Scripps VIVO scripps research logo

  • Index
  • Log in
  • Home
  • People
  • Organizations
  • Research
  • Events
Search form
Harrison, Scott Timothy
Display my h-index
Publications in VIVO
 
    Export Publications Table
co-author
Co-author Network
map of science
Map of Science
Biosketch in .docx format  Create Biosketch

Harrison, Scott Timothy

Graduate Student
share the uri qr icon Close

Positions

  • 2018 - Lead Investigator, In Silico Predictive Chemistry, GSK Pharmaceuticals
  • 2006 - Scientist, Merck & Co., Inc.

Websites

  • Doctoral Dissertation
  • Publications
  • Background
  • Contact
  • View All
scroll to property group menus

Publications

recent publications
  • All Publications
  • PubMed Display for Export
  • Publications without PubMed PMIDs

  • academic article

    • Schubert, J. W., Harrison, S. T., Mulhearn, J., Gomez, R., Tynebor, R., Jones, K., Bunda, J., Hanney, B., Wai, J. M. C., Cox, C., McCauley, J. A., Sanders, J. M., et al. Discovery, optimization, and biological characterization of 2,3,6-trisubstituted pyridine-containing M-4 positive allosteric modulators Chemmedchem  2019 14:943-951  DOI:10.1002/cmdc.201900088  PMID:30920765
    • Harrison, S., Lahue, B., Peng, Z., Donofrio, A., Chang, C., Glick, M. Extending 'predict first' to the design-make-test cycle in small-molecule drug discovery Future Medicinal Chemistry  2017 9:533-536  DOI:10.4155/fmc-2017-0025  PMID:28402685
    • Zhao, Z., Harrison, S. T., Schubert, J. W., Sanders, J. M., Polsky-Fisher, S., Zhang, N. R., McLoughlin, D., Gibson, C. R., Robinson, R. G., Sachs, N. A., Kandebo, M., Yao, L., et al. Synthesis and optimization of N-heterocyclic pyridinones as catechol-O-methyltransferase (COMT) inhibitors Bioorganic & Medicinal Chemistry Letters  2016 26:2952-2956  DOI:10.1016/j.bmcl.2016.03.095  PMID:27133481
    • Harrison, S. T., Poslusney, M. S., Mulhearn, J. J., Zhao, Z., Kett, N. R., Schubert, J. W., Melamed, J. Y., Allison, T. J., Patel, S. B., Sanders, J. M., Sharma, S., Smith, R. F., et al. Synthesis and evaluation of heterocyclic catechol mimics as inhibitors of catechol-O-methyltransferase (COMT) ACS Medicinal Chemistry Letters  2015 6:318-323  DOI:10.1021/ml500502d  PMID:25815153  PMCID:PMC4360154
    • Robinson, R. G., Smith, S. M., Wolkenberg, S. E., Kandebo, M., Yao, L., Gibson, C. R., Harrison, S. T., Polsky-Fisher, S., Barrow, J. C., Manley, P. J., Mulhearn, J. J., Nanda, K. K., et al. Characterization of non-nitrocatechol pan and isoform specific catechol-O-methyltransferase inhibitors and substrates ACS Chemical Neuroscience  2012 3:129-140  DOI:10.1021/cn200109w  PMID:22860182  PMCID:PMC3369789
    • Hostetler, E. D., Sanabria-Bohorquez, S., Fan, H., Zeng, Z., Gammage, L., Miller, P., O'Malley, S., Connolly, B., Mulhearn, J., Harrison, S. T., Wolkenberg, S. E., Barrow, J. C., et al. (18)F Fluoroazabenzoxazoles as potential amyloid plaque PET tracers: synthesis and in vivo evaluation in rhesus monkey Nuclear Medicine and Biology  2011 38:1193-1203  DOI:10.1016/j.nucmedbio.2011.04.004  PMID:21741254
    • Wolkenberg, S. E., Zhao, Z., Mulhearn, J. J., Harrison, S. T., Sanders, J. M., Cato, M. J., Jovanovska, A., Panigel, J., Cook, S. P., Henze, D. A., Kane, S. A., Hartman, G. D., et al. High concentration electrophysiology-based fragment screen: discovery of novel acid-sensing ion channel 3 (ASIC3) inhibitors Bioorganic & Medicinal Chemistry Letters  2011 21:2646-2649  DOI:10.1016/j.bmcl.2010.12.115  PMID:21257308
    • Harrison, S. T., Mulhearn, J., Wolkenberg, S. E., Miller, P. J., O'Malley, S. S., Zeng, Z., Williams Jr., D. L., Hostetler, E. D., Sanabria-Bohorquez, S., Gammage, L., Fan, H., Sur, C., et al. Synthesis and evaluation of 5-fluoro-2-aryloxazolo 5,4-b pyridines as beta-amyloid PET ligands and identification of MK-3328 ACS Medicinal Chemistry Letters  2011 2:498-502  DOI:10.1021/ml200018n  PMID:24900338  PMCID:PMC4018077
    • degree-related publication Nicolaou, K. C.*, Harrison, S. T.*, Chen, J. S. Discoveries from the abyss: The abyssomicins and their total synthesis Synthesis-Stuttgart  2009 33-42  DOI:10.1055/s-0028-1083259  PMID:20047014  PMCID:PMC2677807 (* = equal contribution)
    • degree-related publication Nicolaou, K. C.*, Harrison, S. T.* Total synthesis of abyssomicin c, atrop-abyssomicin c, and abyssomicin d: Implications for natural origins of atrop-abyssomicin c Journal of the American Chemical Society  2007 129:429-440  DOI:10.1021/ja067083p  PMID:17212423 (* = equal contribution)
    • degree-related publication Nicolaou, K. C., Denton, R. M., Lenzen, A., Edmonds, D. J., Li, A., Milburn, R. R., Harrison, S. T. Stereocontrolled synthesis of model core systems of lomaiviticins a and b Angewandte Chemie-International Edition  2006 45:2076-2081  DOI:10.1002/anie.200504466  PMID:16496276
    • degree-related publication Nicolaou, K. C.*, Harrison, S. T.* Total synthesis of abyssomicin c and atrop-abyssomicin c Angewandte Chemie-International Edition  2006 45:3256-3260  DOI:10.1002/anie.200601116  PMID:16634106 (* = equal contribution)
    • degree-related publication Nicolaou, K. C.*, Gray, D. L. F.*, Montagnon, T., Harrison, S. T. Oxidation of silyl enol ethers by using IBX and IBX.N-oxide complexes: a mild and selective reaction for the synthesis of enones Angewandte Chemie-International Edition  2002 41:996-1000  DOI:10.1002/1521-3773(20020315)41:6<996::aid-anie996>3.0.co;2-i  PMID:12491292 (* = equal contribution)
scroll to property group menus

Background

education and training

  • Ph.D. in Chemistry, Scripps Research 2001 - 2006
  • B.S. in Chemistry and Biochemistry, University of Michigan 1997 - 2001

advisee of

  • graduate advising relationship

    • Nicolaou, K.C., Ph.D.  candidacy, 2002 - 2006
scroll to property group menus

Contact

full name

  • Scott Timothy Harrison

geographic location

  • Scripps California 

©2019 The Scripps Research Institute | Terms of Use | Powered by VIVO

  • About
  • Contact Us
  • Support