recent publications
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academic article
- Belz, T. F., Bremer, P. T., Zhou, B., Blake, S., Ellis, B., Eubanks, L. M., Janda, K. D. Sulfonate-isosteric replacement examined within heroin-hapten vaccine design Bioorganic & Medicinal Chemistry Letters 2020 30 DOI:10.1016/j.bmcl.2020.127388 PMID:32738981 PMCID:PMC7398700
- Belz, T. F., Bremer, P. T., Zhou, B., Ellis, B., Eubanks, L. M., Janda, K. D. Enhancement of a Heroin Vaccine through Hapten Deuteration Journal of the American Chemical Society 2020 142:13294-13298 DOI:10.1021/jacs.0c05219 PMID:32700530
- Blake, S., Thanissery, R., Rivera, A. J., Hixon, M. S., Lin, M., Theriot, C. M., Janda, K. D. Salicylanilide Analog Minimizes Relapse of Clostridioides difficile Infection in Mice Journal of Medicinal Chemistry 2020 63:6898-6908 DOI:10.1021/acs.jmedchem.0c00123 PMID:32482070
- Wang, J., Ellis, B., Zhou, B., Eubanks, L. M., Blake, S., Janda, K. D. A fentanyl vaccine constructed upon opsonizing antibodies specific for the Gal alpha 1-3Gal epitope Chemical Communications 2020 56:6551-6554 DOI:10.1039/d0cc02107e PMID:32396160 PMCID:PMC7398699
- Lee, J. C., Kim, H. Y., Lee, S. J., Shin, J., Kim, H. V., Kim, K., Baek, S., Lee, D. H., Jeon, H., Kim, D., Yang, S. H., Han, G. H., et al. Discovery of Chemicals to Either Clear or Indicate Amyloid Aggregates by Targeting Memory‐Impairing Anti‐Parallel Aβ Dimers Angewandte Chemie-International Edition 2020 DOI:10.1002/anie.202002574
- Townsend, E. A., Bremer, P. T., Faunce, K. E., Negus, S. S., Aster, A. M., Robinson, H. L., Janda, K. D., Banks, M. L. Evaluation of a Dual Fentanyl/Heroin Vaccine on the Antinociceptive and Reinforcing Effects of a Fentanyl/Heroin Mixture in Male and Female Rats ACS Chemical Neuroscience 2020 11:1300-1310 DOI:10.1021/acschemneuro.0c00064 PMID:32271538
- Lin, L., Olson, M. E., Sugane, T., Turner, L. D., Tararina, M. A., Nielsen, A. L., Kurbanov, E. K., Pellett, S., Johnson, E. A., Cohen, S. M., Allen, K. N., Janda, K. D. Catch and Anchor Approach To Combat Both Toxicity and Longevity of Botulinum Toxin A Journal of Medicinal Chemistry 2020 63:11100-11120 DOI:10.1021/acs.jmedchem.0c01006 PMID:32886509 PMCID:PMC7581224
- Lee, J. C., Kim, H. Y., Lee, S. J., Shin, J., Kim, H. V., Kim, K., Baek, S., Lee, D. H., Jeon, H., Kim, D., Yang, S. H., Han, G. H., et al. Discovery of Chemicals to Either Clear or Indicate Amyloid Aggregates by Targeting Memory-Impairing Anti-Parallel Aβ Dimers Angewandte Chemie-International Edition 2020 59:11491-11500 DOI:10.1002/ange.202002574 PMID:32233096
- Tenney, R. D., Blake, S., Bremer, P. T., Zhou, B., Hwang, C. S., Poklis, J. L., Janda, K. D., Banks, M. L. Vaccine blunts fentanyl potency in male rhesus monkeys Neuropharmacology 2019 158 DOI:10.1016/j.neuropharm.2019.107730 PMID:31369740 PMCID:PMC6745253
- Olson, M. E., Sugane, T., Zhou, B., Janda, K. D. Consequence of hapten stereochemistry: an efficacious methamphetamine vaccine Journal of the American Chemical Society 2019 141:14089-14092 DOI:10.1021/jacs.9b07294 PMID:31479256
- Townsend, E. A., Blake, S., Faunce, K. E., Hwang, C. S., Natori, Y., Zhou, B., Bremer, P. T., Janda, K. D., Banks, M. L. Conjugate vaccine produces long-lasting attenuation of fentanyl vs. food choice and blocks expression of opioid withdrawal-induced increases in fentanyl choice in rats Neuropsychopharmacology 2019 44:1681-1689 DOI:10.1038/s41386-019-0385-9 PMID:31043682
- Lin, L., Olson, M. E., Eubanks, L. M., Janda, K. D. Strategies to counteract botulinum neurotoxin A: nature's deadliest biomolecule Accounts of Chemical Research 2019 52:2322-2331 DOI:10.1021/acs.accounts.9b00261 PMID:31322847
- Hwang, C. S., Smith, L. C., Wenthur, C. J., Ellis, B., Zhou, B., Janda, K. D. Heroin vaccine: Using titer, affinity, and antinociception as metrics when examining sex and strain differences Vaccine 2019 37:4155-4163 DOI:10.1016/j.vaccine.2019.05.061 PMID:31176539 PMCID:PMC6658211
- Smith, L. C., Bremer, P. T., Hwang, C. S., Zhou, B., Ellis, B., Hixon, M. S., Janda, K. D. Monoclonal antibodies for combating synthetic opioid intoxication Journal of the American Chemical Society 2019 141:10489-10503 DOI:10.1021/jacs.9b04872 PMID:31187995
- Nguyen, J. D., Grant, Y., Creehan, K. M., Hwang, C. S., Vandewater, S. A., Janda, K. D., Cole, M., Taffe, M. A. Δ9-tetrahydrocannabinol attenuates oxycodone self-administration under extended access conditions Neuropharmacology 2019 151:127-135 DOI:10.1016/j.neuropharm.2019.04.010 PMID:30980837 PMCID:PMC6510273
- Natoriti, Y., Hwang, C. S., Lin, L., Smith, L. C., Zhou, B., Janda, K. D. A chemically contiguous hapten approach for a heroin-fentanyl vaccine Beilstein Journal of Organic Chemistry 2019 15:1020-1031 DOI:10.3762/bjoc.15.100
- Wang, J., Merino, D. M., Light, N., Murphy, B. L., Wang, Y. D., Guo, X., Hodges, A. P., Chau, L. Q., Liu, K. W., Dhall, G., Asgharzadeh, S., Kiehna, E. N., et al. Mycand loss of p53 cooperate to drive formation of choroid plexus carcinoma Cancer Research 2019 79:2208-2219 DOI:10.1158/0008-5472.can-18-2565 PMID:30885981 PMCID:PMC6497574
- Wenthur, C. J., Gautam, R., Zhou, B., Vendruscolo, L. F., Leggio, L., Janda, K. D. Ghrelin receptor influence on cocaine reward is not directly dependent on peripheral acyl-ghrelin Scientific Reports 2019 9 DOI:10.1038/s41598-019-38549-z PMID:30755699 PMCID:PMC6372697
- Olson, M. E., Eubanks, L. M., Janda, K. D. Chemical interventions for the opioid crisis: key advances and remaining challenges Journal of the American Chemical Society 2019 141:1798-1806 DOI:10.1021/jacs.8b09756 PMID:30532973
- Hwang, C. S., Ellis, B., Zhou, B., Janda, K. D. Heat shock proteins: A dual carrier-adjuvant for an anti-drug vaccine against heroin Bioorganic & Medicinal Chemistry 2019 27:125-132 DOI:10.1016/j.bmc.2018.11.027 PMID:30497790
- Smith, L. C., Lin, L., Hwang, C. S., Zhou, B., Kubitz, D. M., Wang, H., Janda, K. D. Lateral flow assessment and unanticipated toxicity of Kratom Chemical Research in Toxicology 2019 32:113-121 DOI:10.1021/acs.chemrestox.8b00218 PMID:30380840
- Banks, M. L., Olson, M. E., Janda, K. D. Immunopharmacotherapies for treating opioid use disorder Trends in Pharmacological Sciences 2018 39:908-911 DOI:10.1016/j.tips.2018.08.001 PMID:30343725
- Kallupi, M., Xue, S., Zhou, B., Janda, K. D., George, O. An enzymatic approach reverses nicotine dependence, decreases compulsive-like intake, and prevents relapse Science Advances 2018 4 DOI:10.1126/sciadv.aat4751 PMID:30345354 PMCID:PMC6192681
- Shirey, R. J., Globisch, D., Eubanks, L. M., Hixon, M. S., Janda, K. D. Noninvasive urine biomarker lateral flow immunoassay for monitoring active onchocerciasis ACS Infectious Diseases 2018 4:1423-1431 DOI:10.1021/acsinfecdis.8b00163 PMID:30141624 PMCID:PMC6189908
- Hwang, C. S., Smith, L. C., Natori, Y., Ellis, B., Zhou, B., Janda, K. D. Improved admixture vaccine of fentanyl and heroin hapten immunoconjugates: antinociceptive evaluation of fentanyl-contaminated heroin ACS Omega 2018 3:11537-11543 DOI:10.1021/acsomega.8b01478 PMID:30288464 PMCID:PMC6166218
- Disney, M. D., Janda, K. D. Introduction Bioorganic & Medicinal Chemistry Letters 2018 28:2661-2662 DOI:10.1016/j.bmcl.2018.07.013 PMID:30029841
- Kimishima, A., Olson, M. E., Janda, K. D. Investigations into the efficacy of multi-component cocaine vaccines Bioorganic & Medicinal Chemistry Letters 2018 28:2779-2783 DOI:10.1016/j.bmcl.2017.12.043 PMID:29317163 PMCID:PMC6013332
- Jacob, N. T., Miranda, P. O., Shirey, R. J., Gautam, R., Zhou, B., Izquierdo, M. E. D., Hixon, M. S., Hart, J. R., Ueno, L., Vogt, P. K., Janda, K. D. Synthetic molecules for disruption of the MYC protein-protein interface Bioorganic & Medicinal Chemistry 2018 26:4234-4239 DOI:10.1016/j.bmc.2018.07.019 PMID:30037753
- Nguyen, J. D., Hwang, C. S., Grant, Y., Janda, K. D., Taffe, M. A. Prophylactic vaccination protects against the development of oxycodone self-administration Neuropharmacology 2018 138:292-303 DOI:10.1016/j.neuropharm.2018.06.026 PMID:29936242
- Tararina, M. A., Xue, S., Smith, L. C., Muellers, S. N., Miranda, P. O., Janda, K. D., Allen, K. N. Crystallography coupled with kinetic analysis provides mechanistic underpinnings of a nicotine-degrading enzyme Biochemistry 2018 57:3741-3751 DOI:10.1021/acs.biochem.8b00384 PMID:29812904
- Hwang, C. S., Smith, L. C., Natori, Y., Ellis, B., Zhou, B., Janda, K. D. Efficacious vaccine against heroin contaminated with fentanyl ACS Chemical Neuroscience 2018 9:1269-1275 DOI:10.1021/acschemneuro.8b00079 PMID:29558798 PMCID:PMC6013375
- Kimishima, A., Olson, M. E., Natori, Y., Janda, K. D. Efficient syntheses of cocaine vaccines and their in vivo evaluation ACS Medicinal Chemistry Letters 2018 9:411-416 DOI:10.1021/acsmedchemlett.8b00051 PMID:29795751 PMCID:PMC5949726
- Miranda, P. O., Cubitt, B., Jacob, N. T., Janda, K. D., de la Torre, J. C. Mining a Kröhnke pyridine library for anti-arenavirus activity ACS Infectious Diseases 2018 4:815-824 DOI:10.1021/acsinfecdis.7b00236 PMID:29405696
- Hwang, C. S., Bremer, P. T., Wenthur, C. J., Ho, S. O., Chiang, S., Ellis, B., Zhou, B., Fuji, G., Janda, K. D. Enhancing efficacy and stability of an antiheroin vaccine: examination of antinociception, opioid binding profile, and lethality Molecular Pharmaceutics 2018 15:1062-1072 DOI:10.1021/acs.molpharmaceut.7b00933 PMID:29420901
- Xue, S., Kallupi, M., Zhou, B., Smith, L. C., Miranda, P. O., George, O., Janda, K. D. An enzymatic advance in nicotine cessation therapy Chemical Communications 2018 54:1686-1689 DOI:10.1039/c7cc09134f PMID:29308799
- Olson, M. E., Janda, K. D. Vaccines to combat the opioid crisis Vaccines that prevent opioids and other substances of abuse from entering the brain could effectively treat addiction and abuse EMBO Reports 2018 19:5-9 DOI:10.15252/embr.201745322 PMID:29237715 PMCID:PMC5757212
- Xue, S., Seki, H., Remes, M., Silhar, P., Janda, K. Examination of α-exosite inhibitors against Botulinum neurotoxin A protease through structure-activity relationship studies of chicoric acid Bioorganic & Medicinal Chemistry Letters 2017 27:4956-4959 DOI:10.1016/j.bmcl.2017.10.021 PMID:29050781 PMCID:PMC5667901
- Hwang, C. S., Janda, K. D. A vision for vaccines: combating the opioid epidemic Biochemistry 2017 56:5625-5627 DOI:10.1021/acs.biochem.7b00948 PMID:28994583
- Wenthur, C. J., Zhou, B., Janda, K. D. Vaccine-driven pharmacodynamic dissection and mitigation of fenethylline psychoactivity Nature 2017 548:476-+ DOI:10.1038/nature23464 PMID:28813419
- Wenthur, C. J., Cai, X., Ellis, B. A., Janda, K. D. Augmenting the efficacy of anti-cocaine catalytic antibodies through chimeric hapten design and combinatorial vaccination Bioorganic & Medicinal Chemistry Letters 2017 27:3666-3668 DOI:10.1016/j.bmcl.2017.07.014 PMID:28709828 PMCID:PMC5584565
- Globisch, D., Eubanks, L. M., Shirey, R. J., Pfarr, K. M., Wanji, S., Debrah, A. Y., Hoerauf, A., Janda, K. D. Validation of onchocerciasis biomarker N-acetyltyramine-O-glucuronide (NATOG) Bioorganic & Medicinal Chemistry Letters 2017 27:3436-3440 DOI:10.1016/j.bmcl.2017.05.082 PMID:28600214 PMCID:PMC5510726
- Jacob, N. T., Anraku, K., Kimishima, A., Zhou, B., Collins, K. C., Lockner, J. W., Ellis, B. A., Janda, K. D. A bioconjugate leveraging xenoreactive antibodies to alleviate cocaine-induced behavior Chemical Communications 2017 53:8156-8159 DOI:10.1039/c7cc04055e PMID:28677711
- Bremer, P. T., Janda, K. D. Conjugate vaccine immunotherapy for substance use disorder Pharmacological Reviews 2017 69:298-315 DOI:10.1124/pr.117.013904 PMID:28634286
- Bremer, P. T., Schlosburg, J. E., Banks, M. L., Steele, F. F., Zhou, B., Poklis, J. L., Janda, K. D. Development of a clinically viable heroin vaccine Journal of the American Chemical Society 2017 139:8601-8611 DOI:10.1021/jacs.7b03334 PMID:28574716
- Nguyen, J. D., Bremer, P. T., Hwang, C. S., Vandewater, S. A., Collins, K. C., Creehan, K. M., Janda, K. D., Taffe, M. A. Effective active vaccination against methamphetamine in female rats Drug and Alcohol Dependence 2017 175:179-186 DOI:10.1016/j.drugalcdep.2017.03.005 PMID:28437722
- Bremer, P. T., Pellett, S., Carolan, J. P., Tepp, W. H., Eubanks, L. M., Allen, K. N., Johnson, E. A., Janda, K. D. Metal ions effectively ablate the action of Botulinum neurotoxin A Journal of the American Chemical Society 2017 139:7264-7272 DOI:10.1021/jacs.7b01084 PMID:28475321
- Anraku, K., Sato, S., Jacob, N. T., Eubanks, L. M., Ellis, B. A., Janda, K. D. The design and synthesis of an α-Gal trisaccharide epitope that provides a highly specific anti-Gal immune response Organic & Biomolecular Chemistry 2017 15:2979-2992 DOI:10.1039/c7ob00448f PMID:28294277
- Srinivasulu, V., Janda, K. D., Abu-Yousef, I. A., O'Connor, M. J., Al-Tel, T. H. A modular CuI-L-proline catalyzed one-pot route for the rapid access of constrained and privileged hetero-atom-linked medium-sized ring systems Tetrahedron 2017 73:2139-2150 DOI:10.1016/j.tet.2017.02.061
- Gooyit, M., Miranda, P. O., Wenthur, C. J., Ducime, A., Janda, K. D. Influencing antibody-mediated attenuation of methamphetamine CNS distribution through vaccine linker design ACS Chemical Neuroscience 2017 8:468-472 DOI:10.1021/acschemneuro.6b00389 PMID:27958709
- Galinato, M. H., Lockner, J. W., Fannon-Pavlich, M. J., Sobieraj, J. C., Staples, M. C., Somkuwar, S. S., Ghofranian, A., Chaing, S., Navarro, A. I., Joea, A., Luikart, B. W., Janda, K. D., et al. A synthetic small-molecule Isoxazole-9 protects against methamphetamine relapse Molecular Psychiatry 2017 23:629-638 DOI:10.1038/mp.2017.46 PMID:28348387 PMCID:PMC5617764
- Adler, M., Phung, C. H., Singh, A. K., Janda, K. D. Newly designed quinolinol inhibitors mitigate the effects of botulinum neurotoxin A in enzymatic, cell-based, and ex vivo assays Journal of Medicinal Chemistry 2017 60:338-348 DOI:10.1021/acs.jmedchem.6b01393 PMID:27966961
- Kimishima, A., Wenthur, C. J., Zhou, B., Janda, K. D. An Advance in Prescription Opioid Vaccines: Overdose Mortality Reduction and Extraordinary Alteration of Drug Half-Life ACS Chemical Biology 2017 12:36-40 DOI:10.1021/acschembio.6b00977 PMID:28103678
- Tararina, M. A., Janda, K. D., Allen, K. N. Structural analysis provides mechanistic insight into nicotine oxidoreductase from pseudomonas putida Biochemistry 2016 55:6595-6598 DOI:10.1021/acs.biochem.6b00963 PMID:27933790
- Kimishima, A., Wenthur, C. J., Eubanks, L. M., Sato, S., Janda, K. D. Cocaine vaccine development: evaluation of carrier and adjuvant combinations that activate multiple toll-like receptors Molecular Pharmaceutics 2016 13:3884-3890 DOI:10.1021/acs.molpharmaceut.6b00682 PMID:27717287
- Evans, S. M., Foltin, R. W., Hicks, M. J., Rosenberg, J. B., De, B. P., Janda, K. D., Kaminsky, S. M., Crystal, R. G. Efficacy of an adenovirus-based anti-cocaine vaccine to reduce cocaine self-administration and reacqusition using a choice procedure in rhesus macaques Pharmacology, Biochemistry and Behavior 2016 150:76-86 DOI:10.1016/j.pbb.2016.09.008 PMID:27697554 PMCID:PMC5145743
- Zhou, B., Eubanks, L. M., Jacob, N. T., Ellis, B., Roberts, A. J., Janda, K. D. Studies towards the improvement of an anti-cocaine monoclonal antibody for treatment of acute overdose Bioorganic & Medicinal Chemistry Letters 2016 26:5078-5081 DOI:10.1016/j.bmcl.2016.08.081 PMID:27599743 PMCID:PMC5050165
- Nguyen, J. D., Bremer, P. T., Ducime, A., Creehan, K. M., Kisby, B. R., Taffe, M. A., Janda, K. D. Active vaccination attenuates the psychostimulant effects of α-PVP and MDPV in rats Neuropharmacology 2016 116:1-8 DOI:10.1016/j.neuropharm.2016.12.005 PMID:27956054 PMCID:PMC5385148
- Gooyit, M., Janda, K. D. Reprofiled anthelmintics abate hypervirulent stationary-phase Clostridium difficile Scientific Reports 2016 6 DOI:10.1038/srep33642 PMID:27633064 PMCID:PMC5025651
- Gooyit, M. D., Janda, K. D. Modulation of the surface-layer protein of clostridium difficile through Cwp84 inhibition ACS Infectious Diseases 2016 2:465-470 DOI:10.1021/acsinfecdis.6b00061 PMID:27626098
- Collins, K. C., Tsuchikama, K., Lowery, C. A., Zhu, J., Janda, K. D. Dissecting AI-2-mediated quorum sensing through C5-analogue synthesis and biochemical analysis Tetrahedron 2016 72:3593-3598 DOI:10.1016/j.tet.2015.08.063 PMID:27340303 PMCID:PMC4915392
- Seki, H., Xue, S., Pellet, S., Silhar, P., Johnson, E. A., Janda, K. D. Cellular protection of SNAP-25 against botulinum neurotoxin/A: inhibition of thioredoxin reductase through a suicide substrate mechanism Journal of the American Chemical Society 2016 138:5568-5575 DOI:10.1021/jacs.5b12929 PMID:27070533 PMCID:PMC4881748
- Collins, K. C., Schlosburg, J. E., Bremer, P. T., Janda, K. D. Methamphetamine vaccines: improvement through hapten design Journal of Medicinal Chemistry 2016 59:3878-3885 DOI:10.1021/acs.jmedchem.6b00084 PMID:27054372
- Taffe, M. A., Nguyen, J. D., Bremer, P. T., Vandewater, S. A., Creehan, K. M., Janda, K. D. Active anti-methamphetamine vaccination attenuates the effects of methamphetamine The FASEB Journal 2016 30
- Jacob, N. T., Lockner, J. W., Schlosburg, J. E., Ellis, B. A., Eubanks, L. M., Janda, K. D. Investigations of enantiopure nicotine haptens using an adjuvanting carrier in anti-nicotine vaccine development Journal of Medicinal Chemistry 2016 59:2523-2529 DOI:10.1021/acs.jmedchem.5b01676 PMID:26918428
- Tsuchikama, K., Gooyit, M., Harris, T. L., Zhu, J., Globisch, D., Kaufmann, G. F., Janda, K. D. Glycation reactivity of a quorum-sensing signaling molecule Angewandte Chemie-International Edition 2016 55:4002-4006 DOI:10.1002/anie.201511911 PMID:26890076 PMCID:PMC4965832
- Bremer, P. T., Kimishima, A., Schlosburg, J. E., Zhou, B., Collins, K. C., Janda, K. D. Combatting synthetic designer opioids: a conjugate vaccine ablates lethal doses of fentanyl class drugs Angewandte Chemie-International Edition 2016 55:3772-3775 DOI:10.1002/anie.201511654 PMID:26879590 PMCID:PMC4860013
- Hart, J. R., Weinberg, M. S., Morris, K. V., Roberts, T. C., Janda, K. D., Garner, A. L., Vogt, P. K. MINCR is not a MYC-induced lncRNA Proceedings of the National Academy of Sciences of the United States of America 2016 113:E496-E497 DOI:10.1073/pnas.1519903113 PMID:26811502 PMCID:PMC4747730
- Harris, T. L., Wenthur, C. J., Diego-Taboada, A., Mackenzie, G., Corbitt, T. S., Janda, K. D. Lycopodium clavatum exine microcapsules enable safe oral delivery of 3,4-diaminopyridine for treatment of botulinum neurotoxin A intoxication Chemical Communications 2016 52:4187-4190 DOI:10.1039/c6cc00615a PMID:26906286
- Bremer, P. T., Xue, S., Janda, K. D. Picolinic acids as β-exosite inhibitors of botulinum neurotoxin A light chain Chemical Communications 2016 52:12521-12524 DOI:10.1039/c6cc06749b PMID:27722252 PMCID:PMC5085802
- Globisch, D., Specht, S., Pfarr, K. M., Eubanks, L. M., Hoerauf, A., Janda, K. D. Litomosoides sigmodontis: A jird urine metabolome study Bioorganic & Medicinal Chemistry Letters 2015 25:5804-5807 DOI:10.1016/j.bmcl.2015.10.037 PMID:26573416
- Miller, M. L., Aarde, S. M., Moreno, A. Y., Creehan, K. M., Janda, K. D., Taffe, M. A. Effects of active anti-methamphetamine vaccination on intravenous self-administration in rats Drug and Alcohol Dependence 2015 153:29-36 DOI:10.1016/j.drugalcdep.2015.06.014 PMID:26118833 PMCID:PMC4509945
- Gooyit, M., Harris, T. L., Tricoche, N., Javor, S., Lustigman, S., Janda, K. D. Onchocerca volvulus molting inhibitors identified through scaffold hopping ACS Infectious Diseases 2015 1:198-202 DOI:10.1021/acsinfecdis.5b00017 PMID:27622649
- Zhu, J., Cai, X., Harris, T. L., Gooyit, M., Wood, M., Lardy, M., Janda, K. D. Disarming Pseudomonas aeruginosa virulence factor LasB by leveraging a Caenorhabditis elegans infection model Chemistry & Biology 2015 22:483-491 DOI:10.1016/j.chembiol.2015.03.012 PMID:25892201
- Gooyit, M., Tricoche, N., Javor, S., Lustigman, S., Janda, K. D. Exploiting the polypharmacology of ß-carbolines to disrupt O. volvulus molting ACS Medicinal Chemistry Letters 2015 6:339-343 DOI:10.1021/ml500516r PMID:25815157 PMCID:PMC4360149
- Lockner, J. W., Eubanks, L. M., Choi, J. L., Lively, J. M., Schlosburg, J. E., Collins, K. C., Globisch, D., Rosenfeld-Gunn, R. J., Wilson, I. A., Janda, K. D. Flagellin as carrier and adjuvant in cocaine vaccine development Molecular Pharmaceutics 2015 12:653-662 DOI:10.1021/mp500520r PMID:25531528 PMCID:PMC4319694
- Lockner, J. W., Lively, J. M., Collins, K. C., Vendruscolo, J. C. M., Azar, M. R., Janda, K. D. A conjugate vaccine using enantiopure hapten imparts superior nicotine-binding capacity Journal of Medicinal Chemistry 2015 58:1005-1011 DOI:10.1021/jm501625j PMID:25493909
- Cai, X., Janda, K. D. A chemoenzymatic approach toward the preparation of site-specific antibody-drug conjugates Tetrahedron Letters 2015 56:3172-3175 DOI:10.1016/j.tetlet.2014.12.025
- Sue, S., Schlosburg, J. E., Janda, K. D. A new strategy for smoking cessation: characterization of a bacterial enzyme for the degradation of nicotine Journal of the American Chemical Society 2015 137:10136-10139 DOI:10.1021/jacs.5b06605 PMID:26237398
- Pippione, A. C., Dosio, F., Ducime, A., Federico, A., Martina, K., Sainas, S., Frolund, B., Gooyit, M., Janda, K. D., Boschi, D., Lolli, M. L. Substituted 4-hydroxy-1,2,3-triazoles: synthesis, characterization and first drug design applications through bioisosteric modulation and scaffold hopping approaches MedChemComm 2015 6:1285-1292 DOI:10.1039/c5md00182j
- Seki, H., Xue, S., Hixon, M. S., Pellett, S., Remes, M., Johnson, E. A., Janda, K. D. Toward the discovery of dual inhibitors for botulinum neurotoxin A: concomitant targeting of endocytosis and light chain protease activity Chemical Communications 2015 51:6226-6229 DOI:10.1039/c5cc00677e PMID:25759983
- Xue, S., Javor, S., Hixon, M. S., Janda, K. D. Probing BoNT/A protease exosites: implications for inhibitor design and light chain longevity Biochemistry 2014 53:6820-6824 DOI:10.1021/bi500950x PMID:25295706 PMCID:PMC4222541
- Raffeiner, P., Rock, R., Schraffl, A., Hartl, M., Hart, J. R., Janda, K. D., Vogt, P. K., Stefan, E., Bister, K. In vivo quantification and perturbation of Myc-Max interactions and the impact on oncogenic potential Oncotarget 2014 5:8869-8878 DOI:10.18632/oncotarget.2588 PMID:25326649 PMCID:PMC4253403
- Eubanks, L. M., Ellis, B. A., Cai, X., Schlosburg, J. E., Janda, K. D. A human recombinant monoclonal antibody to cocaine: preparation, characterization and behavioral studies Bioorganic & Medicinal Chemistry Letters 2014 24:4664-4666 DOI:10.1016/j.bmcl.2014.08.035 PMID:25205191 PMCID:PMC4185020
- Hart, J. R., Garner, A. L., Yu, J., Ito, Y., Sun, M. H., Ueno, L., Rhee, J. K., Baksh, M. M., Stefan, E., Hartl, M., Bister, K., Vogt, P. K., et al. Inhibitor of MYC identified in a Krohnke pyridine library Proceedings of the National Academy of Sciences of the United States of America 2014 111:12556-12561 DOI:10.1073/pnas.1319488111 PMID:25114221 PMCID:PMC4151726
- Harris, T. L., Lowery, C. A., Hixon, M. S., Janda, K. D. A platform stratifying a sequestering agent and a pharmacological antagonist as a means to negate botulinum neurotoxicity ACS Chemical Neuroscience 2014 5:632-636 DOI:10.1021/cn500135h PMID:25000171 PMCID:PMC4140587
- Bremer, P. T., Hixon, M. S., Janda, K. D. Benzoquinones as inhibitors of botulinum neurotoxin serotype A Bioorganic & Medicinal Chemistry 2014 22:3971-3981 DOI:10.1016/j.bmc.2014.06.004 PMID:24984937 PMCID:PMC4138410
- Gooyit, M., Tricoche, N., Lustigman, S., Janda, K. D. Dual protonophore-chitinase inhibitors dramatically affect O. volvulus molting Journal of Medicinal Chemistry 2014 57:5792-5799 DOI:10.1021/jm5006435 PMID:24918716 PMCID:PMC4216208
- Jacob, N. T., Lockner, J. W., Kravchenko, V. V., Janda, K. D. Pharmacophore reassignment for induction of the immunosurveillance cytokine TRAIL Angewandte Chemie-International Edition 2014 53:6628-6631 DOI:10.1002/anie.201402133 PMID:24838721
- Hicks, M. J., Kaminsky, S. M., De, B. P., Rosenberg, J. B., Evans, S. M., Foltin, R. W., Andrenyak, D. M., Moody, D. E., Koob, G. F., Janda, K. D., Arbona, R. J. R., Lepherd, M. L., et al. Fate of systemically administered cocaine in nonhuman primates treated with the dAd5GNE anticocaine vaccine Human Gene Therapy Clinical Development 2014 25:40-49 DOI:10.1089/humc.2013.231 PMID:24649839 PMCID:PMC4047994
- Bremer, P. T., Schlosburg, J. E., Lively, J. M., Janda, K. D. Injection route and TLR9 agonist addition significantly impact heroin vaccine efficacy Molecular Pharmaceutics 2014 11:1075-1080 DOI:10.1021/mp400631w PMID:24517171 PMCID:PMC3993894
- Collins, K. C., Janda, K. D. Investigating hapten clustering as a strategy to enhance vaccines against drugs of abuse Bioconjugate Chemistry 2014 25:593-600 DOI:10.1021/bc500016k PMID:24521489 PMCID:PMC3983143
- Seki, H., Pellett, S., Silhar, P., Stowe, G. N., Blanco, B., Lardy, M. A., Johnson, E. A., Janda, K. D. Synthesis/biological evaluation of hydroxamic acids and their prodrugs as inhibitors for Botulinum neurotoxin A light chain Bioorganic & Medicinal Chemistry 2014 22:1208-1217 DOI:10.1016/j.bmc.2013.11.053 PMID:24360826 PMCID:PMC3919520
- Collins, K. C., Schlosburg, J. E., Lockner, J. W., Bremer, P. T., Ellis, B. A., Janda, K. D. Lipid tucaresol as an adjuvant for methamphetamine vaccine development Chemical Communications 2014 50:4079-4081 DOI:10.1039/c4cc00682h PMID:24615284 PMCID:PMC4033696
- Lowery, C. A., Adler, M., Borrell, A., Janda, K. D. Scorpion toxins for the reversal of BoNT-induced paralysis Bioorganic & Medicinal Chemistry Letters 2013 23:6743-6746 DOI:10.1016/j.bmcl.2013.10.029 PMID:24252544 PMCID:PMC3869784
- Cai, X., Whitfield, T., Moreno, A. Y., Grant, Y., Hixon, M. S., Koob, G. F., Janda, K. D. Probing the effects of hapten stability on cocaine vaccine immunogenicity Molecular Pharmaceutics 2013 10:4176-4184 DOI:10.1021/mp400214w PMID:23927436 PMCID:PMC3946501
- Silhar, P., Eubanks, L. M., Seki, H., Pellet, S., Javor, S., Tepp, W. H., Johnson, E. A., Janda, K. D. Targeting botulinum A cellular toxicity: a prodrug approach Journal of Medicinal Chemistry 2013 56:7870-7879 DOI:10.1021/jm400873n PMID:24127873 PMCID:PMC3880648
- Maoz, A., Hicks, M. J., Vallabhjosula, S., Synan, M., Kothari, P. J., Dyke, J. P., Ballon, D. J., Kaminsky, S. M., De, B. P., Rosenberg, J. B., Martinez, D., Koob, G. F., et al. Adenovirus capsid-based anti-cocaine vaccine prevents cocaine from binding to the nonhuman primate CNS dopamine transporter Neuropsychopharmacology 2013 38:2170-2178 DOI:10.1038/npp.2013.114 PMID:23660705 PMCID:PMC3773666
- Lowery, C. A., Matamouros, S., Niessen, S., Zhu, J., Scolnick, J., Lively, J. M., Cravatt, B. F., Miller, S. I., Kaufmann, G. F., Janda, K. D. A chemical biology approach to interrogate quorum-sensing regulated behaviors at the molecular and cellular level Chemistry & Biology 2013 20:903-911 DOI:10.1016/j.chembiol.2013.05.009 PMID:23890008 PMCID:PMC3736722
- Garner, A. L., Fullagar, J. L., Day, J. A., Cohen, S. M., Janda, K. D. Development of a high-throughput screen and its use in the discovery of Streptococcus pneumoniae immunoglobulin A1 protease inhibitors Journal of the American Chemical Society 2013 135:10014-10017 DOI:10.1021/ja404180x PMID:23808771 PMCID:PMC3810181
- Matyas, G. R., Mayorov, A. V., Rice, K. C., Jacobson, A. E., Cheng, K. J., Iyer, M. R., Li, F. Y., Janda, K. D., Alving, C. R., Beck, Z. Liposomes containing monophosphoryl lipid A: A potent adjuvant system for inducing antibodies to heroin hapten analogs Vaccine 2013 31:2804-2810 DOI:10.1016/j.vaccine.2013.04.027 PMID:23624097 PMCID:PMC4120113
- Kravchenko, V., Garner, A. L., Mathison, J., Seit-Nebi, A., Yu, J., Gileva, I. P., Ulevitch, R., Janda, K. D. Facilitating cytokine-mediated cancer cell death by proteobacterial N-acylhomoserine lactones ACS Chemical Biology 2013 1117-1120 DOI:10.1021/cb4000184 PMID:23517377 PMCID:PMC3755046
- Rosenberg, J. B., De, B. P., Hicks, M. J., Janda, K. D., Kaminsky, S. M., Worgall, S., Crystal, R. G. Suppression of nicotine-induced pathophysiology by an adenovirus hexon-based antinicotine vaccine Human Gene Therapy 2013 24:595-603 DOI:10.1089/hum.2012.245 PMID:23611296 PMCID:PMC3689186
- Zhu, J., Hixon, M. S., Globisch, D., Kaufmann, G. F., Janda, K. D. Mechanistic insights into the LsrK kinase required for autoinducer-2 quorum sensing activation Journal of the American Chemical Society 2013 135:7827-7830 DOI:10.1021/ja4024989 PMID:23672516 PMCID:PMC3736694
- Schlosburg, J. E., Vendruscolo, L. F., Bremer, P. T., Lockner, J. W., Wade, C. L., Nunes, A. A., Stowe, G. N., Edwards, S., Janda, K. D., Koob, G. F. Dynamic vaccine blocks relapse to compulsive intake of heroin Proceedings of the National Academy of Sciences of the United States of America 2013 110:9036-9041 DOI:10.1073/pnas.1219159110 PMID:23650354 PMCID:PMC3670323
- Cai, X., Whitfield, T., Hixon, M. S., Grant, Y., Koob, G. F., Janda, K. D. Probing active cocaine vaccination performance through catalytic and noncatalytic hapten design Journal of Medicinal Chemistry 2013 56:3701-3709 DOI:10.1021/jm400228w PMID:23627877 PMCID:PMC3691275
- Miller, M. L., Moreno, A. Y., Aarde, S. M., Creehan, K. M., Vandewater, S. A., Vaillancourt, B. D., Wright, M. J., Jr., Janda, K. D., Taffe, M. A. A methamphetamine vaccine attenuates methamphetamine-induced disruptions in thermoregulation and activity in rats Biological Psychiatry 2013 73:721-8 DOI:10.1016/j.biopsych.2012.09.010 PMID:23098894 PMCID:PMC3561477
- Struss, A. K., Nunes, A., Waalen, J., Lowery, C. A., Pullanikat, P., Denery, J. R., Conrad, D. J., Kaufmann, G. F., Janda, K. D. Toward implementation of quorum sensing autoinducers as biomarkers for infectious disease states Analytical Chemistry 2013 85:3355-62 DOI:10.1021/ac400032a PMID:23391272 PMCID:PMC3604138
- Globisch, D., Moreno, A. Y., Hixon, M. S., Nunes, A. A., Denery, J. R., Specht, S., Hoerauf, A., Janda, K. D. Onchocerca volvulus-neurotransmitter tyramine is a biomarker for river blindness Proceedings of the National Academy of Sciences of the United States of America 2013 110:4218-4223 DOI:10.1073/pnas.1221969110 PMID:23440222 PMCID:PMC3600455
- Silhar, P., Silvaggi, N. R., Pellett, S., Capkova, K., Johnson, E. A., Allen, K. N., Janda, K. D. Evaluation of adamantane hydroxamates as botulinum neurotoxin inhibitors: Synthesis, crystallography, modeling, kinetic and cellular based studies Bioorganic & Medicinal Chemistry 2013 21:1344-1348 DOI:10.1016/j.bmc.2012.12.001 PMID:23340139 PMCID:PMC3574188
- Cai, X. Q., Tsuchikama, K., Janda, K. D. Modulating cocaine vaccine potency through hapten fluorination Journal of the American Chemical Society 2013 135:2971-2974 DOI:10.1021/ja400356g PMID:23398531 PMCID:PMC3637684
- Lockner, J. W., Ho, S. O., McCague, K. C., Chiang, S. M., Do, T. Q., Fujii, G., Janda, K. D. Enhancing nicotine vaccine immunogenicity with liposomes Bioorganic & Medicinal Chemistry Letters 2013 23:975-978 DOI:10.1016/j.bmcl.2012.12.048 PMID:23313243 PMCID:PMC3557556
- Silhar, P., Lardy, M. A., Hixon, M. S., Shoemaker, C. B., Barbieri, J. T., Struss, A. K., Lively, J. M., Javor, S., Janda, K. D. The C-terminus of botulinum A protease has profound and unanticipated kinetic consequences upon the catalytic cleft ACS Medicinal Chemistry Letters 2013 4:283-287 DOI:10.1021/ml300428s PMID:23565325 PMCID:PMC3615567
- Fullagar, J. L., Garner, A. L., Struss, A. K., Day, J. A., Martin, D. P., Yu, J., Cai, X., Janda, K. D., Cohen, S. M. Antagonism of a zinc metalloprotease using a unique metal-chelating scaffold: Tropolones as inhibitors of p. Aeruginosa elastase Chemical Communications 2013 49:3197-9 DOI:10.1039/c3cc41191e PMID:23482955 PMCID:PMC3618488
- De, B. P., Pagovich, O. E., Hicks, M. J., Rosenberg, J. B., Moreno, A. Y., Janda, K. D., Koob, G. F., Worgall, S., Kaminsky, S. M., Sondhi, D., Crystal, R. G. Disrupted adenovirus-based vaccines against small addictive molecules circumvent anti-adenovirus immunity Human Gene Therapy 2013 24:58-66 DOI:10.1089/hum.2012.163 PMID:23140508 PMCID:PMC3555097
- Garner, A. L., Yu, J., Struss, A. K., Kaufmann, G. F., Kravchenko, V. V., Janda, K. D. Immunomodulation and the quorum sensing molecule 3-oxo-C-12-homoserine lactone: The importance of chemical scaffolding for probe development Chemical Communications 2013 49:1515-1517 DOI:10.1039/c3cc38851d PMID:23328974 PMCID:PMC3566768
- Bremer, P. T., Janda, K. D. Investigating the effects of a hydrolytically stable hapten and a Th1 adjuvant on heroin vaccine performance Journal of Medicinal Chemistry 2012 55:10776-10780 DOI:10.1021/jm301262z PMID:23134263 PMCID:PMC3527012
- von Hoven, G., Kloft, N., Neukirch, C., Ebinger, S., Bobkiewicz, W., Weis, S., Boller, K., Janda, K. D., Husmann, M. Modulation of translation and induction of autophagy by bacterial exoproducts Medical Microbiology and Immunology 2012 201:409-418 DOI:10.1007/s00430-012-0271-0 PMID:22991039 PMCID:PMC3470817
- Moreno, A. Y., Azar, M. R., Koob, G. F., Janda, K. D. Probing the protective effects of a conformationally constrained nicotine vaccine Vaccine 2012 30:6665-6670 DOI:10.1016/j.vaccine.2012.08.064 PMID:22963803
- Tsuchikama, K., Zhu, J., Lowery, C. A., Kaufmann, G. F., Janda, K. D. C4-alkoxy-hpd: A potent class of synthetic modulators surpassing nature in al-2 quorum sensing Journal of the American Chemical Society 2012 134:13562-13564 DOI:10.1021/ja305532y PMID:22866957 PMCID:PMC3438919
- Garner, A. L., Struss, A. K., Fullagar, J. L., Agrawal, A., Moreno, A. Y., Cohen, S. M., Janda, K. D. 3-hydroxy-1-alkyl-2-methylpyridine-4(1H)-thiones: inhibition of the Pseudomonas aeruginosa virulence factor LasB ACS Medicinal Chemistry Letters 2012 3:668-672 DOI:10.1021/ml300128f PMID:23181168 PMCID:PMC3501683
- Garner, A. L., Kim, S. K., Zhu, J., Struss, A. K., Watkins, R., Feske, B. D., Kaufmann, G. F., Janda, K. D. Stereochemical insignificance discovered in Acinetobacter baumannii quorum sensing PLoS One 2012 7:e37102 DOI:10.1371/journal.pone.0037102 PMID:22629354 PMCID:PMC3358330
- Rosenberg, J. B., Hicks, M. J., De, B. P., Pagovich, O., Frenk, E., Janda, K. D., Wee, S., Koob, G. F., Hackett, N. R., Kaminsky, S. M., Worgall, S., Tignor, N., et al. AAVrh.10-mediated expression of an anti-cocaine antibody mediates persistent passive immunization that suppresses cocaine-induced behavior Human Gene Therapy 2012 23:451-459 DOI:10.1089/hum.2011.178 PMID:22486244 PMCID:PMC3360503
- Treweek, J. B., Janda, K. D. An antidote for acute cocaine toxicity Molecular Pharmaceutics 2012 9:969-978 DOI:10.1021/mp200588v PMID:22380623 PMCID:PMC3319285
- Wee, S., Hicks, M. J., De, B. P., Rosenberg, J. B., Moreno, A. Y., Kaminsky, S. M., Janda, K. D., Crystal, R. G., Koob, G. F. Novel cocaine vaccine linked to a disrupted adenovirus gene transfer vector blocks cocaine psychostimulant and reinforcing effects Neuropsychopharmacology 2012 37:1083-1091 DOI:10.1038/npp.2011.200 PMID:21918504 PMCID:PMC3306868
- Kravchenko, V. V., Gloeckner, C., Stowe, G. N., Kang, Y. J., Tobias, P. S., Mathison, J. C., Ulevitch, R. J., Kaufmann, G. F., Janda, K. D. The use of small molecule probes to study spatially separated stimulus-induced signaling pathways Bioorganic & Medicinal Chemistry Letters 2012 22:2043-2045 DOI:10.1016/j.bmcl.2012.01.024 PMID:22300658 PMCID:PMC3288742
- Zakhari, J. S., Zorrilla, E. P., Zhou, B., Mayorov, A. V., Janda, K. D. Oligoclonal antibody targeting ghrelin increases energy expenditure and reduces food intake in fasted mice Molecular Pharmaceutics 2012 9:281-289 DOI:10.1021/mp200376c PMID:22149064 PMCID:PMC3273630
- Romano, A. A., Hahn, T., Davis, N., Lowery, C. A., Struss, A. K., Janda, K. D., Bottger, L. H., Matzanke, B. F., Carrano, C. J. The Fe(III) and Ga(III) coordination chemistry of 3-(1-hydroxymethylidene) and 3-(1-hydroxydecylidene)-5-(2-hydroxyethyl)pyrrolidine-2,4-dione: Novel tetramic acid degradation products of homoserine lactone bacterial quorum sensing molecules Journal of Inorganic Biochemistry 2012 107:96-103 DOI:10.1016/j.jinorgbio.2011.10.009 PMID:22178671 PMCID:PMC3258344
- Globisch, D., Lowery, C. A., McCague, K. C., Janda, K. D. Uncharacterized 4,5-dihydroxy-2,3-pentanedione (DPD) molecules revealed through NMR spectroscopy: Implications for a greater signaling diversity in bacterial species Angewandte Chemie-International Edition 2012 51:4204-4208 DOI:10.1002/anie.201109149 PMID:22378693 PMCID:PMC3505754
- Janda, K. D., Treweek, J. B. Vaccines targeting drugs of abuse: Is the glass half-empty or half-full? Nature Reviews Immunology 2012 12:67-72 DOI:10.1038/nri3130 PMID:22173478
- Koob, G., Hicks, M. J., Wee, S., Rosenberg, J. B., De, B. P., Kaminksy, S. M., Moreno, A., Janda, K. D., Crystal, R. G. Anti-cocaine vaccine based on coupling a cocaine analog to a disrupted adenovirus CNS and Neurological Disorders-Drug Targets 2011 10:899-904 PMID:22229312 PMCID:PMC3369545
- Hoon, S., Zhou, B., Janda, K. D., Brenner, S., Scolnick, J. Aptamer selection by high-throughput sequencing and informatic analysis Biotechniques 2011 51:413-416 DOI:10.2144/000113786 PMID:22150332
- Moreno, A. Y., Janda, K. D. Current challenges for the creation of effective vaccines against drugs of abuse Expert Review of Vaccines 2011 10:1637-1639 DOI:10.1586/erv.11.145 PMID:22085165
- Stowe, G. N., Schlosburg, J. E., Vendruscolo, L. F., Edwards, S., Misra, K. K., Schulteis, G., Zakhari, J. S., Koob, G. F., Janda, K. D. Developing a vaccine against multiple psychoactive targets: a case study of heroin CNS & Neurological Disorders-Drug Targets 2011 10:865-875 PMID:22229311 PMCID:PMC3327724
- Zakhari, J. S., Kinoyama, I., Hixon, M. S., Di Mola, A., Globisch, D., Janda, K. D. Formulating a new basis for the treatment against botulinum neurotoxin intoxication: 3,4-Diaminopyridine prodrug design and characterization Bioorganic & Medicinal Chemistry 2011 19:6203-6209 DOI:10.1016/j.bmc.2011.09.019 PMID:21975066 PMCID:PMC3196298
- Li, Z. R., Garner, A. L., Gloeckner, C., Janda, K. D., Carlow, C. K. Targeting the Wolbachia cell division protein FtsZ as a new approach for antifilarial therapy PLoS Neglected Tropical Diseases 2011 5:e1411 DOI:10.1371/journal.pntd.0001411 PMID:22140592 PMCID:PMC3226453
- Liu, Y., Jiang, P. F., Capkova, K., Xue, D., Ye, L. W., Sinha, S. C., Mackman, N., Janda, K. D., Liu, C. Tissue factor-activated coagulation cascade in the tumor microenvironment is critical for tumor progression and an effective target for therapy Cancer Research 2011 71:6492-6502 DOI:10.1158/0008-5472.can-11-1145 PMID:21880589
- Garner, A. L., Park, J., Zakhari, J. S., Lowery, C. A., Struss, A. K., Sawada, D., Kaufmann, G. F., Janda, K. D. A multivalent probe for AI-2 quorum-sensing receptors Journal of the American Chemical Society 2011 133:15934-15937 DOI:10.1021/ja207556d PMID:21913711 PMCID:PMC3203215
- Tsuchikama, K., Lowery, C. A., Janda, K. D. Probing autoinducer-2 based quorum sensing: The biological consequences of molecules unable to traverse equilibrium states Journal of Organic Chemistry 2011 76:6981-6989 DOI:10.1021/jo200882k PMID:21678949 PMCID:PMC3162994
- Stowe, G. N., Vendruscolo, L. F., Edwards, S., Schlosburg, J. E., Misra, K. K., Schulteis, G., Mayorov, A. V., Zakhari, J. S., Koob, G. F., Janda, K. D. A vaccine strategy that induces protective immunity against heroin Journal of Medicinal Chemistry 2011 54:5195-5204 DOI:10.1021/jm200461m PMID:21692508 PMCID:PMC3142939
- Garner, A. L., Goeckner, C., Tricoche, N., Zakhari, J. S., Samje, M., Cho-Ngwa, F., Lustigman, S., Janda, K. D. Design, synthesis, and biological activities of closantel analogues: structural promiscuity and its impact on Onchocerca volvulus Journal of Medicinal Chemistry 2011 54:3963-3972 DOI:10.1021/jm200364n PMID:21534605
- Uckun, F. M., Qazi, S., Ozer, Z., Garner, A. L., Pitt, J., Ma, H., Janda, K. D. Inducing apoptosis in chemotherapy-resistant B-lineage acute lymphoblastic leukaemia cells by targeting HSPA5, a master regulator of the anti-apoptotic unfolded protein response signalling network British Journal of Haematology 2011 153:741-752 DOI:10.1111/j.1365-2141.2011.08671.x PMID:21517817
- Kirchdoerfer, R. N., Garner, A. L., Flack, C. E., Mee, J. M., Horswill, A. R., Janda, K. D., Kaufmann, G. F., Wilson, I. A. Structural basis for ligand recognition and discrimination of a quorum-quenching antibody Journal of Biological Chemistry 2011 286:17351-17358 DOI:10.1074/jbc.M111.231258 PMID:21454495 PMCID:PMC3089576
- Moreno, A. Y., Mayorov, A. V., Janda, K. D. Impact of distinct chemical structures for the development of a methamphetamine vaccine Journal of the American Chemical Society 2011 133:6587-6595 DOI:10.1021/ja108807j PMID:21473576 PMCID:PMC3090292
- Treweek, J. B., Roberts, A. J., Janda, K. D. Immunopharmacotherapeutic manifolds and modulation of cocaine overdose Pharmacology, Biochemistry and Behavior 2011 98:474-484 DOI:10.1016/j.pbb.2011.02.020 PMID:21356233 PMCID:PMC3069656
- Garner, A. L., Yu, J., Struss, A. K., Lowery, C. A., Zhu, J., Kim, S. K., Park, J., Mayorov, A. V., Kaufmann, G. F., Kravchenko, V. V., Janda, K. D. Synthesis of 'clickable' acylhomoserine lactone quorum sensing probes: Unanticipated effects on mammalian cell activation Bioorganic & Medicinal Chemistry Letters 2011 21:2702-2705 DOI:10.1016/j.bmcl.2010.11.122 PMID:21190852 PMCID:PMC3081916
- Stowe, G. N., Janda, K. D. A Diels-Alder reaction conducted within the parameters of aqueous organocatalysis: Still just smoke and mirrors Tetrahedron Letters 2011 52:2085-2087 DOI:10.1016/j.tetlet.2010.10.134 PMID:21516231 PMCID:PMC3079225
- Silhar, P., Alakurtti, S., Caapkova, K., Feng, X. C., Shoemaker, C. B., Yli-Kauhaluoma, J., Janda, K. D. Synthesis and evaluation of library of betulin derivatives against the botulinum neurotoxin A protease Bioorganic & Medicinal Chemistry Letters 2011 21:2229-2231 DOI:10.1016/j.bmcl.2011.02.115 PMID:21421315 PMCID:PMC3070790
- Zakhari, J. S., Kinoyama, I., Struss, A. K., Pullanikat, P., Lowery, C. A., Lardy, M., Janda, K. D. Synthesis and molecular modeling provide insight into a Pseudomonas aeruginosa quorum sensing conundrum Journal of the American Chemical Society 2011 133:3840-3842 DOI:10.1021/ja111138y PMID:21348514 PMCID:PMC3060279
- Hicks, M. J., De, B. P., Rosenberg, J. B., Davidson, J. T., Moreno, A. Y., Janda, K. D., Wee, S., Koob, G. F., Hackett, N. R., Kaminsky, S. M., Worgall, S., Toth, M., et al. Cocaine analog coupled to disrupted adenovirus: A vaccine strategy to evoke high-titer immunity against addictive drugs Molecular Therapy 2011 19:612-619 DOI:10.1038/mt.2010.280 PMID:21206484 PMCID:PMC3048190
- Garner, A. L., Janda, K. D. Protein-protein interactions and cancer: targeting the central dogma Current Topics in Medicinal Chemistry 2011 11:258-280 DOI:10.2174/156802611794072614 PMID:21320057
- Johnson, E. A., Lin, G. Y., Pier, C. L., Barbieri, J. T., Janda, K. D., Chen, C., Pellett, S., Tepp, W. H. Botulinum neurotoxin subtype A2 enters neuronal cells faster than subtype A1 FEBS Letters 2011 585:199-206 DOI:10.1016/j.febslet.2010.11.045 PMID:21126520 PMCID:PMC3041152
- Salzameda, N. T., Eubanks, L. M., Zakhari, J. S., Tsuchikama, K., DeNunzio, N. J., Allen, K. N., Hixon, M. S., Janda, K. D. A cross-over inhibitor of the botulinum neurotoxin light chain B: A natural product implicating an exosite mechanism of action Chemical Communications 2011 47:1713-1715 DOI:10.1039/c0cc04078a PMID:21203627 PMCID:PMC3065946
- Garner, A. L., Janda, K. D. A small molecule antagonist of ghrelin O-acyltransferase (GOAT) Chemical Communications 2011 47:7512-7514 DOI:10.1039/c1cc11817j PMID:21594284
- Lowery, C. A., Kaufmann, G. F., Janda, K. D. Determination of acyl homoserine lactone and tetramic acid concentrations in biological samples Methods in Molecular Biology 2011 692:101-111 DOI:10.1007/978-1-60761-971-0_8 PMID:21031307
- Kaufmann, G. F., Park, J., Mayorov, A. V., Kubitz, D. M., Janda, K. D. Generation of quorum quenching antibodies Methods in Molecular Biology 2011 692:299-311 DOI:10.1007/978-1-60761-971-0_22 PMID:21031321
- Eubanks, L. M., Stowe, G. N., Marin, S. D., Mayorov, A. V., Hixon, M. S., Janda, K. D. Identification of alpha(2) macroglobulin as a major serum ghrelin esterase Angewandte Chemie-International Edition 2011 50:10699-10702 DOI:10.1002/anie.201104512 PMID:21928452 PMCID:PMC3515674
- Mayorov, A. V., Willis, B., Di Mola, A., Adler, D., Borgia, J., Jackson, O., Wang, J., Luo, Y. Y., Tang, L., Knapp, R. J., Natarajan, C., Goodnough, M. C., et al. Symptomatic relief of botulinum neurotoxin/a intoxication with aminopyridines: A new twist on an old molecule ACS Chemical Biology 2010 5:1183-1191 DOI:10.1021/cb1002366 PMID:20936877 PMCID:PMC3003761
- Lowery, C. A., Salzameda, N. T., Sawada, D., Kaufmann, G. F., Janda, K. D. Medicinal chemistry as a conduit for the modulation of quorum sensing Journal of Medicinal Chemistry 2010 53:7467-7489 DOI:10.1021/jm901742c PMID:20669927 PMCID:PMC2974035
- Treweek, J. B., Roberts, A. J., Janda, K. D. Superadditive effects of ethanol and flunitrazepam: Implications of using immunopharmacotherapy as a therapeutic Molecular Pharmaceutics 2010 7:2056-2068 DOI:10.1021/mp900293a PMID:20849117 PMCID:PMC2997924
- Eubanks, L. M., Silhar, P., Salzameda, N. T., Zakhari, J. S., Xiaochuan, F., Barbieri, J. T., Shoemaker, C. B., Hixon, M. S., Janda, K. D. Identification of a natural product antagonist against the botulinum neurotoxin light chain protease ACS Medicinal Chemistry Letters 2010 1:268-272 DOI:10.1021/ml100074s PMID:20959871 PMCID:PMC2955888
- Thyagarajan, B., Potian, J. G., Garcia, C. C., Hognason, K., Capkova, K., Moe, S. T., Jacobson, A. R., Janda, K. D., McArdle, J. J. Effects of hydroxamate metalloendoprotease inhibitors on botulinum neurotoxin a poisoned mouse neuromuscular junctions Neuropharmacology 2010 58:1189-1198 DOI:10.1016/j.neuropharm.2010.02.014 PMID:20211192 PMCID:PMC2867082
- Staflin, K., Krueger, J. S., Hachmann, J., Forsyth, J. S., Lorger, M., Steiniger, S. C. J., Mee, J., Pop, C., Salvesen, G. S., Janda, K. D., Felding-Habermann, B. Targeting activated integrin alpha v beta 3 with patient-derived antibodies impacts late-stage multiorgan metastasis Clinical & Experimental Metastasis 2010 27:217-231 DOI:10.1007/s10585-010-9320-5 PMID:20225083 PMCID:PMC4830478
- Silhar, P., Capkova, K., Salzameda, N. T., Barbieri, J. T., Hixon, M. S., Janda, K. D. Botulinum neurotoxin a protease: Discovery of natural product exosite inhibitors Journal of the American Chemical Society 2010 132:2868-2869 DOI:10.1021/ja910761y PMID:20158239 PMCID:PMC2832098
- Moreno, A. Y., Azar, M. R., Warren, N. A., Dickerson, T. J., Koob, G. F., Janda, K. D. A critical evaluation of a nicotine vaccine within a self-administration behavioral model Molecular Pharmaceutics 2010 7:431-441 DOI:10.1021/mp900213u PMID:20104903
- Gloeckner, C., Garner, A. L., Mersha, F., Oksov, Y., Tricoche, N., Eubanks, L. M., Lustigman, S., Kaufmann, G. F., Janda, K. D. Repositioning of an existing drug for the neglected tropical disease Onchocerciasis Proceedings of the National Academy of Sciences of the United States of America 2010 107:3424-3429 DOI:10.1073/pnas.0915125107 PMID:20142509 PMCID:PMC2840490
- Stowe, G. N., Silhar, P., Hixon, M. S., Silvaggi, N. R., Allen, K. N., Moe, S. T., Jacobson, A. R., Barbieri, J. T., Janda, K. D. Chirality holds the key for potent inhibition of the botulinum neurotoxin serotype A protease Organic Letters 2010 12:756-759 DOI:10.1021/ol902820z PMID:20092262 PMCID:PMC2821465
- Nakai, Y., Tepp, W. H., Janda, K. D., Johnson, E. A., Pellett, S. Toosendanin: Synthesis of the AB-ring and investigations of its anti-botulinum properties (part II) Bioorganic & Medicinal Chemistry 2010 18:1280-1287 DOI:10.1016/j.bmc.2009.12.030 PMID:20044261 PMCID:PMC2819598
- Barbieri, J. T., Pellett, S., Capkova, K., Hixon, M. S., Janda, K. D., Johnson, E. A. Benzylidene cyclopentenediones: First irreversible inhibitors against botulinum neurotoxin A's zinc endopeptidase Bioorganic & Medicinal Chemistry Letters 2010 20:206-208 DOI:10.1016/j.bmcl.2009.10.129 PMID:19914829 PMCID:PMC2818383
- Garner, A. L., Janda, K. D. Cat-ELCCA: A robust method to monitor the fattty acid acyltransferase activityy of Grehlin O-Acyltransferase (GOAT) Angewandte Chemie-International Edition 2010 49:9630-9634 DOI:10.1002/anie.201003387 PMID:20845345 PMCID:PMC3485397
- Fukuchi, K., Steiniger, S. C. J., Deryugina, E., Liu, Y., Lowery, C. A., Gloeckner, C., Zhou, B., Kaufmann, G. F., Quigley, J. P., Janda, K. D. Inhibition of tumor metastasis: functional immune modulation of the CUB domain containing protein 1 Molecular Pharmaceutics 2010 7:245-253 DOI:10.1021/mp900236t PMID:19916495 PMCID:PMC2815031
- Denery, J. R., Nunes, A. A. K., Hixon, M. S., Dickerson, T. J., Janda, K. D. Metabolomics-based discovery of diagnostic biomarkers for onchocerciasis PLoS Neglected Tropical Diseases 2010 4:e834 DOI:10.1371/journal.pntd.0000834 PMID:20957145 PMCID:PMC2950146
- Lowery, C. A., Abe, T., Park, J., Eubanks, L. M., Sawada, D., Kaufmann, G. F., Janda, K. D. Revisiting AI-2 quorum sensing inhibitors: Direct comparison of alkyl-DPD analogues and a natural product fimbrolide Journal of the American Chemical Society 2009 131:15584-15585 DOI:10.1021/ja9066783 PMID:19824634 PMCID:PMC2784249
- Salzameda, N. T., Barbieri, J. T., Janda, K. D. Synthetic substrate for application in both high and low throughput assays for botulinum neurotoxin B protease inhibitors Bioorganic & Medicinal Chemistry Letters 2009 19:5848-5850 DOI:10.1016/j.bmcl.2009.08.079 PMID:19747823 PMCID:PMC2753755
- Lowery, C. A., Park, J., Gloeckner, C., Meijler, M. M., Mueller, R. S., Boshoff, H. I., Ulrich, R. L., Barry, C. E., Bartlett, D. H., Kravchenko, V. V., Kaufmann, G. F., Janda, K. D. Defining the mode of action of tetramic acid antibacterials derived from Pseudomonas aeruginosa quorum sensing signals Journal of the American Chemical Society 2009 131:14473-14479 DOI:10.1021/ja9056079 PMID:19807189 PMCID:PMC2760024
- Capkova, K., Salzameda, N. T., Janda, K. D. Investigations into small molecule non-peptidic inhibitors of the botulinum neurotoxins Toxicon 2009 54:575-582 DOI:10.1016/j.toxicon.2009.03.016 PMID:19327377 PMCID:PMC2730986
- Frederick, M. O., Marin, S. D., Janda, K. D., Nicolaou, K. C., Dickerson, T. J. Monoclonal antibodies with orthogonal azaspiracid epitopes ChemBioChem 2009 10:1625-1629 DOI:10.1002/cbic.200900201 PMID:19492388 PMCID:PMC2750835
- Treweek, J. B., Dickerson, T. J., Janda, K. D. Drugs of abuse that mediate advanced glycation end product formation: A chemical link to disease pathology Accounts of Chemical Research 2009 42:659-669 DOI:10.1021/ar800247d PMID:19275211 PMCID:PMC2982794
- Sheng, J. W., Oyler, G., Zhou, B., Janda, K., Shoemaker, C. B. Identification and characterization of a novel cell-penetrating peptide Biochemical and Biophysical Research Communications 2009 382:236-240 DOI:10.1016/j.bbrc.2008.11.139 PMID:19084505 PMCID:PMC3006162
- Moreno, A. Y., Janda, K. D. Immunopharmacotherapy: Vaccination strategies as a treatment for drug abuse and dependence Pharmacology, Biochemistry and Behavior 2009 92:199-205 DOI:10.1016/j.pbb.2009.01.015 PMID:19350728 PMCID:PMC2768391
- Pires-Alves, M., Ho, M. F., Aberle, K. K., Janda, K. D., Wilson, B. A. Tandem fluorescent proteins as enhanced FRET-based substrates for botulinum neurotoxin activity Toxicon 2009 53:392-399 DOI:10.1016/j.toxicon.2008.12.016 PMID:19168088 PMCID:PMC2649687
- Janda, K. D., Fischer, A., Tepp, W. H., Eubanks, L. M., Clancy, C. M., Montal, M., Pellett, S., Johnson, E. A., Dickerson, T. J., Nakai, Y. Bimodal modulation of the botulinum neurotoxin protein-conducting channel Proceedings of the National Academy of Sciences of the United States of America 2009 106:1330-1335 DOI:10.1073/pnas.0812839106 PMID:19164566 PMCID:PMC2635780
- Dickerson, T. J., Janda, K. D., Tepp, W. H., Nakai, Y., Johnson, E. A. Function-oriented synthesis applied to the anti-botulinum natural product toosendanin Bioorganic & Medicinal Chemistry 2009 17:1152-1157 DOI:10.1016/j.bmc.2008.12.042 PMID:19131252 PMCID:PMC2661763
- Janda, K. D., Zhou, H. Y., Johnson, E. A., Pellett, S., Zhou, B. Selection and characterization of a human monoclonal neutralizing antibody for clostridium Botulinum Neurotoxin serotype B Bioorganic & Medicinal Chemistry Letters 2009 19:662-664 DOI:10.1016/j.bmcl.2008.12.055 PMID:19112017 PMCID:PMC2645068
- Treweek, J. B., Moreno, A. Y., Janda, K. D. SLEEPLESS-ness and insomnia in fruit flies Angewandte Chemie-International Edition 2009 48:438-440 DOI:10.1002/anie.200804552 PMID:19072956
- Treweek, J. B., Sun, C., Mayorov, A. V., Qi, L., Levy, C. L., Roberts, A. J., Dickerson, T. J., Janda, K. D. Prevention of drug-induced memory impairment by immunopharmacotherapy Journal of Medicinal Chemistry 2008 51:6866-6875 DOI:10.1021/jm800506v PMID:18921991 PMCID:PMC2661766
- Mayorov, A. V., Amara, N., Chang, J. Y., Moss, J. A., Hixon, M. S., Ruiz, D. I., Meijler, M. M., Zorrilla, E. P., Janda, K. D. Catalytic antibody degradation of ghrelin increases whole-body metabolic rate and reduces refeeding in fasting mice Proceedings of the National Academy of Sciences of the United States of America 2008 105:17487-17492 DOI:10.1073/pnas.0711808105 PMID:18981425 PMCID:PMC2582297
- Park, J., Dickerson, T. J., Janda, K. D. Major sperm protein as a diagnostic antigen for onchocerciasis Bioorganic & Medicinal Chemistry 2008 16:7206-7209 DOI:10.1016/j.bmc.2008.06.038 PMID:18632276
- Lowery, C. A., Park, J., Kaufmann, G. F., Janda, K. D. An unexpected switch in the modulation of AI-2-based quorum sensing discovered through synthetic 4,5-dihydroxy-2,3-pentanedione analogues Journal of the American Chemical Society 2008 130:9200-9201 DOI:10.1021/ja802353j PMID:18576653 PMCID:PMC2668569
- Kravchenko, V. V., Kaufmann, G. F., Mathison, J. C., Scott, D. A., Katz, A. Z., Grauer, D. C., Lehmann, M., Meijler, M. M., Janda, K. D., Ulevitch, R. J. Modulation of gene expression via disruption of NF-kappa B signaling by a bacterial small molecule Science 2008 321:259-263 DOI:10.1126/science.1156499 PMID:18566250
- Kaufmann, G. F., Park, J., Janda, K. D. Bacterial quorum sensing: A new target for anti-infective immunotherapy Expert Opinion on Biological Therapy 2008 8:719-724 DOI:10.1517/14712590802088006 PMID:18476783
- Janda, K. Instant insight - communicating with nature Chemistry World 2008 5:35-35
- Kaufmann, G. F., Park, J., Mee, J. M., Ulevitch, R. J., Janda, K. D. The quorum quenching antibody RS2-1G9 protects macrophages from the cytotoxic effects of the pseudomonas aeruginosa quorum sensing signalling molecule N-3-oxo-dodecanoyl-homoserine lactone Molecular Immunology 2008 45:2710-2714 DOI:10.1016/j.molimm.2008.01.010 PMID:18304641 PMCID:PMC2359578
- Zhou, B., Pellett, S., Johnson, E. A., Janda, K. D., Tepp, W. H., Zhou, H. Delineating the susceptibility of botulinum neurotoxins to denaturation through thermal effects FEBS Letters 2008 582:1526-1531 DOI:10.1016/j.febslet.2008.03.047 PMID:18396167
- Yoneda, Y., Steiniger, S. C. J., Capkova, K., Mee, J. M., Liu, Y., Kaufmann, G. F., Janda, K. D. A cell-penetrating peptidic GRP78 ligand for tumor cell-specific prodrug therapy Bioorganic & Medicinal Chemistry Letters 2008 18:1632-1636 DOI:10.1016/j.bmcl.2008.01.060 PMID:18243696 PMCID:PMC2288489
- Debler, E. W., Kaufmann, G. F., Meijler, M. M., Heine, A., Mee, J. M., Pljevaljcic, G., Di Bilio, A. J., Schultz, P. G., Millar, D. P., Janda, K. D., Wilson, I. A., Gray, H. B., et al. Deeply inverted electron-hole recombination in a luminescent antibody-stilbene complex Science 2008 319:1232-1235 DOI:10.1126/science.1153445 PMID:18309081
- Zhou, B., Carney, C., Janda, K. D. Selection and characterization of human antibodies neutralizing Bacillus anthracis toxin Bioorganic & Medicinal Chemistry 2008 16:1903-1913 DOI:10.1016/j.bmc.2007.11.001 PMID:18023190 PMCID:PMC2268906
- Willis, B., Eubanks, L. M., Wood, M. R., Janda, K. D., Dickerson, T. J., Lerner, R. A. Biologically templated organic polymers with nanoscale order Proceedings of the National Academy of Sciences of the United States of America 2008 105:1416-1419 DOI:10.1073/pnas.0711308105 PMID:18216240 PMCID:PMC2234158
- Zarebski, L. M., Vaughan, K., Sidney, J., Peters, B., Grey, H., Janda, K. D., Casadevall, A., Sette, A. Analysis of epitope information related to Bacillus anthracis and Clostridium botulinum Expert Review of Vaccines 2008 7:55-74 DOI:10.1586/14760584.7.1.55 PMID:18251694 PMCID:PMC3319117
- Richardson, H. N., Zhao, Y., Fekete, E. M., Funk, C. K., Wirsching, P., Janda, K. D., Zorrilla, E. P., Koob, G. F. MPZP: A novel small molecule corticotropin-releasing factor type 1 receptor (CRF1) antagonist Pharmacology, Biochemistry and Behavior 2008 88:497-510 DOI:10.1016/j.pbb.2007.10.008 PMID:18031798 PMCID:PMC3319109
- Lowery, C. A., Dickerson, T. J., Janda, K. D. Interspecies and interkingdom communication mediated by bacterial quorum sensing Chemical Society Reviews 2008 37:1337-1346 DOI:10.1039/b702781h PMID:18568160
- Steiniger, S. C. J., Coppinger, J. A., Kruger, J. A., Yates, J., Janda, K. D. Quantitative mass spectrometry identifies drug targets in cancer stem cell-containing side population Stem Cells 2008 26:3037-3046 DOI:10.1634/stemcells.2008-0397 PMID:18802034 PMCID:PMC2745975
- Park, J., Kaufmann, G. F., Bowen, J. P., Arbiser, J. L., Janda, K. D. Solenopsin A, a venom alkaloid from the fire ant Solenopsis invicta, inhibits quorum-sensing signaling in Pseudomonas aeruginosa Journal of Infectious Diseases 2008 198:1198-1201 DOI:10.1086/591916 PMID:18713055
- Willis, B., Eubanks, L. M., Dickerson, T. J., Janda, K. D. The strange case of the botulinum neurotoxin: Using chemistry and bilogy to modulate the most deadly poison Angewandte Chemie-International Edition 2008 47:8360-8379 DOI:10.1002/anie.200705531 PMID:18844202
- Capkova, K., Hixon, M. S., McAllister, L. A., Janda, K. D. Toward the discovery of potent inhibitors of botulinum neurotoxin a: Development of a robust lc ms based assay operational from low to subnanomolar enzyme concentrations Chemical Communications 2008 3525-3527 DOI:10.1039/b808305c PMID:18654701
- Brogan, A. P., Dickerson, T. J., Janda, K. D. Noirnicotine-organocatalyzed aqueous reduction of alpha,beta-unsaturated aldehydes Chemical Communications 2007 4952-4954 DOI:10.1039/b713273e PMID:18361380
- Capkova, K., Yoneda, Y., Dickerson, T. J., Janda, K. D. Synthesis and structure-activity relationships of second-generation hydroxamate botulinum neurotoxin A protease inhibitors Bioorganic & Medicinal Chemistry Letters 2007 17:6463-6466 DOI:10.1016/j.bmcl.2007.09.103 PMID:17951059 PMCID:PMC2170532
- Zhou, H. Y., Zhou, B., Ma, H. Z., Carney, C., Janda, K. D. Selection and characterization of human monoclonal antibodies against Abrin by phage display Bioorganic & Medicinal Chemistry Letters 2007 17:5690-5692 DOI:10.1016/j.bmcl.2007.07.053 PMID:17764932
- Park, J., Jagasia, R., Kaufmann, G. F., Mathison, J. C., Ruiz, D. I., Moss, J. A., Meijler, M. M., Ulevitch, R. J., Janda, K. D. Infection control by antibody disruption of bacterial quorum sensing signaling Chemistry & Biology 2007 14:1119-1127 DOI:10.1016/j.chembiol.2007.08.013 PMID:17961824 PMCID:PMC2088803
- Xu, Y., Hixon, M. S., Dawson, P. E., Janda, K. D. Development of a FRET assay for monitoring of HIV gp41 core disruption Journal of Organic Chemistry 2007 72:6700-6707 DOI:10.1021/jo070836l PMID:17685571
- Ino, A., Dickerson, T. J., Janda, K. D. Positional linker effects in haptens for cocaine immunopharmacotherapy Bioorganic & Medicinal Chemistry Letters 2007 17:4280-4283 DOI:10.1016/j.bmcl.2007.05.032 PMID:17531484
- Dickerson, T. J., McKenzie, K. M., Hoyt, A. S., Wood, M. R., Janda, K. D., Brenner, S. B., Lerner, R. A. Phage escape libraries for checkmate analysis Proceedings of the National Academy of Sciences of the United States of America 2007 104:12703-12708 DOI:10.1073/pnas.0705362104 PMID:17646645 PMCID:PMC1937530
- Treweek, J., Wee, S., Koob, G. F., Dickerson, T. J., Janda, K. D. Self-vaccination by methamphetamine glycation products chemically links chronic drug abuse and cardiovascular disease Proceedings of the National Academy of Sciences of the United States of America 2007 104:11580-11584 DOI:10.1073/pnas.0701328104 PMID:17592122 PMCID:PMC1913859
- Debler, E. W., Kaufmann, G. F., Kirchdoerfer, R. N., Mee, J. M., Janda, K. D., Wilson, I. A. Crystal structures of a quorum-quenching antibody Journal of Molecular Biology 2007 368:1392-1402 DOI:10.1016/j.jmb.2007.02.081 PMID:17400249 PMCID:PMC1994716
- Liu, Y., Steiniger, S. C. J., Kim, Y., Kaufmann, G. F., Felding-Habermann, B., Janda, K. D. Mechanistic studies of a peptidic GRP78 ligand for cancer cell-specific drug delivery Molecular Pharmaceutics 2007 4:435-447 DOI:10.1021/mp060122j PMID:17373820 PMCID:PMC2533281
- Silvaggi, N. R., Boldt, G. E., Hixon, M. S., Kennedy, J. P., Tzipori, S., Janda, K. D., Allen, K. N. Structures of clostridium botulinum neurotoxin serotype A light chain complexed with small-molecule inhibitors highlight active-site flexibility Chemistry & Biology 2007 14:533-542 DOI:10.1016/j.chembiol.2007.03.014 PMID:17524984
- Steiniger, S. C. J., Altobell, L. J., Zhou, B., Janda, K. D. Selection of human antibodies against cell surface-associated oligomeric anthrax protective antigen Molecular Immunology 2007 44:2749-2755 DOI:10.1016/j.molimm.2006.11.011 PMID:17210180
- Brogan, A. P., Eubanks, L. M., Koob, G. F., Dickerson, T. J., Janda, K. D. Antibody-catalyzed oxidation of delta(9)-tetrahydrocannabinol Journal of the American Chemical Society 2007 129:3698-3702 DOI:10.1021/ja070022m PMID:17335216
- Marin, S. D., Xu, Y., Meijler, M. M., Janda, K. D. Antibody catalyzed hydrolysis of a quorum sensing signal found in gram-negative bacteria Bioorganic & Medicinal Chemistry Letters 2007 17:1549-1552 DOI:10.1016/j.bmcl.2006.12.118 PMID:17254784
- Xu, Y., Hixon, M. S., Yamamoto, N., McAllister, L. A., Wentworth, A. D., Wentworth, P., Janda, K. D. Antibody-catalyzed anaerobic destruction of methamphetamine Proceedings of the National Academy of Sciences of the United States of America 2007 104:3681-3686 DOI:10.1073/pnas.0611094104 PMID:17360412 PMCID:PMC1820643
- McAllister, L. A., Hixon, M. S., Schwartz, R., Kubitz, D. S., Janda, K. D. Synthesis and application of a novel ligand for affinity chromatography based removal of endotoxin from antibodies Bioconjugate Chemistry 2007 18:559-566 DOI:10.1021/bc0602984 PMID:17315943
- McKenzie, K. M., Mee, J. M., Rogers, C. J., Hixon, M. S., Kaufmann, G. F., Janda, K. D. Identification and characterization of single chain anti-cocaine catalytic antibodies Journal of Molecular Biology 2007 365:722-731 DOI:10.1016/j.jmb.2006.10.031 PMID:17084858 PMCID:PMC1828637
- Dickerson, T. J., Clancy, C. M., Johnson, E. A., Baldwin, M. R., Jin, W., Barbieri, J. T., Tepp, W. H., Eubanks, L. M., Malizio, C. J., Goodnough, M. C., Janda, K. D., Hong, S., et al. An in vitro and in vivo disconnect uncovered through high-throughput identification of botulinum neurotoxin A antagonists Proceedings of the National Academy of Sciences of the United States of America 2007 104:2602-2607 DOI:10.1073/pnas.0611213104 PMID:17293454 PMCID:PMC1815229
- Eubanks, L. M., Dickerson, T. J., Janda, K. D. Technological advancements for the detection of and protection against biological and chemical warfare agents Chemical Society Reviews 2007 36:458-470 DOI:10.1039/b615227a PMID:17325785
- Rogers, C. J., Eubanks, L. M., Dickerson, T. J., Janda, K. D. Unexpected acetylcholinesterase activity of cocaine esterases Journal of the American Chemical Society 2006 128:15364-15365 DOI:10.1021/ja066241+ PMID:17131989 PMCID:PMC2533137
- Eubanks, L. M., Rogers, C. J., Beuscher, A. E., Koob, G. F., Olson, A. J., Dickerson, T. J., Janda, K. D. A molecular link between the active component of marijuana and Alzheimer's disease pathology Molecular Pharmaceutics 2006 3:773-777 DOI:10.1021/mp060066m PMID:17140265 PMCID:PMC2562334
- Kravchenko, V. V., Kaufmann, G. F., Mathison, J. C., Scott, D. A., Katz, A. Z., Wood, M. R., Brogan, A. P., Lehmann, M., Mee, J. M., Iwata, K., Pan, Q., Fearns, C., et al. N-(3-oxo-acyl)homoserine lactones signal cell activation through a mechanism distinct from the canonical pathogen-associated molecular pattern recognition receptor pathways Journal of Biological Chemistry 2006 281:28822-28830 DOI:10.1074/jbc.M606613200 PMID:16893899
- Zorrilla, E. P., Iwasaki, S., Moss, J. A., Chang, J., Otsuji, J., Inoue, K., Meijler, M. M., Janda, K. D. Vaccination against weight gain Proceedings of the National Academy of Sciences of the United States of America 2006 103:13226-13231 DOI:10.1073/pnas.0605376103 PMID:16891413 PMCID:PMC1559781
- Kim, Y., Lillo, A. M., Steiniger, S. C. J., Liu, Y., Ballatore, C., Anichini, A., Mortarini, R., Kaufmann, G. F., Zhou, B., Felding-Habermann, B., Janda, K. D. Targeting heat shock proteins on cancer cells: Selection, characterization, and cell-penetrating properties of a peptidic GRP78 ligand Biochemistry 2006 45:9434-9444 DOI:10.1021/bi060264j PMID:16878978
- Fu, Z. J., Chen, S., Baldwin, M. R., Boldt, G. E., Crawford, A., Janda, K. D., Barbieri, J. T., Kim, J. J. P. Light chain of botulinum neurotoxin serotype A: Structural resolution of a catalytic intermediate Biochemistry 2006 45:8903-8911 DOI:10.1021/bi060786z PMID:16846233
- Xu, Y., Lu, H., Kennedy, J. P., Yan, X. X., McAllister, L. A., Yamamoto, N., Moss, J. A., Boldt, G. E., Jiang, S. B., Janda, K. D. Evaluation of "credit card" libraries for inhibition of HIV-1 gp41 fusogenic core formation Journal of Combinatorial Chemistry 2006 8:531-539 DOI:10.1021/cc0600167 PMID:16827565 PMCID:PMC2529179
- Boldt, G. E., Kennedy, J. P., Hixon, M. S., McAllister, L. A., Barbieri, J. T., Tzipori, S., Janda, K. D. Synthesis, characterization and development of a high-throughput methodology for the discovery of botulinum neurotoxin A inhibitors Journal of Combinatorial Chemistry 2006 8:513-521 DOI:10.1021/cc060010h PMID:16827563 PMCID:PMC2644723
- Ma, H. Z., Zhou, B., Kim, Y., Janda, K. D. A cyclic peptide-polymer probe for the detection of Clostridium botulinum neurotoxin serotype A Toxicon 2006 47:901-908 DOI:10.1016/j.toxicon.2006.03.003 PMID:16730044
- Xu, Y., Shi, J., Yamamoto, N., Moss, J. A., Vogt, P. K., Janda, K. D. A credit-card library approach for disrupting protein-protein interactions Bioorganic & Medicinal Chemistry 2006 14:2660-2673 DOI:10.1016/j.bmc.2005.11.052 PMID:16384710
- Boldt, G. E., Kennedy, J. P., Janda, K. D. Identification of a potent botulinum neurotoxin a protease inhibitor using in situ lead identification chemistry Organic Letters 2006 8:1729-1732 DOI:10.1021/ol0603211 PMID:16597152 PMCID:PMC2733786
- McAllister, L. A., Hixon, M. S., Kennedy, J. P., Dickerson, T. J., Janda, K. D. Superactivation of the botulinum neurotoxin serotype A light chain metalloprotease: A new wrinkle in botulinum neurotoxin Journal of the American Chemical Society 2006 128:4176-4177 DOI:10.1021/ja057699z PMID:16568962 PMCID:PMC2529174
- Moss, J. A., Stokols, S., Hixon, M. S., Ashley, F. T., Chang, J. Y., Janda, K. D. Solid-phase synthesis and kinetic characterization of fluorogenic enzyme-degradable hydrogel cross-linkers Biomacromolecules 2006 7:1011-1016 DOI:10.1021/bm051001s PMID:16602715 PMCID:PMC2546486
- Kaufmann, G. F., Sartorio, R., Lee, S. H., Mee, J. M., Altobell, L. J., Kujawa, D. P., Jeffries, E., Clapham, B., Meijler, M. M., Janda, K. D. Antibody interference with N-acyl homoserine lactone-mediated bacterial quorum sensing Journal of the American Chemical Society 2006 128:2802-2803 DOI:10.1021/ja0578698 PMID:16506750 PMCID:PMC2546487
- Shigenaga, A., Moss, J. A., Ashley, F. T., Kaufmann, G. F., Janda, K. D. Solid-phase synthesis and cyclative cleavage of quorum sensing depsipeptide analogues by acylphenyldiazene activation Synlett 2006 551-554 DOI:10.1055/s-2006-9325468
- Zhu, X. Y., Dickerson, T. J., Rogers, C. J., Kaufmann, G. F., Mee, J. M., McKenzie, K. M., Janda, K. D., Wilson, I. A. Complete reaction cycle of a cocaine catalytic antibody at atomic resolution Structure 2006 14:205-216 DOI:10.1016/j.str.2005.10.014 PMID:16472740
- Boldt, G. E., Dickerson, T. J., Janda, K. D. Emerging chemical and biological approaches for the preparation of discovery libraries Drug Discovery Today 2006 11:143-148 DOI:10.1016/s1359-6446(05)03697-4 PMID:16533712
- Zhang, L. G., Long, H., Boldt, G. E., Janda, K. D., Schatz, G. C., Lewis, F. D. α- and β-Stilbenosides as base-pair surrogates in DNA hairpins Organic & Biomolecular Chemistry 2006 4:314-322 DOI:10.1039/b513694f PMID:16391774
- Wu, W. Y., Luo, Y. P., Sun, C. Z., Liu, Y. A., Kuo, P., Varga, J., Xiang, R., Reisfeld, R., Janda, K. D., Edgington, T. S., Liu, C. Targeting cell-impermeable prodrug activation to tumor microenvironment eradicates multiple drug-resistant neoplasms Cancer Research 2006 66:970-980 DOI:10.1158/0008-5472.can-05-2591 PMID:16424032
- Rogers, C. J., Dickerson, T. J., Janda, K. D. Kinetic isotope and thermodynamic analysis of the nornicotine-catalyzed aqueous aldol reaction Tetrahedron 2006 62:352-356 DOI:10.1016/j.tet.2005.09.094
- Boldt, G. E., Eubanks, L. M., Janda, K. D. Identification of A botulinum neurotoxin a protease inhibitor displaying efficacy in a cellular model Chemical Communications 2006 3063-3065 DOI:10.1039/b603099h PMID:16855686
- Dickerson, T. J., Janda, K. D. The use of small molecules to investigate molecular mechanisms and therapeutic targets for treatment of botulinum neurotoxin A intoxication ACS Chemical Biology 2006 1:359-369 DOI:10.1021/cb600179d PMID:17163773
- Rogers, C. J., Dickerson, T. J., Wentworth, P., Janda, K. D. A high-swelling reagent scaffold suitable for use in aqueous and organic solvents Tetrahedron 2005 61:12140-12144 DOI:10.1016/j.tet.2005.07.115
- Shimomura, O., Lee, B. S., Meth, S., Suzuki, H., Mahajan, S., Nomura, R., Janda, K. D. Synthesis and application of polytetrahydrofuran-grafted polystyrene (PS-PTHF) resin supports for organic synthesis Tetrahedron 2005 61:12160-12167 DOI:10.1016/j.tet.2005.08.121
- Qi, L. W., Yamamoto, N., Meijler, M. M., Altobell, L. J., Koob, G. F., Wirsching, P., Janda, K. D. Delta(9)-tetrahydrocannabinol immunochemical studies: Haptens, monoclonal antibodies, and a convenient synthesis of radiolabeled delta(9)-tetrahydrocannabinol Journal of Medicinal Chemistry 2005 48:7389-7399 DOI:10.1021/jm050442r PMID:16279798
- Dickerson, T. J., Beuscher, A. E., Hixon, M. S., Yamamoto, N., Xu, Y., Olson, A. J., Janda, K. D. Discovery of acetylcholinesterase peripheral anionic site ligands through computational refinement of a directed library Biochemistry 2005 44:14845-14853 DOI:10.1021/bi051613x PMID:16274232
- Kim, Y., Lillo, A., Moss, J. A., Janda, K. D. A contiguous stretch of methionine residues mediates the energy-dependent internalization mechanism of a cell-penetrating peptide Molecular Pharmaceutics 2005 2:528-535 DOI:10.1021/mp050035b PMID:16323960
- Shute, T. S., Matsushita, M., Dickerson, T. J., La Clair, J. J., Janda, K. D., Burkart, M. D. A site-specific bifunctional protein labeling system for affinity and fluorescent analysis Bioconjugate Chemistry 2005 16:1352-1355 DOI:10.1021/bc050213j PMID:16287229
- Matsushita, M., Meijler, M. M., Wirsching, P., Lerner, R. A., Janda, K. D. A blue fluorescent anti body-cofactor sensor for mercury Organic Letters 2005 7:4943-4946 DOI:10.1021/ol051919w PMID:16235928
- Eubanks, L. M., Dickerson, T. J., Janda, K. D. Vitamin B-2-mediated cellular photoinhibition of botulinum neurotoxin A FEBS Letters 2005 579:5361-5364 DOI:10.1016/j.febslet.2005.08.072 PMID:16198354
- Matsushita, H., Yamamoto, N., Meijler, M. M., Wirsching, P., Lerner, R. A., Matsushita, M., Janda, K. D. Chiral sensing using a blue fluorescent antibody Molecular Biosystems 2005 1:303-306 DOI:10.1039/b511408j PMID:16880995
- Xu, Y., Yamamoto, N., Ruiz, D. I., Kubitz, D. S., Janda, K. D. Squaric monoamide monoester as a new class of reactive immunization hapten for catalytic antibodies Bioorganic & Medicinal Chemistry Letters 2005 15:4304-4307 DOI:10.1016/j.bmcl.2005.06.052 PMID:16046128
- Toker, J. D., Tremblay, M. R., Yli-Kauhaluoma, J., Wentworth, A. D., Zhou, B., Wentworth, P., Janda, K. D. Exploring the scope of the 29g12 antibody catalyzed 1,3-dipolar cycloaddition reaction Journal of Organic Chemistry 2005 70:7810-7815 DOI:10.1021/jo050410b PMID:16277300
- Yamashita, M., Lee, S. H., Koch, G., Zimmermann, J., Clapham, B., Janda, K. D. Solid-phase synthesis of oxazolones and other heterocycles via wang resin-bound diazocarbonyls Tetrahedron Letters 2005 46:5495-5498 DOI:10.1016/j.tetlet.2005.06.061
- Carrera, M. R. A., Trigo, J. M., Wirsching, P., Roberts, A. J., Janda, K. D. Evaluation of the anticocaine monoclonal antibody GNC92H2 as an immunotherapy for cocaine overdose Pharmacology, Biochemistry and Behavior 2005 81:709-714 DOI:10.1016/j.pbb.2005.04.018 PMID:16005948
- Brogan, A. P., Dickerson, T. J., Boldt, G. E., Janda, K. D. Altered retinoid homeostasis catalyzed by a nicotine metabolite: Implications in macular degenerationand and normal development Proceedings of the National Academy of Sciences of the United States of America 2005 102:10433-10438 DOI:10.1073/pnas.0504721102 PMID:16014706 PMCID:PMC1180800
- Rogers, C. J., Mee, J. M., Kaufmann, G. F., Dickerson, T. J., Janda, K. D. Toward cocaine esterase therapeutics Journal of the American Chemical Society 2005 127:10016-10017 DOI:10.1021/ja053086a PMID:16011362 PMCID:PMC1352337
- Lee, B. S., Mahajan, S., Janda, K. D. Asymmetric dihydroxylation catalyzed by ionic polymer-supported osmium tetroxide Tetrahedron Letters 2005 46:4491-4493 DOI:10.1016/j.tetlet.2005.04.113
- Dickerson, T. J., Kaufmann, G. F., Janda, K. D. Bacteriophage-mediated protein delivery into the central nervous system and its application in immunopharmacotherapy Expert Opinion on Biological Therapy 2005 5:773-781 DOI:10.1517/14712598.5.6.773 PMID:15952908
- Lee, B. S., Mahajan, S., Janda, K. D. Molecular iodine-catalyzed imine activation for three-component nucleophilic addition reactions Synlett 2005 1325-1327 DOI:10.1055/s-2005-838487
- Lowery, C. A., McKenzie, K. M., Qi, L. W., Meijler, M. M., Janda, K. D. Quorum sensing in Vibrio harveyi: Probing the specificity of the LuxP binding site Bioorganic & Medicinal Chemistry Letters 2005 15:2395-2398 DOI:10.1016/j.bmcl.2005.02.069 PMID:15837332
- Rogers, C. J., Dickerson, T. J., Brogan, A. P., Janda, K. D. Hammett correlation of nornicotine analogues in the aqueous aldol reaction: Implications for green organocatalysis Journal of Organic Chemistry 2005 70:3705-3708 DOI:10.1021/jo050161r PMID:15845010
- Lee, B. S., Mahajan, S., Janda, K. D. Cross-linked poly(4-vinylpyridine/styrene) copolymers as a support for immobilization of ytterbium triflate Tetrahedron 2005 61:3081-3086 DOI:10.1016/j.tet.2005.01.068
- Reed, N. N., Dickerson, T. J., Boldt, G. E., Janda, K. D. Enantioreversal in the sharpless asymmetric epoxidation reaction controlled by the molecular weight of a covalently appended achiral polymer Journal of Organic Chemistry 2005 70:1728-1731 DOI:10.1021/jo048009x PMID:15730294
- Meijler, M. M., Kaufmann, G. F., Qi, L. W., Mee, J. M., Coyle, A. R., Moss, J. A., Wirsching, P., Matsushita, M., Janda, K. D. Fluorescent cocaine probes: A tool for the selection and engineering of therapeutic antibodies Journal of the American Chemical Society 2005 127:2477-2484 DOI:10.1021/ja043935e PMID:15725002
- Lee, B. S., Mahajan, S., Janda, K. D. Novel method for catalyst immobilization using an ionic polymer: A case study using recyclable ytterbium triflate Tetrahedron Letters 2005 46:807-810 DOI:10.1016/j.tetlet.2004.12.013
- Moss, J. A., Lillo, A., Kim, Y., Gao, C., Ditzel, H., Janda, K. D. A dimerization "switch" in the internalization mechanism of a cell-penetrating peptide Journal of the American Chemical Society 2005 127:538-539 DOI:10.1021/ja0443171 PMID:15643874
- Kaufmann, G. F., Sartorio, R., Lee, S. H., Rogers, C. J., Meijler, M. M., Moss, J. A., Clapham, B., Brogan, A. P., Dickerson, T. J., Janda, K. D. Revisiting quorum sensing: Discovery of additional chemical and biological functions for 3-oxo-N-acylhomoserine lactones Proceedings of the National Academy of Sciences of the United States of America 2005 102:309-314 DOI:10.1073/pnas.0408639102 PMID:15623555 PMCID:PMC544315
- McKenzie, K. M., Meijler, M. M., Lowery, C. A., Boldt, G. E., Janda, K. D. A furanosyl-carbonate autoinducer in cell-to-cell communication of v-harveyi Chemical Communications 2005 4863-4865 DOI:10.1039/b509396a
- Kaufmann, G. F., Meijler, M. M., Sun, C. Z., Chen, D. W., Kujawa, D. P., Mee, J. M., Hoffman, T. Z., Wirsching, P., Lerner, R. A., Janda, K. D. Enzymatic incorporation of an antibody-activated blue fluorophore into DNA Angewandte Chemie-International Edition 2005 44:2144-2148 DOI:10.1002/anie.200461143 PMID:15742317
- Dickerson, T. J., Reed, N. N., LaClair, J. J., Janda, K. D. A precipitator for the detection of thiophilic metals in aqua Journal of the American Chemical Society 2004 126:16582-16586 DOI:10.1021/ja045798r PMID:15600364
- Lee, S. H., Yoshida, K., Matsushita, H., Clapham, B., Koch, G., Zimmermann, J., Janda, K. D. N-H insertion reactions of primary ureas: The synthesis of highly substituted imidazolones and imidazoles from diazocarbonyls Journal of Organic Chemistry 2004 69:8829-8835 DOI:10.1021/jo048353u PMID:15575764
- Felding-Habermann, B., Lerner, R. A., Lillo, A., Zhuang, S. F., Weber, M. R., Arrues, S., Gao, C., Mao, S. L., Saven, A., Janda, K. D. Combinatorial antibody libraries from cancer patients yield ligand-mimetic Arg-Gly-Asp-containing immunoglobulins that inhibit breast cancer metastasis Proceedings of the National Academy of Sciences of the United States of America 2004 101:17210-17215 DOI:10.1073/pnas.0407869101 PMID:15563590 PMCID:PMC534417
- Matsushita, H., Lee, S. H., Yoshida, K., Clapham, B., Koch, G., Zimmermann, J., Janda, K. D. N-H insertion reactions of Boc-amino acid amides: Solution- and solid-phase synthesis of pyrazinones and pyrazines Organic Letters 2004 6:4627-4629 DOI:10.1021/ol047933a PMID:15548092
- Kim, Y., Moss, J. A., Janda, K. D. Biological tuning of synthetic tactics in solid-phase synthesis: Application to A beta(1-42) Journal of Organic Chemistry 2004 69:7776-7778 DOI:10.1021/jo048922y PMID:15498016
- Xu, Y., Yamamoto, N., Janda, K. D. Catalytic antibodies: Hapten design strategies and screening methods Bioorganic & Medicinal Chemistry 2004 12:5247-5268 DOI:10.1016/j.bmc.2004.03.077 PMID:15388154
- Carrera, M. R. A., Meijler, M. M., Janda, K. D. Cocaine pharmacology and current pharmacothetherapies for its abuse Bioorganic & Medicinal Chemistry 2004 12:5019-5030 DOI:10.1016/j.bmc.2004.06.018 PMID:15351386
- Dickerson, T. J., Lovell, T., Meijler, M. M., Noodleman, L., Janda, K. D. Nornicotine aqueous aldol reactions: synthetic and theoretical investigations into the origins of catalysis Journal of Organic Chemistry 2004 69:6603-6609 DOI:10.1021/jo048894j PMID:15387581
- Dickerson, T. J., Yamamoto, N., Ruiz, D. I., Janda, K. D. Immunological consequences of methamphetamine protein glycation Journal of the American Chemical Society 2004 126:11446-11447 DOI:10.1021/ja047690h PMID:15366884
- Dickerson, T. J., Yamamoto, N., Janda, K. D. Antibody-catalyzed oxidative degradation of nicotine using riboflavin Bioorganic & Medicinal Chemistry 2004 12:4981-4987 DOI:10.1016/j.bmc.2004.07.006 PMID:15336277
- Lee, S. H., Matsushita, H., Koch, G., Zimmermann, J., Clapham, B., Janda, K. D. Smart cleavage reactions: The synthesis of an array of ureas from polymer-bound carbamates Journal of Combinatorial Chemistry 2004 6:822-827 DOI:10.1021/cc049916i PMID:15360219
- Carrera, M. R. A., Kaufmann, G. F., Mee, J. M., Meijler, M. M., Koob, G. F., Janda, K. D. Treating cocaine addiction with viruses Proceedings of the National Academy of Sciences of the United States of America 2004 101:10416-10421 DOI:10.1073/pnas.0403795101 PMID:15226496 PMCID:PMC478586
- Lillo, A. M., Sun, C. Z., Gao, C., Ditzel, H., Parrish, J., Gauss, C. M., Moss, J., Felding-Habermann, B., Wirsching, P., Boger, D. L., Janda, K. D. A human single-chain antibody specific for integrin alpha(3)beta(1) capable of cell internalization and delivery of antitumor agents Chemistry & Biology 2004 11:897-906 DOI:10.1016/j.chembiol.2004.04.018 PMID:15271348
- Lee, B. S., Mahajan, S., Clapham, B., Janda, K. D. Suspension ring-opening metathesis polymerization: The preparation of norbornene-based resins for application in organic synthesis Journal of Organic Chemistry 2004 69:3319-3329 DOI:10.1021/jo049827s PMID:15132537
- Qi, L. W., Meijler, M. M., Lee, S. H., Sun, C. Z., Janda, K. D. Solid-phase synthesis of anandamide analogues Organic Letters 2004 6:1673-1675 DOI:10.1021/ol049474j PMID:15128264
- Lee, S. H., Matsushita, H., Clapham, B., Janda, K. D. The direct conversion of carbamates to ureas using aluminum amides Tetrahedron 2004 60:3439-3443 DOI:10.1016/j.tet.2004.02.034
- Meijler, M. M., Hom, L. G., Kaufmann, G. F., McKenzie, K. M., Sun, C. Z., Moss, J. A., Matsushita, M., Janda, K. D. Synthesis and biological validation of a ubiquitous quorum-sensing molecule Angewandte Chemie-International Edition 2004 43:2106-2108 DOI:10.1002/anie.200353150 PMID:15083457
- Ahn, J. M., Wentworth, P., Janda, K. D. Probing lipase/esterase libraries for lipid A hydrolases - discovery of biocatalysts for the detoxification of bacterially-expressed recombinant protein Chemical Communications 2004 364-365 DOI:10.1039/b312662e
- Carrera, M. R. A., Ashley, J. A., Hoffman, T. Z., Isomura, S., Wirsching, P., Koob, G. F., Janda, K. D. Investigations using immunization to attenuate the psychoactive effects of nicotine Bioorganic & Medicinal Chemistry 2004 12:563-570 DOI:10.1016/j.bmc.2003.11.029 PMID:14738965
- Matsushita, H., Lee, S. H., Joung, M., Clapham, B., Janda, K. D. Smart cleavage reactions: The synthesis of benzimidazoles and benzothiazoles from polymer-bound esters Tetrahedron Letters 2004 45:313-316 DOI:10.1016/j.tetlet.2003.10.168
- Dickerson, T. J., Tremblay, M. R., Hoffman, T. Z., Ruiz, D. I., Janda, K. D. Catalysis of the photo-Fries reaction: Antibody-mediated stabilization of high energy states Journal of the American Chemical Society 2003 125:15395-15401 DOI:10.1021/ja038016n PMID:14664584
- Chen, Y. P., Gambs, C., Abe, Y., Wentworth, P., Janda, K. D. Total synthesis of the depsipeptide FR-901375 Journal of Organic Chemistry 2003 68:8902-8905 DOI:10.1021/jo034765b PMID:14604360
- Wentworth, P., Nieva, J., Takeuchi, C., Galve, R., Wentworth, A. D., Dilley, R. B., DeLaria, G. A., Saven, A., Babior, B. M., Janda, K. D., Eschenmoser, A., Lerner, R. A. Evidence for ozone formation in human atherosclerotic arteries Science 2003 302:1053-1056 DOI:10.1126/science.1089525 PMID:14605372
- Moss, J. A., Coyle, A. R., Ahn, J. M., Meijler, M. M., Offer, J., Janda, K. D. Tandem IMAC-HPLC purification of a cocaine-binding scFv antibody Journal of Immunological Methods 2003 281:143-148 DOI:10.1016/j.jim.2003.07.010 PMID:14580888
- Fujimori, T., Wirsching, P., Janda, K. D. Preparation of a Krohnke pyridine combinatorial library suitable for solution-phase biological screening Journal of Combinatorial Chemistry 2003 5:625-631 DOI:10.1021/cc0300208
- Dickerson, T. J., Janda, K. D. Glycation of the amyloid beta-protein by a nicotine metabolite: A fortuitous chemical dynamic between smoking and Alzheimer's disease Proceedings of the National Academy of Sciences of the United States of America 2003 100:8182-8187 DOI:10.1073/pnas.1332847100 PMID:12815102 PMCID:PMC166203
- Meijler, M. M., Matsushita, M., Altobelli, L. J., Wirsching, P., Janda, K. D. A new strategy for improved nicotine vaccines using conformationally constrained haptens Journal of the American Chemical Society 2003 125:7164-7165 DOI:10.1021/ja034805t PMID:12797775
- Redwan, E. R. M., Larsen, N. A., Zhou, B., Wirsching, P., Janda, K. D., Wilson, I. A. Expression and characterization of a humanized cocaine-binding antibody Biotechnology and Bioengineering 2003 82:612-618 DOI:10.1002/bit.10598 PMID:12652485
- Liu, C., Sun, C. Z., Huang, H. N., Janda, K., Edgington, T. Overexpression of legumain in tumors is significant for invasion/metastasis and a candidate enzymatic target for prodrug therapy Cancer Research 2003 63:2957-2964 PMID:12782603
- Zhu, X. Y., Heine, A., Monnat, F., Houk, K. N., Janda, K. D., Wilson, I. A. Structural basis for antibody catalysis of a cationic cyclization reaction Journal of Molecular Biology 2003 329:69-83 DOI:10.1016/s0022-2836(03)00406-6 PMID:12742019
- Gambs, C., Dickerson, T. J., Mahajan, S., Pasternack, L. B., Janda, K. D. High-resolution diffusion-ordered spectroscopy to probe the microenvironment of JandaJel and Merrifield resins Journal of Organic Chemistry 2003 68:3673-3678 DOI:10.1021/jo034152z PMID:12713377
- Sun, C. Z., Wirsching, P., Janda, K. D. Enabling ScFvs as multi-drug carriers: A dendritic approach Bioorganic & Medicinal Chemistry 2003 11:1761-1768 DOI:10.1016/s0968-0896(03)00057-9 PMID:12659762
- Cannizzaro, C. E., Ashley, J. A., Janda, K. D., Houk, K. N. Experimental determination of the absolute enantioselectivity of an anti body-catalyzed Diels-Alder reaction and theoretical explorations of the origins of stereoselectivity Journal of the American Chemical Society 2003 125:2489-2506 DOI:10.1021/ja020879d PMID:12603137
- Gao, C., Mao, S. L., Ronca, F., Zhuang, S. F., Quaranta, V., Wirsching, P., Janda, K. D. De novo identification of tumor-specific internalizing human antibody-receptor pairs by phage-display methods Journal of Immunological Methods 2003 274:185-197 DOI:10.1016/s0022-1759(02)00522-7 PMID:12609544
- Lee, S. H., Clapham, B., Koch, G., Zimmermann, J., Janda, K. D. Solid-phase rhodium carbenoid n-h insertion reactions: The synthesis of a diverse array of indoles Journal of Combinatorial Chemistry 2003 5:188-196 DOI:10.1021/cc020079z PMID:12625710
- Lee, S. H., Clapham, B., Koch, G., Zimmermann, J., Janda, K. D. Rhodium carbenoid N-H insertion reactions of primary ureas: Solution and solid-phase synthesis of imidazolones Organic Letters 2003 5:511-514 DOI:10.1021/ol020244j PMID:12583756
- Wentworth, P., Wentworth, A. D., Zhu, X. Y., Wilson, I. A., Janda, K. D., Eschenmoser, A., Lerner, R. A. Evidence for the production of trioxygen species during antibody-catalyzed chemical modification of antigens Proceedings of the National Academy of Sciences of the United States of America 2003 100:1490-1493 DOI:10.1073/pnas.0437831100 PMID:12576548 PMCID:PMC149858
- Wang, Q., Raja, K. S., Janda, K. D., Lin, T. W., Finn, M. G. Blue fluorescent antibodies as reporters of steric accessibility in virus conjugates Bioconjugate Chemistry 2003 14:38-43 DOI:10.1021/bc025587g PMID:12526690
- Matsushita, M., Yoshida, K., Yamamoto, N., Wirsching, P., Lerner, R. A., Janda, K. D. High-throughput screening by using a blue-fluorescent antibody sensor Angewandte Chemie-International Edition 2003 42:5984-5987 DOI:10.1002/anie.200352793 PMID:14679549
- Ahn, J. M., Wentworth, P., Janda, K. D. Soluble polymer-supported convergent parallel library synthesis Chemical Communications 2003 480-481 DOI:10.1039/b210696e PMID:12638959
- Wentworth, P., McDunn, J. E., Wentworth, A. D., Takeuchi, C., Nieva, J., Jones, T., Bautista, C., Ruedi, J. M., Gutierrez, A., Janda, K. D., Babior, B. M., Eschenmoser, A., et al. Evidence for antibody-catalyzed ozone formation in bacterial killing and inflammation Science 2002 298:2195-2199 DOI:10.1126/science.1077642 PMID:12434011
- Gao, C., Mao, S. L., Ditzel, H. J., Farnaes, L., Wirsching, P., Lerner, R. A., Janda, K. D. A cell-penetrating peptide from a novel pVII-pIX phage-displayed random peptide library Bioorganic & Medicinal Chemistry 2002 10:4057-4065 DOI:10.1016/s0968-0896(02)00340-1 PMID:12413859
- Dickerson, T. J., Janda, K. D. A previously undescribed chemical link between smoking and metabolic disease Proceedings of the National Academy of Sciences of the United States of America 2002 99:15084-15088 DOI:10.1073/pnas.222561699 PMID:12403823 PMCID:PMC137547
- Lee, K. J., Mao, S. L., Sun, C. Z., Gao, C., Blixt, O., Arrues, S., Hom, L. G., Kaufmann, G. F., Hoffman, T. Z., Coyle, A. R., Paulson, J., Felding-Habermann, B., et al. Phage-display selection of a human single-chain fv antibody highly specific for melanoma and breast cancer cells using a chemoenzymatically synthesized G(M3)-carbohydrate antigen Journal of the American Chemical Society 2002 124:12439-12446 DOI:10.1021/ja020737j PMID:12381184
- Gao, C., Mao, S. L., Kaufmann, G., Wirsching, P., Lerner, R. A., Janda, K. D. A method for the generation of combinatorial antibody libraries using pIX phage display Proceedings of the National Academy of Sciences of the United States of America 2002 99:12612-12616 DOI:10.1073/pnas.192467999 PMID:12239343 PMCID:PMC130508
- Delgado, M., Janda, K. D. Polymeric supports for solid phase organic synthesis Current Organic Chemistry 2002 6:1031-1043 DOI:10.2174/1385272023373671
- Dickerson, T. J., Reed, N. N., Janda, K. D. Soluble polymers as scaffolds for recoverable catalysts and reagents Chemical Reviews 2002 102:3325-3343 DOI:10.1021/cr010335e PMID:12371887
- Shimomura, O., Clapham, B., Spanka, C., Mahajan, S., Janda, K. D. Application of microgels as polymer supports for organic synthesis: Preparation of a small phthalide library, a scavenger, and a borohydride reagent Journal of Combinatorial Chemistry 2002 4:436-441 DOI:10.1021/cc020012b PMID:12217015
- Sun, C. Z., Wirsching, P., Janda, K. D. Syntheses of dendritic linkers containing chlorambucil residues for the preparation of antibody-multidrug immunoconjugates Bioorganic & Medicinal Chemistry Letters 2002 12:2213-2215 DOI:10.1016/s0960-894x(02)00361-x PMID:12127540
- Reed, N. N., Delgado, M., Hereford, K., Clapham, B., Janda, K. D. Preparation of soluble and insoluble polymer supported IBX reagents Bioorganic & Medicinal Chemistry Letters 2002 12:2047-2049 DOI:10.1016/s0960-894x(02)00264-0 PMID:12113839
- Clapham, B., Lee, S. H., Koch, G., Zimmermann, J., Janda, K. D. The preparation of polymer bound beta-ketoesters and their conversion into an array of oxazoles Tetrahedron Letters 2002 43:5407-5410 DOI:10.1016/s0040-4039(02)01076-6
- Boyle, N. A., Janda, K. D. Formats for combinatorial synthesis: Solid-phase, liquid-phase and surface Current Opinion in Chemical Biology 2002 6:339-346 DOI:10.1016/s1367-5931(02)00308-3 PMID:12023115
- Delgado, M., Lee, K. J., Altobell, L., Spanka, C., Wentworth, P., Janda, K. D. A parallel approach to the discovery of carrier delivery vehicles to enhance antigen immunogenicity Journal of the American Chemical Society 2002 124:4946-4947 DOI:10.1021/ja025715b PMID:11982344
- Spanka, C., Clapham, B., Janda, K. D. Preparation of new microgel polymers and their application as supports in organic synthesis Journal of Organic Chemistry 2002 67:3045-3050 DOI:10.1021/jo016362m PMID:11975565
- Spanka, C., Wentworth, P., Janda, K. D. Developing soluble polymers for high-throughput synthetic chemistry Combinatorial Chemistry & High Throughput Screening 2002 5:233-240 PMID:11966431
- Kim, G. T., Wenz, M., Park, J. I., Hasserodt, J., Janda, K. D. Polyene substrates with unusual methylation patterns to probe the active sites of three catalytic antibodies Bioorganic & Medicinal Chemistry 2002 10:1249-1262 DOI:10.1016/s0968-0896(01)00402-3 PMID:11886788
- Zhou, B., Wirsching, P., Janda, K. D. Human antibodies against Bacillus: A model study for detection of an protection against anthrax and the bioterrorist threat Proceedings of the National Academy of Sciences of the United States of America 2002 99:5241-5246 DOI:10.1073/pnas.082121599 PMID:11959974 PMCID:PMC122754
- Isomura, S., Hoffman, T. Z., Wirsching, P., Janda, K. D. Synthesis, properties, and reactivity of cocaine benzoylthio ester possessing the cocaine absolute configuration Journal of the American Chemical Society 2002 124:3661-3668 DOI:10.1021/ja012376y PMID:11929256
- Dickerson, T. J., Janda, K. D. Aqueous aldol catalysis by a nicotine metabolite Journal of the American Chemical Society 2002 124:3220-3221 DOI:10.1021/ja017774f PMID:11916401
- Matsushita, M., Janda, K. D. Histidine kinases as targets for new antimicrobial agents Bioorganic & Medicinal Chemistry 2002 10:855-867 DOI:10.1016/s0968-0896(01)00355-8 PMID:11836091
- Isomura, S., Ashley, J. A., Wirsching, P., Janda, K. D. Antibody-catalyzed cleavage of the D-Ala-D-Lac depsipeptide: An immunological approach to the problem of vancomycin resistance Bioorganic & Medicinal Chemistry Letters 2002 12:861-864 DOI:10.1016/s0960-894x(02)00047-1 PMID:11958980
- Reger, T. S., Janda, K. D. Parallel suspension polymerization for high-throughput resin synthesis Bioorganic & Medicinal Chemistry Letters 2002 12:837-840 DOI:10.1016/s0960-894x(02)00046-x PMID:11958974
- Nicholas, K. M., Wentworth, P., Harwig, C. W., Wentworth, A. D., Shafton, A., Janda, K. D. A cofactor approach to copper-dependent catalytic antibodies Proceedings of the National Academy of Sciences of the United States of America 2002 99:2648-2653 DOI:10.1073/pnas.052001099 PMID:11880619 PMCID:PMC122402
- Delgado, M., Spanka, C., Kerwin, L. D., Wentworth, P., Janda, K. D. A tunable hydrogel for encapsulation and controlled release of bioactive proteins Biomacromolecules 2002 3:262-271 DOI:10.1021/bm010147y PMID:11888310
- Delgado, M., Spanka, C., Kerwin, L. D., Wentworth, P., Janda, K. M. Tunable hydrogel for encapsulation and controlled release of bioactive proteins Biomacromolecules 2002 3:262-271 DOI:10.1021/bm010147y PMID:11888310
- Jones, L. H., Altobell, L. J., MacDonald, M. T., Boyle, N. A., Wentworth, P., Lerner, R. A., Janda, K. D. Active immunization with a glycolipid transition state analogue protects against endotoxic shock Angewandte Chemie-International Edition 2002 41:4241-4244 DOI:10.1002/1521-3773(20021115)41:22<4241::aid-anie4241>3.0.co;2-n PMID:12434351
- Moss, J. A., Dickerson, T. J., Janda, K. D. Solid phase peptide synthesis on JandaJel(TM) resin Tetrahedron Letters 2002 43:37-40 DOI:10.1016/s0040-4039(01)02076-7
- Lee, K. J., Janda, K. D. Traceless solid-phase synthesis of 5-benzoylbenzimidazoles Canadian Journal of Chemistry-Revue Canadienne De Chimie 2001 79:1556-1561 DOI:10.1139/cjc-79-11-1556
- Kozlov, I. A., Mao, S. L., Xu, Y., Huang, X. F., Lee, L., Sears, P. S., Gao, C., Coyle, A. R., Janda, K. D., Wong, C. H. Synthesis of solid-supported mirror-image sugars: A novel method for selecting receptors for cellular-surface carbohydrates ChemBioChem 2001 2:741-746 DOI:10.1002/1439-7633(20011001)2:10<741::aid-cbic741>3.0.co;2-b PMID:11948856
- Wentworth, P., Jones, L. H., Wentworth, A. D., Zhu, X. Y., Larsen, N. A., Wilson, I. A., Xu, X., Goddard, W. A., Janda, K. D., Eschenmoser, A., Lerner, R. A. Antibody catalysis of the oxidation of water Science 2001 293:1806-1811 DOI:10.1126/science.1062722 PMID:11546867
- Brummer, O., Hoffman, T. Z., Janda, K. D. Metalloantibodies: Mercury(II)-dependent acyl transferases Bioorganic & Medicinal Chemistry 2001 9:2253-2257 DOI:10.1016/s0968-0896(01)00089-x PMID:11553463
- Cordova, A., Janda, K. D. Synthesis and catalytic antibody functionalization of dendrimers Journal of the American Chemical Society 2001 123:8248-8259 DOI:10.1021/ja001819f PMID:11516276
- Cordova, A., Tremblay, M. R., Clapham, B., Janda, K. D. A sequential application of kinetic resolution and polymer-supported scavenging for the isolation of chiral secondary alcohols Journal of Organic Chemistry 2001 66:5645-5648 DOI:10.1021/jo010529u PMID:11485501
- Larsen, N. A., Zhou, B., Heine, A., Wirsching, P., Janda, K. D., Wilson, I. A. Crystal structure of a cocaine-binding antibody Journal of Molecular Biology 2001 311:9-15 DOI:10.1006/jmbi.2001.4839 PMID:11469854
- Tremblay, M. R., Dickerson, T. J., Janda, K. D. Advances in antibody catalysis of cycloaddition reactions Advanced Synthesis & Catalysis 2001 343:577-585 DOI:10.1002/1615-4169(200108)343:6/7<577::aid-adsc577>3.0.co;2-z
- Clapham, B., Spanka, C., Janda, K. D. Solid-phase rhodium carbenoid reactions: An N-H insertion route to a diverse series of oxazoles Organic Letters 2001 3:2173-2176 DOI:10.1021/ol010075n PMID:11440572
- Dickerson, T. J., Reed, N. N., Janda, K. D. Regio-reactive resin: A platform for orthogonal loading using the polymer backbone and cross-linker Bioorganic & Medicinal Chemistry Letters 2001 11:1507-1509 DOI:10.1016/s0960-894x(01)00152-4 PMID:11412970
- Isomura, S., Wirsching, P., Janda, K. D. An immunotherapeutic program for the treatment of nicotine addiction: Hapten design and synthesis Journal of Organic Chemistry 2001 66:4115-4121 DOI:10.1021/jo001442w PMID:11397142
- Clapham, B., Reger, T. S., Janda, K. D. Polymer-supported catalysis in synthetic organic chemistry Tetrahedron 2001 57:4637-4662 DOI:10.1016/s0040-4020(01)00298-8
- Jones, L. H., Harwig, C. W., Wentworth, P., Simeonov, A., Wentworth, A. D., Py, S., Ashley, J. A., Lerner, R. A., Janda, K. D. Conversion of enediynes into quinones by antibody catalysis and in aqueous buffers: Implications for an alternative enediynes therapeutic mechanism Journal of the American Chemical Society 2001 123:3607-3608 DOI:10.1021/ja005864z PMID:11472138
- Brummer, O., La Clair, J. J., Janda, K. D. Practical screening of mercury contamination in fish tissue Bioorganic & Medicinal Chemistry 2001 9:1067-1071 DOI:10.1016/s0968-0896(01)00049-9 PMID:11354663
- Brummer, O., Clapham, B., Janda, K. D. Solid-phase synthesis of oligoesters using a JandaJel (tm) resin Tetrahedron Letters 2001 42:2257-2259 DOI:10.1016/s0040-4039(01)00172-1
- Wen, K., Han, H. S., Hoffman, T. Z., Janda, K. D., Orgel, L. E. The synthesis of beta-peptides containing guanidino groups Bioorganic & Medicinal Chemistry Letters 2001 11:689-691 DOI:10.1016/s0960-894x(01)00027-0 PMID:11266170
- Cordova, A., Janda, K. D. A highly chemo- and stereoselective synthesis of beta-keto esters via a polymer-supported lipase catalyzed transesterfication Journal of Organic Chemistry 2001 66:1906-1909 DOI:10.1021/jo001478o PMID:11262145
- Chen, D. W., Beuscher, A. E., Stevens, R. C., Wirsching, P., Lerner, R. A., Janda, K. D. Preparation of stilbene-tethered nonnatural nucleosides for use with blue-fluorescent antibodies Journal of Organic Chemistry 2001 66:1725-1732 DOI:10.1021/jo001676f PMID:11262119
- Carrera, M. R. A., Ashley, J. A., Wirsching, P., Koob, G. F., Janda, K. D. A second-generation vaccine protects against the psychoactive effects of cocaine Proceedings of the National Academy of Sciences of the United States of America 2001 98:1988-1992 DOI:10.1073/pnas.041610998 PMID:11172063
- Clapham, B., Cho, C. W., Janda, K. D. A polymer-supported proline-based diamine catalyst for the kinetic resolution of racemic secondary alcohols Journal of Organic Chemistry 2001 66:868-873 DOI:10.1021/jo0013610 PMID:11430106
- Matsushita, M., Hoffman, T. Z., Ashley, J. A., Zhou, B., Wirsching, P., Janda, K. D. Cocaine catalytic antibodies: The primary importance of linker effects Bioorganic & Medicinal Chemistry Letters 2001 11:87-90 DOI:10.1016/s0960-894x(00)00659-4 PMID:11206477
- Brummer, O., Hoffman, T. Z., Chen, D. W., Janda, K. D. Antibody-catalyzed hydrolysis of oligomeric esters: A model for the degradation of polymeric materials Chemical Communications 2001 19-20 DOI:10.1039/b008065i
- Wentworth, P., Janda, K. D. Catalytic antibodies - structure and function Cell Biochemistry and Biophysics 2001 35:63-87 DOI:10.1385/cbb:35:1:63 PMID:11898856
- Toy, P. H., Reger, T. S., Garibay, P., Garno, J. C., Malikayil, J. A., Liu, G. Y., Janda, K. D. Polytetrahydrofuran cross-linked polystyrene resins for solid-phase organic synthesis Journal of Combinatorial Chemistry 2001 3:117-124 DOI:10.1021/cc000083f PMID:11148072
- Chen, D. W., Kubiak, R. J., Ashley, J. A., Janda, K. D. Reactive immunization elicits catalytic antibodies for polyester hydrolysis Journal of the Chemical Society-Perkin Transactions 1 2001 2796-2803 DOI:10.1039/b105412k
- Lopez-Pelegrin, J. A., Wentworth, P., Sieber, F., Metz, W. A., Janda, K. D. Soluble polymer-supported chemoenzymatic synthesis of the C21-C27 fragment of the bryostatins Journal of Organic Chemistry 2000 65:8527-8531 DOI:10.1021/jo005539u PMID:11112572
- Tremblay, M. R., Wentworth, P., Lee, G. E., Janda, K. D. Parallel solid-phase synthesis and structural characterization of a library of highly substituted chiral 1,3-oxazolidines Journal of Combinatorial Chemistry 2000 2:698-709 DOI:10.1021/cc0000500 PMID:11126298
- Vaino, A. R., Janda, K. D. Solid-phase organic synthesis: A critical understanding of the resin Journal of Combinatorial Chemistry 2000 2:579-596 DOI:10.1021/cc000046o PMID:11126287
- Manzotti, R., Reger, T. S., Janda, K. D. Improved synthesis of (4-ethenylphenyl)diphenyl methanol and its application in the preparation of trityl functionalized polystyrene resin containing tetrahydrofuran derived cross-linker Tetrahedron Letters 2000 41:8417-8420 DOI:10.1016/s0040-4039(00)01529-x
- Simeonov, A., Matsushita, M., Juban, E. A., Thompson, E. H. Z., Hoffman, T. Z., Beuscher, A. E., Taylor, M. J., Wirsching, P., Rettig, W., McCusker, J. K., Stevens, R. C., Millar, D. P., et al. Blue-fluorescent antibodies Science 2000 290:307-313 DOI:10.1126/science.290.5490.307 PMID:11030644
- Manzotti, R., Tang, S. Y., Janda, K. D. Improved synthesis of prostanoids on a non-cross-linked polystyrene soluble support Tetrahedron 2000 56:7885-7892 DOI:10.1016/s0040-4020(00)00707-9
- Wentworth, A. D., Jones, L. H., Wentworth, P., Janda, K. D., Lerner, R. A. Antibodies have the intrinsic capacity to destroy antigens Proceedings of the National Academy of Sciences of the United States of America 2000 97:10930-10935 DOI:10.1073/pnas.97.20.10930 PMID:11005865
- Reed, N. N., Janda, K. D. A one-step synthesis of monoprotected polyethylene glycol ethers Journal of Organic Chemistry 2000 65:5843-5845 DOI:10.1021/jo000442t PMID:10970334
- Toy, P. H., Reger, T. S., Janda, K. D. Soluble polymer bound cleavage reagents: A multipolymer strategy for the cleavage of tertiary amines from REM resin Organic Letters 2000 2:2205-2207 DOI:10.1021/ol0059403 PMID:10930244
- Reger, T. S., Janda, K. D. Polymer-supported (Salen)Mn catalysts for asymmetric epoxidation: A comparison between soluble and insoluble matrices Journal of the American Chemical Society 2000 122:6929-6934 DOI:10.1021/ja000692r
- Vaino, A. R., Janda, K. D. Euclidean shape-encoded combinatorial chemical libraries Proceedings of the National Academy of Sciences of the United States of America 2000 97:7692-7696 DOI:10.1073/pnas.97.14.7692 PMID:10884401
- Vaino, A. R., Goodin, D. B., Janda, K. D. Investigating resins for solid phase organic synthesis: The relationship between swelling and microenvironment as probed by EPR and fluorescence spectroscopy Journal of Combinatorial Chemistry 2000 2:330-336 DOI:10.1021/cc000007c PMID:10891099
- Manzotti, R., Janda, K. D. Solid and liquid phase chemistry: Development of new supports for solid phase organic synthesis and for liquid phase chemistry Chimica Oggi-Chemistry Today 2000 18:14-18
- Lopez-Pelegrin, J. A., Janda, K. D. Solution- and soluble-polymer supported asymmetric syntheses of six-membered ring prostanoids Chemistry-a European Journal 2000 6:1917-1922 DOI:10.1002/1521-3765(20000602)6:11<1917::aid-chem1917>3.0.co;2-7 PMID:10894390
- Carrera, M. R. A., Ashley, J. A., Zhou, B., Wirsching, P., Koob, G. F., Janda, K. D. Cocaine vaccines: Antibody protection against relapse in a rat model Proceedings of the National Academy of Sciences of the United States of America 2000 97:6202-6206 DOI:10.1073/pnas.97.11.6202 PMID:10823960
- Reed, N. N., Janda, K. D. Stealth star polymers: A new high-loading scaffold for liquid-phase organic synthesis Organic Letters 2000 2:1311-1313 DOI:10.1021/ol005764y PMID:10810735
- Hasserodt, J., Janda, K. D., Lerner, R. A. A class of 4-aza-lithocholic acid-derived haptens for the generation of catalytic antibodies with steroid synthase capabilities Bioorganic & Medicinal Chemistry 2000 8:995-1003 DOI:10.1016/s0968-0896(00)00036-5 PMID:10882011
- Harwig, C. W., Hoffman, T. Z., Wentworth, A. D., Janda, K. D. A one-pot multistep approach to alpha-azido-phosphonate and phosphonothioate diesters: Key intermediates in the synthesis of haptens for the generation of antibody ligases Bioorganic & Medicinal Chemistry Letters 2000 10:915-918 DOI:10.1016/s0960-894x(00)00137-2 PMID:10853659
- Toker, J. D., Wentworth, P., Hu, Y. F., Houk, K. N., Janda, K. D. Antibody-catalysis of a bimolecular asymmetric 1,3-dipolar cycloaddition reaction Journal of the American Chemical Society 2000 122:3244-3245 DOI:10.1021/ja994423g
- Wentworth, A. D., Wentworth, P., Mansoor, U. F., Janda, K. D. A soluble polymer-supported triflating reagent: A high-throughput synthetic approach to aryl and enol triflates Organic Letters 2000 2:477-480 DOI:10.1021/ol9913237 PMID:10814355
- Hasserodt, J., Janda, K. D., Lerner, R. A. Antibodies mimic natural oxidosqualene-cyclase action in steroid ring a formation Journal of the American Chemical Society 2000 122:40-45 DOI:10.1021/ja993054l
- Sieber, F., Wentworth, P., Janda, K. D. Exploiting poly(ethylene glycol) as a matrix for liquid-phase organic synthesis Molecules 2000 5:1018-1032 DOI:10.3390/50801018
- Toy, P. H., Reger, T. S., Janda, K. D. Tailoring polystyrene solid-phase synthesis resins: Incorporation of flexible cross-linkers Aldrichimica Acta 2000 33:87-93
- Lee, K. J., Angulo, A., Ghazal, P., Janda, K. D. Soluble-polymer supported synthesis of a prostanoid library: Identification of antiviral activity Organic Letters 1999 1:1859-1862 DOI:10.1021/ol991130j PMID:10836045
- Datta, A., Wentworth, P., Shaw, J. P., Simeonov, A., Janda, K. D. Catalytically distinct antibodies prepared by the reactive immunization versus transition state analogue hapten manifolds Journal of the American Chemical Society 1999 121:10461-10467 DOI:10.1021/ja991274t
- Cordova, A., Reed, N. N., Ashley, J. A., Janda, K. D. Convenient synthesis of L-proline benzyl ester Bioorganic & Medicinal Chemistry Letters 1999 9:3119-3122 DOI:10.1016/s0960-894x(99)00546-6 PMID:10560736
- Sieber, F., Wentworth, P., Janda, K. D. Exploring the scope of poly(ethylene glycol) (PEG) as a soluble polymer matrix for the stille cross-coupling reaction Journal of Combinatorial Chemistry 1999 1:540-546 DOI:10.1021/cc990052o PMID:10748731
- Brummer, O., Wentworth, P., Weiner, D. P., Janda, K. D. Phosphorodithioates: Synthesis and evaluation of new haptens for the generation of antibody acyl transferases Tetrahedron Letters 1999 40:7307-7310 DOI:10.1016/s0040-4039(99)01501-4
- Wentworth, P., Janda, K. D. Liquid-phase chemistry: Recent advances in soluble polymer-supported catalysts, reagents and synthesis Chemical Communications 1999 1917-1924
- Garibay, P., Toy, P. H., Hoeg-Jensen, T., Janda, K. D. Application of a new solid-phase resin: Benzamide ortho-lithiation and the synthesis of a phthalide library Synlett 1999 1438-1440
- Brummer, O., Gao, C., Mao, S. L., Weiner, D. P., Janda, K. D. Design, synthesis and characterization of panning agents for the selection of metalloantibodies Letters in Peptide Science 1999 6:295-302 DOI:10.1007/bf02443425
- Toy, P. H., Janda, K. D. New supports for solid-phase organic synthesis: Development of polystyrene resins containing tetrahydrofuran derived cross-linkers Tetrahedron Letters 1999 40:6329-6332 DOI:10.1016/s0040-4039(99)01251-4
- Brummer, O., La Clair, J. J., Janda, K. D. A colorimetric ligand for mercuric ion Organic Letters 1999 1:415-418 DOI:10.1021/ol990730f
- Gao, C., Brummer, O., Mao, S. L., Janda, K. D. Selection of human metalloantibodies from a combinatorial phage single-chain antibody library Journal of the American Chemical Society 1999 121:6517-6518 DOI:10.1021/ja990966e
- Sieber, F., Wentworth, P., Toker, J. D., Wentworth, A. D., Metz, W. A., Reed, N. N., Janda, K. D. Development and application of a poly(ethylene glycol)-supported triarylphosphine reagent: Expanding the sphere of liquid-phase organic synthesis Journal of Organic Chemistry 1999 64:5188-5192 DOI:10.1021/jo9903712
- Mao, S. L., Gao, C., Lo, C. H. L., Wirsching, P., Wong, C. H., Janda, K. D. Phage-display library selection of high-affinity human single-chain antibodies to tumor-associated carbohydrate antigens sialyl Lewis(x) and Lewis(x) Proceedings of the National Academy of Sciences of the United States of America 1999 96:6953-6958 DOI:10.1073/pnas.96.12.6953 PMID:10359820
- Spivak, D. A., Hoffman, T. Z., Moore, A. H., Taylor, M. J., Janda, K. D. A comparison of flexible and constrained haptens in eliciting antibody catalysts for paraoxon hydrolysis Bioorganic & Medicinal Chemistry 1999 7:1145-1150 DOI:10.1016/s0968-0896(99)00026-7 PMID:10428386
- Gao, C., Mao, S. L., Lo, C. H. L., Wirsching, P., Lerner, R. A., Janda, K. D. Making artificial antibodies: A format for phage display of combinatorial heterodimeric arrays Proceedings of the National Academy of Sciences of the United States of America 1999 96:6025-6030 DOI:10.1073/pnas.96.11.6025 PMID:10339535
- Taylor, M. J., Yli-Kauhaluoma, J. T., Ashley, J. A., Wirsching, P., Lerner, R. A., Janda, K. D. The alpha-ketoamide group: A new motif for the elicitation of catalytic antibodies for acyl-transfer reactions Journal of the Chemical Society-Perkin Transactions 1 1999 1133-1134 DOI:10.1039/a902475a
- Han, H. S., Cho, C. W., Janda, K. D. A substrate-based methodology that allows the regioselective control of the catalytic aminohydroxylation reaction Chemistry-a European Journal 1999 5:1565-1569 DOI:10.1002/(sici)1521-3765(19990503)5:5<1565::aid-chem1565>3.0.co;2-j
- Berg, T., Simeonov, A., Janda, K. D. A combined parallel synthesis and screening of macrocyclic lanthanide complexes for the cleavage of phospho di- and triesters and double-stranded DNA Journal of Combinatorial Chemistry 1999 1:96-100 DOI:10.1021/cc9800125 PMID:10746017
- Janda, K. D., Wentworth, A. D. A merging of chemistry and biology in terms of antibody catalysis Phosphorus Sulfur and Silicon and the Related Elements 1999 146:117-120
- Wentworth, P., Janda, K. D. Antibody catalysis of phosphodiester hydrolysis: A survey of hapten strategies Phosphorus Sulfur and Silicon and the Related Elements 1999 146:247-250
- Han, H., Yoon, J., Janda, K. D. Azatides as peptidomimetics: solution and liquid phase syntheses Methods in Molecular Medicine 1999 23:87-102 DOI:10.1385/0-89603-517-4:87 PMID:21380893
- Paschall, C. M., Hasserodt, J., Jones, T., Lerner, R. A., Janda, K. D., Christianson, D. W. Convergence of catalytic antibody and terpene cyclase mechanisms: Polyene cyclization directed by carbocation - pi-interactions Angewandte Chemie-International Edition 1999 38:1743-1747 DOI:10.1002/(sici)1521-3773(19990614)38:12<1743::aid-anie1743>3.0.co;2-3
- Ashley, J. A., Wirsching, P., Janda, K. D., Lin, C. H. Monitoring chemical warfare agents: A new method for the detection of methylphosphonic acid Angewandte Chemie-International Edition 1999 38:1793-1795 DOI:10.1002/(sici)1521-3773(19990614)38:12<1793::aid-anie1793>3.3.co;2-l
- Yoon, J. Y., Cho, C. W., Han, H., Janda, K. D. Solution and soluble polymer synthesis of 3-aminoimidazoline-2,4-diones Chemical Communications 1998 2703-2704 DOI:10.1039/a807067i
- Taylor, M. J., Hoffman, T. Z., Yli-Kauhaluoma, J. T., Lerner, R. A., Janda, K. D. A light-activated antibody catalyst Journal of the American Chemical Society 1998 120:12783-12790 DOI:10.1021/ja982711r
- Zhao, X. Y., Metz, W. A., Sieber, F., Janda, K. D. Expanding on the purification methodology of polyethylene glycol (PEG) bound molecules: The synthesis of 3,5-pyrazolidinediones Tetrahedron Letters 1998 39:8433-8436 DOI:10.1016/s0040-4039(98)01921-2
- Gravert, D. J., Datta, A., Wentworth, P., Janda, K. D. Soluble supports tailored for organic synthesis: Parallel polymer synthesis via sequential normal/living free radical processes Journal of the American Chemical Society 1998 120:9481-9495 DOI:10.1021/ja980241v
- Zhao, X., Janda, K. D. Soluble polymer traceless linker investigations: Solvent effects on the desulfonylation of polyethylene glycol (PEG) substituted aryl alkyl sulfones with sodium amalgam Bioorganic & Medicinal Chemistry Letters 1998 8:2439-2442 DOI:10.1016/s0960-894x(98)00441-7 PMID:9873557
- Hori, M., Gravert, D. J., Wentworth, P., Janda, K. D. Investigating highly crosslinked macroporous resins for solid-phase synthesis Bioorganic & Medicinal Chemistry Letters 1998 8:2363-2368 DOI:10.1016/s0960-894x(98)00427-2 PMID:9873542
- Chen, S. Q., Janda, K. D. Total synthesis of naturally occurring prostaglandin F2 alpha on a non-cross-linked polystyrene support Tetrahedron Letters 1998 39:3943-3946 DOI:10.1016/s0040-4039(98)00729-1
- Wentworth, P., Liu, Y. Q., Wentworth, A. D., Fan, P., Foley, M. J., Janda, K. D. A bait and switch hapten strategy generates catalytic antibodies for phosphodiester hydrolysis Proceedings of the National Academy of Sciences of the United States of America 1998 95:5971-5975 DOI:10.1073/pnas.95.11.5971 PMID:9600901
- Berg, T., Vandersteen, A. M., Janda, K. D. High-throughput synthesis and direct screening for the discovery of novel hydrolytic metal complexes Bioorganic & Medicinal Chemistry Letters 1998 8:1221-1224 DOI:10.1016/s0960-894x(98)00199-1 PMID:9871739
- Yli-Kauhaluoma, J. T., Harwig, C. W., Wentworth, P., Janda, K. D. Unexpected 1,3-oxazolidine formation in the attempted oxidation of N-aryl-N-methyl substituted beta-amino alcohols using pyridinium dichromate Tetrahedron Letters 1998 39:2269-2272 DOI:10.1016/s0040-4039(98)00289-5
- Heine, A., Stura, E. A., Yli-Kauhaluoma, J. T., Gao, C., Deng, Q. L., Beno, B. R., Houk, K. N., Janda, K. D., Wilson, I. A. An antibody exo Diels-Alderase inhibitor complex at 1.95 Å resolution Science 1998 279:1934-1940 DOI:10.1126/science.279.5358.1934 PMID:9506943
- Han, H. S., Yoon, J., Janda, K. D. An efficient asymmetric route to 2,3-diaminobutanoic acids Journal of Organic Chemistry 1998 63:2045-2048 DOI:10.1021/jo9720391
- Gravert, D. J., Janda, K. D. Bifunctional initiators for free radical polymerization of non-crosslinked block copolymers Tetrahedron Letters 1998 39:1513-1516 DOI:10.1016/s0040-4039(98)00070-7
- Gao, C., Lavey, B. J., Lo, C. H. L., Datta, A., Wentworth, P., Janda, K. D. Direct selection for catalysis from combinatorial antibody libraries using a boronic acid probe: Primary amide bond hydrolysis Journal of the American Chemical Society 1998 120:2211-2217 DOI:10.1021/ja9720220
- Wentworth, P., Janda, K. D. Catalytic antibodies Current Opinion in Chemical Biology 1998 2:138-144 DOI:10.1016/s1367-5931(98)80046-x PMID:9667908
- Wentworth, P., Janda, K. D. Generating and analyzing combinatorial chemistry libraries Current Opinion in Biotechnology 1998 9:109-115 DOI:10.1016/s0958-1669(98)80093-1
- Han, H., Yoon, J., Janda, K. D. Investigations of azapeptides as mimetics of Leu-enkephalin Bioorganic & Medicinal Chemistry Letters 1998 8:117-120 DOI:10.1016/s0960-894x(97)10198-6 PMID:9871637
- Hoffman, T. Z., Xie, Y. L., Wirsching, P., Janda, K. D., Lin, C. H. An antibody transesterase derived from reactive immunization that utilizes a wide variety of alcohol substrates Chemical Communications 1998 1075-1076 DOI:10.1039/a801569d
- Lerner, R. A., Barbas, C. F., Janda, K. D. Making enzymes Harvey Lectures 1998 92:1-40 PMID:15372741
- Gao, C., Lo, C. H. L., Mao, S., Wirsching, P., Lerner, R. A., Janda, K. D., Lin, C. H. Making chemistry selectable by linking it to infectivity Proceedings of the National Academy of Sciences of the United States of America 1997 94:11777-11782 DOI:10.1073/pnas.94.22.11777 PMID:9342313
- Lo, C. H. L., Wentworth, P., Jung, K. W., Yoon, J., Ashley, J. A., Janda, K. D. Reactive immunization strategy generates antibodies with high catalytic proficiencies Journal of the American Chemical Society 1997 119:10251-10252 DOI:10.1021/ja971442m
- Chen, S. Q., Janda, K. D. Synthesis of prostaglandin E-2 methyl ester on a soluble-polymer support for the construction of prostanoid libraries Journal of the American Chemical Society 1997 119:8724-8725 DOI:10.1021/ja971634h
- Hasserodt, J., Janda, K. D. Syntheses of octahydroquinoline-N-oxides: Haptens designed to elicit catalytic antibodies that control a terpenoid-like cascade cyclisation Tetrahedron 1997 53:11237-11256 DOI:10.1016/s0040-4020(97)00715-1
- Zhao, X. Y., Janda, K. D. Syntheses of alkylated malonates on a traceless linker derived soluble polymer support Tetrahedron Letters 1997 38:5437-5440 DOI:10.1016/s0040-4039(97)01216-1
- Hasserodt, J., Janda, K. D., Lerner, R. A. Formation of bridge-methylated decalins by antibody-catalyzed tandem cationic cyclization Journal of the American Chemical Society 1997 119:5993-5998 DOI:10.1021/ja970675a
- Gravert, D. J., Janda, K. D. Synthesis on soluble polymers: New reactions and the construction of small molecules Current Opinion in Chemical Biology 1997 1:107-113 DOI:10.1016/s1367-5931(97)80116-0 PMID:9667833
- Jung, K. W., Zhao, X. Y., Janda, K. D. Development of new linkers for the formation of aliphatic C-H bonds on polymeric supports Tetrahedron 1997 53:6645-6652 DOI:10.1016/s0040-4020(97)00222-6
- Wentworth, P., Janda, K. D. Synthesis of oxorhenium(V) and oxotechnetium(V) complexes as inhibitors of ribonucleases and for the generation of catalytic antibodies Synlett 1997 537-543
- Weiner, D. P., Wiemann, T., Wolfe, M. M., Wentworth, P., Janda, K. D. A pentacoordinate oxorhenium(V) metallochelate elicits antibody catalysts for phosphodiester cleavage Journal of the American Chemical Society 1997 119:4088-4089 DOI:10.1021/ja970107v
- Wentworth, P., Vandersteen, A. M., Janda, K. D. Poly(ethylene glycol) (PEG) as a reagent support: The preparation and utility of a PEG-triarylphosphine conjugate in liquid-phase organic synthesis (LPOS) Chemical Communications 1997 759-760
- Han, H. S., Janda, K. D. A soluble polymer-bound approach to the sharpless catalytic asymmetric dihydroxylation (AD) reaction: Preparation and application of a (DHQD)(2)PHAL-PEG-OMe ligand Tetrahedron Letters 1997 38:1527-1530 DOI:10.1016/s0040-4039(97)00129-9
- Li, T. Y., Lerner, R. A., Janda, K. D. Antibody-catalyzed cationic reactions: Rerouting of chemical transformations via antibody catalysis Accounts of Chemical Research 1997 30:115-121 DOI:10.1021/ar960172u
- Gravert, D. J., Janda, K. D. Organic synthesis on soluble polymer supports: Liquid-phase methodologies Chemical Reviews 1997 97:489-509 DOI:10.1021/cr960064l PMID:11848880
- Janda, K. D., Lo, L. C., Lo, C. H. L., Sim, M. M., Wang, R., Wong, C. H., Lerner, R. A. Chemical selection for catalysis in combinatorial antibody libraries Science 1997 275:945-948 DOI:10.1126/science.275.5302.945 PMID:9020070
- Zhao, X. Y., Jung, K. W., Janda, K. D. Soluble polymer synthesis: An improved traceless linker methodology for aliphatic C-H bond formation Tetrahedron Letters 1997 38:977-980 DOI:10.1016/s0040-4039(96)02503-8
- Han, H., Janda, K. D. Multipolymer-supported substrate and ligand approach to the sharpless asymmetric dihydroxylation Angewandte Chemie-International Edition 1997 36:1731-1733 DOI:10.1002/anie.199717311
- Hoffman, T. Z., Wirsching, P., Barbas, C. F., Janda, K. D., Lerner, R. A., Lin, C. H. On roads not taken in the evolution of protein catalysts: Antibody steroid isomerases that use an enamine mechanism Proceedings of the National Academy of Sciences of the United States of America 1997 94:11773-11776 DOI:10.1073/pnas.94.22.11773 PMID:9342312
- Wentworth, P., Wiemann, T., Janda, K. D. A new class of pentacoordinate ribonuclease inhibitors: Synthesis, characterization, and inhibition studies of ribonucleoside and anhydropentofuranose oxorhenium(V) complexes Journal of the American Chemical Society 1996 118:12521-12527 DOI:10.1021/ja9611248
- Hasserodt, J., Janda, K. D., Lerner, R. A. Antibody catalyzed terpenoid cyclization Journal of the American Chemical Society 1996 118:11654-11655 DOI:10.1021/ja954316w
- Lavey, B. J., Janda, K. D. Catalytic antibody mediated hydrolysis of paraoxon Journal of Organic Chemistry 1996 61:7633-7636 DOI:10.1021/jo960629d PMID:11667704
- Jung, K. W., Janda, K. D., Sanfilippo, P. J., Wachter, M. Syntheses and biological evaluation of two new naproxen analogs Bioorganic & Medicinal Chemistry Letters 1996 6:2281-2282
- Vandersteen, A. M., Han, H., Janda, K. D. Liquid-phase combinatorial synthesis: In search of small-molecule enzyme mimics Molecular Diversity 1996 2:89-96 DOI:10.1007/bf01718705 PMID:9238638
- Vandersteen, A. M., Janda, K. D. A re-examination of two linear pentapeptides claimed to be serine protease mimics Journal of the American Chemical Society 1996 118:8787-8790 DOI:10.1021/ja9616140
- Wentworth, P., Janda, K. D. A facile and efficient route to 3',5'-diamino-3',5'-dideoxynucleosides Chemical Communications 1996 2097-2098 DOI:10.1039/cc9960002097
- Lo, L. C., Lo, C. H. L., Janda, K. D., Kassel, D. B., Raushel, F. M. A versatile mechanism based reaction probe for the direct selection of biocatalysts Bioorganic & Medicinal Chemistry Letters 1996 6:2117-2120 DOI:10.1016/0960-894x(96)00379-4
- Jung, K. W., Zhao, X. Y., Janda, K. D. A linker that allows efficient formation of aliphatic C-H bonds on polymeric supports Tetrahedron Letters 1996 37:6491-6494 DOI:10.1016/0040-4039(96)01419-0
- Han, H. S., Janda, K. D. Soluble polymer-bound ligand-accelerated catalysis: Asymmetric dihydroxylation Journal of the American Chemical Society 1996 118:7632-7633 DOI:10.1021/ja9608095
- Sakurai, M., Wirsching, P., Janda, K. D. Design and synthesis of a cocaine-diamide hapten for vaccine development Tetrahedron Letters 1996 37:5479-5482 DOI:10.1016/0040-4039(96)01170-7
- Lavey, B. J., Janda, K. D. Antibody catalyzed hydrolysis of a phosphotriester Bioorganic & Medicinal Chemistry Letters 1996 6:1523-1524 DOI:10.1016/s0960-894x(96)00266-1
- Sakurai, M., Wirsching, P., Janda, K. D. Synthesis of a nucleoside hapten with a P(O)-O-N linkage to elicit catalytic antibodies with phosphodiesterase activity Bioorganic & Medicinal Chemistry Letters 1996 6:1055-1060 DOI:10.1016/0960-894x(96)00169-2
- Han, H., Janda, K. D. Azatides: Solution and liquid phase syntheses of a new peptidomimetic Journal of the American Chemical Society 1996 118:2539-2544 DOI:10.1021/ja9535470
- Li, T. G., Janda, K. D., Lerner, R. A. Cationic cyclopropanation by antibody catalysis Nature 1996 379:326-327 PMID:8552185
- Yli-Kauhaluoma, J. T., Ashley, J. A., Lo, C. H. L., Coakley, J., Wirsching, P., Janda, K. D. Catalytic antibodies with peptidyl-prolyl cis-trans isomerase activity Journal of the American Chemical Society 1996 118:5496-5497 DOI:10.1021/ja954206p
- Lo, C. H. L., Gao, C., Mao, S. L., Matsui, K., Lerner, R. A., Janda, K. D. Chain shuffling: Investigations into the specificity and selectivity of antibody catalysis Israel Journal of Chemistry 1996 36:195-198
- Janda, K. D., Han, H. S. Combinatorial chemistry: A liquid-phase approach Combinatorial Chemistry 1996 267:234-247 PMID:8743320
- Wirsching, P., Ashley, J. A., Lo, C. H. L., Janda, K. D., Lerner, R. A. Reactive immunization Science 1995 270:1775-1782 DOI:10.1126/science.270.5243.1775 PMID:8525366
- Carrera, M. R. A., Ashley, J. A., Parsons, L. H., Wirsching, P., Koob, G. F., Janda, K. D. Suppression of psychoactive effects of cocaine by active immunization Nature 1995 378:727-730 DOI:10.1038/378727a0 PMID:7501020
- Li, T. Y., Janda, K. D. Synthesis of a bifunctional hapten designed to mimic both transition-state and to induce bait and switch catalysis Bioorganic & Medicinal Chemistry Letters 1995 5:2001-2004 DOI:10.1016/0960-894x(95)00341-p
- Han, H. S., Wolfe, M. M., Brenner, S., Janda, K. D. Liquid-phase combinatorial synthesis Proceedings of the National Academy of Sciences of the United States of America 1995 92:6419-6423 DOI:10.1073/pnas.92.14.6419 PMID:7541541 PMCID:PMC41529
- Li, T. Y., Hilton, S., Janda, K. D. Remarkable ability of different antibody catalysts to control and diversify the product outcome of cationic cyclization reactions Journal of the American Chemical Society 1995 117:3308-3309 DOI:10.1021/ja00116a050
- Fenniri, H., Janda, K. D., Lerner, R. A. Encoded reaction cassette for the highly sensitive detection of the making and breaking of chemical-bonds Proceedings of the National Academy of Sciences of the United States of America 1995 92:2278-2282 DOI:10.1073/pnas.92.6.2278 PMID:7892261
- Janda, K. D., Shevlin, C. G., Lerner, R. A. Oxepane synthesis along a disfavored pathway - the rerouting of a chemical-reaction using a catalytic antibody Journal of the American Chemical Society 1995 117:2659-2660 DOI:10.1021/ja00114a035
- Li, T. Y., Janda, K. D., Hilton, S., Lerner, R. A. An antibody-catalyzed nucleophilic-substitution reaction at a primary carbon that appears to proceed by an ionization mechanism Journal of the American Chemical Society 1995 117:2367-2368 DOI:10.1021/ja00113a033
- Li, T. Y., Hilton, S., Janda, K. D. The potential application of catalytic antibodies to protecting group removal - catalytic antibodies with broad substrate tolerance Journal of the American Chemical Society 1995 117:2123-2127 DOI:10.1021/ja00113a001
- Yli-Kauhaluoma, J. T., Ashley, J. A., Lo, C. H., Tucker, L., Wolfe, M. M., Janda, K. D. Anti-metallocene antibodies: A new approach to enantioselective catalysis of the Diels-Alder reaction Journal of the American Chemical Society 1995 117:7041-7047 DOI:10.1021/ja00132a001
- Rosenblum, J. S., Lo, L. C., Li, T. Y., Janda, K. D., Lerner, R. A. Antibody-catalyzed phosphate triester hydrolysis Angewandte Chemie-International Edition 1995 34:2275-2277 DOI:10.1002/anie.199522751
- Erb, E., Janda, K. D., Brenner, S. Recursive deconvolution of combinatorial chemical libraries Proceedings of the National Academy of Sciences of the United States of America 1994 91:11422-11426 DOI:10.1073/pnas.91.24.11422 PMID:7972077 PMCID:PMC45243
- Janda, K. D. Tagged versus untagged libraries - methods for the generation and screening of combinatorial chemical libraries Proceedings of the National Academy of Sciences of the United States of America 1994 91:10779-10785 DOI:10.1073/pnas.91.23.10779 PMID:7971962
- Cravatt, B. F., Ashley, J. A., Janda, K. D., Boger, D. L., Lerner, R. A. Crossing extreme mechanistic barriers by antibody catalysis: Syn elimination to a cis olefin Journal of the American Chemical Society 1994 116:6013-6014 DOI:10.1021/ja00092a080
- Li, T. Y., Janda, K. D., Ashley, J. A., Lerner, R. A. Antibody-catalyzed cationic cyclization Science 1994 264:1289-1293 DOI:10.1126/science.8191282 PMID:8191282
- Janda, K. D. Catalytic antibodies and enzyme-inhibitors Pure and Applied Chemistry 1994 66:703-708 DOI:10.1351/pac199466040703
- Janda, K. D.*, Lo, C. H. L.*, Li, T. Y., Barbas, C. F., Wirsching, P., Lerner, R. A. Direct selection for a catalytic mechanism from combinatorial antibody libraries Proceedings of the National Academy of Sciences of the United States of America 1994 91:2532-2536 DOI:10.1073/pnas.91.7.2532 PMID:8146149 (* = equal contribution)
- Shevlin, C. G., Hilton, S., Janda, K. D. Automation of antibody catalysis - a practical methodology for the use of catalytic antibodies in organic-synthesis Bioorganic & Medicinal Chemistry Letters 1994 4:297-302 DOI:10.1016/s0960-894x(01)80132-3
- Yli-Kauhaluoma, J. T., Janda, K. D. An expedient synthesis of isopropyl anisoles and veratroles Tetrahedron Letters 1994 35:4509-4510 DOI:10.1016/s0040-4039(00)60713-x
- Janda, K. D. Catalytic antibodies - the rerouting of chemical-reactions Biochemical Society Transactions 1993 21:1090-1095 PMID:8131905
- Nielsen, J., Brenner, S., Janda, K. D. Synthetic methods for the implementation of encoded combinatorial chemistry Journal of the American Chemical Society 1993 115:9812-9813 DOI:10.1021/ja00074a063
- Gouverneur, V. E., Houk, K. N., Depascualteresa, B., Beno, B., Janda, K. D., Lerner, R. A. Control of the exo-pathway and endo-pathway of the Diels-Alder reaction by antibody catalysis Science 1993 262:204-208 DOI:10.1126/science.8211138 PMID:8211138
- Na, J., Houk, K. N., Shevlin, C. G., Janda, K. D., Lerner, R. A. The energetic advantage of 5-exo versus 6-endo epoxide openings - a preference overwhelmed by antibody catalysis Journal of the American Chemical Society 1993 115:8453-8454 DOI:10.1021/ja00071a067
- Wade, W. S., Ashley, J. A., Jahangiri, G. K., McElhaney, G., Janda, K. D., Lerner, R. A. A highly specific metal-activated catalytic antibody Journal of the American Chemical Society 1993 115:4906-4907 DOI:10.1021/ja00064a068
- Ikeda, S., Janda, K. D. Recent development on the research of catalytic antibodies and their applications Journal of Synthetic Organic Chemistry Japan 1993 51:284-297
- Ashley, J. A., Lo, C. H. L., McElhaney, G. P., Wirsching, P., Janda, K. D. A catalytic antibody model for plp-dependent decarboxylases Journal of the American Chemical Society 1993 115:2515-2516 DOI:10.1021/ja00059a061
- Janda, K. D., Shevlin, C. G., Lerner, R. A. Antibody catalysis of a disfavored chemical transformation Science 1993 259:490-493 DOI:10.1126/science.8424171
- Chen, Y. C. J., Danon, T., Sastry, L., Mubaraki, M., Janda, K. D., Lerner, R. A. Catalytic antibodies from combinatorial libraries Journal of the American Chemical Society 1993 115:357-358 DOI:10.1021/ja00054a058
- Weinhouse, M. I., Janda, K. D. A new methodology for the preparation of vinyl esters Synthesis-Stuttgart 1993 81-83
- Ashley, J. A., Janda, K. D. Antibody catalysis in low water content media Journal of Organic Chemistry 1992 57:6691-6693 DOI:10.1021/jo00051a003
- Ikeda, S., Ashley, J. A., Wirsching, P., Janda, K. D. Psi PO2-CH2N+ , a new amide bond replacement - potent, slow-binding inhibition of the HIV protease Journal of the American Chemical Society 1992 114:7604-7606 DOI:10.1021/ja00045a067
- Fernholz, E., Schloeder, D., Liu, K. K. C., Bradshaw, C. W., Huang, H. M., Janda, K., Lerner, R. A., Wong, C. H. Specificity of antibody-catalyzed transesterifications using enol esters - a comparison with lipase reactions Journal of Organic Chemistry 1992 57:4756-4761 DOI:10.1021/jo00043a042
- Gibbs, R. A., Benkovic, P. A., Janda, K. D., Lerner, R. A., Benkovic, S. J. Substituent effects on an antibody-catalyzed hydrolysis of phenyl-esters - further evidence for an acyl-antibody intermediate Journal of the American Chemical Society 1992 114:3528-3534 DOI:10.1021/ja00035a057
- Reymond, J. L., Janda, K. D., Lerner, R. A. Highly enantioselective protonation catalyzed by an antibody Journal of the American Chemical Society 1992 114:2257-2258 DOI:10.1021/ja00032a050
- Chen, Y. C. J., Janda, K. D. A new approach toward the inhibition of ribonucleases - a water-stable ribonucleoside technetium chelate Journal of the American Chemical Society 1992 114:1488-1489 DOI:10.1021/ja00030a058
- Fujii, I., Lerner, R. A., Janda, K. D. Enantiofacial protonation by catalytic antibodies Journal of the American Chemical Society 1991 113:8528-8529 DOI:10.1021/ja00022a054
- Ikeda, S., Weinhouse, M. I., Janda, K. D., Lerner, R. A., Danishefsky, S. J. Asymmetric induction via a catalytic antibody Journal of the American Chemical Society 1991 113:7763-7764 DOI:10.1021/ja00020a049
- Hein, M. B., Tang, Y., McLeod, D. A., Janda, K. D., Hiatt, A. Evaluation of immunoglobulins from plant-cells Biotechnology Progress 1991 7:455-461 DOI:10.1021/bp00011a011 PMID:1367994
- Janda, K. D., Weinhouse, M. I., Danon, T., Pacelli, K. A., Schloeder, D. M. Antibody bait and switch catalysis - a survey of antigens capable of inducing abzymes with acyl-transfer properties Journal of the American Chemical Society 1991 113:5427-5434 DOI:10.1021/ja00014a039
- Chen, Y. C. J., Hansske, F., Janda, K. D., Robins, M. J. Nucleic-acid related-compounds .64. Synthesis of 2',3'-diazido-2',3'-dideoxyadenosine and 2',3'-diamino-2',3'-dideoxyadenosine from 9-(Beta-D-Arabinofuranosyl)adenine Journal of Organic Chemistry 1991 56:3410-3413 DOI:10.1021/jo00010a042
- Wirsching, P., Ashley, J. A., Benkovic, S. J., Janda, K. D., Lerner, R. A. An unexpectedly efficient catalytic antibody operating by ping-pong and induced fit mechanisms Science 1991 252:680-685 DOI:10.1126/science.2024120 PMID:2024120
- Kang, A. S., Barbas, C. F., Janda, K. D., Benkovic, S. J., Lerner, R. A. Linkage of recognition and replication functions by assembling combinatorial antibody Fab libraries along phage surfaces Proceedings of the National Academy of Sciences of the United States of America 1991 88:4363-4366 DOI:10.1073/pnas.88.10.4363 PMID:1903540
- Janda, K. D., Benkovic, S. J., McLeod, D. A., Schloeder, D. M., Lerner, R. A. Substrate attenuation - an approach to improve antibody catalysis Tetrahedron 1991 47:2503-2506 DOI:10.1016/s0040-4020(01)81784-1
- Janda, K. D., Ashley, J. A., Jones, T. M., McLeod, D. A., Schloeder, D. M., Weinhouse, M. I., Lerner, R. A., Gibbs, R. A., Benkovic, P. A., Hilhorst, R., Benkovic, S. J. Catalytic antibodies with acyl-transfer capabilities - mechanistic and kinetic investigations Journal of the American Chemical Society 1991 113:291-297 DOI:10.1021/ja00001a042
- Benkovic, S. J., Adams, J., Janda, K. D., Lerner, R. A. A catalytic antibody uses a multistep kinetic sequence Ciba Foundation Symposia 1991 159:4-12 PMID:1959451
- Reymond, J. L., Janda, K. D., Lerner, R. A. Antibody catalysis of glycosidic bond hydrolysis Angewandte Chemie-International Edition 1991 30:1711-1713 DOI:10.1002/anie.199117111
- McLeod, D. A., Brinkworth, R. I., Ashley, J. A., Janda, K. D., Wirsching, P. Phosphonamidates and phosphonamidate esters as HIV-1 protease inhibitors Bioorganic & Medicinal Chemistry Letters 1991 1:653-658 DOI:10.1016/s0960-894x(01)81171-9
- Sastry, L., Mubaraki, M., Janda, K. D., Benkovic, S. J., Lerner, R. A. Screening combinatorial antibody libraries for catalytic acyl transfer-reactions Ciba Foundation Symposia 1991 159:145-155 PMID:1835693
- Benkovic, S. J., Adams, J. A., Borders, C. L., Janda, K. D., Lerner, R. A. The enzymatic nature of antibody catalysis - development of multistep kinetic processing Science 1990 250:1135-1139 DOI:10.1126/science.2251500 PMID:2251500
- Janda, K. D., Ashley, J. A., Jones, T. M., McLeod, D. A., Schloeder, D. M., Weinhouse, M. I. Immobilized catalytic antibodies in aqueous and organic-solvents Journal of the American Chemical Society 1990 112:8886-8888 DOI:10.1021/ja00180a035
- Janda, K. D. New strategies for the design of catalytic antibodies Biotechnology Progress 1990 6:178-181 DOI:10.1021/bp00003a002 PMID:1366610
- Janda, K. D., Weinhouse, M. I., Schloeder, D. M., Lerner, R. A., Benkovic, S. J. Bait and switch strategy for obtaining catalytic antibodies with acyl-transfer capabilities Journal of the American Chemical Society 1990 112:1274-1275 DOI:10.1021/ja00159a074
- Janda, K. D., Ashley, J. A. Syntheses of the saturated analogs of 4-nitrophenol and 4-nitroaniline Synthetic Communications 1990 20:1073-1082 DOI:10.1080/00397919008052811
- Sastry, L., Altingmees, M., Huse, W. D., Short, J. M., Sorge, J. A., Hay, B. N., Janda, K. D., Benkovic, S. J., Lerner, R. A. Cloning of the immunological repertoire in escherichia-coli for generation of monoclonal catalytic antibodies - construction of a heavy-chain variable region-specific cDNA library Proceedings of the National Academy of Sciences of the United States of America 1989 86:5728-5732 DOI:10.1073/pnas.86.15.5728 PMID:2503822
- Janda, K. D., Benkovic, S. J., Lerner, R. A. Catalytic antibodies with lipase activity and R-substrate or S-substrate selectivity Science 1989 244:437-440 DOI:10.1126/science.2717936 PMID:2717936
- Janda, K. D., Schloeder, D., Benkovic, S. J., Lerner, R. A. Induction of an antibody that catalyzes the hydrolysis of an amide bond Science 1988 241:1188-1191 DOI:10.1126/science.3413482 PMID:3413482
- Janda, K. D., Lerner, R. A., Tramontano, A. Antibody catalysis of bimolecular amide formation Journal of the American Chemical Society 1988 110:4835-4837 DOI:10.1021/ja00222a056
- Tramontano, A., Kang, A. S., Janda, K., Napper, A. D., Benkovic, S. J., Lerner, R. A. Catalytic antibodies Cold Spring Harbor Symposia on Quantitative Biology 1987 52:91-96 PMID:3454298
- Tramontano, A., Janda, K. D., Lerner, R. A. Catalytic antibodies Science 1986 234:1566-1570 DOI:10.1126/science.3787261 PMID:3787261
- Tramontano, A., Janda, K. D., Lerner, R. A. Chemical-reactivity at an antibody-binding site elicited by mechanistic design of a synthetic antigen Proceedings of the National Academy of Sciences of the United States of America 1986 83:6736-6740 DOI:10.1073/pnas.83.18.6736 PMID:3462723
- Bates, R. B., Janda, K. D., Wright, M. E. N-Isobutyrylbenzamide, C11H13NO2 Acta Crystallographica Section C-Crystal Structure Communications 1985 41:263-264 DOI:10.1107/s0108270185003559
- Bates, R. B., Janda, K. D. A convenient synthesis of alpha-acylamino alcohols from azlactones Synthesis-Stuttgart 1984 310-311
- Bates, R. B., Fletcher, F. A., Janda, K. D., Miller, W. A. A convenient synthesis of unsymmetrical acyclic imides Journal of Organic Chemistry 1984 49:3038-3038 DOI:10.1021/jo00190a039
- Bates, R. B., Gin, S. L., Hassen, M. A., Hruby, V. J., Janda, K. D., Kriek, G. R., Michaud, J. P., Vine, D. B. Synthesis of cyclo-N-methyl-L-tyr-N-methyl-L-tyr-D-ala-L-ala-O,N-dimethyl-L-tyr-L-ala, a cyclic hexapeptide related to the antitumor agent deoxybouvardin Heterocycles 1984 22:785-790 DOI:10.3987/R-1984-04-0785
- Janda, K. D., McConnell, W. W., Nelson, G. O., Wright, M. E. Preparation and reactivity of the new cyclopentadienyl-bridged complex (Me2SICH2CH2SIME2)(C5H4Fe(CO)2)2 Journal of Organometallic Chemistry 1983 259:139-143 DOI:10.1016/0022-328x(83)87157-5
- Bates, R. B., Janda, K. D. High-yield benzyne synthesis of diaryl ethers Journal of Organic Chemistry 1982 47:4374-4376 DOI:10.1021/jo00143a051
