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Havran, Wendy
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Havran, Wendy

Faculty Member
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Positions

  • Professor Adjunct, Department of Medicine, School of Medicine, University of California, San Diego
  • 2017 - 2020 Professor, Immunology and Microbiology , Scripps Research
  • 1991 - 2020 Faculty Member, Skaggs Graduate School of Chemical and Biological Sciences , Scripps Research
  • 1991 - 2016 Professor, Immunology and Microbial Science (IMS) , Scripps Research
Dr. Wendy Havran studies a unique subset of T lymphocytes, called "gamma-delta" T cells, which reside in epithelial tissues, are derived from fetal precursors, express a tissue-specific, invariant antigen receptor, and are involved in tissue repair as well as epithelial inflammatory diseases such as asthma and ulcerative colitis.

Research Areas research areas

  • Cancer (UMLS)

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  • Havran Laboratory
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Publications

recent publications

  • academic article

    • Soley, B. D., Silva, L. M., Mendes, Dagb, Bafica, A., Pesquero, J. B., Bader, M., Witherden, D. A., Havran, W. L., Calixto, J. B., Otuki, M. F., Cabrini, D. A. B-1 and B-2 kinin receptor blockade improves psoriasis-like disease British Journal of Pharmacology  2020  DOI:10.1111/bph.15077  PMID:32335893
    • Johnson, M. D., Witherden, D. A., Havran, W. L. The Role of Tissue-resident γδ T Cells in Stress Surveillance and Tissue Maintenance Cells  2020 9  DOI:10.3390/cells9030686  PMID:32168884  PMCID:PMC7140644
    • McGraw, J., Havran, W. L. γδ T cells and IgE team up to prevent tumors Nature Immunology  2018 19:793-795  DOI:10.1038/s41590-018-0167-2  PMID:30013144
    • Havran, W. L. Specialized antitumor functions for Skin γδ T cells Journal of Immunology  2018 200:3029-3030  DOI:10.4049/jimmunol.1800356  PMID:29685948
    • Witherden, D. A., Johnson, M. D., Havran, W. L. Coreceptors and their ligands in epithelial γδ T cell Bbology Frontiers in Immunology  2018 9  DOI:10.3389/fimmu.2018.00731  PMID:29686687  PMCID:PMC5900413
    • Lee, P., Gund, R., Dutta, A., Pincha, N., Rana, I., Ghosh, S., Witherden, D., Kandyba, E., MacLeod, A., Kobielak, K., Havran, W. L., Jamora, C. Stimulation of hair follicle stem cell proliferation through an IL-1 dependent activation of γδT-cells Elife  2017 6  DOI:10.7554/eLife.28875  PMID:29199946  PMCID:PMC5714500
    • Nielsen, M. M., Witherden, D. A., Havran, W. L. γδ T cells in homeostasis and host defence of epithelial barrier tissues Nature Reviews Immunology  2017 17:733-745  DOI:10.1038/nri.2017.101  PMID:28920588
    • Ramirez, K., Witherden, D. A., Havran, W. L. All hands on DE(T)C: Epithelial-resident γδ T cells respond to tissue injury Cellular Immunology  2015 296:57-61  DOI:10.1016/j.cellimm.2015.04.003  PMID:25958272  PMCID:PMC4466205
    • Adams, E. J., Havran, W. L. Introduction to Cellular Immunology Special Issue on γδ T cells Cellular Immunology  2015 296:1-2  DOI:10.1016/j.cellimm.2015.06.001  PMID:26070929
    • Nielsen, M. M., Dyring-Andersen, B., Schmidt, J. D., Witherden, D., Lovato, P., Woetmann, A., Odum, N., Poulsen, S. S., Havran, W. L., Geisler, C., Bonefeld, C. M. NKG2D-dependent activation of dendritic epidermal T cells in contact hypersensitivity Journal of Investigative Dermatology  2015 135:1311-1319  DOI:10.1038/jid.2015.23  PMID:25634359  PMCID:PMC4402141
    • Witherden, D. A., Ramirez, K., Havran, W. L. Multiple receptor-ligand interactions direct tissue-resident γδ T cell activation Frontiers in Immunology  2014 5:602  DOI:10.3389/fimmu.2014.00602  PMID:25505467  PMCID:PMC4241470
    • MacLeod, A. S., Rudolph, R., Corriden, R., Ye, I., Garijo, O., Havran, W. L. Skin-resident T cells sense ultraviolet radiation-induced injury and contribute to DNA repair Journal of Immunology  2014 192:5695-5702  DOI:10.4049/jimmunol.1303297  PMID:24808367  PMCID:PMC4048764
    • Nielsen, M. M., Lovato, P., MacLeod, A. S., Witherden, D. A., Skov, L., Dyring-Andersen, B., Dabelsteen, S., Woetmann, A., Odum, N., Havran, W. L., Geisler, C., Bonefeld, C. M. IL-1 beta-dependent activation of dendritic epidermal T cells in contact hypersensitivity Journal of Immunology  2014 192:2975-2983  DOI:10.4049/jimmunol.1301689  PMID:24600030  PMCID:PMC4020443
    • Kronenberg, M., Havran, W. L. Immunology: oiling the wheels of autoimmunity Nature  2014 506:42-43  DOI:10.1038/506042a  PMID:24499914
    • Meehan, T. F., Witherden, D. A., Kim, C. H., Sendaydiego, K., Ye, I., Garijo, O., Komori, H. K., Kumanogoh, A., Kikutani, H., Eckmann, L., Havran, W. L. Protection against colitis by CD100-dependent modulation of intraepithelial gamma delta T lymphocyte function Mucosal immunology  2014 7:134-142  DOI:10.1038/mi.2013.32  PMID:23695512  PMCID:PMC3795871
    • MacLeod, A. S., Hemmers, S., Garijo, O., Chabod, M., Mowen, K., Witherden, D. A., Havran, W. L. Dendritic epidermal T cells regulate skin antimicrobial barrier function Journal of Clinical Investigation  2013 123:4364-4374  DOI:10.1172/jci70064  PMID:24051381  PMCID:PMC3784546
    • Witherden, D. A., Havran, W. L. Cross-talk between intraepithelial gamma delta T cells and epithelial cells Journal of Leukocyte Biology  2013 94:69-76  DOI:10.1189/jlb.0213101  PMID:23620015  PMCID:PMC3685022
    • Witherden, D. A., Watanabe, M., Garijo, O., Rieder, S. E., Sarkisyan, G., Cronin, S. J. F., Verdino, P., Wilson, I. A., Kumanogoh, A., Kikutani, H., Teyton, L., Fischer, W. H., et al. The CD100 receptor interacts with its plexin B2 ligand to regulate epidermal gamma delta T cell function Immunity  2012 37:314-325  DOI:10.1016/j.immuni.2012.05.026  PMID:22902232  PMCID:PMC3430606
    • Komori, H. K., Witherden, D. A., Kelly, R., Sendaydiego, K., Jameson, J. M., Teyton, L., Havran, W. L. Cutting edge: dendritic epidermal gamma delta T cell ligands are rapidly and locally expressed by keratinocytes following cutaneous wounding Journal of Immunology  2012 188:2972-2976  DOI:10.4049/jimmunol.1100887  PMID:22393149  PMCID:PMC3311739
    • Antsiferova, M., Huber, M., Meyer, M., Piwko-Czuchra, A., Ramadan, T., MacLeod, A. S., Havran, W. L., Dummer, R., Hohl, D., Werner, S. Activin enhances skin tumourigenesis and malignant progression by inducing a pro-tumourigenic immune cell response Nature Communications  2011 2:576  DOI:10.1038/ncomms1585  PMID:22146395  PMCID:PMC3247817
    • MacLeod, A. S., Havran, W. L. Functions of skin-resident gamma delta T cells Cellular and Molecular Life Sciences  2011 68:2399-2408  DOI:10.1007/s00018-011-0702-x  PMID:21560071  PMCID:PMC3123394
    • Witherden, D. A., Havran, W. L. Molecular aspects of epithelial gamma delta T cell regulation Trends in Immunology  2011 32:265-271  DOI:10.1016/j.it.2011.03.005  PMID:21481636  PMCID:PMC3109268
    • Verdino, P., Witherden, D. A., Podshivalova, K., Rieder, S. E., Havran, W. L., Wilson, I. A. cDNA sequence and Fab crystal structure of HL4E10, a hamster IgG lambda light chain antibody stimulatory for γδ T cells PLoS One  2011 6:e19828  DOI:10.1371/journal.pone.0019828  PMID:21629689  PMCID:PMC3101210
    • Verdino, P., Witherden, D. A., Ferguson, M. S., Corper, A. L., Schiefner, A., Havran, W. L., Wilson, I. A. Molecular insights into gamma delta T cell costimulation by an anti-JAML antibody Structure  2011 19:80-89  DOI:10.1016/j.str.2010.10.007  PMID:21220118  PMCID:PMC3039130
    • Witherden, D. A., Verdino, P., Rieder, S. E., Garijo, O., Mills, R. E., Teyton, L., Fischer, W. H., Wilson, I. A., Havran, W. L. The junctional adhesion molecule JAML is a costimulatory receptor for epithelial gamma delta T cell activation Science  2010 329:1205-1210  DOI:10.1126/science.1192698  PMID:20813954  PMCID:PMC2943937
    • Verdino, P., Witherden, D. A., Havran, W. L., Wilson, I. A. The molecular interaction of CAR and JAML recruits the central cell signal transducer PI3K Science  2010 329:1210-1214  DOI:10.1126/science.1187996  PMID:20813955  PMCID:PMC2951132
    • Swamy, M., Jamora, C., Havran, W., Hayday, A. Epithelial decision makers: In search of the 'epimmunome' Nature Immunology  2010 11:656-665  DOI:10.1038/ni.1905  PMID:20644571  PMCID:PMC2950874
    • Havran, W. L., Jameson, J. M. Epidermal T cells and wound healing Journal of Immunology  2010 184:5423-5428  DOI:10.4049/jimmunol.0902733  PMID:20483798  PMCID:PMC2944652
    • Toulon, A., Breton, L., Taylor, K. R., Tenenhaus, M., Bhavsar, D., Lanigan, C., Rudolph, R., Jameson, J., Havran, W. L. A role for human skin-resident T cells in wound healing Journal of Experimental Medicine  2009 206:743-750  DOI:10.1084/jem.20081787  PMID:19307328  PMCID:PMC2715110
    • Kim, C. H., Witherden, D. A., Havran, W. L. Characterization and TCR variable region gene use of mouse resident nasal gamma delta T lymphocytes Journal of Leukocyte Biology  2008 84:1259-1263  DOI:10.1189/jlb.0108050  PMID:18667688  PMCID:PMC2567898
    • Yu, D., Cook, M. C., Shin, D. M., Silva, D. G., Marshall, J., Toellner, K. M., Havran, W. L., Caroni, P., Cooke, M. P., Morse, H. C., MacLennan, I. C. M., Goodnow, C. C., et al. Axon growth and guidance genes identify T-dependent germinal centre B cells Immunology and Cell Biology  2008 86:3-14  DOI:10.1038/sj.icb.7100123  PMID:17938642
    • Havran, W. L., Toulon, A. [Les sentinelles de la peau] Pour la Science  2008 368:56-59
    • Jameson, J., Havran, W. L. Skin gamma delta T-cell functions in homeostasis and wound healing Immunological Reviews  2007 215:114-122  DOI:10.1111/j.1600-065X.2006.00483.x  PMID:17291283
    • Komori, H., Meehar, T. F., Havran, W. L. Epithelial and mucosal γδ T cells Current Opinion in Immunology  2006 18:534-538  DOI:10.1016/j.coi.2006.06.001  PMID:16837181
    • Havran, W. L. The biology of gamma delta t cells: What is the relationship between gamma delta t cells and cancer? Will an increased number and/or function of gamma delta t cells result in lower cancer incidence? Journal of Nutrition  2005 135:2909S-2909S
    • Havran, W. L., Jameson, J. M., Witherden, D. A. Epithelial cells and their neighbors. III. Interactions between intraepithelial lymphocytes and neighboring epithelial cells American Journal of Physiology-Gastrointestinal and Liver Physiology  2005 289:G627-G630  DOI:10.1152/ajpgi.00224.2005  PMID:16160077
    • Jameson, J. M., Cauvi, G., Sharp, L. L., Witherden, D. A., Havran, W. L. Gamma delta t cell-induced hyaluronan production by epithelial cells regulates inflammation Journal of Experimental Medicine  2005 201:1269-1279  DOI:10.1084/jem.20042057  PMID:15837812  PMCID:PMC2213158
    • Baccala, R., Witherden, D., Gonzalez-Quintial, R., Dummer, W., Surh, C. D., Havran, W. L., Theofilopoulos, A. N. Gamma delta T cell homeostasis is controlled by IL-7 and IL-15 together with subset-specific factors Journal of Immunology  2005 174:4606-4612  PMID:15814683
    • Sharp, L. L., Jameson, J. M., Cauvi, G., Havran, W. L. Dendritic epidermal T cells regulate skin homeostasis through local production of insulin-like growth factor 1 Nature Immunology  2005 6:73-79  DOI:10.1038/ni1152  PMID:15592472
    • Sharp, L. L., Jameson, J. M., Witherden, D. A., Komori, H. K., Havran, W. L. Dendritic epidermal t-cell activation Critical Reviews in Immunology  2005 25:1-17  DOI:10.1615/CritRevImmunol.v25.i1.10  PMID:15833080
    • Jameson, J. M., Sharp, L. L., Witherden, D. A., Havran, W. L. Regulation of skin cell homeostasis by gamma delta T cells Frontiers in Bioscience  2004 9:2640-2651  DOI:10.2741/1423  PMID:15358587
    • Yui, M. A., Sharp, L. L., Havran, W. L., Rothenberg, E. V. Preferential activation of an IL-2 regulatory sequence transgene in TCR gamma delta and NKT cells: subset-specific differences in IL-2 regulation Journal of Immunology  2004 172:4691-4699  PMID:15067044
    • Jameson, J. M., Cauvi, G., Witherden, D. A., Havran, W. L. A keratinocyte-responsive gamma delta tcr is necessary for dendritic epidermal t cell activation by damaged keratinocytes and maintenance in the epidermis Journal of Immunology  2004 172:3573-3579  PMID:15004158
    • Jameson, J., Witherden, D., Havran, W. L. T-cell effector mechanisms: Gamma delta and CD1d-restricted subsets Current Opinion in Immunology  2003 15:349-353  DOI:10.1016/s0952-7915(03)00045-1  PMID:12787763
    • Chen, Y. P., Chou, K., Fuchs, E., Havran, W. L., Boismenu, R. Protection of the intestinal mucosa by intraepithelial gamma delta T cells Proceedings of the National Academy of Sciences of the United States of America  2002 99:14338-14343  DOI:10.1073/pnas.212290499  PMID:12376619  PMCID:PMC137885
    • Jameson, J., Ugarte, K., Chen, N., Yachi, P., Fuchs, E., Boismenu, R., Havran, W. L. A role for skin γδ T cells in wound repair Science  2002 296:747-749  DOI:10.1126/science.1069639  PMID:11976459
    • Boismenu, R., Havran, W. L. Intraepithelial gamma delta T cells exposed by functional genomics Genome Biology  2001 2:1031  PMID:11737950  PMCID:PMC138983
    • Witherden, D. A., Rieder, S. E., Boismenu, R., Havran, W. L. A role for epithelial gamma delta T cells in tissue repair Springer Seminars in Immunopathology  2000 22:265-281  DOI:10.1007/s002810000045  PMID:11116957
    • Witherden, D. A., Boismenu, R., Havran, W. L. Cd81 and cd28 costimulate t cells through distinct pathways Journal of Immunology  2000 165:1902-1909  PMID:10925271
    • Meharra, E. J., Schon, M., Hassett, D., Parker, C., Havran, W., Gardner, H. Reduced gut intraepithelial lymphocytes in vla1 null mice Cellular Immunology  2000 201:1-5  DOI:10.1006/cimm.2000.1630  PMID:10805967
    • Havran, W. L. A role for epithelial gamma delta T cells in tissue repair Immunologic Research  2000 21:63-69  DOI:10.1385/ir:21:2-3:63  PMID:10852103
    • Boismenu, R., Chen, Y. P., Havran, W. L. The role of intraepithelial gamma delta T cells: A gut-feeling Microbes and Infection  1999 1:235-240  DOI:10.1016/s1286-4579(99)80039-2  PMID:10801235
    • Bain, G., Romanow, W. J., Albers, K., Havran, W. L., Murre, C. Positive and negative regulation of v(d)j recombination by the e2a proteins Journal of Experimental Medicine  1999 189:289-300  DOI:10.1084/jem.189.2.289  PMID:9892611
    • Boismenu, R., Havran, W. L. Gamma delta t cells in host defense and epithelial cell biology Clinical Immunology and Immunopathology  1998 86:121-133  DOI:10.1006/clin.1997.4468  PMID:9473374
    • Punt, J. A., Havran, W., Abe, R., Sarin, A., Singer, A. T cell receptor (tcr)-induced death of immature cd4(+)cd8(+) thymocytes by two distinct mechanisms differing in their requirement for cd28 costimulation: Implications for negative selection in the thymus Journal of Experimental Medicine  1997 186:1911-1922  DOI:10.1084/jem.186.11.1911  PMID:9382889
    • Domanico, S. Z., Pelletier, A. J., Havran, W. L., Quaranta, V. Integrin alpha 6a beta 1 induces cd81-dependent cell motility without engaging the extracellular matrix migration substrate Molecular Biology of the Cell  1997 8:2253-2265  PMID:9362067  PMCID:PMC25706
    • DeKoning, J., DiMolfetto, L., Reilly, C., Wei, Q., Havran, W. L., Lo, D. Thymic cortical epithelium is sufficient for the development of mature t cells in relb-deficient mice Journal of Immunology  1997 158:2558-2566  PMID:9058787
    • Boismenu, R., Havran, W. L. An innate view of gamma delta t cells Current Opinion in Immunology  1997 9:57-63  DOI:10.1016/s0952-7915(97)80159-8  PMID:9039779
    • Boismenu, R., Feng, L. L., Xia, Y. Y., Chang, J. C. C., Havran, W. L. Chemokine expression by intraepithelial gamma delta t cells - implications for the recruitment of inflammatory cells to damaged epithelia Journal of Immunology  1996 157:985-992  PMID:8757601
    • Boismenu, R., Rhein, M., Fischer, W. H., Havran, W. L. A role for cd81 in early t cell development Science  1996 271:198-200  DOI:10.1126/science.271.5246.198  PMID:8539618
    • Boismenu, R., Hobbs, M. V., Boullier, S., Havran, W. L. Molecular and cellular biology of dendritic epidermal T cells Seminars in Immunology  1996 8:323-331  DOI:10.1006/smim.1996.0043  PMID:8961383
    • Boismenu, R., Havran, W. L. T-cell development - t-cell lineage commitment revisited Current Biology  1995 5:829-831  DOI:10.1016/s0960-9822(95)00164-3  PMID:7583132
    • Havran, W. L., Boismenu, R. KGF expression reveals a specialized function for epithelial gamma delta T cells Journal of NIH Research  1995 7:57
    • Boismenu, R., Havran, W. L. Modulation of epithelial-cell growth by intraepithelial gamma-delta T-cells Science  1994 266:1253-1255  DOI:10.1126/science.7973709  PMID:7973709
    • Havran, W. L., Boismenu, R. Activation and function of gamma-delta t-cells Current Opinion in Immunology  1994 6:442-446  DOI:10.1016/0952-7915(94)90125-2  PMID:7917113
    • Lefrancois, L., Barrett, T. A., Havran, W. L., Puddington, L. Developmental expression of the alpha(iel)beta(7) integrin on t-cell receptor-gamma-delta and t-cell receptor-alpha-beta t-cells European Journal of Immunology  1994 24:635-640  DOI:10.1002/eji.1830240322  PMID:7907296
    • Havran, W. L., Chien, Y. H., Allison, J. P. Recognition of self antigens by skin-derived t-cells with invariant gamma-delta-antigen receptors Science  1991 252:1430-1432  DOI:10.1126/science.1828619  PMID:1828619
    • Allison, J. P., Asarnow, D. M., Bonyhadi, M., Carbone, A., Havran, W. L., Nandi, D., Noble, J. Gamma delta T cells in murine epithelia: origin, repertoire, and function Advances in Experimental Medicine and Biology  1991 292:63-69  DOI:10.1007/978-1-4684-5943-2_8  PMID:1835264
    • Havran, W. L., Carbone, A., Allison, J. P. Murine T cells with invariant gamma delta antigen receptors: origin, repertoire, and specificity Seminars in Immunology  1991 3:89-97  PMID:1716172
    • Havran, W. L., Allison, J. P. Ontogeny of epithelial gamma delta T lymphocytes Progress in Leukocyte Biology  1991 11:37-42
    • Allison, J. P., Havran, W. L. The immunobiology of t-cells with invariant gamma-delta antigen receptors Annual Review of Immunology  1991 9:679-705  DOI:10.1146/annurev.immunol.9.1.679  PMID:1832874
    • Havran, W. L., Allison, J. P. Origin of thy-1+ dendritic epidermal-cells of adult mice from fetal thymic precursors Nature  1990 344:68-70  DOI:10.1038/344068a0  PMID:1968230
    • Gelber, C., Jensen, L. M., Havran, W. L., Morse, R. Y., Goodenow, R. S. Expression of MHC Qa-2 antigens and the T cell receptor repertoire UCLA Symposia on Molecular and Cellular Biology, New Series  1990 135:189-192
    • Havran, W. L., Grell, S., Duwe, G., Kimura, J., Wilson, A., Kruisbeek, A. M., Obrien, R. L., Born, W., Tigelaar, R. E., Allison, J. P. Limited diversity of t-cell receptor gamma-chain expression of murine thy-1+ dendritic epidermal-cells revealed by v-gamma-3-specific monoclonal-antibody Proceedings of the National Academy of Sciences of the United States of America  1989 86:4185-4189  DOI:10.1073/pnas.86.11.4185  PMID:2726770
    • Havran, W. L., Poenie, M., Tigelaar, R. E., Tsien, R. Y., Allison, J. P. Phenotypic and functional-analysis of gamma-delta-t-cell receptor-positive murine dendritic epidermal clones Journal of Immunology  1989 142:1422-1428  PMID:2783942
    • Havran, W. L., Allison, J. P. Developmentally ordered appearance of thymocytes expressing different t-cell antigen receptors Nature  1988 335:443-445  DOI:10.1038/335443a0  PMID:2458531
    • Portmann, L., Fitch, F. W., Havran, W., Hamada, N., Franklin, W. A., Degroot, L. J. Characterization of the thyroid microsomal antigen, and its relationship to thyroid peroxidase, using monoclonal-antibodies Journal of Clinical Investigation  1988 81:1217-1224  DOI:10.1172/jci113438  PMID:3280602
    • Havran, W. L., Lancki, D. W., Moldwin, R. L., Dialynas, D. P., Fitch, F. W. Characterization of an anti-ly-6 monoclonal-antibody which defines and activates cytolytic lymphocytes-t Journal of Immunology  1988 140:1034-1042  PMID:3257767
    • Fitch, F., Lancki, D., Havran, W. Kochs postulates and the molecular-biology of t-cell function Immunology Today  1988 9:41-43  DOI:10.1016/0167-5699(88)91257-1  PMID:3267168
    • Havran, W. L., Fitch, F. W. Effects of anti-Lyt-2 and anti-L3T4 monoclonal antibodies on the function of cytotoxic T lymphocyte/helper T lymphocyte hybrid T cell clones Journal of Immunology  1988 141:1808-1812  PMID:2459190
    • Allison, J. P., Havran, W. L., Poenie, M., Kimura, J., DeGraffenreid, L., Ajami, S., Duwe, G., Weiss, A., Tsien, R. Expression and function of CD3 on murine thymocytes UCLA Symposia on Molecular and Cellular Biology, New Series  1988 73:33-45
    • Allison, J. P., Havran, W. L., Asarnow, D., Tigelaar, R. E., Tucker, P. W., Bonyhadi, M. Gamma-delta-antigen receptors of thy-1+ dendritic epidermal-cells - implications for thymic differentiation Immunologic Research  1988 7:292-302  DOI:10.1007/bf02935534  PMID:2906352
    • Havran, W. L., Poenie, M., Kimura, J., Tsien, R., Weiss, A., Allison, J. P. Expression and function of the cd3-antigen receptor on murine cd4+8+ thymocytes Nature  1987 330:170-173  DOI:10.1038/330170a0  PMID:2959867
    • Moldwin, R. L., Havran, W. L., Nau, G. J., Lancki, D. W., Kim, D. K., Fitch, F. W. Antibodies to the l3t4 and lyt-2 molecules interfere with antigen receptor-driven activation of cloned murine t-cells Journal of Immunology  1987 139:657-664  PMID:2955046
    • Moldwin, R. L., Nau, G. J., Havran, W. L., Lancki, D. W., Fitch, F. W. Anti-l3t4 monoclonal-antibody inhibits t-cell activation by anti-t-cell receptor antibody through a pathway not involving associative recognition Annales de l'Institut Pasteur - Immunology  1987 138:131-134  PMID:3107585
    • Havran, W. L., Fitch, F. W. Characterization of murine cytolytic-helper hybrid t-cell clones Nature  1987 325:65-67  DOI:10.1038/325065a0  PMID:2948129
    • Tripathi, B. J., Tripathi, R. C., Stefansson, K., Havran, W. L., Fitch, F. W. Monoclonal antibodies to human trabecular endothelium. A preliminary report on production and characterization Experimental Eye Research  1986 43:863-866  DOI:10.1016/s0014-4835(86)80016-1  PMID:2433139
    • Havran, W. L., Kim, D. K., Moldwin, R. L., Lancki, D. W., Fitch, F. W. Interleukin-2 differentially regulates il-2 receptors on murine cloned cytolytic and helper t-cells Clinical Immunology and Immunopathology  1986 39:368-378  DOI:10.1016/0090-1229(86)90165-0  PMID:2938859
    • Kim, D. K., Havran, W. L., Moldwin, R. L., Lancki, D. W., Fitch, F. W. IL-2 regulates IL-2 receptor expression on murine T cell clones ICSU Short Reports  1985 2:195-196
    • Lancki, D. W., Ma, D. I., Havran, W. L., Fitch, F. W. Cell-surface structures involved in t-cell activation Immunological Reviews  1984 81:65-94  DOI:10.1111/j.1600-065X.1984.tb01105.x  PMID:6239820
    • Havran, W. L., Digiusto, D. L., Cambier, J. C. Migm-migd ratios on b-cells - mean migd expression exceeds migm by 10-fold on most splenic b-cells Journal of Immunology  1984 132:1712-1716  PMID:6421926
    • Dialynas, D. P., Wilde, D. B., Marrack, P., Pierres, A., Wall, K. A., Havran, W., Otten, G., Loken, M. R., Pierres, M., Kappler, J., Fitch, F. W. Characterization of the murine antigenic determinant, designated l3t4a, recognized by monoclonal-antibody gk1.5 - expression of l3t4a by functional t-cell clones appears to correlate primarily with class ii mhc antigen-reactivity Immunological Reviews  1983 74:29-56  DOI:10.1111/j.1600-065X.1983.tb01083.x  PMID:6195085
    • Monroe, J. G., Havran, W. L., Cambier, J. C. Lymphocyte-b activation - entry into cell-cycle is accompanied by decreased expression of igd but not igm European Journal of Immunology  1983 13:208-213  DOI:10.1002/eji.1830130306  PMID:6601015
    • Monroe, J. G., Havran, W. L., Cambier, J. C. Enrichment of viable lymphocytes in defined cycle phases by sorting on the basis of pulse width of axial light extinction Cytometry  1982 3:24-27  DOI:10.1002/cyto.990030107  PMID:6180872
    • Cambier, J. C., Havran, W. L., Dealbornoz, T. F., Corley, R. B. Identification of a brain theta-positive, secretory-cell from hematopoietic tissues Journal of Immunology  1981 127:1685-1691  PMID:7196931

featured in

  • Mysterious gamma delta T Cells Promote Wound Repair  Newsletter
  • Scripps Research Institute Scientists Discover Important Wound-Healing Process  News Release
  • Scripps Research Scientists Find Important Molecular Trigger for Wound-Healing  News Release
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Research

research overview

  • We have a long-term interest in interactions between intraepithelial γδ T cells and their neighboring epithelial cells. Epithelial tissues including the skin, intestine and lungs are the first point of contact between the immune system and the outside world. The intraepithelial γδ T cells provide a first line of defense in these tissues. Our results have defined unique properties of these cells and support a specialized role for epithelial γδ T cells in immune surveillance, wound repair, inflammation, and protection from malignancy. We have identified cell surface molecules and growth factors that regulate epithelial T cell functional responses that have increased our understanding of the role that these cells play in epithelial and mucosal diseases such as inflammatory bowel disease, asthma, malignancies and wound healing. Chronic wounds are a debilitating problem and new information gained from these studies will be utilized to modulate γδ T cell responses and develop new strategies to accelerate healing.
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Teaching

advisees

  • graduate advising relationship

    • Johnson, Daisy, Ph.D.  candidate, 2015 -
    • McGraw, Joseph Mike, Ph.D.  candidate, 2016 -
    • Komori-Occhicone, Heather Kiyomi, Ph.D.  candidate, 2003 - 2008
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Background

education and training

  • Ph.D. in Immunology, The University of Chicago 1986
  • B.S. in Zoology, Duke University 1977

awards and honors

  • Distinguished Service Award, conferred by Council of The American Association of Immunologists, 2018
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Contact

full name

  • Wendy L. Havran

geographic location

  • Scripps California 

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