Hodder, Peter

Faculty Member

Positions

2007 - 2013 Associate Professor of Molecular Therapeutics (Joint Appointment), Molecular Therapeutics , Scripps Research
2005 - 2013 Adjunct Professor of Electrical Engineering & Bioengineering, Department of Electrical Engineering, Florida Atlantic University
2005 - 2013 Senior Scientific Director, Translational Research Institute , Scripps Research
2005 - 2013 Director, Lead Identification, Translational Research Institute , Scripps Research
2005 - 2012 Director, Molecular Screening Center , Scripps Research
2003 - 2005 Research Fellow, Department of Automated Biotechnology, Merck Research Laboratories, Merck & Co., Inc.
1999 - 2003 Senior Research Biochemist, Department of Automated Biotechnology, Merck Research Laboratories, Merck & Co., Inc.

Research Areas

Hepatitis C (UMLS)

Publications
Affiliation
Research
Background
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recent publications

academic article
- Spicer, T. P., Gardiner, D. L., Schoenen, F. J., Roy, S., Griffin, P. R., Chase, P., Scampavia, L., Hodder, P., Trenholme, K. R. Identification of antimalarial inhibitors using late-stage gametocytes in a phenotypic live/dead sssay SLAS Discovery 2019 24:38-46 DOI:10.1177/2472555218796410 PMID:30142014
- Nieto, A., Fernandez-Vega, V., Spicer, T. P., Sturchler, E., Adhikari, P., Kennedy, N., Mandat, S., Chase, P., Scampavia, L., Bannister, T., Hodder, P., McDonald, P. H. Identification of Novel, Structurally Diverse, Small Molecule Modulators of GPR119 Assay and Drug Development Technologies 2018 16:278-288 DOI:10.1089/adt.2018.849 PMID:30019946 PMCID:PMC6065524
- Swingle, M., Volmar, C. H., Saldanha, S. A., Chase, P., Eberhart, C., Salter, E. A., D'Arcy, B., Schroeder, C. E., Golden, J. E., Wierzbicki, A., Hodder, P., Honkanen, R. E. An ultra-high-throughput screen for catalytic inhibitors of serine/threonine protein phosphatases types 1 and 5 (PP1C and PP5C) SLAS Discovery 2017 22:21-31 DOI:10.1177/1087057116668852 PMID:27628691
- Wang, J., Fang, P. F., Chase, P., Tshori, S., Razin, E., Spicer, T. P., Scampavia, L., Hodder, P., Guo, M. Development of an HTS-compatible assay for discovery of melanoma-related microphthalmia transcription factor disruptors using AlphaScreen technology SLAS Discovery 2017 22:58-66 DOI:10.1177/1087057116675274 PMID:27827304
- Ewing, H., Fernandez-Vega, V., Spicer, T. P., Chase, P., Brown, S., Scampavia, L., Roush, W. R., Riley, S., Rosen, H., Hodder, P., Lambeau, G., Gelb, M. H. Fluorometric high-throughput screening assay for secreted phospholipases A(2) using phospholipid vesicles Journal of Biomolecular Screening 2016 21:713-721 DOI:10.1177/1087057116646742 PMID:27146384
- Plate, L., Cooley, C. B., Chen, J. J., Paxman, R. J., Gallagher, C. M., Madoux, F., Genereux, J. C., Dobbs, W., Garza, D., Spicer, T. P., Scampavia, L., Brown, S. J., et al. Small molecule proteostasis regulators that reprogram the ER to reduce extracellular protein aggregation ELife 2016 5 DOI:10.7554/eLife.15550 PMID:27435961 PMCID:PMC4954754
- Schreiber, S. L., Kotz, J. D., Li, M., Aube, J., Austin, C. P., Reed, J. C., Rosen, H., White, E. L., Sklar, L. A., Lindsley, C. W., Alexander, B. R., Bittker, J. A., et al. Advancing biological understanding and therapeutics discovery with small-molecule probes Cell 2015 161:1252-1265 DOI:10.1016/j.cell.2015.05.023 PMID:26046436 PMCID:PMC4564295
- Smith, E., Chase, P., Niswender, C. M., Utley, T. J., Sheffler, D. J., Noetzel, M. J., Lamsal, A., Wood, M. R., Conn, P. J., Lindsley, C. W., Madoux, F., Acosta, M., et al. Application of parallel multiparametric cell-based FLIPR detection assays for the identification of modulators of the muscarinic acetylcholine receptor 4 (M-4) Journal of Biomolecular Screening 2015 20:858-868 DOI:10.1177/1087057115581770 PMID:25877150 PMCID:PMC4659430
- Han, C., Chatterjee, A., Noetzel, M. J., Panarese, J. D., Smith, E., Chase, P., Hodder, P., Niswender, C., Conn, P. J., Lindsley, C. W., Stauffer, S. R. Discovery and SAR of muscarinic receptor subtype 1 (M-1) allosteric activators from a molecular libraries high throughput screen. Part 1: 2,5-Dibenzyl-2H-pyrazolo 4,3-c quinolin-3(5H)-ones as positive allosteric modulators Bioorganic & Medicinal Chemistry Letters 2015 25:384-388 DOI:10.1016/j.bmcl.2014.11.011 PMID:25435150 PMCID:PMC4278958
- Sanders, M. A., Madoux, F., Mladenovic, L., Zhang, H., Ye, X., Angrish, M., Mottillo, E. P., Caruso, J. A., Halvorsen, G., Roush, W. R., Chase, P., Hodder, P., et al. Endogenous and synthetic ABHD5 ligands regulate ABHD5-perilipin interactions and lipolysis in fat and muscle Cell Metabolism 2015 22:851-860 DOI:10.1016/j.cmet.2015.08.023 PMID:26411340 PMCID:PMC4862007
- Wang, Y., Stowe, R. L., Pinello, C. E., Tian, G., Madoux, F., Li, D., Zhao, L. Y., Li, J. L., Wang, Y., Wang, Y., Ma, H., Hodder, P., et al. Identification of histone deacetylase inhibitors with benzoylhydrazide scaffold that selectively inhibit class I histone deacetylases Chemistry & Biology 2015 22:273-284 DOI:10.1016/j.chembiol.2014.12.015 PMID:25699604 PMCID:PMC4365786
- Pedro-Rosa, L., Buckner, F. S., Ranade, R. M., Eberhart, C., Madoux, F., Gillespie, J. R., Koh, C. Y., Brown, S., Lohse, J., Verlinde, C. L. M., Fan, E., Bannister, T., et al. Identification of potent inhibitors of the Trypanosoma brucei methionyl-tRNA synthetase via high-throughput orthogonal screening Journal of Biomolecular Screening 2015 20:122-130 DOI:10.1177/1087057114548832 PMID:25163684 PMCID:PMC4378865
- Ting, P. Y., Damoiseaux, R., Titz, B., Bradley, K. A., Graeber, T. G., Fernandez-Vega, V., Bannister, T. D., Chase, P., Nair, R., Scampavia, L., Hodder, P., Spicer, T. P., et al. Identification of small molecules that disrupt signaling between ABL and its positive regulator RIN1 PLoS One 2015 10:e0121833 DOI:10.1371/journal.pone.0121833 PMID:25811598 PMCID:PMC4374917
- Chang, J. W., Zuhl, A. M., Speers, A. E., Niessen, S., Brown, S. J., Mulvihill, M. M., Fan, Y. C., Spicer, T. P., Southern, M., Scampavia, L., Fernandez-Vega, V., Dix, M. M., et al. Selective inhibitor of platelet-activating factor acetylhydrolases 1b2 and 1b3 that impairs cancer cell survival ACS Chemical Biology 2015 10:925-932 DOI:10.1021/cb500893q PMID:25602368 PMCID:PMC4402257
- Abdul-Hay, S. O., Bannister, T. D., Wang, H., Cameron, M. D., Caulfield, T. R., Masson, A., Bertrand, J., Howard, E. A., McGuire, M. P., Crisafulli, U., Rosenberry, T. R., Topper, C. L., et al. Selective targeting of extracellular insulin-degrading enzyme by quasi-irreversible thiol-modifying inhibitors ACS Chemical Biology 2015 10:2716-2724 DOI:10.1021/acs.chembio.5b00334 PMID:26398879
- Zhao, N., Darby, C. M., Small, J., Bachovchin, D. A., Jiang, X., Burns-Huang, K. E., Botella, H., Ehrt, S., Boger, D. L., Anderson, E. D., Cravatt, B. F., Speers, A. E., et al. Target-based screen against a periplasmic serine protease that regulates intrabacterial pH homeostasis in Mycobacterium tuberculosis ACS Chemical Biology 2015 10:364-371 DOI:10.1021/cb500746z PMID:25457457 PMCID:PMC4340348
- Spicer, T., Fernandez-Vega, V., Chase, P., Scampavia, L., To, J., Dalton, J. P., Da Silva, F. L., Skinner-Adams, T. S., Gardiner, D. L., Trenholme, K. R., Brown, C. L., Ghosh, P., et al. Identification of potent and selective inhibitors of the plasmodium falciparum M18 aspartyl aminopeptidase (PfM18AAP) of human malaria via high-throughput screening Journal of Biomolecular Screening 2014 19:1107-1115 DOI:10.1177/1087057114525852 PMID:24619116 PMCID:PMC4641816
- Lewallen, D. M., Bicker, K. L., Madoux, F., Chase, P., Anguish, L., Coonrod, S., Hodder, P., Thompson, P. R. A FluoPol-ABPP PAD2 high-throughput screen identifies the first calcium site inhibitor targeting the PADs ACS Chemical Biology 2014 9:913-921 DOI:10.1021/cb400841k PMID:24467619 PMCID:PMC4108211
- Wang, Y., Lonard, D. M., Yu, Y., Chow, D. C., Palzkill, T. G., Wang, J., Qi, R., Matzuk, A. J., Song, X., Madoux, F., Hodder, P., Chase, P., et al. Bufalin is a potent small-molecule inhibitor of the steroid receptor coactivators SRC-3 and SRC-1 Cancer Research 2014 74:1506-1517 DOI:10.1158/0008-5472.can-13-2939 PMID:24390736 PMCID:PMC3947477
- Penas, C., Ramachandran, V., Simanski, S., Lee, C., Madoux, F., Rahaim, R. J., Chauhan, R., Barnaby, O., Schurer, S., Hodder, P., Steen, J., Roush, W. R., et al. Casein kinase 1 delta-dependent Wee1 protein degradation Journal of Biological Chemistry 2014 289:18893-18903 DOI:10.1074/jbc.M114.547661 PMID:24817118 PMCID:PMC4081930
- Jiang, J., Taylor, A. B., Choi, J. Y., Hart, P. J., Roush, W. R., Fields, G. B., Hodder, P. S., Minong, D., Spicer, T. P. Characterization of selective exosite-binding inhibitors of matrix metalloproteinase 13 that prevent articular cartilage degradation in vitro Journal of Medicinal Chemistry 2014 57:9598-9611 DOI:10.1021/jm501284e PMID:25330343 PMCID:PMC4255739
- Gentry, P. R., Kokubo, M., Bridges, T. M., Noetzel, M. J., Cho, H. P., Lamsal, A., Smith, E., Chase, P., Hodder, P. S., Niswender, C. M., Daniels, J. S., Conn, P. J., et al. Development of a highly potent, novel M(5) positive allosteric modulator (PAM) demonstrating CNS exposure: 1-((1H-indazol-5-yl)sulfoneyl)-N-ethyl-N-(2-(trifluoromethyl)benzyl)pipe ridine-4-carboxamide (ML380) Journal of Medicinal Chemistry 2014 57:7804-7810 DOI:10.1021/jm500995y PMID:25147929 PMCID:PMC4175000
- Sturchler, E., Chen, W., Spicer, T., Hodder, P., McDonald, P., Duckett, D. Development of an HTS-compatible assay for the discovery of ASK1 signalosome inhibitors using alphascreen technology Assay and Drug Development Technologies 2014 12:229-237 DOI:10.1089/adt.2013.558 PMID:24831789 PMCID:PMC4025566
- Madoux, F., Tredup, C., Scampavia, L., Chase, P. S., Hodder, P. S., Fields, G. B., Becker-Pauly, C., Minond, D., Spicer, T. P. Development of high throughput screening assays and pilot screen for inhibitors of metalloproteases meprin α and β Biopolymers 2014 102:396-406 DOI:10.1002/bip.22527 PMID:25048711 PMCID:PMC4339026
- Gentry, P. R., Kokubo, M., Bridges, T. M., Cho, H. P., Smith, E., Chase, P., Hodder, P. S., Utley, T. J., Rajapakse, A., Byers, F., Niswender, C. M., Morrison, R. D., et al. Discovery, synthesis and characterization of a highly muscarinic acetylcholine receptor (mAChR)-selective M5-orthosteric antagonist, VU0488130 (ML381): a novel molecular probe ChemMedChem 2014 9:1677-1682 DOI:10.1002/cmdc.201402051 PMID:24692176 PMCID:PMC4116439
- Kadakkuzha, B. M., Spicer, T. P., Chase, P., Richman, J. B., Hodder, P., Puthanveettil, S. V. High-throughput screening for small molecule modulators of motor protein Kinesin Assay and Drug Development Technologies 2014 12:470-480 DOI:10.1089/adt.2014.579 PMID:25383721
- Yan, F., Yu, Y., Chow, D. C., Palzkill, T., Madoux, F., Hodder, P., Chase, P., Griffin, P. R., O'Malley, B. W., Lonard, D. M. Identification of verrucarin a as a potent and selective steroid receptor coactivator-3 small molecule inhibitor PLoS One 2014 9:e95243 DOI:10.1371/journal.pone.0095243 PMID:24743578 PMCID:PMC3990629
- Lewallen, D. M., Sreelatha, A., Dharmarajan, V., Madoux, F., Chase, P., Griffin, P. R., Orth, K., Hodder, P., Thompson, P. R. Inhibiting AMPylation: a novel screen to identify the first small molecule inhibitors of protein AMPylation ACS Chemical Biology 2014 9:433-442 DOI:10.1021/cb4006886 PMID:24274060 PMCID:PMC3944102
- Satsu, H., Schaeffer, M. T., Guerrero, M., Saldana, A., Eberhart, C., Hodder, P., Cayanan, C., Schurer, S., Bhhatarai, B., Roberts, E., Rosen, H., Brown, S. J. A sphingosine 1-phosphate receptor 2 selective allosteric agonist Bioorganic & Medicinal Chemistry 2013 21:5373-5382 DOI:10.1016/j.bmc.2013.06.012 PMID:23849205 PMCID:PMC3786410
- Thomas, P. W., Spicer, T., Cammarata, M., Brodbelt, J. S., Hodder, P., Fast, W. An altered zinc-binding site confers resistance to a covalent inactivator of New Delhi metallo-beta-lactamase-1 (NDM-1) discovered by high-throughput screening Bioorganic & Medicinal Chemistry 2013 21:3138-3146 DOI:10.1016/j.bmc.2013.03.031 PMID:23591260 PMCID:PMC3651783
- Zhou, L., Lovell, K. M., Frankowski, K. J., Slauson, S. R., Phillips, A. M., Streicher, J. M., Stahl, E., Schmid, C. L., Hodder, P., Madoux, F., Cameron, M. D., Prisinzano, T. E., et al. Development of functionally selective, small molecule agonists at kappa opioid receptors Journal of Biological Chemistry 2013 288:36703-36716 DOI:10.1074/jbc.M113.504381 PMID:24187130 PMCID:PMC3868780
- Gentry, P. R., Bridges, T. M., Lamsal, A., Vinson, P. N., Smith, E., Chase, P., Hodder, P. S., Engers, J. L., Niswender, C. M., Daniels, J. S., Conn, P. J., Wood, M. R., et al. Discovery of ML326: The first sub-micromolar, selective M-5 PAM Bioorganic & Medicinal Chemistry Letters 2013 23:2996-3000 DOI:10.1016/j.bmcl.2013.03.032 PMID:23562060 PMCID:PMC3634896
- Turlington, M., Chun, A., Tomar, S., Eggler, A., Grum-Tokars, V., Jacobs, J., Daniels, J. S., Dawson, E., Saldanha, A., Chase, P., Baez-Santos, Y. M., Lindsley, C. W., et al. Discovery of N-(benzo 1,2,3 triazol-1-yl)-N-(benzyl)acetamido)phenyl) carboxamides as severe acute respiratory syndrome coronavirus (SARS-CoV) 3CLpro inhibitors: Identification of ML300 and noncovalent nanomolar inhibitors with an induced-fit binding Bioorganic & Medicinal Chemistry Letters 2013 23:6172-6177 DOI:10.1016/j.bmcl.2013.08.112 PMID:24080461 PMCID:PMC3878165
- Gentry, P. R., Kokubo, M., Bridges, T. M., Kett, N. R., Harp, J. M., Cho, H. P., Smith, E., Chase, P., Hodder, P. S., Niswender, C. M., Daniels, J. S., Conn, P. J., et al. Discovery of the first M5-selective and CNS penetrant negative allosteric modulator (NAM) of a muscarinic acetylcholine receptor: (S)-9b-(4-chlorophenyl)-1-(3,4-difluorobenzoyl)-2,3-dihydro-1H-imidazo[2,1-a]isoindol-5(9bH)-one (ML375) Journal of Medicinal Chemistry 2013 56:9351-9355 DOI:10.1021/jm4013246 PMID:24164599 PMCID:PMC3876027
- Guerrero, M., Poddutoori, R., Urbano, M., Peng, X., Spicer, T. P., Chase, P. S., Hodder, P. S., Schaeffer, M. T., Brown, S., Rosen, H., Roberts, E. Discovery, design and synthesis of a selective S1P(3) receptor allosteric agonist Bioorganic & Medicinal Chemistry Letters 2013 23:6346-6349 DOI:10.1016/j.bmcl.2013.09.075 PMID:24135724 PMCID:PMC3963471
- Jacobs, J., Grum-Tokars, V., Zhou, Y., Turlington, M., Saldanha, S. A., Chase, P., Eggler, A., Dawson, E. S., Baez-Santos, Y. M., Tomar, S., Mielech, A. M., Baker, S. C., et al. Discovery, synthesis, and structure-based optimization of a series of n-(tert-butyl)-2-(n-arylamido)-2-(pyridin-3-yl) acetamides (ml188) as potent noncovalent small molecule inhibitors of the severe acute respiratory syndrome coronavirus (sars-cov) 3cl protease Journal of Medicinal Chemistry 2013 56:534-546 DOI:10.1021/jm301580n PMID:23231439 PMCID:PMC3569073
- Conn, P. M., Smith, E., Hodder, P., Janovick, J. A., Smithson, D. C. High-throughput screen for pharmacoperones of the vasopressin type 2 receptor Journal of Biomolecular Screening 2013 18:930-937 DOI:10.1177/1087057113483559 PMID:23640875 PMCID:PMC3735853
- Richard, D. J., Lena, R., Bannister, T., Blake, N., Pierceall, W. E., Carlson, N. E., Keller, C. E., Koenig, M., He, Y., Minond, D., Mishra, J., Cameron, M., et al. Hydroxyquinoline-derived compounds and analoguing of selective Mcl-1 inhibitors using a functional biomarker Bioorganic & Medicinal Chemistry 2013 21:6642-6649 DOI:10.1016/j.bmc.2013.08.017 PMID:23993674 PMCID:PMC3831274
- Gomes, I., Fujita, W., Gupta, A., Saldanha, A. S., Negri, A., Pinello, C. E., Roberts, E., Filizola, M., Hodder, P., Devi, L. A. Identification of a μ-δ opioid receptor heteromer-biased agonist with antinociceptive activity Proceedings of the National Academy of Sciences of the United States of America 2013 110:12072-12077 DOI:10.1073/pnas.1222044110 PMID:23818586 PMCID:PMC3718106
- Qin, Q., Knapinska, A., Dobri, N., Madoux, F., Chase, P., Hodder, P., Petrukhin, K. In pursuit of synthetic modulators for the orphan retina-specific nuclear receptor NR2E3 Journal of Ocular Pharmacology and Therapeutics 2013 29:298-309 DOI:10.1089/jop.2012.0135 PMID:23098562 PMCID:PMC3613967
- Nagano, J. M. G., Hsu, K. L., Whitby, L. R., Niphakis, M. J., Speers, A. E., Brown, S. J., Spicer, T., Fernandez-Vega, V., Ferguson, J., Hodder, P., Srinivasan, P., Gonzalez, T. D., et al. Selective inhibitors and tailored activity probes for lipoprotein-associated phospholipase A(2) Bioorganic & Medicinal Chemistry Letters 2013 23:839-843 DOI:10.1016/j.bmcl.2012.11.061 PMID:23260346 PMCID:PMC3549684
- Yang, H., Pinello, C. E., Luo, J., Li, D., Wang, Y., Zhao, L. Y., Jahn, S. C., Saldanha, S. A., Planck, J., Geary, K. R., Ma, H., Law, B. K., et al. Small-molecule inhibitors of acetyltransferase p300 identified by high-throughput screening are potent anticancer agents Molecular Cancer Therapeutics 2013 12:610-620 DOI:10.1158/1535-7163.mct-12-0930 PMID:23625935 PMCID:PMC3651759
- Karapetyan, Y. E., Sferrazza, G. F., Zhou, M., Ottenberg, G., Spicer, T., Chase, P., Fallahi, M., Hodder, P., Weissmann, C., Lasmezas, C. I. Unique drug screening approach for prion diseases identifies tacrolimus and astemizole as antiprion agents Proceedings of the National Academy of Sciences of the United States of America 2013 110:7044-7049 DOI:10.1073/pnas.1303510110 PMID:23576755 PMCID:PMC3637718
- Adibekian, A., Martin, B. R., Chang, J. W., Hsu, K. L., Tsuboi, K., Bachovchin, D. A., Speers, A. E., Brown, S. J., Spicer, T., Fernandez-Vega, V., Ferguson, J., Hodder, P. S., et al. Confirming target engagement for reversible inhibitors in vivo by kinetically tuned activity-based probes Journal of the American Chemical Society 2012 134:10345-10348 DOI:10.1021/ja303400u PMID:22690931 PMCID:PMC3392194
- Urbano, M., Guerrero, M., Zhao, J., Velaparthi, S., Saldanha, S. A., Chase, P., Wang, Z. W., Civelli, O., Hodder, P., Schaeffer, M. T., Brown, S., Rosen, H., et al. Design, synthesis and SAR analysis of novel potent and selective small molecule antagonists of NPBWR1 (GPR7) Bioorganic & Medicinal Chemistry Letters 2012 22:7135-7141 DOI:10.1016/j.bmcl.2012.09.074 PMID:23079522 PMCID:PMC3601546
- Guerrero, M., Urbano, M., Zhao, J., Crisp, M., Chase, P., Hodder, P., Schaeffer, M. T., Brown, S., Rosen, H., Roberts, E. Discovery, design and synthesis of novel potent and selective sphingosine-1-phosphate 4 receptor (s1p(4)-r) agonists Bioorganic & Medicinal Chemistry Letters 2012 22:537-542 DOI:10.1016/j.bmcl.2011.10.096 PMID:22119461 PMCID:PMC3248976
- Amundsen, S. K., Spicer, T., Karabulut, A. C., Londono, L. M., Eberhart, C., Vega, V. F., Bannister, T. D., Hodder, P., Smith, G. R. Small-molecule inhibitors of bacterial AddAB and RecBCD helicase-nuclease DNA repair enzymes ACS Chemical Biology 2012 7:879-891 DOI:10.1021/cb300018x PMID:22443934 PMCID:PMC3356449
- Calamini, B., Silva, M. C., Madoux, F., Hutt, D. M., Khanna, S., Chalfant, M. A., Saldanha, S. A., Hodder, P., Tait, B. D., Garza, D., Balch, W. E., Morimoto, R. I. Small-molecule proteostasis regulators for protein conformational diseases Nature Chemical Biology 2012 8:185-196 DOI:10.1038/nchembio.763 PMID:22198733 PMCID:PMC3262058
- Peatey, C. L., Spicer, T. P., Hodder, P. S., Trenholme, K. R., Gardiner, D. L. A high-throughput assay for the identification of drugs against late-stage Plasmodium falciparum gametocytes Molecular and Biochemical Parasitology 2011 180:127-131 DOI:10.1016/j.molbiopara.2011.09.002 PMID:21939693
- Lone, A. M., Bachovchin, D. A., Westwood, D. B., Speers, A. E., Spicer, T. P., Fernandez-Vega, V., Chase, P., Hodder, P. S., Rosen, H., Cravatt, B. F., Saghatelian, A. A substrate-free activity-based protein profiling screen for the discovery of selective PREPL inhibitors Journal of the American Chemical Society 2011 133:11665-11674 DOI:10.1021/ja2036095 PMID:21692504 PMCID:PMC3145007
- Bachovchin, D. A., Mohr, J. T., Speers, A. E., Wang, C., Berlin, J. M., Spicer, T. P., Fernandez-Vega, V., Chase, P., Hodder, P. S., Schurer, S. C., Nomura, D. K., Rosen, H., et al. Academic cross-fertilization by public screening yields a remarkable class of protein phosphatase methylesterase-1 inhibitors Proceedings of the National Academy of Sciences of the United States of America 2011 108:6811-6816 DOI:10.1073/pnas.1015248108 PMID:21398589 PMCID:PMC3084096
- Istrate, M. A., Spicer, T. P., Wang, Y., Bernard, J. A., Helvering, L. M., Bocchinfuso, W. P., Richardson, T. I., Zink, R., Kumar, N., Montrose-Rafizadeh, C., Dodge, J., Hodder, P., et al. Development of an HTS-compatible assay for discovery of ROR alpha modulators using AlphaScreen (r) technology Journal of Biomolecular Screening 2011 16:183-191 DOI:10.1177/1087057110389040 PMID:21297105 PMCID:PMC4434603
- Urbano, M., Guerrero, M., Velaparthi, S., Crisp, M., Chase, P., Hodder, P., Schaeffer, M. T., Brown, S., Rosen, H., Roberts, E. Discovery, synthesis and sar analysis of novel selective small molecule s1p(4)-r agonists based on a (2z,5z)-5-((pyrrol-3-yl)methylene)-3-alkyl-2-(alkylimino)thiazolidin-4-o ne chemotype Bioorganic & Medicinal Chemistry Letters 2011 21:6739-6745 DOI:10.1016/j.bmcl.2011.09.049 PMID:21982495 PMCID:PMC3209756
- Roth, J., Minond, D., Darout, E., Liu, Q., Lauer, J., Hodder, P., Fields, G. B., Roush, W. R. Identification of novel, exosite-binding matrix metalloproteinase-13 inhibitor scaffolds Bioorganic & Medicinal Chemistry Letters 2011 21:7180-7184 DOI:10.1016/j.bmcl.2011.09.077 PMID:22018790 PMCID:PMC3210410
- Bialkowska, A. B., Crisp, M., Bannister, T., He, Y. J., Chowdhury, S., Schurer, S., Chase, P., Spicer, T., Madoux, F., Tian, C. L., Hodder, P., Zaharevitz, D., et al. Identification of small-molecule inhibitors of the colorectal cancer oncogene Kruppel-like factor 5 expression by ultrahigh-throughput screening Molecular Cancer Therapeutics 2011 10:2043-2051 DOI:10.1158/1535-7163.mct-11-0550 PMID:21885866 PMCID:PMC3213326
- Baillargeon, P., Scampavia, L., Einsteder, R., Hodder, P. Monitoring of HTS compound library quality via a high-resolution image acquisition and processing instrument JALA 2011 16:197-203 DOI:10.1016/j.jala.2011.02.004 PMID:21609702 PMCID:PMC3417353
- Tsuboi, K., Bachovchin, D. A., Speers, A. E., Spicer, T. P., Fernandez-Vega, V., Hodder, P., Rosen, H., Cravatt, B. F. Potent and selective inhibitors of glutathione S-transferase omega 1 that impair cancer drug resistance Journal of the American Chemical Society 2011 133:16605-16616 DOI:10.1021/ja2066972 PMID:21899313 PMCID:PMC3226709
- Chou, T. F., Brown, S. J., Minond, D., Nordin, B. E., Li, K. L., Jones, A. C., Chase, P., Porubsky, P. R., Stoltz, B. M., Schoenen, F. J., Patricelli, M. P., Hodder, P., et al. Reversible inhibitor of p97, dbeq, impairs both ubiquitin-dependent and autophagic protein clearance pathways Proceedings of the National Academy of Sciences of the United States of America 2011 108:4834-4839 DOI:10.1073/pnas.1015312108 PMID:21383145 PMCID:PMC3064330
- Brunell, D., Weissbach, H., Hodder, P., Brot, N. A high-throughput screening compatible assay for activators and inhibitors of methionine sulfoxide reductase a Assay and Drug Development Technologies 2010 8:615-620 DOI:10.1089/adt.2009.0263 PMID:20515413 PMCID:PMC2978062
- Kota, S., Scampavia, L., Spicer, T., Beeler, A. B., Takahashi, V., Snyder, J. K., Porco, J. A., Hodder, P., Strosberg, A. D. A time-resolved fluorescence-resonance energy transfer assay for identifying inhibitors of hepatitis C virus core dimerization Assay and Drug Development Technologies 2010 8:96-105 DOI:10.1089/adt.2009.0217 PMID:20035614 PMCID:PMC2971647
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- Tanaka, K., Koresawa, M., Iida, M., Fukasawa, K., Stec, E., Cassaday, J., Chase, P., Rickert, K., Hodder, P., Takagi, T., Komatani, H. Multiplexed random peptide library and phospho-specific antibodies facilitate human polo-like kinase 1 inhibitor screen Assay and Drug Development Technologies 2010 8:47-62 DOI:10.1089/adt.2009.0212 PMID:20085455 PMCID:PMC3532019
- Weide, T., Saldanha, S. A., Minond, D., Spicer, T. P., Fotsing, J. R., Spaargaren, M., Frere, J. M., Bebrone, C., Sharpless, K. B., Hodder, P. S., Fokin, V. V. NH-1,2,3-triazole-based inhibitors of the VIM-2 Metallo-beta-Lactamase: synthesis and structure-activity studies ACS Medicinal Chemistry Letters 2010 1:150-154 DOI:10.1021/ml900022q PMID:20625539 PMCID:PMC2901175
- Bachovchin, D. A., Wolfe, M. R., Masuda, K., Brown, S. J., Spicer, T. P., Fernandez-Vega, V., Chase, P., Hodder, P. S., Rosen, H., Cravatt, B. F. Oxime esters as selective, covalent inhibitors of the serine hydrolase retinoblastoma-binding protein 9 (RBBP9) Bioorganic & Medicinal Chemistry Letters 2010 20:2254-2258 DOI:10.1016/j.bmcl.2010.02.011 PMID:20207142 PMCID:PMC2843764
- Brothers, S. P., Saldanha, S. A., Spicer, T. P., Cameron, M., Mercer, B. A., Chase, P., McDonald, P., Wahlestedt, C., Hodder, P. S. Selective and brain penetrant neuropeptide y y2 receptor antagonists discovered by whole-cell high-throughput screening Molecular Pharmacology 2010 77:46-57 DOI:10.1124/mol.109.058677 PMID:19837904 PMCID:PMC2802430
- Grimm, C., Jors, S., Saldanha, S. A., Obukhov, A. G., Pan, B. F., Oshima, K., Cuajungco, M. P., Chase, P., Hodder, P., Heller, S. Small molecule activators of TRPML3 Chemistry & Biology 2010 17:135-148 DOI:10.1016/j.chembiol.2009.12.016 PMID:20189104 PMCID:PMC2834294
- Lauer-Fields, J. L., Minond, D., Chase, P. S., Baillargeon, P. E., Saldanha, S. A., Stawikowska, R., Hodder, P., Fields, G. B. High throughput screening of potentially selective mmp-13 exosite inhibitors utilizing a triple-helical fret substrate Bioorganic & Medicinal Chemistry 2009 17:990-1005 DOI:10.1016/j.bmc.2008.03.004 PMID:18358729 PMCID:PMC3298815
- Doghman, M., Cazareth, J., Douguet, D., Madoux, F., Hodder, P., Lalli, E. Inhibition of adrenocortical carcinoma cell proliferation by steroidogenic factor-1 inverse agonists Journal of Clinical Endocrinology & Metabolism 2009 94:2178-2183 DOI:10.1210/jc.2008-2163 PMID:19318454 PMCID:PMC2690427
- Minond, D., Saldanha, S. A., Subramaniam, P., Spaargaren, M., Spicer, T., Fotsing, J. R., Weide, T., Fokin, V. V., Sharpless, K. B., Galleni, M., Bebrone, C., Lassaux, P., et al. Inhibitors of VIM-2 by screening pharmacologically active and click-chemistry compound libraries Bioorganic & Medicinal Chemistry 2009 17:5027-5037 DOI:10.1016/j.bmc.2009.05.070 PMID:19553129 PMCID:PMC2759276
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- Schroeter, T., Minond, D., Weiser, A., Dao, C., Habel, J., Spicer, T., Chase, P., Baillargeon, P., Scampavia, L., Schuerer, S., Chung, C., Mader, C., et al. Comparison of miniaturized time-resolved fluorescence resonance energy transfer and enzyme-coupled luciferase high-throughput screening assays to discover inhibitors of Rho-kinase II (ROCK-II) Journal of Biomolecular Screening 2008 13:17-28 DOI:10.1177/1087057107310806 PMID:18227223
- Schurer, S. C., Brown, S. J., Gonzalez-Cabrera, P. J., Schaeffer, M. T., Chapman, J., Jo, E., Chase, P., Spicer, T., Hodder, P., Rosen, H. Ligand-binding pocket shape differences between sphingosine 1-phosphate (S1P) receptors S1P1 and S1P3 determine efficiency of chemical probe identification by ultrahigh-throughput screening ACS Chemical Biology 2008 3:486-498 DOI:10.1021/cb800051m PMID:18590333 PMCID:PMC2597349
- Madoux, F., Li, X. L., Chase, P., Zastrow, G., Cameron, M. D., Conkright, J. J., Griffin, P. R., Thacher, S., Hodder, P. Potent, selective and cell penetrant inhibitors of SF-1 by functional ultra-high-throughput screening Molecular Pharmacology 2008 73:1776-1784 DOI:10.1124/mol.108.045963 PMID:18334597 PMCID:PMC3228235
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- Roth, J., Madoux, F., Hodder, P., Roush, W. R. Synthesis of small molecule inhibitors of the orphan nuclear receptor steroidogenic factor-1 (NR5A1) based on isoquinolinone scaffolds Bioorganic & Medicinal Chemistry Letters 2008 18:2628-2632 DOI:10.1016/j.bmcl.2008.03.027 PMID:18374567 PMCID:PMC2592603
- Zuck, P., O'Donnell, G. T., Cassaday, J., Chase, P., Hodder, P., Strulovici, B., Ferrer, M. Miniaturization of absorbance assays using the fluorescent properties of white microplates Analytical Biochemistry 2005 342:254-259 DOI:10.1016/j.ab.2005.04.029 PMID:15949786
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- Hodder, P., Cassaday, J., Peltier, R., Berry, K., Inglese, J., Feuston, B., Culberson, C., Bleicher, L., Cosford, N. D. P., Bayly, C., Suto, C., Varney, M., et al. Identification of metabotropic glutamate receptor antagonists using an automated high-throughput screening system Analytical Biochemistry 2003 313:246-254 DOI:10.1016/s0003-2697(02)00608-5 PMID:12605861
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- Scampavia, L. D., Hodder, P. S., Lahdesmaki, I., Ruzicka, J. Automation of functional assays by flow injection fluorescence microscopy Trends in Biotechnology 1999 17:443-447 DOI:10.1016/s0167-7799(99)01375-x PMID:10511702
- Hodder, P. S., Blankenstein, G., Ruzicka, J. Microfabricated flow chamber for fluorescence-based chemistries and stopped-flow injection cytometry Analyst 1997 122:883-887 DOI:10.1039/a701750b PMID:9374023
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- Busby, S., Nuhant, P., Cameron, M., Mercer, B. A., Hodder, P., Roush, W. R., Griffin, P. R. Discovery of inverse agonists for the liver receptor homologue-1 (LRH1; NR5A2) 2010
- Kumar, N., Nuhant, P., Solt, L. A., Conkright, J. J., Wang, Y., Istrate, M. A., Busby, S. A., Ruben, D. G. O., Burris, T. P., Cameron, M., Mercer, B. A., Hodder, P., et al. Identification of a novel selective inverse agonist probe and analogs for the Retinoic acid receptor-related Orphan Receptor Alpha (RORalpha) 2010
- Kumar, N., Kamenecka, T., Lyda, B., Khan, P., Chang, M. R., Garcia-Ordonez, R. D., Cameron, M., Ferguson, J., Mercer, B. A., Hodder, P., Rosen, H., Griffin, P. R. Identification of a novel selective inverse agonist probe and analogs for the Retinoic acid receptor-related Orphan Receptor Gamma (RORgamma) 2010
- Simanski, S., Madoux, F., Rahaim, R. J., Chase, P., Schurer, S., Cameron, M., Mercer, B. A., Hodder, P., Roush, W. R., Ayad, N. G. Identification of small molecule inhibitors of Wee1 degradation and mitotic entry 2010
- Kota, S., Madoux, F., Chase, P., Takahashi, V., Liu, Q., Mercer, B. A., Cameron, M., Strosberg, A. D., Roush, W., Hodder, P. ML322, a small molecule inhibitor of dimerization of the core protein of hepatitis C virus (HCV) 2010
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- Kamenecka, T. M., Busby, S. A., Kumar, N., Choi, J. H., Banks, A. S., Vidovic, D., Cameron, M. D., Schurer, S. C., Mercer, B. A., Hodder, P., Spiegelman, B. M., Griffin, P. R. Potent anti-diabetic actions of a novel non-agonist PPARγ ligand that blocks Cdk5-mediated phosphorylation 2010
- Hulce, J. J., Joslyn, C., Speers, A. E., Brown, S. J., Spicer, T., Fernandez-Vega, V., Ferguson, J., Cravatt, B. F., Hodder, P., Rosen, H. An in vivo active carbamate-based dual inhibitor of lysophospholipase 1 (LYPLA1) and lysophospholipase 2 (LYPLA2) Probe Reports from the NIH Molecular Libraries Program. 2010 PMID:25506974
- Adibekian, A., Martin, B. R., Chang, J. W., Hsu, K. L., Tsuboi, K., Bachovchin, D. A., Speers, A. E., Brown, S. J., Spicer, T., Fernandez-Vega, V., Ferguson, J., Cravatt, B. F., et al. Characterization of a Selective, Reversible Inhibitor of Lysophospholipase 2 (LYPLA2) Probe Reports from the NIH Molecular Libraries Program. 2010 PMID:24624468
- Adibekian, A., Martin, B. R., Chang, J. W., Hsu, K. L., Tsuboi, K., Bachovchin, D. A., Speers, A. E., Brown, S. J., Spicer, T., Fernandez-Vega, V., Ferguson, J., Cravatt, B. F., et al. Characterization of a selective, reversible inhibitor of lysophospholipase 1 (LYPLA1) Probe Reports from the NIH Molecular Libraries Program. 2010 PMID:24624465
- Minond, D., Saldanha, S. A., Spicer, T., Qin, L., Mercer, B. A., Roush, W. R., Hodder, P. HTS assay for discovery of novel metallo-beta-lactamase (MBL) inhibitors Probe Reports from the NIH Molecular Libraries Program. 2010 PMID:21961119
- Schoenen, F. J., Whipple, D., Baillargeon, P., Brown, C. L., Chase, P., Ferguson, J., Fernandez-Vega, V., Hodder, P., Mathew, R., Neuenswander, B., Porubsky, P., Rogers, S., et al. Inhibitors of the Plasmodium falciparum M17 leucine aminopeptidase Probe Reports from the NIH Molecular Libraries Program. 2010 PMID:25506973
- Schoenen, F. J., Weiner, W. S., Baillargeon, P., Brown, C. L., Chase, P., Ferguson, J., Fernandez-Vega, V., Ghosh, P., Hodder, P., Krise, J. P., Matharu, D. S., Neuenswander, B., et al. Inhibitors of the Plasmodium falciparum M18 aspartyl aminopeptidase Probe Reports from the NIH Molecular Libraries Program. 2010 PMID:24479194
- Bialkowska, A., Crisp, M., Madoux, F., Spicer, T., Knapinska, A., Mercer, B., Bannister, T. D., He, Y., Chowdhury, S., Cameron, M., Yang, V. W., Hodder, P. ML264: An antitumor agent that potently and selectively inhibits kruppel-like factor five (KLF5) expression: a probe for studying colon cancer development and progression Probe Reports from the NIH Molecular Libraries Program. 2010 PMID:23762940
- Spicer, T., Minond, D., Enogieru, I., Saldanha, S. A., Allais, C., Liu, Q., Mercer, B. A., Roush, W. R., Hodder, P. ML302, a novel beta-lactamase (BLA) inhibitor Probe Reports from the NIH Molecular Libraries Program. 2010 PMID:23762954
- Bannister, T., Koenig, M., He, Y., Mishra, J., Spicer, T., Minond, D., Saldanha, A., Mercer, B. A., Cameron, M., Lena, R., Carlson, N., Richard, D., et al. ML311: A small molecule that potently and selectively disrupts the protein-protein interaction of Mcl-1 and Bim: a probe for studying lymphoid tumorigenesis Probe Reports from the NIH Molecular Libraries Program. 2010 PMID:23762927
- Bannister, T. D., Nair, R., Spicer, T., Fernandez Vega, V., Eberhart, C., Mercer, B. A., Cameron, M., Schurer, S., Amundsen, S. K., Karabulut, A., Londono, L. M., Smith, G. R., et al. ML328: A novel dual inhibitor of bacterial AddAB and RecBCD helicase-nuclease DNA repair enzymes Probe Reports from the NIH Molecular Libraries Program. 2010 PMID:23833795
- Nagano, J. M. G., Hsu, K. L., Speers, A. E., Brown, S. J., Spicer, T., Fernandez-Vega, V., Ferguson, J., Bahnson, B. J., Cravatt, B. F., Hodder, P., Rosen, H. Optimization and characterization of a carbamate inhibitor for plasma platelet-activating factor acetylhydrolase (pPAFAH) Probe Reports from the NIH Molecular Libraries Program. 2010 PMID:23658952
- Dreyton, C. J., Jones, J. E., Knuckley, B. A., Subramanian, V., Anderson, E. D., Brown, S. J., Fernandez-Vega, V., Eberhart, C., Spicer, T., Zuhl, A. M., Ferguson, J., Speers, A. E., et al. Optimization and characterization of a pan protein arginine deiminase (PAD) inhibitor Probe Reports from the NIH Molecular Libraries Program. 2010 PMID:23833800
- Adibekian, A., Martin, B. R., Speers, A. E., Brown, S. J., Spicer, T., Fernandez-Vega, V., Ferguson, J., Cravatt, B. F., Hodder, P., Rosen, H. Optimization and characterization of a triazole urea dual inhibitor for lysophospholipase 1 (LYPLA1) and lysophospholipase 2 (LYPLA2) Probe Reports from the NIH Molecular Libraries Program. 2010 PMID:23658947
- Adibekian, A., Hsu, K. L., Speers, A. E., Brown, S. J., Spicer, T., Fernandez-Vega, V., Ferguson, J., Cravatt, B. F., Hodder, P., Rosen, H. Optimization and characterization of a triazole urea inhibitor for alpha/beta hydrolase domain-containing protein 11 (ABHD11): anti-probe for LYPLA1/LYPLA2 dual inhibitor ML211 Probe Reports from the NIH Molecular Libraries Program. 2010 PMID:23658953
- Hsu, K. L., Tsuboi, K., Speers, A. E., Brown, S. J., Spicer, T., Fernandez-Vega, V., Ferguson, J., Cravatt, B. F., Hodder, P., Rosen, H. Optimization and characterization of a triazole urea inhibitor for diacylglycerol lipase beta (DAGL-beta) Probe Reports from the NIH Molecular Libraries Program. 2010 PMID:23658950
- Adibekian, A., Hsu, K. L., Speers, A. E., Monillas, E. S., Brown, S. J., Spicer, T., Fernandez-Vega, V., Ferguson, J., Bahnson, B. J., Cravatt, B. F., Hodder, P., Rosen, H. Optimization and characterization of a triazole urea inhibitor for platelet-activating factor acetylhydrolase type 2 (PAFAH2) Probe Reports from the NIH Molecular Libraries Program. 2010 PMID:23658960
- Tsuboi, K., Bachovchin, D. A., Speers, A. E., Brown, S. J., Spicer, T., Fernandez-Vega, V., Ferguson, J., Cravatt, B. F., Hodder, P., Rosen, H. Optimization and characterization of an inhibitor for glutathione S-tranferase omega 1 (GSTO1) Probe Reports from the NIH Molecular Libraries Program. 2010 PMID:22834034
- Hsu, K. L., Tsuboi, K., Speers, A. E., Brown, S. J., Spicer, T., Fernandez-Vega, V., Ferguson, J., Cravatt, B. F., Hodder, P., Rosen, H. Optimization and characterization of triazole urea inhibitors for abhydrolase domain containing protein 6 (ABHD6) Probe Reports from the NIH Molecular Libraries Program. 2010 PMID:23762934
- Guerrero, M., Poddutoori, R., Pinacho-Crisostomo, F., Schaeffer, M. T., Brown, S. J., Spicer, T., Chase, P., Ferguson, J., Roberts, E., Sanna, G., Hodder, P., Rosen, H. Probe development efforts for an allosteric agonist of the sphingosine 1-phosphate receptor 3 (S1P3) Probe Reports from the NIH Molecular Libraries Program. 2010 PMID:23658964
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- Bachovchin, D. A., Speers, A. E., Brown, S. J., Spicer, T. P., Fernandez, Vega, Ferguson, J., Mohr, J. T., Murphy, J., Fu, G. C., Cravatt, B. F., Hodder, P. S., Rosen, H. Probe development efforts to identify novel inhibitors of protein phosphatase methylesterase-1 (PME-1) Probe Reports from the NIH Molecular Libraries Program. 2010 PMID:22834039
- Saldanha, S. A., Brothers, S. P., Spicer, T., Cameron, M., Mercer, B. A., Chase, P., McDonald, P., Wahlestedt, C., Hodder, P. S. Probe report for NPY-Y2 receptor antagonists Probe Reports from the NIH Molecular Libraries Program. 2010 PMID:21433370
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- Brown, S. J., Bachovchin, D. A., Cravatt, B. F., Fernandez-Vega, V., Spicer, T., Mercer, B. A., Hodder, P., Rosen, H. R. Probe report for RBBP9 inhibitors - Probe 1 Probe Reports from the NIH Molecular Libraries Program. 2010 PMID:21433353
- Bachovchin, D. A., Speers, A. E., Brown, S. J., Cravatt, B. F., Spicer, T., Mercer, B. A., Ferguson, J., Hodder, P., Rosen, H. R. Probe report for RBBP9 inhibitors - Probe 2 Probe Reports from the NIH Molecular Libraries Program. 2010 PMID:21433382

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