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Ja, William
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Ja, William

Faculty Member
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Positions

  • 2017 - Associate Professor, Neuroscience , Scripps Research
  • 2017 - Associate Professor (Joint Appointment), Molecular Medicine , Scripps Research
  • 2010 - Faculty Member, Skaggs Graduate School of Chemical and Biological Sciences , Scripps Research
  • 2015 - 2017 Associate Professor, Metabolism and Aging , Scripps Research
  • 2010 - 2015 Assistant Professor, Metabolism and Aging , Scripps Research
  • 2005 - 2009 Postdoctoral Scholar in Biology with Dr. Seymour Benzer, California Institute of Technology

Research Areas research areas

  • Aging (UMLS)
  • Diabetes (UMLS)
  • nutrition (UMLS)

Contact

  • wja@scripps.edu

Websites

  • William Ja, Ph.D.
  • Laboratory Website
  • Publications
  • Research
  • Teaching
  • Background
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Publications

recent publications
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  • Publications without PubMed PMIDs

  • academic article

    • Hoxha, S., Shepard, A., Troutman, S., Diao, H., Doherty, J. R., Janiszewska, M., Witwicki, R. M., Pipkin, M. E., Ja, W. W., Kareta, M. S., Kissil, J. L. YAP-Mediated Recruitment of YY1 and EZH2 Represses Transcription of Key Cell-Cycle Regulators Cancer Research  2020 80:2512-2522  DOI:10.1158/0008-5472.Can-19-2415  PMID:32409309  PMCID:PMC7299785
    • Park, S. J. (173266 ), Ja, W. W. Absolute ethanol intake predicts ethanol preference in Drosophila melanogaster Journal of Experimental Biology  2020 223  DOI:10.1242/jeb.224121  PMID:32366685  PMCID:PMC7295594
    • Wang, Q. P., Lin, Y. Q., Lai, M. L., Su, Z., Oyston, L. J., Clark, T., Park, S. J., Khuong, T. M., Lau, M. T., Shenton, V., Shi, Y. C., James, D. E., et al. PGC1α controls sucrose taste sensitization in drosophila Cell Reports  2020 31  DOI:10.1016/j.celrep.2020.03.044  PMID:32268099
    • Ludington, W. B., Ja, W. W. Drosophila as a model for the gut microbiome Plos Pathogens  2020 16  DOI:10.1371/journal.ppat.1008398  PMID:32324814  PMCID:PMC7179820
    • Wu, Q., Yu, G., Park, S. J. (173266 ), Gao, Y., Ja, W. W., Yang, M. Excreta quantification (EX-Q) for longitudinal measurements of food intake in Drosophila iScience  2020 23  DOI:10.1016/j.isci.2019.100776  PMID:31901635  PMCID:PMC6941854
    • Chen, Y. C. D., Park, S. J., Joseph, R. M., Ja, W. W., Dahanukar, A. A. Combinatorial pharyngeal taste coding for feeding avoidance in adult Drosophila Cell Reports  2019 29:961-973  DOI:10.1016/j.celrep.2019.09.036  PMID:31644916
    • Keebaugh, E. S., Yamada, R., Ja, W. W. The nutritional environment influences the impact of microbes on Drosophila melanogaster life span MBio  2019 10  DOI:10.1128/mBio.00885-19  PMID:31289176
    • Schinaman, J. M., Rana, A., Ja, W. W., Clark, R. I., Walker, D. W. Rapamycin modulates tissue aging and lifespan independently of the gut microbiota in Drosophila Scientific Reports  2019 9  DOI:10.1038/s41598-019-44106-5  PMID:31127145  PMCID:PMC6534571
    • Chung, H. W., Petersen, E. N., Cabanos, C., Murphy, K. R., Pavel, M. A., Hansen, A. S., Ja, W. W., Hansen, S. B. A molecular target for an alcohol chain-length cutoff Journal of Molecular Biology  2019 431:196-209  DOI:10.1016/j.jmb.2018.11.028  PMID:30529033  PMCID:PMC6360937
    • Chen, Y. C. D., Park, S. J., Ja, W. W., Dahanukar, A. Using Pox-Neuro (Poxn) mutants in Drosophila gustation research: a double-edged sword Frontiers in Cellular Neuroscience  2018 12  DOI:10.3389/fncel.2018.00382  PMID:30405359  PMCID:PMC6207628
    • Guan, L., Luo, Y., Ja, W. W., Disney, M. D. Small molecule alteration of RNA sequence in cells and animals Bioorganic & Medicinal Chemistry Letters  2018 28:2794-2796  DOI:10.1016/j.bmcl.2018.10.034  PMID:29079470  PMCID:PMC5906209
    • Obadia, B., Keebaugh, E. S., Yamada, R., Ludington, W. B., Ja, W. W. Diet influences host-microbiota associations in Drosophila Proceedings of the National Academy of Sciences of the United States of America  2018 115:E4547-E4548  DOI:10.1073/pnas.1804948115  PMID:29735646  PMCID:PMC5960334
    • Ahmad, M., Keebaugh, E. S., Tariq, M., Ja, W. W. Evolutionary responses of Drosophila melanogaster under chronic malnutrition Frontiers in Ecology and Evolution  2018 6  DOI:10.3389/fevo.2018.00047
    • Hughson, B. N., Anreiter, I., Chornenki, N. L. J., Murphy, K. R., Ja, W. W., Huber, R., Sokolowski, M. B. The adult foraging assay (AFA) detects strain and food-deprivation effects in feeding-related traits of Drosophila melanogaster Journal of Insect Physiology  2018 106:20-29  DOI:10.1016/j.jinsphys.2017.08.011  PMID:28860037  PMCID:PMC5832525
    • Keebaugh, E. S., Park, J. H., Su, C. C., Yamada, R., Ja, W. W. Nutrition influences caffeine-mediated sleep loss in Drosophila Sleep  2017 40  DOI:10.1093/sleep/zsx146  PMID:29029291
    • Murphy, K. R., Park, J. H., Huber, R., Ja, W. W. Simultaneous measurement of sleep and feeding in individual Drosophila Nature Protocols  2017 12:2355-2366  DOI:10.1038/nprot.2017.096  PMID:29022943
    • Carvalho, G. B., Drago, I., Hoxha, S., Yamada, R., Mahneva, O., Bruce, K. D., Obando, A. S., Conti, B., Ja, W. W. The 4E-BP growth pathway regulates the effect of ambient temperature on Drosophila metabolism and lifespan Proceedings of the National Academy of Sciences of the United States of America  2017 114:9737-9742  DOI:10.1073/pnas.1618994114  PMID:28827349
    • Obadia, B., Guvener, Z. T., Zhang, V. V., Ceja-Navarro, J. A., Brodie, E. L., Ja, W. W., Ludington, W. B. Probabilistic invasion underlies natural gut microbiome stability Current Biology  2017 27:1999-2006  DOI:10.1016/j.cub.2017.05.034  PMID:28625783
    • Keebaugh, E. S., Ja, W. W. Breaking down walls: Microbiota and the aging gut Cell Host & Microbe  2017 21:417-418  DOI:10.1016/j.chom.2017.03.013  PMID:28407478
    • Park, J. H., Carvalho, G. B., Murphy, K. R., Ehrlich, M. R., Ja, W. W. Sucralose suppresses food intake Cell Metabolism  2017 25:484-485  DOI:10.1016/j.cmet.2017.02.011  PMID:28273467
    • Yamada, R., Deshpande, S. A., Keebaugh, E. S., Ehrlich, M. R., Obando, A. S., Ja, W. W. Mifepristone reduces food palatability and affects drosophila feeding and lifespan Journals of Gerontology Series A-Biological Sciences and Medical Sciences  2017 72:173-180  DOI:10.1093/gerona/glw072  PMID:27093874  PMCID:PMC5233908
    • Ulgherait, M., Chen, A., Oliva, M. K., Kim, H. X., Canman, J. C., Ja, W. W., Shirasu-Hiza, M. Dietary restriction extends the lifespan of circadian mutants tim and per Cell Metabolism  2016 24:763-764  DOI:10.1016/j.cmet.2016.11.002  PMID:27916531
    • Murphy, K. R., Deshpande, S. A., Yurgel, M. E., Quinn, J. P., Weissbach, J. L., Keene, A. C., Dawson-Scully, K., Huber, R., Tomchik, S. M., Ja, W. W. Postprandial sleep mechanics in Drosophila Elife  2016 5  DOI:10.7554/eLife.19334  PMID:27873574  PMCID:PMC5119887
    • Murakami, K., Yurgel, M. E., Stahl, B. A., Masek, P., Mehta, A., Heidker, R., Bollinger, W., Gingras, R. M., Kim, Y. J., Ja, W. W., Suter, B., DiAngelo, J. R., et al. translin is required for metabolic regulation of sleep Current Biology  2016 26:972-980  DOI:10.1016/j.cub.2016.02.013  PMID:27020744  PMCID:PMC4846466
    • King, L. B., Koch, M., Murphy, K., Velazquez, Y., Ja, W. W., Tomchik, S. M. Neurofibromin loss of function drives excessive grooming in Drosophila G3-Genes Genomes Genetics  2016 6:1083-1093  DOI:10.1534/g3.115.026484  PMID:26896440  PMCID:PMC4825643
    • Keebaugh, E. S., Ja, W. W. Microbes without borders: decompartmentalization of the aging gut Cell Host & Microbe  2016 19:133-135  DOI:10.1016/j.chom.2016.01.016  PMID:26867169
    • Allen, V. W., O'Connor, R. M., Ulgherait, M., Zhou, C. G., Stone, E. F., Hill, V. M., Murphy, K. R., Canman, J. C., Ja, W. W., Shirasu-Hiza, M. M. period-Regulated feeding behavior and TOR signaling modulate survival of infection Current Biology  2016 26:184-194  DOI:10.1016/j.cub.2015.11.051  PMID:26748856  PMCID:PMC4729625
    • Deshpande, S. A., Yamada, R., Mak, C. M., Hunter, B., Obando, A. S., Hoxha, S., Ja, W. W. Acidic food pH increases palatability and consumption and extends drosophila lifespan Journal of Nutrition  2015 145:2789-2796  DOI:10.3945/jn.115.222380  PMID:26491123  PMCID:PMC4656910
    • Clark, R. I., Salazar, A., Yamada, R., Fitz-Gibbon, S., Morselli, M., Alcaraz, J., Rana, A., Rera, M., Pellegrini, M., Ja, W. W., Walker, D. W. Distinct shifts in microbiota composition during Drosophila aging impair intestinal function and drive mortality Cell Reports  2015 12:1656-1667  DOI:10.1016/j.celrep.2015.08.004  PMID:26321641  PMCID:PMC4565751
    • Yamada, R., Deshpande, S. A., Bruce, K. D., Mak, E. M., Ja, W. W. Microbes promote amino acid harvest to rescue undernutrition in Drosophila Cell Reports  2015 10:865-872  DOI:10.1016/j.celrep.2015.01.018  PMID:25683709  PMCID:PMC4534362
    • Lin, Y. H., Chen, Y. C., Kao, T. Y., Lin, Y. C., Hsu, T. E., Wu, Y. C., Ja, W. W., Brummel, T. J., Kapahi, P., Yuh, C. H., Yu, L. K., Lin, Z. H., et al. Diacylglycerol lipase regulates lifespan and oxidative stress response by inversely modulating TOR signaling in Drosophila and C. elegans Aging Cell  2014 13:755-764  DOI:10.1111/acel.12232  PMID:24889782  PMCID:PMC4116436
    • Deshpandel, S. A., Carvalho, G. B., Amador, A., Phillips, A. M., Hoxha, S., Lizotte, K. J., Ja, W. W. Quantifying Drosophila food intake: comparative analysis of current methodology Nature Methods  2014 11:535-540  DOI:10.1038/nmeth.2899  PMID:24681694  PMCID:PMC4008671
    • Bruce, K. D., Hoxha, S., Carvalho, G. B., Yamada, R., Wang, H. D., Karayan, P., He, S., Brummel, T., Kapahi, P., Ja, W. W. High carbohydrate-low protein consumption maximizes Drosophila lifespan Experimental Gerontology  2013 48:1129-1135  DOI:10.1016/j.exger.2013.02.003  PMID:23403040  PMCID:PMC3687007
    • Gimenez, L. E. D., Ghildyal, P., Fischer, K. E., Hu, H. X., Ja, W. W., Eaton, B. A., Wu, Y. M., Austad, S. N., Ranjan, R. Modulation of Methuselah expression targeted to Drosophila insulin-producing cells extends life and enhances oxidative stress resistance Aging Cell  2013 12:121-129  DOI:10.1111/acel.12027  PMID:23121290  PMCID:PMC3552032
    • Carvalho, G. B., Zid, B. M., Brummel, T., Ja, W. W. Reply to Piper et al.: Drosophila dietary restriction: Does it hold water? Proceedings of the National Academy of Sciences of the United States of America  2010 107:E57  DOI:10.1073/pnas.1002161107  PMCID:PMC2851982
    • Ja, W. W., Carvalho, G. B., Zid, B. M., Mak, E. M., Brummel, T., Benzer, S. Water- and nutrient-dependent effects of dietary restriction on Drosophila lifespan Proceedings of the National Academy of Sciences of the United States of America  2009 106:18633-18637  DOI:10.1073/pnas.0908016106  PMID:19841272  PMCID:PMC2773996
    • Ja, W. W., Carvalho, G. B., Madrigal, M., Roberts, R. W., Benzer, S. The Drosophila G protein-coupled receptor, Methuselah, exhibits a promiscuous response to peptides Protein Science  2009 18:2203-2208  DOI:10.1002/pro.221  PMID:19672878  PMCID:PMC2788275
    • Carvalho, G. B., Ja, W. W., Benzer, S. Non-lethal PCR genotyping of single Drosophila Biotechniques  2009 46:312-314  DOI:10.2144/000113088  PMID:19450239  PMCID:PMC2793178
    • Heo, J., Ja, W. W., Benzer, S., Goddard, W. A. The predicted binding site and dynamics of peptide inhibitors to the Methuselah GPCR from Drosophila melanogaster Biochemistry  2008 47:12740-12749  DOI:10.1021/bi801335p  PMID:18991399  PMCID:PMC2900200
    • Austin, R. J., Ja, W. W., Roberts, R. W. Evolution of class-specific peptides targeting a hot spot of the Galphas subunit Journal of Molecular Biology  2008 377:1406-1418  DOI:10.1016/j.jmb.2008.01.032  PMID:18329041  PMCID:PMC2891084
    • Carvalho, G. B., Ja, W. W., Kapahi, P., Benzer, S. Reply to: Pitfalls of measuring feeding rate in the fruit fly Drosophila melanogaster Nature Methods  2008 5:215  DOI:10.1038/nmeth0308-215  PMID:18309307
    • Ja, W. W., West, A. P., Delker, S. L., Bjorkman, P. J., Benzer, S., Roberts, R. W. Extension of Drosophila melanogaster life span with a GPCR peptide inhibitor Nature Chemical Biology  2007 3:415-419  DOI:10.1038/nchembio.2007-2  PMID:17546039  PMCID:PMC2803097
    • Ja, W. W., Carvalho, G. B., Mak, E. M., de la Rosa, N. N., Fang, A. Y., Liong, J. C., Brummel, T., Benzer, S. Prandiology of Drosophila and the CAFE assay Proceedings of the National Academy of Sciences of the United States of America  2007 104:8253-8256  DOI:10.1073/pnas.0702726104  PMID:17494737  PMCID:PMC1899109
    • Wiser, O., Qian, X., Ehlers, M., Ja, W. W., Roberts, R. W., Reuveny, E., Jan, Y. N., Jan, L. Y. Modulation of basal and receptor-induced GIRK potassium channel activity and neuronal excitability by the mammalian PINS homolog LGN Neuron  2006 50:561-573  DOI:10.1016/j.neuron.2006.03.046  PMID:16701207
    • Ja, W. W., Wiser, O., Austin, R. J., Jan, L. Y., Roberts, R. W. Turning G proteins on and off using peptide ligands ACS Chemical Biology  2006 1:570-574  DOI:10.1021/cb600345k  PMID:17168552  PMCID:PMC2802464
    • Ja, W. W., Adhikari, A., Austin, R. J., Sprang, S. R., Roberts, R. W. A peptide core motif for binding to heterotrimeric G protein α subunits Journal of Biological Chemistry  2005 280:32057-32060  DOI:10.1074/jbc.C500319200  PMID:16051611
    • Ja, W. W., Olsen, B. N., Roberts, R. W. Epitope mapping using mRNA display and a unidirectional nested deletion library Protein Engineering Design & Selection  2005 18:309-319  DOI:10.1093/protein/gzi038  PMID:15980016  PMCID:PMC2798801
    • Ja, W. W., Roberts, R. W. G-protein-directed ligand discovery with peptide combinatorial libraries Trends in Biochemical Sciences  2005 30:318-324  DOI:10.1016/j.tibs.2005.04.001  PMID:15950876
    • Ja, W. W., Roberts, R. W. In vitro selection of state-specific peptide modulators of G protein signaling using mRNA display Biochemistry  2004 43:9265-9275  DOI:10.1021/bi0498398  PMID:15248784
    • Roberts, R. W., Ja, W. W. In vitro selection of nucleic acids and proteins: what are we learning? Current Opinion in Structural Biology  1999 9:521-529  DOI:10.1016/s0959-440x(99)80074-8  PMID:10449375
    • Scherer, J. R., Kheterpal, I., Radhakrishnan, A., Ja, W. W., Mathies, R. A. Ultra-high throughput rotary capillary array electrophoresis scanner for fluorescent DNA sequencing and analysis Electrophoresis  1999 20:1508-1517  DOI:10.1002/(sici)1522-2683(19990601)20:7<1508::aid-elps1508>3.3.co;2-z  PMID:10424474
    • Liu, S. R., Shi, Y. N., Ja, W. W., Mathies, R. A. Optimization of high-speed DNA sequencing on microfabricated capillary electrophoresis channels Analytical Chemistry  1999 71:566-573  DOI:10.1021/ac980783v  PMID:9989377
  • thesis

    • Peptide modulators of G protein signaling 2005

featured in

  • New Scripps Florida Scientist Awarded Pair of Unconventional Grants  News Release
  • Scripps Research Names Innovative Molecular Biologist to Metabolism & Aging Department  News Release
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Research

research overview

  • Over a century of research on the fruit fly has resulted in profound discoveries in basic cellular processes, and has enabled the use of Drosophila as a model for human disease and drug discovery. Our laboratory uses diverse tools in chemistry and biology to dissect genetic pathways that are involved in health and aging. We are currently involved in two major directions:

    1. Interactions of symbiotic microorganisms with Drosophila

    The presence of bacteria during fly lifespan can promote longevity. Our studies will establish the molecular relationship between the fly microbiome, nutrition, and host health and aging. Projects include phylogenetic and genomic studies, analyses of host and bacterial gene expression, and genetic manipulation of candidate host mechanisms for modulating the gut microbiota.

    2. Genetic pathways involved with aging and nutrition

    We have identified candidate genes that modify lifespan in response to nutrition, mimicking the effects of dietary restriction. The mechanistic analysis of these genetic pathways includes application of large-scale methods (metabolomics, lipidomics) and gene expression studies on Drosophila mutants. We are also investigating small molecule-modulators of mitochondrial function in cell culture models of aging.

keywords

  • metabolomics
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Teaching

advisees

  • graduate advising relationship

    • Park, Jin Hong (Scarlett), Ph.D.  candidate, 2017 -
    • Amador, Ariadna, Ph.D.  candidate, 2011 - 2016
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Background

education and training

  • Ph.D. in Chemistry, California Institute of Technology , with Dr. Richard W. Roberts 2004
  • B.S. in Chemistry, University of California, Berkeley , with Dr. Richard A. Mathies and Dr. Alexander N. Glazer 1998
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Contact

full name

  • William W. Ja

geographic location

  • Scripps Florida 

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