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Janda, Kim
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Janda, Kim

Faculty Member
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Positions

  • 2017 - Professor (Joint Appointment), Immunology and Microbiology , Scripps Research
  • 1989 - Faculty Member, Skaggs Graduate School of Chemical and Biological Sciences , Scripps Research
  • 1985 - Professor, Chemistry , Scripps Research
  • Ely R. Callaway, Jr. Professor of Chemistry, Chemistry , Scripps Research
  • Member, The Skaggs Institute for Chemical Biology , Scripps Research
  • Director, The Worm Institute for Research and Medicine (WIRM) , Scripps Research
  • - 2017 Professor (Joint Appointment), Immunology and Microbial Science (IMS) , Scripps Research
Dr. Kim Janda is focused on the interfacing of chemistry and biology to discover molecules with function.

Research Areas research areas

  • Addiction (UMLS)
  • Blindness (UMLS)
  • Cancer (UMLS)
  • Diabetes (UMLS)

Contact

  • kdjanda@scripps.edu

Websites

  • Kim Janda, Ph.D.
  • Janda Laboratory
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Publications

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  • academic article

    • Belz, T. F., Bremer, P. T., Zhou, B., Blake, S., Ellis, B., Eubanks, L. M., Janda, K. D. Sulfonate-isosteric replacement examined within heroin-hapten vaccine design Bioorganic & Medicinal Chemistry Letters  2020 30  DOI:10.1016/j.bmcl.2020.127388  PMID:32738981  PMCID:PMC7398700
    • Belz, T. F., Bremer, P. T., Zhou, B., Ellis, B., Eubanks, L. M., Janda, K. D. Enhancement of a Heroin Vaccine through Hapten Deuteration Journal of the American Chemical Society  2020 142:13294-13298  DOI:10.1021/jacs.0c05219  PMID:32700530
    • Blake, S., Thanissery, R., Rivera, A. J., Hixon, M. S., Lin, M., Theriot, C. M., Janda, K. D. Salicylanilide Analog Minimizes Relapse of Clostridioides difficile Infection in Mice Journal of Medicinal Chemistry  2020 63:6898-6908  DOI:10.1021/acs.jmedchem.0c00123  PMID:32482070
    • Wang, J., Ellis, B., Zhou, B., Eubanks, L. M., Blake, S., Janda, K. D. A fentanyl vaccine constructed upon opsonizing antibodies specific for the Gal alpha 1-3Gal epitope Chemical Communications  2020 56:6551-6554  DOI:10.1039/d0cc02107e  PMID:32396160  PMCID:PMC7398699
    • Lee, J. C., Kim, H. Y., Lee, S. J., Shin, J., Kim, H. V., Kim, K., Baek, S., Lee, D. H., Jeon, H., Kim, D., Yang, S. H., Han, G. H., et al. Discovery of Chemicals to Either Clear or Indicate Amyloid Aggregates by Targeting Memory‐Impairing Anti‐Parallel Aβ Dimers Angewandte Chemie-International Edition  2020  DOI:10.1002/anie.202002574
    • Townsend, E. A., Bremer, P. T., Faunce, K. E., Negus, S. S., Aster, A. M., Robinson, H. L., Janda, K. D., Banks, M. L. Evaluation of a Dual Fentanyl/Heroin Vaccine on the Antinociceptive and Reinforcing Effects of a Fentanyl/Heroin Mixture in Male and Female Rats ACS Chemical Neuroscience  2020 11:1300-1310  DOI:10.1021/acschemneuro.0c00064  PMID:32271538
    • Lee, J. C., Kim, H. Y., Lee, S. J., Shin, J., Kim, H. V., Kim, K., Baek, S., Lee, D. H., Jeon, H., Kim, D., Yang, S. H., Han, G. H., et al. Discovery of Chemicals to Either Clear or Indicate Amyloid Aggregates by Targeting Memory-Impairing Anti-Parallel Aβ Dimers Angewandte Chemie-International Edition  2020 59:11491-11500  DOI:10.1002/ange.202002574  PMID:32233096
    • Tenney, R. D., Blake, S., Bremer, P. T., Zhou, B., Hwang, C. S., Poklis, J. L., Janda, K. D., Banks, M. L. Vaccine blunts fentanyl potency in male rhesus monkeys Neuropharmacology  2019 158  DOI:10.1016/j.neuropharm.2019.107730  PMID:31369740  PMCID:PMC6745253
    • Olson, M. E., Sugane, T., Zhou, B., Janda, K. D. Consequence of hapten stereochemistry: an efficacious methamphetamine vaccine Journal of the American Chemical Society  2019 141:14089-14092  DOI:10.1021/jacs.9b07294  PMID:31479256
    • Townsend, E. A., Blake, S., Faunce, K. E., Hwang, C. S., Natori, Y., Zhou, B., Bremer, P. T., Janda, K. D., Banks, M. L. Conjugate vaccine produces long-lasting attenuation of fentanyl vs. food choice and blocks expression of opioid withdrawal-induced increases in fentanyl choice in rats Neuropsychopharmacology  2019 44:1681-1689  DOI:10.1038/s41386-019-0385-9  PMID:31043682
    • Lin, L., Olson, M. E., Eubanks, L. M., Janda, K. D. Strategies to counteract botulinum neurotoxin A: nature's deadliest biomolecule Accounts of Chemical Research  2019 52:2322-2331  DOI:10.1021/acs.accounts.9b00261  PMID:31322847
    • Hwang, C. S., Smith, L. C., Wenthur, C. J., Ellis, B., Zhou, B., Janda, K. D. Heroin vaccine: Using titer, affinity, and antinociception as metrics when examining sex and strain differences Vaccine  2019 37:4155-4163  DOI:10.1016/j.vaccine.2019.05.061  PMID:31176539  PMCID:PMC6658211
    • Smith, L. C., Bremer, P. T., Hwang, C. S., Zhou, B., Ellis, B., Hixon, M. S., Janda, K. D. Monoclonal antibodies for combating synthetic opioid intoxication Journal of the American Chemical Society  2019 141:10489-10503  DOI:10.1021/jacs.9b04872  PMID:31187995
    • Nguyen, J. D., Grant, Y., Creehan, K. M., Hwang, C. S., Vandewater, S. A., Janda, K. D., Cole, M., Taffe, M. A. Δ9-tetrahydrocannabinol attenuates oxycodone self-administration under extended access conditions Neuropharmacology  2019 151:127-135  DOI:10.1016/j.neuropharm.2019.04.010  PMID:30980837  PMCID:PMC6510273
    • Natoriti, Y., Hwang, C. S., Lin, L., Smith, L. C., Zhou, B., Janda, K. D. A chemically contiguous hapten approach for a heroin-fentanyl vaccine Beilstein Journal of Organic Chemistry  2019 15:1020-1031  DOI:10.3762/bjoc.15.100
    • Wang, J., Merino, D. M., Light, N., Murphy, B. L., Wang, Y. D., Guo, X., Hodges, A. P., Chau, L. Q., Liu, K. W., Dhall, G., Asgharzadeh, S., Kiehna, E. N., et al. Mycand loss of p53 cooperate to drive formation of choroid plexus carcinoma Cancer Research  2019 79:2208-2219  DOI:10.1158/0008-5472.can-18-2565  PMID:30885981  PMCID:PMC6497574
    • Wenthur, C. J., Gautam, R., Zhou, B., Vendruscolo, L. F., Leggio, L., Janda, K. D. Ghrelin receptor influence on cocaine reward is not directly dependent on peripheral acyl-ghrelin Scientific Reports  2019 9  DOI:10.1038/s41598-019-38549-z  PMID:30755699  PMCID:PMC6372697
    • Olson, M. E., Eubanks, L. M., Janda, K. D. Chemical interventions for the opioid crisis: key advances and remaining challenges Journal of the American Chemical Society  2019 141:1798-1806  DOI:10.1021/jacs.8b09756  PMID:30532973
    • Hwang, C. S., Ellis, B., Zhou, B., Janda, K. D. Heat shock proteins: A dual carrier-adjuvant for an anti-drug vaccine against heroin Bioorganic & Medicinal Chemistry  2019 27:125-132  DOI:10.1016/j.bmc.2018.11.027  PMID:30497790
    • Smith, L. C., Lin, L., Hwang, C. S., Zhou, B., Kubitz, D. M., Wang, H., Janda, K. D. Lateral flow assessment and unanticipated toxicity of Kratom Chemical Research in Toxicology  2019 32:113-121  DOI:10.1021/acs.chemrestox.8b00218  PMID:30380840
    • Banks, M. L., Olson, M. E., Janda, K. D. Immunopharmacotherapies for treating opioid use disorder Trends in Pharmacological Sciences  2018 39:908-911  DOI:10.1016/j.tips.2018.08.001  PMID:30343725
    • Kallupi, M., Xue, S., Zhou, B., Janda, K. D., George, O. An enzymatic approach reverses nicotine dependence, decreases compulsive-like intake, and prevents relapse Science Advances  2018 4  DOI:10.1126/sciadv.aat4751  PMID:30345354  PMCID:PMC6192681
    • Shirey, R. J., Globisch, D., Eubanks, L. M., Hixon, M. S., Janda, K. D. Noninvasive urine biomarker lateral flow immunoassay for monitoring active onchocerciasis ACS Infectious Diseases  2018 4:1423-1431  DOI:10.1021/acsinfecdis.8b00163  PMID:30141624  PMCID:PMC6189908
    • Hwang, C. S., Smith, L. C., Natori, Y., Ellis, B., Zhou, B., Janda, K. D. Improved admixture vaccine of fentanyl and heroin hapten immunoconjugates: antinociceptive evaluation of fentanyl-contaminated heroin ACS Omega  2018 3:11537-11543  DOI:10.1021/acsomega.8b01478  PMID:30288464  PMCID:PMC6166218
    • Disney, M. D., Janda, K. D. Introduction Bioorganic & Medicinal Chemistry Letters  2018 28:2661-2662  DOI:10.1016/j.bmcl.2018.07.013  PMID:30029841
    • Kimishima, A., Olson, M. E., Janda, K. D. Investigations into the efficacy of multi-component cocaine vaccines Bioorganic & Medicinal Chemistry Letters  2018 28:2779-2783  DOI:10.1016/j.bmcl.2017.12.043  PMID:29317163  PMCID:PMC6013332
    • Jacob, N. T., Miranda, P. O., Shirey, R. J., Gautam, R., Zhou, B., Izquierdo, M. E. D., Hixon, M. S., Hart, J. R., Ueno, L., Vogt, P. K., Janda, K. D. Synthetic molecules for disruption of the MYC protein-protein interface Bioorganic & Medicinal Chemistry  2018 26:4234-4239  DOI:10.1016/j.bmc.2018.07.019  PMID:30037753
    • Nguyen, J. D., Hwang, C. S., Grant, Y., Janda, K. D., Taffe, M. A. Prophylactic vaccination protects against the development of oxycodone self-administration Neuropharmacology  2018 138:292-303  DOI:10.1016/j.neuropharm.2018.06.026  PMID:29936242
    • Tararina, M. A., Xue, S., Smith, L. C., Muellers, S. N., Miranda, P. O., Janda, K. D., Allen, K. N. Crystallography coupled with kinetic analysis provides mechanistic underpinnings of a nicotine-degrading enzyme Biochemistry  2018 57:3741-3751  DOI:10.1021/acs.biochem.8b00384  PMID:29812904
    • Hwang, C. S., Smith, L. C., Natori, Y., Ellis, B., Zhou, B., Janda, K. D. Efficacious vaccine against heroin contaminated with fentanyl ACS Chemical Neuroscience  2018 9:1269-1275  DOI:10.1021/acschemneuro.8b00079  PMID:29558798  PMCID:PMC6013375
    • Kimishima, A., Olson, M. E., Natori, Y., Janda, K. D. Efficient syntheses of cocaine vaccines and their in vivo evaluation ACS Medicinal Chemistry Letters  2018 9:411-416  DOI:10.1021/acsmedchemlett.8b00051  PMID:29795751  PMCID:PMC5949726
    • Miranda, P. O., Cubitt, B., Jacob, N. T., Janda, K. D., de la Torre, J. C. Mining a Kröhnke pyridine library for anti-arenavirus activity ACS Infectious Diseases  2018 4:815-824  DOI:10.1021/acsinfecdis.7b00236  PMID:29405696
    • Hwang, C. S., Bremer, P. T., Wenthur, C. J., Ho, S. O., Chiang, S., Ellis, B., Zhou, B., Fuji, G., Janda, K. D. Enhancing efficacy and stability of an antiheroin vaccine: examination of antinociception, opioid binding profile, and lethality Molecular Pharmaceutics  2018 15:1062-1072  DOI:10.1021/acs.molpharmaceut.7b00933  PMID:29420901
    • Xue, S., Kallupi, M., Zhou, B., Smith, L. C., Miranda, P. O., George, O., Janda, K. D. An enzymatic advance in nicotine cessation therapy Chemical Communications  2018 54:1686-1689  DOI:10.1039/c7cc09134f  PMID:29308799
    • Olson, M. E., Janda, K. D. Vaccines to combat the opioid crisis Vaccines that prevent opioids and other substances of abuse from entering the brain could effectively treat addiction and abuse EMBO Reports  2018 19:5-9  DOI:10.15252/embr.201745322  PMID:29237715  PMCID:PMC5757212
    • Xue, S., Seki, H., Remes, M., Silhar, P., Janda, K. Examination of α-exosite inhibitors against Botulinum neurotoxin A protease through structure-activity relationship studies of chicoric acid Bioorganic & Medicinal Chemistry Letters  2017 27:4956-4959  DOI:10.1016/j.bmcl.2017.10.021  PMID:29050781  PMCID:PMC5667901
    • Hwang, C. S., Janda, K. D. A vision for vaccines: combating the opioid epidemic Biochemistry  2017 56:5625-5627  DOI:10.1021/acs.biochem.7b00948  PMID:28994583
    • Wenthur, C. J., Zhou, B., Janda, K. D. Vaccine-driven pharmacodynamic dissection and mitigation of fenethylline psychoactivity Nature  2017 548:476-+  DOI:10.1038/nature23464  PMID:28813419
    • Wenthur, C. J., Cai, X., Ellis, B. A., Janda, K. D. Augmenting the efficacy of anti-cocaine catalytic antibodies through chimeric hapten design and combinatorial vaccination Bioorganic & Medicinal Chemistry Letters  2017 27:3666-3668  DOI:10.1016/j.bmcl.2017.07.014  PMID:28709828  PMCID:PMC5584565
    • Globisch, D., Eubanks, L. M., Shirey, R. J., Pfarr, K. M., Wanji, S., Debrah, A. Y., Hoerauf, A., Janda, K. D. Validation of onchocerciasis biomarker N-acetyltyramine-O-glucuronide (NATOG) Bioorganic & Medicinal Chemistry Letters  2017 27:3436-3440  DOI:10.1016/j.bmcl.2017.05.082  PMID:28600214  PMCID:PMC5510726
    • Jacob, N. T., Anraku, K., Kimishima, A., Zhou, B., Collins, K. C., Lockner, J. W., Ellis, B. A., Janda, K. D. A bioconjugate leveraging xenoreactive antibodies to alleviate cocaine-induced behavior Chemical Communications  2017 53:8156-8159  DOI:10.1039/c7cc04055e  PMID:28677711
    • Bremer, P. T., Janda, K. D. Conjugate vaccine immunotherapy for substance use disorder Pharmacological Reviews  2017 69:298-315  DOI:10.1124/pr.117.013904  PMID:28634286
    • Bremer, P. T., Schlosburg, J. E., Banks, M. L., Steele, F. F., Zhou, B., Poklis, J. L., Janda, K. D. Development of a clinically viable heroin vaccine Journal of the American Chemical Society  2017 139:8601-8611  DOI:10.1021/jacs.7b03334  PMID:28574716
    • Nguyen, J. D., Bremer, P. T., Hwang, C. S., Vandewater, S. A., Collins, K. C., Creehan, K. M., Janda, K. D., Taffe, M. A. Effective active vaccination against methamphetamine in female rats Drug and Alcohol Dependence  2017 175:179-186  DOI:10.1016/j.drugalcdep.2017.03.005  PMID:28437722
    • Bremer, P. T., Pellett, S., Carolan, J. P., Tepp, W. H., Eubanks, L. M., Allen, K. N., Johnson, E. A., Janda, K. D. Metal ions effectively ablate the action of Botulinum neurotoxin A Journal of the American Chemical Society  2017 139:7264-7272  DOI:10.1021/jacs.7b01084  PMID:28475321
    • Anraku, K., Sato, S., Jacob, N. T., Eubanks, L. M., Ellis, B. A., Janda, K. D. The design and synthesis of an α-Gal trisaccharide epitope that provides a highly specific anti-Gal immune response Organic & Biomolecular Chemistry  2017 15:2979-2992  DOI:10.1039/c7ob00448f  PMID:28294277
    • Srinivasulu, V., Janda, K. D., Abu-Yousef, I. A., O'Connor, M. J., Al-Tel, T. H. A modular CuI-L-proline catalyzed one-pot route for the rapid access of constrained and privileged hetero-atom-linked medium-sized ring systems Tetrahedron  2017 73:2139-2150  DOI:10.1016/j.tet.2017.02.061
    • Gooyit, M., Miranda, P. O., Wenthur, C. J., Ducime, A., Janda, K. D. Influencing antibody-mediated attenuation of methamphetamine CNS distribution through vaccine linker design ACS Chemical Neuroscience  2017 8:468-472  DOI:10.1021/acschemneuro.6b00389  PMID:27958709
    • Galinato, M. H., Lockner, J. W., Fannon-Pavlich, M. J., Sobieraj, J. C., Staples, M. C., Somkuwar, S. S., Ghofranian, A., Chaing, S., Navarro, A. I., Joea, A., Luikart, B. W., Janda, K. D., et al. A synthetic small-molecule Isoxazole-9 protects against methamphetamine relapse Molecular Psychiatry  2017 23:629-638  DOI:10.1038/mp.2017.46  PMID:28348387  PMCID:PMC5617764
    • Adler, M., Phung, C. H., Singh, A. K., Janda, K. D. Newly designed quinolinol inhibitors mitigate the effects of botulinum neurotoxin A in enzymatic, cell-based, and ex vivo assays Journal of Medicinal Chemistry  2017 60:338-348  DOI:10.1021/acs.jmedchem.6b01393  PMID:27966961
    • Kimishima, A., Wenthur, C. J., Zhou, B., Janda, K. D. An Advance in Prescription Opioid Vaccines: Overdose Mortality Reduction and Extraordinary Alteration of Drug Half-Life ACS Chemical Biology  2017 12:36-40  DOI:10.1021/acschembio.6b00977  PMID:28103678
    • Tararina, M. A., Janda, K. D., Allen, K. N. Structural analysis provides mechanistic insight into nicotine oxidoreductase from pseudomonas putida Biochemistry  2016 55:6595-6598  DOI:10.1021/acs.biochem.6b00963  PMID:27933790
    • Kimishima, A., Wenthur, C. J., Eubanks, L. M., Sato, S., Janda, K. D. Cocaine vaccine development: evaluation of carrier and adjuvant combinations that activate multiple toll-like receptors Molecular Pharmaceutics  2016 13:3884-3890  DOI:10.1021/acs.molpharmaceut.6b00682  PMID:27717287
    • Evans, S. M., Foltin, R. W., Hicks, M. J., Rosenberg, J. B., De, B. P., Janda, K. D., Kaminsky, S. M., Crystal, R. G. Efficacy of an adenovirus-based anti-cocaine vaccine to reduce cocaine self-administration and reacqusition using a choice procedure in rhesus macaques Pharmacology, Biochemistry and Behavior  2016 150:76-86  DOI:10.1016/j.pbb.2016.09.008  PMID:27697554  PMCID:PMC5145743
    • Zhou, B., Eubanks, L. M., Jacob, N. T., Ellis, B., Roberts, A. J., Janda, K. D. Studies towards the improvement of an anti-cocaine monoclonal antibody for treatment of acute overdose Bioorganic & Medicinal Chemistry Letters  2016 26:5078-5081  DOI:10.1016/j.bmcl.2016.08.081  PMID:27599743  PMCID:PMC5050165
    • Nguyen, J. D., Bremer, P. T., Ducime, A., Creehan, K. M., Kisby, B. R., Taffe, M. A., Janda, K. D. Active vaccination attenuates the psychostimulant effects of α-PVP and MDPV in rats Neuropharmacology  2016 116:1-8  DOI:10.1016/j.neuropharm.2016.12.005  PMID:27956054  PMCID:PMC5385148
    • Gooyit, M., Janda, K. D. Reprofiled anthelmintics abate hypervirulent stationary-phase Clostridium difficile Scientific Reports  2016 6  DOI:10.1038/srep33642  PMID:27633064  PMCID:PMC5025651
    • Gooyit, M. D., Janda, K. D. Modulation of the surface-layer protein of clostridium difficile through Cwp84 inhibition ACS Infectious Diseases  2016 2:465-470  DOI:10.1021/acsinfecdis.6b00061  PMID:27626098
    • Collins, K. C., Tsuchikama, K., Lowery, C. A., Zhu, J., Janda, K. D. Dissecting AI-2-mediated quorum sensing through C5-analogue synthesis and biochemical analysis Tetrahedron  2016 72:3593-3598  DOI:10.1016/j.tet.2015.08.063  PMID:27340303  PMCID:PMC4915392
    • Seki, H., Xue, S., Pellet, S., Silhar, P., Johnson, E. A., Janda, K. D. Cellular protection of SNAP-25 against botulinum neurotoxin/A: inhibition of thioredoxin reductase through a suicide substrate mechanism Journal of the American Chemical Society  2016 138:5568-5575  DOI:10.1021/jacs.5b12929  PMID:27070533  PMCID:PMC4881748
    • Collins, K. C., Schlosburg, J. E., Bremer, P. T., Janda, K. D. Methamphetamine vaccines: improvement through hapten design Journal of Medicinal Chemistry  2016 59:3878-3885  DOI:10.1021/acs.jmedchem.6b00084  PMID:27054372
    • Taffe, M. A., Nguyen, J. D., Bremer, P. T., Vandewater, S. A., Creehan, K. M., Janda, K. D. Active anti-methamphetamine vaccination attenuates the effects of methamphetamine The FASEB Journal  2016 30
    • Jacob, N. T., Lockner, J. W., Schlosburg, J. E., Ellis, B. A., Eubanks, L. M., Janda, K. D. Investigations of enantiopure nicotine haptens using an adjuvanting carrier in anti-nicotine vaccine development Journal of Medicinal Chemistry  2016 59:2523-2529  DOI:10.1021/acs.jmedchem.5b01676  PMID:26918428
    • Tsuchikama, K., Gooyit, M., Harris, T. L., Zhu, J., Globisch, D., Kaufmann, G. F., Janda, K. D. Glycation reactivity of a quorum-sensing signaling molecule Angewandte Chemie-International Edition  2016 55:4002-4006  DOI:10.1002/anie.201511911  PMID:26890076  PMCID:PMC4965832
    • Bremer, P. T., Kimishima, A., Schlosburg, J. E., Zhou, B., Collins, K. C., Janda, K. D. Combatting synthetic designer opioids: a conjugate vaccine ablates lethal doses of fentanyl class drugs Angewandte Chemie-International Edition  2016 55:3772-3775  DOI:10.1002/anie.201511654  PMID:26879590  PMCID:PMC4860013
    • Hart, J. R., Weinberg, M. S., Morris, K. V., Roberts, T. C., Janda, K. D., Garner, A. L., Vogt, P. K. MINCR is not a MYC-induced lncRNA Proceedings of the National Academy of Sciences of the United States of America  2016 113:E496-E497  DOI:10.1073/pnas.1519903113  PMID:26811502  PMCID:PMC4747730
    • Harris, T. L., Wenthur, C. J., Diego-Taboada, A., Mackenzie, G., Corbitt, T. S., Janda, K. D. Lycopodium clavatum exine microcapsules enable safe oral delivery of 3,4-diaminopyridine for treatment of botulinum neurotoxin A intoxication Chemical Communications  2016 52:4187-4190  DOI:10.1039/c6cc00615a  PMID:26906286
    • Bremer, P. T., Xue, S., Janda, K. D. Picolinic acids as β-exosite inhibitors of botulinum neurotoxin A light chain Chemical Communications  2016 52:12521-12524  DOI:10.1039/c6cc06749b  PMID:27722252  PMCID:PMC5085802
    • Globisch, D., Specht, S., Pfarr, K. M., Eubanks, L. M., Hoerauf, A., Janda, K. D. Litomosoides sigmodontis: A jird urine metabolome study Bioorganic & Medicinal Chemistry Letters  2015 25:5804-5807  DOI:10.1016/j.bmcl.2015.10.037  PMID:26573416
    • Miller, M. L., Aarde, S. M., Moreno, A. Y., Creehan, K. M., Janda, K. D., Taffe, M. A. Effects of active anti-methamphetamine vaccination on intravenous self-administration in rats Drug and Alcohol Dependence  2015 153:29-36  DOI:10.1016/j.drugalcdep.2015.06.014  PMID:26118833  PMCID:PMC4509945
    • Gooyit, M., Harris, T. L., Tricoche, N., Javor, S., Lustigman, S., Janda, K. D. Onchocerca volvulus molting inhibitors identified through scaffold hopping ACS Infectious Diseases  2015 1:198-202  DOI:10.1021/acsinfecdis.5b00017  PMID:27622649
    • Zhu, J., Cai, X., Harris, T. L., Gooyit, M., Wood, M., Lardy, M., Janda, K. D. Disarming Pseudomonas aeruginosa virulence factor LasB by leveraging a Caenorhabditis elegans infection model Chemistry & Biology  2015 22:483-491  DOI:10.1016/j.chembiol.2015.03.012  PMID:25892201
    • Gooyit, M., Tricoche, N., Javor, S., Lustigman, S., Janda, K. D. Exploiting the polypharmacology of ß-carbolines to disrupt O. volvulus molting ACS Medicinal Chemistry Letters  2015 6:339-343  DOI:10.1021/ml500516r  PMID:25815157  PMCID:PMC4360149
    • Lockner, J. W., Eubanks, L. M., Choi, J. L., Lively, J. M., Schlosburg, J. E., Collins, K. C., Globisch, D., Rosenfeld-Gunn, R. J., Wilson, I. A., Janda, K. D. Flagellin as carrier and adjuvant in cocaine vaccine development Molecular Pharmaceutics  2015 12:653-662  DOI:10.1021/mp500520r  PMID:25531528  PMCID:PMC4319694
    • Lockner, J. W., Lively, J. M., Collins, K. C., Vendruscolo, J. C. M., Azar, M. R., Janda, K. D. A conjugate vaccine using enantiopure hapten imparts superior nicotine-binding capacity Journal of Medicinal Chemistry  2015 58:1005-1011  DOI:10.1021/jm501625j  PMID:25493909
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    • Sue, S., Schlosburg, J. E., Janda, K. D. A new strategy for smoking cessation: characterization of a bacterial enzyme for the degradation of nicotine Journal of the American Chemical Society  2015 137:10136-10139  DOI:10.1021/jacs.5b06605  PMID:26237398
    • Pippione, A. C., Dosio, F., Ducime, A., Federico, A., Martina, K., Sainas, S., Frolund, B., Gooyit, M., Janda, K. D., Boschi, D., Lolli, M. L. Substituted 4-hydroxy-1,2,3-triazoles: synthesis, characterization and first drug design applications through bioisosteric modulation and scaffold hopping approaches MedChemComm  2015 6:1285-1292  DOI:10.1039/c5md00182j
    • Seki, H., Xue, S., Hixon, M. S., Pellett, S., Remes, M., Johnson, E. A., Janda, K. D. Toward the discovery of dual inhibitors for botulinum neurotoxin A: concomitant targeting of endocytosis and light chain protease activity Chemical Communications  2015 51:6226-6229  DOI:10.1039/c5cc00677e  PMID:25759983
    • Xue, S., Javor, S., Hixon, M. S., Janda, K. D. Probing BoNT/A protease exosites: implications for inhibitor design and light chain longevity Biochemistry  2014 53:6820-6824  DOI:10.1021/bi500950x  PMID:25295706  PMCID:PMC4222541
    • Raffeiner, P., Rock, R., Schraffl, A., Hartl, M., Hart, J. R., Janda, K. D., Vogt, P. K., Stefan, E., Bister, K. In vivo quantification and perturbation of Myc-Max interactions and the impact on oncogenic potential Oncotarget  2014 5:8869-8878  DOI:10.18632/oncotarget.2588  PMID:25326649  PMCID:PMC4253403
    • Eubanks, L. M., Ellis, B. A., Cai, X., Schlosburg, J. E., Janda, K. D. A human recombinant monoclonal antibody to cocaine: preparation, characterization and behavioral studies Bioorganic & Medicinal Chemistry Letters  2014 24:4664-4666  DOI:10.1016/j.bmcl.2014.08.035  PMID:25205191  PMCID:PMC4185020
    • Hart, J. R., Garner, A. L., Yu, J., Ito, Y., Sun, M. H., Ueno, L., Rhee, J. K., Baksh, M. M., Stefan, E., Hartl, M., Bister, K., Vogt, P. K., et al. Inhibitor of MYC identified in a Krohnke pyridine library Proceedings of the National Academy of Sciences of the United States of America  2014 111:12556-12561  DOI:10.1073/pnas.1319488111  PMID:25114221  PMCID:PMC4151726
    • Harris, T. L., Lowery, C. A., Hixon, M. S., Janda, K. D. A platform stratifying a sequestering agent and a pharmacological antagonist as a means to negate botulinum neurotoxicity ACS Chemical Neuroscience  2014 5:632-636  DOI:10.1021/cn500135h  PMID:25000171  PMCID:PMC4140587
    • Bremer, P. T., Hixon, M. S., Janda, K. D. Benzoquinones as inhibitors of botulinum neurotoxin serotype A Bioorganic & Medicinal Chemistry  2014 22:3971-3981  DOI:10.1016/j.bmc.2014.06.004  PMID:24984937  PMCID:PMC4138410
    • Gooyit, M., Tricoche, N., Lustigman, S., Janda, K. D. Dual protonophore-chitinase inhibitors dramatically affect O. volvulus molting Journal of Medicinal Chemistry  2014 57:5792-5799  DOI:10.1021/jm5006435  PMID:24918716  PMCID:PMC4216208
    • Jacob, N. T., Lockner, J. W., Kravchenko, V. V., Janda, K. D. Pharmacophore reassignment for induction of the immunosurveillance cytokine TRAIL Angewandte Chemie-International Edition  2014 53:6628-6631  DOI:10.1002/anie.201402133  PMID:24838721
    • Hicks, M. J., Kaminsky, S. M., De, B. P., Rosenberg, J. B., Evans, S. M., Foltin, R. W., Andrenyak, D. M., Moody, D. E., Koob, G. F., Janda, K. D., Arbona, R. J. R., Lepherd, M. L., et al. Fate of systemically administered cocaine in nonhuman primates treated with the dAd5GNE anticocaine vaccine Human Gene Therapy Clinical Development  2014 25:40-49  DOI:10.1089/humc.2013.231  PMID:24649839  PMCID:PMC4047994
    • Bremer, P. T., Schlosburg, J. E., Lively, J. M., Janda, K. D. Injection route and TLR9 agonist addition significantly impact heroin vaccine efficacy Molecular Pharmaceutics  2014 11:1075-1080  DOI:10.1021/mp400631w  PMID:24517171  PMCID:PMC3993894
    • Collins, K. C., Janda, K. D. Investigating hapten clustering as a strategy to enhance vaccines against drugs of abuse Bioconjugate Chemistry  2014 25:593-600  DOI:10.1021/bc500016k  PMID:24521489  PMCID:PMC3983143
    • Seki, H., Pellett, S., Silhar, P., Stowe, G. N., Blanco, B., Lardy, M. A., Johnson, E. A., Janda, K. D. Synthesis/biological evaluation of hydroxamic acids and their prodrugs as inhibitors for Botulinum neurotoxin A light chain Bioorganic & Medicinal Chemistry  2014 22:1208-1217  DOI:10.1016/j.bmc.2013.11.053  PMID:24360826  PMCID:PMC3919520
    • Collins, K. C., Schlosburg, J. E., Lockner, J. W., Bremer, P. T., Ellis, B. A., Janda, K. D. Lipid tucaresol as an adjuvant for methamphetamine vaccine development Chemical Communications  2014 50:4079-4081  DOI:10.1039/c4cc00682h  PMID:24615284  PMCID:PMC4033696
    • Lowery, C. A., Adler, M., Borrell, A., Janda, K. D. Scorpion toxins for the reversal of BoNT-induced paralysis Bioorganic & Medicinal Chemistry Letters  2013 23:6743-6746  DOI:10.1016/j.bmcl.2013.10.029  PMID:24252544  PMCID:PMC3869784
    • Cai, X., Whitfield, T., Moreno, A. Y., Grant, Y., Hixon, M. S., Koob, G. F., Janda, K. D. Probing the effects of hapten stability on cocaine vaccine immunogenicity Molecular Pharmaceutics  2013 10:4176-4184  DOI:10.1021/mp400214w  PMID:23927436  PMCID:PMC3946501
    • Silhar, P., Eubanks, L. M., Seki, H., Pellet, S., Javor, S., Tepp, W. H., Johnson, E. A., Janda, K. D. Targeting botulinum A cellular toxicity: a prodrug approach Journal of Medicinal Chemistry  2013 56:7870-7879  DOI:10.1021/jm400873n  PMID:24127873  PMCID:PMC3880648
    • Maoz, A., Hicks, M. J., Vallabhjosula, S., Synan, M., Kothari, P. J., Dyke, J. P., Ballon, D. J., Kaminsky, S. M., De, B. P., Rosenberg, J. B., Martinez, D., Koob, G. F., et al. Adenovirus capsid-based anti-cocaine vaccine prevents cocaine from binding to the nonhuman primate CNS dopamine transporter Neuropsychopharmacology  2013 38:2170-2178  DOI:10.1038/npp.2013.114  PMID:23660705  PMCID:PMC3773666
    • Lowery, C. A., Matamouros, S., Niessen, S., Zhu, J., Scolnick, J., Lively, J. M., Cravatt, B. F., Miller, S. I., Kaufmann, G. F., Janda, K. D. A chemical biology approach to interrogate quorum-sensing regulated behaviors at the molecular and cellular level Chemistry & Biology  2013 20:903-911  DOI:10.1016/j.chembiol.2013.05.009  PMID:23890008  PMCID:PMC3736722
    • Garner, A. L., Fullagar, J. L., Day, J. A., Cohen, S. M., Janda, K. D. Development of a high-throughput screen and its use in the discovery of Streptococcus pneumoniae immunoglobulin A1 protease inhibitors Journal of the American Chemical Society  2013 135:10014-10017  DOI:10.1021/ja404180x  PMID:23808771  PMCID:PMC3810181
    • Matyas, G. R., Mayorov, A. V., Rice, K. C., Jacobson, A. E., Cheng, K. J., Iyer, M. R., Li, F. Y., Janda, K. D., Alving, C. R., Beck, Z. Liposomes containing monophosphoryl lipid A: A potent adjuvant system for inducing antibodies to heroin hapten analogs Vaccine  2013 31:2804-2810  DOI:10.1016/j.vaccine.2013.04.027  PMID:23624097  PMCID:PMC4120113
    • Kravchenko, V., Garner, A. L., Mathison, J., Seit-Nebi, A., Yu, J., Gileva, I. P., Ulevitch, R., Janda, K. D. Facilitating cytokine-mediated cancer cell death by proteobacterial N-acylhomoserine lactones ACS Chemical Biology  2013 1117-1120  DOI:10.1021/cb4000184  PMID:23517377  PMCID:PMC3755046
    • Rosenberg, J. B., De, B. P., Hicks, M. J., Janda, K. D., Kaminsky, S. M., Worgall, S., Crystal, R. G. Suppression of nicotine-induced pathophysiology by an adenovirus hexon-based antinicotine vaccine Human Gene Therapy  2013 24:595-603  DOI:10.1089/hum.2012.245  PMID:23611296  PMCID:PMC3689186
    • Zhu, J., Hixon, M. S., Globisch, D., Kaufmann, G. F., Janda, K. D. Mechanistic insights into the LsrK kinase required for autoinducer-2 quorum sensing activation Journal of the American Chemical Society  2013 135:7827-7830  DOI:10.1021/ja4024989  PMID:23672516  PMCID:PMC3736694
    • Schlosburg, J. E., Vendruscolo, L. F., Bremer, P. T., Lockner, J. W., Wade, C. L., Nunes, A. A., Stowe, G. N., Edwards, S., Janda, K. D., Koob, G. F. Dynamic vaccine blocks relapse to compulsive intake of heroin Proceedings of the National Academy of Sciences of the United States of America  2013 110:9036-9041  DOI:10.1073/pnas.1219159110  PMID:23650354  PMCID:PMC3670323
    • Cai, X., Whitfield, T., Hixon, M. S., Grant, Y., Koob, G. F., Janda, K. D. Probing active cocaine vaccination performance through catalytic and noncatalytic hapten design Journal of Medicinal Chemistry  2013 56:3701-3709  DOI:10.1021/jm400228w  PMID:23627877  PMCID:PMC3691275
    • Miller, M. L., Moreno, A. Y., Aarde, S. M., Creehan, K. M., Vandewater, S. A., Vaillancourt, B. D., Wright, M. J., Jr., Janda, K. D., Taffe, M. A. A methamphetamine vaccine attenuates methamphetamine-induced disruptions in thermoregulation and activity in rats Biological Psychiatry  2013 73:721-8  DOI:10.1016/j.biopsych.2012.09.010  PMID:23098894  PMCID:PMC3561477
    • Struss, A. K., Nunes, A., Waalen, J., Lowery, C. A., Pullanikat, P., Denery, J. R., Conrad, D. J., Kaufmann, G. F., Janda, K. D. Toward implementation of quorum sensing autoinducers as biomarkers for infectious disease states Analytical Chemistry  2013 85:3355-62  DOI:10.1021/ac400032a  PMID:23391272  PMCID:PMC3604138
    • Globisch, D., Moreno, A. Y., Hixon, M. S., Nunes, A. A., Denery, J. R., Specht, S., Hoerauf, A., Janda, K. D. Onchocerca volvulus-neurotransmitter tyramine is a biomarker for river blindness Proceedings of the National Academy of Sciences of the United States of America  2013 110:4218-4223  DOI:10.1073/pnas.1221969110  PMID:23440222  PMCID:PMC3600455
    • Silhar, P., Silvaggi, N. R., Pellett, S., Capkova, K., Johnson, E. A., Allen, K. N., Janda, K. D. Evaluation of adamantane hydroxamates as botulinum neurotoxin inhibitors: Synthesis, crystallography, modeling, kinetic and cellular based studies Bioorganic & Medicinal Chemistry  2013 21:1344-1348  DOI:10.1016/j.bmc.2012.12.001  PMID:23340139  PMCID:PMC3574188
    • Cai, X. Q., Tsuchikama, K., Janda, K. D. Modulating cocaine vaccine potency through hapten fluorination Journal of the American Chemical Society  2013 135:2971-2974  DOI:10.1021/ja400356g  PMID:23398531  PMCID:PMC3637684
    • Lockner, J. W., Ho, S. O., McCague, K. C., Chiang, S. M., Do, T. Q., Fujii, G., Janda, K. D. Enhancing nicotine vaccine immunogenicity with liposomes Bioorganic & Medicinal Chemistry Letters  2013 23:975-978  DOI:10.1016/j.bmcl.2012.12.048  PMID:23313243  PMCID:PMC3557556
    • Silhar, P., Lardy, M. A., Hixon, M. S., Shoemaker, C. B., Barbieri, J. T., Struss, A. K., Lively, J. M., Javor, S., Janda, K. D. The C-terminus of botulinum A protease has profound and unanticipated kinetic consequences upon the catalytic cleft ACS Medicinal Chemistry Letters  2013 4:283-287  DOI:10.1021/ml300428s  PMID:23565325  PMCID:PMC3615567
    • Fullagar, J. L., Garner, A. L., Struss, A. K., Day, J. A., Martin, D. P., Yu, J., Cai, X., Janda, K. D., Cohen, S. M. Antagonism of a zinc metalloprotease using a unique metal-chelating scaffold: Tropolones as inhibitors of p. Aeruginosa elastase Chemical Communications  2013 49:3197-9  DOI:10.1039/c3cc41191e  PMID:23482955  PMCID:PMC3618488
    • De, B. P., Pagovich, O. E., Hicks, M. J., Rosenberg, J. B., Moreno, A. Y., Janda, K. D., Koob, G. F., Worgall, S., Kaminsky, S. M., Sondhi, D., Crystal, R. G. Disrupted adenovirus-based vaccines against small addictive molecules circumvent anti-adenovirus immunity Human Gene Therapy  2013 24:58-66  DOI:10.1089/hum.2012.163  PMID:23140508  PMCID:PMC3555097
    • Garner, A. L., Yu, J., Struss, A. K., Kaufmann, G. F., Kravchenko, V. V., Janda, K. D. Immunomodulation and the quorum sensing molecule 3-oxo-C-12-homoserine lactone: The importance of chemical scaffolding for probe development Chemical Communications  2013 49:1515-1517  DOI:10.1039/c3cc38851d  PMID:23328974  PMCID:PMC3566768
    • Bremer, P. T., Janda, K. D. Investigating the effects of a hydrolytically stable hapten and a Th1 adjuvant on heroin vaccine performance Journal of Medicinal Chemistry  2012 55:10776-10780  DOI:10.1021/jm301262z  PMID:23134263  PMCID:PMC3527012
    • von Hoven, G., Kloft, N., Neukirch, C., Ebinger, S., Bobkiewicz, W., Weis, S., Boller, K., Janda, K. D., Husmann, M. Modulation of translation and induction of autophagy by bacterial exoproducts Medical Microbiology and Immunology  2012 201:409-418  DOI:10.1007/s00430-012-0271-0  PMID:22991039  PMCID:PMC3470817
    • Moreno, A. Y., Azar, M. R., Koob, G. F., Janda, K. D. Probing the protective effects of a conformationally constrained nicotine vaccine Vaccine  2012 30:6665-6670  DOI:10.1016/j.vaccine.2012.08.064  PMID:22963803
    • Tsuchikama, K., Zhu, J., Lowery, C. A., Kaufmann, G. F., Janda, K. D. C4-alkoxy-hpd: A potent class of synthetic modulators surpassing nature in al-2 quorum sensing Journal of the American Chemical Society  2012 134:13562-13564  DOI:10.1021/ja305532y  PMID:22866957  PMCID:PMC3438919
    • Garner, A. L., Struss, A. K., Fullagar, J. L., Agrawal, A., Moreno, A. Y., Cohen, S. M., Janda, K. D. 3-hydroxy-1-alkyl-2-methylpyridine-4(1H)-thiones: inhibition of the Pseudomonas aeruginosa virulence factor LasB ACS Medicinal Chemistry Letters  2012 3:668-672  DOI:10.1021/ml300128f  PMID:23181168  PMCID:PMC3501683
    • Garner, A. L., Kim, S. K., Zhu, J., Struss, A. K., Watkins, R., Feske, B. D., Kaufmann, G. F., Janda, K. D. Stereochemical insignificance discovered in Acinetobacter baumannii quorum sensing PLoS One  2012 7:e37102  DOI:10.1371/journal.pone.0037102  PMID:22629354  PMCID:PMC3358330
    • Rosenberg, J. B., Hicks, M. J., De, B. P., Pagovich, O., Frenk, E., Janda, K. D., Wee, S., Koob, G. F., Hackett, N. R., Kaminsky, S. M., Worgall, S., Tignor, N., et al. AAVrh.10-mediated expression of an anti-cocaine antibody mediates persistent passive immunization that suppresses cocaine-induced behavior Human Gene Therapy  2012 23:451-459  DOI:10.1089/hum.2011.178  PMID:22486244  PMCID:PMC3360503
    • Treweek, J. B., Janda, K. D. An antidote for acute cocaine toxicity Molecular Pharmaceutics  2012 9:969-978  DOI:10.1021/mp200588v  PMID:22380623  PMCID:PMC3319285
    • Wee, S., Hicks, M. J., De, B. P., Rosenberg, J. B., Moreno, A. Y., Kaminsky, S. M., Janda, K. D., Crystal, R. G., Koob, G. F. Novel cocaine vaccine linked to a disrupted adenovirus gene transfer vector blocks cocaine psychostimulant and reinforcing effects Neuropsychopharmacology  2012 37:1083-1091  DOI:10.1038/npp.2011.200  PMID:21918504  PMCID:PMC3306868
    • Kravchenko, V. V., Gloeckner, C., Stowe, G. N., Kang, Y. J., Tobias, P. S., Mathison, J. C., Ulevitch, R. J., Kaufmann, G. F., Janda, K. D. The use of small molecule probes to study spatially separated stimulus-induced signaling pathways Bioorganic & Medicinal Chemistry Letters  2012 22:2043-2045  DOI:10.1016/j.bmcl.2012.01.024  PMID:22300658  PMCID:PMC3288742
    • Zakhari, J. S., Zorrilla, E. P., Zhou, B., Mayorov, A. V., Janda, K. D. Oligoclonal antibody targeting ghrelin increases energy expenditure and reduces food intake in fasted mice Molecular Pharmaceutics  2012 9:281-289  DOI:10.1021/mp200376c  PMID:22149064  PMCID:PMC3273630
    • Romano, A. A., Hahn, T., Davis, N., Lowery, C. A., Struss, A. K., Janda, K. D., Bottger, L. H., Matzanke, B. F., Carrano, C. J. The Fe(III) and Ga(III) coordination chemistry of 3-(1-hydroxymethylidene) and 3-(1-hydroxydecylidene)-5-(2-hydroxyethyl)pyrrolidine-2,4-dione: Novel tetramic acid degradation products of homoserine lactone bacterial quorum sensing molecules Journal of Inorganic Biochemistry  2012 107:96-103  DOI:10.1016/j.jinorgbio.2011.10.009  PMID:22178671  PMCID:PMC3258344
    • Globisch, D., Lowery, C. A., McCague, K. C., Janda, K. D. Uncharacterized 4,5-dihydroxy-2,3-pentanedione (DPD) molecules revealed through NMR spectroscopy: Implications for a greater signaling diversity in bacterial species Angewandte Chemie-International Edition  2012 51:4204-4208  DOI:10.1002/anie.201109149  PMID:22378693  PMCID:PMC3505754
    • Janda, K. D., Treweek, J. B. Vaccines targeting drugs of abuse: Is the glass half-empty or half-full? Nature Reviews Immunology  2012 12:67-72  DOI:10.1038/nri3130  PMID:22173478
    • Koob, G., Hicks, M. J., Wee, S., Rosenberg, J. B., De, B. P., Kaminksy, S. M., Moreno, A., Janda, K. D., Crystal, R. G. Anti-cocaine vaccine based on coupling a cocaine analog to a disrupted adenovirus CNS and Neurological Disorders-Drug Targets  2011 10:899-904  PMID:22229312  PMCID:PMC3369545
    • Hoon, S., Zhou, B., Janda, K. D., Brenner, S., Scolnick, J. Aptamer selection by high-throughput sequencing and informatic analysis Biotechniques  2011 51:413-416  DOI:10.2144/000113786  PMID:22150332
    • Moreno, A. Y., Janda, K. D. Current challenges for the creation of effective vaccines against drugs of abuse Expert Review of Vaccines  2011 10:1637-1639  DOI:10.1586/erv.11.145  PMID:22085165
    • Stowe, G. N., Schlosburg, J. E., Vendruscolo, L. F., Edwards, S., Misra, K. K., Schulteis, G., Zakhari, J. S., Koob, G. F., Janda, K. D. Developing a vaccine against multiple psychoactive targets: a case study of heroin CNS & Neurological Disorders-Drug Targets  2011 10:865-875  PMID:22229311  PMCID:PMC3327724
    • Zakhari, J. S., Kinoyama, I., Hixon, M. S., Di Mola, A., Globisch, D., Janda, K. D. Formulating a new basis for the treatment against botulinum neurotoxin intoxication: 3,4-Diaminopyridine prodrug design and characterization Bioorganic & Medicinal Chemistry  2011 19:6203-6209  DOI:10.1016/j.bmc.2011.09.019  PMID:21975066  PMCID:PMC3196298
    • Li, Z. R., Garner, A. L., Gloeckner, C., Janda, K. D., Carlow, C. K. Targeting the Wolbachia cell division protein FtsZ as a new approach for antifilarial therapy PLoS Neglected Tropical Diseases  2011 5:e1411  DOI:10.1371/journal.pntd.0001411  PMID:22140592  PMCID:PMC3226453
    • Liu, Y., Jiang, P. F., Capkova, K., Xue, D., Ye, L. W., Sinha, S. C., Mackman, N., Janda, K. D., Liu, C. Tissue factor-activated coagulation cascade in the tumor microenvironment is critical for tumor progression and an effective target for therapy Cancer Research  2011 71:6492-6502  DOI:10.1158/0008-5472.can-11-1145  PMID:21880589
    • Garner, A. L., Park, J., Zakhari, J. S., Lowery, C. A., Struss, A. K., Sawada, D., Kaufmann, G. F., Janda, K. D. A multivalent probe for AI-2 quorum-sensing receptors Journal of the American Chemical Society  2011 133:15934-15937  DOI:10.1021/ja207556d  PMID:21913711  PMCID:PMC3203215
    • Tsuchikama, K., Lowery, C. A., Janda, K. D. Probing autoinducer-2 based quorum sensing: The biological consequences of molecules unable to traverse equilibrium states Journal of Organic Chemistry  2011 76:6981-6989  DOI:10.1021/jo200882k  PMID:21678949  PMCID:PMC3162994
    • Stowe, G. N., Vendruscolo, L. F., Edwards, S., Schlosburg, J. E., Misra, K. K., Schulteis, G., Mayorov, A. V., Zakhari, J. S., Koob, G. F., Janda, K. D. A vaccine strategy that induces protective immunity against heroin Journal of Medicinal Chemistry  2011 54:5195-5204  DOI:10.1021/jm200461m  PMID:21692508  PMCID:PMC3142939
    • Garner, A. L., Goeckner, C., Tricoche, N., Zakhari, J. S., Samje, M., Cho-Ngwa, F., Lustigman, S., Janda, K. D. Design, synthesis, and biological activities of closantel analogues: structural promiscuity and its impact on Onchocerca volvulus Journal of Medicinal Chemistry  2011 54:3963-3972  DOI:10.1021/jm200364n  PMID:21534605
    • Uckun, F. M., Qazi, S., Ozer, Z., Garner, A. L., Pitt, J., Ma, H., Janda, K. D. Inducing apoptosis in chemotherapy-resistant B-lineage acute lymphoblastic leukaemia cells by targeting HSPA5, a master regulator of the anti-apoptotic unfolded protein response signalling network British Journal of Haematology  2011 153:741-752  DOI:10.1111/j.1365-2141.2011.08671.x  PMID:21517817
    • Kirchdoerfer, R. N., Garner, A. L., Flack, C. E., Mee, J. M., Horswill, A. R., Janda, K. D., Kaufmann, G. F., Wilson, I. A. Structural basis for ligand recognition and discrimination of a quorum-quenching antibody Journal of Biological Chemistry  2011 286:17351-17358  DOI:10.1074/jbc.M111.231258  PMID:21454495  PMCID:PMC3089576
    • Moreno, A. Y., Mayorov, A. V., Janda, K. D. Impact of distinct chemical structures for the development of a methamphetamine vaccine Journal of the American Chemical Society  2011 133:6587-6595  DOI:10.1021/ja108807j  PMID:21473576  PMCID:PMC3090292
    • Treweek, J. B., Roberts, A. J., Janda, K. D. Immunopharmacotherapeutic manifolds and modulation of cocaine overdose Pharmacology, Biochemistry and Behavior  2011 98:474-484  DOI:10.1016/j.pbb.2011.02.020  PMID:21356233  PMCID:PMC3069656
    • Garner, A. L., Yu, J., Struss, A. K., Lowery, C. A., Zhu, J., Kim, S. K., Park, J., Mayorov, A. V., Kaufmann, G. F., Kravchenko, V. V., Janda, K. D. Synthesis of 'clickable' acylhomoserine lactone quorum sensing probes: Unanticipated effects on mammalian cell activation Bioorganic & Medicinal Chemistry Letters  2011 21:2702-2705  DOI:10.1016/j.bmcl.2010.11.122  PMID:21190852  PMCID:PMC3081916
    • Stowe, G. N., Janda, K. D. A Diels-Alder reaction conducted within the parameters of aqueous organocatalysis: Still just smoke and mirrors Tetrahedron Letters  2011 52:2085-2087  DOI:10.1016/j.tetlet.2010.10.134  PMID:21516231  PMCID:PMC3079225
    • Silhar, P., Alakurtti, S., Caapkova, K., Feng, X. C., Shoemaker, C. B., Yli-Kauhaluoma, J., Janda, K. D. Synthesis and evaluation of library of betulin derivatives against the botulinum neurotoxin A protease Bioorganic & Medicinal Chemistry Letters  2011 21:2229-2231  DOI:10.1016/j.bmcl.2011.02.115  PMID:21421315  PMCID:PMC3070790
    • Zakhari, J. S., Kinoyama, I., Struss, A. K., Pullanikat, P., Lowery, C. A., Lardy, M., Janda, K. D. Synthesis and molecular modeling provide insight into a Pseudomonas aeruginosa quorum sensing conundrum Journal of the American Chemical Society  2011 133:3840-3842  DOI:10.1021/ja111138y  PMID:21348514  PMCID:PMC3060279
    • Hicks, M. J., De, B. P., Rosenberg, J. B., Davidson, J. T., Moreno, A. Y., Janda, K. D., Wee, S., Koob, G. F., Hackett, N. R., Kaminsky, S. M., Worgall, S., Toth, M., et al. Cocaine analog coupled to disrupted adenovirus: A vaccine strategy to evoke high-titer immunity against addictive drugs Molecular Therapy  2011 19:612-619  DOI:10.1038/mt.2010.280  PMID:21206484  PMCID:PMC3048190
    • Garner, A. L., Janda, K. D. Protein-protein interactions and cancer: targeting the central dogma Current Topics in Medicinal Chemistry  2011 11:258-280  DOI:10.2174/156802611794072614  PMID:21320057
    • Johnson, E. A., Lin, G. Y., Pier, C. L., Barbieri, J. T., Janda, K. D., Chen, C., Pellett, S., Tepp, W. H. Botulinum neurotoxin subtype A2 enters neuronal cells faster than subtype A1 FEBS Letters  2011 585:199-206  DOI:10.1016/j.febslet.2010.11.045  PMID:21126520  PMCID:PMC3041152
    • Salzameda, N. T., Eubanks, L. M., Zakhari, J. S., Tsuchikama, K., DeNunzio, N. J., Allen, K. N., Hixon, M. S., Janda, K. D. A cross-over inhibitor of the botulinum neurotoxin light chain B: A natural product implicating an exosite mechanism of action Chemical Communications  2011 47:1713-1715  DOI:10.1039/c0cc04078a  PMID:21203627  PMCID:PMC3065946
    • Garner, A. L., Janda, K. D. A small molecule antagonist of ghrelin O-acyltransferase (GOAT) Chemical Communications  2011 47:7512-7514  DOI:10.1039/c1cc11817j  PMID:21594284
    • Lowery, C. A., Kaufmann, G. F., Janda, K. D. Determination of acyl homoserine lactone and tetramic acid concentrations in biological samples Methods in Molecular Biology  2011 692:101-111  DOI:10.1007/978-1-60761-971-0_8  PMID:21031307
    • Kaufmann, G. F., Park, J., Mayorov, A. V., Kubitz, D. M., Janda, K. D. Generation of quorum quenching antibodies Methods in Molecular Biology  2011 692:299-311  DOI:10.1007/978-1-60761-971-0_22  PMID:21031321
    • Eubanks, L. M., Stowe, G. N., Marin, S. D., Mayorov, A. V., Hixon, M. S., Janda, K. D. Identification of alpha(2) macroglobulin as a major serum ghrelin esterase Angewandte Chemie-International Edition  2011 50:10699-10702  DOI:10.1002/anie.201104512  PMID:21928452  PMCID:PMC3515674
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    • Lowery, C. A., Salzameda, N. T., Sawada, D., Kaufmann, G. F., Janda, K. D. Medicinal chemistry as a conduit for the modulation of quorum sensing Journal of Medicinal Chemistry  2010 53:7467-7489  DOI:10.1021/jm901742c  PMID:20669927  PMCID:PMC2974035
    • Treweek, J. B., Roberts, A. J., Janda, K. D. Superadditive effects of ethanol and flunitrazepam: Implications of using immunopharmacotherapy as a therapeutic Molecular Pharmaceutics  2010 7:2056-2068  DOI:10.1021/mp900293a  PMID:20849117  PMCID:PMC2997924
    • Eubanks, L. M., Silhar, P., Salzameda, N. T., Zakhari, J. S., Xiaochuan, F., Barbieri, J. T., Shoemaker, C. B., Hixon, M. S., Janda, K. D. Identification of a natural product antagonist against the botulinum neurotoxin light chain protease ACS Medicinal Chemistry Letters  2010 1:268-272  DOI:10.1021/ml100074s  PMID:20959871  PMCID:PMC2955888
    • Thyagarajan, B., Potian, J. G., Garcia, C. C., Hognason, K., Capkova, K., Moe, S. T., Jacobson, A. R., Janda, K. D., McArdle, J. J. Effects of hydroxamate metalloendoprotease inhibitors on botulinum neurotoxin a poisoned mouse neuromuscular junctions Neuropharmacology  2010 58:1189-1198  DOI:10.1016/j.neuropharm.2010.02.014  PMID:20211192  PMCID:PMC2867082
    • Staflin, K., Krueger, J. S., Hachmann, J., Forsyth, J. S., Lorger, M., Steiniger, S. C. J., Mee, J., Pop, C., Salvesen, G. S., Janda, K. D., Felding-Habermann, B. Targeting activated integrin alpha v beta 3 with patient-derived antibodies impacts late-stage multiorgan metastasis Clinical & Experimental Metastasis  2010 27:217-231  DOI:10.1007/s10585-010-9320-5  PMID:20225083  PMCID:PMC4830478
    • Silhar, P., Capkova, K., Salzameda, N. T., Barbieri, J. T., Hixon, M. S., Janda, K. D. Botulinum neurotoxin a protease: Discovery of natural product exosite inhibitors Journal of the American Chemical Society  2010 132:2868-2869  DOI:10.1021/ja910761y  PMID:20158239  PMCID:PMC2832098
    • Moreno, A. Y., Azar, M. R., Warren, N. A., Dickerson, T. J., Koob, G. F., Janda, K. D. A critical evaluation of a nicotine vaccine within a self-administration behavioral model Molecular Pharmaceutics  2010 7:431-441  DOI:10.1021/mp900213u  PMID:20104903
    • Gloeckner, C., Garner, A. L., Mersha, F., Oksov, Y., Tricoche, N., Eubanks, L. M., Lustigman, S., Kaufmann, G. F., Janda, K. D. Repositioning of an existing drug for the neglected tropical disease Onchocerciasis Proceedings of the National Academy of Sciences of the United States of America  2010 107:3424-3429  DOI:10.1073/pnas.0915125107  PMID:20142509  PMCID:PMC2840490
    • Stowe, G. N., Silhar, P., Hixon, M. S., Silvaggi, N. R., Allen, K. N., Moe, S. T., Jacobson, A. R., Barbieri, J. T., Janda, K. D. Chirality holds the key for potent inhibition of the botulinum neurotoxin serotype A protease Organic Letters  2010 12:756-759  DOI:10.1021/ol902820z  PMID:20092262  PMCID:PMC2821465
    • Nakai, Y., Tepp, W. H., Janda, K. D., Johnson, E. A., Pellett, S. Toosendanin: Synthesis of the AB-ring and investigations of its anti-botulinum properties (part II) Bioorganic & Medicinal Chemistry  2010 18:1280-1287  DOI:10.1016/j.bmc.2009.12.030  PMID:20044261  PMCID:PMC2819598
    • Barbieri, J. T., Pellett, S., Capkova, K., Hixon, M. S., Janda, K. D., Johnson, E. A. Benzylidene cyclopentenediones: First irreversible inhibitors against botulinum neurotoxin A's zinc endopeptidase Bioorganic & Medicinal Chemistry Letters  2010 20:206-208  DOI:10.1016/j.bmcl.2009.10.129  PMID:19914829  PMCID:PMC2818383
    • Garner, A. L., Janda, K. D. Cat-ELCCA: A robust method to monitor the fattty acid acyltransferase activityy of Grehlin O-Acyltransferase (GOAT) Angewandte Chemie-International Edition  2010 49:9630-9634  DOI:10.1002/anie.201003387  PMID:20845345  PMCID:PMC3485397
    • Fukuchi, K., Steiniger, S. C. J., Deryugina, E., Liu, Y., Lowery, C. A., Gloeckner, C., Zhou, B., Kaufmann, G. F., Quigley, J. P., Janda, K. D. Inhibition of tumor metastasis: functional immune modulation of the CUB domain containing protein 1 Molecular Pharmaceutics  2010 7:245-253  DOI:10.1021/mp900236t  PMID:19916495  PMCID:PMC2815031
    • Denery, J. R., Nunes, A. A. K., Hixon, M. S., Dickerson, T. J., Janda, K. D. Metabolomics-based discovery of diagnostic biomarkers for onchocerciasis PLoS Neglected Tropical Diseases  2010 4:e834  DOI:10.1371/journal.pntd.0000834  PMID:20957145  PMCID:PMC2950146
    • Lowery, C. A., Abe, T., Park, J., Eubanks, L. M., Sawada, D., Kaufmann, G. F., Janda, K. D. Revisiting AI-2 quorum sensing inhibitors: Direct comparison of alkyl-DPD analogues and a natural product fimbrolide Journal of the American Chemical Society  2009 131:15584-15585  DOI:10.1021/ja9066783  PMID:19824634  PMCID:PMC2784249
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    • Lowery, C. A., Park, J., Gloeckner, C., Meijler, M. M., Mueller, R. S., Boshoff, H. I., Ulrich, R. L., Barry, C. E., Bartlett, D. H., Kravchenko, V. V., Kaufmann, G. F., Janda, K. D. Defining the mode of action of tetramic acid antibacterials derived from Pseudomonas aeruginosa quorum sensing signals Journal of the American Chemical Society  2009 131:14473-14479  DOI:10.1021/ja9056079  PMID:19807189  PMCID:PMC2760024
    • Capkova, K., Salzameda, N. T., Janda, K. D. Investigations into small molecule non-peptidic inhibitors of the botulinum neurotoxins Toxicon  2009 54:575-582  DOI:10.1016/j.toxicon.2009.03.016  PMID:19327377  PMCID:PMC2730986
    • Frederick, M. O., Marin, S. D., Janda, K. D., Nicolaou, K. C., Dickerson, T. J. Monoclonal antibodies with orthogonal azaspiracid epitopes ChemBioChem  2009 10:1625-1629  DOI:10.1002/cbic.200900201  PMID:19492388  PMCID:PMC2750835
    • Treweek, J. B., Dickerson, T. J., Janda, K. D. Drugs of abuse that mediate advanced glycation end product formation: A chemical link to disease pathology Accounts of Chemical Research  2009 42:659-669  DOI:10.1021/ar800247d  PMID:19275211  PMCID:PMC2982794
    • Sheng, J. W., Oyler, G., Zhou, B., Janda, K., Shoemaker, C. B. Identification and characterization of a novel cell-penetrating peptide Biochemical and Biophysical Research Communications  2009 382:236-240  DOI:10.1016/j.bbrc.2008.11.139  PMID:19084505  PMCID:PMC3006162
    • Moreno, A. Y., Janda, K. D. Immunopharmacotherapy: Vaccination strategies as a treatment for drug abuse and dependence Pharmacology, Biochemistry and Behavior  2009 92:199-205  DOI:10.1016/j.pbb.2009.01.015  PMID:19350728  PMCID:PMC2768391
    • Pires-Alves, M., Ho, M. F., Aberle, K. K., Janda, K. D., Wilson, B. A. Tandem fluorescent proteins as enhanced FRET-based substrates for botulinum neurotoxin activity Toxicon  2009 53:392-399  DOI:10.1016/j.toxicon.2008.12.016  PMID:19168088  PMCID:PMC2649687
    • Janda, K. D., Fischer, A., Tepp, W. H., Eubanks, L. M., Clancy, C. M., Montal, M., Pellett, S., Johnson, E. A., Dickerson, T. J., Nakai, Y. Bimodal modulation of the botulinum neurotoxin protein-conducting channel Proceedings of the National Academy of Sciences of the United States of America  2009 106:1330-1335  DOI:10.1073/pnas.0812839106  PMID:19164566  PMCID:PMC2635780
    • Dickerson, T. J., Janda, K. D., Tepp, W. H., Nakai, Y., Johnson, E. A. Function-oriented synthesis applied to the anti-botulinum natural product toosendanin Bioorganic & Medicinal Chemistry  2009 17:1152-1157  DOI:10.1016/j.bmc.2008.12.042  PMID:19131252  PMCID:PMC2661763
    • Janda, K. D., Zhou, H. Y., Johnson, E. A., Pellett, S., Zhou, B. Selection and characterization of a human monoclonal neutralizing antibody for clostridium Botulinum Neurotoxin serotype B Bioorganic & Medicinal Chemistry Letters  2009 19:662-664  DOI:10.1016/j.bmcl.2008.12.055  PMID:19112017  PMCID:PMC2645068
    • Treweek, J. B., Moreno, A. Y., Janda, K. D. SLEEPLESS-ness and insomnia in fruit flies Angewandte Chemie-International Edition  2009 48:438-440  DOI:10.1002/anie.200804552  PMID:19072956
    • Treweek, J. B., Sun, C., Mayorov, A. V., Qi, L., Levy, C. L., Roberts, A. J., Dickerson, T. J., Janda, K. D. Prevention of drug-induced memory impairment by immunopharmacotherapy Journal of Medicinal Chemistry  2008 51:6866-6875  DOI:10.1021/jm800506v  PMID:18921991  PMCID:PMC2661766
    • Mayorov, A. V., Amara, N., Chang, J. Y., Moss, J. A., Hixon, M. S., Ruiz, D. I., Meijler, M. M., Zorrilla, E. P., Janda, K. D. Catalytic antibody degradation of ghrelin increases whole-body metabolic rate and reduces refeeding in fasting mice Proceedings of the National Academy of Sciences of the United States of America  2008 105:17487-17492  DOI:10.1073/pnas.0711808105  PMID:18981425  PMCID:PMC2582297
    • Park, J., Dickerson, T. J., Janda, K. D. Major sperm protein as a diagnostic antigen for onchocerciasis Bioorganic & Medicinal Chemistry  2008 16:7206-7209  DOI:10.1016/j.bmc.2008.06.038  PMID:18632276
    • Lowery, C. A., Park, J., Kaufmann, G. F., Janda, K. D. An unexpected switch in the modulation of AI-2-based quorum sensing discovered through synthetic 4,5-dihydroxy-2,3-pentanedione analogues Journal of the American Chemical Society  2008 130:9200-9201  DOI:10.1021/ja802353j  PMID:18576653  PMCID:PMC2668569
    • Kravchenko, V. V., Kaufmann, G. F., Mathison, J. C., Scott, D. A., Katz, A. Z., Grauer, D. C., Lehmann, M., Meijler, M. M., Janda, K. D., Ulevitch, R. J. Modulation of gene expression via disruption of NF-kappa B signaling by a bacterial small molecule Science  2008 321:259-263  DOI:10.1126/science.1156499  PMID:18566250
    • Kaufmann, G. F., Park, J., Janda, K. D. Bacterial quorum sensing: A new target for anti-infective immunotherapy Expert Opinion on Biological Therapy  2008 8:719-724  DOI:10.1517/14712590802088006  PMID:18476783
    • Janda, K. Instant insight - communicating with nature Chemistry World  2008 5:35-35
    • Kaufmann, G. F., Park, J., Mee, J. M., Ulevitch, R. J., Janda, K. D. The quorum quenching antibody RS2-1G9 protects macrophages from the cytotoxic effects of the pseudomonas aeruginosa quorum sensing signalling molecule N-3-oxo-dodecanoyl-homoserine lactone Molecular Immunology  2008 45:2710-2714  DOI:10.1016/j.molimm.2008.01.010  PMID:18304641  PMCID:PMC2359578
    • Zhou, B., Pellett, S., Johnson, E. A., Janda, K. D., Tepp, W. H., Zhou, H. Delineating the susceptibility of botulinum neurotoxins to denaturation through thermal effects FEBS Letters  2008 582:1526-1531  DOI:10.1016/j.febslet.2008.03.047  PMID:18396167
    • Yoneda, Y., Steiniger, S. C. J., Capkova, K., Mee, J. M., Liu, Y., Kaufmann, G. F., Janda, K. D. A cell-penetrating peptidic GRP78 ligand for tumor cell-specific prodrug therapy Bioorganic & Medicinal Chemistry Letters  2008 18:1632-1636  DOI:10.1016/j.bmcl.2008.01.060  PMID:18243696  PMCID:PMC2288489
    • Debler, E. W., Kaufmann, G. F., Meijler, M. M., Heine, A., Mee, J. M., Pljevaljcic, G., Di Bilio, A. J., Schultz, P. G., Millar, D. P., Janda, K. D., Wilson, I. A., Gray, H. B., et al. Deeply inverted electron-hole recombination in a luminescent antibody-stilbene complex Science  2008 319:1232-1235  DOI:10.1126/science.1153445  PMID:18309081
    • Zhou, B., Carney, C., Janda, K. D. Selection and characterization of human antibodies neutralizing Bacillus anthracis toxin Bioorganic & Medicinal Chemistry  2008 16:1903-1913  DOI:10.1016/j.bmc.2007.11.001  PMID:18023190  PMCID:PMC2268906
    • Willis, B., Eubanks, L. M., Wood, M. R., Janda, K. D., Dickerson, T. J., Lerner, R. A. Biologically templated organic polymers with nanoscale order Proceedings of the National Academy of Sciences of the United States of America  2008 105:1416-1419  DOI:10.1073/pnas.0711308105  PMID:18216240  PMCID:PMC2234158
    • Zarebski, L. M., Vaughan, K., Sidney, J., Peters, B., Grey, H., Janda, K. D., Casadevall, A., Sette, A. Analysis of epitope information related to Bacillus anthracis and Clostridium botulinum Expert Review of Vaccines  2008 7:55-74  DOI:10.1586/14760584.7.1.55  PMID:18251694  PMCID:PMC3319117
    • Richardson, H. N., Zhao, Y., Fekete, E. M., Funk, C. K., Wirsching, P., Janda, K. D., Zorrilla, E. P., Koob, G. F. MPZP: A novel small molecule corticotropin-releasing factor type 1 receptor (CRF1) antagonist Pharmacology, Biochemistry and Behavior  2008 88:497-510  DOI:10.1016/j.pbb.2007.10.008  PMID:18031798  PMCID:PMC3319109
    • Lowery, C. A., Dickerson, T. J., Janda, K. D. Interspecies and interkingdom communication mediated by bacterial quorum sensing Chemical Society Reviews  2008 37:1337-1346  DOI:10.1039/b702781h  PMID:18568160
    • Steiniger, S. C. J., Coppinger, J. A., Kruger, J. A., Yates, J., Janda, K. D. Quantitative mass spectrometry identifies drug targets in cancer stem cell-containing side population Stem Cells  2008 26:3037-3046  DOI:10.1634/stemcells.2008-0397  PMID:18802034  PMCID:PMC2745975
    • Park, J., Kaufmann, G. F., Bowen, J. P., Arbiser, J. L., Janda, K. D. Solenopsin A, a venom alkaloid from the fire ant Solenopsis invicta, inhibits quorum-sensing signaling in Pseudomonas aeruginosa Journal of Infectious Diseases  2008 198:1198-1201  DOI:10.1086/591916  PMID:18713055
    • Willis, B., Eubanks, L. M., Dickerson, T. J., Janda, K. D. The strange case of the botulinum neurotoxin: Using chemistry and bilogy to modulate the most deadly poison Angewandte Chemie-International Edition  2008 47:8360-8379  DOI:10.1002/anie.200705531  PMID:18844202
    • Capkova, K., Hixon, M. S., McAllister, L. A., Janda, K. D. Toward the discovery of potent inhibitors of botulinum neurotoxin a: Development of a robust lc ms based assay operational from low to subnanomolar enzyme concentrations Chemical Communications  2008 3525-3527  DOI:10.1039/b808305c  PMID:18654701
    • Brogan, A. P., Dickerson, T. J., Janda, K. D. Noirnicotine-organocatalyzed aqueous reduction of alpha,beta-unsaturated aldehydes Chemical Communications  2007 4952-4954  DOI:10.1039/b713273e  PMID:18361380
    • Capkova, K., Yoneda, Y., Dickerson, T. J., Janda, K. D. Synthesis and structure-activity relationships of second-generation hydroxamate botulinum neurotoxin A protease inhibitors Bioorganic & Medicinal Chemistry Letters  2007 17:6463-6466  DOI:10.1016/j.bmcl.2007.09.103  PMID:17951059  PMCID:PMC2170532
    • Zhou, H. Y., Zhou, B., Ma, H. Z., Carney, C., Janda, K. D. Selection and characterization of human monoclonal antibodies against Abrin by phage display Bioorganic & Medicinal Chemistry Letters  2007 17:5690-5692  DOI:10.1016/j.bmcl.2007.07.053  PMID:17764932
    • Park, J., Jagasia, R., Kaufmann, G. F., Mathison, J. C., Ruiz, D. I., Moss, J. A., Meijler, M. M., Ulevitch, R. J., Janda, K. D. Infection control by antibody disruption of bacterial quorum sensing signaling Chemistry & Biology  2007 14:1119-1127  DOI:10.1016/j.chembiol.2007.08.013  PMID:17961824  PMCID:PMC2088803
    • Xu, Y., Hixon, M. S., Dawson, P. E., Janda, K. D. Development of a FRET assay for monitoring of HIV gp41 core disruption Journal of Organic Chemistry  2007 72:6700-6707  DOI:10.1021/jo070836l  PMID:17685571
    • Ino, A., Dickerson, T. J., Janda, K. D. Positional linker effects in haptens for cocaine immunopharmacotherapy Bioorganic & Medicinal Chemistry Letters  2007 17:4280-4283  DOI:10.1016/j.bmcl.2007.05.032  PMID:17531484
    • Dickerson, T. J., McKenzie, K. M., Hoyt, A. S., Wood, M. R., Janda, K. D., Brenner, S. B., Lerner, R. A. Phage escape libraries for checkmate analysis Proceedings of the National Academy of Sciences of the United States of America  2007 104:12703-12708  DOI:10.1073/pnas.0705362104  PMID:17646645  PMCID:PMC1937530
    • Treweek, J., Wee, S., Koob, G. F., Dickerson, T. J., Janda, K. D. Self-vaccination by methamphetamine glycation products chemically links chronic drug abuse and cardiovascular disease Proceedings of the National Academy of Sciences of the United States of America  2007 104:11580-11584  DOI:10.1073/pnas.0701328104  PMID:17592122  PMCID:PMC1913859
    • Debler, E. W., Kaufmann, G. F., Kirchdoerfer, R. N., Mee, J. M., Janda, K. D., Wilson, I. A. Crystal structures of a quorum-quenching antibody Journal of Molecular Biology  2007 368:1392-1402  DOI:10.1016/j.jmb.2007.02.081  PMID:17400249  PMCID:PMC1994716
    • Liu, Y., Steiniger, S. C. J., Kim, Y., Kaufmann, G. F., Felding-Habermann, B., Janda, K. D. Mechanistic studies of a peptidic GRP78 ligand for cancer cell-specific drug delivery Molecular Pharmaceutics  2007 4:435-447  DOI:10.1021/mp060122j  PMID:17373820  PMCID:PMC2533281
    • Silvaggi, N. R., Boldt, G. E., Hixon, M. S., Kennedy, J. P., Tzipori, S., Janda, K. D., Allen, K. N. Structures of clostridium botulinum neurotoxin serotype A light chain complexed with small-molecule inhibitors highlight active-site flexibility Chemistry & Biology  2007 14:533-542  DOI:10.1016/j.chembiol.2007.03.014  PMID:17524984
    • Steiniger, S. C. J., Altobell, L. J., Zhou, B., Janda, K. D. Selection of human antibodies against cell surface-associated oligomeric anthrax protective antigen Molecular Immunology  2007 44:2749-2755  DOI:10.1016/j.molimm.2006.11.011  PMID:17210180
    • Brogan, A. P., Eubanks, L. M., Koob, G. F., Dickerson, T. J., Janda, K. D. Antibody-catalyzed oxidation of delta(9)-tetrahydrocannabinol Journal of the American Chemical Society  2007 129:3698-3702  DOI:10.1021/ja070022m  PMID:17335216
    • Marin, S. D., Xu, Y., Meijler, M. M., Janda, K. D. Antibody catalyzed hydrolysis of a quorum sensing signal found in gram-negative bacteria Bioorganic & Medicinal Chemistry Letters  2007 17:1549-1552  DOI:10.1016/j.bmcl.2006.12.118  PMID:17254784
    • Xu, Y., Hixon, M. S., Yamamoto, N., McAllister, L. A., Wentworth, A. D., Wentworth, P., Janda, K. D. Antibody-catalyzed anaerobic destruction of methamphetamine Proceedings of the National Academy of Sciences of the United States of America  2007 104:3681-3686  DOI:10.1073/pnas.0611094104  PMID:17360412  PMCID:PMC1820643
    • McAllister, L. A., Hixon, M. S., Schwartz, R., Kubitz, D. S., Janda, K. D. Synthesis and application of a novel ligand for affinity chromatography based removal of endotoxin from antibodies Bioconjugate Chemistry  2007 18:559-566  DOI:10.1021/bc0602984  PMID:17315943
    • McKenzie, K. M., Mee, J. M., Rogers, C. J., Hixon, M. S., Kaufmann, G. F., Janda, K. D. Identification and characterization of single chain anti-cocaine catalytic antibodies Journal of Molecular Biology  2007 365:722-731  DOI:10.1016/j.jmb.2006.10.031  PMID:17084858  PMCID:PMC1828637
    • Dickerson, T. J., Clancy, C. M., Johnson, E. A., Baldwin, M. R., Jin, W., Barbieri, J. T., Tepp, W. H., Eubanks, L. M., Malizio, C. J., Goodnough, M. C., Janda, K. D., Hong, S., et al. An in vitro and in vivo disconnect uncovered through high-throughput identification of botulinum neurotoxin A antagonists Proceedings of the National Academy of Sciences of the United States of America  2007 104:2602-2607  DOI:10.1073/pnas.0611213104  PMID:17293454  PMCID:PMC1815229
    • Eubanks, L. M., Dickerson, T. J., Janda, K. D. Technological advancements for the detection of and protection against biological and chemical warfare agents Chemical Society Reviews  2007 36:458-470  DOI:10.1039/b615227a  PMID:17325785
    • Rogers, C. J., Eubanks, L. M., Dickerson, T. J., Janda, K. D. Unexpected acetylcholinesterase activity of cocaine esterases Journal of the American Chemical Society  2006 128:15364-15365  DOI:10.1021/ja066241+  PMID:17131989  PMCID:PMC2533137
    • Eubanks, L. M., Rogers, C. J., Beuscher, A. E., Koob, G. F., Olson, A. J., Dickerson, T. J., Janda, K. D. A molecular link between the active component of marijuana and Alzheimer's disease pathology Molecular Pharmaceutics  2006 3:773-777  DOI:10.1021/mp060066m  PMID:17140265  PMCID:PMC2562334
    • Kravchenko, V. V., Kaufmann, G. F., Mathison, J. C., Scott, D. A., Katz, A. Z., Wood, M. R., Brogan, A. P., Lehmann, M., Mee, J. M., Iwata, K., Pan, Q., Fearns, C., et al. N-(3-oxo-acyl)homoserine lactones signal cell activation through a mechanism distinct from the canonical pathogen-associated molecular pattern recognition receptor pathways Journal of Biological Chemistry  2006 281:28822-28830  DOI:10.1074/jbc.M606613200  PMID:16893899
    • Zorrilla, E. P., Iwasaki, S., Moss, J. A., Chang, J., Otsuji, J., Inoue, K., Meijler, M. M., Janda, K. D. Vaccination against weight gain Proceedings of the National Academy of Sciences of the United States of America  2006 103:13226-13231  DOI:10.1073/pnas.0605376103  PMID:16891413  PMCID:PMC1559781
    • Kim, Y., Lillo, A. M., Steiniger, S. C. J., Liu, Y., Ballatore, C., Anichini, A., Mortarini, R., Kaufmann, G. F., Zhou, B., Felding-Habermann, B., Janda, K. D. Targeting heat shock proteins on cancer cells: Selection, characterization, and cell-penetrating properties of a peptidic GRP78 ligand Biochemistry  2006 45:9434-9444  DOI:10.1021/bi060264j  PMID:16878978
    • Fu, Z. J., Chen, S., Baldwin, M. R., Boldt, G. E., Crawford, A., Janda, K. D., Barbieri, J. T., Kim, J. J. P. Light chain of botulinum neurotoxin serotype A: Structural resolution of a catalytic intermediate Biochemistry  2006 45:8903-8911  DOI:10.1021/bi060786z  PMID:16846233
    • Xu, Y., Lu, H., Kennedy, J. P., Yan, X. X., McAllister, L. A., Yamamoto, N., Moss, J. A., Boldt, G. E., Jiang, S. B., Janda, K. D. Evaluation of "credit card" libraries for inhibition of HIV-1 gp41 fusogenic core formation Journal of Combinatorial Chemistry  2006 8:531-539  DOI:10.1021/cc0600167  PMID:16827565  PMCID:PMC2529179
    • Boldt, G. E., Kennedy, J. P., Hixon, M. S., McAllister, L. A., Barbieri, J. T., Tzipori, S., Janda, K. D. Synthesis, characterization and development of a high-throughput methodology for the discovery of botulinum neurotoxin A inhibitors Journal of Combinatorial Chemistry  2006 8:513-521  DOI:10.1021/cc060010h  PMID:16827563  PMCID:PMC2644723
    • Ma, H. Z., Zhou, B., Kim, Y., Janda, K. D. A cyclic peptide-polymer probe for the detection of Clostridium botulinum neurotoxin serotype A Toxicon  2006 47:901-908  DOI:10.1016/j.toxicon.2006.03.003  PMID:16730044
    • Xu, Y., Shi, J., Yamamoto, N., Moss, J. A., Vogt, P. K., Janda, K. D. A credit-card library approach for disrupting protein-protein interactions Bioorganic & Medicinal Chemistry  2006 14:2660-2673  DOI:10.1016/j.bmc.2005.11.052  PMID:16384710
    • Boldt, G. E., Kennedy, J. P., Janda, K. D. Identification of a potent botulinum neurotoxin a protease inhibitor using in situ lead identification chemistry Organic Letters  2006 8:1729-1732  DOI:10.1021/ol0603211  PMID:16597152  PMCID:PMC2733786
    • McAllister, L. A., Hixon, M. S., Kennedy, J. P., Dickerson, T. J., Janda, K. D. Superactivation of the botulinum neurotoxin serotype A light chain metalloprotease: A new wrinkle in botulinum neurotoxin Journal of the American Chemical Society  2006 128:4176-4177  DOI:10.1021/ja057699z  PMID:16568962  PMCID:PMC2529174
    • Moss, J. A., Stokols, S., Hixon, M. S., Ashley, F. T., Chang, J. Y., Janda, K. D. Solid-phase synthesis and kinetic characterization of fluorogenic enzyme-degradable hydrogel cross-linkers Biomacromolecules  2006 7:1011-1016  DOI:10.1021/bm051001s  PMID:16602715  PMCID:PMC2546486
    • Kaufmann, G. F., Sartorio, R., Lee, S. H., Mee, J. M., Altobell, L. J., Kujawa, D. P., Jeffries, E., Clapham, B., Meijler, M. M., Janda, K. D. Antibody interference with N-acyl homoserine lactone-mediated bacterial quorum sensing Journal of the American Chemical Society  2006 128:2802-2803  DOI:10.1021/ja0578698  PMID:16506750  PMCID:PMC2546487
    • Shigenaga, A., Moss, J. A., Ashley, F. T., Kaufmann, G. F., Janda, K. D. Solid-phase synthesis and cyclative cleavage of quorum sensing depsipeptide analogues by acylphenyldiazene activation Synlett  2006 551-554  DOI:10.1055/s-2006-9325468
    • Zhu, X. Y., Dickerson, T. J., Rogers, C. J., Kaufmann, G. F., Mee, J. M., McKenzie, K. M., Janda, K. D., Wilson, I. A. Complete reaction cycle of a cocaine catalytic antibody at atomic resolution Structure  2006 14:205-216  DOI:10.1016/j.str.2005.10.014  PMID:16472740
    • Boldt, G. E., Dickerson, T. J., Janda, K. D. Emerging chemical and biological approaches for the preparation of discovery libraries Drug Discovery Today  2006 11:143-148  DOI:10.1016/s1359-6446(05)03697-4  PMID:16533712
    • Zhang, L. G., Long, H., Boldt, G. E., Janda, K. D., Schatz, G. C., Lewis, F. D. α- and β-Stilbenosides as base-pair surrogates in DNA hairpins Organic & Biomolecular Chemistry  2006 4:314-322  DOI:10.1039/b513694f  PMID:16391774
    • Wu, W. Y., Luo, Y. P., Sun, C. Z., Liu, Y. A., Kuo, P., Varga, J., Xiang, R., Reisfeld, R., Janda, K. D., Edgington, T. S., Liu, C. Targeting cell-impermeable prodrug activation to tumor microenvironment eradicates multiple drug-resistant neoplasms Cancer Research  2006 66:970-980  DOI:10.1158/0008-5472.can-05-2591  PMID:16424032
    • Rogers, C. J., Dickerson, T. J., Janda, K. D. Kinetic isotope and thermodynamic analysis of the nornicotine-catalyzed aqueous aldol reaction Tetrahedron  2006 62:352-356  DOI:10.1016/j.tet.2005.09.094
    • Boldt, G. E., Eubanks, L. M., Janda, K. D. Identification of A botulinum neurotoxin a protease inhibitor displaying efficacy in a cellular model Chemical Communications  2006 3063-3065  DOI:10.1039/b603099h  PMID:16855686
    • Dickerson, T. J., Janda, K. D. The use of small molecules to investigate molecular mechanisms and therapeutic targets for treatment of botulinum neurotoxin A intoxication ACS Chemical Biology  2006 1:359-369  DOI:10.1021/cb600179d  PMID:17163773
    • Rogers, C. J., Dickerson, T. J., Wentworth, P., Janda, K. D. A high-swelling reagent scaffold suitable for use in aqueous and organic solvents Tetrahedron  2005 61:12140-12144  DOI:10.1016/j.tet.2005.07.115
    • Shimomura, O., Lee, B. S., Meth, S., Suzuki, H., Mahajan, S., Nomura, R., Janda, K. D. Synthesis and application of polytetrahydrofuran-grafted polystyrene (PS-PTHF) resin supports for organic synthesis Tetrahedron  2005 61:12160-12167  DOI:10.1016/j.tet.2005.08.121
    • Qi, L. W., Yamamoto, N., Meijler, M. M., Altobell, L. J., Koob, G. F., Wirsching, P., Janda, K. D. Delta(9)-tetrahydrocannabinol immunochemical studies: Haptens, monoclonal antibodies, and a convenient synthesis of radiolabeled delta(9)-tetrahydrocannabinol Journal of Medicinal Chemistry  2005 48:7389-7399  DOI:10.1021/jm050442r  PMID:16279798
    • Dickerson, T. J., Beuscher, A. E., Hixon, M. S., Yamamoto, N., Xu, Y., Olson, A. J., Janda, K. D. Discovery of acetylcholinesterase peripheral anionic site ligands through computational refinement of a directed library Biochemistry  2005 44:14845-14853  DOI:10.1021/bi051613x  PMID:16274232
    • Kim, Y., Lillo, A., Moss, J. A., Janda, K. D. A contiguous stretch of methionine residues mediates the energy-dependent internalization mechanism of a cell-penetrating peptide Molecular Pharmaceutics  2005 2:528-535  DOI:10.1021/mp050035b  PMID:16323960
    • Shute, T. S., Matsushita, M., Dickerson, T. J., La Clair, J. J., Janda, K. D., Burkart, M. D. A site-specific bifunctional protein labeling system for affinity and fluorescent analysis Bioconjugate Chemistry  2005 16:1352-1355  DOI:10.1021/bc050213j  PMID:16287229
    • Matsushita, M., Meijler, M. M., Wirsching, P., Lerner, R. A., Janda, K. D. A blue fluorescent anti body-cofactor sensor for mercury Organic Letters  2005 7:4943-4946  DOI:10.1021/ol051919w  PMID:16235928
    • Eubanks, L. M., Dickerson, T. J., Janda, K. D. Vitamin B-2-mediated cellular photoinhibition of botulinum neurotoxin A FEBS Letters  2005 579:5361-5364  DOI:10.1016/j.febslet.2005.08.072  PMID:16198354
    • Matsushita, H., Yamamoto, N., Meijler, M. M., Wirsching, P., Lerner, R. A., Matsushita, M., Janda, K. D. Chiral sensing using a blue fluorescent antibody Molecular Biosystems  2005 1:303-306  DOI:10.1039/b511408j  PMID:16880995
    • Xu, Y., Yamamoto, N., Ruiz, D. I., Kubitz, D. S., Janda, K. D. Squaric monoamide monoester as a new class of reactive immunization hapten for catalytic antibodies Bioorganic & Medicinal Chemistry Letters  2005 15:4304-4307  DOI:10.1016/j.bmcl.2005.06.052  PMID:16046128
    • Toker, J. D., Tremblay, M. R., Yli-Kauhaluoma, J., Wentworth, A. D., Zhou, B., Wentworth, P., Janda, K. D. Exploring the scope of the 29g12 antibody catalyzed 1,3-dipolar cycloaddition reaction Journal of Organic Chemistry  2005 70:7810-7815  DOI:10.1021/jo050410b  PMID:16277300
    • Yamashita, M., Lee, S. H., Koch, G., Zimmermann, J., Clapham, B., Janda, K. D. Solid-phase synthesis of oxazolones and other heterocycles via wang resin-bound diazocarbonyls Tetrahedron Letters  2005 46:5495-5498  DOI:10.1016/j.tetlet.2005.06.061
    • Carrera, M. R. A., Trigo, J. M., Wirsching, P., Roberts, A. J., Janda, K. D. Evaluation of the anticocaine monoclonal antibody GNC92H2 as an immunotherapy for cocaine overdose Pharmacology, Biochemistry and Behavior  2005 81:709-714  DOI:10.1016/j.pbb.2005.04.018  PMID:16005948
    • Brogan, A. P., Dickerson, T. J., Boldt, G. E., Janda, K. D. Altered retinoid homeostasis catalyzed by a nicotine metabolite: Implications in macular degenerationand and normal development Proceedings of the National Academy of Sciences of the United States of America  2005 102:10433-10438  DOI:10.1073/pnas.0504721102  PMID:16014706  PMCID:PMC1180800
    • Rogers, C. J., Mee, J. M., Kaufmann, G. F., Dickerson, T. J., Janda, K. D. Toward cocaine esterase therapeutics Journal of the American Chemical Society  2005 127:10016-10017  DOI:10.1021/ja053086a  PMID:16011362  PMCID:PMC1352337
    • Lee, B. S., Mahajan, S., Janda, K. D. Asymmetric dihydroxylation catalyzed by ionic polymer-supported osmium tetroxide Tetrahedron Letters  2005 46:4491-4493  DOI:10.1016/j.tetlet.2005.04.113
    • Dickerson, T. J., Kaufmann, G. F., Janda, K. D. Bacteriophage-mediated protein delivery into the central nervous system and its application in immunopharmacotherapy Expert Opinion on Biological Therapy  2005 5:773-781  DOI:10.1517/14712598.5.6.773  PMID:15952908
    • Lee, B. S., Mahajan, S., Janda, K. D. Molecular iodine-catalyzed imine activation for three-component nucleophilic addition reactions Synlett  2005 1325-1327  DOI:10.1055/s-2005-838487
    • Lowery, C. A., McKenzie, K. M., Qi, L. W., Meijler, M. M., Janda, K. D. Quorum sensing in Vibrio harveyi: Probing the specificity of the LuxP binding site Bioorganic & Medicinal Chemistry Letters  2005 15:2395-2398  DOI:10.1016/j.bmcl.2005.02.069  PMID:15837332
    • Rogers, C. J., Dickerson, T. J., Brogan, A. P., Janda, K. D. Hammett correlation of nornicotine analogues in the aqueous aldol reaction: Implications for green organocatalysis Journal of Organic Chemistry  2005 70:3705-3708  DOI:10.1021/jo050161r  PMID:15845010
    • Lee, B. S., Mahajan, S., Janda, K. D. Cross-linked poly(4-vinylpyridine/styrene) copolymers as a support for immobilization of ytterbium triflate Tetrahedron  2005 61:3081-3086  DOI:10.1016/j.tet.2005.01.068
    • Reed, N. N., Dickerson, T. J., Boldt, G. E., Janda, K. D. Enantioreversal in the sharpless asymmetric epoxidation reaction controlled by the molecular weight of a covalently appended achiral polymer Journal of Organic Chemistry  2005 70:1728-1731  DOI:10.1021/jo048009x  PMID:15730294
    • Meijler, M. M., Kaufmann, G. F., Qi, L. W., Mee, J. M., Coyle, A. R., Moss, J. A., Wirsching, P., Matsushita, M., Janda, K. D. Fluorescent cocaine probes: A tool for the selection and engineering of therapeutic antibodies Journal of the American Chemical Society  2005 127:2477-2484  DOI:10.1021/ja043935e  PMID:15725002
    • Lee, B. S., Mahajan, S., Janda, K. D. Novel method for catalyst immobilization using an ionic polymer: A case study using recyclable ytterbium triflate Tetrahedron Letters  2005 46:807-810  DOI:10.1016/j.tetlet.2004.12.013
    • Moss, J. A., Lillo, A., Kim, Y., Gao, C., Ditzel, H., Janda, K. D. A dimerization "switch" in the internalization mechanism of a cell-penetrating peptide Journal of the American Chemical Society  2005 127:538-539  DOI:10.1021/ja0443171  PMID:15643874
    • Kaufmann, G. F., Sartorio, R., Lee, S. H., Rogers, C. J., Meijler, M. M., Moss, J. A., Clapham, B., Brogan, A. P., Dickerson, T. J., Janda, K. D. Revisiting quorum sensing: Discovery of additional chemical and biological functions for 3-oxo-N-acylhomoserine lactones Proceedings of the National Academy of Sciences of the United States of America  2005 102:309-314  DOI:10.1073/pnas.0408639102  PMID:15623555  PMCID:PMC544315
    • McKenzie, K. M., Meijler, M. M., Lowery, C. A., Boldt, G. E., Janda, K. D. A furanosyl-carbonate autoinducer in cell-to-cell communication of v-harveyi Chemical Communications  2005 4863-4865  DOI:10.1039/b509396a
    • Kaufmann, G. F., Meijler, M. M., Sun, C. Z., Chen, D. W., Kujawa, D. P., Mee, J. M., Hoffman, T. Z., Wirsching, P., Lerner, R. A., Janda, K. D. Enzymatic incorporation of an antibody-activated blue fluorophore into DNA Angewandte Chemie-International Edition  2005 44:2144-2148  DOI:10.1002/anie.200461143  PMID:15742317
    • Dickerson, T. J., Reed, N. N., LaClair, J. J., Janda, K. D. A precipitator for the detection of thiophilic metals in aqua Journal of the American Chemical Society  2004 126:16582-16586  DOI:10.1021/ja045798r  PMID:15600364
    • Lee, S. H., Yoshida, K., Matsushita, H., Clapham, B., Koch, G., Zimmermann, J., Janda, K. D. N-H insertion reactions of primary ureas: The synthesis of highly substituted imidazolones and imidazoles from diazocarbonyls Journal of Organic Chemistry  2004 69:8829-8835  DOI:10.1021/jo048353u  PMID:15575764
    • Felding-Habermann, B., Lerner, R. A., Lillo, A., Zhuang, S. F., Weber, M. R., Arrues, S., Gao, C., Mao, S. L., Saven, A., Janda, K. D. Combinatorial antibody libraries from cancer patients yield ligand-mimetic Arg-Gly-Asp-containing immunoglobulins that inhibit breast cancer metastasis Proceedings of the National Academy of Sciences of the United States of America  2004 101:17210-17215  DOI:10.1073/pnas.0407869101  PMID:15563590  PMCID:PMC534417
    • Matsushita, H., Lee, S. H., Yoshida, K., Clapham, B., Koch, G., Zimmermann, J., Janda, K. D. N-H insertion reactions of Boc-amino acid amides: Solution- and solid-phase synthesis of pyrazinones and pyrazines Organic Letters  2004 6:4627-4629  DOI:10.1021/ol047933a  PMID:15548092
    • Kim, Y., Moss, J. A., Janda, K. D. Biological tuning of synthetic tactics in solid-phase synthesis: Application to A beta(1-42) Journal of Organic Chemistry  2004 69:7776-7778  DOI:10.1021/jo048922y  PMID:15498016
    • Xu, Y., Yamamoto, N., Janda, K. D. Catalytic antibodies: Hapten design strategies and screening methods Bioorganic & Medicinal Chemistry  2004 12:5247-5268  DOI:10.1016/j.bmc.2004.03.077  PMID:15388154
    • Carrera, M. R. A., Meijler, M. M., Janda, K. D. Cocaine pharmacology and current pharmacothetherapies for its abuse Bioorganic & Medicinal Chemistry  2004 12:5019-5030  DOI:10.1016/j.bmc.2004.06.018  PMID:15351386
    • Dickerson, T. J., Lovell, T., Meijler, M. M., Noodleman, L., Janda, K. D. Nornicotine aqueous aldol reactions: synthetic and theoretical investigations into the origins of catalysis Journal of Organic Chemistry  2004 69:6603-6609  DOI:10.1021/jo048894j  PMID:15387581
    • Dickerson, T. J., Yamamoto, N., Ruiz, D. I., Janda, K. D. Immunological consequences of methamphetamine protein glycation Journal of the American Chemical Society  2004 126:11446-11447  DOI:10.1021/ja047690h  PMID:15366884
    • Dickerson, T. J., Yamamoto, N., Janda, K. D. Antibody-catalyzed oxidative degradation of nicotine using riboflavin Bioorganic & Medicinal Chemistry  2004 12:4981-4987  DOI:10.1016/j.bmc.2004.07.006  PMID:15336277
    • Lee, S. H., Matsushita, H., Koch, G., Zimmermann, J., Clapham, B., Janda, K. D. Smart cleavage reactions: The synthesis of an array of ureas from polymer-bound carbamates Journal of Combinatorial Chemistry  2004 6:822-827  DOI:10.1021/cc049916i  PMID:15360219
    • Carrera, M. R. A., Kaufmann, G. F., Mee, J. M., Meijler, M. M., Koob, G. F., Janda, K. D. Treating cocaine addiction with viruses Proceedings of the National Academy of Sciences of the United States of America  2004 101:10416-10421  DOI:10.1073/pnas.0403795101  PMID:15226496  PMCID:PMC478586
    • Lillo, A. M., Sun, C. Z., Gao, C., Ditzel, H., Parrish, J., Gauss, C. M., Moss, J., Felding-Habermann, B., Wirsching, P., Boger, D. L., Janda, K. D. A human single-chain antibody specific for integrin alpha(3)beta(1) capable of cell internalization and delivery of antitumor agents Chemistry & Biology  2004 11:897-906  DOI:10.1016/j.chembiol.2004.04.018  PMID:15271348
    • Lee, B. S., Mahajan, S., Clapham, B., Janda, K. D. Suspension ring-opening metathesis polymerization: The preparation of norbornene-based resins for application in organic synthesis Journal of Organic Chemistry  2004 69:3319-3329  DOI:10.1021/jo049827s  PMID:15132537
    • Qi, L. W., Meijler, M. M., Lee, S. H., Sun, C. Z., Janda, K. D. Solid-phase synthesis of anandamide analogues Organic Letters  2004 6:1673-1675  DOI:10.1021/ol049474j  PMID:15128264
    • Lee, S. H., Matsushita, H., Clapham, B., Janda, K. D. The direct conversion of carbamates to ureas using aluminum amides Tetrahedron  2004 60:3439-3443  DOI:10.1016/j.tet.2004.02.034
    • Meijler, M. M., Hom, L. G., Kaufmann, G. F., McKenzie, K. M., Sun, C. Z., Moss, J. A., Matsushita, M., Janda, K. D. Synthesis and biological validation of a ubiquitous quorum-sensing molecule Angewandte Chemie-International Edition  2004 43:2106-2108  DOI:10.1002/anie.200353150  PMID:15083457
    • Ahn, J. M., Wentworth, P., Janda, K. D. Probing lipase/esterase libraries for lipid A hydrolases - discovery of biocatalysts for the detoxification of bacterially-expressed recombinant protein Chemical Communications  2004 364-365  DOI:10.1039/b312662e
    • Carrera, M. R. A., Ashley, J. A., Hoffman, T. Z., Isomura, S., Wirsching, P., Koob, G. F., Janda, K. D. Investigations using immunization to attenuate the psychoactive effects of nicotine Bioorganic & Medicinal Chemistry  2004 12:563-570  DOI:10.1016/j.bmc.2003.11.029  PMID:14738965
    • Matsushita, H., Lee, S. H., Joung, M., Clapham, B., Janda, K. D. Smart cleavage reactions: The synthesis of benzimidazoles and benzothiazoles from polymer-bound esters Tetrahedron Letters  2004 45:313-316  DOI:10.1016/j.tetlet.2003.10.168
    • Dickerson, T. J., Tremblay, M. R., Hoffman, T. Z., Ruiz, D. I., Janda, K. D. Catalysis of the photo-Fries reaction: Antibody-mediated stabilization of high energy states Journal of the American Chemical Society  2003 125:15395-15401  DOI:10.1021/ja038016n  PMID:14664584
    • Chen, Y. P., Gambs, C., Abe, Y., Wentworth, P., Janda, K. D. Total synthesis of the depsipeptide FR-901375 Journal of Organic Chemistry  2003 68:8902-8905  DOI:10.1021/jo034765b  PMID:14604360
    • Wentworth, P., Nieva, J., Takeuchi, C., Galve, R., Wentworth, A. D., Dilley, R. B., DeLaria, G. A., Saven, A., Babior, B. M., Janda, K. D., Eschenmoser, A., Lerner, R. A. Evidence for ozone formation in human atherosclerotic arteries Science  2003 302:1053-1056  DOI:10.1126/science.1089525  PMID:14605372
    • Moss, J. A., Coyle, A. R., Ahn, J. M., Meijler, M. M., Offer, J., Janda, K. D. Tandem IMAC-HPLC purification of a cocaine-binding scFv antibody Journal of Immunological Methods  2003 281:143-148  DOI:10.1016/j.jim.2003.07.010  PMID:14580888
    • Fujimori, T., Wirsching, P., Janda, K. D. Preparation of a Krohnke pyridine combinatorial library suitable for solution-phase biological screening Journal of Combinatorial Chemistry  2003 5:625-631  DOI:10.1021/cc0300208
    • Dickerson, T. J., Janda, K. D. Glycation of the amyloid beta-protein by a nicotine metabolite: A fortuitous chemical dynamic between smoking and Alzheimer's disease Proceedings of the National Academy of Sciences of the United States of America  2003 100:8182-8187  DOI:10.1073/pnas.1332847100  PMID:12815102  PMCID:PMC166203
    • Meijler, M. M., Matsushita, M., Altobelli, L. J., Wirsching, P., Janda, K. D. A new strategy for improved nicotine vaccines using conformationally constrained haptens Journal of the American Chemical Society  2003 125:7164-7165  DOI:10.1021/ja034805t  PMID:12797775
    • Redwan, E. R. M., Larsen, N. A., Zhou, B., Wirsching, P., Janda, K. D., Wilson, I. A. Expression and characterization of a humanized cocaine-binding antibody Biotechnology and Bioengineering  2003 82:612-618  DOI:10.1002/bit.10598  PMID:12652485
    • Liu, C., Sun, C. Z., Huang, H. N., Janda, K., Edgington, T. Overexpression of legumain in tumors is significant for invasion/metastasis and a candidate enzymatic target for prodrug therapy Cancer Research  2003 63:2957-2964  PMID:12782603
    • Zhu, X. Y., Heine, A., Monnat, F., Houk, K. N., Janda, K. D., Wilson, I. A. Structural basis for antibody catalysis of a cationic cyclization reaction Journal of Molecular Biology  2003 329:69-83  DOI:10.1016/s0022-2836(03)00406-6  PMID:12742019
    • Gambs, C., Dickerson, T. J., Mahajan, S., Pasternack, L. B., Janda, K. D. High-resolution diffusion-ordered spectroscopy to probe the microenvironment of JandaJel and Merrifield resins Journal of Organic Chemistry  2003 68:3673-3678  DOI:10.1021/jo034152z  PMID:12713377
    • Sun, C. Z., Wirsching, P., Janda, K. D. Enabling ScFvs as multi-drug carriers: A dendritic approach Bioorganic & Medicinal Chemistry  2003 11:1761-1768  DOI:10.1016/s0968-0896(03)00057-9  PMID:12659762
    • Cannizzaro, C. E., Ashley, J. A., Janda, K. D., Houk, K. N. Experimental determination of the absolute enantioselectivity of an anti body-catalyzed Diels-Alder reaction and theoretical explorations of the origins of stereoselectivity Journal of the American Chemical Society  2003 125:2489-2506  DOI:10.1021/ja020879d  PMID:12603137
    • Gao, C., Mao, S. L., Ronca, F., Zhuang, S. F., Quaranta, V., Wirsching, P., Janda, K. D. De novo identification of tumor-specific internalizing human antibody-receptor pairs by phage-display methods Journal of Immunological Methods  2003 274:185-197  DOI:10.1016/s0022-1759(02)00522-7  PMID:12609544
    • Lee, S. H., Clapham, B., Koch, G., Zimmermann, J., Janda, K. D. Solid-phase rhodium carbenoid n-h insertion reactions: The synthesis of a diverse array of indoles Journal of Combinatorial Chemistry  2003 5:188-196  DOI:10.1021/cc020079z  PMID:12625710
    • Lee, S. H., Clapham, B., Koch, G., Zimmermann, J., Janda, K. D. Rhodium carbenoid N-H insertion reactions of primary ureas: Solution and solid-phase synthesis of imidazolones Organic Letters  2003 5:511-514  DOI:10.1021/ol020244j  PMID:12583756
    • Wentworth, P., Wentworth, A. D., Zhu, X. Y., Wilson, I. A., Janda, K. D., Eschenmoser, A., Lerner, R. A. Evidence for the production of trioxygen species during antibody-catalyzed chemical modification of antigens Proceedings of the National Academy of Sciences of the United States of America  2003 100:1490-1493  DOI:10.1073/pnas.0437831100  PMID:12576548  PMCID:PMC149858
    • Wang, Q., Raja, K. S., Janda, K. D., Lin, T. W., Finn, M. G. Blue fluorescent antibodies as reporters of steric accessibility in virus conjugates Bioconjugate Chemistry  2003 14:38-43  DOI:10.1021/bc025587g  PMID:12526690
    • Matsushita, M., Yoshida, K., Yamamoto, N., Wirsching, P., Lerner, R. A., Janda, K. D. High-throughput screening by using a blue-fluorescent antibody sensor Angewandte Chemie-International Edition  2003 42:5984-5987  DOI:10.1002/anie.200352793  PMID:14679549
    • Ahn, J. M., Wentworth, P., Janda, K. D. Soluble polymer-supported convergent parallel library synthesis Chemical Communications  2003 480-481  DOI:10.1039/b210696e  PMID:12638959
    • Wentworth, P., McDunn, J. E., Wentworth, A. D., Takeuchi, C., Nieva, J., Jones, T., Bautista, C., Ruedi, J. M., Gutierrez, A., Janda, K. D., Babior, B. M., Eschenmoser, A., et al. Evidence for antibody-catalyzed ozone formation in bacterial killing and inflammation Science  2002 298:2195-2199  DOI:10.1126/science.1077642  PMID:12434011
    • Gao, C., Mao, S. L., Ditzel, H. J., Farnaes, L., Wirsching, P., Lerner, R. A., Janda, K. D. A cell-penetrating peptide from a novel pVII-pIX phage-displayed random peptide library Bioorganic & Medicinal Chemistry  2002 10:4057-4065  DOI:10.1016/s0968-0896(02)00340-1  PMID:12413859
    • Dickerson, T. J., Janda, K. D. A previously undescribed chemical link between smoking and metabolic disease Proceedings of the National Academy of Sciences of the United States of America  2002 99:15084-15088  DOI:10.1073/pnas.222561699  PMID:12403823  PMCID:PMC137547
    • Lee, K. J., Mao, S. L., Sun, C. Z., Gao, C., Blixt, O., Arrues, S., Hom, L. G., Kaufmann, G. F., Hoffman, T. Z., Coyle, A. R., Paulson, J., Felding-Habermann, B., et al. Phage-display selection of a human single-chain fv antibody highly specific for melanoma and breast cancer cells using a chemoenzymatically synthesized G(M3)-carbohydrate antigen Journal of the American Chemical Society  2002 124:12439-12446  DOI:10.1021/ja020737j  PMID:12381184
    • Gao, C., Mao, S. L., Kaufmann, G., Wirsching, P., Lerner, R. A., Janda, K. D. A method for the generation of combinatorial antibody libraries using pIX phage display Proceedings of the National Academy of Sciences of the United States of America  2002 99:12612-12616  DOI:10.1073/pnas.192467999  PMID:12239343  PMCID:PMC130508
    • Delgado, M., Janda, K. D. Polymeric supports for solid phase organic synthesis Current Organic Chemistry  2002 6:1031-1043  DOI:10.2174/1385272023373671
    • Dickerson, T. J., Reed, N. N., Janda, K. D. Soluble polymers as scaffolds for recoverable catalysts and reagents Chemical Reviews  2002 102:3325-3343  DOI:10.1021/cr010335e  PMID:12371887
    • Shimomura, O., Clapham, B., Spanka, C., Mahajan, S., Janda, K. D. Application of microgels as polymer supports for organic synthesis: Preparation of a small phthalide library, a scavenger, and a borohydride reagent Journal of Combinatorial Chemistry  2002 4:436-441  DOI:10.1021/cc020012b  PMID:12217015
    • Sun, C. Z., Wirsching, P., Janda, K. D. Syntheses of dendritic linkers containing chlorambucil residues for the preparation of antibody-multidrug immunoconjugates Bioorganic & Medicinal Chemistry Letters  2002 12:2213-2215  DOI:10.1016/s0960-894x(02)00361-x  PMID:12127540
    • Reed, N. N., Delgado, M., Hereford, K., Clapham, B., Janda, K. D. Preparation of soluble and insoluble polymer supported IBX reagents Bioorganic & Medicinal Chemistry Letters  2002 12:2047-2049  DOI:10.1016/s0960-894x(02)00264-0  PMID:12113839
    • Clapham, B., Lee, S. H., Koch, G., Zimmermann, J., Janda, K. D. The preparation of polymer bound beta-ketoesters and their conversion into an array of oxazoles Tetrahedron Letters  2002 43:5407-5410  DOI:10.1016/s0040-4039(02)01076-6
    • Boyle, N. A., Janda, K. D. Formats for combinatorial synthesis: Solid-phase, liquid-phase and surface Current Opinion in Chemical Biology  2002 6:339-346  DOI:10.1016/s1367-5931(02)00308-3  PMID:12023115
    • Delgado, M., Lee, K. J., Altobell, L., Spanka, C., Wentworth, P., Janda, K. D. A parallel approach to the discovery of carrier delivery vehicles to enhance antigen immunogenicity Journal of the American Chemical Society  2002 124:4946-4947  DOI:10.1021/ja025715b  PMID:11982344
    • Spanka, C., Clapham, B., Janda, K. D. Preparation of new microgel polymers and their application as supports in organic synthesis Journal of Organic Chemistry  2002 67:3045-3050  DOI:10.1021/jo016362m  PMID:11975565
    • Spanka, C., Wentworth, P., Janda, K. D. Developing soluble polymers for high-throughput synthetic chemistry Combinatorial Chemistry & High Throughput Screening  2002 5:233-240  PMID:11966431
    • Kim, G. T., Wenz, M., Park, J. I., Hasserodt, J., Janda, K. D. Polyene substrates with unusual methylation patterns to probe the active sites of three catalytic antibodies Bioorganic & Medicinal Chemistry  2002 10:1249-1262  DOI:10.1016/s0968-0896(01)00402-3  PMID:11886788
    • Zhou, B., Wirsching, P., Janda, K. D. Human antibodies against Bacillus: A model study for detection of an protection against anthrax and the bioterrorist threat Proceedings of the National Academy of Sciences of the United States of America  2002 99:5241-5246  DOI:10.1073/pnas.082121599  PMID:11959974  PMCID:PMC122754
    • Isomura, S., Hoffman, T. Z., Wirsching, P., Janda, K. D. Synthesis, properties, and reactivity of cocaine benzoylthio ester possessing the cocaine absolute configuration Journal of the American Chemical Society  2002 124:3661-3668  DOI:10.1021/ja012376y  PMID:11929256
    • Dickerson, T. J., Janda, K. D. Aqueous aldol catalysis by a nicotine metabolite Journal of the American Chemical Society  2002 124:3220-3221  DOI:10.1021/ja017774f  PMID:11916401
    • Matsushita, M., Janda, K. D. Histidine kinases as targets for new antimicrobial agents Bioorganic & Medicinal Chemistry  2002 10:855-867  DOI:10.1016/s0968-0896(01)00355-8  PMID:11836091
    • Isomura, S., Ashley, J. A., Wirsching, P., Janda, K. D. Antibody-catalyzed cleavage of the D-Ala-D-Lac depsipeptide: An immunological approach to the problem of vancomycin resistance Bioorganic & Medicinal Chemistry Letters  2002 12:861-864  DOI:10.1016/s0960-894x(02)00047-1  PMID:11958980
    • Reger, T. S., Janda, K. D. Parallel suspension polymerization for high-throughput resin synthesis Bioorganic & Medicinal Chemistry Letters  2002 12:837-840  DOI:10.1016/s0960-894x(02)00046-x  PMID:11958974
    • Nicholas, K. M., Wentworth, P., Harwig, C. W., Wentworth, A. D., Shafton, A., Janda, K. D. A cofactor approach to copper-dependent catalytic antibodies Proceedings of the National Academy of Sciences of the United States of America  2002 99:2648-2653  DOI:10.1073/pnas.052001099  PMID:11880619  PMCID:PMC122402
    • Delgado, M., Spanka, C., Kerwin, L. D., Wentworth, P., Janda, K. D. A tunable hydrogel for encapsulation and controlled release of bioactive proteins Biomacromolecules  2002 3:262-271  DOI:10.1021/bm010147y  PMID:11888310
    • Delgado, M., Spanka, C., Kerwin, L. D., Wentworth, P., Janda, K. M. Tunable hydrogel for encapsulation and controlled release of bioactive proteins Biomacromolecules  2002 3:262-271  DOI:10.1021/bm010147y  PMID:11888310
    • Jones, L. H., Altobell, L. J., MacDonald, M. T., Boyle, N. A., Wentworth, P., Lerner, R. A., Janda, K. D. Active immunization with a glycolipid transition state analogue protects against endotoxic shock Angewandte Chemie-International Edition  2002 41:4241-4244  DOI:10.1002/1521-3773(20021115)41:22<4241::aid-anie4241>3.0.co;2-n  PMID:12434351
    • Moss, J. A., Dickerson, T. J., Janda, K. D. Solid phase peptide synthesis on JandaJel(TM) resin Tetrahedron Letters  2002 43:37-40  DOI:10.1016/s0040-4039(01)02076-7
    • Lee, K. J., Janda, K. D. Traceless solid-phase synthesis of 5-benzoylbenzimidazoles Canadian Journal of Chemistry-Revue Canadienne De Chimie  2001 79:1556-1561  DOI:10.1139/cjc-79-11-1556
    • Kozlov, I. A., Mao, S. L., Xu, Y., Huang, X. F., Lee, L., Sears, P. S., Gao, C., Coyle, A. R., Janda, K. D., Wong, C. H. Synthesis of solid-supported mirror-image sugars: A novel method for selecting receptors for cellular-surface carbohydrates ChemBioChem  2001 2:741-746  DOI:10.1002/1439-7633(20011001)2:10<741::aid-cbic741>3.0.co;2-b  PMID:11948856
    • Wentworth, P., Jones, L. H., Wentworth, A. D., Zhu, X. Y., Larsen, N. A., Wilson, I. A., Xu, X., Goddard, W. A., Janda, K. D., Eschenmoser, A., Lerner, R. A. Antibody catalysis of the oxidation of water Science  2001 293:1806-1811  DOI:10.1126/science.1062722  PMID:11546867
    • Brummer, O., Hoffman, T. Z., Janda, K. D. Metalloantibodies: Mercury(II)-dependent acyl transferases Bioorganic & Medicinal Chemistry  2001 9:2253-2257  DOI:10.1016/s0968-0896(01)00089-x  PMID:11553463
    • Cordova, A., Janda, K. D. Synthesis and catalytic antibody functionalization of dendrimers Journal of the American Chemical Society  2001 123:8248-8259  DOI:10.1021/ja001819f  PMID:11516276
    • Cordova, A., Tremblay, M. R., Clapham, B., Janda, K. D. A sequential application of kinetic resolution and polymer-supported scavenging for the isolation of chiral secondary alcohols Journal of Organic Chemistry  2001 66:5645-5648  DOI:10.1021/jo010529u  PMID:11485501
    • Larsen, N. A., Zhou, B., Heine, A., Wirsching, P., Janda, K. D., Wilson, I. A. Crystal structure of a cocaine-binding antibody Journal of Molecular Biology  2001 311:9-15  DOI:10.1006/jmbi.2001.4839  PMID:11469854
    • Tremblay, M. R., Dickerson, T. J., Janda, K. D. Advances in antibody catalysis of cycloaddition reactions Advanced Synthesis & Catalysis  2001 343:577-585  DOI:10.1002/1615-4169(200108)343:6/7<577::aid-adsc577>3.0.co;2-z
    • Clapham, B., Spanka, C., Janda, K. D. Solid-phase rhodium carbenoid reactions: An N-H insertion route to a diverse series of oxazoles Organic Letters  2001 3:2173-2176  DOI:10.1021/ol010075n  PMID:11440572
    • Dickerson, T. J., Reed, N. N., Janda, K. D. Regio-reactive resin: A platform for orthogonal loading using the polymer backbone and cross-linker Bioorganic & Medicinal Chemistry Letters  2001 11:1507-1509  DOI:10.1016/s0960-894x(01)00152-4  PMID:11412970
    • Isomura, S., Wirsching, P., Janda, K. D. An immunotherapeutic program for the treatment of nicotine addiction: Hapten design and synthesis Journal of Organic Chemistry  2001 66:4115-4121  DOI:10.1021/jo001442w  PMID:11397142
    • Clapham, B., Reger, T. S., Janda, K. D. Polymer-supported catalysis in synthetic organic chemistry Tetrahedron  2001 57:4637-4662  DOI:10.1016/s0040-4020(01)00298-8
    • Jones, L. H., Harwig, C. W., Wentworth, P., Simeonov, A., Wentworth, A. D., Py, S., Ashley, J. A., Lerner, R. A., Janda, K. D. Conversion of enediynes into quinones by antibody catalysis and in aqueous buffers: Implications for an alternative enediynes therapeutic mechanism Journal of the American Chemical Society  2001 123:3607-3608  DOI:10.1021/ja005864z  PMID:11472138
    • Brummer, O., La Clair, J. J., Janda, K. D. Practical screening of mercury contamination in fish tissue Bioorganic & Medicinal Chemistry  2001 9:1067-1071  DOI:10.1016/s0968-0896(01)00049-9  PMID:11354663
    • Brummer, O., Clapham, B., Janda, K. D. Solid-phase synthesis of oligoesters using a JandaJel (tm) resin Tetrahedron Letters  2001 42:2257-2259  DOI:10.1016/s0040-4039(01)00172-1
    • Wen, K., Han, H. S., Hoffman, T. Z., Janda, K. D., Orgel, L. E. The synthesis of beta-peptides containing guanidino groups Bioorganic & Medicinal Chemistry Letters  2001 11:689-691  DOI:10.1016/s0960-894x(01)00027-0  PMID:11266170
    • Cordova, A., Janda, K. D. A highly chemo- and stereoselective synthesis of beta-keto esters via a polymer-supported lipase catalyzed transesterfication Journal of Organic Chemistry  2001 66:1906-1909  DOI:10.1021/jo001478o  PMID:11262145
    • Chen, D. W., Beuscher, A. E., Stevens, R. C., Wirsching, P., Lerner, R. A., Janda, K. D. Preparation of stilbene-tethered nonnatural nucleosides for use with blue-fluorescent antibodies Journal of Organic Chemistry  2001 66:1725-1732  DOI:10.1021/jo001676f  PMID:11262119
    • Carrera, M. R. A., Ashley, J. A., Wirsching, P., Koob, G. F., Janda, K. D. A second-generation vaccine protects against the psychoactive effects of cocaine Proceedings of the National Academy of Sciences of the United States of America  2001 98:1988-1992  DOI:10.1073/pnas.041610998  PMID:11172063
    • Clapham, B., Cho, C. W., Janda, K. D. A polymer-supported proline-based diamine catalyst for the kinetic resolution of racemic secondary alcohols Journal of Organic Chemistry  2001 66:868-873  DOI:10.1021/jo0013610  PMID:11430106
    • Matsushita, M., Hoffman, T. Z., Ashley, J. A., Zhou, B., Wirsching, P., Janda, K. D. Cocaine catalytic antibodies: The primary importance of linker effects Bioorganic & Medicinal Chemistry Letters  2001 11:87-90  DOI:10.1016/s0960-894x(00)00659-4  PMID:11206477
    • Brummer, O., Hoffman, T. Z., Chen, D. W., Janda, K. D. Antibody-catalyzed hydrolysis of oligomeric esters: A model for the degradation of polymeric materials Chemical Communications  2001 19-20  DOI:10.1039/b008065i
    • Wentworth, P., Janda, K. D. Catalytic antibodies - structure and function Cell Biochemistry and Biophysics  2001 35:63-87  DOI:10.1385/cbb:35:1:63  PMID:11898856
    • Toy, P. H., Reger, T. S., Garibay, P., Garno, J. C., Malikayil, J. A., Liu, G. Y., Janda, K. D. Polytetrahydrofuran cross-linked polystyrene resins for solid-phase organic synthesis Journal of Combinatorial Chemistry  2001 3:117-124  DOI:10.1021/cc000083f  PMID:11148072
    • Chen, D. W., Kubiak, R. J., Ashley, J. A., Janda, K. D. Reactive immunization elicits catalytic antibodies for polyester hydrolysis Journal of the Chemical Society-Perkin Transactions 1  2001 2796-2803  DOI:10.1039/b105412k
    • Lopez-Pelegrin, J. A., Wentworth, P., Sieber, F., Metz, W. A., Janda, K. D. Soluble polymer-supported chemoenzymatic synthesis of the C21-C27 fragment of the bryostatins Journal of Organic Chemistry  2000 65:8527-8531  DOI:10.1021/jo005539u  PMID:11112572
    • Tremblay, M. R., Wentworth, P., Lee, G. E., Janda, K. D. Parallel solid-phase synthesis and structural characterization of a library of highly substituted chiral 1,3-oxazolidines Journal of Combinatorial Chemistry  2000 2:698-709  DOI:10.1021/cc0000500  PMID:11126298
    • Vaino, A. R., Janda, K. D. Solid-phase organic synthesis: A critical understanding of the resin Journal of Combinatorial Chemistry  2000 2:579-596  DOI:10.1021/cc000046o  PMID:11126287
    • Manzotti, R., Reger, T. S., Janda, K. D. Improved synthesis of (4-ethenylphenyl)diphenyl methanol and its application in the preparation of trityl functionalized polystyrene resin containing tetrahydrofuran derived cross-linker Tetrahedron Letters  2000 41:8417-8420  DOI:10.1016/s0040-4039(00)01529-x
    • Simeonov, A., Matsushita, M., Juban, E. A., Thompson, E. H. Z., Hoffman, T. Z., Beuscher, A. E., Taylor, M. J., Wirsching, P., Rettig, W., McCusker, J. K., Stevens, R. C., Millar, D. P., et al. Blue-fluorescent antibodies Science  2000 290:307-313  DOI:10.1126/science.290.5490.307  PMID:11030644
    • Manzotti, R., Tang, S. Y., Janda, K. D. Improved synthesis of prostanoids on a non-cross-linked polystyrene soluble support Tetrahedron  2000 56:7885-7892  DOI:10.1016/s0040-4020(00)00707-9
    • Wentworth, A. D., Jones, L. H., Wentworth, P., Janda, K. D., Lerner, R. A. Antibodies have the intrinsic capacity to destroy antigens Proceedings of the National Academy of Sciences of the United States of America  2000 97:10930-10935  DOI:10.1073/pnas.97.20.10930  PMID:11005865
    • Reed, N. N., Janda, K. D. A one-step synthesis of monoprotected polyethylene glycol ethers Journal of Organic Chemistry  2000 65:5843-5845  DOI:10.1021/jo000442t  PMID:10970334
    • Toy, P. H., Reger, T. S., Janda, K. D. Soluble polymer bound cleavage reagents: A multipolymer strategy for the cleavage of tertiary amines from REM resin Organic Letters  2000 2:2205-2207  DOI:10.1021/ol0059403  PMID:10930244
    • Reger, T. S., Janda, K. D. Polymer-supported (Salen)Mn catalysts for asymmetric epoxidation: A comparison between soluble and insoluble matrices Journal of the American Chemical Society  2000 122:6929-6934  DOI:10.1021/ja000692r
    • Vaino, A. R., Janda, K. D. Euclidean shape-encoded combinatorial chemical libraries Proceedings of the National Academy of Sciences of the United States of America  2000 97:7692-7696  DOI:10.1073/pnas.97.14.7692  PMID:10884401
    • Vaino, A. R., Goodin, D. B., Janda, K. D. Investigating resins for solid phase organic synthesis: The relationship between swelling and microenvironment as probed by EPR and fluorescence spectroscopy Journal of Combinatorial Chemistry  2000 2:330-336  DOI:10.1021/cc000007c  PMID:10891099
    • Manzotti, R., Janda, K. D. Solid and liquid phase chemistry: Development of new supports for solid phase organic synthesis and for liquid phase chemistry Chimica Oggi-Chemistry Today  2000 18:14-18
    • Lopez-Pelegrin, J. A., Janda, K. D. Solution- and soluble-polymer supported asymmetric syntheses of six-membered ring prostanoids Chemistry-a European Journal  2000 6:1917-1922  DOI:10.1002/1521-3765(20000602)6:11<1917::aid-chem1917>3.0.co;2-7  PMID:10894390
    • Carrera, M. R. A., Ashley, J. A., Zhou, B., Wirsching, P., Koob, G. F., Janda, K. D. Cocaine vaccines: Antibody protection against relapse in a rat model Proceedings of the National Academy of Sciences of the United States of America  2000 97:6202-6206  DOI:10.1073/pnas.97.11.6202  PMID:10823960
    • Reed, N. N., Janda, K. D. Stealth star polymers: A new high-loading scaffold for liquid-phase organic synthesis Organic Letters  2000 2:1311-1313  DOI:10.1021/ol005764y  PMID:10810735
    • Hasserodt, J., Janda, K. D., Lerner, R. A. A class of 4-aza-lithocholic acid-derived haptens for the generation of catalytic antibodies with steroid synthase capabilities Bioorganic & Medicinal Chemistry  2000 8:995-1003  DOI:10.1016/s0968-0896(00)00036-5  PMID:10882011
    • Harwig, C. W., Hoffman, T. Z., Wentworth, A. D., Janda, K. D. A one-pot multistep approach to alpha-azido-phosphonate and phosphonothioate diesters: Key intermediates in the synthesis of haptens for the generation of antibody ligases Bioorganic & Medicinal Chemistry Letters  2000 10:915-918  DOI:10.1016/s0960-894x(00)00137-2  PMID:10853659
    • Toker, J. D., Wentworth, P., Hu, Y. F., Houk, K. N., Janda, K. D. Antibody-catalysis of a bimolecular asymmetric 1,3-dipolar cycloaddition reaction Journal of the American Chemical Society  2000 122:3244-3245  DOI:10.1021/ja994423g
    • Wentworth, A. D., Wentworth, P., Mansoor, U. F., Janda, K. D. A soluble polymer-supported triflating reagent: A high-throughput synthetic approach to aryl and enol triflates Organic Letters  2000 2:477-480  DOI:10.1021/ol9913237  PMID:10814355
    • Hasserodt, J., Janda, K. D., Lerner, R. A. Antibodies mimic natural oxidosqualene-cyclase action in steroid ring a formation Journal of the American Chemical Society  2000 122:40-45  DOI:10.1021/ja993054l
    • Sieber, F., Wentworth, P., Janda, K. D. Exploiting poly(ethylene glycol) as a matrix for liquid-phase organic synthesis Molecules  2000 5:1018-1032  DOI:10.3390/50801018
    • Toy, P. H., Reger, T. S., Janda, K. D. Tailoring polystyrene solid-phase synthesis resins: Incorporation of flexible cross-linkers Aldrichimica Acta  2000 33:87-93
    • Lee, K. J., Angulo, A., Ghazal, P., Janda, K. D. Soluble-polymer supported synthesis of a prostanoid library: Identification of antiviral activity Organic Letters  1999 1:1859-1862  DOI:10.1021/ol991130j  PMID:10836045
    • Datta, A., Wentworth, P., Shaw, J. P., Simeonov, A., Janda, K. D. Catalytically distinct antibodies prepared by the reactive immunization versus transition state analogue hapten manifolds Journal of the American Chemical Society  1999 121:10461-10467  DOI:10.1021/ja991274t
    • Cordova, A., Reed, N. N., Ashley, J. A., Janda, K. D. Convenient synthesis of L-proline benzyl ester Bioorganic & Medicinal Chemistry Letters  1999 9:3119-3122  DOI:10.1016/s0960-894x(99)00546-6  PMID:10560736
    • Sieber, F., Wentworth, P., Janda, K. D. Exploring the scope of poly(ethylene glycol) (PEG) as a soluble polymer matrix for the stille cross-coupling reaction Journal of Combinatorial Chemistry  1999 1:540-546  DOI:10.1021/cc990052o  PMID:10748731
    • Brummer, O., Wentworth, P., Weiner, D. P., Janda, K. D. Phosphorodithioates: Synthesis and evaluation of new haptens for the generation of antibody acyl transferases Tetrahedron Letters  1999 40:7307-7310  DOI:10.1016/s0040-4039(99)01501-4
    • Wentworth, P., Janda, K. D. Liquid-phase chemistry: Recent advances in soluble polymer-supported catalysts, reagents and synthesis Chemical Communications  1999 1917-1924
    • Garibay, P., Toy, P. H., Hoeg-Jensen, T., Janda, K. D. Application of a new solid-phase resin: Benzamide ortho-lithiation and the synthesis of a phthalide library Synlett  1999 1438-1440
    • Brummer, O., Gao, C., Mao, S. L., Weiner, D. P., Janda, K. D. Design, synthesis and characterization of panning agents for the selection of metalloantibodies Letters in Peptide Science  1999 6:295-302  DOI:10.1007/bf02443425
    • Toy, P. H., Janda, K. D. New supports for solid-phase organic synthesis: Development of polystyrene resins containing tetrahydrofuran derived cross-linkers Tetrahedron Letters  1999 40:6329-6332  DOI:10.1016/s0040-4039(99)01251-4
    • Brummer, O., La Clair, J. J., Janda, K. D. A colorimetric ligand for mercuric ion Organic Letters  1999 1:415-418  DOI:10.1021/ol990730f
    • Gao, C., Brummer, O., Mao, S. L., Janda, K. D. Selection of human metalloantibodies from a combinatorial phage single-chain antibody library Journal of the American Chemical Society  1999 121:6517-6518  DOI:10.1021/ja990966e
    • Sieber, F., Wentworth, P., Toker, J. D., Wentworth, A. D., Metz, W. A., Reed, N. N., Janda, K. D. Development and application of a poly(ethylene glycol)-supported triarylphosphine reagent: Expanding the sphere of liquid-phase organic synthesis Journal of Organic Chemistry  1999 64:5188-5192  DOI:10.1021/jo9903712
    • Mao, S. L., Gao, C., Lo, C. H. L., Wirsching, P., Wong, C. H., Janda, K. D. Phage-display library selection of high-affinity human single-chain antibodies to tumor-associated carbohydrate antigens sialyl Lewis(x) and Lewis(x) Proceedings of the National Academy of Sciences of the United States of America  1999 96:6953-6958  DOI:10.1073/pnas.96.12.6953  PMID:10359820
    • Spivak, D. A., Hoffman, T. Z., Moore, A. H., Taylor, M. J., Janda, K. D. A comparison of flexible and constrained haptens in eliciting antibody catalysts for paraoxon hydrolysis Bioorganic & Medicinal Chemistry  1999 7:1145-1150  DOI:10.1016/s0968-0896(99)00026-7  PMID:10428386
    • Gao, C., Mao, S. L., Lo, C. H. L., Wirsching, P., Lerner, R. A., Janda, K. D. Making artificial antibodies: A format for phage display of combinatorial heterodimeric arrays Proceedings of the National Academy of Sciences of the United States of America  1999 96:6025-6030  DOI:10.1073/pnas.96.11.6025  PMID:10339535
    • Taylor, M. J., Yli-Kauhaluoma, J. T., Ashley, J. A., Wirsching, P., Lerner, R. A., Janda, K. D. The alpha-ketoamide group: A new motif for the elicitation of catalytic antibodies for acyl-transfer reactions Journal of the Chemical Society-Perkin Transactions 1  1999 1133-1134  DOI:10.1039/a902475a
    • Han, H. S., Cho, C. W., Janda, K. D. A substrate-based methodology that allows the regioselective control of the catalytic aminohydroxylation reaction Chemistry-a European Journal  1999 5:1565-1569  DOI:10.1002/(sici)1521-3765(19990503)5:5<1565::aid-chem1565>3.0.co;2-j
    • Berg, T., Simeonov, A., Janda, K. D. A combined parallel synthesis and screening of macrocyclic lanthanide complexes for the cleavage of phospho di- and triesters and double-stranded DNA Journal of Combinatorial Chemistry  1999 1:96-100  DOI:10.1021/cc9800125  PMID:10746017
    • Janda, K. D., Wentworth, A. D. A merging of chemistry and biology in terms of antibody catalysis Phosphorus Sulfur and Silicon and the Related Elements  1999 146:117-120
    • Wentworth, P., Janda, K. D. Antibody catalysis of phosphodiester hydrolysis: A survey of hapten strategies Phosphorus Sulfur and Silicon and the Related Elements  1999 146:247-250
    • Han, H., Yoon, J., Janda, K. D. Azatides as peptidomimetics: solution and liquid phase syntheses Methods in Molecular Medicine  1999 23:87-102  DOI:10.1385/0-89603-517-4:87  PMID:21380893
    • Paschall, C. M., Hasserodt, J., Jones, T., Lerner, R. A., Janda, K. D., Christianson, D. W. Convergence of catalytic antibody and terpene cyclase mechanisms: Polyene cyclization directed by carbocation - pi-interactions Angewandte Chemie-International Edition  1999 38:1743-1747  DOI:10.1002/(sici)1521-3773(19990614)38:12<1743::aid-anie1743>3.0.co;2-3
    • Ashley, J. A., Wirsching, P., Janda, K. D., Lin, C. H. Monitoring chemical warfare agents: A new method for the detection of methylphosphonic acid Angewandte Chemie-International Edition  1999 38:1793-1795  DOI:10.1002/(sici)1521-3773(19990614)38:12<1793::aid-anie1793>3.3.co;2-l
    • Yoon, J. Y., Cho, C. W., Han, H., Janda, K. D. Solution and soluble polymer synthesis of 3-aminoimidazoline-2,4-diones Chemical Communications  1998 2703-2704  DOI:10.1039/a807067i
    • Taylor, M. J., Hoffman, T. Z., Yli-Kauhaluoma, J. T., Lerner, R. A., Janda, K. D. A light-activated antibody catalyst Journal of the American Chemical Society  1998 120:12783-12790  DOI:10.1021/ja982711r
    • Zhao, X. Y., Metz, W. A., Sieber, F., Janda, K. D. Expanding on the purification methodology of polyethylene glycol (PEG) bound molecules: The synthesis of 3,5-pyrazolidinediones Tetrahedron Letters  1998 39:8433-8436  DOI:10.1016/s0040-4039(98)01921-2
    • Gravert, D. J., Datta, A., Wentworth, P., Janda, K. D. Soluble supports tailored for organic synthesis: Parallel polymer synthesis via sequential normal/living free radical processes Journal of the American Chemical Society  1998 120:9481-9495  DOI:10.1021/ja980241v
    • Zhao, X., Janda, K. D. Soluble polymer traceless linker investigations: Solvent effects on the desulfonylation of polyethylene glycol (PEG) substituted aryl alkyl sulfones with sodium amalgam Bioorganic & Medicinal Chemistry Letters  1998 8:2439-2442  DOI:10.1016/s0960-894x(98)00441-7  PMID:9873557
    • Hori, M., Gravert, D. J., Wentworth, P., Janda, K. D. Investigating highly crosslinked macroporous resins for solid-phase synthesis Bioorganic & Medicinal Chemistry Letters  1998 8:2363-2368  DOI:10.1016/s0960-894x(98)00427-2  PMID:9873542
    • Chen, S. Q., Janda, K. D. Total synthesis of naturally occurring prostaglandin F2 alpha on a non-cross-linked polystyrene support Tetrahedron Letters  1998 39:3943-3946  DOI:10.1016/s0040-4039(98)00729-1
    • Wentworth, P., Liu, Y. Q., Wentworth, A. D., Fan, P., Foley, M. J., Janda, K. D. A bait and switch hapten strategy generates catalytic antibodies for phosphodiester hydrolysis Proceedings of the National Academy of Sciences of the United States of America  1998 95:5971-5975  DOI:10.1073/pnas.95.11.5971  PMID:9600901
    • Berg, T., Vandersteen, A. M., Janda, K. D. High-throughput synthesis and direct screening for the discovery of novel hydrolytic metal complexes Bioorganic & Medicinal Chemistry Letters  1998 8:1221-1224  DOI:10.1016/s0960-894x(98)00199-1  PMID:9871739
    • Yli-Kauhaluoma, J. T., Harwig, C. W., Wentworth, P., Janda, K. D. Unexpected 1,3-oxazolidine formation in the attempted oxidation of N-aryl-N-methyl substituted beta-amino alcohols using pyridinium dichromate Tetrahedron Letters  1998 39:2269-2272  DOI:10.1016/s0040-4039(98)00289-5
    • Heine, A., Stura, E. A., Yli-Kauhaluoma, J. T., Gao, C., Deng, Q. L., Beno, B. R., Houk, K. N., Janda, K. D., Wilson, I. A. An antibody exo Diels-Alderase inhibitor complex at 1.95 Å resolution Science  1998 279:1934-1940  DOI:10.1126/science.279.5358.1934  PMID:9506943
    • Han, H. S., Yoon, J., Janda, K. D. An efficient asymmetric route to 2,3-diaminobutanoic acids Journal of Organic Chemistry  1998 63:2045-2048  DOI:10.1021/jo9720391
    • Gravert, D. J., Janda, K. D. Bifunctional initiators for free radical polymerization of non-crosslinked block copolymers Tetrahedron Letters  1998 39:1513-1516  DOI:10.1016/s0040-4039(98)00070-7
    • Gao, C., Lavey, B. J., Lo, C. H. L., Datta, A., Wentworth, P., Janda, K. D. Direct selection for catalysis from combinatorial antibody libraries using a boronic acid probe: Primary amide bond hydrolysis Journal of the American Chemical Society  1998 120:2211-2217  DOI:10.1021/ja9720220
    • Wentworth, P., Janda, K. D. Catalytic antibodies Current Opinion in Chemical Biology  1998 2:138-144  DOI:10.1016/s1367-5931(98)80046-x  PMID:9667908
    • Wentworth, P., Janda, K. D. Generating and analyzing combinatorial chemistry libraries Current Opinion in Biotechnology  1998 9:109-115  DOI:10.1016/s0958-1669(98)80093-1
    • Han, H., Yoon, J., Janda, K. D. Investigations of azapeptides as mimetics of Leu-enkephalin Bioorganic & Medicinal Chemistry Letters  1998 8:117-120  DOI:10.1016/s0960-894x(97)10198-6  PMID:9871637
    • Hoffman, T. Z., Xie, Y. L., Wirsching, P., Janda, K. D., Lin, C. H. An antibody transesterase derived from reactive immunization that utilizes a wide variety of alcohol substrates Chemical Communications  1998 1075-1076  DOI:10.1039/a801569d
    • Lerner, R. A., Barbas, C. F., Janda, K. D. Making enzymes Harvey Lectures  1998 92:1-40  PMID:15372741
    • Gao, C., Lo, C. H. L., Mao, S., Wirsching, P., Lerner, R. A., Janda, K. D., Lin, C. H. Making chemistry selectable by linking it to infectivity Proceedings of the National Academy of Sciences of the United States of America  1997 94:11777-11782  DOI:10.1073/pnas.94.22.11777  PMID:9342313
    • Lo, C. H. L., Wentworth, P., Jung, K. W., Yoon, J., Ashley, J. A., Janda, K. D. Reactive immunization strategy generates antibodies with high catalytic proficiencies Journal of the American Chemical Society  1997 119:10251-10252  DOI:10.1021/ja971442m
    • Chen, S. Q., Janda, K. D. Synthesis of prostaglandin E-2 methyl ester on a soluble-polymer support for the construction of prostanoid libraries Journal of the American Chemical Society  1997 119:8724-8725  DOI:10.1021/ja971634h
    • Hasserodt, J., Janda, K. D. Syntheses of octahydroquinoline-N-oxides: Haptens designed to elicit catalytic antibodies that control a terpenoid-like cascade cyclisation Tetrahedron  1997 53:11237-11256  DOI:10.1016/s0040-4020(97)00715-1
    • Zhao, X. Y., Janda, K. D. Syntheses of alkylated malonates on a traceless linker derived soluble polymer support Tetrahedron Letters  1997 38:5437-5440  DOI:10.1016/s0040-4039(97)01216-1
    • Hasserodt, J., Janda, K. D., Lerner, R. A. Formation of bridge-methylated decalins by antibody-catalyzed tandem cationic cyclization Journal of the American Chemical Society  1997 119:5993-5998  DOI:10.1021/ja970675a
    • Gravert, D. J., Janda, K. D. Synthesis on soluble polymers: New reactions and the construction of small molecules Current Opinion in Chemical Biology  1997 1:107-113  DOI:10.1016/s1367-5931(97)80116-0  PMID:9667833
    • Jung, K. W., Zhao, X. Y., Janda, K. D. Development of new linkers for the formation of aliphatic C-H bonds on polymeric supports Tetrahedron  1997 53:6645-6652  DOI:10.1016/s0040-4020(97)00222-6
    • Wentworth, P., Janda, K. D. Synthesis of oxorhenium(V) and oxotechnetium(V) complexes as inhibitors of ribonucleases and for the generation of catalytic antibodies Synlett  1997 537-543
    • Weiner, D. P., Wiemann, T., Wolfe, M. M., Wentworth, P., Janda, K. D. A pentacoordinate oxorhenium(V) metallochelate elicits antibody catalysts for phosphodiester cleavage Journal of the American Chemical Society  1997 119:4088-4089  DOI:10.1021/ja970107v
    • Wentworth, P., Vandersteen, A. M., Janda, K. D. Poly(ethylene glycol) (PEG) as a reagent support: The preparation and utility of a PEG-triarylphosphine conjugate in liquid-phase organic synthesis (LPOS) Chemical Communications  1997 759-760
    • Han, H. S., Janda, K. D. A soluble polymer-bound approach to the sharpless catalytic asymmetric dihydroxylation (AD) reaction: Preparation and application of a (DHQD)(2)PHAL-PEG-OMe ligand Tetrahedron Letters  1997 38:1527-1530  DOI:10.1016/s0040-4039(97)00129-9
    • Li, T. Y., Lerner, R. A., Janda, K. D. Antibody-catalyzed cationic reactions: Rerouting of chemical transformations via antibody catalysis Accounts of Chemical Research  1997 30:115-121  DOI:10.1021/ar960172u
    • Gravert, D. J., Janda, K. D. Organic synthesis on soluble polymer supports: Liquid-phase methodologies Chemical Reviews  1997 97:489-509  DOI:10.1021/cr960064l  PMID:11848880
    • Janda, K. D., Lo, L. C., Lo, C. H. L., Sim, M. M., Wang, R., Wong, C. H., Lerner, R. A. Chemical selection for catalysis in combinatorial antibody libraries Science  1997 275:945-948  DOI:10.1126/science.275.5302.945  PMID:9020070
    • Zhao, X. Y., Jung, K. W., Janda, K. D. Soluble polymer synthesis: An improved traceless linker methodology for aliphatic C-H bond formation Tetrahedron Letters  1997 38:977-980  DOI:10.1016/s0040-4039(96)02503-8
    • Han, H., Janda, K. D. Multipolymer-supported substrate and ligand approach to the sharpless asymmetric dihydroxylation Angewandte Chemie-International Edition  1997 36:1731-1733  DOI:10.1002/anie.199717311
    • Hoffman, T. Z., Wirsching, P., Barbas, C. F., Janda, K. D., Lerner, R. A., Lin, C. H. On roads not taken in the evolution of protein catalysts: Antibody steroid isomerases that use an enamine mechanism Proceedings of the National Academy of Sciences of the United States of America  1997 94:11773-11776  DOI:10.1073/pnas.94.22.11773  PMID:9342312
    • Wentworth, P., Wiemann, T., Janda, K. D. A new class of pentacoordinate ribonuclease inhibitors: Synthesis, characterization, and inhibition studies of ribonucleoside and anhydropentofuranose oxorhenium(V) complexes Journal of the American Chemical Society  1996 118:12521-12527  DOI:10.1021/ja9611248
    • Hasserodt, J., Janda, K. D., Lerner, R. A. Antibody catalyzed terpenoid cyclization Journal of the American Chemical Society  1996 118:11654-11655  DOI:10.1021/ja954316w
    • Lavey, B. J., Janda, K. D. Catalytic antibody mediated hydrolysis of paraoxon Journal of Organic Chemistry  1996 61:7633-7636  DOI:10.1021/jo960629d  PMID:11667704
    • Jung, K. W., Janda, K. D., Sanfilippo, P. J., Wachter, M. Syntheses and biological evaluation of two new naproxen analogs Bioorganic & Medicinal Chemistry Letters  1996 6:2281-2282
    • Vandersteen, A. M., Han, H., Janda, K. D. Liquid-phase combinatorial synthesis: In search of small-molecule enzyme mimics Molecular Diversity  1996 2:89-96  DOI:10.1007/bf01718705  PMID:9238638
    • Vandersteen, A. M., Janda, K. D. A re-examination of two linear pentapeptides claimed to be serine protease mimics Journal of the American Chemical Society  1996 118:8787-8790  DOI:10.1021/ja9616140
    • Wentworth, P., Janda, K. D. A facile and efficient route to 3',5'-diamino-3',5'-dideoxynucleosides Chemical Communications  1996 2097-2098  DOI:10.1039/cc9960002097
    • Lo, L. C., Lo, C. H. L., Janda, K. D., Kassel, D. B., Raushel, F. M. A versatile mechanism based reaction probe for the direct selection of biocatalysts Bioorganic & Medicinal Chemistry Letters  1996 6:2117-2120  DOI:10.1016/0960-894x(96)00379-4
    • Jung, K. W., Zhao, X. Y., Janda, K. D. A linker that allows efficient formation of aliphatic C-H bonds on polymeric supports Tetrahedron Letters  1996 37:6491-6494  DOI:10.1016/0040-4039(96)01419-0
    • Han, H. S., Janda, K. D. Soluble polymer-bound ligand-accelerated catalysis: Asymmetric dihydroxylation Journal of the American Chemical Society  1996 118:7632-7633  DOI:10.1021/ja9608095
    • Sakurai, M., Wirsching, P., Janda, K. D. Design and synthesis of a cocaine-diamide hapten for vaccine development Tetrahedron Letters  1996 37:5479-5482  DOI:10.1016/0040-4039(96)01170-7
    • Lavey, B. J., Janda, K. D. Antibody catalyzed hydrolysis of a phosphotriester Bioorganic & Medicinal Chemistry Letters  1996 6:1523-1524  DOI:10.1016/s0960-894x(96)00266-1
    • Sakurai, M., Wirsching, P., Janda, K. D. Synthesis of a nucleoside hapten with a P(O)-O-N linkage to elicit catalytic antibodies with phosphodiesterase activity Bioorganic & Medicinal Chemistry Letters  1996 6:1055-1060  DOI:10.1016/0960-894x(96)00169-2
    • Han, H., Janda, K. D. Azatides: Solution and liquid phase syntheses of a new peptidomimetic Journal of the American Chemical Society  1996 118:2539-2544  DOI:10.1021/ja9535470
    • Li, T. G., Janda, K. D., Lerner, R. A. Cationic cyclopropanation by antibody catalysis Nature  1996 379:326-327  PMID:8552185
    • Yli-Kauhaluoma, J. T., Ashley, J. A., Lo, C. H. L., Coakley, J., Wirsching, P., Janda, K. D. Catalytic antibodies with peptidyl-prolyl cis-trans isomerase activity Journal of the American Chemical Society  1996 118:5496-5497  DOI:10.1021/ja954206p
    • Lo, C. H. L., Gao, C., Mao, S. L., Matsui, K., Lerner, R. A., Janda, K. D. Chain shuffling: Investigations into the specificity and selectivity of antibody catalysis Israel Journal of Chemistry  1996 36:195-198
    • Janda, K. D., Han, H. S. Combinatorial chemistry: A liquid-phase approach Combinatorial Chemistry  1996 267:234-247  PMID:8743320
    • Wirsching, P., Ashley, J. A., Lo, C. H. L., Janda, K. D., Lerner, R. A. Reactive immunization Science  1995 270:1775-1782  DOI:10.1126/science.270.5243.1775  PMID:8525366
    • Carrera, M. R. A., Ashley, J. A., Parsons, L. H., Wirsching, P., Koob, G. F., Janda, K. D. Suppression of psychoactive effects of cocaine by active immunization Nature  1995 378:727-730  DOI:10.1038/378727a0  PMID:7501020
    • Li, T. Y., Janda, K. D. Synthesis of a bifunctional hapten designed to mimic both transition-state and to induce bait and switch catalysis Bioorganic & Medicinal Chemistry Letters  1995 5:2001-2004  DOI:10.1016/0960-894x(95)00341-p
    • Han, H. S., Wolfe, M. M., Brenner, S., Janda, K. D. Liquid-phase combinatorial synthesis Proceedings of the National Academy of Sciences of the United States of America  1995 92:6419-6423  DOI:10.1073/pnas.92.14.6419  PMID:7541541  PMCID:PMC41529
    • Li, T. Y., Hilton, S., Janda, K. D. Remarkable ability of different antibody catalysts to control and diversify the product outcome of cationic cyclization reactions Journal of the American Chemical Society  1995 117:3308-3309  DOI:10.1021/ja00116a050
    • Fenniri, H., Janda, K. D., Lerner, R. A. Encoded reaction cassette for the highly sensitive detection of the making and breaking of chemical-bonds Proceedings of the National Academy of Sciences of the United States of America  1995 92:2278-2282  DOI:10.1073/pnas.92.6.2278  PMID:7892261
    • Janda, K. D., Shevlin, C. G., Lerner, R. A. Oxepane synthesis along a disfavored pathway - the rerouting of a chemical-reaction using a catalytic antibody Journal of the American Chemical Society  1995 117:2659-2660  DOI:10.1021/ja00114a035
    • Li, T. Y., Janda, K. D., Hilton, S., Lerner, R. A. An antibody-catalyzed nucleophilic-substitution reaction at a primary carbon that appears to proceed by an ionization mechanism Journal of the American Chemical Society  1995 117:2367-2368  DOI:10.1021/ja00113a033
    • Li, T. Y., Hilton, S., Janda, K. D. The potential application of catalytic antibodies to protecting group removal - catalytic antibodies with broad substrate tolerance Journal of the American Chemical Society  1995 117:2123-2127  DOI:10.1021/ja00113a001
    • Yli-Kauhaluoma, J. T., Ashley, J. A., Lo, C. H., Tucker, L., Wolfe, M. M., Janda, K. D. Anti-metallocene antibodies: A new approach to enantioselective catalysis of the Diels-Alder reaction Journal of the American Chemical Society  1995 117:7041-7047  DOI:10.1021/ja00132a001
    • Rosenblum, J. S., Lo, L. C., Li, T. Y., Janda, K. D., Lerner, R. A. Antibody-catalyzed phosphate triester hydrolysis Angewandte Chemie-International Edition  1995 34:2275-2277  DOI:10.1002/anie.199522751
    • Erb, E., Janda, K. D., Brenner, S. Recursive deconvolution of combinatorial chemical libraries Proceedings of the National Academy of Sciences of the United States of America  1994 91:11422-11426  DOI:10.1073/pnas.91.24.11422  PMID:7972077  PMCID:PMC45243
    • Janda, K. D. Tagged versus untagged libraries - methods for the generation and screening of combinatorial chemical libraries Proceedings of the National Academy of Sciences of the United States of America  1994 91:10779-10785  DOI:10.1073/pnas.91.23.10779  PMID:7971962
    • Cravatt, B. F., Ashley, J. A., Janda, K. D., Boger, D. L., Lerner, R. A. Crossing extreme mechanistic barriers by antibody catalysis: Syn elimination to a cis olefin Journal of the American Chemical Society  1994 116:6013-6014  DOI:10.1021/ja00092a080
    • Li, T. Y., Janda, K. D., Ashley, J. A., Lerner, R. A. Antibody-catalyzed cationic cyclization Science  1994 264:1289-1293  DOI:10.1126/science.8191282  PMID:8191282
    • Janda, K. D. Catalytic antibodies and enzyme-inhibitors Pure and Applied Chemistry  1994 66:703-708  DOI:10.1351/pac199466040703
    • Janda, K. D.*, Lo, C. H. L.*, Li, T. Y., Barbas, C. F., Wirsching, P., Lerner, R. A. Direct selection for a catalytic mechanism from combinatorial antibody libraries Proceedings of the National Academy of Sciences of the United States of America  1994 91:2532-2536  DOI:10.1073/pnas.91.7.2532  PMID:8146149 (* = equal contribution)
    • Shevlin, C. G., Hilton, S., Janda, K. D. Automation of antibody catalysis - a practical methodology for the use of catalytic antibodies in organic-synthesis Bioorganic & Medicinal Chemistry Letters  1994 4:297-302  DOI:10.1016/s0960-894x(01)80132-3
    • Yli-Kauhaluoma, J. T., Janda, K. D. An expedient synthesis of isopropyl anisoles and veratroles Tetrahedron Letters  1994 35:4509-4510  DOI:10.1016/s0040-4039(00)60713-x
    • Janda, K. D. Catalytic antibodies - the rerouting of chemical-reactions Biochemical Society Transactions  1993 21:1090-1095  PMID:8131905
    • Nielsen, J., Brenner, S., Janda, K. D. Synthetic methods for the implementation of encoded combinatorial chemistry Journal of the American Chemical Society  1993 115:9812-9813  DOI:10.1021/ja00074a063
    • Gouverneur, V. E., Houk, K. N., Depascualteresa, B., Beno, B., Janda, K. D., Lerner, R. A. Control of the exo-pathway and endo-pathway of the Diels-Alder reaction by antibody catalysis Science  1993 262:204-208  DOI:10.1126/science.8211138  PMID:8211138
    • Na, J., Houk, K. N., Shevlin, C. G., Janda, K. D., Lerner, R. A. The energetic advantage of 5-exo versus 6-endo epoxide openings - a preference overwhelmed by antibody catalysis Journal of the American Chemical Society  1993 115:8453-8454  DOI:10.1021/ja00071a067
    • Wade, W. S., Ashley, J. A., Jahangiri, G. K., McElhaney, G., Janda, K. D., Lerner, R. A. A highly specific metal-activated catalytic antibody Journal of the American Chemical Society  1993 115:4906-4907  DOI:10.1021/ja00064a068
    • Ikeda, S., Janda, K. D. Recent development on the research of catalytic antibodies and their applications Journal of Synthetic Organic Chemistry Japan  1993 51:284-297
    • Ashley, J. A., Lo, C. H. L., McElhaney, G. P., Wirsching, P., Janda, K. D. A catalytic antibody model for plp-dependent decarboxylases Journal of the American Chemical Society  1993 115:2515-2516  DOI:10.1021/ja00059a061
    • Janda, K. D., Shevlin, C. G., Lerner, R. A. Antibody catalysis of a disfavored chemical transformation Science  1993 259:490-493  DOI:10.1126/science.8424171
    • Chen, Y. C. J., Danon, T., Sastry, L., Mubaraki, M., Janda, K. D., Lerner, R. A. Catalytic antibodies from combinatorial libraries Journal of the American Chemical Society  1993 115:357-358  DOI:10.1021/ja00054a058
    • Weinhouse, M. I., Janda, K. D. A new methodology for the preparation of vinyl esters Synthesis-Stuttgart  1993 81-83
    • Ashley, J. A., Janda, K. D. Antibody catalysis in low water content media Journal of Organic Chemistry  1992 57:6691-6693  DOI:10.1021/jo00051a003
    • Ikeda, S., Ashley, J. A., Wirsching, P., Janda, K. D. Psi PO2-CH2N+ , a new amide bond replacement - potent, slow-binding inhibition of the HIV protease Journal of the American Chemical Society  1992 114:7604-7606  DOI:10.1021/ja00045a067
    • Fernholz, E., Schloeder, D., Liu, K. K. C., Bradshaw, C. W., Huang, H. M., Janda, K., Lerner, R. A., Wong, C. H. Specificity of antibody-catalyzed transesterifications using enol esters - a comparison with lipase reactions Journal of Organic Chemistry  1992 57:4756-4761  DOI:10.1021/jo00043a042
    • Gibbs, R. A., Benkovic, P. A., Janda, K. D., Lerner, R. A., Benkovic, S. J. Substituent effects on an antibody-catalyzed hydrolysis of phenyl-esters - further evidence for an acyl-antibody intermediate Journal of the American Chemical Society  1992 114:3528-3534  DOI:10.1021/ja00035a057
    • Reymond, J. L., Janda, K. D., Lerner, R. A. Highly enantioselective protonation catalyzed by an antibody Journal of the American Chemical Society  1992 114:2257-2258  DOI:10.1021/ja00032a050
    • Chen, Y. C. J., Janda, K. D. A new approach toward the inhibition of ribonucleases - a water-stable ribonucleoside technetium chelate Journal of the American Chemical Society  1992 114:1488-1489  DOI:10.1021/ja00030a058
    • Fujii, I., Lerner, R. A., Janda, K. D. Enantiofacial protonation by catalytic antibodies Journal of the American Chemical Society  1991 113:8528-8529  DOI:10.1021/ja00022a054
    • Ikeda, S., Weinhouse, M. I., Janda, K. D., Lerner, R. A., Danishefsky, S. J. Asymmetric induction via a catalytic antibody Journal of the American Chemical Society  1991 113:7763-7764  DOI:10.1021/ja00020a049
    • Hein, M. B., Tang, Y., McLeod, D. A., Janda, K. D., Hiatt, A. Evaluation of immunoglobulins from plant-cells Biotechnology Progress  1991 7:455-461  DOI:10.1021/bp00011a011  PMID:1367994
    • Janda, K. D., Weinhouse, M. I., Danon, T., Pacelli, K. A., Schloeder, D. M. Antibody bait and switch catalysis - a survey of antigens capable of inducing abzymes with acyl-transfer properties Journal of the American Chemical Society  1991 113:5427-5434  DOI:10.1021/ja00014a039
    • Chen, Y. C. J., Hansske, F., Janda, K. D., Robins, M. J. Nucleic-acid related-compounds .64. Synthesis of 2',3'-diazido-2',3'-dideoxyadenosine and 2',3'-diamino-2',3'-dideoxyadenosine from 9-(Beta-D-Arabinofuranosyl)adenine Journal of Organic Chemistry  1991 56:3410-3413  DOI:10.1021/jo00010a042
    • Wirsching, P., Ashley, J. A., Benkovic, S. J., Janda, K. D., Lerner, R. A. An unexpectedly efficient catalytic antibody operating by ping-pong and induced fit mechanisms Science  1991 252:680-685  DOI:10.1126/science.2024120  PMID:2024120
    • Kang, A. S., Barbas, C. F., Janda, K. D., Benkovic, S. J., Lerner, R. A. Linkage of recognition and replication functions by assembling combinatorial antibody Fab libraries along phage surfaces Proceedings of the National Academy of Sciences of the United States of America  1991 88:4363-4366  DOI:10.1073/pnas.88.10.4363  PMID:1903540
    • Janda, K. D., Benkovic, S. J., McLeod, D. A., Schloeder, D. M., Lerner, R. A. Substrate attenuation - an approach to improve antibody catalysis Tetrahedron  1991 47:2503-2506  DOI:10.1016/s0040-4020(01)81784-1
    • Janda, K. D., Ashley, J. A., Jones, T. M., McLeod, D. A., Schloeder, D. M., Weinhouse, M. I., Lerner, R. A., Gibbs, R. A., Benkovic, P. A., Hilhorst, R., Benkovic, S. J. Catalytic antibodies with acyl-transfer capabilities - mechanistic and kinetic investigations Journal of the American Chemical Society  1991 113:291-297  DOI:10.1021/ja00001a042
    • Benkovic, S. J., Adams, J., Janda, K. D., Lerner, R. A. A catalytic antibody uses a multistep kinetic sequence Ciba Foundation Symposia  1991 159:4-12  PMID:1959451
    • Reymond, J. L., Janda, K. D., Lerner, R. A. Antibody catalysis of glycosidic bond hydrolysis Angewandte Chemie-International Edition  1991 30:1711-1713  DOI:10.1002/anie.199117111
    • McLeod, D. A., Brinkworth, R. I., Ashley, J. A., Janda, K. D., Wirsching, P. Phosphonamidates and phosphonamidate esters as HIV-1 protease inhibitors Bioorganic & Medicinal Chemistry Letters  1991 1:653-658  DOI:10.1016/s0960-894x(01)81171-9
    • Sastry, L., Mubaraki, M., Janda, K. D., Benkovic, S. J., Lerner, R. A. Screening combinatorial antibody libraries for catalytic acyl transfer-reactions Ciba Foundation Symposia  1991 159:145-155  PMID:1835693
    • Benkovic, S. J., Adams, J. A., Borders, C. L., Janda, K. D., Lerner, R. A. The enzymatic nature of antibody catalysis - development of multistep kinetic processing Science  1990 250:1135-1139  DOI:10.1126/science.2251500  PMID:2251500
    • Janda, K. D., Ashley, J. A., Jones, T. M., McLeod, D. A., Schloeder, D. M., Weinhouse, M. I. Immobilized catalytic antibodies in aqueous and organic-solvents Journal of the American Chemical Society  1990 112:8886-8888  DOI:10.1021/ja00180a035
    • Janda, K. D. New strategies for the design of catalytic antibodies Biotechnology Progress  1990 6:178-181  DOI:10.1021/bp00003a002  PMID:1366610
    • Janda, K. D., Weinhouse, M. I., Schloeder, D. M., Lerner, R. A., Benkovic, S. J. Bait and switch strategy for obtaining catalytic antibodies with acyl-transfer capabilities Journal of the American Chemical Society  1990 112:1274-1275  DOI:10.1021/ja00159a074
    • Janda, K. D., Ashley, J. A. Syntheses of the saturated analogs of 4-nitrophenol and 4-nitroaniline Synthetic Communications  1990 20:1073-1082  DOI:10.1080/00397919008052811
    • Sastry, L., Altingmees, M., Huse, W. D., Short, J. M., Sorge, J. A., Hay, B. N., Janda, K. D., Benkovic, S. J., Lerner, R. A. Cloning of the immunological repertoire in escherichia-coli for generation of monoclonal catalytic antibodies - construction of a heavy-chain variable region-specific cDNA library Proceedings of the National Academy of Sciences of the United States of America  1989 86:5728-5732  DOI:10.1073/pnas.86.15.5728  PMID:2503822
    • Janda, K. D., Benkovic, S. J., Lerner, R. A. Catalytic antibodies with lipase activity and R-substrate or S-substrate selectivity Science  1989 244:437-440  DOI:10.1126/science.2717936  PMID:2717936
    • Janda, K. D., Schloeder, D., Benkovic, S. J., Lerner, R. A. Induction of an antibody that catalyzes the hydrolysis of an amide bond Science  1988 241:1188-1191  DOI:10.1126/science.3413482  PMID:3413482
    • Janda, K. D., Lerner, R. A., Tramontano, A. Antibody catalysis of bimolecular amide formation Journal of the American Chemical Society  1988 110:4835-4837  DOI:10.1021/ja00222a056
    • Tramontano, A., Kang, A. S., Janda, K., Napper, A. D., Benkovic, S. J., Lerner, R. A. Catalytic antibodies Cold Spring Harbor Symposia on Quantitative Biology  1987 52:91-96  PMID:3454298
    • Tramontano, A., Janda, K. D., Lerner, R. A. Catalytic antibodies Science  1986 234:1566-1570  DOI:10.1126/science.3787261  PMID:3787261
    • Tramontano, A., Janda, K. D., Lerner, R. A. Chemical-reactivity at an antibody-binding site elicited by mechanistic design of a synthetic antigen Proceedings of the National Academy of Sciences of the United States of America  1986 83:6736-6740  DOI:10.1073/pnas.83.18.6736  PMID:3462723
    • Bates, R. B., Janda, K. D., Wright, M. E. N-Isobutyrylbenzamide, C11H13NO2 Acta Crystallographica Section C-Crystal Structure Communications  1985 41:263-264  DOI:10.1107/s0108270185003559
    • Bates, R. B., Janda, K. D. A convenient synthesis of alpha-acylamino alcohols from azlactones Synthesis-Stuttgart  1984 310-311
    • Bates, R. B., Fletcher, F. A., Janda, K. D., Miller, W. A. A convenient synthesis of unsymmetrical acyclic imides Journal of Organic Chemistry  1984 49:3038-3038  DOI:10.1021/jo00190a039
    • Bates, R. B., Gin, S. L., Hassen, M. A., Hruby, V. J., Janda, K. D., Kriek, G. R., Michaud, J. P., Vine, D. B. Synthesis of cyclo-N-methyl-L-tyr-N-methyl-L-tyr-D-ala-L-ala-O,N-dimethyl-L-tyr-L-ala, a cyclic hexapeptide related to the antitumor agent deoxybouvardin Heterocycles  1984 22:785-790  DOI:10.3987/R-1984-04-0785
    • Janda, K. D., McConnell, W. W., Nelson, G. O., Wright, M. E. Preparation and reactivity of the new cyclopentadienyl-bridged complex (Me2SICH2CH2SIME2)(C5H4Fe(CO)2)2 Journal of Organometallic Chemistry  1983 259:139-143  DOI:10.1016/0022-328x(83)87157-5
    • Bates, R. B., Janda, K. D. High-yield benzyne synthesis of diaryl ethers Journal of Organic Chemistry  1982 47:4374-4376  DOI:10.1021/jo00143a051

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Affiliation

head of

  • The Worm Institute for Research and Medicine (WIRM) Director
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Research

research overview

  • Merging of Chemistry and Biology

    Our work encompasses the following areas: the development of methods for the detection of and protection against chemical/biological warfare agents, the preparation of combinatorial chemical libraries, the design/synthesis and evaluation of catalytic antibodies and enzyme inhibitors, solid-phase organic synthesis, antibody/peptide phage display libraries, the application of immunopharmacotherapy in the treatment of drug addiction and cancer, methods of prevention and treatment of obesity, diagnostic and therapeutic strategies towards neglected tropical diseases, and investigation and development of molecules that block quorum sensing in bacteria.

keywords

  • metabolomics
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Teaching

advisees

  • graduate advising relationship

    • Lin, Lucy, Ph.D.  candidate, 2017 -
    • Shirey, Ryan, Ph.D.  candidate, 2017 -
    • Smith, Lauren, Ph.D.  candidate, 2016 -
    • Jacob, Nicholas Taylor, Ph.D.  candidate, 2014 - 2018
    • Xue, Song, Ph.D.  candidate, 2014 - 2018
    • Bremer, Paul, Ph.D.  candidate, 2012 - 2016
    • Moreno, Amira, Ph.D.  candidate, 2007 - 2012
    • Rohrbach, Amanda, Ph.D.  candidate, 2007 - 2012
    • Treweek, Jennifer, Ph.D.  candidate, 2006 - 2011
    • Lowery, Colin, Ph.D.  candidate, 2005 - 2010
    • Boldt, Grant E, Ph.D.  candidate, 2005 - 2007
    • Xu, Yang, Ph.D.  candidate, 2002 - 2007
    • Kaufmann, Gunnar, Ph.D.  candidate, 2002 - 2006
    • Kim, YoungSoo, Ph.D.  candidate, 2003 - 2006
    • Carrera, M. Rocio Alberro, Ph.D.  candidate, 2002 - 2005
    • Moss, Jason, Ph.D.  candidate, 2001 - 2005
    • Dickerson, Tobin, Ph.D.  candidate, 2001 - 2004
    • Gao, Changshou, Ph.D.  candidate, 1995 - 2002
    • Toker, Jonathan, Ph.D.  candidate, 1997 - 2001
    • Lo, Chih-Hung Larry, Ph.D.  candidate, 1991 - 1995
  • postdoc or fellow advising relationship

    • Bremer, Paul, Ph.D.  candidate, 2016 - 2017
    • Lockner, Jonathan, Ph.D.  candidate, 2011 - 2015
    • Dickerson, Tobin, Ph.D.  candidate, 2004 - 2005
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Background

education and training

  • Ph.D. in Organic & Medicinal Chemistry, The University of Arizona 1984
  • M.S. in Organic Chemistry, The University of Arizona 1983
  • B.S. in Clinical Chemistry, University of South Florida 1980

awards and honors

  • Fellow of the American Academy of Arts and Sciences, conferred by American Academy of Arts & Sciences, 2002
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Contact

full name

  • Kim D. Janda

geographic location

  • Scripps California 
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Identity

ORCID iD

  • ORCID iD http://orcid.org/0000-0001-6759-4227

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