recent publications
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academic article
- Ku, M., Chang, S. E., Hernandez, J., Abadejos, J. R., Sabouri-Ghomi, M., Muenchmeier, N. J., Schwarz, A., Valencia, A. M., Kirak, O. Nuclear transfer nTreg model reveals fate-determining TCR-β and novel peripheral nTreg precursors Proceedings of the National Academy of Sciences of the United States of America 2016 DOI:10.1073/pnas.1523664113 PMID:27044095 PMCID:PMC4843484
- Ku, M., Chang, S. E., Hernandez, J., Abadejos, J. R., Sabouri-Ghomi, M., Muenchmeier, N. J., Schwarz, A., Valencia, A. M., Kirak, O. Nuclear transfer nTreg model reveals fate-determining TCR-β and novel peripheral nTreg precursors Proceedings of the National Academy of Sciences of the United States of America 2016 113:E2316-E2325 DOI:10.1073/pnas.1523664113 PMID:27044095 PMCID:PMC4843484
- Kirak, O., Riethmuller, G. A novel, nonanaphylactogenic, bispecific IgE-CD3 antibody eliminates IgE1(+) B cells Journal of Allergy and Clinical Immunology 2015 136:800-802 DOI:10.1016/j.jaci.2015.02.017 PMID:25825213
- Efeyan, A., Schweitzer, L. D., Bilate, A. M., Chang, S., Kirak, O., Lamming, D. W., Sabatini, D. M. RagA, but not RagB, is essential for embryonic development and adult mice Developmental Cell 2014 29:321-329 DOI:10.1016/j.devcel.2014.03.017 PMID:24768164 PMCID:PMC4035553
- Sehrawat, S., Koenig, P. A., Kirak, O., Schlieker, C., Fankhauser, M., Ploegh, H. L. A catalytically inactive mutant of the deubiquitylase YOD-1 enhances antigen cross-presentation Blood 2013 121:1145-1156 DOI:10.1182/blood-2012-08-447409 PMID:23243279 PMCID:PMC3575758
- Efeyan, A., Zoncu, R., Chang, S., Gumper, I., Snitkin, H., Wolfson, R. L., Kirak, O., Sabatini, D. D., Sabatini, D. M. Regulation of mTORC1 by the Rag GTPases is necessary for neonatal autophagy and survival Nature 2013 493:679-683 DOI:10.1038/nature11745 PMID:23263183 PMCID:PMC4000705
- Avalos, A. M., Kirak, O., Oelkers, J. M., Pils, M. C., Kim, Y. M., Ottinger, M., Jaenisch, R., Ploegh, H. L., Brinkmann, M. M. Cell-specific TLR9 trafficking in primary APCs of transgenic TLR9-GFP mice Journal of Immunology 2013 190:695-702 DOI:10.4049/jimmunol.1202342 PMID:23241879 PMCID:PMC3539690
- Sehrawat, S., Kirak, O., Koenig, P. A., Isaacson, M. K., Marques, S., Bozkurt, G., Simas, J. P., Jaenisch, R., Ploegh, H. L. CD8(+) T cells from mice transnuclear for a TCR that recognizes a single H-2K(b)-restricted MHV68 epitope derived from gB-ORF8 help control infection Cell Reports 2012 1:461-471 DOI:10.1016/j.celrep.2012.03.009 PMID:22832272 PMCID:PMC3406328
- Medeiros, L. A., Dennis, L. M., Gill, M. E., Houbaviy, H., Markoulaki, S., Fu, D. D., White, A. C., Kirak, O., Sharp, P. A., Page, D. C., Jaenisch, R. Mir-290-295 deficiency in mice results in partially penetrant embryonic lethality and germ cell defects Proceedings of the National Academy of Sciences of the United States of America 2011 108:14163-14168 DOI:10.1073/pnas.1111241108 PMID:21844366 PMCID:PMC3161528
- Kim, J., Lengner, C. J., Kirak, O., Hanna, J., Cassady, J. P., Lodato, M. A., Wu, S., Faddah, D. A., Steine, E. J., Gao, Q., Fu, D. D., Dawlaty, M., et al. Reprogramming of postnatal neurons into induced pluripotent stem cells by defined factors Stem Cells 2011 29:992-1000 DOI:10.1002/stem.641 PMID:21563275 PMCID:PMC3409465
- Zheng, G. X. Y., Ravi, A., Calabrese, J. M., Medeiros, L. A., Kirak, O., Dennis, L. M., Jaenisch, R., Burge, C. B., Sharp, P. A. A latent pro-survival function for the mir-290-295 cluster in mouse embryonic stem cells PLoS Genetics 2011 7:e1002054 DOI:10.1371/journal.pgen.1002054 PMID:21573140 PMCID:PMC3088722
- McGehee, A. M., Strijbis, K., Guillen, E., Eng, T., Kirak, O., Ploegh, H. L. Ubiquitin-dependent control of class II MHC localization is dispensable for antigen presentation and antibody production PLoS One 2011 6:e18817 DOI:10.1371/journal.pone.0018817 PMID:21533087 PMCID:PMC3080378
- Schlegelmilch, K., Mohseni, M., Kirak, O., Pruszak, J., Rodriguez, J. R., Zhou, D. W., Kreger, B. T., Vasioukhin, V., Avruch, J., Brummelkamp, T. R., Camargo, F. D. Yap1 acts downstream of α-catenin to control epidermal proliferation Cell 2011 144:782-795 DOI:10.1016/j.cell.2011.02.031 PMID:21376238 PMCID:PMC3237196
- Ernst, R., Claessen, J. H. L., Mueller, B., Sanyal, S., Spooner, E., van der Veen, A. G., Kirak, O., Schlieker, C. D., Weihofen, W. A., Ploegh, H. L. Enzymatic blockade of the ubiquitin-proteasome pathway PLoS Biology 2011 9:e1000605 DOI:10.1371/journal.pbio.1000605 PMID:21468303 PMCID:PMC3066133
- Kirak, O., Frickel, E. M., Grotenbreg, G. M., Suh, H., Jaenisch, R., Ploegh, H. L. Transnuclear mice with pre-defined T cell receptor specificities against Toxoplasma gondii obtained via SCNT Journal of Visualized Experiments : JoVE 2010 DOI:10.3791/2168 PMID:20972401 PMCID:PMC3157875
- Kirak, O., Frickel, E. M., Grotenbreg, G. M., Suh, H., Jaenisch, R., Ploegh, H. L. Transnuclear mice with predefined T cell receptor specificities against Toxoplasma gondii obtained via SCNT Science 2010 328:243-248 DOI:10.1126/science.1178590 PMID:20378817 PMCID:PMC2940321
- Skelley, A. M., Kirak, O., Suh, H., Jaenisch, R., Voldman, J. Microfluidic control of cell pairing and fusion Nature Methods 2009 6:147-152 DOI:10.1038/nmeth.1290 PMID:19122668 PMCID:PMC3251011
- Huynh, H. D., Iizuka, S., Kaba, M., Kirak, O., Zheng, J., Lodish, H. F., Zhang, C. C. Insulin-like growth factor-binding protein 2 secreted by a tumorigenic cell line supports ex vivo expansion of mouse hematopoietic stem cells Stem Cells 2008 26:1628-1635 DOI:10.1634/stemcells.2008-0064 PMID:18369099 PMCID:PMC2678056
- Johnnidis, J. B., Harris, M. H., Wheeler, R. T., Stehling-Sun, S., Lam, M. H., Kirak, O., Brummelkamp, T. R., Fleming, M. D., Camargo, F. D. Regulation of progenitor cell proliferation and granulocyte function by microRNA-223 Nature 2008 451:1125-1129 DOI:10.1038/nature06607 PMID:18278031
- Kim, K., Ng, K., Rugg-Gunn, P. J., Shieh, J. H., Kirak, O., Jaenisch, R., Wakayama, T., Moore, M. A., Pedersen, R. A., Daley, G. Q. Recombination signatures distinguish embryonic stem cells derived by parthenogenesis and somatic cell nuclear transfer Cell Stem Cell 2007 1:346-352 DOI:10.1016/j.stem.2007.07.001 PMID:18371368
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