulteis, G., Heinrichs, S. C., Koob, G. F. Time-dependent quantifiable withdrawal from ethanol in the rat: Effect of method of dependence induction Alcohol 1996 13:163-170 DOI:10.1016/0741-8329(95)02030-6 PMID:8814651
- Bono, G., Balducci, C., Richelmi, P., Koob, G. F., Pulvirenti, L. Dopamine partial receptor agonists reduce ethanol intake in the rat European Journal of Pharmacology 1996 296:233-238 DOI:10.1016/0014-2999(95)00592-7 PMID:8904074
- Schulteis, G., Hyytia, P., Heinrichs, S. C., Koob, G. F. Effects of chronic ethanol exposure on oral self-administration of ethanol or saccharin by wistar rats Alcoholism-Clinical and Experimental Research 1996 20:164-171 DOI:10.1111/j.1530-0277.1996.tb01060.x PMID:8651448
- deFonseca, F. R., Rubio, P., Menzaghi, F., MerloPich, E., Rivier, J., Koob, G. F., Navarro, M. Corticotropin-releasing factor (crf) antagonist d-phe(12),nle(21,38),c(alpha)meleu(37) crf attenuates the acute actions of the highly potent cannabinoid receptor agonist hu-210 on defensive-withdrawal behavior in rats Journal of Pharmacology and Experimental Therapeutics 1996 276:56-64 PMID:8558457
- Pulvirenti, L., Balducci, C., Koob, G. F. Inhibition of nitric oxide synthesis reduces intravenous cocaine self-administration in the rat Neuropharmacology 1996 35:1811-1814 DOI:10.1016/s0028-3908(96)00152-9 PMID:9076761
- Parsons, L. H., Caine, S. B., Sokoloff, P., Schwartz, J. C., Koob, G. F., Weiss, F. Neurochemical evidence that postsynaptic nucleus accumbens D3 receptor stimulation enhances cocaine reinforcement Journal of Neurochemistry 1996 67:1078-1089 DOI:10.1046/j.1471-4159.1996.67031078.x PMID:8752115
- Carrera, M. R. A., Ashley, J. A., Parsons, L. H., Wirsching, P., Koob, G. F., Janda, K. D. Suppression of psychoactive effects of cocaine by active immunization Nature 1995 378:727-730 DOI:10.1038/378727a0 PMID:7501020
- Caine, S. B., Heinrichs, S. C., Coffin, V. L., Koob, G. F. Effects of the dopamine d-1 antagonist sch-23390 microinjected into the accumbens, amygdala or striatum on cocaine self-administration in the rat Brain Research 1995 692:47-56 PMID:8548319
- Hyytia, P., Koob, G. F. Gaba(a) receptor antagonism in the extended amygdala decreases ethanol self-administration in rats European Journal of Pharmacology 1995 283:151-159 DOI:10.1016/0014-2999(95)00314-b PMID:7498304
- Parsons, L. H., Koob, G. F., Weiss, F. Serotonin dysfunction in the nucleus accumbens of rats during withdrawal after unlimited access to intravenous cocaine Journal of Pharmacology and Experimental Therapeutics 1995 274:1182-1191 PMID:7562486
- Schulteis, G., Markou, A., Cole, M., Koob, G. F. Decreased brain reward produced by ethanol withdrawal Proceedings of the National Academy of Sciences of the United States of America 1995 92:5880-5884 DOI:10.1073/pnas.92.13.5880 PMID:7597046
- Weissenborn, R., Yackey, M., Koob, G. F., Weiss, F. Measures of cocaine-seeking behavior using a multiple schedule of food and drug self-administration in rats Drug and Alcohol Dependence 1995 38:237-246 DOI:10.1016/0376-8716(95)01107-a PMID:7555624
- Caine, S. B., Koob, G. F. Pretreatment with the dopamine agonist 7-oh-dpat shifts the cocaine self-administration dose-effect function to the left under different schedules in the rat Behavioural Pharmacology 1995 6:333-347 PMID:11224342
- Richter, R. M., Pich, E. M., Koob, G. F., Weiss, F. Sensitization of cocaine-stimulated increase in extracellular levels of corticotropin-releasing factor from the rat amygdala after repeated administration as determined by intracranial microdialysis Neuroscience Letters 1995 187:169-172 DOI:10.1016/0304-3940(95)11365-4 PMID:7624019
- Defonseca, F. R., Rubio, P., Martincalderon, J. L., Caine, S. B., Koob, G. F., Navarro, M. The dopamine-receptor agonist 7-oh-dpat modulates the acquisition and expression of morphine-induced place preference European Journal of Pharmacology 1995 274:47-55 DOI:10.1016/0014-2999(94)00708-f PMID:7768280
- Withers, N. W., Pulvirenti, L., Koob, G. F., Gillin, J. C. Cocaine abuse and dependence Journal of Clinical Psychopharmacology 1995 15:63-78 DOI:10.1097/00004714-199502000-00010 PMID:7714230
- Raber, J., Koob, G. F., Bloom, F. E. Interleukin-2 (il-2) induces corticotropin-releasing factor (crf) release from the amygdala and involves a nitric oxide-mediated signaling - comparison with the hypothalamic response Journal of Pharmacology and Experimental Therapeutics 1995 272:815-824 PMID:7853199
- Weinger, M. B., Chen, D. Y., Lin, T., Lau, C., Koob, G. F., Smith, N. T. A role for cns alpha-2-adrenergic receptors in opiate-induced muscle rigidity in the rat Brain Research 1995 669:10-18 DOI:10.1016/0006-8993(94)01216-5 PMID:7712151
- Heinrichs, S. C., Menzaghi, F., Schulteis, G., Koob, G. F., Stinus, L. Suppression of corticotropin-releasing factor in the amygdala attenuates aversive consequences of morphine-withdrawal Behavioural Pharmacology 1995 6:74-80 PMID:11224314
- Mitler, M. M., Aldrich, M. S., Koob, G. F., Zarcone, V. P. Narcolepsy and its treatment with stimulants Sleep 1994 17:352-371 PMID:7973321
- Schulteis, G., Markou, A., Gold, L. H., Stinus, L., Koob, G. F. Relative sensitivity to naloxone of multiple indexes of opiate withdrawal - a quantitative dose-response analysis Journal of Pharmacology and Experimental Therapeutics 1994 271:1391-1398 PMID:7996451
- Pulvirenti, L., Berrier, R., Kreifeldt, M., Koob, G. F. Modulation of locomotor-activity by nmda receptors in the nucleus-accumbens core and shell regions of the rat Brain Research 1994 664:231-236 DOI:10.1016/0006-8993(94)91977-1 PMID:7895034
- Xu, M., Moratalla, R., Gold, L. H., Hiroi, N., Koob, G. F., Graybiel, A. M., Tonegawa, S. Dopamine d1 receptor mutant mice are deficient in striatal expression of dynorphin and in dopamine-mediated behavioral-responses Cell 1994 79:729-742 DOI:10.1016/0092-8674(94)90557-6 PMID:7954836
- Markou, A., Matthews, K., Overstreet, D. H., Koob, G. F., Geyer, M. A. Flinders resistant hypocholinergic rats exhibit startle sensitization and reduced startle thresholds Biological Psychiatry 1994 36:680-688 DOI:10.1016/0006-3223(94)91177-0 PMID:7880937
- Heinrichs, S. C., Menzaghi, F., Pich, E. M., Baldwin, H. A., Rassnick, S., Britton, K. T., Koob, G. F. Antistress action of a corticotropin-releasing factor antagonist on behavioral reactivity to stressors of varying type and intensity Neuropsychopharmacology 1994 11:179-186 DOI:10.1038/sj.npp.1380104 PMID:786509
- Pulvirenti, L., Koob, G. F. Dopamine-receptor agonists, partial agonists and psychostimulant addiction Trends in Pharmacological Sciences 1994 15:374-379 DOI:10.1016/0165-6147(94)90158-9 PMID:7809953
- Gold, L. H., Brot, M. D., Polis, I., Schroeder, R., Tishon, A., Delatorre, J. C., Oldstone, M. B. A., Koob, G. F. Behavioral-effects of persistent lymphocytic choriomeningitis virus-infection in mice Behavioral and Neural Biology 1994 62:100-109 DOI:10.1016/s0163-1047(05)80031-7 PMID:7993301
- Korte, S. M., Kortebouws, G. A. H., Bohus, B., Koob, G. F. Effect of corticotropin-releasing factor antagonist on behavioral and neuroendocrine responses during exposure to defensive burying paradigm in rats Physiology & Behavior 1994 56:115-120 DOI:10.1016/0031-9384(94)90268-2 PMID:8084889
- Caine, S. B., Koob, G. F. Effects of dopamine d-1 and d-2 antagonists on cocaine self-administration under different schedules of reinforcement in the rat Journal of Pharmacology and Experimental Therapeutics 1994 270:209-218 PMID:8035317
- Gillin, J. C., Pulvirenti, L., Withers, N., Golshan, S., Koob, G. The effects of lisuride on mood and sleep during acute withdrawal in stimulant abusers - a preliminary-report Biological Psychiatry 1994 35:843-849 PMID:8054406
- Menzaghi, F., Howard, R. L., Heinrichs, S. C., Vale, W., Rivier, J., Koob, G. F. Characterization of a novel and potent corticotropin-releasing factor antagonist in rats Journal of Pharmacology and Experimental Therapeutics 1994 269:564-572 PMID:8182523
- Stenzelpoore, M. P., Heinrichs, S. C., Rivest, S., Koob, G. F., Vale, W. W. Overproduction of corticotropin-releasing factor in transgenic mice - a genetic model of anxiogenic behavior Journal of Neuroscience 1994 14:2579-2584 PMID:8182429
- Pulvirenti, L., Koob, G. F. Lisuride reduces intravenous cocaine self-administration in rats Pharmacology, Biochemistry and Behavior 1994 47:819-822 DOI:10.1016/0091-3057(94)90281-x PMID:8029249
- Cole, B. J., Koob, G. F. Corticotropin-releasing factor and schedule-induced-polydipsia Pharmacology, Biochemistry and Behavior 1994 47:393-398 DOI:10.1016/0091-3057(94)90134-1 PMID:8208756
- Caine, S. B., Koob, G. F. Effects of mesolimbic dopamine depletion on responding maintained by cocaine and food Journal of the Experimental Analysis of Behavior 1994 61:213-221 DOI:10.1901/jeab.1994.61-213 PMID:8169570 PMCID:PMC1334409
- Raber, J., Pich, E. M., Koob, G. F., Bloom, F. E. Il-1-beta potentiates the acetylcholine-induced release of vasopressin from the hypothalamus in-vitro, but not from the amygdala Neuroendocrinology 1994 59:208-217 DOI:10.1159/000126661 PMID:8159270
- Menzaghi, F., Heinrichs, S. C., Merlopich, E., Tilders, F. J. H., Koob, G. F. Involvement of hypothalamic corticotropin-releasing factor neurons in behavioral-responses to novelty in rats Neuroscience Letters 1994 168:139-142 DOI:10.1016/0304-3940(94)90435-9 PMID:8028766
- Gold, L. H., Stinus, L., Inturrisi, C. E., Koob, G. F. Prolonged tolerance, dependence and abstinence following subcutaneous morphine pellet implantation in the rat European Journal of Pharmacology 1994 253:45-51 DOI:10.1016/0014-2999(94)90755-2 PMID:8013548
- Heilig, M., Koob, G. F., Ekman, R., Britton, K. T. Corticotropin-releasing factor and neuropeptide-y - role in emotional integration Trends in Neurosciences 1994 17:80-85 DOI:10.1016/0166-2236(94)90079-5 PMID:7512773
- Koob, G. F., Caine, B., Markou, A., Pulvirenti, L., Weiss, F. Role for the mesocortical dopamine system in the motivating effects of cocaine NIDA Research Monograph 1994 145:1-18 PMID:8742805
- Pulvirenti, L., Smith, D., Koob, G. F. Sdz 208-911, an amino-ergoline with partial dopamine agonist properties, dose-dependently increases cocaine self-administration in the rat Psychopharmacology 1994 113:518-520 DOI:10.1007/bf02245232 PMID:7862868
- Weiss, F., Lorang, M. T., Bloom, F. E., Koob, G. F. Oral alcohol self-administration stimulates dopamine release in the rat nucleus-accumbens - genetic and motivational determinants Journal of Pharmacology and Experimental Therapeutics 1993 267:250-258 PMID:8229752
- Rassnick, S., Stinus, L., Koob, G. F. The effects of 6-hydroxydopamine lesions of the nucleus-accumbens and the mesolimbic dopamine system on oral self-administration of ethanol in the rat Brain Research 1993 623:16-24 DOI:10.1016/0006-8993(93)90004-7 PMID:8221085
- Robledo, P., Maldonado, R., Koob, G. F. Neurotensin injected into the nucleus-accumbens blocks the psychostimulant effects of cocaine but does not attenuate cocaine self-administration in the rat Brain Research 1993 622:105-112 DOI:10.1016/0006-8993(93)90808-z PMID:8242350
- Markou, A., Weiss, F., Gold, L. H., Caine, S. B., Schulteis, G., Koob, G. F. Animal-models of drug craving Psychopharmacology 1993 112:163-182 DOI:10.1007/bf02244907 PMID:7871016
- Pich, E. M., Koob, G. F., Heilig, M., Menzaghi, F., Vale, W., Weiss, F. Corticotropin-releasing factor release from the mediobasal hypothalamus of the rat as measured by microdialysis Neuroscience 1993 55:695-707 DOI:10.1016/0306-4522(93)90435-i PMID:8413932
- Koob, G. F., Cador, M. Psychomotor stimulant sensitization - the corticotropin-releasing factor steroid connection - commentary on psychomotor-stimulant sensitization - a unitary phenomenon Behavioural Pharmacology 1993 4:351-354 PMID:11224203
- Menzaghi, F., Heinrichs, S. C., Pich, E. M., Tilders, F. J. H., Koob, G. F. Functional impairment of hypothalamic corticotropin-releasing factor neurons with immunotargeted toxins enhances food-intake induced by neuropeptide-y Brain Research 1993 618:76-82 DOI:10.1016/0006-8993(93)90431-l PMID:8402180
- Swerdlow, N. R., Koob, G. F., Cador, M., Lorang, M., Hauger, R. L. Pituitary-adrenal axis responses to acute amphetamine in the rat Pharmacology, Biochemistry and Behavior 1993 45:629-637 DOI:10.1016/0091-3057(93)90518-x PMID:8392732
- Robledo, P., Koob, G. F. Two discrete nucleus accumbens projection areas differentially mediate cocaine self-administration in the rat Behavioural Brain Research 1993 55:159-166 DOI:10.1016/0166-4328(93)90112-4 PMID:8395179
- Caine, S. B., Koob, G. F. Modulation of cocaine self-administration in the rat through d-3 dopamine-receptors Science 1993 260:1814-1816 DOI:10.1126/science.8099761 PMID:8099761
- Heilig, M., McLeod, S., Brot, M., Heinrichs, S. C., Menzaghi, F., Koob, G. F., Britton, K. T. Anxiolytic-like action of neuropeptide-y - mediation by y1 receptors in amygdala, and dissociation from food-intake effects Neuropsychopharmacology 1993 8:357-363 PMID:809979
- Negus, S. S., Henriksen, S. J., Mattox, A., Pasternak, G. W., Portoghese, P. S., Takemori, A. E., Weinger, M. B., Koob, G. F. Effect of antagonists selective for mu-opioid, delta-opioid and kappa-opioid receptors on the reinforcing effects of heroin in rats Journal of Pharmacology and Experimental Therapeutics 1993 265:1245-1252 PMID:8389859
- Heinrichs, S. C., Menzaghi, F., Pich, E. M., Hauger, R. L., Koob, G. F. Corticotropin-releasing factor in the paraventricular nucleus modulates feeding induced by neuropeptide-y Brain Research 1993 611:18-24 DOI:10.1016/0006-8993(93)91771-j PMID:8518948
- Maldonado, R., Robledo, P., Chover, A. J., Caine, S. B., Koob, G. F. D(1) dopamine-receptors in the nucleus-accumbens modulate cocaine self-administration in the rat Pharmacology, Biochemistry and Behavior 1993 45:239-242 DOI:10.1016/0091-3057(93)90112-7 PMID:8516365
- Pulvirenti, L., Koob, G. F. Lisuride reduces psychomotor retardation during withdrawal from chronic intravenous amphetamine self-administration in rats Neuropsychopharmacology 1993 8:213-218 PMID:850734
- Amalric, M., Berhow, M., Polis, I., Koob, G. F. Selective effects of low-dose d2-dopamine receptor antagonism in a reaction-time-task in rats Neuropsychopharmacology 1993 8:195-200 PMID:850734
- Hammer, R. P., Pires, W. S., Markou, A., Koob, G. F. Withdrawal following cocaine self-administration decreases regional cerebral metabolic-rate in critical brain reward regions Synapse 1993 14:73-80 DOI:10.1002/syn.890140110 PMID:8511720
- Rassnick, S., Krechman, J., Koob, G. F. Chronic ethanol produces a decreased sensitivity to the response-disruptive effects of gaba receptor complex antagonists Pharmacology, Biochemistry and Behavior 1993 44:943-950 DOI:10.1016/0091-3057(93)90029-s PMID:8385785
- Cador, M., Cole, B. J., Koob, G. F., Stinus, L., Lemoal, M. Central administration of corticotropin releasing-factor induces long-term sensitization to d-amphetamine Brain Research 1993 606:181-186 DOI:10.1016/0006-8993(93)90982-s PMID:8490714
- Maldonado, R., Koob, G. F. Destruction of the locus-ceruleus decreases physical signs of opiate withdrawal Brain Research 1993 605:128-138 DOI:10.1016/0006-8993(93)91364-x PMID:8467382
- Rassnick, S., Heinrichs, S. C., Britton, K. T., Koob, G. F. Microinjection of a corticotropin-releasing factor antagonist into the central nucleus of the amygdala reverses anxiogenic-like effects of ethanol withdrawal Brain Research 1993 605:25-32 DOI:10.1016/0006-8993(93)91352-s PMID:8467387
- Rassnick, S., Pulvirenti, L., Koob, G. F. Sdz-205,152, a novel dopamine receptor agonist, reduces oral ethanol self-administration in rats Alcohol 1993 10:127-132 DOI:10.1016/0741-8329(93)90091-2 PMID:8095143
- Negus, S. S., Pasternak, G. W., Koob, G. F., Weinger, M. B. Antagonist effects of beta-funaltrexamine and naloxonazine on alfentanil-induced antinociception and muscle rigidity in the rat Journal of Pharmacology and Experimental Therapeutics 1993 264:739-745 PMID:8437122
- Rassnick, S., Damico, E., Riley, E., Koob, G. F. Gaba antagonist and benzodiazepine partial inverse agonist reduce motivated responding for ethanol Alcoholism-Clinical and Experimental Research 1993 17:124-130 DOI:10.1111/j.1530-0277.1993.tb00736.x PMID:8383923
- Wahlestedt, C., Pich, E. M., Koob, G. F., Yee, F., Heilig, M. Modulation of anxiety and neuropeptide-y-y1 receptors by antisense oligodeoxynucleotides Science 1993 259:528-531 DOI:10.1126/science.8380941 PMID:8380941
- Pich, E. M., Heinrichs, S. C., Rivier, C., Miczek, K. A., Fisher, D. A., Koob, G. F. Blockade of pituitary-adrenal axis activation-induced by peripheral immunoneutralization of corticotropin-releasing factor does not affect the behavioral-response to social defeat stress in rats Psychoneuroendocrinology 1993 18:495-507 PMID:82657
- Koob, G. F., Markou, A., Weiss, F., Schulteis, G. Opponent process and drug dependence: neurobiological mechanisms Seminars in Neuroscience 1993 5:351-358 DOI:10.1016/S1044-5765(05)80043-0
- Baldwin, H. A., Koob, G. F. Rapid induction of conditioned opiate withdrawal in the rat Neuropsychopharmacology 1993 8:15-21 PMID:8424845
- Koob, G. F., Heinrichs, S. C., Pich, E. M., Menzaghi, F., Baldwin, H., Miczek, K., Britton, K. T. The role of corticotropin-releasing factor in behavioral-responses to stress Ciba Foundation Symposia 1993 172:277-295 PMID:8491090
- Cador, M., Ahmed, S. H., Koob, G. F., Lemoal, M., Stinus, L. Corticotropin-releasing factor induces a place aversion independent of its neuroendocrine role Brain Research 1992 597:304-309 DOI:10.1016/0006-8993(92)91487-y PMID:1473001
- Maldonado, R., Negus, S., Koob, G. F. Precipitation of morphine-withdrawal syndrome in rats by administration of mu-selective, delta-selective and kappa-selective opioid antagonists Neuropharmacology 1992 31:1231-1241 DOI:10.1016/0028-3908(92)90051-p PMID:1335131
- Markou, A., Koob, G. F. Bromocriptine reverses the elevation in intracranial self-stimulation thresholds observed in a rat model of cocaine withdrawal Neuropsychopharmacology 1992 7:213-224 PMID:138864
- Markou, A., Hauger, R. L., Koob, G. F. Desmethylimipramine attenuates cocaine withdrawal in rats Psychopharmacology 1992 109:305-314 DOI:10.1007/bf02245878 PMID:1365631
- Weiss, F., Paulus, M. P., Lorang, M. T., Koob, G. F. Increases in extracellular dopamine in the nucleus-accumbens by cocaine are inversely related to basal levels - effects of acute and repeated administration Journal of Neuroscience 1992 12:4372-4380 PMID:1432099
- Pulvirenti, L., Maldonadolopez, R., Koob, G. F. Nmda receptors in the nucleus-accumbens modulate intravenous cocaine but not heroin self-administration in the rat Brain Research 1992 594:327-330 DOI:10.1016/0006-8993(92)91145-5 PMID:1360323
- Weiss, F., Markou, A., Lorang, M. T., Koob, G. F. Basal extracellular dopamine levels in the nucleus-accumbens are decreased during cocaine withdrawal after unlimited-access self-administration Brain Research 1992 593:314-318 DOI:10.1016/0006-8993(92)91327-b PMID:1450939
- Heinrichs, S. C., Koob, G. F. Corticotropin-releasing factor modulates dietary preference in nutritionally and physically stressed rats Psychopharmacology 1992 109:177-184 DOI:10.1007/bf02245497 PMID:1365653
- Rassnick, S., Pulvirenti, L., Koob, G. F. Oral ethanol self-administration in rats is reduced by the administration of dopamine and glutamate receptor antagonists into the nucleus-accumbens Psychopharmacology 1992 109:92-98 DOI:10.1007/bf02245485 PMID:1365677
- Heinrichs, S. C., Cole, B. J., Pich, E. M., Menzaghi, F., Koob, G. F., Hauger, R. L. Endogenous corticotropin-releasing factor modulates feeding induced by neuropeptide-y or a tail-pinch stressor Peptides 1992 13:879-884 DOI:10.1016/0196-9781(92)90044-4 PMID:1480513
- Cador, M., Dumas, S., Cole, B. J., Mallet, J., Koob, G. F., Lemoal, M., Stinus, L. Behavioral sensitization induced by psychostimulants or stress - search for a molecular-basis and evidence for a crf-dependent phenomenon Annals of the New York Academy of Sciences 1992 654:416-420 DOI:10.1111/j.1749-6632.1992.tb25985.x PMID:1352953
- Rassnick, S., Damico, E., Riley, E., Pulvirenti, L., Zieglgansberger, W., Koob, G. F. Gaba and nucleus-accumbens glutamate neurotransmission modulate ethanol self-administration in rats Annals of the New York Academy of Sciences 1992 654:502-505 PMID:1352956
- Koob, G. F. Neural mechanisms of drug reinforcement Annals of the New York Academy of Sciences 1992 654:171-191 DOI:10.1111/j.1749-6632.1992.tb25966.x PMID:1632582
- Weiss, F., Hurd, Y. L., Ungerstedt, U., Markou, A., Plotsky, P. M., Koob, G. F. Neurochemical correlates of cocaine and ethanol self-administration Annals of the New York Academy of Sciences 1992 654:220-241 DOI:10.1111/j.1749-6632.1992.tb25970.x PMID:1632585
- Robledo, P., Maldonadolopez, R., Koob, G. F. Role of dopamine-receptors in the nucleus-accumbens in the rewarding properties of cocaine Annals of the New York Academy of Sciences 1992 654:509-512 DOI:10.1111/j.1749-6632.1992.tb26015.x PMID:1385935
- Heinrichs, S. C., Pich, E. M., Miczek, K. A., Britton, K. T., Koob, G. F. Corticotropin-releasing factor antagonist reduces emotionality in socially defeated rats via direct neurotropic action Brain Research 1992 581:190-197 DOI:10.1016/0006-8993(92)90708-h PMID:1327398
- Koob, G. F. Drugs of abuse - anatomy, pharmacology and function of reward pathways Trends in Pharmacological Sciences 1992 13:177-184 DOI:10.1016/0165-6147(92)90060-j PMID:1604710
- Koob, G. F., Maldonado, R., Stinus, L. Neural substrates of opiate withdrawal Trends in Neurosciences 1992 15:186-191 DOI:10.1016/0166-2236(92)90171-4 PMID:1377426
- Maldonado, R., Stinus, L., Gold, L. H., Koob, G. F. Role of different brain structures in the expression of the physical morphine-withdrawal syndrome Journal of Pharmacology and Experimental Therapeutics 1992 261:669-677 PMID:1578378
- Weinberger, S. B., Koob, G. F., Martinez, J. L. Differences in one-way active-avoidance learning in mice of 3 inbred strains Behavior Genetics 1992 22:177-188 DOI:10.1007/bf01066996 PMID:1596257
- Rassnick, S., Koob, G. F., Geyer, M. A. Responding to acoustic startle during chronic ethanol intoxication and withdrawal Psychopharmacology 1992 106:351-358 DOI:10.1007/bf02245417 PMID:1570382
- Britton, K. T., McLeod, S., Koob, G. F., Hauger, R. Pregnane steroid alphaxalone attenuates anxiogenic behavioral-effects of corticotropin releasing-factor and stress Pharmacology, Biochemistry and Behavior 1992 41:399-403 DOI:10.1016/0091-3057(92)90117-x PMID:1315440
- Markou, A., Koob, G. F. Construct-validity of a self-stimulation threshold paradigm - effects of reward and performance manipulations Physiology & Behavior 1992 51:111-119 DOI:10.1016/0031-9384(92)90211-j PMID:1741436
- Heinrichs, S. C., Britton, K. T., Koob, G. F. Both conditioned taste preference and aversion induced by corticotropin-releasing factor Pharmacology, Biochemistry and Behavior 1991 40:717-721 DOI:10.1016/0091-3057(91)90075-d PMID:1667823
- Bluthe, R. M., Koob, G. F., Dantzer, R. Hypertonic saline mimics the effects of vasopressin and social recognition in rats Behavioural Pharmacology 1991 2:513-516 PMID:11224093
- Pulvirenti, L., Swerdlow, N. R., Koob, G. F. Nucleus-accumbens nmda antagonist decreases locomotor-activity produced by cocaine, heroin or accumbens dopamine, but not caffeine Pharmacology, Biochemistry and Behavior 1991 40:841-845 DOI:10.1016/0091-3057(91)90095-j PMID:1687766
- Baldwin, H. A., Wall, T. L., Schuckit, M. A., Koob, G. F. Differential-effects of ethanol on punished responding in the p-rats and np-rats Alcoholism-Clinical and Experimental Research 1991 15:700-704 DOI:10.1111/j.1530-0277.1991.tb00582.x PMID:1928646
- Swerdlow, N. R., Hauger, R., Irwin, M., Koob, G. F., Britton, K. T., Pulvirenti, L. Endocrine, immune, and neurochemical changes in rats during withdrawal from chronic amphetamine intoxication Neuropsychopharmacology 1991 5:23-31 PMID:1657016
- Britton, K. T., Page, M., Baldwin, H., Koob, G. F. Anxiolytic activity of steroid anesthetic alphaxalone Journal of Pharmacology and Experimental Therapeutics 1991 258:124-129 PMID:1677035
- Weinger, M. B., Smith, N. T., Blasco, T. A., Koob, G. F. Brain sites mediating opiate-induced muscle rigidity in the rat - methylnaloxonium mapping study Brain Research 1991 544:181-190 DOI:10.1016/0006-8993(91)90052-w PMID:2039935
- Schroeder, R. L., Weinger, M. B., Vakassian, L., Koob, G. F. Methylnaloxonium diffuses out of the rat-brain more slowly than naloxone after direct intracerebral injection Neuroscience Letters 1991 121:173-177 DOI:10.1016/0304-3940(91)90678-m PMID:2020373
- Baldwin, H. A., Rassnick, S., Rivier, J., Koob, G. F., Britton, K. T. Crf antagonist reverses the anxiogenic response to ethanol withdrawal in the rat Psychopharmacology 1991 103:227-232 DOI:10.1007/bf02244208 PMID:2027923
- Markou, A., Koob, G. F. Postcocaine anhedonia: an animal model of cocaine withdrawal Neuropsychopharmacology 1991 4:17-26 PMID:2003866
- Ehlers, C. L., Chaplin, R. I., Koob, G. F. EEG effects of RO-15-4513 and FG-7142 alone and in combination with ethanol Pharmacology, Biochemistry and Behavior 1990 36:607-611 DOI:10.1016/0091-3057(90)90263-h PMID:2165619
- Koob, G. F., Weiss, F. Pharmacology of drug self-administration Alcohol 1990 7:193-197 DOI:10.1016/0741-8329(90)90004-v PMID:1970479
- Cole, B. J., Cador, M., Stinus, L., Rivier, J., Vale, W., Koob, G. F., Lemoal, M. Central administration of a crf antagonist blocks the development of stress-induced behavioral sensitization Brain Research 1990 512:343-346 DOI:10.1016/0006-8993(90)90646-s PMID:2354366
- Hubner, C. B., Koob, G. F. Bromocriptine produces decreases in cocaine self-administration in the rat Neuropsychopharmacology 1990 3:101-108 PMID:231726
- Weinger, M. B., Schreiber, J. F., Koob, G. F. Effects of 2 benzodiazepine inverse agonists, ro-15-4513 and fg-7142, on recovery from pentobarbital and halothane anesthesia in the rat Pharmacology, Biochemistry and Behavior 1990 35:889-895 DOI:10.1016/0091-3057(90)90376-s PMID:2111915
- Swerdlow, N. R., Koob, G. F. Toward a unified hypothesis of cortico-striato-pallido-thalamus function? Behavioral and Brain Sciences 1990 13:172-177 DOI:10.1017/S0140525X00078195
- Hurd, Y. L., Weiss, F., Koob, G., Ungerstedt, U. The influence of cocaine self-administration on in vivo dopamine and acetylcholine neurotransmission in rat caudate-putamen Neuroscience Letters 1990 109:227-233 DOI:10.1016/0304-3940(90)90568-t PMID:2314639
- Hubner, C. B., Koob, G. F. The ventral pallidum plays a role in mediating cocaine and heroin self-administration in the rat Brain Research 1990 508:20-29 DOI:10.1016/0006-8993(90)91112-t PMID:2337788
- Swerdlow, N. R., Mansbach, R. S., Geyer, M. A., Pulvirenti, L., Koob, G. F., Braff, D. L. Amphetamine disruption of prepulse inhibition of acoustic startle is reversed by depletion of mesolimbic dopamine Psychopharmacology 1990 100:413-416 DOI:10.1007/bf02244616 PMID:2315438
- Cole, B. J., Cador, M., Stinus, L., Rivier, C., Rivier, J., Vale, W., Lemoal, M., Koob, G. F. Critical role of the hypothalamic pituitary-adrenal axis in amphetamine-induced sensitization of behavior Life Sciences 1990 47:1715-1720 DOI:10.1016/0024-3205(90)90344-q PMID:2250584
- Melia, K. F., Koob, G. F., Ehlers, C. L. Ethanol effects on delayed spatial matching as modeled by a negative exponential forgetting function Psychopharmacology 1990 102:391-398 DOI:10.1007/bf02244109 PMID:2251335
- Weiss, F., Mitchiner, M., Bloom, F. E., Koob, G. F. Free-choice responding for ethanol versus water in alcohol preferring (p) and unselected wistar rats is differentially modified by naloxone, bromocriptine, and methysergide Psychopharmacology 1990 101:178-186 DOI:10.1007/bf02244123 PMID:2349359
- Stinus, L., Lemoal, M., Koob, G. F. Nucleus-accumbens and amygdala are possible substrates for the aversive stimulus effects of opiate withdrawal Neuroscience 1990 37:767-773 DOI:10.1016/0306-4522(90)90106-e PMID:2247222
- Unterwald, E. M., Tempel, A., Koob, G. F., Zukin, R. S. Characterization of opioid receptors in rat nucleus accumbens following mesolimbic dopaminergic lesions Brain Research 1989 505:111-118 DOI:10.1016/0006-8993(89)90120-0 PMID:2558779
- Swerdlow, N. R., Britton, K. T., Koob, G. F. Potentiation of acoustic startle by corticotropin-releasing factor (crf) and by fear are both reversed by alpha-helical crf (9-41) Neuropsychopharmacology 1989 2:285-292 DOI:10.1016/0893-133x(89)90033-x PMID:261082
- Koob, G. F., Lebrun, C., Bluthe, R. M., Dantzer, R., Lemoal, M. Role of neuropeptides in learning versus performance - focus on vasopressin Brain Research Bulletin 1989 23:359-364 DOI:10.1016/0361-9230(89)90222-0 PMID:2686806
- Hurd, Y. L., Weiss, F., Koob, G. F., And, N. E., Ungerstedt, U. Cocaine reinforcement and extracellular dopamine overflow in rat nucleus accumbens: an in vivo microdialysis study Brain Research 1989 498:199-203 DOI:10.1016/0006-8993(89)90422-8 PMID:2790475
- Pulvirenti, L., Swerdlow, N. R., Koob, G. F. Microinjection of a glutamate antagonist into the nucleus accumbens reduces psychostimulant locomotion in rats Neuroscience Letters 1989 103:213-218 DOI:10.1016/0304-3940(89)90578-8 PMID:2771183
- Swerdlow, N. R., Koob, G. F. Norepinephrine stimulates behavioral activation in rats following depletion of nucleus accumbens dopamine Pharmacology, Biochemistry and Behavior 1989 33:595-599 DOI:10.1016/0091-3057(89)90394-8 PMID:2511575
- Amalric, M., Koob, G. F. Dorsal pallidum as a functional motor output of the corpus striatum Brain Research 1989 483:389-394 DOI:10.1016/0006-8993(89)90186-8 PMID:2706530
- Britton, K. T., Koob, G. F. Effects of corticotropin releasing-factor, desipramine and haloperidol on a drl schedule of reinforcement Pharmacology, Biochemistry and Behavior 1989 32:967-970 DOI:10.1016/0091-3057(89)90067-1 PMID:2798545
- Gold, L. H., Hubner, C. B., Koob, G. F. A role for the mesolimbic dopamine system in the psychostimulant actions of mdma Psychopharmacology 1989 99:40-47 DOI:10.1007/bf00634450 PMID:2571175
- Weiss, F., Ettenberg, A., Koob, G. F. Cck-8 injected into the nucleus accumbens attenuates the supersensitive locomotor response to apomorphine in 6-ohda and chronic-neuroleptic treated rats Psychopharmacology 1989 99:409-415 DOI:10.1007/bf00445568 PMID:2574480
- Cole, B. J., Koob, G. F. Low-doses of corticotropin-releasing factor potentiate amphetamine-induced stereotyped behavior Psychopharmacology 1989 99:27-33 DOI:10.1007/bf00634448 PMID:2506602
- Gold, L. H., Koob, G. F. Mdma produces stimulant-like conditioned locomotor-activity Psychopharmacology 1989 99:352-356 DOI:10.1007/bf00445556 PMID:2574478
- Koob, G. F., Wall, T. L., Bloom, F. E. Nucleus accumbens as a substrate for the aversive stimulus effects of opiate withdrawal Psychopharmacology 1989 98:530-534 DOI:10.1007/bf00441954 PMID:2505294
- Koob, G. F., Stinus, L., Lemoal, M., Bloom, F. E. Opponent process theory of motivation - neurobiological evidence from studies of opiate dependence Neuroscience and Biobehavioral Reviews 1989 13:135-140 DOI:10.1016/s0149-7634(89)80022-3 PMID:2682399
- Hand, T. H., Koob, G. F., Stinus, L., Lemoal, M. Aversive properties of opiate receptor blockade - evidence for exclusively central mediation in naive and morphine-dependent rats Brain Research 1988 474:364-368 DOI:10.1016/0006-8993(88)90452-0 PMID:2463060
- Cole, B. J., Koob, G. F. Propranolol antagonizes the enhanced conditioned fear produced by corticotropin releasing-factor Journal of Pharmacology and Experimental Therapeutics 1988 247:902-910 PMID:2849675
- Koob, G. F., Bloom, F. E. Cellular and molecular mechanisms of drug-dependence Science 1988 242:715-723 DOI:10.1126/science.2903550 PMID:2903550
- Koob, G. F., Mendelson, W. B., Schafer, J., Wall, T. L., Britton, K. T., Bloom, F. E. Picrotoxinin receptor ligand blocks anti-punishment effects of alcohol Alcohol 1988 5:437-443 DOI:10.1016/0741-8329(88)90079-1 PMID:2854473
- Gold, L. H., Koob, G. F., Geyer, M. A. Stimulant and hallucinogenic behavioral profiles of 3,4-methylenedioxymethamphetamine and n-ethyl-3,4-methylenedioxyamphetamine in rats Journal of Pharmacology and Experimental Therapeutics 1988 247:547-555 PMID:2903234
- Koob, G. F., Percy, L., Britton, K. T. The effects of ro-15-4513 on the behavioral actions of ethanol in an operant reaction-time task and a conflict test Pharmacology, Biochemistry and Behavior 1988 31:757-760 DOI:10.1016/0091-3057(88)90261-4 PMID:3251257
- Koob, G. F., Swerdlow, N. R. The functional output of the mesolimbic dopamine system Annals of the New York Academy of Sciences 1988 537:216-227 DOI:10.1111/j.1749-6632.1988.tb42108.x PMID:3059925
- Dantzer, R., Koob, G. F., Bluthe, R. M., Lemoal, M. Septal vasopressin modulates social memory in male-rats Brain Research 1988 457:143-147 DOI:10.1016/0006-8993(88)90066-2 PMID:3167559
- Gold, L. H., Swerdlow, N. R., Koob, G. F. The role of mesolimbic dopamine in conditioned locomotion produced by amphetamine Behavioral Neuroscience 1988 102:544-552 DOI:10.1037//0735-7044.102.4.544 PMID:3139012
- Weinger, M. B., Cline, E. J., Smith, N. T., Blasco, T. A., Koob, G. F. Localization of brain-stem sites which mediate alfentanil-induced muscle rigidity in the rat Pharmacology, Biochemistry and Behavior 1988 29:573-580 DOI:10.1016/0091-3057(88)90022-6 PMID:3129743
- Gold, L. H., Koob, G. F. Methysergide potentiates the hyperactivity produced by mdma in rats Pharmacology, Biochemistry and Behavior 1988 29:645-648 DOI:10.1016/0091-3057(88)90034-2 PMID:2896363
- Britton, K. T., Ehlers, C. L., Koob, G. F. Is ethanol antagonist Ro15-4513 selective for ethanol Science 1988 239:648-649 DOI:10.1126/science.3340849 PMID:3340849
- Britton, K. T., Lee, G., Koob, G. F. Corticotropin releasing-factor and amphetamine exaggerate partial agonist properties of benzodiazepine antagonist ro 15-1788 in the conflict test Psychopharmacology 1988 94:306-311 PMID:3128805
- Dantzer, R., Terlouw, C., Tazi, A., Koolhaas, J. M., Bohus, B., Koob, G. F., Lemoal, M. The propensity for schedule-induced-polydipsia is related to differences in conditioned avoidance-behavior and in defense reactions in a defeat test Physiology & Behavior 1988 43:269-273 DOI:10.1016/0031-9384(88)90186-2 PMID:3174839
- Koob, G. F., Wall, T. L., Schafer, J. Rapid induction of tolerance to the antipunishment effects of ethanol Alcohol 1987 4:481-484 DOI:10.1016/0741-8329(87)90090-5 PMID:3435637
- Weinger, M. B., Cline, E. J., Smith, N. T., Koob, G. F. Ketanserin pretreatment reverses alfentanil-induced muscle rigidity Anesthesiology 1987 67:348-354 DOI:10.1097/00000542-198709000-00012 PMID:3115150
- Koob, G. F., Le, H. T., Creese, I. The d1 dopamine receptor antagonist sch-23390 increases cocaine self-administration in the rat Neuroscience Letters 1987 79:315-320 DOI:10.1016/0304-3940(87)90451-4 PMID:2958724
- Tazi, A., Swerdlow, N. R., Lemoal, M., Rivier, J., Vale, W., Koob, G. F. Behavioral activation by crf - evidence for the involvement of the ventral forebrain Life Sciences 1987 41:41-49 DOI:10.1016/0024-3205(87)90554-6 PMID:3496511
- Tazi, A., Dantzer, R., Lemoal, M., Rivier, J., Vale, W., Koob, G. F. Corticotropin-releasing factor antagonist blocks stress-induced fighting in rats Regulatory Peptides 1987 18:37-42 DOI:10.1016/0167-0115(87)90048-6 PMID:3498188
- Amalric, M., Koob, G. F. Depletion of dopamine in the caudate-nucleus but not in nucleus-accumbens impairs reaction-time performance in rats Journal of Neuroscience 1987 7:2129-2134 PMID:3112323
- Lemoal, M., Dantzer, R., Michaud, B., Koob, G. F. Centrally injected arginine vasopressin (avp) facilitates social memory in rats Neuroscience Letters 1987 77:353-359 DOI:10.1016/0304-3940(87)90527-1 PMID:3614767
- Swerdlow, N. R., Koob, G. F. Lesions of the dorsomedial nucleus of the thalamus, medial prefrontal cortex and pedunculopontine nucleus - effects on locomotor-activity mediated by nucleus accumbens-ventral pallidal circuitry Brain Research 1987 412:233-243 DOI:10.1016/0006-8993(87)91129-2 PMID:3607466
- Ehlers, C. L., Chaplin, R. I., Koob, G. F. Antidepressants modulate the CNS effects of corticotropin releasing-factor in rats Medical Science Research-Biochemistry 1987 15:719-720
- Swerdlow, N. R., Koob, G. F. Dopamine, schizophrenia, mania and depression - toward a unified hypothesis of cortico-striato-pallido-thalamic function Behavioral and Brain Sciences 1987 10:197-207
- Swerdlow, N. R., Koob, G. F. Toward a unified neuropsychiatric hypothesis. Response Behavioral and Brain Sciences 1987 10:226-236
- Swerdlow, N. R., Amalric, M., Koob, G. F. Nucleus-accumbens opiate-dopamine interactions and locomotor activation in the rat - evidence for a presynaptic locus Pharmacology, Biochemistry and Behavior 1987 26:765-769 DOI:10.1016/0091-3057(87)90609-5 PMID:3110795
- Lebrun, C., Lemoal, M., Dantzer, R., Bloom, F. E., Koob, G. F. Hypertonic saline mimics the effects of vasopressin on inhibitory avoidance in the rat Behavioral and Neural Biology 1987 47:130-137 DOI:10.1016/s0163-1047(87)90229-9 PMID:3579833
- Dantzer, R., Bluthe, R. M., Koob, G. F., Lemoal, M. Modulation of social memory in male-rats by neurohypophyseal peptides Psychopharmacology 1987 91:363-368 DOI:10.1007/bf00518192 PMID:3104959
- Thatcherbritton, K., Koob, G. F. Alcohol reverses the proconflict effect of corticotropin-releasing factor Regulatory Peptides 1986 16:315-320 DOI:10.1016/0167-0115(86)90031-5 PMID:3031744
- Amalric, M., Koob, G. F., Creese, I., Swerdlow, N. R. Selective d-1 and d-2 receptor antagonists fail to differentially alter supersensitive locomotor behavior in the rat Life Sciences 1986 39:1985-1993 DOI:10.1016/0024-3205(86)90322-x PMID:2946915
- Amalric, M., Blasco, T. A., Smith, N. T., Lee, D. E., Swerdlow, N. R., Koob, G. F. Catatonia produced by alfentanil is reversed by methylnaloxonium microinjections into the brain Brain Research 1986 386:287-295 DOI:10.1016/0006-8993(86)90165-4 PMID:3022882
- Blasco, T. A., Lee, D., Amalric, M., Swerdlow, N. R., Smith, N. T., Koob, G. F. The role of the nucleus raphe pontis and the caudate-nucleus in alfentanil rigidity in the rat Brain Research 1986 386:280-286 DOI:10.1016/0006-8993(86)90164-2 PMID:3096494
- Britton, K. T., Lee, G., Dana, R., Risch, S. C., Koob, G. F. Activating and anxiogenic effects of corticotropin releasing-factor are not inhibited by blockade of the pituitary-adrenal system with dexamethasone Life Sciences 1986 39:1281-1286 DOI:10.1016/0024-3205(86)90189-x PMID:3489874
- Downs, N. S., Britton, K. T., Gibbs, D. M., Koob, G. F., Swerdlow, N. R. Supersensitive endocrine response to physostigmine in dopamine-depleted rats - a model of depression Biological Psychiatry 1986 21:775-786 DOI:10.1016/0006-3223(86)90243-x PMID:3015269
- Swerdlow, N. R., Vaccarino, F. J., Amalric, M., Koob, G. F. The neural substrates for the motor-activating properties of psychostimulants - a review of recent findings Pharmacology, Biochemistry and Behavior 1986 25:233-248 DOI:10.1016/0091-3057(86)90261-3 PMID:2875470
- Melia, K. F., Ehlers, C. L., Lebrun, C. J., Koob, G. F. Post-learning ethanol effects on a water-finding task in rats Pharmacology, Biochemistry and Behavior 1986 24:1813-1815 DOI:10.1016/0091-3057(86)90528-9 PMID:3737649
- Britton, K. T., Lee, G., Vale, W., Rivier, J., Koob, G. F. Corticotropin releasing-factor (crf) receptor antagonist blocks activating and anxiogenic actions of crf in the rat Brain Research 1986 369:303-306 DOI:10.1016/0006-8993(86)90539-1 PMID:3008937
- Koob, G. F., Dantzer, R., Bluthe, R. M., Lebrun, C., Bloom, F. E., Lemoal, M. Central injections of arginine vasopressin prolong extinction of active-avoidance Peptides 1986 7:213-218 DOI:10.1016/0196-9781(86)90215-9 PMID:3737445
- Vaccarino, F. J., Amalric, M., Swerdlow, N. R., Koob, G. F. Blockade of amphetamine but not opiate-induced locomotion following antagonism of dopamine function in the rat Pharmacology, Biochemistry and Behavior 1986 24:61-65 DOI:10.1016/0091-3057(86)90045-6 PMID:3080760
- Swerdlow, N. R., Braff, D. L., Geyer, M. A., Koob, G. F. Central dopamine hyperactivity in rats mimics abnormal acoustic startle response in schizophrenics Biological Psychiatry 1986 21:23-33 DOI:10.1016/0006-3223(86)90005-3 PMID:3080033
- Swerdlow, N. R., Geyer, M. A., Vale, W. W., Koob, G. F. Corticotropin-releasing factor potentiates acoustic startle in rats - blockade by chlordiazepoxide Psychopharmacology 1986 88:147-152 DOI:10.1007/bf00652231 PMID:3081925
- Deyo, S. N., Shoemaker, W. J., Ettenberg, A., Bloom, F. E., Koob, G. F. Subcutaneous administration of behaviorally effective doses of arginine vasopressin change brain avp content only in median-eminence Neuroendocrinology 1986 42:260-266 DOI:10.1159/000124449 PMID:3951675
- Koob, G. F., Braestrup, C., Britton, K. T. The effects of fg-7142 and ro-15-1788 on the release of punished responding produced by chlordiazepoxide and ethanol in the rat Psychopharmacology 1986 90:173-178 PMID:3097697
- Swerdlow, N. R., Koob, G. F., Aldenhoff, J. B. The effects of verapamil on the locomotor-activating properties of corticotropin releasing-factor (crf) in the rat Psychoneuroendocrinology 1986 11:237-240 DOI:10.1016/0306-4530(86)90059-4 PMID:34892
- Vaccarino, F. J., Koob, G. F. Accumbens cholecystokinin attenuation of brain stimulation reward in the ventral tegmental area Annals of the New York Academy of Sciences 1985 448:669-670 DOI:10.1111/j.1749-6632.1985.tb29983.x
- Koob, G. F., Lebrun, C., Martinez, J. L., Dantzer, R., Lemoal, M., Bloom, F. E. Arginine vasopressin, stress, and memory Annals of the New York Academy of Sciences 1985 444:194-202 DOI:10.1111/j.1749-6632.1985.tb37589.x PMID:3860087
- Vaccarino, F. J., Bloom, F. E., Koob, G. F. Blockade of nucleus accumbens opiate receptors attenuates intravenous heroin reward in the rat Psychopharmacology 1985 86:37-42 DOI:10.1007/bf00431681 PMID:2991967
- Britton, K. T., Morgan, J., Rivier, J., Vale, W., Koob, G. F. Chlordiazepoxide attenuates response suppression induced by corticotropin-releasing factor in the conflict test Psychopharmacology 1985 86:170-174 DOI:10.1007/bf00431704 PMID:3927353
- Koob, G. F., Bloom, F. E. Corticotropin-releasing factor and behavior Federation Proceedings 1985 44:259-263 PMID:3871412
- Ehlers, C. L., Reed, T. K., Wang, M., Lebrun, C. J., Koob, G. F. EEG effects of subcutaneous and intracerebroventricular injections of arginine vasopressin in the rat Psychopharmacology 1985 87:430-433 DOI:10.1007/bf00432508 PMID:3936102
- Swerdlow, N. R., Lee, D., Koob, G. F., Vaccarino, F. J. Effects of chronic dietary lithium on behavioral indexes of dopamine denervation supersensitivity in the rat Journal of Pharmacology and Experimental Therapeutics 1985 235:324-329 PMID:3932641
- Eaves, M., Thatcherbritton, K., Rivier, J., Vale, W., Koob, G. F. Effects of corticotropin releasing-factor on locomotor-activity in hypophysectomized rats Peptides 1985 6:923-926 DOI:10.1016/0196-9781(85)90323-7 PMID:3878503
- Vaccarino, F. J., Pettit, H. O., Bloom, F. E., Koob, G. F. Effects of intracerebroventricular administration of methyl naloxonium chloride on heroin self-administration in the rat Pharmacology, Biochemistry and Behavior 1985 23:495-498 DOI:10.1016/0091-3057(85)90027-9
- Swerdlow, N. R., Vaccarino, F. J., Koob, G. F. Effects of naloxone on heroin-stimulated amphetamine-stimulated and caffeine-stimulated locomotor-activity in the rat Pharmacology, Biochemistry and Behavior 1985 23:499-501 DOI:10.1016/0091-3057(85)90028-0 PMID:4048244
- Ehlers, C. L., Koob, G. F. Locomotor behavior following kindling in three different brain sites Brain Research 1985 326:71-79 DOI:10.1016/0006-8993(85)91385-x PMID:3971150
- Amalric, M., Koob, G. F. Low-doses of methylnaloxonium in the nucleus accumbens antagonize hyperactivity induced by heroin in the rat Pharmacology, Biochemistry and Behavior 1985 23:411-415 DOI:10.1016/0091-3057(85)90014-0 PMID:4048236
- Koob, G. F., Dantzer, R., Rodriguez, F., Bloom, F. E., Lemoal, M. Osmotic-stress mimics effects of vasopressin on learned behavior Nature 1985 315:750-752 DOI:10.1038/315750a0 PMID:4010780
- Swerdlow, N. R., Koob, G. F. Separate neural substrates of the locomotor-activating properties of amphetamine, heroin, caffeine and corticotropin releasing-factor (crf) in the rat Pharmacology, Biochemistry and Behavior 1985 23:303-307 DOI:10.1016/0091-3057(85)90574-x PMID:3877311
- Vaccarino, F. J., Bloom, F. E., Rivier, J., Vale, W., Koob, G. F. Stimulation of food-intake in rats by centrally administered hypothalamic growth hormone-releasing factor Nature 1985 314:167-168 DOI:10.1038/314167a0 PMID:3919314
- Ehlers, C. L., Koob, G. F. The effects of chronic lithium on the EEG and locomotor response to drug challenge in rats Progress in Neuro-Psychopharmacology & Biological Psychiatry 1985 9:133-142 DOI:10.1016/0278-5846(85)90075-2 PMID:4001429
- Lebrun, C., Lemoal, M., Koob, G. F., Bloom, F. E. Vasopressin pressor antagonist injected centrally reverses behavioral-effects of peripheral injection of vasopressin, but only at doses that reverse increase in blood-pressure Regulatory Peptides 1985 11:173-181 DOI:10.1016/0167-0115(85)90077-1 PMID:4035008
- Lebrun, C. J., Rigter, H., Martinez, J. L., Koob, G. F., Lemoal, M., Bloom, F. E. Antagonism of effects of vasopressin (avp) on inhibitory avoidance by a vasopressin antagonist peptide dptyr(me)avp Life Sciences 1984 35:1505-1512 DOI:10.1016/0024-3205(84)90168-1 PMID:6482669
- Lemoal, M., Dantzer, R., Mormede, P., Baduel, A., Lebrun, C., Ettenberg, A., Vanderkooy, D., Wenger, J., Deyo, S., Koob, G. F., Bloom, F. E. Behavioral-effects of peripheral administration of arginine vasopressin - a review of our search for a mode of action and a hypothesis Psychoneuroendocrinology 1984 9:319-341 DOI:10.1016/0306-4530(84)90042-8 PMID:6514931
- Britton, D. R., Ksir, C., Britton, K. T., Young, D., Koob, G. F. Brain norepinephrine depleting lesions selectively enhance behavioral responsiveness to novelty Physiology & Behavior 1984 33:473-478 DOI:10.1016/0031-9384(84)90171-9 PMID:6440160
- Astonjones, S., Astonjones, G., Koob, G. F. Cocaine antagonizes anxiolytic effects of ethanol Psychopharmacology 1984 84:28-31 DOI:10.1007/bf00432019 PMID:6149593
- Moss, D. E., Koob, G. F., McMaster, S. B., Janowsky, D. S. Comparative effects of tetrahydrocannabinol on psychostimulant-induced behaviors Pharmacology, Biochemistry and Behavior 1984 21:641-644 PMID:6150497
- Pettit, H. O., Ettenberg, A., Bloom, F. E., Koob, G. F. Destruction of dopamine in the nucleus accumbens selectively attenuates cocaine but not heroin self-administration in rats Psychopharmacology 1984 84:167-173 DOI:10.1007/bf00427441 PMID:6438676
- Koob, G. F., Thatcherbritton, K., Britton, D. R., Roberts, D. C. S., Bloom, F. E. Destruction of the locus coeruleus or the dorsal ne bundle does not alter the release of punished responding by ethanol and chlordiazepoxide Physiology & Behavior 1984 33:479-485 DOI:10.1016/0031-9384(84)90172-0 PMID:6542682
- Ettenberg, A., Koob, G. F. Different effects of cholecystokinin and satiety on lateral hypothalamic self-stimulation Physiology & Behavior 1984 32:127-130 DOI:10.1016/0031-9384(84)90083-0 PMID:6718524
- Britton, K. T., Svensson, T., Schwartz, J., Bloom, F. E., Koob, G. F. Dorsal noradrenergic bundle lesions fail to alter opiate withdrawal or suppression of opiate withdrawal by clonidine Life Sciences 1984 34:133-139 DOI:10.1016/0024-3205(84)90583-6 PMID:6537983
- Koob, G. F., Swerdlow, N., Seeligson, M., Eaves, M., Sutton, R., Rivier, J., Vale, W. Effects of alpha-flupenthixol and naloxone on crf-induced locomotor activation Neuroendocrinology 1984 39:459-464 DOI:10.1159/000124021 PMID:6096752
- Koob, G. F., Pettit, H. O., Ettenberg, A., Bloom, F. E. Effects of opiate antagonists and their quaternary derivatives on heroin self-administration in the rat Journal of Pharmacology and Experimental Therapeutics 1984 229:481-486 PMID:6716270
- Swerdlow, N. R., Swanson, L. W., Koob, G. F. Electrolytic lesions of the substantia innominata and lateral preoptic area attenuate the 'supersensitive' locomotor response to apomorphine resulting from denervation of the nucleus accumbens Brain Research 1984 306:141-148 DOI:10.1016/0006-8993(84)90362-7 PMID:6087974
- Vaccarino, F. J., Koob, G. F. Microinjections of nanogram amounts of sulfated cholecystokinin octapeptide into the rat nucleus accumbens attenuates brain-stimulation reward Neuroscience Letters 1984 52:61-66 DOI:10.1016/0304-3940(84)90351-3 PMID:6098878
- Koob, G. F., Simon, H., Herman, J. P., Lemoal, M. Neuroleptic-like disruption of the conditioned avoidance-response requires destruction of both the mesolimbic and nigrostriatal dopamine systems Brain Research 1984 303:319-329 DOI:10.1016/0006-8993(84)91218-6 PMID:6430466
- Swerdlow, N. R., Koob, G. F. Restrained rats learn amphetamine-conditioned locomotion, but not place preference Psychopharmacology 1984 84:163-166 DOI:10.1007/bf00427440 PMID:6438675
- Swerdlow, N. R., Swanson, L. W., Koob, G. F. Substantia innominata - critical link in the behavioral expression of mesolimbic dopamine stimulation in the rat Neuroscience Letters 1984 50:19-24 DOI:10.1016/0304-3940(84)90455-5 PMID:6493625
- Swerdlow, N. R., Koob, G. F. The neural substrates of apomorphine-stimulated locomotor-activity following denervation of the nucleus accumbens Life Sciences 1984 35:2537-2544 DOI:10.1016/0024-3205(84)90440-5 PMID:6096659
- Koob, G. F., Bloom, F. E. Behavioral effects of opioid peptides British Medical Bulletin 1983 39:89-94 PMID:6340789
- Ettenberg, A., Vanderkooy, D., Lemoal, M., Koob, G. F., Bloom, F. E. Can aversive properties of (peripherally-injected) vasopressin account for its putative role in memory Behavioural Brain Research 1983 7:331-350 DOI:10.1016/0166-4328(83)90024-4 PMID:6838716
- Vale, W., Rivier, C., Brown, M. R., Spiess, J., Koob, G., Swanson, L., Bilezikjian, L., Bloom, F., Rivier, J. Chemical and biological characterization of corticotropin releasing-factor Recent Progress in Hormone Research 1983 39:245-270 PMID:6314446
- Swerdlow, N. R., Vanderkooy, D., Koob, G. F., Wenger, J. R. Cholecystokinin produces conditioned place-aversions, not place-preferences, in food-deprived rats - evidence against involvement in satiety Life Sciences 1983 32:2087-2093 DOI:10.1016/0024-3205(83)90096-6 PMID:6843283
- Robbins, T. W., Roberts, D. C. S., Koob, G. F. Effects of d-amphetamine and apomorphine upon operant-behavior and schedule-induced licking in rats with 6-hydroxydopamine-induced lesions of the nucleus accumbens Journal of Pharmacology and Experimental Therapeutics 1983 224:662-673 PMID:6402587
- Vanderkooy, D., Swerdlow, N. R., Koob, G. F. Paradoxical reinforcing properties of apomorphine - effects of nucleus accumbens and area postrema lesions Brain Research 1983 259:111-118 PMID:6824923
- Ehlers, C. L., Indik, J. H., Koob, G. F., Bloom, F. E. The effect of single and repeated electroconvulsive shock (ECS) on locomotor-activity in rats Progress in Neuro-Psychopharmacology & Biological Psychiatry 1983 7:217-222 DOI:10.1016/0278-5846(83)90110-0 PMID:6684316
- Ettenberg, A., Koob, G. F., Bloom, F. E. Time course of alpha-flupenthixol action explains response artifacts of neuroleptic action on brain-stimulation reward - reply Science 1983 222:1253-1254 DOI:10.1126/science.222.4629.1253-a
- Ettenberg, A., Lemoal, M., Koob, G. F., Bloom, F. E. Vasopressin potentiation in the performance of a learned appetitive task - reversal by a pressor antagonist analog of vasopressin Pharmacology, Biochemistry and Behavior 1983 18:645-647 DOI:10.1016/0091-3057(83)90294-0 PMID:6867069
- Strecker, R. E., Roberts, D. C. S., Koob, G. F. Apomorphine-induced facilitation of intra-cranical self-stimulation following dopamine denervation of the nucleus accumbens Pharmacology, Biochemistry and Behavior 1982 17:1015-1018 DOI:10.1016/0091-3057(82)90487-7 PMID:6817349
- Koob, G. F., Bloom, F. E. Behavioral-effects of neuropeptides - endorphins and vasopressin Annual Review of Physiology 1982 44:571-582 DOI:10.1146/annurev.ph.44.030182.003035 PMID:7041806
- Schwartz, J. M., Ksir, C., Koob, G. F., Bloom, F. E. Changes in locomotor response to beta-endorphin microinfusion during and after opiate abstinence syndrome - a proposal for a model of the onset of mania Psychiatry Research 1982 7:153-161 DOI:10.1016/0165-1781(92)90088-k PMID:6292980
- Sutton, R. E., Koob, G. F., Lemoal, M., Rivier, J., Vale, W. Corticotropin releasing-factor produces behavioral activation in rats Nature 1982 297:331-333 DOI:10.1038/297331a0 PMID:6978997
- Roberts, D. C. S., Koob, G. F. Disruption of cocaine self-administration following 6-hydroxydopamine lesions of the ventral tegmental area in rats Pharmacology, Biochemistry and Behavior 1982 17:901-904 DOI:10.1016/0091-3057(82)90469-5 PMID:6817350
- Staunton, D. A., Magistretti, P. J., Koob, G. F., Shoemaker, W. J., Bloom, F. E. Dopaminergic super-sensitivity induced by denervation and chronic receptor blockade is additive Nature 1982 299:72-74 DOI:10.1038/299072a0 PMID:7110328
- Ettenberg, A., Pettit, H. O., Bloom, F. E., Koob, G. F. Heroin and cocaine intravenous self-administration in rats - mediation by separate neural systems Psychopharmacology 1982 78:204-209 DOI:10.1007/bf00428151 PMID:6296898
- Britton, D. R., Koob, G. F., Rivier, J., Vale, W. Intraventricular corticotropin-releasing factor enhances behavioral-effects of novelty Life Sciences 1982 31:363-367 DOI:10.1016/0024-3205(82)90416-7 PMID:6983018
- Ehlers, C. L., Koob, G. F., Bloom, F. E. Post-ictal locomotor-activity in 3 different rat models of epilepsy Brain Research 1982 250:178-182 DOI:10.1016/0006-8993(82)90966-0 PMID:7139314
- Fray, P. J., Koob, G. F., Iversen, S. D. Tail-pinch-elicited behavior in rats - preference, plasticity, and learning Behavioral and Neural Biology 1982 36:108-125 DOI:10.1016/s0163-1047(82)90112-1 PMID:7183308
- Koob, G. F. The dopamine anhedonia hypothesis - a pharmacological phrenology Behavioral and Brain Sciences 1982 5:63-64
- Joyce, E. M., Koob, G. F. Amphetamine-induced, scopolamine-induced and caffeine-induced locomotor-activity following 6-hydroxydopamine lesions of the mesolimbic dopamine system Psychopharmacology 1981 73:311-313 DOI:10.1007/bf00426456 PMID:6789349
- Koob, G. F., Lemoal, M., Gaffori, O., Manning, M., Sawyer, W. H., Rivier, J., Bloom, F. E. Arginine vasopressin and a vasopressin antagonist peptide - opposite effects on extinction of active-avoidance in rats Regulatory Peptides 1981 2:153-163 DOI:10.1016/0167-0115(81)90009-4 PMID:7255768
- Ettenberg, A., Rogers, J., Koob, G. F., Bloom, F. E. Endogenous opiates and fasting Science 1981 213:1282-1282 DOI:10.1126/science.6267697 PMID:6267697
- Koob, G. F., Stinus, L., Lemoal, M. Hyperactivity and hypoactivity produced by lesions to the mesolimbic dopamine system Behavioural Brain Research 1981 3:341-359 DOI:10.1016/0166-4328(81)90004-8 PMID:6796098
- Ettenberg, A., Koob, G. F., Bloom, F. E. Response artifact in the measurement of neuroleptic-induced anhedonia Science 1981 213:357-359 DOI:10.1126/science.7244622 PMID:7244622
- Joyce, E. M., Koob, G. F., Strecker, R., Iversen, S. D., Bloom, F. E. The behavioral-effects of enkephalin analogs injected into the ventral tegmental area and globus pallidus Brain Research 1981 221:359-370 DOI:10.1016/0006-8993(81)90784-8 PMID:7025963
- Lemoal, M., Koob, G. F., Koda, L. Y., Bloom, F. E., Manning, M., Sawyer, W. H., Rivier, J. Vasopressor receptor antagonist prevents behavioral-effects of vasopressin Nature 1981 291:491-493 PMID:7231561
- Fray, P. J., Sahakian, B. J., Robbins, T. W., Koob, G. F., Iversen, S. D. An observational method for quantifying the behavioral-effects of dopamine agonists - contrasting effects of d-amphetamine and apomorphine Psychopharmacology 1980 69:253-259 DOI:10.1007/bf00433091 PMID:6774363
- Sessions, G. R., Meyerhoff, J. L., Kant, G. J., Koob, G. F. Effects of lesions of the ventral medial tegmentum on locomotor-activity, biogenic-amines and response to amphetamine in rats Pharmacology, Biochemistry and Behavior 1980 12:603-608 PMID:7393956
- Roberts, D. C. S., Koob, G. F., Klonoff, P., Fibiger, H. C. Extinction and recovery of cocaine self-administration following 6-hydroxydopamine lesions of the nucleus accumbens Pharmacology, Biochemistry and Behavior 1980 12:781-787 DOI:10.1016/0091-3057(80)90166-5 PMID:7393973
- Stinus, L., Koob, G. F., Ling, N., Bloom, F. E., Lemoal, M. Locomotor activation induced by infusion of endorphins into the ventral tegmental area - evidence for opiate-dopamine interactions Proceedings of the National Academy of Sciences of the United States of America-Biological Sciences 1980 77:2323-2327 DOI:10.1073/pnas.77.4.2323 PMID:6929553
- Robbins, T. W., Koob, G. F. Selective disruption of displacement behavior by lesions of the mesolimbic dopamine system Nature 1980 285:409-412 DOI:10.1038/285409a0 PMID:6104303
- Lemoal, M., Koob, G. F., Bloom, F. E. Endorphins and extinction - differential actions on appetitive and adversive tasks Life Sciences 1979 24:1631-1636 DOI:10.1016/0024-3205(79)90245-5 PMID:481097
- Koob, G. F., Riley, S. J., Smith, S. C., Robbins, T. W. Effects of 6-hydroxydopamine lesions of nucleus accumbens septi and olfactory tubercle on feeding, locomotor-activity, and amphetamine anorexia in rat Journal of Comparative and Physiological Psychology 1978 92:917-927 DOI:10.1037/h0077542 PMID:282297
- Koob, G. F., Kelley, A. E., Mason, S. T. Locus coeruleus lesions - learning and extinction Physiology & Behavior 1978 20:709-716 DOI:10.1016/0031-9384(78)90296-2 PMID:684108
- Emson, P. C., Koob, G. F. Origin and distribution of dopamine-containing afferents to rat frontal cortex Brain Research 1978 142:249-267 DOI:10.1016/0006-8993(78)90634-0 PMID:24492
- Robbins, T. W., Koob, G. F. Pipradrol enhances reinforcing properties of stimuli paired with brain-stimulation Pharmacology, Biochemistry and Behavior 1978 8:219-222 DOI:10.1016/0091-3057(78)90308-8 PMID:26063
- Sahakian, B. J., Koob, G. F. Relationship between pipradrol-induced responding for electrical brain-stimulation, stereotyped behavior and locomotor-activity Neuropharmacology 1978 17:363-366 DOI:10.1016/0028-3908(78)90007-2 PMID:27732
- Koob, G. F., Fray, P. J., Iversen, S. D. Self-stimulation at lateral hypothalamus and locus coeruleus after specific unilateral lesions of dopamine system Brain Research 1978 146:123-140 DOI:10.1016/0006-8993(78)90222-6 PMID:647383
- Koob, G. F., Delfiacco, M., Iversen, S. D. Spontaneous and amphetamine-induced behavior after bilateral injection of ethanolamine-o-sulfate into substantia nigra Brain Research 1978 146:313-323 DOI:10.1016/0006-8993(78)90976-9 PMID:565665
- Koda, L. Y., Koob, G. F., Shier, W. T., Bloom, F. E. Tetrahydropapaveroline induces small granular vesicles in brain dopamine fibers Nature 1978 276:281-283 DOI:10.1038/276281a0 PMID:714160
- Koob, G. F., Winger, G. D., Meyerhoff, J. L., Annau, Z. Effects of d-amphetamine on concurrent self-stimulation of forebrain and brain-stem loci Brain Research 1977 137:109-126 DOI:10.1016/0006-8993(77)91015-0 PMID:303535
- Koob, G. F. Incentive shifts in intracranial self-stimulation produced by different series of stimulus-intensity presentations Physiology & Behavior 1977 18:131-135 DOI:10.1016/0031-9384(77)90104-4 PMID:410045
- Koob, G. F., Sessions, G. R., Kant, G. J., Meyerhoff, J. L. Dissociation of hyperdipsia from destruction of locus coeruleus in rats Brain Research 1976 116:339-345 DOI:10.1016/0006-8993(76)90914-8 PMID:974779
- Koob, G. F., Balcom, G. J., Meyerhoff, J. L. Increases in intracranial self-stimulation in posterior hypothalamus following unilateral lesions in locus coeruleus Brain Research 1976 101:554-560 DOI:10.1016/0006-8993(76)90478-9 PMID:942689
- Sessions, G. R., Kant, G. J., Koob, G. F. Locus coeruleus lesions and learning in rat Physiology & Behavior 1976 17:853-859 DOI:10.1016/0031-9384(76)90053-6 PMID:1026995
- Koob, G. F., Fray, P. J., Iversen, S. D. Tail-pinch stimulation - sufficient motivation for learning Science 1976 194:637-639 DOI:10.1126/science.982032 PMID:982032
- Koob, G. F., Balcom, G. J., Meyerhoff, J. L. Dopamine and norepinephrine levels in nucleus accumbens, olfactory tubercle and corpus striatum following lesions in ventral tegmental area Brain Research 1975 94:45-55 DOI:10.1016/0006-8993(75)90875-6 PMID:1148866
- Koob, G. F., Spector, N. H., Meyerhoff, J. L. Effects of heroin on lever pressing for intracranial self-stimulation, food and water in rat Psychopharmacologia 1975 42:231-234 DOI:10.1007/bf00421261 PMID:1161980
- Koob, G. F., Annau, Z. Behavioral and neurochemical alterations induced by hypoxia in rats American Journal of Physiology 1974 227:73-78 PMID:4843358
- Koob, G. F., Annau, Z., Rubin, R. J., Montgomery, M. R. Effect of hypoxic hypoxia and carbon monoxide on food intake, water intake, and body weight in two strains of rats Life Sciences 1974 14:1511-1520 DOI:10.1016/0024-3205(74)90162-3 PMID:4829542
- Annau, Z., Heffner, R., Koob, G. F. Electrical self-stimulation of single and multiple loci - long-term observations Physiology & Behavior 1974 13:281-290 DOI:10.1016/0031-9384(74)90046-8 PMID:4413200
- Koob, G. F., Annau, Z. Effect of hypoxia on hypothalamic mechanisms American Journal of Physiology 1973 224:1403-1408 PMID:4576261
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chapter
- Koob, G. F., Le Moal, M. Addiction and the brain antireward system Annual Review of Psychology. 29-53. 2008 DOI:10.1146/annurev.psych.59.103006.093548
- Amalric, M., Koob, G. F. Functionally selective neurochemical afferents and efferents of the mesocorticolimbic and nigrostriatal dopamine system Chemical signalling in the basal ganglia. 209-226. 1993
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thesis