recent publications
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academic article
- Schubert, J. W., Harrison, S. T., Mulhearn, J., Gomez, R., Tynebor, R., Jones, K., Bunda, J., Hanney, B., Wai, J. M. C., Cox, C., McCauley, J. A., Sanders, J. M., et al. Discovery, optimization, and biological characterization of 2,3,6-trisubstituted pyridine-containing M-4 positive allosteric modulators Chemmedchem 2019 14:943-951 DOI:10.1002/cmdc.201900088 PMID:30920765
- Harrison, S., Lahue, B., Peng, Z., Donofrio, A., Chang, C., Glick, M. Extending 'predict first' to the design-make-test cycle in small-molecule drug discovery Future Medicinal Chemistry 2017 9:533-536 DOI:10.4155/fmc-2017-0025 PMID:28402685
- Zhao, Z., Harrison, S. T., Schubert, J. W., Sanders, J. M., Polsky-Fisher, S., Zhang, N. R., McLoughlin, D., Gibson, C. R., Robinson, R. G., Sachs, N. A., Kandebo, M., Yao, L., et al. Synthesis and optimization of N-heterocyclic pyridinones as catechol-O-methyltransferase (COMT) inhibitors Bioorganic & Medicinal Chemistry Letters 2016 26:2952-2956 DOI:10.1016/j.bmcl.2016.03.095 PMID:27133481
- Harrison, S. T., Poslusney, M. S., Mulhearn, J. J., Zhao, Z., Kett, N. R., Schubert, J. W., Melamed, J. Y., Allison, T. J., Patel, S. B., Sanders, J. M., Sharma, S., Smith, R. F., et al. Synthesis and evaluation of heterocyclic catechol mimics as inhibitors of catechol-O-methyltransferase (COMT) ACS Medicinal Chemistry Letters 2015 6:318-323 DOI:10.1021/ml500502d PMID:25815153 PMCID:PMC4360154
- Robinson, R. G., Smith, S. M., Wolkenberg, S. E., Kandebo, M., Yao, L., Gibson, C. R., Harrison, S. T., Polsky-Fisher, S., Barrow, J. C., Manley, P. J., Mulhearn, J. J., Nanda, K. K., et al. Characterization of non-nitrocatechol pan and isoform specific catechol-O-methyltransferase inhibitors and substrates ACS Chemical Neuroscience 2012 3:129-140 DOI:10.1021/cn200109w PMID:22860182 PMCID:PMC3369789
- Hostetler, E. D., Sanabria-Bohorquez, S., Fan, H., Zeng, Z., Gammage, L., Miller, P., O'Malley, S., Connolly, B., Mulhearn, J., Harrison, S. T., Wolkenberg, S. E., Barrow, J. C., et al. (18)F Fluoroazabenzoxazoles as potential amyloid plaque PET tracers: synthesis and in vivo evaluation in rhesus monkey Nuclear Medicine and Biology 2011 38:1193-1203 DOI:10.1016/j.nucmedbio.2011.04.004 PMID:21741254
- Wolkenberg, S. E., Zhao, Z., Mulhearn, J. J., Harrison, S. T., Sanders, J. M., Cato, M. J., Jovanovska, A., Panigel, J., Cook, S. P., Henze, D. A., Kane, S. A., Hartman, G. D., et al. High concentration electrophysiology-based fragment screen: discovery of novel acid-sensing ion channel 3 (ASIC3) inhibitors Bioorganic & Medicinal Chemistry Letters 2011 21:2646-2649 DOI:10.1016/j.bmcl.2010.12.115 PMID:21257308
- Harrison, S. T., Mulhearn, J., Wolkenberg, S. E., Miller, P. J., O'Malley, S. S., Zeng, Z., Williams Jr., D. L., Hostetler, E. D., Sanabria-Bohorquez, S., Gammage, L., Fan, H., Sur, C., et al. Synthesis and evaluation of 5-fluoro-2-aryloxazolo 5,4-b pyridines as beta-amyloid PET ligands and identification of MK-3328 ACS Medicinal Chemistry Letters 2011 2:498-502 DOI:10.1021/ml200018n PMID:24900338 PMCID:PMC4018077
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Nicolaou, K. C.*, Harrison, S. T.*, Chen, J. S.
Discoveries from the abyss: The abyssomicins and their total synthesis
Synthesis-Stuttgart
2009
33-42
DOI:10.1055/s-0028-1083259
PMID:20047014
PMCID:PMC2677807
(* = equal contribution)
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Nicolaou, K. C.*, Harrison, S. T.*
Total synthesis of abyssomicin c, atrop-abyssomicin c, and abyssomicin d: Implications for natural origins of atrop-abyssomicin c
Journal of the American Chemical Society
2007
129:429-440
DOI:10.1021/ja067083p
PMID:17212423
(* = equal contribution)
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Nicolaou, K. C., Denton, R. M., Lenzen, A., Edmonds, D. J., Li, A., Milburn, R. R., Harrison, S. T.
Stereocontrolled synthesis of model core systems of lomaiviticins a and b
Angewandte Chemie-International Edition
2006
45:2076-2081
DOI:10.1002/anie.200504466
PMID:16496276
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Nicolaou, K. C.*, Harrison, S. T.*
Total synthesis of abyssomicin c and atrop-abyssomicin c
Angewandte Chemie-International Edition
2006
45:3256-3260
DOI:10.1002/anie.200601116
PMID:16634106
(* = equal contribution)
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Nicolaou, K. C.*, Gray, D. L. F.*, Montagnon, T., Harrison, S. T.
Oxidation of silyl enol ethers by using IBX and IBX.N-oxide complexes: a mild and selective reaction for the synthesis of enones
Angewandte Chemie-International Edition
2002
41:996-1000
DOI:10.1002/1521-3773(20020315)41:6<996::aid-anie996>3.0.co;2-i
PMID:12491292
(* = equal contribution)