recent publications
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academic article
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Jacob, N. T., Miranda, P. O., Shirey, R. J., Gautam, R., Zhou, B., Izquierdo, M. E. D., Hixon, M. S., Hart, J. R., Ueno, L., Vogt, P. K., Janda, K. D. Synthetic molecules for disruption of the MYC protein-protein interface Bioorganic & Medicinal Chemistry 2018 26:4234-4239 DOI:10.1016/j.bmc.2018.07.019 PMID:30037753
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Miranda, P. O., Cubitt, B., Jacob, N. T., Janda, K. D., de la Torre, J. C. Mining a Kröhnke pyridine library for anti-arenavirus activity ACS Infectious Diseases 2018 4:815-824 DOI:10.1021/acsinfecdis.7b00236 PMID:29405696
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Jacob, N. T., Anraku, K., Kimishima, A., Zhou, B., Collins, K. C., Lockner, J. W., Ellis, B. A., Janda, K. D. A bioconjugate leveraging xenoreactive antibodies to alleviate cocaine-induced behavior Chemical Communications 2017 53:8156-8159 DOI:10.1039/c7cc04055e PMID:28677711
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Anraku, K., Sato, S., Jacob, N. T., Eubanks, L. M., Ellis, B. A., Janda, K. D. The design and synthesis of an α-Gal trisaccharide epitope that provides a highly specific anti-Gal immune response Organic & Biomolecular Chemistry 2017 15:2979-2992 DOI:10.1039/c7ob00448f PMID:28294277
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Zhou, B., Eubanks, L. M., Jacob, N. T., Ellis, B., Roberts, A. J., Janda, K. D. Studies towards the improvement of an anti-cocaine monoclonal antibody for treatment of acute overdose Bioorganic & Medicinal Chemistry Letters 2016 26:5078-5081 DOI:10.1016/j.bmcl.2016.08.081 PMID:27599743 PMCID:PMC5050165
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Jacob, N. T., Lockner, J. W., Schlosburg, J. E., Ellis, B. A., Eubanks, L. M., Janda, K. D. Investigations of enantiopure nicotine haptens using an adjuvanting carrier in anti-nicotine vaccine development Journal of Medicinal Chemistry 2016 59:2523-2529 DOI:10.1021/acs.jmedchem.5b01676 PMID:26918428
- Frost, J. R., Jacob, N. T., Papa, L. J., Owens, A. E., Fasan, R. Ribosomal synthesis of macrocyclic peptides in vitro and in vivo mediated by genetically encoded aminothiol unnatural amino acids ACS Chemical Biology 2015 10:1805-1816 DOI:10.1021/acschembio.5b00119 PMID:25933125 PMCID:PMC4546577
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Jacob, N. T., Lockner, J. W., Kravchenko, V. V., Janda, K. D. Pharmacophore reassignment for induction of the immunosurveillance cytokine TRAIL Angewandte Chemie-International Edition 2014 53:6628-6631 DOI:10.1002/anie.201402133 PMID:24838721
- Frost, J. R., Vitali, F., Jacob, N. T., Brown, M. D., Fasan, R. Macrocyclization of organo-peptide hybrids through a dual bio-orthogonal ligation: insights from structure-reactivity studies ChemBioChem 2013 14:147-160 DOI:10.1002/cbic.201200579 PMID:23203912
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