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Hof, Fraser
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Hof, Fraser

Graduate Student
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Positions

  • 2011 - Faculty Member, University of Victoria

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Publications

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  • academic article

    • Beatty, M. A., Busmann, J. A., Fagen, N. G., Garnett, G. A. E., Hof, F. A clip-like host that undergoes self-assembly and competitive guest-induced disassembly in water Supramolecular Chemistry  2019 31:101-107  DOI:10.1080/10610278.2018.1494275
    • Beatty, M. A., Pye, A. T., Shaurya, A., Kim, B., Selinger, A. J., Hof, F. Using reversible non-covalent and covalent bonds to create assemblies and equilibrating molecular networks that survive 5 molar urea Organic & Biomolecular Chemistry  2019 17:2081-2086  DOI:10.1039/c8ob02909a  PMID:30698579
    • Beatty, M. A., Borges-Gonzalez, J., Sinclair, N. J., Pye, A. T., Hof, F. Analyte-driven disassembly and turn-on fluorescent sensing in competitive biological media Journal of the American Chemical Society  2018 140:3500-3504  DOI:10.1021/jacs.7b13298  PMID:29461821
    • Denton, K. E., Wang, S., Gignac, M. C., Milosevich, N., Hof, F., Dykhuizen, E. C., Krusemark, C. J. Robustness of in vitro selection assays of DNA-encoded peptidomimetic ligands to CBX7 and CBX8 SLAS Discovery  2018 23:417-428  DOI:10.1177/2472555217750871  PMID:29309209  PMCID:PMC5962403
    • Traore, M., Gignac, M., Doan, N. D., Hof, F., Lubell, W. D. Aza-amino acid scanning of chromobox homolog 7 (CBX7) ligands Journal of Peptide Science  2017 23:266-271  DOI:10.1002/psc.2982  PMID:28220557
    • Li, W., Kuehne, N. W., Dallin, E., Gordon, R., Hof, F. A supramolecular indicator displacement assay for acetyl amantadine, a proxy biomarker for spermidine/spermine N-1-acetyltransferase (SSAT) activity Canadian Journal of Chemistry  2016 94:969-975  DOI:10.1139/cjc-2016-0411
    • Garnett, G. A. E., Daze, K. D., Diaz, J. A. P., Fagen, N., Shaurya, A., Ma, M. C. F., Collins, M. S., Johnson, D. W., Zakharov, L. N., Hof, F. Attraction by repulsion: compounds with like charges undergo self-assembly in water that improves in high salt and persists in real biological fluids Chemical Communications  2016 52:2768-2771  DOI:10.1039/c5cc10527g
    • Milosevich, N., Hof, F. Chemical inhibitors of epigenetic methyllysine reader proteins Biochemistry  2016 55:1570-1583  DOI:10.1021/acs.biochem.5b01073  PMID:26650180
    • Hof, F. Host-guest chemistry that directly targets lysine methylation: synthetic host molecules as alternatives to bio-reagents Chemical Communications  2016 52:10093-10108  DOI:10.1039/c6cc04771h  PMID:27374270
    • Hobbs, J. K., Lee, S. M., Robb, M., Hof, F., Barr, C., Abe, K. T., Hehemann, J. H., McLean, R., Abbott, D. W., Boraston, A. B. KdgF, the missing link in the microbial metabolism of uronate sugars from pectin and alginate Proceedings of the National Academy of Sciences of the United States of America  2016 113:6188-6193  DOI:10.1073/pnas.1524214113  PMID:27185956  PMCID:PMC4896693
    • Hanley, R. P., Horvath, S., An, J., Hof, F., Wulff, J. E. Salicylates are interference compounds in TR-FRET assays Bioorganic & Medicinal Chemistry Letters  2016 26:973-977  DOI:10.1016/j.bmcl.2015.12.050  PMID:26733476
    • Milosevich, N., Gignac, M. C., McFarlane, J., Simhadri, C., Horvath, S., Daze, K. D., Croft, C. S., Dheri, A., Quon, T. T. H., Douglas, S. F., Wulff, J. E., Paci, I., et al. Selective inhibition of CBX6: a methyllysine reader protein in the polycomb family ACS Medicinal Chemistry Letters  2016 7:139-144  DOI:10.1021/acsmedchemlett.5b00378
    • Milosevich, N., Warmerdam, Z., Hof, F. Structural aspects of small-molecule inhibition of methyllysine reader proteins Future Medicinal Chemistry  2016 8:1681-1702  DOI:10.4155/fmc-2016-0082  PMID:27577975
    • Simhadri, C., Gignac, M. C., Anderson, C. J., Milosevich, N., Dheri, A., Prashar, N., Flemmer, R. T., Dev, A., Henderson, T. G., Douglas, S. F., Wulff, J. E., Hof, F. Structure–activity relationships of Cbx7 inhibitors, including selectivity studies against other Cbx proteins ACS Omega  2016 1:541-551  DOI:10.1021/acsomega.6b00120
    • Garnett, G. A. E., Starke, M. J., Shaurya, A., Li, J., Hof, F. Supramolecular affinity chromatography for methylation-targeted proteomics Analytical Chemistry  2016 88:3697-3703  DOI:10.1021/acs.analchem.5b04508
    • Ali, M., Daze, K. D., Strongin, D. E., Rothbart, S. B., Rincon-Arano, H., Allen, H. F., Li, J., Strahl, B. D., Hof, F., Kutateladze, T. G. Molecular Insights into Inhibition of the Methylated Histone-Plant Homeodomain Complexes by Calixarenes Journal of Biological Chemistry  2015 290:22919-22930  DOI:10.1074/jbc.M115.669333  PMID:26229108  PMCID:PMC4645621
    • McGovern, R. E., Snarr, B. D., Lyons, J. A., McFarlane, J., Whiting, A. L., Paci, I., Hof, F., Crowley, P. B. Structural study of a small molecule receptor bound to dimethyllysine in lysozyme Chemical Science  2015 6:442-449  DOI:10.1039/c4sc02383h  PMID:25530835  PMCID:PMC4266562
    • Shaurya, A., Dubicki, K. I., Hof, F. Chemical agents for binding post-translationally methylated lysines and arginines Supramolecular Chemistry  2014 26:583-590  DOI:10.1080/10610278.2013.872786
    • Simhadri, C., Daze, K. D., Douglas, S. F., Quon, T. T. H., Dev, A., Gignac, M. C., Peng, F., Heller, M., Boulanger, M. J., Wulff, J. E., Hof, F. Chromodomain antagonists that target the polycomb-group methyllysine reader protein chromobox homolog 7 (CBX7) Journal of Medicinal Chemistry  2014 57:2874-2883  DOI:10.1021/jm401487x  PMID:24625057
    • Allen, H. F., Daze, K. D., Shimbo, T., Lai, A., Musselman, C. A., Sims, J. K., Wade, P. A., Hof, F., Kutateladze, T. G. Inhibition of histone binding by supramolecular hosts Biochemical Journal  2014 459:505-512  DOI:10.1042/bj20140145  PMID:24576085  PMCID:PMC4454452
    • Wang, X., Post, J., Hore, D. K., Hof, F. Minimalist synthetic host with stacked guanidinium ions mimics the weakened hydration shells of protein-protein interaction interfaces Journal of Organic Chemistry  2014 79:34-40  DOI:10.1021/jo401949s  PMID:24328280
    • Cao, G., Hajisalem, G., Li, W., Hof, F., Gordon, R. Quantification of an exogenous cancer biomarker in urinalysis by Raman Spectroscopy Analyst  2014 139:5375-5378  DOI:10.1039/c4an01309c  PMID:25181750
    • Wu, J., Li, W., Hajisalem, G., Lukach, A., Kumacheva, E., Hof, F., Gordon, R. Trace cancer biomarker quantification using polystyrene-functionalized gold nanorods Biomedical Optics Express  2014 5:4101-4107  DOI:10.1364/boe.5.004101  PMID:25574423  PMCID:PMC4285590
    • Daze, K. D., Jones, C. E., Lilgert, B. J., Beshara, C. S., Hof, F. Determining the effects of salt, buffer, and temperature on the complexation of methylated ammonium ions and methyllysines by sulfonated calixarenes Canadian Journal of Chemistry-Revue Canadienne De Chimie  2013 91:1072-1076  DOI:10.1139/cjc-2013-0186
    • Pinter, T., Simhadri, C., Hof, F. Dissecting the complex recognition interfaces of potent tetrazole- and pyrrole-based anion binders Journal of Organic Chemistry  2013 78:4642-4648  DOI:10.1021/jo400372c  PMID:23631741
    • Whiting, A. L., Dubicki, K. I., Hof, F. Synthesis of versatile nonsymmetric amine- and boron-functionalized Tröger's base derivatives, including a Tröger's base amino acid European Journal of Organic Chemistry  2013 2013:6802-6810  DOI:10.1002/ejoc.201300992
    • Tabet, S., Douglas, S. F., Daze, K. D., Garnett, G. A. E., Allen, K. J. H., Abrioux, E. M. M., Quon, T. T. H., Wulff, J. E., Hof, F. Synthetic trimethyllysine receptors that bind histone 3, trimethyllysine 27 (H3K27me3) and disrupt its interaction with the epigenetic reader protein CBX7 Bioorganic & Medicinal Chemistry  2013 21:7004-7010  DOI:10.1016/j.bmc.2013.09.024  PMID:24100156
    • Daze, K. D., Hof, F. The cation-pi interaction at protein-protein interaction interfaces: developing and learning from synthetic mimics of proteins that bind methylated lysines Accounts of Chemical Research  2013 46:937-945  DOI:10.1021/ar300072g  PMID:22724379
    • Wang, X., Hof, F. (How) does 1,3,5-triethylbenzene scaffolding work? Analyzing the abilities of 1,3,5-triethylbenzene- and 1,3,5-trimethylbenzene-based scaffolds to preorganize the binding elements of supramolecular hosts and to improve binding of targets Beilstein Journal of Organic Chemistry  2012 8:1-10  DOI:10.3762/bjoc.8.1  PMID:22423267  PMCID:PMC3302067
    • Jana, S., Whiting, A. L., Hazra, A., Sen, S., Goswami, S., Mehta, G., Fun, H. K., Hof, F. Anion recognition by a family of quinoline-functionalised bis-amide hosts in solid state and in solution Supramolecular Chemistry  2012 24:385-391  DOI:10.1080/10610278.2012.676179
    • Minaker, S. A., Daze, K. D., Ma, M. C. F., Hof, F. Antibody-free reading of the histone code using a simple chemical sensor array Journal of the American Chemical Society  2012 134:11674-11680  DOI:10.1021/ja303465x  PMID:22703116
    • Whiting, A. L., Hof, F. Binding trimethyllysine and other cationic guests in water with a series of indole-derived hosts: large differences in affinity from subtle changes in structure Organic & Biomolecular Chemistry  2012 10:6885-6892  DOI:10.1039/c2ob25882j  PMID:22828995
    • Murray, J. I., Tonkin, M. L., Whiting, A. L., Peng, F. N., Farnell, B., Cullen, J. T., Hof, F., Boulanger, M. J. Structural characterization of S100A15 reveals a novel zinc coordination site among S100 proteins and altered surface chemistry with functional implications for receptor binding BMC Structural Biology  2012 12  DOI:10.1186/1472-6807-12-16  PMID:22747601  PMCID:PMC3434032
    • Daze, K. D., Pinter, T., Beshara, C. S., Ibraheem, A., Minaker, S. A., Ma, M. C. F., Courtemanche, R. J. M., Campbell, R. E., Hof, F. Supramolecular hosts that recognize methyllysines and disrupt the interaction between a modified histone tail and its epigenetic reader protein Chemical Science  2012 3:2695-2699  DOI:10.1039/c2sc20583a
    • Daze, K. D., Ma, M. C. F., Pineux, F., Hof, F. Synthesis of new trisulfonated calix[4]arenes functionalized at the upper rim, and their complexation with the trimethyllysine epigenetic mark Organic Letters  2012 14:1512-1515  DOI:10.1021/ol300243b  PMID:22397706
    • Pape, J., McQuinn, K., Hof, F., McIndoe, J. S. Blurring the line between solution and the gas phase: collision-induced dissociation of hypersolvated lanthanide trications provides insights into solution acidity New Journal of Chemistry  2011 35:1582-1587  DOI:10.1039/c1nj20105k
    • Courtemanche, R. J. M., Pinter, T., Hof, F. Just add tetrazole: 5-(2-pyrrolo)tetrazoles are simple, highly potent anion recognition elements Chemical Communications  2011 47:12688-12690  DOI:10.1039/c1cc15875a  PMID:22038194
    • Pinter, T., Jana, S., Courtemanche, R. J. M., Hof, F. Recognition properties of carboxylic acid bioisosteres: anion binding by tetrazoles, aryl sulfonamides, and acyl sulfonamides on a calix[4]arene scaffold Journal of Organic Chemistry  2011 76:3733-3741  DOI:10.1021/jo200031u  PMID:21462934
    • Beshara, C. S., Jones, C. E., Daze, K. D., Lilgert, B. J., Hof, F. A simple calixarene recognizes post-translationally methylated lysine ChemBioChem  2010 11:63-66  DOI:10.1002/cbic.200900633  PMID:19937593
    • Khan, M. A., Moktar, J., Mott, P. J., Vu, M., McKie, A. H., Pinter, T., Hof, F., Bishop, R. E. Inscribing the perimeter of the PagP hydrocarbon ruler by site-specific chemical alkylation Biochemistry  2010 49:9046-9057  DOI:10.1021/bi1011496  PMID:20853818  PMCID:PMC5007119
    • Beshara, C. S., Hof, F. Modular incorporation of 1-benzyltryptophan into dipeptide hosts that bind acetylcholine in pure water Canadian Journal of Chemistry-Revue Canadienne De Chimie  2010 88:1009-1016  DOI:10.1139/v10-100
    • Whiting, A. L., Neufeld, N. M., Hof, F. A tryptophan-analog host whose interactions with ammonium ions in water are dominated by the hydrophobic effect Tetrahedron Letters  2009 50:7035-7037  DOI:10.1016/j.tetlet.2009.09.161
    • McQuinn, K., Hof, F., McIndoe, J. S. Collision-induced dissociation of protonated nanodroplets International Journal of Mass Spectrometry  2009 279:32-36  DOI:10.1016/j.ijms.2008.10.001
    • McQuinn, K., Hof, F., McIndoe, J. S., Chen, X., Wu, G., Stace, A. J. Evidence of asymmetric cation solvation from the instability of Pb(H2O)(n) (2+) complexes Chemical Communications  2009 4088-4090  DOI:10.1039/b901368g
    • Leon, R., Murray, J. I., Cragg, G., Farnell, B., West, N. R., Pace, T. C. S., Watson, P. H., Bohne, C., Boulanger, M. J., Hof, F. Identification and characterization of binding sites on S100A7, a participant in cancer and inflammation pathways Biochemistry  2009 48:10591-10600  DOI:10.1021/bi901330g  PMID:19810752
    • West, N. R., Farnell, B., Murray, J. I., Hof, F., Watson, P. H., Boulanger, M. J. Structural and functional characterization of a triple mutant form of S100A7 defective for Jab1 binding Protein Science  2009 18:2615-2623  DOI:10.1002/pro.274  PMID:19844956  PMCID:PMC2821279
    • Zurcher, M., Hof, F., Barandun, L., Schutz, A., Schweizer, W. B., Meyer, S., Bur, D., Diederich, F. Synthesis of exo-3-amino-7-azabicyclo 2.2.1 heptanes as a class of malarial aspartic protease inhibitors: exploration of two binding pockets European Journal of Organic Chemistry  2009 1707-1719  DOI:10.1002/ejoc.200801184
    • Wang, X., Sarycheva, G., Koivisto, B. D., McKie, A. H., Hof, F. A terphenyl scaffold for pi-stacked guanidinium recognition elements Organic Letters  2008 10:297-300  DOI:10.1021/ol7027042  PMID:18092794
    • McQuinn, K., McIndoe, L. S., Hof, F. Insights into the post-translational methylation of arginine from studies of guanidinium-water nanodroplets Chemistry-A European Journal  2008 14:6483-6489  DOI:10.1002/chem.200800101  PMID:18546445
    • McKie, A. H., Friedland, S., Hof, F. Tetrazoles are potent anion recognition elements that emulate the disfavored anti conformations of carboxylic acids Organic Letters  2008 10:4653-4655  DOI:10.1021/ol801943u  PMID:18816055
    • Mahnke, D. J., McDonald, R., Hof, F. A shape-dependent hydrophobic effect for tetrazoles Chemical Communications  2007 3738-3740  DOI:10.1039/b705256a  PMID:17851612
    • McQuinn, K., Hof, F., McIndoe, J. S. Direct observation of ion evaporation from a triply charged nanodroplet Chemical Communications  2007 4099-4101  DOI:10.1039/b711689f  PMID:17925941
    • Berryman, O. B., Hof, F., Hynes, M. J., Johnson, D. W. Anion-pi interaction augments halide binding in solution Chemical Communications  2006 506-508  DOI:10.1039/b511570a  PMID:16432564
    • Hof, F., Schutz, A., Fah, C., Meyer, S., Bur, D., Liu, J., Goldberg, D. E., Diederich, F. Starving the malaria parasite: Inhibitors active against the aspartic proteases plasmepsins I, II, and IV Angewandte Chemie - International Edition  2006 45:2138-2141  DOI:10.1002/anie.200504119  PMID:16502446
    • Hof, F., Schar, M., Scofield, D. M., Fischer, F., Diederich, F., Sergeyev, S. Preparation of Tröger base derivatives by cross-coupling methodologies Helvetica Chimica Acta  2005 88:2333-2344  DOI:10.1002/hlca.200590168
    • Hof, F., Scofield, D. M., Schweizer, W. B., Diederich, F. A weak attractive interaction between organic fluorine and an amide group Angewandte Chemie - International Edition  2004 43:5056-5059  DOI:10.1002/anie.200460781  PMID:15384111
    • Hof, F., Diederich, F. Medicinal chemistry in academia: molecular recognition with biological receptors Chemical Communications  2004 477-480  DOI:10.1039/b314081b  PMID:14973570
    • degree-related publication Biros, S. M., Ullrich, E. C., Hof, F., Trembleau, L., Rebek, J. Kinetically stable complexes in water: The role of hydration and hydrophobicity Journal of the American Chemical Society  2004 126:2870-2876  DOI:10.1021/ja038823m  PMID:14995204
    • degree-related publication Hof, F., Trembleau, L., Ullrich, E. C., Rebek, J. Acetylcholine recognition by a deep, biomimetic pocket Angewandte Chemie-International Edition  2003 42:3150-3153  DOI:10.1002/anie.2003451174  PMID:12866104
    • degree-related publication Johnson, D. W., Hof, F., Palmer, L. C., Martin, T., Obst, U., Rebek Jr., J. Glycoluril ribbons tethered by complementary hydrogen bonds Chemical Communications  2003 1638-1639  DOI:10.1039/b303508e  PMID:12877479
    • degree-related publication Hof, F., Craig, S. L., Nuckolls, C., Rebek, J. Molecular encapsulation Angewandte Chemie-International Edition  2002 41:1488-1508  DOI:10.1002/1521-3773(20020503)41:9<1488::aid-anie1488>3.0.co;2-g  PMID:19750648
    • degree-related publication Hof, F., Rebek, J. Molecules within molecules: Recognition through self-assembly Proceedings of the National Academy of Sciences of the United States of America  2002 99:4775-4777  DOI:10.1073/pnas.042663699  PMID:11880604  PMCID:PMC122666
    • degree-related publication Johnson, D. W., Palmer, L. C., Hof, F., Iovine, P. M., Rebek Jr., J. New supramolecular organization for a glycoluril: Chiral hydrogen-bonded ribbons Chemical Communications  2002 2228-2229  DOI:10.1039/b206648c  PMID:12397991
    • degree-related publication Johnson, D. W., Hof, F., Iovine, P. M., Nuckolls, C., Rebek, J. Solid-state and solution studies of a tetrameric capsule and its guests Angewandte Chemie-International Edition  2002 41:3793-3796  DOI:10.1002/1521-3773(20021018)41:20<3793::aid-anie3793>3.0.co;2-a  PMID:12386850
    • degree-related publication Hof, F., Iovine, P. M., Johnson, D. W., Rebek, J. Highly selective synthesis of heterosubstituted aromatic sulfamides Organic Letters  2001 3:4247-4249  DOI:10.1021/ol0169731  PMID:11784189
    • degree-related publication Hof, F., Palmer, L. C., Rebek Jr., J. Synthesis and self-assembly of the "tennis ball" dimer and subsequent encapsulation of methane: an advanced organic chemistry laboratory experiment Journal of Chemical Education  2001 78:1519-1521  DOI:10.1021/ed078p1519
    • degree-related publication Hof, F., Nuckolls, C., Rebek, J. Diversity and selection in self-assembled tetrameric capsules Journal of the American Chemical Society  2000 122:4251-4252  DOI:10.1021/ja0005136
    • degree-related publication Hof, F., Nuckolls, C., Craig, S. L., Martin, T., Rebek, J. Emergent conformational preferences of a self-assembling small molecule: Structure and dynamics in a tetrameric capsule Journal of the American Chemical Society  2000 122:10991-10996  DOI:10.1021/ja002340q
    • Pelisson, M. M. M., da Silva, G. V. J., Clive, D. L. J., Coltart, D. M., Hof, F. A. Studies on the preparation of 3,4-disubstituted 2-methoxypyridines Journal of Heterocyclic Chemistry  1999 36:653-658
    • degree-related publication Nuckolls, C., Hof, F., Martin, T., Rebek, J. Chiral microenvironments in self-assembled capsules Journal of the American Chemical Society  1999 121:10281-10285  DOI:10.1021/ja992779m
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Background

education and training

  • Ph.D. in Chemistry, Scripps Research 1998 - 2003
  • B.Sc. in Chemistry, University of Alberta 1993 - 1998

advisee of

  • graduate advising relationship

    • Rebek Jr., Julius, Ph.D.  candidacy, 1999 - 2003
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Contact

full name

  • Fraser Alan Hof

geographic location

  • Scripps California 

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