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Jacob, Nicholas Taylor
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Jacob, Nicholas Taylor

Graduate Student
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Positions

  • 2018 - Professional Scientific Collaborator, Scripps Research
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Publications

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  • academic article

    • degree-related publication Jacob, N. T., Miranda, P. O., Shirey, R. J., Gautam, R., Zhou, B., Izquierdo, M. E. D., Hixon, M. S., Hart, J. R., Ueno, L., Vogt, P. K., Janda, K. D. Synthetic molecules for disruption of the MYC protein-protein interface Bioorganic & Medicinal Chemistry  2018 26:4234-4239  DOI:10.1016/j.bmc.2018.07.019  PMID:30037753
    • degree-related publication Miranda, P. O., Cubitt, B., Jacob, N. T., Janda, K. D., de la Torre, J. C. Mining a Kröhnke pyridine library for anti-arenavirus activity ACS Infectious Diseases  2018 4:815-824  DOI:10.1021/acsinfecdis.7b00236  PMID:29405696
    • degree-related publication Jacob, N. T., Anraku, K., Kimishima, A., Zhou, B., Collins, K. C., Lockner, J. W., Ellis, B. A., Janda, K. D. A bioconjugate leveraging xenoreactive antibodies to alleviate cocaine-induced behavior Chemical Communications  2017 53:8156-8159  DOI:10.1039/c7cc04055e  PMID:28677711
    • degree-related publication Anraku, K., Sato, S., Jacob, N. T., Eubanks, L. M., Ellis, B. A., Janda, K. D. The design and synthesis of an α-Gal trisaccharide epitope that provides a highly specific anti-Gal immune response Organic & Biomolecular Chemistry  2017 15:2979-2992  DOI:10.1039/c7ob00448f  PMID:28294277
    • degree-related publication Zhou, B., Eubanks, L. M., Jacob, N. T., Ellis, B., Roberts, A. J., Janda, K. D. Studies towards the improvement of an anti-cocaine monoclonal antibody for treatment of acute overdose Bioorganic & Medicinal Chemistry Letters  2016 26:5078-5081  DOI:10.1016/j.bmcl.2016.08.081  PMID:27599743  PMCID:PMC5050165
    • degree-related publication Jacob, N. T., Lockner, J. W., Schlosburg, J. E., Ellis, B. A., Eubanks, L. M., Janda, K. D. Investigations of enantiopure nicotine haptens using an adjuvanting carrier in anti-nicotine vaccine development Journal of Medicinal Chemistry  2016 59:2523-2529  DOI:10.1021/acs.jmedchem.5b01676  PMID:26918428
    • Frost, J. R., Jacob, N. T., Papa, L. J., Owens, A. E., Fasan, R. Ribosomal synthesis of macrocyclic peptides in vitro and in vivo mediated by genetically encoded aminothiol unnatural amino acids ACS Chemical Biology  2015 10:1805-1816  DOI:10.1021/acschembio.5b00119  PMID:25933125  PMCID:PMC4546577
    • degree-related publication Jacob, N. T., Lockner, J. W., Kravchenko, V. V., Janda, K. D. Pharmacophore reassignment for induction of the immunosurveillance cytokine TRAIL Angewandte Chemie-International Edition  2014 53:6628-6631  DOI:10.1002/anie.201402133  PMID:24838721
    • Frost, J. R., Vitali, F., Jacob, N. T., Brown, M. D., Fasan, R. Macrocyclization of organo-peptide hybrids through a dual bio-orthogonal ligation: insights from structure-reactivity studies ChemBioChem  2013 14:147-160  DOI:10.1002/cbic.201200579  PMID:23203912
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Background

education and training

  • Ph.D. in Chemical Biology, Scripps Research 2013 - 2018
  • B.S. in Chemistry, University of Rochester 2009 - 2013

advisee of

  • graduate advising relationship

    • Janda, Kim, Ph.D.  candidacy, 2014 - 2018
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Contact

full name

  • Nicholas Taylor Jacob

geographic location

  • Scripps California 

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