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Kirak, Oktay
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Kirak, Oktay

Faculty Member Adjunct
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Positions

  • 2017 - 2018 Assistant Professor Adjunct, Immunology and Microbiology , Scripps Research
  • 2016 - 2017 Assistant Professor Adjunct, Immunology and Microbial Science (IMS) , Scripps Research
  • 2011 - 2016 Assistant Professor, Immunology and Microbial Science (IMS) , Scripps Research
  • 2005 - 2010 Postdoctoral Associate, Whitehead Institute for Biomedical Research , Massachusetts Institute of Technology
The Kirak lab is interested in the long-standing question why our immune system attacks benign cells in autoimmune diseases, such as type-I diabetes, but fails to eliminate malignant cells in cancer. Dr. Kirak has pioneered Somatic Cell Nuclear Transfer (SCNT or NT, also known as "cloning") to develop and study novel mouse models of our immune system. Using these novel and more physiological NT models, the goal of the Kirak lab is to better understand this question, to identify novel mechanisms underlying autoimmune diseases and cancer, and to develop new therapeutics.

Research Areas research areas

  • Cancer (UMLS)
  • Nuclear Transfer (UMLS)
  • Somatic Cell (UMLS)
  • Somatic Cell Nuclear Transfer (aka Cloning)
  • autoimmune diabetes (UMLS)
  • stem cells (UMLS)
  • tumor immunology (UMLS)

Websites

  • Laboratory Website
  • LinkedIn
  • Twitter @Clone2Cure
  • Publications
  • Background
  • Contact
  • Identity
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Publications

recent publications

  • academic article

    • Ku, M., Chang, S. E., Hernandez, J., Abadejos, J. R., Sabouri-Ghomi, M., Muenchmeier, N. J., Schwarz, A., Valencia, A. M., Kirak, O. Nuclear transfer nTreg model reveals fate-determining TCR-β and novel peripheral nTreg precursors Proceedings of the National Academy of Sciences of the United States of America  2016  DOI:10.1073/pnas.1523664113  PMID:27044095  PMCID:PMC4843484
    • Ku, M., Chang, S. E., Hernandez, J., Abadejos, J. R., Sabouri-Ghomi, M., Muenchmeier, N. J., Schwarz, A., Valencia, A. M., Kirak, O. Nuclear transfer nTreg model reveals fate-determining TCR-β and novel peripheral nTreg precursors Proceedings of the National Academy of Sciences of the United States of America  2016 113:E2316-E2325  DOI:10.1073/pnas.1523664113  PMID:27044095  PMCID:PMC4843484
    • Kirak, O., Riethmuller, G. A novel, nonanaphylactogenic, bispecific IgE-CD3 antibody eliminates IgE1(+) B cells Journal of Allergy and Clinical Immunology  2015 136:800-802  DOI:10.1016/j.jaci.2015.02.017  PMID:25825213
    • Efeyan, A., Schweitzer, L. D., Bilate, A. M., Chang, S., Kirak, O., Lamming, D. W., Sabatini, D. M. RagA, but not RagB, is essential for embryonic development and adult mice Developmental Cell  2014 29:321-329  DOI:10.1016/j.devcel.2014.03.017  PMID:24768164  PMCID:PMC4035553
    • Sehrawat, S., Koenig, P. A., Kirak, O., Schlieker, C., Fankhauser, M., Ploegh, H. L. A catalytically inactive mutant of the deubiquitylase YOD-1 enhances antigen cross-presentation Blood  2013 121:1145-1156  DOI:10.1182/blood-2012-08-447409  PMID:23243279  PMCID:PMC3575758
    • Efeyan, A., Zoncu, R., Chang, S., Gumper, I., Snitkin, H., Wolfson, R. L., Kirak, O., Sabatini, D. D., Sabatini, D. M. Regulation of mTORC1 by the Rag GTPases is necessary for neonatal autophagy and survival Nature  2013 493:679-683  DOI:10.1038/nature11745  PMID:23263183  PMCID:PMC4000705
    • Avalos, A. M., Kirak, O., Oelkers, J. M., Pils, M. C., Kim, Y. M., Ottinger, M., Jaenisch, R., Ploegh, H. L., Brinkmann, M. M. Cell-specific TLR9 trafficking in primary APCs of transgenic TLR9-GFP mice Journal of Immunology  2013 190:695-702  DOI:10.4049/jimmunol.1202342  PMID:23241879  PMCID:PMC3539690
    • Sehrawat, S., Kirak, O., Koenig, P. A., Isaacson, M. K., Marques, S., Bozkurt, G., Simas, J. P., Jaenisch, R., Ploegh, H. L. CD8(+) T cells from mice transnuclear for a TCR that recognizes a single H-2K(b)-restricted MHV68 epitope derived from gB-ORF8 help control infection Cell Reports  2012 1:461-471  DOI:10.1016/j.celrep.2012.03.009  PMID:22832272  PMCID:PMC3406328
    • Medeiros, L. A., Dennis, L. M., Gill, M. E., Houbaviy, H., Markoulaki, S., Fu, D. D., White, A. C., Kirak, O., Sharp, P. A., Page, D. C., Jaenisch, R. Mir-290-295 deficiency in mice results in partially penetrant embryonic lethality and germ cell defects Proceedings of the National Academy of Sciences of the United States of America  2011 108:14163-14168  DOI:10.1073/pnas.1111241108  PMID:21844366  PMCID:PMC3161528
    • Kim, J., Lengner, C. J., Kirak, O., Hanna, J., Cassady, J. P., Lodato, M. A., Wu, S., Faddah, D. A., Steine, E. J., Gao, Q., Fu, D. D., Dawlaty, M., et al. Reprogramming of postnatal neurons into induced pluripotent stem cells by defined factors Stem Cells  2011 29:992-1000  DOI:10.1002/stem.641  PMID:21563275  PMCID:PMC3409465
    • Zheng, G. X. Y., Ravi, A., Calabrese, J. M., Medeiros, L. A., Kirak, O., Dennis, L. M., Jaenisch, R., Burge, C. B., Sharp, P. A. A latent pro-survival function for the mir-290-295 cluster in mouse embryonic stem cells PLoS Genetics  2011 7:e1002054  DOI:10.1371/journal.pgen.1002054  PMID:21573140  PMCID:PMC3088722
    • McGehee, A. M., Strijbis, K., Guillen, E., Eng, T., Kirak, O., Ploegh, H. L. Ubiquitin-dependent control of class II MHC localization is dispensable for antigen presentation and antibody production PLoS One  2011 6:e18817  DOI:10.1371/journal.pone.0018817  PMID:21533087  PMCID:PMC3080378
    • Schlegelmilch, K., Mohseni, M., Kirak, O., Pruszak, J., Rodriguez, J. R., Zhou, D. W., Kreger, B. T., Vasioukhin, V., Avruch, J., Brummelkamp, T. R., Camargo, F. D. Yap1 acts downstream of α-catenin to control epidermal proliferation Cell  2011 144:782-795  DOI:10.1016/j.cell.2011.02.031  PMID:21376238  PMCID:PMC3237196
    • Ernst, R., Claessen, J. H. L., Mueller, B., Sanyal, S., Spooner, E., van der Veen, A. G., Kirak, O., Schlieker, C. D., Weihofen, W. A., Ploegh, H. L. Enzymatic blockade of the ubiquitin-proteasome pathway PLoS Biology  2011 9:e1000605  DOI:10.1371/journal.pbio.1000605  PMID:21468303  PMCID:PMC3066133
    • Kirak, O., Frickel, E. M., Grotenbreg, G. M., Suh, H., Jaenisch, R., Ploegh, H. L. Transnuclear mice with pre-defined T cell receptor specificities against Toxoplasma gondii obtained via SCNT Journal of Visualized Experiments : JoVE  2010  DOI:10.3791/2168  PMID:20972401  PMCID:PMC3157875
    • Kirak, O., Frickel, E. M., Grotenbreg, G. M., Suh, H., Jaenisch, R., Ploegh, H. L. Transnuclear mice with predefined T cell receptor specificities against Toxoplasma gondii obtained via SCNT Science  2010 328:243-248  DOI:10.1126/science.1178590  PMID:20378817  PMCID:PMC2940321
    • Skelley, A. M., Kirak, O., Suh, H., Jaenisch, R., Voldman, J. Microfluidic control of cell pairing and fusion Nature Methods  2009 6:147-152  DOI:10.1038/nmeth.1290  PMID:19122668  PMCID:PMC3251011
    • Huynh, H. D., Iizuka, S., Kaba, M., Kirak, O., Zheng, J., Lodish, H. F., Zhang, C. C. Insulin-like growth factor-binding protein 2 secreted by a tumorigenic cell line supports ex vivo expansion of mouse hematopoietic stem cells Stem Cells  2008 26:1628-1635  DOI:10.1634/stemcells.2008-0064  PMID:18369099  PMCID:PMC2678056
    • Johnnidis, J. B., Harris, M. H., Wheeler, R. T., Stehling-Sun, S., Lam, M. H., Kirak, O., Brummelkamp, T. R., Fleming, M. D., Camargo, F. D. Regulation of progenitor cell proliferation and granulocyte function by microRNA-223 Nature  2008 451:1125-1129  DOI:10.1038/nature06607  PMID:18278031
    • Kim, K., Ng, K., Rugg-Gunn, P. J., Shieh, J. H., Kirak, O., Jaenisch, R., Wakayama, T., Moore, M. A., Pedersen, R. A., Daley, G. Q. Recombination signatures distinguish embryonic stem cells derived by parthenogenesis and somatic cell nuclear transfer Cell Stem Cell  2007 1:346-352  DOI:10.1016/j.stem.2007.07.001  PMID:18371368
  • thesis

    • Eliminierung IgE-positiver B-Lymphozyten mit Hilfe eines rekombinanten bispezifischen Anti-IgE-, Anti-CD3-Antikörpers [Elimination of IgE positive B cells using a recombinant bispecific anti-IgE, anti-CD3 antibody] 2010
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Background

education and training

  • Ph.D., Ludwig Maximilian University of Munich , Institute of Immunology 2010
  • M.D., Ludwig Maximilian University of Munich 1999 - 2003
  • Heidelberg University 1997 - 1999
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Contact

full name

  • Oktay Kirak

geographic location

  • Scripps California 
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Identity

ORCID iD

  • ORCID iD http://orcid.org/0000-0002-6524-4685

ResearcherID (Thomson Reuters)

  • H-6347-2013

Scopus ID

  • 20734685500

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