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Iacovoni, Jason Scott

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• Bioinformatics Core Facility Manager, University of Toulouse

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• Doctoral Dissertation

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Publications

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  • Montastier, E., Beuzelin, D., Martins, F., Mir, L., Marques, M. A., Thalamas, C., Iacovoni, J., Langin, D., Viguerie, N. Niacin induces miR-502-3p expression which impairs insulin sensitivity in human adipocytes International Journal of Obesity  2019 43:1485-1490  DOI:10.1038/s41366-018-0260-5  PMID:30482933
  • Barquissau, V., Leger, B., Beuzelin, D., Martins, F., Amri, E. Z., Pisani, D. F., Saris, W. H. M., Astrup, A., Maoret, J. J., Iacovoni, J., Dejean, S., Moro, C., et al. Caloric restriction and diet-induced weight loss do not induce browning of human subcutaneous white adipose tissue in women and men with obesity Cell Reports  2018 22:1079-1089  DOI:10.1016/j.celrep.2017.12.102  PMID:29386128
  • Clouaire, T., Rocher, V., Lashgari, A., Arnould, C., Aguirrebengoa, M., Biernacka, A., Skrzypczak, M., Aymard, F., Fongang, B., Dojer, N., Iacovoni, J. S., Rowicka, M., et al. Comprehensive mapping of histone modifications at DNA double-strand breaks deciphers repair pathway chromatin signatures Molecular Cell  2018 72:250-262  DOI:10.1016/j.molcel.2018.08.020  PMID:30270107  PMCID:PMC6202423
  • Fawal, M. A., Jungas, T., Kischel, A., Audouard, C., Iacovoni, J. S., Davy, A. Cross talk between one-carbon metabolism, Eph signaling, and histone methylation promotes neural stem cell differentiation Cell Reports  2018 23:2864-2873  DOI:10.1016/j.celrep.2018.05.005  PMID:29874574
  • Ric, A., Ecochard, V., Iacovoni, J. S., Boutonnet, A., Ginot, F., Ong-Meang, V., Poinsot, V., Paquereau, L., Couderc, F. G-quadruplex aptamer selection using capillary electrophoresis-LED-induced fluorescence and Illumina sequencing Analytical and Bioanalytical Chemistry  2018 410:1991-2000  DOI:10.1007/s00216-018-0865-5  PMID:29380016
  • Farge, T., Saland, E., de Toni, F., Aroua, N., Hosseini, M., Perry, R., Bosc, C., Sugita, M., Stuani, L., Fraisse, M., Scotland, S., Larrue, C., et al. Chemotherapy-resistant human acute myeloid leukemia cells are not enriched for leukemic stem cells but require oxidative metabolism Cancer Discovery  2017 7:716-735  DOI:10.1158/2159-8290.Cd-16-0441  PMID:28416471  PMCID:PMC5501738
  • Aymard, F., Aguirrebengoa, M., Guillou, E., Javierre, B. M., Bugler, B., Arnould, C., Rocher, V., Iacovoni, J. S., Biernacka, A., Skrzypczak, M., Ginalski, K., Rowicka, M., et al. Genome-wide mapping of long-range contacts unveils clustering of DNA double-strand breaks at damaged active genes Nature Structural & Molecular Biology  2017 24:353-361  DOI:10.1038/nsmb.3387  PMID:28263325  PMCID:PMC5385132
  • Bolton, J., Montastier, E., Carayol, J., Bonnel, S., Mir, L., Marques, M. A., Astrup, A., Saris, W., Iacovoni, J., Villa-Vialaneix, N., Valsesia, A., Langin, D., et al. Molecular biomarkers for weight control in obese individuals subjected to a multiphase dietary intervention Journal of Clinical Endocrinology & Metabolism  2017 102:2751-2761  DOI:10.1210/jc.2016-3997  PMID:28482007
  • Nicolas, S., Blasco-Baque, V., Fournel, A., Gilleron, J., Klopp, P., Waget, A., Ceppo, F., Marlin, A., Padmanabhan, R., Iacovoni, J. S., Terce, F., Cani, P. D., et al. Transfer of dysbiotic gut microbiota has beneficial effects on host liver metabolism Molecular Systems Biology  2017 13  DOI:10.15252/msb.20167356  PMID:28302863  PMCID:PMC5371731
  • Branchereau, M., Reichardt, F., Loubieres, P., Marck, P., Waget, A., Azalbert, V., Colom, A., Padmanabhan, R., Iacovoni, J. S., Giry, A., Terce, F., Heymes, C., et al. Periodontal dysbiosis linked to periodontitis is associated with cardiometabolic adaptation to high-fat diet in mice American Journal of Physiology-Gastrointestinal and Liver Physiology  2016 310:G1091-G1101  DOI:10.1152/ajpgi.00424.2015  PMID:27033119
  • Cammas, A., Lacroix-Triki, M., Pierredon, S., Le Bras, M., Iacovoni, J. S., Teulade-Fichou, M. P., Favre, G., Roche, H., Filleron, T., Millevoi, S., Vagner, S. hnRNP A1-mediated translational regulation of the G quadruplex-containing RON receptor tyrosine kinase mRNA linked to tumor progression Oncotarget  2016 7:16793-16805  PMID:26930004  PMCID:PMC4941351
  • Esteve, D., Boulet, N., Volat, F., Zakaroff-Girard, A., Ledoux, S., Coupaye, M., Decaunes, P., Belles, C., Gaits-Iacovoni, F., Iacovoni, J. S., Remaury, A., Castel, B., et al. Human white and brite adipogenesis is supported by MSCA1 and is impaired by immune cells Stem Cells  2015 33:1277-1291  DOI:10.1002/stem.1916  PMID:25523907
  • Caron, P., Choudjaye, J., Clouaire, T., Bugler, B., Daburon, V., Aguirrebengoa, M., Mangeat, T., Iacovoni, J. S., Alvarez-Quilon, A., Cortes-Ledesma, F., Legube, G. Non-redundant functions of ATM and DNA-PKcs in response to DNA double-strand breaks Cell Reports  2015 13:1-12  DOI:10.1016/j.celrep.2015.10.024  PMID:26586426  PMCID:PMC4670905
  • Belliere, J., Casemayou, A., Ducasse, L., Zakaroff-Girard, A., Martins, F., Iacovoni, J. S., Guilbeau-Frugier, C., Buffin-Meyer, B., Pipy, B., Chauveau, D., Schanstra, J. P., Bascands, J. L. Specific macrophage subtypes influence the progression of rhabdomyolysis-induced kidney injury Journal of the American Society of Nephrology  2015 26:1363-1377  DOI:10.1681/asn.2014040320  PMID:25270069  PMCID:PMC4446873
  • Garidou, L., Pomie, C., Klopp, P., Waget, A., Charpentier, J., Aloulou, M., Giry, A., Serino, M., Stenman, L., Lahtinen, S., Dray, C., Iacovoni, J. S., et al. The gut microbiota regulates intestinal CD4 T cells expressing RORγt and controls metabolic disease Cell Metabolism  2015 22:100-112  DOI:10.1016/j.cmet.2015.06.001  PMID:26154056
  • Aymard, F., Bugler, B., Schmidt, C. K., Guillou, E., Caron, P., Briois, S., Iacovoni, J. S., Daburon, V., Miller, K. M., Jackson, S. P., Legube, G. Transcriptionally active chromatin recruits homologous recombination at DNA double-strand breaks Nature Structural & Molecular Biology  2014 21:366-374  DOI:10.1038/nsmb.2796  PMID:24658350  PMCID:PMC4300393
  • Caron, P., Aymard, F., Iacovoni, J. S., Briois, S., Canitrot, Y., Bugler, B., Massip, L., Losada, A., Legube, G. Cohesin protects genes against γH2AX Induced by DNA double-strand breaks PLoS Genetics  2012 8  DOI:10.1371/journal.pgen.1002460  PMID:22275873  PMCID:PMC3261922
  • Laurell, H., Iacovoni, J. S., Abot, A., Svec, D., Maoret, J. J., Arnal, J. F., Kubista, M. Correction of RT-qPCR data for genomic DNA-derived signals with ValidPrime Nucleic Acids Research  2012 40  DOI:10.1093/nar/gkr1259  PMID:22228834  PMCID:PMC3326333
  • Viguerie, N., Montastier, E., Maoret, J. J., Roussel, B., Combes, M., Valle, C., Villa-Vialaneix, N., Iacovoni, J. S., Martinez, J. A., Holst, C., Astrup, A., Vidal, H., et al. Determinants of human adipose tissue gene expression: Impact of diet, sex, metabolic status, and cis genetic regulation PLoS Genetics  2012 8  DOI:10.1371/journal.pgen.1002959  PMID:23028366  PMCID:PMC3459935
  • Serino, M., Luche, E., Gres, S., Baylac, A., Berge, M., Cenac, C., Waget, A., Klopp, P., Iacovoni, J., Klopp, C., Mariette, J., Bouchez, O., et al. Metabolic adaptation to a high-fat diet is associated with a change in the gut microbiota Gut  2012 61:543-553  DOI:10.1136/gutjnl-2011-301012  PMID:22110050  PMCID:PMC3292714
  • Viguerie, N., Picard, F., Hul, G., Roussel, B., Barbe, P., Iacovoni, J. S., Valle, C., Langin, D., Saris, W. H. M. Multiple effects of a short-term dexamethasone treatment in human skeletal muscle and adipose tissue Physiological Genomics  2012 44:141-151  DOI:10.1152/physiolgenomics.00032.2011  PMID:22108209
  • Smih, F., Desmoulin, F., Berry, M., Turkieh, A., Harmancey, R., Iacovoni, J., Trouillet, C., Delmas, C., Pathak, A., Lairez, O., Koukoui, F., Massabuau, P., et al. Blood signature of pre-heart failure: a microarrays study PLoS One  2011 6  DOI:10.1371/journal.pone.0020414  PMID:21731613  PMCID:PMC3123284
  • Glorian, V., Maillot, G., Poles, S., Iacovoni, J. S., Favre, G., Vagner, S. HuR-dependent loading of miRNA RISC to the mRNA encoding the Ras-related small GTPase RhoB controls its translation during UV-induced apoptosis Cell Death and Differentiation  2011 18:1692-1701  DOI:10.1038/cdd.2011.35  PMID:21527938  PMCID:PMC3190107
  • Amar, J., Serino, M., Lange, C., Chabo, C., Iacovoni, J., Mondot, S., Lepage, P., Klopp, C., Mariette, J., Bouchez, O., Perez, L., Courtney, M., et al. Involvement of tissue bacteria in the onset of diabetes in humans: evidence for a concept Diabetologia  2011 54:3055-3061  DOI:10.1007/s00125-011-2329-8  PMID:21976140
  • Massip, L., Caron, P., Iacovoni, J. S., Trouche, D., Legube, G. Deciphering the chromatin landscape induced around DNA double strand breaks Cell Cycle  2010 9:2963-2972  DOI:10.4161/cc.9.15.12412  PMID:20714222
  • Iacovoni, J. S., Caron, P., Lassadi, I., Nicolas, E., Massip, L., Trouche, D., Legube, G. High‐resolution profiling of γH2AX around DNA double strand breaks in the mammalian genome EMBO Journal  2010 29:1446-1457  DOI:10.1038/emboj.2010.38  PMID:20360682  PMCID:PMC2868577
  • Millevoi, S., Decorsiere, A., Loulergue, C., Iacovoni, J., Bernat, S., Antoniou, M., Vagner, S. A physical and functional link between splicing factors promotes pre-mRNA 3' end processing Nucleic Acids Research  2009 37:4672-4683  DOI:10.1093/nar/gkp470  PMID:19506027  PMCID:PMC2724285
  • Montfort, A., de Badts, B., Douin-Echinard, V., Martin, P. G. P., Iacovoni, J., Nevoit, C., Therville, N., Garcia, V., Bertrand, M. A., Bessieres, M. H., Trombe, M. C., Levade, T., et al. FAN stimulates TNFα-induced gene expression, leukocyte recruitment, and humoral response Journal of Immunology  2009 183:5369-5378  DOI:10.4049/jimmunol.0803384  PMID:19786552
  • Karaa, Z. S., Iacovoni, J. S., Bastide, A., Lacazette, E., Touriol, C., Prats, H. The VEGF IRESes are differentially susceptible to translation inhibition by miR-16 RNA-A Publication of the RNA Society  2009 15:249-254  DOI:10.1261/rna.1301109  PMID:19144909  PMCID:PMC2648711
  • Girousse, A., Tavernier, G., Tiraby, C., Lichtenstein, L., Iacovoni, J. S., Mairal, A., Villarroya, F., Langin, D. Transcription of the human uncoupling protein 3 gene is governed by a complex interplay between the promoter and intronic sequences Diabetologia  2009 52:1638-1646  DOI:10.1007/s00125-009-1385-9  PMID:19468707
  • Bornes, S., Prado-Lourenco, L., Bastide, A., Zanibellato, C., Iacovoni, J. S., Lacazette, E., Prats, A. C., Touriol, C., Prats, H. Translational induction of VEGF internal ribosome entry site elements during the early response to ischemic stress Circulation Research  2007 100:305-308  DOI:10.1161/01.RES.0000258873.08041.c9  PMID:17255526
  • Bornes, S., Boulard, M., Hieblot, C., Zanibellato, C., Iacovoni, J. S., Prats, H., Touriol, C. Control of the vascular endothelial growth factor internal ribosome entry site (IRES) activity and translation initiation by alternatively spliced coding sequences Journal of Biological Chemistry  2004 279:18717-18726  DOI:10.1074/jbc.M308410200
  • Stevens, T. A., Iacovoni, J. S., Edelman, D. B., Meech, R. Identification of novel binding elements and gene targets for the homeodomain protein BARX2 Journal of Biological Chemistry  2004 279:14520-14530  DOI:10.1074/jbc.M310259200  PMID:14744868
  • Iacovoni, J. S., Cohen, S. B., Berg, T., Vogt, P. K. V-jun targets showing an expression pattern that correlates with the transformed cellular phenotype Oncogene  2004 23:5703-5706  DOI:10.1038/sj.onc.1207737  PMID:15133497
  • Iacovoni, J. S. GeneHuggers: database mining and application connectivity tools for subsequence analyses of the human genome Bioinformatics  2003 19:2316-2318  DOI:10.1093/bioinformatics/btg304  PMID:14630663
  • Iacovoni, J. S., Russell, P., Gaits, F. A new inducible protein expression system in fission yeast based on the glucose-repressed inv1 promoter Gene  1999 232:53-58  DOI:10.1016/s0378-1119(99)00116-x  PMID:10333521
  • Vogt, P. K., Aoki, M., Bottoli, I., Chang, H. W., Fu, S. L., Hecht, A., Iacovoni, J. S., Jiang, B. H., Kruse, U. A random walk in oncogene space: The quest for targets Cell Growth & Differentiation  1999 10:777-784  PMID:10616902
  • Goller, M. E., Iacovoni, J. S., Vogt, P. K., Kruse, U. Glutaredoxin is a direct target of oncogenic jun Oncogene  1998 16:2945-2948  DOI:10.1038/sj.onc.1201819  PMID:9671415
  • Himly, M., Foster, D. N., Bottoli, I., Iacovoni, J. S., Vogt, P. K. The df-1 chicken fibroblast cell line: Transformation induced by diverse oncogenes and cell death resulting from infection by avian leukosis viruses Virology  1998 248:295-304  DOI:10.1006/viro.1998.9290  PMID:9721238
  • Freyaldenhoven, B. S., Freyaldenhoven, M. P., Iacovoni, J. S., Vogt, P. K. Aberrant cell growth induced by avian winged helix proteins Cancer Research  1997 57:123-129  PMID:8988052
  • Freyaldenhoven, B. S., Freyaldenhoven, M. P., Iacovoni, J. S., Vogt, P. K. Avian winged helix proteins CWH-1, CWH-2 and CWH-3 repress transcription from Qin binding sites Oncogene  1997 15:483-488  DOI:10.1038/sj.onc.1201189  PMID:9242385
  • Kruse, U., Iacovoni, J. S., Goller, M. E., Vogt, P. K. Hormone-regulatable neoplastic transformation induced by a Jun-estrogen receptor chimera Proceedings of the National Academy of Sciences of the United States of America  1997 94:12396-12400  DOI:10.1073/pnas.94.23.12396  PMID:9356460
  • Li, J., Thurm, H., Chang, H. W., Iacovoni, J. S., Vogt, P. K. Oncogenic transformation induced by the Qin protein is correlated with transcriptional repression Proceedings of the National Academy of Sciences of the United States of America  1997 94:10885-10888  DOI:10.1073/pnas.94.20.10885  PMID:9380729
  • Schuur, E. R., Kruse, U., Iacovoni, J. S., Vogt, P. K. Nuclear factor I interferes with transformation induced by nuclear oncogenes Cell Growth & Differentiation  1995 6:219-227  PMID:7794790

Background

education and training

• Ph.D. in Biology, Scripps Research 1993 - 2003
• B.A. in Biology, University of California, San Diego 1993

advisee of

• graduate advising relationship

  • Vogt, Peter K., Ph.D.  candidacy, 1994 - 2003

Contact

full name

• Jason Scott Iacovoni

geographic location

• Scripps California