Havran, Wendy

Faculty Member

Positions

Professor Adjunct, Department of Medicine, School of Medicine, University of California, San Diego
2017 - 2020 Professor, Immunology and Microbiology , Scripps Research
1991 - 2020 Faculty Member, Skaggs Graduate School of Chemical and Biological Sciences , Scripps Research
1991 - 2016 Professor, Immunology and Microbial Science (IMS) , Scripps Research

Dr. Wendy Havran studies a unique subset of T lymphocytes, called "gamma-delta" T cells, which reside in epithelial tissues, are derived from fetal precursors, express a tissue-specific, invariant antigen receptor, and are involved in tissue repair as well as epithelial inflammatory diseases such as asthma and ulcerative colitis.

Research Areas

Cancer (UMLS)

Websites

Havran Laboratory

Publications
Research
Teaching
Background
Contact
View All

recent publications

academic article
- Soley, B. D., Silva, L. M., Mendes, Dagb, Bafica, A., Pesquero, J. B., Bader, M., Witherden, D. A., Havran, W. L., Calixto, J. B., Otuki, M. F., Cabrini, D. A. B-1 and B-2 kinin receptor blockade improves psoriasis-like disease British Journal of Pharmacology 2020 DOI:10.1111/bph.15077 PMID:32335893
- Johnson, M. D., Witherden, D. A., Havran, W. L. The Role of Tissue-resident γδ T Cells in Stress Surveillance and Tissue Maintenance Cells 2020 9 DOI:10.3390/cells9030686 PMID:32168884 PMCID:PMC7140644
- Witherden, D. A., Johnson, M. D., Havran, W. L. Coreceptors and their ligands in epithelial γδ T cell Bbology Frontiers in Immunology 2018 9 DOI:10.3389/fimmu.2018.00731 PMID:29686687 PMCID:PMC5900413
- Havran, W. L. Specialized antitumor functions for Skin γδ T cells Journal of Immunology 2018 200:3029-3030 DOI:10.4049/jimmunol.1800356 PMID:29685948
- McGraw, J., Havran, W. L. γδ T cells and IgE team up to prevent tumors Nature Immunology 2018 19:793-795 DOI:10.1038/s41590-018-0167-2 PMID:30013144
- Lee, P., Gund, R., Dutta, A., Pincha, N., Rana, I., Ghosh, S., Witherden, D., Kandyba, E., MacLeod, A., Kobielak, K., Havran, W. L., Jamora, C. Stimulation of hair follicle stem cell proliferation through an IL-1 dependent activation of γδT-cells Elife 2017 6 DOI:10.7554/eLife.28875 PMID:29199946 PMCID:PMC5714500
- Nielsen, M. M., Witherden, D. A., Havran, W. L. γδ T cells in homeostasis and host defence of epithelial barrier tissues Nature Reviews Immunology 2017 17:733-745 DOI:10.1038/nri.2017.101 PMID:28920588
- Adams, E. J., Havran, W. L. Introduction to Cellular Immunology Special Issue on γδ T cells Cellular Immunology 2015 296:1-2 DOI:10.1016/j.cellimm.2015.06.001 PMID:26070929
- Ramirez, K., Witherden, D. A., Havran, W. L. All hands on DE(T)C: Epithelial-resident γδ T cells respond to tissue injury Cellular Immunology 2015 296:57-61 DOI:10.1016/j.cellimm.2015.04.003 PMID:25958272 PMCID:PMC4466205
- Nielsen, M. M., Dyring-Andersen, B., Schmidt, J. D., Witherden, D., Lovato, P., Woetmann, A., Odum, N., Poulsen, S. S., Havran, W. L., Geisler, C., Bonefeld, C. M. NKG2D-dependent activation of dendritic epidermal T cells in contact hypersensitivity Journal of Investigative Dermatology 2015 135:1311-1319 DOI:10.1038/jid.2015.23 PMID:25634359 PMCID:PMC4402141
- Nielsen, M. M., Lovato, P., MacLeod, A. S., Witherden, D. A., Skov, L., Dyring-Andersen, B., Dabelsteen, S., Woetmann, A., Odum, N., Havran, W. L., Geisler, C., Bonefeld, C. M. IL-1 beta-dependent activation of dendritic epidermal T cells in contact hypersensitivity Journal of Immunology 2014 192:2975-2983 DOI:10.4049/jimmunol.1301689 PMID:24600030 PMCID:PMC4020443
- Kronenberg, M., Havran, W. L. Immunology: oiling the wheels of autoimmunity Nature 2014 506:42-43 DOI:10.1038/506042a PMID:24499914
- Witherden, D. A., Ramirez, K., Havran, W. L. Multiple receptor-ligand interactions direct tissue-resident γδ T cell activation Frontiers in Immunology 2014 5:602 DOI:10.3389/fimmu.2014.00602 PMID:25505467 PMCID:PMC4241470
- Meehan, T. F., Witherden, D. A., Kim, C. H., Sendaydiego, K., Ye, I., Garijo, O., Komori, H. K., Kumanogoh, A., Kikutani, H., Eckmann, L., Havran, W. L. Protection against colitis by CD100-dependent modulation of intraepithelial gamma delta T lymphocyte function Mucosal immunology 2014 7:134-142 DOI:10.1038/mi.2013.32 PMID:23695512 PMCID:PMC3795871
- MacLeod, A. S., Rudolph, R., Corriden, R., Ye, I., Garijo, O., Havran, W. L. Skin-resident T cells sense ultraviolet radiation-induced injury and contribute to DNA repair Journal of Immunology 2014 192:5695-5702 DOI:10.4049/jimmunol.1303297 PMID:24808367 PMCID:PMC4048764
- Witherden, D. A., Havran, W. L. Cross-talk between intraepithelial gamma delta T cells and epithelial cells Journal of Leukocyte Biology 2013 94:69-76 DOI:10.1189/jlb.0213101 PMID:23620015 PMCID:PMC3685022
- MacLeod, A. S., Hemmers, S., Garijo, O., Chabod, M., Mowen, K., Witherden, D. A., Havran, W. L. Dendritic epidermal T cells regulate skin antimicrobial barrier function Journal of Clinical Investigation 2013 123:4364-4374 DOI:10.1172/jci70064 PMID:24051381 PMCID:PMC3784546
- Komori, H. K., Witherden, D. A., Kelly, R., Sendaydiego, K., Jameson, J. M., Teyton, L., Havran, W. L. Cutting edge: dendritic epidermal gamma delta T cell ligands are rapidly and locally expressed by keratinocytes following cutaneous wounding Journal of Immunology 2012 188:2972-2976 DOI:10.4049/jimmunol.1100887 PMID:22393149 PMCID:PMC3311739
- Witherden, D. A., Watanabe, M., Garijo, O., Rieder, S. E., Sarkisyan, G., Cronin, S. J. F., Verdino, P., Wilson, I. A., Kumanogoh, A., Kikutani, H., Teyton, L., Fischer, W. H., et al. The CD100 receptor interacts with its plexin B2 ligand to regulate epidermal gamma delta T cell function Immunity 2012 37:314-325 DOI:10.1016/j.immuni.2012.05.026 PMID:22902232 PMCID:PMC3430606
- Antsiferova, M., Huber, M., Meyer, M., Piwko-Czuchra, A., Ramadan, T., MacLeod, A. S., Havran, W. L., Dummer, R., Hohl, D., Werner, S. Activin enhances skin tumourigenesis and malignant progression by inducing a pro-tumourigenic immune cell response Nature Communications 2011 2:576 DOI:10.1038/ncomms1585 PMID:22146395 PMCID:PMC3247817
- MacLeod, A. S., Havran, W. L. Functions of skin-resident gamma delta T cells Cellular and Molecular Life Sciences 2011 68:2399-2408 DOI:10.1007/s00018-011-0702-x PMID:21560071 PMCID:PMC3123394
- Witherden, D. A., Havran, W. L. Molecular aspects of epithelial gamma delta T cell regulation Trends in Immunology 2011 32:265-271 DOI:10.1016/j.it.2011.03.005 PMID:21481636 PMCID:PMC3109268
- Verdino, P., Witherden, D. A., Ferguson, M. S., Corper, A. L., Schiefner, A., Havran, W. L., Wilson, I. A. Molecular insights into gamma delta T cell costimulation by an anti-JAML antibody Structure 2011 19:80-89 DOI:10.1016/j.str.2010.10.007 PMID:21220118 PMCID:PMC3039130
- Verdino, P., Witherden, D. A., Podshivalova, K., Rieder, S. E., Havran, W. L., Wilson, I. A. cDNA sequence and Fab crystal structure of HL4E10, a hamster IgG lambda light chain antibody stimulatory for γδ T cells PLoS One 2011 6:e19828 DOI:10.1371/journal.pone.0019828 PMID:21629689 PMCID:PMC3101210
- Havran, W. L., Jameson, J. M. Epidermal T cells and wound healing Journal of Immunology 2010 184:5423-5428 DOI:10.4049/jimmunol.0902733 PMID:20483798 PMCID:PMC2944652
- Swamy, M., Jamora, C., Havran, W., Hayday, A. Epithelial decision makers: In search of the 'epimmunome' Nature Immunology 2010 11:656-665 DOI:10.1038/ni.1905 PMID:20644571 PMCID:PMC2950874
- Witherden, D. A., Verdino, P., Rieder, S. E., Garijo, O., Mills, R. E., Teyton, L., Fischer, W. H., Wilson, I. A., Havran, W. L. The junctional adhesion molecule JAML is a costimulatory receptor for epithelial gamma delta T cell activation Science 2010 329:1205-1210 DOI:10.1126/science.1192698 PMID:20813954 PMCID:PMC2943937
- Verdino, P., Witherden, D. A., Havran, W. L., Wilson, I. A. The molecular interaction of CAR and JAML recruits the central cell signal transducer PI3K Science 2010 329:1210-1214 DOI:10.1126/science.1187996 PMID:20813955 PMCID:PMC2951132
- Toulon, A., Breton, L., Taylor, K. R., Tenenhaus, M., Bhavsar, D., Lanigan, C., Rudolph, R., Jameson, J., Havran, W. L. A role for human skin-resident T cells in wound healing Journal of Experimental Medicine 2009 206:743-750 DOI:10.1084/jem.20081787 PMID:19307328 PMCID:PMC2715110
- Yu, D., Cook, M. C., Shin, D. M., Silva, D. G., Marshall, J., Toellner, K. M., Havran, W. L., Caroni, P., Cooke, M. P., Morse, H. C., MacLennan, I. C. M., Goodnow, C. C., et al. Axon growth and guidance genes identify T-dependent germinal centre B cells Immunology and Cell Biology 2008 86:3-14 DOI:10.1038/sj.icb.7100123 PMID:17938642
- Kim, C. H., Witherden, D. A., Havran, W. L. Characterization and TCR variable region gene use of mouse resident nasal gamma delta T lymphocytes Journal of Leukocyte Biology 2008 84:1259-1263 DOI:10.1189/jlb.0108050 PMID:18667688 PMCID:PMC2567898
- Havran, W. L., Toulon, A. [Les sentinelles de la peau] Pour la Science 2008 368:56-59
- Jameson, J., Havran, W. L. Skin gamma delta T-cell functions in homeostasis and wound healing Immunological Reviews 2007 215:114-122 DOI:10.1111/j.1600-065X.2006.00483.x PMID:17291283
- Komori, H., Meehar, T. F., Havran, W. L. Epithelial and mucosal γδ T cells Current Opinion in Immunology 2006 18:534-538 DOI:10.1016/j.coi.2006.06.001 PMID:16837181
- Sharp, L. L., Jameson, J. M., Cauvi, G., Havran, W. L. Dendritic epidermal T cells regulate skin homeostasis through local production of insulin-like growth factor 1 Nature Immunology 2005 6:73-79 DOI:10.1038/ni1152 PMID:15592472
- Sharp, L. L., Jameson, J. M., Witherden, D. A., Komori, H. K., Havran, W. L. Dendritic epidermal t-cell activation Critical Reviews in Immunology 2005 25:1-17 DOI:10.1615/CritRevImmunol.v25.i1.10 PMID:15833080
- Havran, W. L., Jameson, J. M., Witherden, D. A. Epithelial cells and their neighbors. III. Interactions between intraepithelial lymphocytes and neighboring epithelial cells American Journal of Physiology-Gastrointestinal and Liver Physiology 2005 289:G627-G630 DOI:10.1152/ajpgi.00224.2005 PMID:16160077
- Baccala, R., Witherden, D., Gonzalez-Quintial, R., Dummer, W., Surh, C. D., Havran, W. L., Theofilopoulos, A. N. Gamma delta T cell homeostasis is controlled by IL-7 and IL-15 together with subset-specific factors Journal of Immunology 2005 174:4606-4612 PMID:15814683
- Jameson, J. M., Cauvi, G., Sharp, L. L., Witherden, D. A., Havran, W. L. Gamma delta t cell-induced hyaluronan production by epithelial cells regulates inflammation Journal of Experimental Medicine 2005 201:1269-1279 DOI:10.1084/jem.20042057 PMID:15837812 PMCID:PMC2213158
- Havran, W. L. The biology of gamma delta t cells: What is the relationship between gamma delta t cells and cancer? Will an increased number and/or function of gamma delta t cells result in lower cancer incidence? Journal of Nutrition 2005 135:2909S-2909S
- Jameson, J. M., Cauvi, G., Witherden, D. A., Havran, W. L. A keratinocyte-responsive gamma delta tcr is necessary for dendritic epidermal t cell activation by damaged keratinocytes and maintenance in the epidermis Journal of Immunology 2004 172:3573-3579 PMID:15004158
- Yui, M. A., Sharp, L. L., Havran, W. L., Rothenberg, E. V. Preferential activation of an IL-2 regulatory sequence transgene in TCR gamma delta and NKT cells: subset-specific differences in IL-2 regulation Journal of Immunology 2004 172:4691-4699 PMID:15067044
- Jameson, J. M., Sharp, L. L., Witherden, D. A., Havran, W. L. Regulation of skin cell homeostasis by gamma delta T cells Frontiers in Bioscience 2004 9:2640-2651 DOI:10.2741/1423 PMID:15358587
- Jameson, J., Witherden, D., Havran, W. L. T-cell effector mechanisms: Gamma delta and CD1d-restricted subsets Current Opinion in Immunology 2003 15:349-353 DOI:10.1016/s0952-7915(03)00045-1 PMID:12787763
- Jameson, J., Ugarte, K., Chen, N., Yachi, P., Fuchs, E., Boismenu, R., Havran, W. L. A role for skin γδ T cells in wound repair Science 2002 296:747-749 DOI:10.1126/science.1069639 PMID:11976459
- Chen, Y. P., Chou, K., Fuchs, E., Havran, W. L., Boismenu, R. Protection of the intestinal mucosa by intraepithelial gamma delta T cells Proceedings of the National Academy of Sciences of the United States of America 2002 99:14338-14343 DOI:10.1073/pnas.212290499 PMID:12376619 PMCID:PMC137885
- Boismenu, R., Havran, W. L. Intraepithelial gamma delta T cells exposed by functional genomics Genome Biology 2001 2:1031 PMID:11737950 PMCID:PMC138983
- Havran, W. L. A role for epithelial gamma delta T cells in tissue repair Immunologic Research 2000 21:63-69 DOI:10.1385/ir:21:2-3:63 PMID:10852103
- Witherden, D. A., Rieder, S. E., Boismenu, R., Havran, W. L. A role for epithelial gamma delta T cells in tissue repair Springer Seminars in Immunopathology 2000 22:265-281 DOI:10.1007/s002810000045 PMID:11116957
- Witherden, D. A., Boismenu, R., Havran, W. L. Cd81 and cd28 costimulate t cells through distinct pathways Journal of Immunology 2000 165:1902-1909 PMID:10925271
- Meharra, E. J., Schon, M., Hassett, D., Parker, C., Havran, W., Gardner, H. Reduced gut intraepithelial lymphocytes in vla1 null mice Cellular Immunology 2000 201:1-5 DOI:10.1006/cimm.2000.1630 PMID:10805967
- Bain, G., Romanow, W. J., Albers, K., Havran, W. L., Murre, C. Positive and negative regulation of v(d)j recombination by the e2a proteins Journal of Experimental Medicine 1999 189:289-300 DOI:10.1084/jem.189.2.289 PMID:9892611
- Boismenu, R., Chen, Y. P., Havran, W. L. The role of intraepithelial gamma delta T cells: A gut-feeling Microbes and Infection 1999 1:235-240 DOI:10.1016/s1286-4579(99)80039-2 PMID:10801235
- Boismenu, R., Havran, W. L. Gamma delta t cells in host defense and epithelial cell biology Clinical Immunology and Immunopathology 1998 86:121-133 DOI:10.1006/clin.1997.4468 PMID:9473374
- Boismenu, R., Havran, W. L. An innate view of gamma delta t cells Current Opinion in Immunology 1997 9:57-63 DOI:10.1016/s0952-7915(97)80159-8 PMID:9039779
- Domanico, S. Z., Pelletier, A. J., Havran, W. L., Quaranta, V. Integrin alpha 6a beta 1 induces cd81-dependent cell motility without engaging the extracellular matrix migration substrate Molecular Biology of the Cell 1997 8:2253-2265 PMID:9362067 PMCID:PMC25706
- Punt, J. A., Havran, W., Abe, R., Sarin, A., Singer, A. T cell receptor (tcr)-induced death of immature cd4(+)cd8(+) thymocytes by two distinct mechanisms differing in their requirement for cd28 costimulation: Implications for negative selection in the thymus Journal of Experimental Medicine 1997 186:1911-1922 DOI:10.1084/jem.186.11.1911 PMID:9382889
- DeKoning, J., DiMolfetto, L., Reilly, C., Wei, Q., Havran, W. L., Lo, D. Thymic cortical epithelium is sufficient for the development of mature t cells in relb-deficient mice Journal of Immunology 1997 158:2558-2566 PMID:9058787
- Boismenu, R., Rhein, M., Fischer, W. H., Havran, W. L. A role for cd81 in early t cell development Science 1996 271:198-200 DOI:10.1126/science.271.5246.198 PMID:8539618
- Boismenu, R., Feng, L. L., Xia, Y. Y., Chang, J. C. C., Havran, W. L. Chemokine expression by intraepithelial gamma delta t cells - implications for the recruitment of inflammatory cells to damaged epithelia Journal of Immunology 1996 157:985-992 PMID:8757601
- Boismenu, R., Hobbs, M. V., Boullier, S., Havran, W. L. Molecular and cellular biology of dendritic epidermal T cells Seminars in Immunology 1996 8:323-331 DOI:10.1006/smim.1996.0043 PMID:8961383
- Havran, W. L., Boismenu, R. KGF expression reveals a specialized function for epithelial gamma delta T cells Journal of NIH Research 1995 7:57
- Boismenu, R., Havran, W. L. T-cell development - t-cell lineage commitment revisited Current Biology 1995 5:829-831 DOI:10.1016/s0960-9822(95)00164-3 PMID:7583132
- Havran, W. L., Boismenu, R. Activation and function of gamma-delta t-cells Current Opinion in Immunology 1994 6:442-446 DOI:10.1016/0952-7915(94)90125-2 PMID:7917113
- Lefrancois, L., Barrett, T. A., Havran, W. L., Puddington, L. Developmental expression of the alpha(iel)beta(7) integrin on t-cell receptor-gamma-delta and t-cell receptor-alpha-beta t-cells European Journal of Immunology 1994 24:635-640 DOI:10.1002/eji.1830240322 PMID:7907296
- Boismenu, R., Havran, W. L. Modulation of epithelial-cell growth by intraepithelial gamma-delta T-cells Science 1994 266:1253-1255 DOI:10.1126/science.7973709 PMID:7973709
- Allison, J. P., Asarnow, D. M., Bonyhadi, M., Carbone, A., Havran, W. L., Nandi, D., Noble, J. Gamma delta T cells in murine epithelia: origin, repertoire, and function Advances in Experimental Medicine and Biology 1991 292:63-69 DOI:10.1007/978-1-4684-5943-2_8 PMID:1835264
- Havran, W. L., Carbone, A., Allison, J. P. Murine T cells with invariant gamma delta antigen receptors: origin, repertoire, and specificity Seminars in Immunology 1991 3:89-97 PMID:1716172
- Havran, W. L., Allison, J. P. Ontogeny of epithelial gamma delta T lymphocytes Progress in Leukocyte Biology 1991 11:37-42
- Havran, W. L., Chien, Y. H., Allison, J. P. Recognition of self antigens by skin-derived t-cells with invariant gamma-delta-antigen receptors Science 1991 252:1430-1432 DOI:10.1126/science.1828619 PMID:1828619
- Allison, J. P., Havran, W. L. The immunobiology of t-cells with invariant gamma-delta antigen receptors Annual Review of Immunology 1991 9:679-705 DOI:10.1146/annurev.immunol.9.1.679 PMID:1832874
- Gelber, C., Jensen, L. M., Havran, W. L., Morse, R. Y., Goodenow, R. S. Expression of MHC Qa-2 antigens and the T cell receptor repertoire UCLA Symposia on Molecular and Cellular Biology, New Series 1990 135:189-192
- Havran, W. L., Allison, J. P. Origin of thy-1+ dendritic epidermal-cells of adult mice from fetal thymic precursors Nature 1990 344:68-70 DOI:10.1038/344068a0 PMID:1968230
- Havran, W. L., Grell, S., Duwe, G., Kimura, J., Wilson, A., Kruisbeek, A. M., Obrien, R. L., Born, W., Tigelaar, R. E., Allison, J. P. Limited diversity of t-cell receptor gamma-chain expression of murine thy-1+ dendritic epidermal-cells revealed by v-gamma-3-specific monoclonal-antibody Proceedings of the National Academy of Sciences of the United States of America 1989 86:4185-4189 DOI:10.1073/pnas.86.11.4185 PMID:2726770
- Havran, W. L., Poenie, M., Tigelaar, R. E., Tsien, R. Y., Allison, J. P. Phenotypic and functional-analysis of gamma-delta-t-cell receptor-positive murine dendritic epidermal clones Journal of Immunology 1989 142:1422-1428 PMID:2783942
- Havran, W. L., Lancki, D. W., Moldwin, R. L., Dialynas, D. P., Fitch, F. W. Characterization of an anti-ly-6 monoclonal-antibody which defines and activates cytolytic lymphocytes-t Journal of Immunology 1988 140:1034-1042 PMID:3257767
- Portmann, L., Fitch, F. W., Havran, W., Hamada, N., Franklin, W. A., Degroot, L. J. Characterization of the thyroid microsomal antigen, and its relationship to thyroid peroxidase, using monoclonal-antibodies Journal of Clinical Investigation 1988 81:1217-1224 DOI:10.1172/jci113438 PMID:3280602
- Havran, W. L., Allison, J. P. Developmentally ordered appearance of thymocytes expressing different t-cell antigen receptors Nature 1988 335:443-445 DOI:10.1038/335443a0 PMID:2458531
- Havran, W. L., Fitch, F. W. Effects of anti-Lyt-2 and anti-L3T4 monoclonal antibodies on the function of cytotoxic T lymphocyte/helper T lymphocyte hybrid T cell clones Journal of Immunology 1988 141:1808-1812 PMID:2459190
- Allison, J. P., Havran, W. L., Poenie, M., Kimura, J., DeGraffenreid, L., Ajami, S., Duwe, G., Weiss, A., Tsien, R. Expression and function of CD3 on murine thymocytes UCLA Symposia on Molecular and Cellular Biology, New Series 1988 73:33-45
- Allison, J. P., Havran, W. L., Asarnow, D., Tigelaar, R. E., Tucker, P. W., Bonyhadi, M. Gamma-delta-antigen receptors of thy-1+ dendritic epidermal-cells - implications for thymic differentiation Immunologic Research 1988 7:292-302 DOI:10.1007/bf02935534 PMID:2906352
- Fitch, F., Lancki, D., Havran, W. Kochs postulates and the molecular-biology of t-cell function Immunology Today 1988 9:41-43 DOI:10.1016/0167-5699(88)91257-1 PMID:3267168
- Moldwin, R. L., Nau, G. J., Havran, W. L., Lancki, D. W., Fitch, F. W. Anti-l3t4 monoclonal-antibody inhibits t-cell activation by anti-t-cell receptor antibody through a pathway not involving associative recognition Annales de l'Institut Pasteur - Immunology 1987 138:131-134 PMID:3107585
- Moldwin, R. L., Havran, W. L., Nau, G. J., Lancki, D. W., Kim, D. K., Fitch, F. W. Antibodies to the l3t4 and lyt-2 molecules interfere with antigen receptor-driven activation of cloned murine t-cells Journal of Immunology 1987 139:657-664 PMID:2955046
- Havran, W. L., Fitch, F. W. Characterization of murine cytolytic-helper hybrid t-cell clones Nature 1987 325:65-67 DOI:10.1038/325065a0 PMID:2948129
- Havran, W. L., Poenie, M., Kimura, J., Tsien, R., Weiss, A., Allison, J. P. Expression and function of the cd3-antigen receptor on murine cd4+8+ thymocytes Nature 1987 330:170-173 DOI:10.1038/330170a0 PMID:2959867
- Havran, W. L., Kim, D. K., Moldwin, R. L., Lancki, D. W., Fitch, F. W. Interleukin-2 differentially regulates il-2 receptors on murine cloned cytolytic and helper t-cells Clinical Immunology and Immunopathology 1986 39:368-378 DOI:10.1016/0090-1229(86)90165-0 PMID:2938859
- Tripathi, B. J., Tripathi, R. C., Stefansson, K., Havran, W. L., Fitch, F. W. Monoclonal antibodies to human trabecular endothelium. A preliminary report on production and characterization Experimental Eye Research 1986 43:863-866 DOI:10.1016/s0014-4835(86)80016-1 PMID:2433139
- Kim, D. K., Havran, W. L., Moldwin, R. L., Lancki, D. W., Fitch, F. W. IL-2 regulates IL-2 receptor expression on murine T cell clones ICSU Short Reports 1985 2:195-196
- Lancki, D. W., Ma, D. I., Havran, W. L., Fitch, F. W. Cell-surface structures involved in t-cell activation Immunological Reviews 1984 81:65-94 DOI:10.1111/j.1600-065X.1984.tb01105.x PMID:6239820
- Havran, W. L., Digiusto, D. L., Cambier, J. C. Migm-migd ratios on b-cells - mean migd expression exceeds migm by 10-fold on most splenic b-cells Journal of Immunology 1984 132:1712-1716 PMID:6421926
- Dialynas, D. P., Wilde, D. B., Marrack, P., Pierres, A., Wall, K. A., Havran, W., Otten, G., Loken, M. R., Pierres, M., Kappler, J., Fitch, F. W. Characterization of the murine antigenic determinant, designated l3t4a, recognized by monoclonal-antibody gk1.5 - expression of l3t4a by functional t-cell clones appears to correlate primarily with class ii mhc antigen-reactivity Immunological Reviews 1983 74:29-56 DOI:10.1111/j.1600-065X.1983.tb01083.x PMID:6195085
- Monroe, J. G., Havran, W. L., Cambier, J. C. Lymphocyte-b activation - entry into cell-cycle is accompanied by decreased expression of igd but not igm European Journal of Immunology 1983 13:208-213 DOI:10.1002/eji.1830130306 PMID:6601015
- Monroe, J. G., Havran, W. L., Cambier, J. C. Enrichment of viable lymphocytes in defined cycle phases by sorting on the basis of pulse width of axial light extinction Cytometry 1982 3:24-27 DOI:10.1002/cyto.990030107 PMID:6180872
- Cambier, J. C., Havran, W. L., Dealbornoz, T. F., Corley, R. B. Identification of a brain theta-positive, secretory-cell from hematopoietic tissues Journal of Immunology 1981 127:1685-1691 PMID:7196931

featured in

Mysterious gamma delta T Cells Promote Wound Repair Newsletter
Scripps Research Institute Scientists Discover Important Wound-Healing Process News Release
Scripps Research Scientists Find Important Molecular Trigger for Wound-Healing News Release