Scripps VIVO scripps research logo

  • Index
  • Log in
  • Home
  • People
  • Organizations
  • Research
  • Events
Search form
Hodder, Peter
Publications in VIVO
 
    Export Publications Table
co-author
Co-author Network
map of science
Map of Science

Hodder, Peter

Faculty Member
share the uri qr icon Close

Positions

  • 2007 - 2013 Associate Professor of Molecular Therapeutics (Joint Appointment), Molecular Therapeutics , Scripps Research
  • 2005 - 2013 Adjunct Professor of Electrical Engineering & Bioengineering, Department of Electrical Engineering, Florida Atlantic University
  • 2005 - 2013 Senior Scientific Director, Translational Research Institute , Scripps Research
  • 2005 - 2013 Director, Lead Identification, Translational Research Institute , Scripps Research
  • 2005 - 2012 Director, Molecular Screening Center , Scripps Research
  • 2003 - 2005 Research Fellow, Department of Automated Biotechnology, Merck Research Laboratories, Merck & Co., Inc.
  • 1999 - 2003 Senior Research Biochemist, Department of Automated Biotechnology, Merck Research Laboratories, Merck & Co., Inc.

Research Areas research areas

  • Hepatitis C (UMLS)
  • Publications
  • Affiliation
  • Research
  • Background
  • Contact
  • View All
scroll to property group menus

Publications

recent publications

  • academic article

    • Wang, L. M., Cheng, C. M., Qin, J., Xu, M. F., Kao, C. Y., Shi, J. J., You, E. L., Gong, W. C., Rosa, L. P., Chase, P., Scampavia, L., Madoux, F., et al. Small-molecule inhibitor targeting orphan nuclear receptor COUP-TFII for prostate cancer treatment Science Advances  2020 6  DOI:10.1126/sciadv.aaz8031  PMID:32494682  PMCID:PMC7190335
    • Spicer, T. P., Gardiner, D. L., Schoenen, F. J., Roy, S., Griffin, P. R., Chase, P., Scampavia, L., Hodder, P., Trenholme, K. R. Identification of antimalarial inhibitors using late-stage gametocytes in a phenotypic live/dead sssay SLAS Discovery  2019 24:38-46  DOI:10.1177/2472555218796410  PMID:30142014
    • Nieto, A., Fernandez-Vega, V., Spicer, T. P., Sturchler, E., Adhikari, P., Kennedy, N., Mandat, S., Chase, P., Scampavia, L., Bannister, T., Hodder, P., McDonald, P. H. Identification of Novel, Structurally Diverse, Small Molecule Modulators of GPR119 Assay and Drug Development Technologies  2018 16:278-288  DOI:10.1089/adt.2018.849  PMID:30019946  PMCID:PMC6065524
    • Swingle, M., Volmar, C. H., Saldanha, S. A., Chase, P., Eberhart, C., Salter, E. A., D'Arcy, B., Schroeder, C. E., Golden, J. E., Wierzbicki, A., Hodder, P., Honkanen, R. E. An ultra-high-throughput screen for catalytic inhibitors of serine/threonine protein phosphatases types 1 and 5 (PP1C and PP5C) SLAS Discovery  2017 22:21-31  DOI:10.1177/1087057116668852  PMID:27628691
    • Wang, J., Fang, P. F., Chase, P., Tshori, S., Razin, E., Spicer, T. P., Scampavia, L., Hodder, P., Guo, M. Development of an HTS-compatible assay for discovery of melanoma-related microphthalmia transcription factor disruptors using AlphaScreen technology SLAS Discovery  2017 22:58-66  DOI:10.1177/1087057116675274  PMID:27827304
    • Ewing, H., Fernandez-Vega, V., Spicer, T. P., Chase, P., Brown, S., Scampavia, L., Roush, W. R., Riley, S., Rosen, H., Hodder, P., Lambeau, G., Gelb, M. H. Fluorometric high-throughput screening assay for secreted phospholipases A(2) using phospholipid vesicles Journal of Biomolecular Screening  2016 21:713-721  DOI:10.1177/1087057116646742  PMID:27146384
    • Plate, L., Cooley, C. B., Chen, J. J., Paxman, R. J., Gallagher, C. M., Madoux, F., Genereux, J. C., Dobbs, W., Garza, D., Spicer, T. P., Scampavia, L., Brown, S. J., et al. Small molecule proteostasis regulators that reprogram the ER to reduce extracellular protein aggregation Elife  2016 5  DOI:10.7554/eLife.15550  PMID:27435961  PMCID:PMC4954754
    • Abdul-Hay, S. O., Bannister, T. D., Wang, H., Cameron, M. D., Caulfield, T. R., Masson, A., Bertrand, J., Howard, E. A., McGuire, M. P., Crisafulli, U., Rosenberry, T. R., Topper, C. L., et al. Selective targeting of extracellular insulin-degrading enzyme by quasi-irreversible thiol-modifying inhibitors ACS Chemical Biology  2015 10:2716-2724  DOI:10.1021/acs.chembio.5b00334  PMID:26398879
    • Sanders, M. A., Madoux, F., Mladenovic, L., Zhang, H., Ye, X., Angrish, M., Mottillo, E. P., Caruso, J. A., Halvorsen, G., Roush, W. R., Chase, P., Hodder, P., et al. Endogenous and synthetic ABHD5 ligands regulate ABHD5-perilipin interactions and lipolysis in fat and muscle Cell Metabolism  2015 22:851-860  DOI:10.1016/j.cmet.2015.08.023  PMID:26411340  PMCID:PMC4862007
    • Smith, E., Chase, P., Niswender, C. M., Utley, T. J., Sheffler, D. J., Noetzel, M. J., Lamsal, A., Wood, M. R., Conn, P. J., Lindsley, C. W., Madoux, F., Acosta, M., et al. Application of parallel multiparametric cell-based FLIPR detection assays for the identification of modulators of the muscarinic acetylcholine receptor 4 (M-4) Journal of Biomolecular Screening  2015 20:858-868  DOI:10.1177/1087057115581770  PMID:25877150  PMCID:PMC4659430
    • Schreiber, S. L., Kotz, J. D., Li, M., Aube, J., Austin, C. P., Reed, J. C., Rosen, H., White, E. L., Sklar, L. A., Lindsley, C. W., Alexander, B. R., Bittker, J. A., et al. Advancing biological understanding and therapeutics discovery with small-molecule probes Cell  2015 161:1252-1265  DOI:10.1016/j.cell.2015.05.023  PMID:26046436  PMCID:PMC4564295
    • Chang, J. W., Zuhl, A. M., Speers, A. E., Niessen, S., Brown, S. J., Mulvihill, M. M., Fan, Y. C., Spicer, T. P., Southern, M., Scampavia, L., Fernandez-Vega, V., Dix, M. M., et al. Selective inhibitor of platelet-activating factor acetylhydrolases 1b2 and 1b3 that impairs cancer cell survival ACS Chemical Biology  2015 10:925-932  DOI:10.1021/cb500893q  PMID:25602368  PMCID:PMC4402257
    • Ting, P. Y., Damoiseaux, R., Titz, B., Bradley, K. A., Graeber, T. G., Fernandez-Vega, V., Bannister, T. D., Chase, P., Nair, R., Scampavia, L., Hodder, P., Spicer, T. P., et al. Identification of small molecules that disrupt signaling between ABL and its positive regulator RIN1 PLoS One  2015 10:e0121833  DOI:10.1371/journal.pone.0121833  PMID:25811598  PMCID:PMC4374917
    • Wang, Y., Stowe, R. L., Pinello, C. E., Tian, G., Madoux, F., Li, D., Zhao, L. Y., Li, J. L., Wang, Y., Wang, Y., Ma, H., Hodder, P., et al. Identification of histone deacetylase inhibitors with benzoylhydrazide scaffold that selectively inhibit class I histone deacetylases Chemistry & Biology  2015 22:273-284  DOI:10.1016/j.chembiol.2014.12.015  PMID:25699604  PMCID:PMC4365786
    • Zhao, N., Darby, C. M., Small, J., Bachovchin, D. A., Jiang, X., Burns-Huang, K. E., Botella, H., Ehrt, S., Boger, D. L., Anderson, E. D., Cravatt, B. F., Speers, A. E., et al. Target-based screen against a periplasmic serine protease that regulates intrabacterial pH homeostasis in Mycobacterium tuberculosis ACS Chemical Biology  2015 10:364-371  DOI:10.1021/cb500746z  PMID:25457457  PMCID:PMC4340348
    • Han, C., Chatterjee, A., Noetzel, M. J., Panarese, J. D., Smith, E., Chase, P., Hodder, P., Niswender, C., Conn, P. J., Lindsley, C. W., Stauffer, S. R. Discovery and SAR of muscarinic receptor subtype 1 (M-1) allosteric activators from a molecular libraries high throughput screen. Part 1: 2,5-Dibenzyl-2H-pyrazolo 4,3-c quinolin-3(5H)-ones as positive allosteric modulators Bioorganic & Medicinal Chemistry Letters  2015 25:384-388  DOI:10.1016/j.bmcl.2014.11.011  PMID:25435150  PMCID:PMC4278958
    • Pedro-Rosa, L., Buckner, F. S., Ranade, R. M., Eberhart, C., Madoux, F., Gillespie, J. R., Koh, C. Y., Brown, S., Lohse, J., Verlinde, C. L. M., Fan, E., Bannister, T., et al. Identification of potent inhibitors of the Trypanosoma brucei methionyl-tRNA synthetase via high-throughput orthogonal screening Journal of Biomolecular Screening  2015 20:122-130  DOI:10.1177/1087057114548832  PMID:25163684  PMCID:PMC4378865
    • Kadakkuzha, B. M., Spicer, T. P., Chase, P., Richman, J. B., Hodder, P., Puthanveettil, S. V. High-throughput screening for small molecule modulators of motor protein Kinesin Assay and Drug Development Technologies  2014 12:470-480  DOI:10.1089/adt.2014.579  PMID:25383721
    • Gentry, P. R., Kokubo, M., Bridges, T. M., Noetzel, M. J., Cho, H. P., Lamsal, A., Smith, E., Chase, P., Hodder, P. S., Niswender, C. M., Daniels, J. S., Conn, P. J., et al. Development of a highly potent, novel M(5) positive allosteric modulator (PAM) demonstrating CNS exposure: 1-((1H-indazol-5-yl)sulfoneyl)-N-ethyl-N-(2-(trifluoromethyl)benzyl)pipe ridine-4-carboxamide (ML380) Journal of Medicinal Chemistry  2014 57:7804-7810  DOI:10.1021/jm500995y  PMID:25147929  PMCID:PMC4175000
    • Madoux, F., Tredup, C., Scampavia, L., Chase, P. S., Hodder, P. S., Fields, G. B., Becker-Pauly, C., Minond, D., Spicer, T. P. Development of high throughput screening assays and pilot screen for inhibitors of metalloproteases meprin α and β Biopolymers  2014 102:396-406  DOI:10.1002/bip.22527  PMID:25048711  PMCID:PMC4339026
    • Gentry, P. R., Kokubo, M., Bridges, T. M., Cho, H. P., Smith, E., Chase, P., Hodder, P. S., Utley, T. J., Rajapakse, A., Byers, F., Niswender, C. M., Morrison, R. D., et al. Discovery, synthesis and characterization of a highly muscarinic acetylcholine receptor (mAChR)-selective M5-orthosteric antagonist, VU0488130 (ML381): a novel molecular probe ChemMedChem  2014 9:1677-1682  DOI:10.1002/cmdc.201402051  PMID:24692176  PMCID:PMC4116439
    • Spicer, T., Fernandez-Vega, V., Chase, P., Scampavia, L., To, J., Dalton, J. P., Da Silva, F. L., Skinner-Adams, T. S., Gardiner, D. L., Trenholme, K. R., Brown, C. L., Ghosh, P., et al. Identification of potent and selective inhibitors of the plasmodium falciparum M18 aspartyl aminopeptidase (PfM18AAP) of human malaria via high-throughput screening Journal of Biomolecular Screening  2014 19:1107-1115  DOI:10.1177/1087057114525852  PMID:24619116  PMCID:PMC4641816
    • Penas, C., Ramachandran, V., Simanski, S., Lee, C., Madoux, F., Rahaim, R. J., Chauhan, R., Barnaby, O., Schurer, S., Hodder, P., Steen, J., Roush, W. R., et al. Casein kinase 1 delta-dependent Wee1 protein degradation Journal of Biological Chemistry  2014 289:18893-18903  DOI:10.1074/jbc.M114.547661  PMID:24817118  PMCID:PMC4081930
    • Sturchler, E., Chen, W., Spicer, T., Hodder, P., McDonald, P., Duckett, D. Development of an HTS-compatible assay for the discovery of ASK1 signalosome inhibitors using alphascreen technology Assay and Drug Development Technologies  2014 12:229-237  DOI:10.1089/adt.2013.558  PMID:24831789  PMCID:PMC4025566
    • Yan, F., Yu, Y., Chow, D. C., Palzkill, T., Madoux, F., Hodder, P., Chase, P., Griffin, P. R., O'Malley, B. W., Lonard, D. M. Identification of verrucarin a as a potent and selective steroid receptor coactivator-3 small molecule inhibitor PLoS One  2014 9:e95243  DOI:10.1371/journal.pone.0095243  PMID:24743578  PMCID:PMC3990629
    • Lewallen, D. M., Bicker, K. L., Madoux, F., Chase, P., Anguish, L., Coonrod, S., Hodder, P., Thompson, P. R. A FluoPol-ABPP PAD2 high-throughput screen identifies the first calcium site inhibitor targeting the PADs ACS Chemical Biology  2014 9:913-921  DOI:10.1021/cb400841k  PMID:24467619  PMCID:PMC4108211
    • Wang, Y., Lonard, D. M., Yu, Y., Chow, D. C., Palzkill, T. G., Wang, J., Qi, R., Matzuk, A. J., Song, X., Madoux, F., Hodder, P., Chase, P., et al. Bufalin is a potent small-molecule inhibitor of the steroid receptor coactivators SRC-3 and SRC-1 Cancer Research  2014 74:1506-1517  DOI:10.1158/0008-5472.can-13-2939  PMID:24390736  PMCID:PMC3947477
    • Lewallen, D. M., Sreelatha, A., Dharmarajan, V., Madoux, F., Chase, P., Griffin, P. R., Orth, K., Hodder, P., Thompson, P. R. Inhibiting AMPylation: a novel screen to identify the first small molecule inhibitors of protein AMPylation ACS Chemical Biology  2014 9:433-442  DOI:10.1021/cb4006886  PMID:24274060  PMCID:PMC3944102
    • Jiang, J., Taylor, A. B., Choi, J. Y., Hart, P. J., Roush, W. R., Fields, G. B., Hodder, P. S., Minong, D., Spicer, T. P. Characterization of selective exosite-binding inhibitors of matrix metalloproteinase 13 that prevent articular cartilage degradation in vitro Journal of Medicinal Chemistry  2014 57:9598-9611  DOI:10.1021/jm501284e  PMID:25330343  PMCID:PMC4255739
    • Zhou, L., Lovell, K. M., Frankowski, K. J., Slauson, S. R., Phillips, A. M., Streicher, J. M., Stahl, E., Schmid, C. L., Hodder, P., Madoux, F., Cameron, M. D., Prisinzano, T. E., et al. Development of functionally selective, small molecule agonists at kappa opioid receptors Journal of Biological Chemistry  2013 288:36703-36716  DOI:10.1074/jbc.M113.504381  PMID:24187130  PMCID:PMC3868780
    • Guerrero, M., Poddutoori, R., Urbano, M., Peng, X., Spicer, T. P., Chase, P. S., Hodder, P. S., Schaeffer, M. T., Brown, S., Rosen, H., Roberts, E. Discovery, design and synthesis of a selective S1P(3) receptor allosteric agonist Bioorganic & Medicinal Chemistry Letters  2013 23:6346-6349  DOI:10.1016/j.bmcl.2013.09.075  PMID:24135724  PMCID:PMC3963471
    • Gentry, P. R., Kokubo, M., Bridges, T. M., Kett, N. R., Harp, J. M., Cho, H. P., Smith, E., Chase, P., Hodder, P. S., Niswender, C. M., Daniels, J. S., Conn, P. J., et al. Discovery of the first M5-selective and CNS penetrant negative allosteric modulator (NAM) of a muscarinic acetylcholine receptor: (S)-9b-(4-chlorophenyl)-1-(3,4-difluorobenzoyl)-2,3-dihydro-1H-imidazo[2,1-a]isoindol-5(9bH)-one (ML375) Journal of Medicinal Chemistry  2013 56:9351-9355  DOI:10.1021/jm4013246  PMID:24164599  PMCID:PMC3876027
    • Turlington, M., Chun, A., Tomar, S., Eggler, A., Grum-Tokars, V., Jacobs, J., Daniels, J. S., Dawson, E., Saldanha, A., Chase, P., Baez-Santos, Y. M., Lindsley, C. W., et al. Discovery of N-(benzo 1,2,3 triazol-1-yl)-N-(benzyl)acetamido)phenyl) carboxamides as severe acute respiratory syndrome coronavirus (SARS-CoV) 3CLpro inhibitors: Identification of ML300 and noncovalent nanomolar inhibitors with an induced-fit binding Bioorganic & Medicinal Chemistry Letters  2013 23:6172-6177  DOI:10.1016/j.bmcl.2013.08.112  PMID:24080461  PMCID:PMC3878165
    • Richard, D. J., Lena, R., Bannister, T., Blake, N., Pierceall, W. E., Carlson, N. E., Keller, C. E., Koenig, M., He, Y., Minond, D., Mishra, J., Cameron, M., et al. Hydroxyquinoline-derived compounds and analoguing of selective Mcl-1 inhibitors using a functional biomarker Bioorganic & Medicinal Chemistry  2013 21:6642-6649  DOI:10.1016/j.bmc.2013.08.017  PMID:23993674  PMCID:PMC3831274
    • Satsu, H., Schaeffer, M. T., Guerrero, M., Saldana, A., Eberhart, C., Hodder, P., Cayanan, C., Schurer, S., Bhhatarai, B., Roberts, E., Rosen, H., Brown, S. J. A sphingosine 1-phosphate receptor 2 selective allosteric agonist Bioorganic & Medicinal Chemistry  2013 21:5373-5382  DOI:10.1016/j.bmc.2013.06.012  PMID:23849205  PMCID:PMC3786410
    • Conn, P. M., Smith, E., Hodder, P., Janovick, J. A., Smithson, D. C. High-throughput screen for pharmacoperones of the vasopressin type 2 receptor Journal of Biomolecular Screening  2013 18:930-937  DOI:10.1177/1087057113483559  PMID:23640875  PMCID:PMC3735853
    • Thomas, P. W., Spicer, T., Cammarata, M., Brodbelt, J. S., Hodder, P., Fast, W. An altered zinc-binding site confers resistance to a covalent inactivator of New Delhi metallo-beta-lactamase-1 (NDM-1) discovered by high-throughput screening Bioorganic & Medicinal Chemistry  2013 21:3138-3146  DOI:10.1016/j.bmc.2013.03.031  PMID:23591260  PMCID:PMC3651783
    • Gentry, P. R., Bridges, T. M., Lamsal, A., Vinson, P. N., Smith, E., Chase, P., Hodder, P. S., Engers, J. L., Niswender, C. M., Daniels, J. S., Conn, P. J., Wood, M. R., et al. Discovery of ML326: The first sub-micromolar, selective M-5 PAM Bioorganic & Medicinal Chemistry Letters  2013 23:2996-3000  DOI:10.1016/j.bmcl.2013.03.032  PMID:23562060  PMCID:PMC3634896
    • Karapetyan, Y. E., Sferrazza, G. F., Zhou, M., Ottenberg, G., Spicer, T., Chase, P., Fallahi, M., Hodder, P., Weissmann, C., Lasmezas, C. I. Unique drug screening approach for prion diseases identifies tacrolimus and astemizole as antiprion agents Proceedings of the National Academy of Sciences of the United States of America  2013 110:7044-7049  DOI:10.1073/pnas.1303510110  PMID:23576755  PMCID:PMC3637718
    • Qin, Q., Knapinska, A., Dobri, N., Madoux, F., Chase, P., Hodder, P., Petrukhin, K. In pursuit of synthetic modulators for the orphan retina-specific nuclear receptor NR2E3 Journal of Ocular Pharmacology and Therapeutics  2013 29:298-309  DOI:10.1089/jop.2012.0135  PMID:23098562  PMCID:PMC3613967
    • Nagano, J. M. G., Hsu, K. L., Whitby, L. R., Niphakis, M. J., Speers, A. E., Brown, S. J., Spicer, T., Fernandez-Vega, V., Ferguson, J., Hodder, P., Srinivasan, P., Gonzalez, T. D., et al. Selective inhibitors and tailored activity probes for lipoprotein-associated phospholipase A(2) Bioorganic & Medicinal Chemistry Letters  2013 23:839-843  DOI:10.1016/j.bmcl.2012.11.061  PMID:23260346  PMCID:PMC3549684
    • Jacobs, J., Grum-Tokars, V., Zhou, Y., Turlington, M., Saldanha, S. A., Chase, P., Eggler, A., Dawson, E. S., Baez-Santos, Y. M., Tomar, S., Mielech, A. M., Baker, S. C., et al. Discovery, synthesis, and structure-based optimization of a series of n-(tert-butyl)-2-(n-arylamido)-2-(pyridin-3-yl) acetamides (ml188) as potent noncovalent small molecule inhibitors of the severe acute respiratory syndrome coronavirus (sars-cov) 3cl protease Journal of Medicinal Chemistry  2013 56:534-546  DOI:10.1021/jm301580n  PMID:23231439  PMCID:PMC3569073
    • Gomes, I., Fujita, W., Gupta, A., Saldanha, A. S., Negri, A., Pinello, C. E., Roberts, E., Filizola, M., Hodder, P., Devi, L. A. Identification of a μ-δ opioid receptor heteromer-biased agonist with antinociceptive activity Proceedings of the National Academy of Sciences of the United States of America  2013 110:12072-12077  DOI:10.1073/pnas.1222044110  PMID:23818586  PMCID:PMC3718106
    • Yang, H., Pinello, C. E., Luo, J., Li, D., Wang, Y., Zhao, L. Y., Jahn, S. C., Saldanha, S. A., Planck, J., Geary, K. R., Ma, H., Law, B. K., et al. Small-molecule inhibitors of acetyltransferase p300 identified by high-throughput screening are potent anticancer agents Molecular Cancer Therapeutics  2013 12:610-620  DOI:10.1158/1535-7163.mct-12-0930  PMID:23625935  PMCID:PMC3651759
    • Urbano, M., Guerrero, M., Zhao, J., Velaparthi, S., Saldanha, S. A., Chase, P., Wang, Z. W., Civelli, O., Hodder, P., Schaeffer, M. T., Brown, S., Rosen, H., et al. Design, synthesis and SAR analysis of novel potent and selective small molecule antagonists of NPBWR1 (GPR7) Bioorganic & Medicinal Chemistry Letters  2012 22:7135-7141  DOI:10.1016/j.bmcl.2012.09.074  PMID:23079522  PMCID:PMC3601546
    • Adibekian, A., Martin, B. R., Chang, J. W., Hsu, K. L., Tsuboi, K., Bachovchin, D. A., Speers, A. E., Brown, S. J., Spicer, T., Fernandez-Vega, V., Ferguson, J., Hodder, P. S., et al. Confirming target engagement for reversible inhibitors in vivo by kinetically tuned activity-based probes Journal of the American Chemical Society  2012 134:10345-10348  DOI:10.1021/ja303400u  PMID:22690931  PMCID:PMC3392194
    • Amundsen, S. K., Spicer, T., Karabulut, A. C., Londono, L. M., Eberhart, C., Vega, V. F., Bannister, T. D., Hodder, P., Smith, G. R. Small-molecule inhibitors of bacterial AddAB and RecBCD helicase-nuclease DNA repair enzymes ACS Chemical Biology  2012 7:879-891  DOI:10.1021/cb300018x  PMID:22443934  PMCID:PMC3356449
    • Calamini, B., Silva, M. C., Madoux, F., Hutt, D. M., Khanna, S., Chalfant, M. A., Saldanha, S. A., Hodder, P., Tait, B. D., Garza, D., Balch, W. E., Morimoto, R. I. Small-molecule proteostasis regulators for protein conformational diseases Nature Chemical Biology  2012 8:185-196  DOI:10.1038/nchembio.763  PMID:22198733  PMCID:PMC3262058
    • Guerrero, M., Urbano, M., Zhao, J., Crisp, M., Chase, P., Hodder, P., Schaeffer, M. T., Brown, S., Rosen, H., Roberts, E. Discovery, design and synthesis of novel potent and selective sphingosine-1-phosphate 4 receptor (s1p(4)-r) agonists Bioorganic & Medicinal Chemistry Letters  2012 22:537-542  DOI:10.1016/j.bmcl.2011.10.096  PMID:22119461  PMCID:PMC3248976
    • Peatey, C. L., Spicer, T. P., Hodder, P. S., Trenholme, K. R., Gardiner, D. L. A high-throughput assay for the identification of drugs against late-stage Plasmodium falciparum gametocytes Molecular and Biochemical Parasitology  2011 180:127-131  DOI:10.1016/j.molbiopara.2011.09.002  PMID:21939693
    • Roth, J., Minond, D., Darout, E., Liu, Q., Lauer, J., Hodder, P., Fields, G. B., Roush, W. R. Identification of novel, exosite-binding matrix metalloproteinase-13 inhibitor scaffolds Bioorganic & Medicinal Chemistry Letters  2011 21:7180-7184  DOI:10.1016/j.bmcl.2011.09.077  PMID:22018790  PMCID:PMC3210410
    • Bialkowska, A. B., Crisp, M., Bannister, T., He, Y. J., Chowdhury, S., Schurer, S., Chase, P., Spicer, T., Madoux, F., Tian, C. L., Hodder, P., Zaharevitz, D., et al. Identification of small-molecule inhibitors of the colorectal cancer oncogene Kruppel-like factor 5 expression by ultrahigh-throughput screening Molecular Cancer Therapeutics  2011 10:2043-2051  DOI:10.1158/1535-7163.mct-11-0550  PMID:21885866  PMCID:PMC3213326
    • Tsuboi, K., Bachovchin, D. A., Speers, A. E., Spicer, T. P., Fernandez-Vega, V., Hodder, P., Rosen, H., Cravatt, B. F. Potent and selective inhibitors of glutathione S-transferase omega 1 that impair cancer drug resistance Journal of the American Chemical Society  2011 133:16605-16616  DOI:10.1021/ja2066972  PMID:21899313  PMCID:PMC3226709
    • Lone, A. M., Bachovchin, D. A., Westwood, D. B., Speers, A. E., Spicer, T. P., Fernandez-Vega, V., Chase, P., Hodder, P. S., Rosen, H., Cravatt, B. F., Saghatelian, A. A substrate-free activity-based protein profiling screen for the discovery of selective PREPL inhibitors Journal of the American Chemical Society  2011 133:11665-11674  DOI:10.1021/ja2036095  PMID:21692504  PMCID:PMC3145007
    • Baillargeon, P., Scampavia, L., Einsteder, R., Hodder, P. Monitoring of HTS compound library quality via a high-resolution image acquisition and processing instrument JALA  2011 16:197-203  DOI:10.1016/j.jala.2011.02.004  PMID:21609702  PMCID:PMC3417353
    • Bachovchin, D. A., Mohr, J. T., Speers, A. E., Wang, C., Berlin, J. M., Spicer, T. P., Fernandez-Vega, V., Chase, P., Hodder, P. S., Schurer, S. C., Nomura, D. K., Rosen, H., et al. Academic cross-fertilization by public screening yields a remarkable class of protein phosphatase methylesterase-1 inhibitors Proceedings of the National Academy of Sciences of the United States of America  2011 108:6811-6816  DOI:10.1073/pnas.1015248108  PMID:21398589  PMCID:PMC3084096
    • Chou, T. F., Brown, S. J., Minond, D., Nordin, B. E., Li, K. L., Jones, A. C., Chase, P., Porubsky, P. R., Stoltz, B. M., Schoenen, F. J., Patricelli, M. P., Hodder, P., et al. Reversible inhibitor of p97, dbeq, impairs both ubiquitin-dependent and autophagic protein clearance pathways Proceedings of the National Academy of Sciences of the United States of America  2011 108:4834-4839  DOI:10.1073/pnas.1015312108  PMID:21383145  PMCID:PMC3064330
    • Istrate, M. A., Spicer, T. P., Wang, Y., Bernard, J. A., Helvering, L. M., Bocchinfuso, W. P., Richardson, T. I., Zink, R., Kumar, N., Montrose-Rafizadeh, C., Dodge, J., Hodder, P., et al. Development of an HTS-compatible assay for discovery of ROR alpha modulators using AlphaScreen (r) technology Journal of Biomolecular Screening  2011 16:183-191  DOI:10.1177/1087057110389040  PMID:21297105  PMCID:PMC4434603
    • Urbano, M., Guerrero, M., Velaparthi, S., Crisp, M., Chase, P., Hodder, P., Schaeffer, M. T., Brown, S., Rosen, H., Roberts, E. Discovery, synthesis and sar analysis of novel selective small molecule s1p(4)-r agonists based on a (2z,5z)-5-((pyrrol-3-yl)methylene)-3-alkyl-2-(alkylimino)thiazolidin-4-o ne chemotype Bioorganic & Medicinal Chemistry Letters  2011 21:6739-6745  DOI:10.1016/j.bmcl.2011.09.049  PMID:21982495  PMCID:PMC3209756
    • Brunell, D., Weissbach, H., Hodder, P., Brot, N. A high-throughput screening compatible assay for activators and inhibitors of methionine sulfoxide reductase a Assay and Drug Development Technologies  2010 8:615-620  DOI:10.1089/adt.2009.0263  PMID:20515413  PMCID:PMC2978062
    • Madoux, F., Simanski, S., Chase, P., Mishra, J. K., Roush, W. R., Ayad, N. G., Hodder, P. An ultra-high throughput cell-based screen for wee1 degradation inhibitors Journal of Biomolecular Screening  2010 15:907-917  DOI:10.1177/1087057110375848  PMID:20660794  PMCID:PMC3082437
    • Weide, T., Saldanha, S. A., Minond, D., Spicer, T. P., Fotsing, J. R., Spaargaren, M., Frere, J. M., Bebrone, C., Sharpless, K. B., Hodder, P. S., Fokin, V. V. NH-1,2,3-triazole-based inhibitors of the VIM-2 Metallo-beta-Lactamase: synthesis and structure-activity studies ACS Medicinal Chemistry Letters  2010 1:150-154  DOI:10.1021/ml900022q  PMID:20625539  PMCID:PMC2901175
    • Bachovchin, D. A., Wolfe, M. R., Masuda, K., Brown, S. J., Spicer, T. P., Fernandez-Vega, V., Chase, P., Hodder, P. S., Rosen, H., Cravatt, B. F. Oxime esters as selective, covalent inhibitors of the serine hydrolase retinoblastoma-binding protein 9 (RBBP9) Bioorganic & Medicinal Chemistry Letters  2010 20:2254-2258  DOI:10.1016/j.bmcl.2010.02.011  PMID:20207142  PMCID:PMC2843764
    • Grimm, C., Jors, S., Saldanha, S. A., Obukhov, A. G., Pan, B. F., Oshima, K., Cuajungco, M. P., Chase, P., Hodder, P., Heller, S. Small molecule activators of TRPML3 Chemistry & Biology  2010 17:135-148  DOI:10.1016/j.chembiol.2009.12.016  PMID:20189104  PMCID:PMC2834294
    • Kota, S., Scampavia, L., Spicer, T., Beeler, A. B., Takahashi, V., Snyder, J. K., Porco, J. A., Hodder, P., Strosberg, A. D. A time-resolved fluorescence-resonance energy transfer assay for identifying inhibitors of hepatitis C virus core dimerization Assay and Drug Development Technologies  2010 8:96-105  DOI:10.1089/adt.2009.0217  PMID:20035614  PMCID:PMC2971647
    • Tanaka, K., Koresawa, M., Iida, M., Fukasawa, K., Stec, E., Cassaday, J., Chase, P., Rickert, K., Hodder, P., Takagi, T., Komatani, H. Multiplexed random peptide library and phospho-specific antibodies facilitate human polo-like kinase 1 inhibitor screen Assay and Drug Development Technologies  2010 8:47-62  DOI:10.1089/adt.2009.0212  PMID:20085455  PMCID:PMC3532019
    • Brothers, S. P., Saldanha, S. A., Spicer, T. P., Cameron, M., Mercer, B. A., Chase, P., McDonald, P., Wahlestedt, C., Hodder, P. S. Selective and brain penetrant neuropeptide y y2 receptor antagonists discovered by whole-cell high-throughput screening Molecular Pharmacology  2010 77:46-57  DOI:10.1124/mol.109.058677  PMID:19837904  PMCID:PMC2802430
    • Minond, D., Saldanha, S. A., Subramaniam, P., Spaargaren, M., Spicer, T., Fotsing, J. R., Weide, T., Fokin, V. V., Sharpless, K. B., Galleni, M., Bebrone, C., Lassaux, P., et al. Inhibitors of VIM-2 by screening pharmacologically active and click-chemistry compound libraries Bioorganic & Medicinal Chemistry  2009 17:5027-5037  DOI:10.1016/j.bmc.2009.05.070  PMID:19553129  PMCID:PMC2759276
    • Doghman, M., Cazareth, J., Douguet, D., Madoux, F., Hodder, P., Lalli, E. Inhibition of adrenocortical carcinoma cell proliferation by steroidogenic factor-1 inverse agonists Journal of Clinical Endocrinology & Metabolism  2009 94:2178-2183  DOI:10.1210/jc.2008-2163  PMID:19318454  PMCID:PMC2690427
    • Lauer-Fields, J. L., Minond, D., Chase, P. S., Baillargeon, P. E., Saldanha, S. A., Stawikowska, R., Hodder, P., Fields, G. B. High throughput screening of potentially selective mmp-13 exosite inhibitors utilizing a triple-helical fret substrate Bioorganic & Medicinal Chemistry  2009 17:990-1005  DOI:10.1016/j.bmc.2008.03.004  PMID:18358729  PMCID:PMC3298815
    • Schurer, S. C., Brown, S. J., Gonzalez-Cabrera, P. J., Schaeffer, M. T., Chapman, J., Jo, E., Chase, P., Spicer, T., Hodder, P., Rosen, H. Ligand-binding pocket shape differences between sphingosine 1-phosphate (S1P) receptors S1P1 and S1P3 determine efficiency of chemical probe identification by ultrahigh-throughput screening ACS Chemical Biology  2008 3:486-498  DOI:10.1021/cb800051m  PMID:18590333  PMCID:PMC2597349
    • Chung, C. C., Ohwaki, K., Schneeweis, J. E., Stec, E., Varnerin, J. P., Goudreau, P. N., Chang, A., Cassaday, J., Yang, L. H., Yamakawa, T., Kornienko, O., Hodder, P., et al. A fluorescence-based thiol quantification assay for ultra-high-throughput screening for inhibitors of coenzyme a production Assay and Drug Development Technologies  2008 6:361-374  DOI:10.1089/adt.2007.105  PMID:18452391
    • Madoux, F., Li, X. L., Chase, P., Zastrow, G., Cameron, M. D., Conkright, J. J., Griffin, P. R., Thacher, S., Hodder, P. Potent, selective and cell penetrant inhibitors of SF-1 by functional ultra-high-throughput screening Molecular Pharmacology  2008 73:1776-1784  DOI:10.1124/mol.108.045963  PMID:18334597  PMCID:PMC3228235
    • Roth, J., Madoux, F., Hodder, P., Roush, W. R. Synthesis of small molecule inhibitors of the orphan nuclear receptor steroidogenic factor-1 (NR5A1) based on isoquinolinone scaffolds Bioorganic & Medicinal Chemistry Letters  2008 18:2628-2632  DOI:10.1016/j.bmcl.2008.03.027  PMID:18374567  PMCID:PMC2592603
    • Lauer-Fields, J. L., Spicer, T. P., Chase, P. S., Cudic, M., Burstein, G. D., Nagase, H., Hodder, P., Fields, G. B. Screening of potential a, disintegrin and metalloproteinase with thrombospondin motifs-4 inhibitors using a collagen model fluorescence resonance energy transfer substrate Analytical Biochemistry  2008 373:43-51  DOI:10.1016/j.ab.2007.09.014  PMID:17949675  PMCID:PMC2245870
    • Schroeter, T., Minond, D., Weiser, A., Dao, C., Habel, J., Spicer, T., Chase, P., Baillargeon, P., Scampavia, L., Schuerer, S., Chung, C., Mader, C., et al. Comparison of miniaturized time-resolved fluorescence resonance energy transfer and enzyme-coupled luciferase high-throughput screening assays to discover inhibitors of Rho-kinase II (ROCK-II) Journal of Biomolecular Screening  2008 13:17-28  DOI:10.1177/1087057107310806  PMID:18227223
    • Zuck, P., O'Donnell, G. T., Cassaday, J., Chase, P., Hodder, P., Strulovici, B., Ferrer, M. Miniaturization of absorbance assays using the fluorescent properties of white microplates Analytical Biochemistry  2005 342:254-259  DOI:10.1016/j.ab.2005.04.029  PMID:15949786
    • Hale, J. J., Lynch, C. L., Neway, W., Mills, S. G., Hajdu, R., Keohane, C. A., Rosenbach, M. J., Milligan, J. A., Shei, G. J., Parent, S. A., Chrebet, G., Bergstrom, J., et al. A rational utilization of high-throughput screening affords selective, orally bioavailable 1-benzyl-3-carboxyazetidine sphingosine-1-phosphate-1 receptor agonists Journal of Medicinal Chemistry  2004 47:6662-6665  DOI:10.1021/jm0492507  PMID:15615513
    • Hodder, P., Mull, R., Cassaday, J., Berry, K., Strulovici, B. Miniaturization of intracellular calcium functional assays to 1536-well plate format using a fluorometric imaging plate reader Journal of Biomolecular Screening  2004 9:417-426  DOI:10.1177/1087057104264038  PMID:15296641
    • Kunapuli, P., Ransom, R., Murphy, K. L., Pettibone, D., Kerby, J., Grimwood, S., Zuck, P., Hodder, P., Lacson, R., Hoffman, I., Inglese, J., Strulovici, B. Development of an intact cell reporter gene beta-lactamase assay for g protein-coupled receptors for high-throughput screening Analytical Biochemistry  2003 314:16-29  DOI:10.1016/s0003-2697(02)00587-0  PMID:12633598
    • Hodder, P., Cassaday, J., Peltier, R., Berry, K., Inglese, J., Feuston, B., Culberson, C., Bleicher, L., Cosford, N. D. P., Bayly, C., Suto, C., Varney, M., et al. Identification of metabotropic glutamate receptor antagonists using an automated high-throughput screening system Analytical Biochemistry  2003 313:246-254  DOI:10.1016/s0003-2697(02)00608-5  PMID:12605861
    • Hodder, P. S., Beeson, C., Ruzicka, J. Equilibrium and kinetic measurements of muscarinic receptor antagonism on living cells using bead injection spectroscopy Analytical Chemistry  2000 72:3109-3115  DOI:10.1021/ac991231v  PMID:10939374
    • Scampavia, L. D., Hodder, P. S., Lahdesmaki, I., Ruzicka, J. Automation of functional assays by flow injection fluorescence microscopy Trends in Biotechnology  1999 17:443-447  DOI:10.1016/s0167-7799(99)01375-x  PMID:10511702
    • Hodder, P. S., Ruzicka, J. A flow injection renewable surface technique for cell-based drug discovery functional assays Analytical Chemistry  1999 71:1160-1166  DOI:10.1021/ac981102z  PMID:10093496
    • Hodder, P. S., Blankenstein, G., Ruzicka, J. Microfabricated flow chamber for fluorescence-based chemistries and stopped-flow injection cytometry Analyst  1997 122:883-887  DOI:10.1039/a701750b  PMID:9374023
  • report

    • Calamini, B., Silva, M. C., Madoux, F., Hutt, D. M., Khanna, S., Chalfant, M. A., Allais, C., Ouizem, S., Saldanha, S. A., Ferguson, J., Mercer, B. A., Michael, C., et al. ML346: A novel modulator of proteostasis for protein conformational diseases 2010
    • Minond, D., Saldanha, S. A., Spicer, T., Qin, L., Mercer, B. A., Roush, W. R., Hodder, P. HTS assay for discovery of novel metallo-beta-lactamase (MBL) inhibitors Probe Reports from the NIH Molecular Libraries Program. 2010  PMID:21961119
    • Hulce, J. J., Joslyn, C., Speers, A. E., Brown, S. J., Spicer, T., Fernandez-Vega, V., Ferguson, J., Cravatt, B. F., Hodder, P., Rosen, H. An in vivo active carbamate-based dual inhibitor of lysophospholipase 1 (LYPLA1) and lysophospholipase 2 (LYPLA2) Probe Reports from the NIH Molecular Libraries Program. 2010  PMID:25506974
    • Zuhl, A. M., Mohr, J. T., Speers, A. E., Bachovchin, D. A., Berlin, J. M., Spicer, T., Fernandez-Vega, V., Brown, S. J., Ferguson, J., Fu, G. C., Cravatt, B. F., Hodder, P., et al. Probe development efforts to identify novel inhibitors of ABHD10 Probe Reports from the NIH Molecular Libraries Program. 2010  PMID:23762952
    • Busby, S., Nuhant, P., Cameron, M., Mercer, B. A., Hodder, P., Roush, W. R., Griffin, P. R. Discovery of inverse agonists for the liver receptor homologue-1 (LRH1; NR5A2) 2010
    • Kumar, N., Nuhant, P., Solt, L. A., Conkright, J. J., Wang, Y., Istrate, M. A., Busby, S. A., Ruben, D. G. O., Burris, T. P., Cameron, M., Mercer, B. A., Hodder, P., et al. Identification of a novel selective inverse agonist probe and analogs for the Retinoic acid receptor-related Orphan Receptor Alpha (RORalpha) 2010
    • Kumar, N., Kamenecka, T., Lyda, B., Khan, P., Chang, M. R., Garcia-Ordonez, R. D., Cameron, M., Ferguson, J., Mercer, B. A., Hodder, P., Rosen, H., Griffin, P. R. Identification of a novel selective inverse agonist probe and analogs for the Retinoic acid receptor-related Orphan Receptor Gamma (RORgamma) 2010
    • Simanski, S., Madoux, F., Rahaim, R. J., Chase, P., Schurer, S., Cameron, M., Mercer, B. A., Hodder, P., Roush, W. R., Ayad, N. G. Identification of small molecule inhibitors of Wee1 degradation and mitotic entry 2010
    • Kota, S., Madoux, F., Chase, P., Takahashi, V., Liu, Q., Mercer, B. A., Cameron, M., Strosberg, A. D., Roush, W., Hodder, P. ML322, a small molecule inhibitor of dimerization of the core protein of hepatitis C virus (HCV) 2010
    • Cameron, M., Kamenecka, T., Madoux, F., Chase, P., Roush, W., Hodder, P., Griffin, P. R. ML368 identification of imidazopyridines as selective inhibitors of the cytochrome P450 enzyme CYP3A4 2010
    • Kamenecka, T. M., Busby, S. A., Kumar, N., Choi, J. H., Banks, A. S., Vidovic, D., Cameron, M. D., Schurer, S. C., Mercer, B. A., Hodder, P., Spiegelman, B. M., Griffin, P. R. Potent anti-diabetic actions of a novel non-agonist PPARγ ligand that blocks Cdk5-mediated phosphorylation 2010
    • Adibekian, A., Martin, B. R., Chang, J. W., Hsu, K. L., Tsuboi, K., Bachovchin, D. A., Speers, A. E., Brown, S. J., Spicer, T., Fernandez-Vega, V., Ferguson, J., Cravatt, B. F., et al. Characterization of a Selective, Reversible Inhibitor of Lysophospholipase 2 (LYPLA2) Probe Reports from the NIH Molecular Libraries Program. 2010  PMID:24624468
    • Adibekian, A., Martin, B. R., Chang, J. W., Hsu, K. L., Tsuboi, K., Bachovchin, D. A., Speers, A. E., Brown, S. J., Spicer, T., Fernandez-Vega, V., Ferguson, J., Cravatt, B. F., et al. Characterization of a selective, reversible inhibitor of lysophospholipase 1 (LYPLA1) Probe Reports from the NIH Molecular Libraries Program. 2010  PMID:24624465
    • Schoenen, F. J., Whipple, D., Baillargeon, P., Brown, C. L., Chase, P., Ferguson, J., Fernandez-Vega, V., Hodder, P., Mathew, R., Neuenswander, B., Porubsky, P., Rogers, S., et al. Inhibitors of the Plasmodium falciparum M17 leucine aminopeptidase Probe Reports from the NIH Molecular Libraries Program. 2010  PMID:25506973
    • Schoenen, F. J., Weiner, W. S., Baillargeon, P., Brown, C. L., Chase, P., Ferguson, J., Fernandez-Vega, V., Ghosh, P., Hodder, P., Krise, J. P., Matharu, D. S., Neuenswander, B., et al. Inhibitors of the Plasmodium falciparum M18 aspartyl aminopeptidase Probe Reports from the NIH Molecular Libraries Program. 2010  PMID:24479194
    • Bialkowska, A., Crisp, M., Madoux, F., Spicer, T., Knapinska, A., Mercer, B., Bannister, T. D., He, Y., Chowdhury, S., Cameron, M., Yang, V. W., Hodder, P. ML264: An antitumor agent that potently and selectively inhibits kruppel-like factor five (KLF5) expression: a probe for studying colon cancer development and progression Probe Reports from the NIH Molecular Libraries Program. 2010  PMID:23762940
    • Spicer, T., Minond, D., Enogieru, I., Saldanha, S. A., Allais, C., Liu, Q., Mercer, B. A., Roush, W. R., Hodder, P. ML302, a novel beta-lactamase (BLA) inhibitor Probe Reports from the NIH Molecular Libraries Program. 2010  PMID:23762954
    • Bannister, T., Koenig, M., He, Y., Mishra, J., Spicer, T., Minond, D., Saldanha, A., Mercer, B. A., Cameron, M., Lena, R., Carlson, N., Richard, D., et al. ML311: A small molecule that potently and selectively disrupts the protein-protein interaction of Mcl-1 and Bim: a probe for studying lymphoid tumorigenesis Probe Reports from the NIH Molecular Libraries Program. 2010  PMID:23762927
    • Bannister, T. D., Nair, R., Spicer, T., Fernandez Vega, V., Eberhart, C., Mercer, B. A., Cameron, M., Schurer, S., Amundsen, S. K., Karabulut, A., Londono, L. M., Smith, G. R., et al. ML328: A novel dual inhibitor of bacterial AddAB and RecBCD helicase-nuclease DNA repair enzymes Probe Reports from the NIH Molecular Libraries Program. 2010  PMID:23833795
    • Nagano, J. M. G., Hsu, K. L., Speers, A. E., Brown, S. J., Spicer, T., Fernandez-Vega, V., Ferguson, J., Bahnson, B. J., Cravatt, B. F., Hodder, P., Rosen, H. Optimization and characterization of a carbamate inhibitor for plasma platelet-activating factor acetylhydrolase (pPAFAH) Probe Reports from the NIH Molecular Libraries Program. 2010  PMID:23658952
    • Dreyton, C. J., Jones, J. E., Knuckley, B. A., Subramanian, V., Anderson, E. D., Brown, S. J., Fernandez-Vega, V., Eberhart, C., Spicer, T., Zuhl, A. M., Ferguson, J., Speers, A. E., et al. Optimization and characterization of a pan protein arginine deiminase (PAD) inhibitor Probe Reports from the NIH Molecular Libraries Program. 2010  PMID:23833800
    • Adibekian, A., Martin, B. R., Speers, A. E., Brown, S. J., Spicer, T., Fernandez-Vega, V., Ferguson, J., Cravatt, B. F., Hodder, P., Rosen, H. Optimization and characterization of a triazole urea dual inhibitor for lysophospholipase 1 (LYPLA1) and lysophospholipase 2 (LYPLA2) Probe Reports from the NIH Molecular Libraries Program. 2010  PMID:23658947
    • Adibekian, A., Hsu, K. L., Speers, A. E., Brown, S. J., Spicer, T., Fernandez-Vega, V., Ferguson, J., Cravatt, B. F., Hodder, P., Rosen, H. Optimization and characterization of a triazole urea inhibitor for alpha/beta hydrolase domain-containing protein 11 (ABHD11): anti-probe for LYPLA1/LYPLA2 dual inhibitor ML211 Probe Reports from the NIH Molecular Libraries Program. 2010  PMID:23658953
    • Hsu, K. L., Tsuboi, K., Speers, A. E., Brown, S. J., Spicer, T., Fernandez-Vega, V., Ferguson, J., Cravatt, B. F., Hodder, P., Rosen, H. Optimization and characterization of a triazole urea inhibitor for diacylglycerol lipase beta (DAGL-beta) Probe Reports from the NIH Molecular Libraries Program. 2010  PMID:23658950
    • Adibekian, A., Hsu, K. L., Speers, A. E., Monillas, E. S., Brown, S. J., Spicer, T., Fernandez-Vega, V., Ferguson, J., Bahnson, B. J., Cravatt, B. F., Hodder, P., Rosen, H. Optimization and characterization of a triazole urea inhibitor for platelet-activating factor acetylhydrolase type 2 (PAFAH2) Probe Reports from the NIH Molecular Libraries Program. 2010  PMID:23658960
    • Tsuboi, K., Bachovchin, D. A., Speers, A. E., Brown, S. J., Spicer, T., Fernandez-Vega, V., Ferguson, J., Cravatt, B. F., Hodder, P., Rosen, H. Optimization and characterization of an inhibitor for glutathione S-tranferase omega 1 (GSTO1) Probe Reports from the NIH Molecular Libraries Program. 2010  PMID:22834034
    • Hsu, K. L., Tsuboi, K., Speers, A. E., Brown, S. J., Spicer, T., Fernandez-Vega, V., Ferguson, J., Cravatt, B. F., Hodder, P., Rosen, H. Optimization and characterization of triazole urea inhibitors for abhydrolase domain containing protein 6 (ABHD6) Probe Reports from the NIH Molecular Libraries Program. 2010  PMID:23762934
    • Guerrero, M., Poddutoori, R., Pinacho-Crisostomo, F., Schaeffer, M. T., Brown, S. J., Spicer, T., Chase, P., Ferguson, J., Roberts, E., Sanna, G., Hodder, P., Rosen, H. Probe development efforts for an allosteric agonist of the sphingosine 1-phosphate receptor 3 (S1P3) Probe Reports from the NIH Molecular Libraries Program. 2010  PMID:23658964
    • Bachovchin, D. A., Speers, A. E., Brown, S. J., Spicer, T. P., Fernandez, Vega, Ferguson, J., Mohr, J. T., Murphy, J., Fu, G. C., Cravatt, B. F., Hodder, P. S., Rosen, H. Probe development efforts to identify novel inhibitors of protein phosphatase methylesterase-1 (PME-1) Probe Reports from the NIH Molecular Libraries Program. 2010  PMID:22834039
    • Saldanha, S. A., Brothers, S. P., Spicer, T., Cameron, M., Mercer, B. A., Chase, P., McDonald, P., Wahlestedt, C., Hodder, P. S. Probe report for NPY-Y2 receptor antagonists Probe Reports from the NIH Molecular Libraries Program. 2010  PMID:21433370
    • Bachovchin, D. A., Speers, A. E., Zuhl, A. M., Brown, S. J., Cravatt, B. F., Fernandez, Vega, Spicer, T., Mercer, B. A., Ferguson, J., Hodder, P., Rosen, H. R. Probe report for PME-1 inhibitors Probe Reports from the NIH Molecular Libraries Program. 2010  PMID:21433379
    • Brown, S. J., Bachovchin, D. A., Cravatt, B. F., Fernandez-Vega, V., Spicer, T., Mercer, B. A., Hodder, P., Rosen, H. R. Probe report for RBBP9 inhibitors - Probe 1 Probe Reports from the NIH Molecular Libraries Program. 2010  PMID:21433353
    • Bachovchin, D. A., Speers, A. E., Brown, S. J., Cravatt, B. F., Spicer, T., Mercer, B. A., Ferguson, J., Hodder, P., Rosen, H. R. Probe report for RBBP9 inhibitors - Probe 2 Probe Reports from the NIH Molecular Libraries Program. 2010  PMID:21433382

featured in

  • Scripps Research Institute Scientists Develop Promising Drug Candidates for Pain, Addiction  News Release
  • Scripps Research Scientist Wins Pair of Grants to Study Critical Component of Memory  News Release
scroll to property group menus

Affiliation

head of

  • Molecular Screening Center Director 2005 -
scroll to property group menus

Research

research overview

  • The Hodder laboratory, in collaboration with other scientists at Scripps and around the world, identifies “lead” compounds that can help better understand and ultimately cure diseases such as cancer, diabetes, Alzheimer's and hepatitis. By combining robotics, biology, chemistry and informatics, we are able to perform High-Throughput Screening, a robotic process employing sophisticated automation, detection and assay technologies that tests hundreds of thousands of drug-like compounds for biological activity both rapidly and economically. In addition we have the personnel and facilities to engage both pre- and post-HTS activities, including HTS assay development, cheminformatics, compound synthesis/procurement, compound QC (via LC-MS) and mechanism of action/profiling studies. We work with mammalian, yeast and bacterial targets. Our expertise can be accessed through collaborative mechanisms, such as the NIH’s Molecular Libraries initiative (http://mlpcn.florida.scripps.edu/). In other efforts, we research and develop novel automation, instrumentation and assay technologies that benefit the HTS disciplines. We are also engaged in developing novel probes and therapeutics relevant to infectious disease research.
scroll to property group menus

Background

education and training

  • Ph.D. in Chemistry 1999
  • B.S. in Chemistry, University of California, San Diego 1994
scroll to property group menus

Contact

full name

  • Peter Hodder

©2021 The Scripps Research Institute | Terms of Use | Powered by VIVO

  • About
  • Contact Us
  • Support