Kishi, Shuji

Faculty Member

Positions

2009 - Adjunct Professor, Center for Biology & Biotechnology, Florida Atlantic University
2017 Associate Professor, Molecular Medicine , Scripps Research
2015 - 2017 Associate Professor, Metabolism and Aging , Scripps Research
2009 - 2017 Faculty Member, Skaggs Graduate School of Chemical and Biological Sciences , Scripps Research
2009 - 2015 Assistant Professor, Metabolism and Aging , Scripps Research

Dr. Shuji Kishi aims to develop a high-throughput processing system for gene identification and phenotype characterization particularly associated with age-related disorders in humans, using zebrafish as an amenable vertebrate model system.

Research Areas

Aging (UMLS)
Arthritis (UMLS)
Blindness (UMLS)

Publications
Research
Background
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recent publications

academic article
- Sasaki, T., Lian, S., Khan, A., Llop, J. R., Samuelson, A. V., Chen, W. B., Klionsky, D. J., Kishi, S. Autolysosome biogenesis and developmental senescence are regulated by both Spns1 and v-ATPase Autophagy 2017 13:386-403 DOI:10.1080/15548627.2016.1256934 PMID:27875093 PMCID:PMC5324850
- Song, Y., Zhou, H., Vo, M. N., Shi, Y., Nawaz, M. H., Vargas-Rodriguez, O., Diedrich, J. K., Yates III, J. R., Kishi, S., Musier-Forsyth, K., Schimmel, P. Double mimicry evades tRNA synthetase editing by toxic vegetable-sourced non-proteinogenic amino acid Nature Communications 2017 8 DOI:10.1038/s41467-017-02201-z PMID:29273753 PMCID:PMC5741666
- Song, Y., Shi, Y., Carland, T. M., Lian, S., Sasaki, T., Schork, N. J., Head, S. R., Kishi, S., Schimmel, P. p53-Dependent DNA damage response sensitive to editing-defective tRNA synthetase in zebrafish Proceedings of the National Academy of Sciences of the United States of America 2016 113:8460-8465 DOI:10.1073/pnas.1608139113 PMID:27402763 PMCID:PMC4968768
- Kishi, S., Bayliss, P. E., Hanai, J. I. A prospective epigenetic paradigm between cellular senescence and epithelial-mesenchymal transition in organismal development and aging Translational Research 2015 165:241-249 DOI:10.1016/j.trsl.2014.05.007 PMID:24924348
- Sasaki, T., Lian, S., Qi, J., Bayliss, P. E., Carr, C. E., Johnson, J. L., Guha, S., Kobler, P., Catz, S. D., Gill, M., Jia, K., Klionsky, D. J., et al. Aberrant autolysosomal regulation is linked to the induction of embryonic senescence: differential roles of Beclin 1 and p53 in vertebrate Spns1 deficiency PLoS Genetics 2014 10:e1004409 DOI:10.1371/journal.pgen.1004409 PMID:24967584 PMCID:PMC4072523
- Wei, N., Shi, Y., Truong, L. N., Fisch, K. M., Xu, T., Gardiner, E., Fu, G., Hsu, Y. S. O., Kishi, S., Su, A. I., Wu, X., Yang, X. L. Oxidative stress diverts tRNA synthetase to nucleus for protection against DNA damage Molecular Cell 2014 56:323-332 DOI:10.1016/j.molcel.2014.09.006 PMID:25284223 PMCID:PMC4224670
- Kishi, S. Using zebrafish models to explore genetic and epigenetic impacts on evolutionary developmental origins of aging Translational Research 2014 163:123-135 DOI:10.1016/j.trsl.2013.10.004 PMID:24239812 PMCID:PMC3969878
- Shi, Y., Xu, X., Zhang, Q., Fu, G., Mo, Z., Wang, G. S., Kishi, S., Yang, X. L. tRNA synthetase counteracts c-Myc to develop functional vasculature Elife 2014 3:e02349 DOI:10.7554/eLife.02349 PMID:24940000 PMCID:PMC4057782
- Sasaki, T., Kishi, S. Molecular and chemical genetic approaches to developmental origins of aging and disease in zebrafish Biochimica et Biophysica Acta 2013 1832:1362-1370 DOI:10.1016/j.bbadis.2013.04.030 PMID:23660559 PMCID:PMC3746063
- Sajish, M., Zhou, Q. S., Kishi, S., Valdez, D. M., Kapoor, M., Guo, M., Lee, S., Kim, S., Yang, X. L., Schimmel, P. Trp-tRNA synthetase bridges DNA-PKcs to PARP-1 to link IFN-γ and p53 signaling Nature Chemical Biology 2012 8:547-554 DOI:10.1038/nchembio.937 PMID:22504299 PMCID:PMC3780985
- Xu, X. L., Shi, Y., Zhang, H. M., Swindell, E. C., Marshall, A. G., Guo, M., Kishi, S., Yang, X. L. Unique domain appended to vertebrate tRNA synthetase is essential for vascular development Nature Communications 2012 3:681 DOI:10.1038/ncomms1686 PMID:22353712 PMCID:PMC3293412
- Koshimizu, E., Imamura, S., Qi, J., Toure, J., Valdez, D. M., Carr, C. E., Hanai, J., Kishi, S. Embryonic senescence and laminopathies in a progeroid zebrafish model PLoS One 2011 6:e17688 DOI:10.1371/journal.pone.0017688 PMID:21479207 PMCID:PMC3068137
- Kishi, S. The search for evolutionary developmental origins of aging in zebrafish: a novel intersection of developmental and senescence biology in the zebrafish model system Birth Defects Research Part C-Embryo Today-Reviews 2011 93:229-248 DOI:10.1002/bdrc.20217 PMID:21932432
- Kishi, S., Slack, B. E., Uchiyama, J., Zhdanova, I. V. Zebrafish as a genetic model in biological and behavioral gerontology: where development meets aging in vertebrates. A mini-review Gerontology 2009 55:430-441 DOI:10.1159/000228892 PMID:19654474 PMCID:PMC2820570
- Imamura, S., Uchiyama, J., Koshimizu, E., Hanai, J. I., Raftopoulou, C., Murphey, R. D., Bayliss, P. E., Imai, Y., Burns, C. E., Masutomi, K., Gagos, S., Zon, L. I., et al. A non-canonical function of zebrafish telomerase reverse transcriptase is required for developmental hematopoiesis PLoS One 2008 3:e3364 DOI:10.1371/journal.pone.0003364 PMID:18846223 PMCID:PMC2561060
- Zhdanova, I. V., Yu, L., Lopez-Patino, M., Shang, E., Kishi, S., Gueling, E. Aging of the circadian system in zebrafish and the effects of melatonin on sleep and cognitive performance Brain Research Bulletin 2008 75:433-441 DOI:10.1016/j.brainresbull.2007.10.053 PMID:18331912 PMCID:PMC2323434
- Sidi, S., Sanda, T., Kennedy, R. D., Hagen, A. T., Jette, C. A., Hoffmans, R., Pascual, J., Imamura, S., Kishi, S., Amatruda, J. F., Kanki, J. P., Green, D. R., et al. Chk1 suppresses a caspase-2 apoptotic response to DNA damage that bypasses p53, Bcl-2, and caspase-3 Cell 2008 133:864-877 DOI:10.1016/j.cell.2008.03.037 PMID:18510930 PMCID:PMC2719897
- Kishi, S., Bayliss, P. E., Uchiyama, J., Koshimizu, E., Qi, J., Nanjappa, P., Imamura, S., Islam, A., Neuberg, D., Amsterdam, A., Roberts, T. M. The identification of zebrafish mutants showing alterations in senescence-associated biomarkers PLoS Genetics 2008 4:e1000152 DOI:10.1371/journal.pgen.1000152 PMID:18704191 PMCID:PMC2515337
- Tsai, S. B., Tucci, V., Uchiyama, J., Fabian, N. J., Lin, M. C., Bayliss, P. E., Neuberg, D. S., Zhdanova, I. V., Kishi, S. Differential effects of genotoxic stress on both concurrent body growth and gradual senescence in the adult zebrafish Aging Cell 2007 6:209-224 DOI:10.1111/j.1474-9726.2007.00278.x PMID:17376146
- Hanai, J. I., Cao, P., Tanksale, P., Imamura, S., Koshimizu, E., Zhao, J. H., Kishi, S., Yamashita, M., Phillips, P. S., Sukhatme, V. P., Lecker, S. H. The muscle-specific ubiquitin ligase atrogin-1/MAFbx mediates statin-induced muscle toxicity Journal of Clinical Investigation 2007 117:3940-3951 DOI:10.1172/jci32741 PMID:17992259 PMCID:PMC2066198
- Yu, L. L., Tucci, V., Kishi, S., Zhdanova, I. V. Cognitive aging in zebrafish PLoS One 2006 1:e14 DOI:10.1371/journal.pone.0000014 PMID:17183640 PMCID:PMC1762370
- Imamura, S., Kishi, S. Molecular cloning and functional characterization of zebrafish ATM International Journal of Biochemistry & Cell Biology 2005 37:1105-1116 DOI:10.1016/j.biocel.2004.10.015 PMID:15743681
- Kishi, S. Functional aging and gradual senescence in zebrafish Annals of the New York Academy of Sciences 2004 1019:521-526 DOI:10.1196/annals.1297.097 PMID:15247079
- Kishi, S., Uchiyama, J., Baughman, A. M., Goto, T., Lin, M. C., Tsai, S. B. The zebrafish as a vertebrate model of functional aging and very gradual senescence Experimental Gerontology 2003 38:777-786 DOI:10.1016/s0531-5565(03)00108-6 PMID:12855287
- Kishi, S., Lu, K. P. A critical role for Pin2/TRF1 in ATM-dependent regulation. Inhibition of Pin2/TRF1 function complements telomere shortening, radiosensitivity, and the G(2)/M checkpoint defect of ataxia-telangiectasia cells Journal of Biological Chemistry 2002 277:7420-7429 DOI:10.1074/jbc.M111365200 PMID:11744712
- Nakamura, M., Zhou, X. Z., Kishi, S., Lu, K. P. Involvement of the telomeric protein Pin2/TRF1 in the regulation of the mitotic spindle FEBS Letters 2002 514:193-198 DOI:10.1016/s0014-5793(02)02363-3 PMID:11943150
- Nakamura, M., Zhou, X. Z., Kishi, S., Kosugi, I., Tsutsui, Y., Lu, K. P. A specific interaction between the telomeric protein Pin2/TRF1 and the mitotic spindle Current Biology 2001 11:1512-1516 DOI:10.1016/s0960-9822(01)00456-0 PMID:11591318
- Yabu, T., Kishi, S., Okazaki, T., Yamashita, M. Characterization of zebrafish caspase-3 and induction of apoptosis through ceramide generation in fish fathead minnow tailbud cells and zebrafish embryo Biochemical Journal 2001 360:39-47 DOI:10.1042/0264-6021:3600039 PMID:11695990 PMCID:PMC1222200
- Kishi, S., Zhou, X. Z., Ziv, Y., Khoo, C., Hill, D. E., Shiloh, Y., Lu, K. P. Telomeric protein Pin2/TRF1 as an important ATM target in response to double strand DNA breaks Journal of Biological Chemistry 2001 276:29282-29291 DOI:10.1074/jbc.M011534200 PMID:11375976
- Kishi, S., Wulf, G., Nakamura, M., Lu, K. P. Telomeric protein Pin2/TRF1 induces mitotic entry and apoptosis in cells with short telomeres and is down-regulated in human breast tumors Oncogene 2001 20:1497-1508 DOI:10.1038/sj.onc.1204229 PMID:11313893