recent publications
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academic article
- Chung, H. W., Petersen, E. N., Cabanos, C., Murphy, K. R., Pavel, M. A., Hansen, A. S., Ja, W. W., Hansen, S. B. A molecular target for an alcohol chain-length cutoff Journal of Molecular Biology 2019 431:196-209 DOI:10.1016/j.jmb.2018.11.028 PMID:30529033 PMCID:PMC6360937
- Chen, Y. C. D., Park, S. J., Joseph, R. M., Ja, W. W., Dahanukar, A. A. Combinatorial pharyngeal taste coding for feeding avoidance in adult Drosophila Cell Reports 2019 29:961-973 DOI:10.1016/j.celrep.2019.09.036 PMID:31644916
- Schinaman, J. M., Rana, A., Ja, W. W., Clark, R. I., Walker, D. W. Rapamycin modulates tissue aging and lifespan independently of the gut microbiota in Drosophila Scientific Reports 2019 9 DOI:10.1038/s41598-019-44106-5 PMID:31127145 PMCID:PMC6534571
- Keebaugh, E. S., Yamada, R., Ja, W. W. The nutritional environment influences the impact of microbes on Drosophila melanogaster life span MBio 2019 10 DOI:10.1128/mBio.00885-19 PMID:31289176
- Obadia, B., Keebaugh, E. S., Yamada, R., Ludington, W. B., Ja, W. W. Diet influences host-microbiota associations in Drosophila Proceedings of the National Academy of Sciences of the United States of America 2018 115:E4547-E4548 DOI:10.1073/pnas.1804948115 PMID:29735646 PMCID:PMC5960334
- Ahmad, M., Keebaugh, E. S., Tariq, M., Ja, W. W. Evolutionary responses of Drosophila melanogaster under chronic malnutrition Frontiers in Ecology and Evolution 2018 6 DOI:10.3389/fevo.2018.00047
- Guan, L., Luo, Y., Ja, W. W., Disney, M. D. Small molecule alteration of RNA sequence in cells and animals Bioorganic & Medicinal Chemistry Letters 2018 28:2794-2796 DOI:10.1016/j.bmcl.2018.10.034 PMID:29079470 PMCID:PMC5906209
- Hughson, B. N., Anreiter, I., Chornenki, N. L. J., Murphy, K. R., Ja, W. W., Huber, R., Sokolowski, M. B. The adult foraging assay (AFA) detects strain and food-deprivation effects in feeding-related traits of Drosophila melanogaster Journal of Insect Physiology 2018 106:20-29 DOI:10.1016/j.jinsphys.2017.08.011 PMID:28860037 PMCID:PMC5832525
- Chen, Y. C. D., Park, S. J., Ja, W. W., Dahanukar, A. Using Pox-Neuro (Poxn) mutants in Drosophila gustation research: a double-edged sword Frontiers in Cellular Neuroscience 2018 12 DOI:10.3389/fncel.2018.00382 PMID:30405359 PMCID:PMC6207628
- Keebaugh, E. S., Ja, W. W. Breaking down walls: Microbiota and the aging gut Cell Host & Microbe 2017 21:417-418 DOI:10.1016/j.chom.2017.03.013 PMID:28407478
- Yamada, R., Deshpande, S. A., Keebaugh, E. S., Ehrlich, M. R., Obando, A. S., Ja, W. W. Mifepristone reduces food palatability and affects drosophila feeding and lifespan Journals of Gerontology Series A-Biological Sciences and Medical Sciences 2017 72:173-180 DOI:10.1093/gerona/glw072 PMID:27093874 PMCID:PMC5233908
- Keebaugh, E. S., Park, J. H., Su, C. C., Yamada, R., Ja, W. W. Nutrition influences caffeine-mediated sleep loss in Drosophila Sleep 2017 40 DOI:10.1093/sleep/zsx146 PMID:29029291
- Obadia, B., Guvener, Z. T., Zhang, V. V., Ceja-Navarro, J. A., Brodie, E. L., Ja, W. W., Ludington, W. B. Probabilistic invasion underlies natural gut microbiome stability Current Biology 2017 27:1999-2006 DOI:10.1016/j.cub.2017.05.034 PMID:28625783
- Murphy, K. R., Park, J. H., Huber, R., Ja, W. W. Simultaneous measurement of sleep and feeding in individual Drosophila Nature Protocols 2017 12:2355-2366 DOI:10.1038/nprot.2017.096 PMID:29022943
- Park, J. H., Carvalho, G. B., Murphy, K. R., Ehrlich, M. R., Ja, W. W. Sucralose suppresses food intake Cell Metabolism 2017 25:484-485 DOI:10.1016/j.cmet.2017.02.011 PMID:28273467
- Carvalho, G. B., Drago, I., Hoxha, S., Yamada, R., Mahneva, O., Bruce, K. D., Obando, A. S., Conti, B., Ja, W. W. The 4E-BP growth pathway regulates the effect of ambient temperature on Drosophila metabolism and lifespan Proceedings of the National Academy of Sciences of the United States of America 2017 114:9737-9742 DOI:10.1073/pnas.1618994114 PMID:28827349
- Ulgherait, M., Chen, A., Oliva, M. K., Kim, H. X., Canman, J. C., Ja, W. W., Shirasu-Hiza, M. Dietary restriction extends the lifespan of circadian mutants tim and per Cell Metabolism 2016 24:763-764 DOI:10.1016/j.cmet.2016.11.002 PMID:27916531
- Keebaugh, E. S., Ja, W. W. Microbes without borders: decompartmentalization of the aging gut Cell Host & Microbe 2016 19:133-135 DOI:10.1016/j.chom.2016.01.016 PMID:26867169
- King, L. B., Koch, M., Murphy, K., Velazquez, Y., Ja, W. W., Tomchik, S. M. Neurofibromin loss of function drives excessive grooming in Drosophila G3-Genes Genomes Genetics 2016 6:1083-1093 DOI:10.1534/g3.115.026484 PMID:26896440 PMCID:PMC4825643
- Murphy, K. R., Deshpande, S. A., Yurgel, M. E., Quinn, J. P., Weissbach, J. L., Keene, A. C., Dawson-Scully, K., Huber, R., Tomchik, S. M., Ja, W. W. Postprandial sleep mechanics in Drosophila Elife 2016 5 DOI:10.7554/eLife.19334 PMID:27873574 PMCID:PMC5119887
- Allen, V. W., O'Connor, R. M., Ulgherait, M., Zhou, C. G., Stone, E. F., Hill, V. M., Murphy, K. R., Canman, J. C., Ja, W. W., Shirasu-Hiza, M. M. period-Regulated feeding behavior and TOR signaling modulate survival of infection Current Biology 2016 26:184-194 DOI:10.1016/j.cub.2015.11.051 PMID:26748856 PMCID:PMC4729625
- Murakami, K., Yurgel, M. E., Stahl, B. A., Masek, P., Mehta, A., Heidker, R., Bollinger, W., Gingras, R. M., Kim, Y. J., Ja, W. W., Suter, B., DiAngelo, J. R., et al. translin is required for metabolic regulation of sleep Current Biology 2016 26:972-980 DOI:10.1016/j.cub.2016.02.013 PMID:27020744 PMCID:PMC4846466
- Deshpande, S. A., Yamada, R., Mak, C. M., Hunter, B., Obando, A. S., Hoxha, S., Ja, W. W. Acidic food pH increases palatability and consumption and extends drosophila lifespan Journal of Nutrition 2015 145:2789-2796 DOI:10.3945/jn.115.222380 PMID:26491123 PMCID:PMC4656910
- Clark, R. I., Salazar, A., Yamada, R., Fitz-Gibbon, S., Morselli, M., Alcaraz, J., Rana, A., Rera, M., Pellegrini, M., Ja, W. W., Walker, D. W. Distinct shifts in microbiota composition during Drosophila aging impair intestinal function and drive mortality Cell Reports 2015 12:1656-1667 DOI:10.1016/j.celrep.2015.08.004 PMID:26321641 PMCID:PMC4565751
- Yamada, R., Deshpande, S. A., Bruce, K. D., Mak, E. M., Ja, W. W. Microbes promote amino acid harvest to rescue undernutrition in Drosophila Cell Reports 2015 10:865-872 DOI:10.1016/j.celrep.2015.01.018 PMID:25683709 PMCID:PMC4534362
- Lin, Y. H., Chen, Y. C., Kao, T. Y., Lin, Y. C., Hsu, T. E., Wu, Y. C., Ja, W. W., Brummel, T. J., Kapahi, P., Yuh, C. H., Yu, L. K., Lin, Z. H., et al. Diacylglycerol lipase regulates lifespan and oxidative stress response by inversely modulating TOR signaling in Drosophila and C. elegans Aging Cell 2014 13:755-764 DOI:10.1111/acel.12232 PMID:24889782 PMCID:PMC4116436
- Deshpandel, S. A., Carvalho, G. B., Amador, A., Phillips, A. M., Hoxha, S., Lizotte, K. J., Ja, W. W. Quantifying Drosophila food intake: comparative analysis of current methodology Nature Methods 2014 11:535-540 DOI:10.1038/nmeth.2899 PMID:24681694 PMCID:PMC4008671
- Bruce, K. D., Hoxha, S., Carvalho, G. B., Yamada, R., Wang, H. D., Karayan, P., He, S., Brummel, T., Kapahi, P., Ja, W. W. High carbohydrate-low protein consumption maximizes Drosophila lifespan Experimental Gerontology 2013 48:1129-1135 DOI:10.1016/j.exger.2013.02.003 PMID:23403040 PMCID:PMC3687007
- Gimenez, L. E. D., Ghildyal, P., Fischer, K. E., Hu, H. X., Ja, W. W., Eaton, B. A., Wu, Y. M., Austad, S. N., Ranjan, R. Modulation of Methuselah expression targeted to Drosophila insulin-producing cells extends life and enhances oxidative stress resistance Aging Cell 2013 12:121-129 DOI:10.1111/acel.12027 PMID:23121290 PMCID:PMC3552032
- Carvalho, G. B., Zid, B. M., Brummel, T., Ja, W. W. Reply to Piper et al.: Drosophila dietary restriction: Does it hold water? Proceedings of the National Academy of Sciences of the United States of America 2010 107:E57 DOI:10.1073/pnas.1002161107 PMCID:PMC2851982
- Carvalho, G. B., Ja, W. W., Benzer, S. Non-lethal PCR genotyping of single Drosophila Biotechniques 2009 46:312-314 DOI:10.2144/000113088 PMID:19450239 PMCID:PMC2793178
- Ja, W. W., Carvalho, G. B., Madrigal, M., Roberts, R. W., Benzer, S. The Drosophila G protein-coupled receptor, Methuselah, exhibits a promiscuous response to peptides Protein Science 2009 18:2203-2208 DOI:10.1002/pro.221 PMID:19672878 PMCID:PMC2788275
- Ja, W. W., Carvalho, G. B., Zid, B. M., Mak, E. M., Brummel, T., Benzer, S. Water- and nutrient-dependent effects of dietary restriction on Drosophila lifespan Proceedings of the National Academy of Sciences of the United States of America 2009 106:18633-18637 DOI:10.1073/pnas.0908016106 PMID:19841272 PMCID:PMC2773996
- Austin, R. J., Ja, W. W., Roberts, R. W. Evolution of class-specific peptides targeting a hot spot of the Galphas subunit Journal of Molecular Biology 2008 377:1406-1418 DOI:10.1016/j.jmb.2008.01.032 PMID:18329041 PMCID:PMC2891084
- Carvalho, G. B., Ja, W. W., Kapahi, P., Benzer, S. Reply to: Pitfalls of measuring feeding rate in the fruit fly Drosophila melanogaster Nature Methods 2008 5:215 DOI:10.1038/nmeth0308-215 PMID:18309307
- Heo, J., Ja, W. W., Benzer, S., Goddard, W. A. The predicted binding site and dynamics of peptide inhibitors to the Methuselah GPCR from Drosophila melanogaster Biochemistry 2008 47:12740-12749 DOI:10.1021/bi801335p PMID:18991399 PMCID:PMC2900200
- Ja, W. W., West, A. P., Delker, S. L., Bjorkman, P. J., Benzer, S., Roberts, R. W. Extension of Drosophila melanogaster life span with a GPCR peptide inhibitor Nature Chemical Biology 2007 3:415-419 DOI:10.1038/nchembio.2007-2 PMID:17546039 PMCID:PMC2803097
- Ja, W. W., Carvalho, G. B., Mak, E. M., de la Rosa, N. N., Fang, A. Y., Liong, J. C., Brummel, T., Benzer, S. Prandiology of Drosophila and the CAFE assay Proceedings of the National Academy of Sciences of the United States of America 2007 104:8253-8256 DOI:10.1073/pnas.0702726104 PMID:17494737 PMCID:PMC1899109
- Wiser, O., Qian, X., Ehlers, M., Ja, W. W., Roberts, R. W., Reuveny, E., Jan, Y. N., Jan, L. Y. Modulation of basal and receptor-induced GIRK potassium channel activity and neuronal excitability by the mammalian PINS homolog LGN Neuron 2006 50:561-573 DOI:10.1016/j.neuron.2006.03.046 PMID:16701207
- Ja, W. W., Wiser, O., Austin, R. J., Jan, L. Y., Roberts, R. W. Turning G proteins on and off using peptide ligands ACS Chemical Biology 2006 1:570-574 DOI:10.1021/cb600345k PMID:17168552 PMCID:PMC2802464
- Ja, W. W., Adhikari, A., Austin, R. J., Sprang, S. R., Roberts, R. W. A peptide core motif for binding to heterotrimeric G protein α subunits Journal of Biological Chemistry 2005 280:32057-32060 DOI:10.1074/jbc.C500319200 PMID:16051611
- Ja, W. W., Olsen, B. N., Roberts, R. W. Epitope mapping using mRNA display and a unidirectional nested deletion library Protein Engineering Design & Selection 2005 18:309-319 DOI:10.1093/protein/gzi038 PMID:15980016 PMCID:PMC2798801
- Ja, W. W., Roberts, R. W. G-protein-directed ligand discovery with peptide combinatorial libraries Trends in Biochemical Sciences 2005 30:318-324 DOI:10.1016/j.tibs.2005.04.001 PMID:15950876
- Ja, W. W., Roberts, R. W. In vitro selection of state-specific peptide modulators of G protein signaling using mRNA display Biochemistry 2004 43:9265-9275 DOI:10.1021/bi0498398 PMID:15248784
- Roberts, R. W., Ja, W. W. In vitro selection of nucleic acids and proteins: what are we learning? Current Opinion in Structural Biology 1999 9:521-529 DOI:10.1016/s0959-440x(99)80074-8 PMID:10449375
- Liu, S. R., Shi, Y. N., Ja, W. W., Mathies, R. A. Optimization of high-speed DNA sequencing on microfabricated capillary electrophoresis channels Analytical Chemistry 1999 71:566-573 DOI:10.1021/ac980783v PMID:9989377
- Scherer, J. R., Kheterpal, I., Radhakrishnan, A., Ja, W. W., Mathies, R. A. Ultra-high throughput rotary capillary array electrophoresis scanner for fluorescent DNA sequencing and analysis Electrophoresis 1999 20:1508-1517 DOI:10.1002/(sici)1522-2683(19990601)20:7<1508::aid-elps1508>3.3.co;2-z PMID:10424474
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