recent publications
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academic article
- Nogal, B., Bianchi, M., Cottrell, C. A., Kirchdoerfer, R. N., Sewall, L. M., Turner, H. L., Zhao, F., Sok, D., Burton, D. R., Hangartner, L., Ward, A. B. Mapping polyclonal antibody responses in non-human primates vaccinated with HIV env trimer subunit vaccines Cell Reports 2020 30:3755-3765 DOI:10.1016/j.celrep.2020.02.061 PMID:32187547 PMCID:PMC7153566
- Wang, N., Rosen, O., Wang, L., Turner, H. L., Stevens, L. J., Corbett, K. S., Bowman, C. A., Pallesen, J., Shi, W., Zhang, Y., Leung, K., Kirchdoerfer, R. N., et al. Structural definition of a neutralization-sensitive epitope on the MERS-CoV S1-NTD Cell Reports 2019 28:3395-3405 DOI:10.1016/j.celrep.2019.08.052 PMID:31553909
- Kirchdoerfer, R. N., Ward, A. B. Structure of the SARS-CoV nsp12 polymerase bound to nsp7 and nsp8 co-factors Nature Communications 2019 10 DOI:10.1038/s41467-019-10280-3 PMID:31138817 PMCID:PMC6538669
- Kirchdoerfer, R. N., Saphire, E. O., Ward, A. B. Cryo-EM structure of the Ebola virus nucleoprotein-RNA complex Acta Crystallographica Section F-Structural Biology Communications 2019 75:340-347 DOI:10.1107/s2053230x19004424 PMID:31045563 PMCID:PMC6497097
- Kirchdoerfer, R. N., Wang, N., Pallesen, J., Wrapp, D., Turner, H. L., Cottrell, C. A., Corbett, K. S., Graham, B. S., McLellan, J. S., Ward, A. B. Stabilized coronavirus spikes are resistant to conformational changes induced by receptor recognition or proteolysis Scientific Reports 2018 8 DOI:10.1038/s41598-018-34171-7 PMID:30356097 PMCID:PMC6200764
- King, L. B., Fusco, M. L., Flyak, A. I., Ilinykh, P. A., Huang, K., Gunn, B., Kirchdoerfer, R. N., Hastie, K. M., Sangha, A. K., Meiler, J., Alter, G., Bukreyev, A., et al. The Marburgvirus-neutralizing human monoclonal antibody MR191 targets a conserved site to block virus receptor binding Cell Host & Microbe 2018 23:101-109 DOI:10.1016/j.chom.2017.12.003 PMID:29324225 PMCID:PMC5772738
- Pallesen, J., Wang, N., Corbett, K. S., Wrapp, D., Kirchdoerfer, R. N., Turner, H. L., Cottrell, C. A., Becker, M. M., Wang, L., Shi, W., Kong, W. P., Andres, E. L., et al. Immunogenicity and structures of a rationally designed prefusion MERS-CoV spike antigen Proceedings of the National Academy of Sciences of the United States of America 2017 114:E7348-E7357 DOI:10.1073/pnas.1707304114 PMID:28807998
- Bruhn, J. F., Kirchdoerfer, R. N., Urata, S. M., Li, S., Tickle, I. J., Bricogne, G., Saphire, E. O. Crystal structure of the Marburg virus VP35 oligomerization domain Journal of Virology 2017 91 DOI:10.1128/jvi.01085-16 PMID:27847355 PMCID:PMC5215338
- Kirchdoerfer, R. N., Wasserman, H., Amarasinghe, G. K., Saphire, E. O. Filovirus structural biology: the molecules in the machine Current Topics in Microbiology and Immunology 2017 411:381-417 DOI:10.1007/82_2017_16 PMID:28795188
- Kirchdoerfer, R. N., Moyer, C. L., Abelson, D. M., Saphire, E. O. The Ebola virus VP30-NP interaction Is a regulator of viral RNA synthesis PLoS Pathogens 2016 12 DOI:10.1371/journal.ppat.1005937 PMID:27755595 PMCID:PMC5068707
- Kirchdoerfer, R. N.*, Cottrell, C. A.*, Wang, N., Pallesen, J., Yassine, H. M., Turner, H. L., Corbett, K. S., Graham, B. S., McLellan, J. S., Ward, A. B. Pre-fusion structure of a human coronavirus spike protein Nature 2016 531:118-121 DOI:10.1038/nature17200 PMID:26935699 PMCID:PMC4860016 (* = equal contribution)
- Kirchdoerfer, R. N., Abelson, D. M., Li, S., Wood, M. R., Saphire, E. O. Assembly of the ebola virus nucleoprotein from a chaperoned VP35 complex Cell Reports 2015 12:140-149 DOI:10.1016/j.celrep.2015.06.003 PMID:26119732 PMCID:PMC4500542
- Clifton, M. C., Kirchdoerfer, R. N., Atkins, K., Abendroth, J., Raymond, A., Grice, R., Barnes, S., Moen, S., Lorimer, D., Edwards, T. E., Myler, P. J., Saphire, E. O. Structure of the Reston ebolavirus VP30 C-terminal domain Acta Crystallographica Section F-Structural Biology Communications 2014 70:457-460 DOI:10.1107/s2053230x14003811 PMID:24699737 PMCID:PMC3976061
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Lee, J. Y., Kim, H. S., Baek, I. W., Back, J. M., Han, M. R., Kong, S. Y., Kim, J. H., Kirchdoerfer, R. N., Kim, J. O., Cooper, M. D., Wilson, I. A., Kim, H. J., et al.
Overexpression, crystallization and preliminary x-ray crystallographic analysis of the variable lymphocyte receptor 2913 ectodomain fused with internalin b
Acta Crystallographica Section F-Structural Biology and Crystallization Communications
2013
69:39-41
DOI:10.1107/s1744309112045484
PMID:23295483
PMCID:PMC3539700
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Moeller, A., Kirchdoerfer, R. N., Potter, C. S., Carragher, B., Wilson, I. A.
Organization of the influenza virus replication machinery
Science
2012
338:1631-1634
DOI:10.1126/science.1227270
PMID:23180774
PMCID:PMC3578580
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Kirchdoerfer, R. N., Herrin, B. R., Han, B. W., Turnbough, C. L., Cooper, M. D., Wilson, I. A.
Variable lymphocyte receptor recognition of the immunodominant glycoprotein of bacillus anthracis spores
Structure
2012
20:479-486
DOI:10.1016/j.str.2012.01.009
PMID:22405006
PMCID:PMC3337218
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Kirchdoerfer, R. N., Garner, A. L., Flack, C. E., Mee, J. M., Horswill, A. R., Janda, K. D., Kaufmann, G. F., Wilson, I. A.
Structural basis for ligand recognition and discrimination of a quorum-quenching antibody
Journal of Biological Chemistry
2011
286:17351-17358
DOI:10.1074/jbc.M111.231258
PMID:21454495
PMCID:PMC3089576
- Ellis, J. P., Bakke, C. K., Kirchdoerfer, R. N., Jungbauer, L. M., Cavagnero, S. Chain dynamics of nascent polypeptides emerging from the ribosome ACS Chemical Biology 2008 3:555-566 DOI:10.1021/cb800059u PMID:18717565 PMCID:PMC2572860
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Debler, E. W., Kaufmann, G. F., Kirchdoerfer, R. N., Mee, J. M., Janda, K. D., Wilson, I. A.
Crystal structures of a quorum-quenching antibody
Journal of Molecular Biology
2007
368:1392-1402
DOI:10.1016/j.jmb.2007.02.081
PMID:17400249
PMCID:PMC1994716
- Kirchdoerfer, R. N., Huang, J. J. T., Isola, M. K., Cavagnero, S. Fluorescence-based analysis of aminoacyl- and peptidyl-tRNA by low-pH sodium dodecyl sulfate-polyacrylamide gel electrophoresis Analytical Biochemistry 2007 364:92-94 DOI:10.1016/j.ab.2007.01.019 PMID:17368419 PMCID:PMC2693959
