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Kono, Dwight
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Kono, Dwight

Faculty Member
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Positions

  • 2017 - Professor of Immunology and Microbiology, Immunology and Microbiology , Scripps Research
  • 1989 - Faculty Member, Skaggs Graduate School of Chemical and Biological Sciences , Scripps Research
  • 1988 - 2017 Professor of Immunology, Immunology and Microbial Science (IMS) , Scripps Research
Dr. Dwight Kono is investigating the pathogenesis of systemic lupus erythematosus and mercury-induced autoimmunity as well as seeking to identify new potential therapeutic targets through novel approaches; his main interest is to define both predisposing genes and genes critical for disease development.

Contact

  • dkono@scripps.edu

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  • Dwight Kono, M.D.
  • Kono Lab
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Publications

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    • Mayeux, J. M., Kono, D. H., Pollard, K. M. Development of experimental silicosis in inbred and outbred mice depends on instillation volume Scientific Reports  2019 9  DOI:10.1038/s41598-019-50725-9  PMID:31578388
    • Pollard, K. M., Cauvi, D. M., Toomey, C. B., Hultman, P., Kono, D. H. Mercury-induced inflammation and autoimmunity Biochimica Et Biophysica Acta-General Subjects  2019 1863  DOI:10.1016/j.bbagen.2019.02.001  PMID:30742953  PMCID:PMC6689266
    • Gonzalez-Quintial, R., Mayeux, J. M., Kono, D. H., Theofilopoulos, A. N., Pollard, K. M., Baccala, R. Silica exposure and chronic virus infection synergistically promote lupus-like systemic autoimmunity in mice with low genetic predisposition Clinical Immunology  2019 205:75-82  DOI:10.1016/j.clim.2019.06.003  PMID:31175964  PMCID:PMC6646094
    • Gonzalez-Quintial, R., Nguyen, A., Kono, D. H., Oldstone, M. B. A., Theofilopoulos, A. N., Baccala, R. Lupus acceleration by a MAVS-activating RNA virus requires endosomal TLR signaling and host genetic predisposition PLoS One  2018 13  DOI:10.1371/journal.pone.0203118  PMID:30199535  PMCID:PMC6130858
    • Mayeux, J. M., Escalante, G. M., Christy, J. M., Pawar, R. D., Kono, D. H., Pollard, K. M. Silicosis and silica-induced autoimmunity in the diversity outbred mouse Frontiers in Immunology  2018 9  DOI:10.3389/fimmu.2018.00874  PMID:29755467  PMCID:PMC5932595
    • Theofilopoulos, A. N., Kono, D. H., Baccala, R. The multiple pathways to autoimmunity Nature Immunology  2017 18:716-724  DOI:10.1038/ni.3731  PMID:28632714
    • Lawson, B. R., Gonzalez-Quintial, R., Eleftheriadis, T., Farrar, M. A., Miller, S. D., Sauer, K., McGavern, D. B., Kono, D. H., Baccala, R., Theofilopoulos, A. N. Interleukin-7 is required for CD4(+) T cell activation and autoimmune neuroinflammation Clinical Immunology  2015 161:260-269  DOI:10.1016/j.clim.2015.08.007  PMID:26319414  PMCID:PMC4658267
    • Maine, C. J., Marquardt, K., Scatizzi, J. C., Pollard, K. M., Kono, D. H., Sherman, L. A. The effect of the autoimmunity-associated gene, PTPN22, on a BXSB-derived model of lupus Clinical Immunology  2015 156:65-73  DOI:10.1016/j.clim.2014.11.003  PMID:25463433  PMCID:PMC4291082
    • Cauvi, D. M., Gabriel, R., Kono, D. H., Hultman, P., Pollard, K. M. A tandem repeat in decay accelerating factor 1 is associated with severity of murine mercury-induced autoimmunity Autoimmune Diseases  2014 2014:260613  DOI:10.1155/2014/260613  PMID:24818014  PMCID:PMC4003777
    • Pollard, K. M., Kono, D. H. Requirements for "Fire and ICE" differ between animal models of autoimmunity: comment on the article by Kahlenberg et al Arthritis & Rheumatology  2014 66:2310-2311  DOI:10.1002/art.38678  PMID:24757010
    • Tardif, V., Manenkova, Y., Berger, M., Hoebe, K., Zuo, J. P., Yuan, C., Kono, D. H., Theofilopoulos, A. N., Lawson, B. R. Critical role of transmethylation in TLR signaling and systemic lupus erythematosus Clinical Immunology  2013 147:133-143  DOI:10.1016/j.clim.2013.02.018  PMID:23583916  PMCID:PMC3634912
    • Baccala, R., Gonzalez-Quintial, R., Blasius, A. L., Rimann, I., Ozato, K., Kono, D. H., Beutler, B., Theofilopoulos, A. N. Essential requirement for IRF8 and SLC15A4 implicates plasmacytoid dendritic cells in the pathogenesis of lupus Proceedings of the National Academy of Sciences of the United States of America  2013 110:2940-2945  DOI:10.1073/pnas.1222798110  PMID:23382217  PMCID:PMC3581947
    • Pollard, K. M., Cauvi, D. M., Toomey, C. B., Morris, K. V., Kono, D. H. Interferon-gamma and systemic autoimmunity Discovery Medicine  2013 87:123-131  PMID:23998448  PMCID:PMC3934799
    • Pollard, K. M., Kono, D. H. Requirements for innate immune pathways in environmentally induced autoimmunity BMC Medicine  2013 11:100  DOI:10.1186/1741-7015-11-100  PMID:23557436  PMCID:PMC3616845
    • Pollard, K. M., Kono, D. H. Requirements for innate immune pathways in environmentally induced autoimmunity BMC Medicine  2013 11:100  DOI:10.1186/1741-7015-11-100  PMID:23557436  PMCID:PMC3616845
    • Koh, Y. T., Scatizzi, J. C., Gahan, J. D., Lawson, B. R., Baccala, R., Pollard, K. M., Beutler, B. A., Theofilopoulos, A. N., Kono, D. H. Role of nucleic acid-sensing TLRs in diverse autoantibody specificities and anti-nuclear antibody-producing B cells Journal of Immunology  2013 190:4982-4990  DOI:10.4049/jimmunol.1202986  PMID:23589617  PMCID:PMC3729324
    • Kono, D. H., Baccala, R., Theofilopoulos, A. N. TLRs and interferons: a central paradigm in autoimmunity Current Opinion in Immunology  2013 25:720-727  DOI:10.1016/j.coi.2013.10.006  PMID:24246388  PMCID:PMC4309276
    • Germolec, D., Kono, D. H., Pfau, J. C., Pollard, K. M. Animal models used to examine the role of the environment in the development of autoimmune disease: Findings from an NIEHS Expert Panel Workshop Journal of Autoimmunity  2012 39:285-293  DOI:10.1016/j.jaut.2012.05.020  PMID:22748431  PMCID:PMC3465484
    • Baccala, R., Gonzalez-Quintial, R., Schreiber, R. D., Lawson, B. R., Kono, D. H., Theofilopoulos, A. N. Anti-IFN-alpha/beta receptor antibody treatment ameliorates disease in lupus-predisposed mice Journal of Immunology  2012 189:5976-5984  DOI:10.4049/jimmunol.1201477  PMID:23175700  PMCID:PMC3530925
    • Pollard, K. M., Hultman, P., Toomey, C. B., Cauvi, D. M., Hoffman, H. M., Hamel, J. C., Kono, D. H. Definition of IFN-γ-related pathways critical for chemically-induced systemic autoimmunity Journal of Autoimmunity  2012 39:323-331  DOI:10.1016/j.jaut.2012.04.003  PMID:22578563  PMCID:PMC3570757
    • Gronwall, C., Chen, Y. F., Vas, J., Khanna, S., Thiel, S., Corr, M., Kono, D. H., Silverman, G. J. MAPK phosphatase-1 is required for regulatory natural autoantibody-mediated inhibition of TLR responses Proceedings of the National Academy of Sciences of the United States of America  2012 109:19745-19750  DOI:10.1073/pnas.1211868109  PMID:23139409  PMCID:PMC3511709
    • Scatizzi, J. C., Haraldsson, M. K., Pollard, K. M., Theofilopoulos, A. N., Kono, D. H. The lbw2 locus promotes autoimmune hemolytic anemia Journal of Immunology  2012 188:3307-3314  DOI:10.4049/jimmunol.1103561  PMID:22371393  PMCID:PMC3311724
    • Lawson, B. R., Eleftheriadis, T., Tardif, V., Gonzalez-Quintial, R., Baccala, R., Kono, D. H., Theofilopoulos, A. N. Transmethylation in immunity and autoimmunity Clinical Immunology  2012 143:8-21  DOI:10.1016/j.clim.2011.10.007  PMID:22364920  PMCID:PMC3780779
    • Theofilopoulos, A. N., Kono, D. H., Beutler, B., Baccala, R. Intracellular nucleic acid sensors and autoimmunity Journal of Interferon and Cytokine Research  2011 31:867-886  DOI:10.1089/jir.2011.0092  PMID:22029446  PMCID:PMC3234494
    • Gonzalez-Quintial, R., Lawson, B. R., Scatizzi, J. C., Craft, J., Kono, D. H., Baccala, R., Theofilopoulos, A. N. Systemic autoimmunity and lymphoproliferation are associated with excess IL-7 and inhibited by IL-7R alpha blockade PLoS One  2011 6:e27528  DOI:10.1371/journal.pone.0027528  PMID:22102903  PMCID:PMC3213145
    • Ait-Azzouzene, D., Kono, D. H., Gonzalez-Quintial, R., McHeyzer-Williams, L. J., Lim, M., Wickramarachchi, D., Gerdes, T., Gavin, A. L., Skog, P., McHeyzer-Williams, M. G., Nemazee, D., Theofilopoulos, A. N. Deletion of IgG-switched autoreactive B cells and defects in Fas(lpr) lupus mice Journal of Immunology  2010 185:1015-1027  DOI:10.4049/jimmunol.1000698  PMID:20554953  PMCID:PMC3641794
    • Wickramarachchi, D. C., Theofilopoulos, A. N., Kono, D. H. Immune pathology associated with altered actin cytoskeleton regulation Autoimmunity  2010 43:64-75  DOI:10.3109/08916930903374634  PMID:20001423  PMCID:PMC3660107
    • Arandjelovic, S., Wickramarachchi, D., Hemmers, S., Leming, S. S., Kono, D. H., Mowen, K. A. Mast cell function is not altered by Coronin-1A deficiency Journal of Leukocyte Biology  2010 88:737-745  DOI:10.1189/jlb.0310131  PMID:20643816  PMCID:PMC2974433
    • Theofilopoulos, A. N., Gonzalez-Quintial, R., Lawson, B. R., Koh, Y. T., Stern, M. E., Kono, D. H., Beutler, B., Baccala, R. Sensors of the innate immune system: Their link to rheumatic diseases Nature Reviews Rheumatology  2010 6:146-156  DOI:10.1038/nrrheum.2009.278  PMID:20142813  PMCID:PMC4437225
    • Pollard, K. M., Hultman, P., Kono, D. H. Toxicology of autoimmune diseases Chemical Research in Toxicology  2010 23:455-466  DOI:10.1021/tx9003787  PMID:20078109  PMCID:PMC3076021
    • Kono, D. H., Haraldsson, M. K., Lawson, B. R., Pollard, K. M., Koh, Y. T., Du, X., Arnold, C. N., Baccala, R., Silverman, G. J., Beutler, B. A., Theofilopoulos, A. N. Endosomal TLR signaling is required for anti-nucleic acid and rheumatoid factor autoantibodies in lupus Proceedings of the National Academy of Sciences of the United States of America  2009 106:12061-12066  DOI:10.1073/pnas.0905441106  PMID:19574451  PMCID:PMC2715524
    • Odegard, J. M., DiPlacido, L. D., Greenwald, L., Kashgarian, M., Kono, D. H., Dong, C., Flavell, R. A., Craft, J. ICOS controls effector function but not trafficking receptor expression of kidney-infiltrating effector T cells in murine lupus Journal of Immunology  2009 182:4076-4084  DOI:10.4049/jimmunol.0800758  PMID:19299705  PMCID:PMC2746004
    • Chen, Y. F., Khanna, S., Goodyear, C. S., Park, Y. B., Raz, E., Thiel, S., Gronwall, C., Vas, J., Boyle, D. L., Corr, M., Kono, D. H., Silverman, G. J. Regulation of dendritic cells and macrophages by an anti-apoptotic cell natural antibody that suppresses TLR responses and inhibits inflammatory arthritis Journal of Immunology  2009 183:1346-1359  DOI:10.4049/jimmunol.0900948  PMID:19564341  PMCID:PMC2713016
    • Baccala, R., Gonzalez-Quintial, R., Lawson, B. R., Stern, M. E., Kono, D. H., Beutler, B., Theofilopoulos, A. N. Sensors of the innate immune system: Their mode of action Nature Reviews Rheumatology  2009 5:448-456  DOI:10.1038/nrrheum.2009.136  PMID:19597511
    • Odegard, J. M., Marks, B. R., DiPlacido, L. D., Poholek, A. C., Kono, D. H., Dong, C., Flavell, R. A., Craft, J. ICOS-dependent extrafollicular helper T cells elicit igg production via IL-21 in systemic autoimmunity Journal of Experimental Medicine  2008 205:2873-2886  DOI:10.1084/jem.20080840  PMID:18981236  PMCID:PMC2585848
    • Haraldsson, M. K., Louis-Dit-Sully, C. A., Lawson, B. R., Sternik, G., Santiago-Raber, M. L., Gascoigne, N. R. J., Theofilopoulos, A. N., Kono, D. H. The lupus-related Lmb3 locus contains a disease-suppressing coronin-1A gene mutation Immunity  2008 28:40-51  DOI:10.1016/j.immuni.2007.11.023  PMID:18199416  PMCID:PMC2274909
    • Santiago-Raber, M. L., Haraldsson, M. K., Theofilopoulos, A. N., Kono, D. H. Characterization of reciprocal MRL-Fas(lpr) and C57BL/6-Fas(lpr) congenic mice reveals significant effects from Lmb3 Journal of Immunology  2007 178:8195-8202  PMID:17548658
    • Baccala, R., Hoebe, K., Kono, D. H., Beutler, B., Theofilopoulos, A. N. TLR-dependent and TLR-independent pathways of type I interferon induction in systemic autoimmunity Nature Medicine  2007 13:543-551  DOI:10.1038/nm1590  PMID:17479100
    • Kono, D. H., Theofilopoulos, A. N. Genetics of SLE in mice Springer Seminars in Immunopathology  2006 28:83-96  DOI:10.1007/s00281-006-0030-7  PMID:16972052
    • Watson, L. C., Moffatt-Blue, C. S., McDonald, R. Z., Kompfner, E., Ait-Azzouzene, D., Nemazee, D., Theofilopoulos, A. N., Kono, D. H., Feeney, A. J. Paucity of V-D-D-J rearrangements and V-H replacement events in lupus prone and nonautoimmune TdT(-/-) and TdT(+/+) mice Journal of Immunology  2006 177:1120-1128  PMID:16818769
    • Haraldsson, M. K., dela Paz, N. G., Kuan, J. G., Gilkeson, G. S., Theofilopoulos, A. N., Kono, D. H. Autoimmune alterations induced by the New Zealand Black Lbw2 locus in BWF1 mice Journal of Immunology  2005 174:5065-5073  PMID:15814738
    • Pollard, K. M., Hultman, P., Kono, D. H. Immunology and genetics of induced systemic autoimmunity Autoimmunity Reviews  2005 4:282-288  DOI:10.1016/j.autrev.2004.12.005  PMID:15990075
    • Baccala, R., Kono, D. H., Theofilopoulos, A. N. Interferons as pathogenic effectors in autoimmunity Immunological Reviews  2005 204:9-26  DOI:10.1111/j.0105-2896.2005.00252.x  PMID:15790347
    • Theofilopoulos, A. N., Baccala, R., Beutler, B., Kono, D. H. Type I interferons (α/β) in immunity and autoimmunity Annual Review of Immunology  2005 23:307-336  DOI:10.1146/annurev.immunol.23.021704.115843  PMID:15771573
    • Pollard, K. M., Arnush, M., Hultman, P., Kono, D. H. Costimulation requirements of induced murine systemic autoimmune disease Journal of Immunology  2004 173:5880-5887  PMID:15494542
    • Lawson, B. R., Baccala, R., Song, J. X., Croft, M., Kono, D. H., Theofilopoulos, A. N. Deficiency of the cyclin kinase inhibitor P21(WAF-1/CIP-1) promotes apoptosis of activated/memory T cells and inhibits spontaneous systemic autoirnmunity Journal of Experimental Medicine  2004 199:547-557  DOI:10.1084/jem.20031685  PMID:14970181  PMCID:PMC2211831
    • Robey, I. F., Peterson, M., Horwitz, M. S., Kono, D. H., Stratmann, T., Theofilopoulos, A. N., Sarvetnick, N., Teyton, L., Feeney, A. J. Terminal deoxynucleotidyltransferase deficiency decreases autoimmune disease in diabetes-prone nonobese diabetic mice and lupus-prone MRL-Fas(lpr) mice Journal of Immunology  2004 172:4624-4629  PMID:15034081
    • Kono, D. H., Park, M. S., Theofilopoulos, A. N. Genetic complementation in female (BXSB x NZW)F-2 mice Journal of Immunology  2003 171:6442-6447  PMID:14662843
    • Kono, D. H., Baccala, R., Theofilopoulos, A. N. Inhibition of lupus by genetic alteration of the interferon-alpha/beta receptor Autoimmunity  2003 36:503-510  DOI:10.1080/08916930310001624665  PMID:14984027
    • Santiago-Raber, M. L., Baccala, R., Haraldsson, K. M., Choubey, D., Stewart, T. A., Kono, D. H., Theofilopoulos, A. N. Type-I interferon receptor deficiency reduces lupus-like disease in NZB mice Journal of Experimental Medicine  2003 197:777-788  DOI:10.1084/jem.20021996  PMID:12642605  PMCID:PMC2193854
    • Pollard, K. M., Hultman, P., Kono, D. H. Using single-gene deletions to identify checkpoints in the progression of systemic autoimmunity Annals of the New York Academy of Sciences  2003 987:236-239  PMID:12727644
    • Theofilopoulos, A. N., Kono, D. H. A genetic analysis of lupus Allergy  2002 57:67-74  DOI:10.1034/j.1398-9995.57.s72.22.x  PMID:12144559
    • Lawson, B. R., Kono, D. H., Theofilopoulos, A. N. Deletion of p21 (WAF-1/Cip1) does not induce systemic autoimmunity in female BXSB mice Journal of Immunology  2002 168:5928-5932  PMID:12023399
    • Gorgani, N. N., Smith, B. A., Kono, D. H., Theofilopoulos, A. N. Histidine-rich glycoprotein binds to DNA and Fc gamma RI and potentiates the ingestion of apoptotic cells by macrophages Journal of Immunology  2002 169:4745-4751  PMID:12391183
    • Theofilopoulos, A. N., Kono, D. H. Genetics of systemic autoimmunity and glomerulonephritis in mouse models of lupus Nephrology Dialysis Transplantation  2001 16:65-67  PMID:11568247
    • Kono, D. H., Park, M. S., Szydlik, A., Haraldsson, K. M., Kuan, J. D., Pearson, D. L., Hultman, P., Pollard, K. M. Resistance to xenobiotic-induced autoimmunity maps to chromosome 1 Journal of Immunology  2001 167:2396-2403  PMID:11490030
    • Santiago-Raber, M. L., Lawson, B. R., Dummer, W., Barnhouse, M., Koundouris, S., Wilson, C. B., Kono, D. H., Theofilopoulos, A. N. Role of cyclin kinase inhibitor p21 in systemic autoimmunity Journal of Immunology  2001 167:4067-4074  PMID:11564828
    • Merriman, T. R., Cordell, H. J., Eaves, I. A., Danoy, P. A., Coraddu, F., Barber, R., Cucca, F., Broadley, S., Sawcer, S., Comptson, A., Wordsworth, P., Shatford, J., et al. Suggestive evidence for association of human chromosome 18q12-q21 and its orthologue on rat and mouse chromosome 18 with several autoimmune diseases Diabetes  2001 50:184-194  DOI:10.2337/diabetes.50.1.184  PMID:11147786
    • Theofilopoulos, A. N., Dummer, W., Kono, D. H. T cell homeostasis and systemic autoimmunity Journal of Clinical Investigation  2001 108:335-340  DOI:10.1172/jci12173  PMID:11489923
    • Feeney, A. J., Lawson, B. R., Kono, D. H., Theofilopoulos, A. N. Terminal deoxynucleotidyl transferase deficiency decreases autoimmune disease in MRL-Fas(lpr) mice Journal of Immunology  2001 167:3486-3493  PMID:11544342
    • Lawson, B. R., Koundouris, S. I., Barnhouse, M., Dummer, W., Baccala, R., Kono, D. H., Theofilopoulos, A. N. The role of alpha beta(+) T cells and homeostatic T cell proliferation in Y-chromosome-associated murine lupus Journal of Immunology  2001 167:2354-2360  PMID:11490025
    • Pollard, K. M., Pearson, D. L., Hultman, P., Deane, T. N., Lindh, U., Kono, D. H. Xenobiotic acceleration of idiopathic systemic autoimmunity in lupus-prone BXSB mice Environmental Health Perspectives  2001 109:27-33  DOI:10.2307/3434917  PMID:11171521  PMCID:PMC1242047
    • Kono, D. H., Balomenos, D., Park, M. S., Theofilopoulos, A. N. Development of lupus in BXSB mice is independent of IL-4 Journal of Immunology  2000 164:38-42  PMID:10604990
    • Kono, D. H., Theofilopoulos, A. N. Genetic studies in systemic autoimmunity and aging Immunologic Research  2000 21:111-122  DOI:10.1385/ir:21:2-3:111  PMID:10852108
    • Lawson, B. R., Prud'homme, G. J., Chang, Y. G., Gardner, H. A., Kuan, J., Kono, D. H., Theofilopoulos, A. N. Treatment of murine lupus with cDNA encoding IFN-gamma R/Fc Journal of Clinical Investigation  2000 106:207-215  DOI:10.1172/jci10167  PMID:10903336
    • Pollard, K. M., Pearson, D. L., Hultman, P., Hildebrandt, B., Kono, D. H. Lupus-prone mice as models to study xenobiotic-induced acceleration of systemic autoimmunity Environmental Health Perspectives  1999 107:729-735  DOI:10.2307/3434334  PMID:10502538
    • Maloy, K. J., Burkhart, C., Freer, G., Rulicke, T., Pircher, H., Kono, D. H., Theofilopoulos, A. N., Ludewig, B., Hoffmann-Rohrer, U., Zinkernagel, R. M., Hengartner, H. Qualitative and quantitative requirements for CD4(+) T cell-mediated antiviral protection Journal of Immunology  1999 162:2867-2874  PMID:10072535
    • Theofilopoulos, A. N., Kono, D. H. The genes of systemic autoimmunity Proceedings of the Association of American Physicians  1999 111:228-240  DOI:10.1046/j.1525-1381.1999.99244.x  PMID:10354363
    • Vidal, S., Kono, D. H., Theofilopoulos, A. N. Loci predisposing to autoimmunity in MRL-Fas(lpr) and C57BL/6-Fas(lpr) mice Journal of Clinical Investigation  1998 101:696-702  DOI:10.1172/jci1817  PMID:9449705
    • Ishikawa, T., Kono, D., Chung, J., Fowler, P., Theofilopoulos, A., Kakumu, S., Chisari, F. V. Polyclonality and multispecificity of the CTL response to a single viral epitope Journal of Immunology  1998 161:5842-5850  PMID:9834062
    • Kuan, J., Kono, D. H. TGFBR1 maps to chromosome 4 Mammalian Genome  1998 9:95-96  DOI:10.1007/s003359900695  PMID:9434964
    • Kono, D. H., Balomenos, D., Pearson, D. L., Park, M. S., Hildebrandt, B., Hultman, P., Pollard, K. M. The prototypic Th2 autoimmunity induced by mercury is dependent on IFN-gamma and not Th1/Th2 imbalance Journal of Immunology  1998 161:234-240  PMID:9647229
    • Norris, K., Norris, F., Kono, D. H., Vestergaard, H., Pedersen, O., Theofilopoulos, A. N., Moller, N. P. H. Expression of protein-tyrosine phosphatases in the major insulin target tissues FEBS Letters  1997 415:243-248  DOI:10.1016/s0014-5793(97)01133-2  PMID:9357975
    • Sabzevari, H., Propp, S., Kono, D. H., Theofilopoulos, A. N. G1 arrest and high expression of cyclin kinase and apoptosis inhibitors in accumulated activated memory phenotype CD4(+) cells of older lupus mice European Journal of Immunology  1997 27:1901-1910  DOI:10.1002/eji.1830270813  PMID:9295025
    • Shao, H., Kono, D. H., Chen, L. Y., Rubin, E. M., Kaye, J. Induction of the early growth response (Egr) family of transcription factors during thymic selection Journal of Experimental Medicine  1997 185:731-744  DOI:10.1084/jem.185.4.731  PMID:9034151
    • Kono, D. H., Theofilopoulos, A. N. Genetic contributions to SLE Journal of Autoimmunity  1996 9:437-452  DOI:10.1006/jaut.1996.0061  PMID:8864819
    • Kono, D. H., Owens, D. G., Wechsler, A. R. Jak3 maps to chromosome 8 Mammalian Genome  1996 7:476-477  DOI:10.1007/s003359900145  PMID:8662243
    • Duncan, S. R., Valentine, V., Roglic, M., Elias, D. J., Pekny, K. W., Theodore, J., Kono, D. H., Theofilopoulos, A. N. T cell receptor biases and clonal proliferations among lung transplant recipients with obliterative bronchiolitis Journal of Clinical Investigation  1996 97:2642-2650  DOI:10.1172/jci118714  PMID:8647959
    • Manca, F., Fenoglio, D., Valle, M. T., Lipira, G., Kunkl, A., Balderas, R. S., Baccala, R. G., Kono, D. H., Ferraris, A., Saverino, D., Lancia, F., Lozzi, L., et al. Human T-helper cells specific for HIV reverse-transcriptase - possible role in intrastructural help for HIV envelope-specific antibodies European Journal of Immunology  1995 25:1217-1223  DOI:10.1002/eji.1830250513  PMID:7539750
    • Balomenos, D., Balderas, R. S., Mulvany, K. P., Kaye, J., Kono, D. H., Theofilopoulos, A. N. Incomplete T-cell receptor V-beta allelic exclusion and dual V-beta-expressing cells Journal of Immunology  1995 155:3308-3312  PMID:7561023
    • Prudhomme, G. J., Kono, D. H., Theofilopoulos, A. N. Quantitative polymerase chain-reaction analysis reveals marked overexpression of interleukin-1-beta, interleukin-10 and interferon-gamma messenger-RNA in the lymph-nodes of lupus-prone mice Molecular Immunology  1995 32:495-503  DOI:10.1016/0161-5890(95)00024-9  PMID:7783752
    • Theofilopoulos, A. N., Baccala, R., Gonzalez-Quintial, R., Kono, D. H., Balderas, R. S., Macphee, R., Duncan, S. R., Roglic, M. T-cell repertoires in health and disease Annals of the New York Academy of Sciences  1995 756:53-65  DOI:10.1111/j.1749-6632.1995.tb44481.x  PMID:7645874
    • Churchill, M. E. A., Stura, E. A., Pinilla, C., Appel, J. R., Houghten, R. A., Kono, D. H., Balderas, R. S., Fieser, G. G., Schulzegahmen, U., Wilson, I. A. Crystal-structure of a peptide complex of antiinfluenza peptide antibody-Fab-26/9 - comparison of 2 different antibodies bound to the same peptide antigen Journal of Molecular Biology  1994 241:534-556  DOI:10.1006/jmbi.1994.1530  PMID:7520084
    • Kono, D. H., Burlingame, R. W., Owens, D. G., Kuramochi, A., Balderas, R. S., Balomenos, D., Theofilopoulos, A. N. Lupus susceptibility loci in New-Zealand mice Proceedings of the National Academy of Sciences of the United States of America  1994 91:10168-10172  DOI:10.1073/pnas.91.21.10168  PMID:7937857
    • Smith, L. R., Kono, D. H., Asthana, D., Balderas, R. S., Lindstrom, J., Theofilopoulos, A. N., Fujii, Y. T-cell receptor V-beta-15 dominates the antiacetylcholine receptor response in Lewis rat T-cell lines Journal of Immunology  1994 152:2596-2600  PMID:8133067
    • Seki, S., Kono, D. H., Balderas, R. S., Theofilopoulos, A. N. V-beta repertoire of murine hepatic T-cells - implication for selection of double-negative alpha-beta(+) T-cells Journal of Immunology  1994 153:637-646  PMID:8021501
    • Baccala, R., Vandekerckhove, B. A. E., Jones, D., Kono, D. H., Roncarolo, M. G., Theofilopoulos, A. N. Bacterial superantigens mediate T-cell deletions in the mouse severe combined immunodeficiency human liver thymus model Journal of Experimental Medicine  1993 177:1481-1485  DOI:10.1084/jem.177.5.1481  PMID:8478618
    • Cole, B. C., Balderas, R. A., Ahmed, E. A., Kono, D., Theofilopoulos, A. N. Genomic composition and allelic polymorphisms influence-V-beta usage by the mycoplasma-arthritidis superantigen Journal of Immunology  1993 150:3291-3299  PMID:8468471
    • Theofilopoulos, A. N., Balderas, R. S., Baccala, R., Kono, D. H. T-cell receptor genes in autoimmunity Annals of the New York Academy of Sciences  1993 681:33-46  DOI:10.1111/j.1749-6632.1993.tb22867.x  PMID:8357184
    • Kono, D. H., Baccala, R., Balderas, R. S., Kovac, S. J., Heald, P. W., Edelson, R. L., Theofilopoulos, A. N. Application of a multiprobe RNase protection assay and junctional sequences to define V beta gene diversity in Sezary-syndrome American Journal of Pathology  1992 140:823-830  PMID:1562047  PMCID:PMC1886373
    • Merrill, J. E., Kono, D. H., Clayton, J., Ando, D. G., Hinton, D. R., Hofman, F. M. Inflammatory leukocytes and cytokines in the peptide-induced disease of experimental allergic encephalomyelitis in SJL and B10.PL mice Proceedings of the National Academy of Sciences of the United States of America  1992 89:574-578  DOI:10.1073/pnas.89.2.574  PMID:1370583
    • Vandekerckhove, B. A. E., Baccala, R., Jones, D., Kono, D. H., Theofilopoulos, A. N., Roncarolo, M. G. Thymic selection of the human T-cell receptor V-beta repertoire in SCID-HU mice Journal of Experimental Medicine  1992 176:1619-1624  DOI:10.1084/jem.176.6.1619  PMID:1460421
    • Smith, L. R., Kono, D. H., Kammuller, M. E., Balderas, R. S., Theofilopoulos, A. N. V-beta repertoire in rats and implications for endogenous superantigens European Journal of Immunology  1992 22:641-645  DOI:10.1002/eji.1830220305  PMID:1312471
    • Smith, L. R., Kono, D. H., Theofilopoulos, A. N. Complexity and sequence identification of 24 rat V-beta genes Journal of Immunology  1991 147:375-379  PMID:1828824
    • Baccala, R., Kono, D. H., Walker, S., Balderas, R. S., Theofilopoulos, A. N. Genomically imposed and somatically modified human thymocyte V-beta gene repertoires Proceedings of the National Academy of Sciences of the United States of America  1991 88:2908-2912  DOI:10.1073/pnas.88.7.2908  PMID:2011599
    • Padula, S. J., Lingenheld, E. G., Stabach, P. R., Chou, C. H. J., Kono, D. H., Clark, R. B. Identification of encephalitogenic V-beta-4-bearing T-cells in SJL mice. Further evidence for the V-region disease hypothesis Journal of Immunology  1991 146:879-883  PMID:1703184
    • Plaza, A., Kono, D. H., Theofilopoulos, A. N. New human V-beta genes and polymorphic variants Journal of Immunology  1991 147:4360-4365  PMID:1684376
    • Hood, L., Kumar, V., Osman, G., Beall, S. S., Gomez, C., Funkhouser, W., Kono, D. H., Nickerson, D., Zaller, D. M., Urban, J. L. Autoimmune-disease and T-cell immunological recognition Cold Spring Harbor Symposia on Quantitative Biology  1989 54:859-874  PMID:2484250
    • Theofilopoulos, A. N., Singer, P. A., Kofler, R., Kono, D. H., Duchosal, M. A., Balderas, R. S. B-cell and T-cell antigen receptor repertoires in lupus arthritis murine models Springer Seminars in Immunopathology  1989 11:335-368  PMID:2694405
    • Ando, D. G., Clayton, J., Kono, D., Urban, J. L., Sercarz, E. E. Encephalitogenic T-cells in the B10.PL model of experimental allergic encephalomyelitis (EAE) are of the Th-1 lymphokine subtype Cellular Immunology  1989 124:132-143  DOI:10.1016/0008-8749(89)90117-2  PMID:2478300
    • Gross, U., Chen, J. H., Kono, D. H., Lobo, J. G., Yu, D. T. Y. High degree of conservation between ribosomal-proteins of Yersinia-pseudotuberculosis and Escherichia-coli Nucleic Acids Research  1989 17:3601-3602  DOI:10.1093/nar/17.9.3601  PMID:2657663
    • Clayton, J. P., Gammon, G. M., Ando, D. G., Kono, D. H., Hood, L., Sercarz, E. E. Peptide-specific prevention of experimental allergic encephalomyelitis - neonatal tolerance induced to the dominant T-cell determinant of myelin basic-protein Journal of Experimental Medicine  1989 169:1681-1691  DOI:10.1084/jem.169.5.1681  PMID:2469764
    • Urban, J. L., Kumar, V., Kono, D. H., Gomez, C., Horvath, S. J., Clayton, J., Ando, D. G., Sercarz, E. E., Hood, L. Restricted use of T-cell receptor V-genes in murine autoimmune encephalomyelitis raises possibilities for antibody therapy Cell  1988 54:577-592  DOI:10.1016/0092-8674(88)90079-7  PMID:2456857
    • Kono, D. H., Urban, J. L., Horvath, S. J., Ando, D. G., Saavedra, R. A., Hood, L. Two minor determinants of myelin basic protein induce experimental allergic encephalomyelitis in SJL/J mice Journal of Experimental Medicine  1988 168:213-227  DOI:10.1084/jem.168.1.213  PMID:2456367  PMCID:PMC2188984
    • Chen, J. H., Kono, D. H., Yong, Z., Park, M. S., Oldstone, Mmba, Yu, D. T. Y. A Yersinia-pseudotuberculosis protein which cross-reacts with HLA-B27 Journal of Immunology  1987 139:3003-3011  PMID:2444647
    • Ogasawara, M., Kono, D. H., Yu, D. T. Y. Mimicry of human histocompatibility HLA-B27 antigens by Klebsiella-pneumoniae Infection and Immunity  1986 51:901-908  PMID:3512439  PMCID:PMC260984
    • Ogasawara, M., Granfors, K., Kono, D. H., Hill, J. L., Yu, D. T. Y. A Yersinia-enterocolitica serotype 0-3 lipopolysaccharide-specific monoclonal-antibody reacts more strongly with bacteria cultured at room-temperature than those cultured at 37-degrees-C Journal of Immunology  1985 135:553-559  PMID:2582049
    • Ogasawara, M., Kobayashi, S., Arai, S., Laheji, K., Hill, J. L., Kono, D. H., Yu, D. T. Y. A heat-modifiable outer-membrane protein carries an antigen specific for the species Yersinia-enterocolitica and Yersinia-pseudotuberculosis Journal of Immunology  1985 135:1430-1436  PMID:2409152
    • Kono, D. H., Ogasawara, M., Yu, D. T. Y. An animal-model to study serum immunoglobulin response to infection by Yersinia-entercocolitica Clinical and Experimental Rheumatology  1985 3:117-121  PMID:4017307
    • Ogasawara, M., Kobayashi, S., Hill, J. L., Kono, D. H., Yu, D. T. Y. Rabbit antisera against 3 different bacteria which can induce reactive arthritis - analysis by ELISA, immunoprecipitation and western Blot Immunology  1985 54:665-676  PMID:3884493  PMCID:PMC1453566
    • Yu, D. T. Y., Ogasawara, M., Hill, J. L., Kono, D. H. Study of Reiters-syndrome, with special emphasis on Yersinia-enterocolitica Immunological Reviews  1985 86:27-45  DOI:10.1111/j.1600-065X.1985.tb01136.x  PMID:3876266
    • Kono, D. H., Ogasawara, M., Effros, R. B., Park, M. S., Waldord, R. L., Yu, D. T. Y. Ye-1, a monoclonal-antibody that cross-reacts with HLA-B27 lymphoblastoid cell-lines and an arthritis causing bacteria Clinical and Experimental Immunology  1985 61:503-508  PMID:3878239  PMCID:PMC1577260
    • Maeda, K., Kono, D., Kobayashi, S., Brenner, M. B., Yu, D. T. Y. A study of the specificity of the direct binding between bacteria and HLA antigens Clinical and Experimental Immunology  1984 57:694-702  PMID:6205801
    • Kono, D. H., Park, M. S., Yu, D. T. Y., Granfors, K., Toivanen, A. Absence of lymphotoxic antibodies in patients with Yersinia-induced arthritis, Reiter syndrome and ankylosing-spondylitis Clinical and Experimental Rheumatology  1984 2:303-307  PMID:6335862
    • Streicher, H. Z., Gabow, P. A., Moss, A. H., Kono, D., Kaehny, W. D. Syndromes of toluene sniffing in adults Annals of Internal Medicine  1981 94:758-762  DOI:10.7326/0003-4819-94-6-758  PMID:7235417
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Research

research overview

  • Our laboratory seeks to define the etiopathogenesis of systemic lupus erythematosus (SLE) and to identify potential therapeutic targets using lupus susceptible mice strains as model systems. Areas of interest related to lupus include systemic autoimmunity, tolerance, normal immune function, and genetics. A major focus is the identification of susceptibility genes in spontaneous lupus-prone mouse strains and in an induced model. Defining the genetic basis for lupus is critical for understanding lupus pathogenesis, as genetic susceptibility appears to be a prerequisite for disease development. Classical genetics approaches are being used to identify loci, narrow intervals with congenic mice, and identify genes. A second area of research seeks to identify the essential effector genes in SLE using both forward and reverse genetics approaches. These, in contrast to susceptibility genes, are normal genes that have non-redundant functions in disease pathogenesis. As such, their identification should yield important insights into disease processes and is also likely to have therapeutic implications. A third general area of interest is the study of specific pathways in lupus pathogenesis. Recent studies have investigated interferons, toll-like receptors, cell cycle control, and actin cytoskeleton regulation as they relate to systemic autoimmunity.
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Background

education and training

  • M.D. in Medicine 1977
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Contact

full name

  • Dwight H. Kono

geographic location

  • Scripps California 

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