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Hansen, Scott
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Hansen, Scott

Faculty Member
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Positions

  • 2018 - Associate Professor (Joint Appointment), Neuroscience , Scripps Research
  • 2018 - Associate Professor, Molecular Medicine , Scripps Research
  • 2012 - Faculty Member, Skaggs Graduate School of Chemical and Biological Sciences , Scripps Research
  • 2017 - 2018 Assistant Professor, Molecular Medicine , Scripps Research
  • 2012 - 2018 Assistant Professor (Joint Appointment), Neuroscience , Scripps Research
  • 2012 - 2017 Assistant Professor, Molecular Therapeutics , Scripps Research
  • 2000 Research Associate, Scripps Research
  • 1999 - 2000 Laboratory Technician, Abbott Laboratories

Contact

  • shansen@scripps.edu

Websites

  • Scott Hansen, Ph.D.
  • Laboratory Website
  • Publications
  • Teaching
  • Background
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Publications

recent publications
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  • Publications without PubMed PMIDs

  • academic article

    • Wang, H., Kulas, J. A., Wang, C., Holtzman, D. M., Ferris, H. A., Hansen, S. B. Regulation of beta-amyloid production in neurons by cholesterol Proceedings of the National Academy of Sciences of the United States of America  2021 118  DOI:10.1073/pnas.2102191118  PMID:34385305  PMCID:PMC8379952
    • Hansen, S. B., Lerner, R. A., Pavel, M. A., Petersen, E. N. Reply to van Swinderen and Hines: Drosophila model establishes the lipid membrane as a target of anesthetics Proceedings of the National Academy of Sciences of the United States of America  2020 117:24629-24629  DOI:10.1073/pnas.2015732117  PMID:32994344  PMCID:PMC7547279
    • Hauseman, Z. J., Harvey, E. P., Newman, C. E., Wales, T. E., Bucci, J. C., Mintseris, J., Schweppe, D. K., David, L., Fan, L. X., Cohen, D. T., Herce, H. D., Mourtada, R., et al. Homogeneous Oligomers of Pro-apoptotic BAX Reveal Structural Determinants of Mitochondrial Membrane Permeabilization Molecular Cell  2020 79:68-83  DOI:10.1016/j.molcel.2020.05.029  PMID:32533918
    • Pavel, M. A., Petersen, E. N., Wang, H., Lerner, R. A., Hansen, S. B. Studies on the mechanism of general anesthesia Proceedings of the National Academy of Sciences of the United States of America  2020 117:13757-13766  DOI:10.1073/pnas.2004259117  PMID:32467161  PMCID:PMC7306821
    • Petersen, E. N., Pavel, M. A., Wang, H., Hansen, S. B. Disruption of palmitate-mediated localization; a shared pathway of force and anesthetic activation of TREK-1 channels Biochimica Et Biophysica Acta-Biomembranes  2020 1862  DOI:10.1016/j.bbamem.2019.183091  PMID:31672538  PMCID:PMC6907892
    • Pavel, M. A., Chung, H. W., Petersen, E. N., Hansen, S. B. Polymodal mechanism for TWIK-related K+ channel inhibition by local anesthetic Anesthesia and Analgesia  2019 129:973-982  DOI:10.1213/ane.0000000000004216  PMID:31124840
    • Robinson, C. V., Rohacs, T., Hansen, S. B. Tools for understanding nanoscale lipid regulation of ion channels Trends in Biochemical Sciences  2019 44:795-806  DOI:10.1016/j.tibs.2019.04.001  PMID:31060927  PMCID:PMC6729126
    • Chung, H. W., Petersen, E. N., Cabanos, C., Murphy, K. R., Pavel, M. A., Hansen, A. S., Ja, W. W., Hansen, S. B. A molecular target for an alcohol chain-length cutoff Journal of Molecular Biology  2019 431:196-209  DOI:10.1016/j.jmb.2018.11.028  PMID:30529033  PMCID:PMC6360937
    • Cabanos, C., Wang, M., Han, X., Hansen, S. B. A soluble fluorescent binding assay reveals PIP2 antagonism of TREK-1 channels Cell Reports  2017 20:1287-1294  DOI:10.1016/j.celrep.2017.07.034  PMID:28793254
    • Petersen, E. N., Chung, H. W., Nayebosadri, A., Hansen, S. B. Kinetic disruption of lipid rafts is a mechanosensor for phospholipase D Nature Communications  2016 7  DOI:10.1038/ncomms13873  PMID:27976674  PMCID:PMC5171650
    • Hansen, S. B. Lipid agonism: The PIP2 paradigm of ligand-gated ion channels Biochimica et Biophysica Acta-Molecular and Cell Biology of Lipids  2015 1851:620-628  DOI:10.1016/j.bbalip.2015.01.011  PMID:25633344  PMCID:PMC4540326
    • Hansen, S. B., Tao, X., MacKinnon, R. Structural basis of PIP2 activation of the classical inward rectifier K+ channel Kir2.2 Nature  2011 477:495-8  DOI:10.1038/nature10370  PMID:21874019  PMCID:PMC3324908
    • Sine, S. M., Wang, H. L., Hansen, S., Taylor, P. On the origin of ion selectivity in the Cys-loop receptor family Journal of Molecular Neuroscience  2010 40:70-76  DOI:10.1007/s12031-009-9260-1  PMID:19728176  PMCID:PMC3047408
    • Hansen, S. B., Wang, H. L., Taylor, P., Sine, S. M. An ion selectivity filter in the extracellular domain of Cys-loop receptors reveals determinants for ion conductance Journal of Biological Chemistry  2008 283:36066-36070  DOI:10.1074/jbc.C800194200  PMID:18940802  PMCID:PMC2662287
    • Taylor, P., Talley, T. T., Radic, Z., Hansen, S. B., Hibbs, R. E., Shi, J. Structure-guided drug design: Conferring selectivity among neuronal nicotinic receptor and acetylcholine-binding protein subtypes Biochemical Pharmacology  2007 74:1164-1171  DOI:10.1016/j.bcp.2007.07.038  PMID:17826748  PMCID:PMC3341175
    • Hansen, S. B., Taylor, P. Galanthamine and non-competitive inhibitor binding to ACh-binding protein: evidence for a binding site on non-alpha-subunit interfaces of heteromeric neuronal nicotinic receptors Journal of Molecular Biology  2007 369:895-901  DOI:10.1016/j.jmb.2007.03.067  PMID:17481657  PMCID:PMC2031909
    • Gao, F., Mer, G., Tonelli, M., Hansen, S. B., Burghardt, T. P., Taylor, P., Sine, S. M. Solution NMR of acetylcholine binding protein reveals agonist-mediated conformational change of the C-loop Molecular Pharmacology  2006 70:1230-1235  DOI:10.1124/mol.106.027185  PMID:16847142
    • Hansen, S. B., Suizenbacher, G., Huxford, T., Marchot, P., Bourne, Y., Taylor, P. Structural characterization of agonist and antagonist-bound acetylcholine-binding protein from Aplysia californica Journal of Molecular Neuroscience  2006 30:101-102  DOI:10.1385/JMN:30:1:101  PMID:17192647
    • Bourne, Y., Hansen, S. B., Sulzenbacher, G., Talley, T. T., Huxford, T., Taylor, P., Marchot, P. Structural comparison of three crystalline complexes of a peptidic toxin with a synaptic acetylcholine recognition protein Journal of Molecular Neuroscience  2006 30:103-104  DOI:10.1385/JMN:30:1:103  PMID:17192648  PMCID:PMC4755294
    • Hibbs, R. E., Johnson, D. A., Shi, J. X., Hansen, S. B., Taylor, P. Structural dynamics of the alpha-neurotoxin-acetylcholine-binding protein complex: Hydrodynamic and fluorescence anisotropy decay analyses Biochemistry  2005 44:16602-16611  DOI:10.1021/bi051735p  PMID:16342951
    • Hansen, S. B., Sulzenbacher, G., Huxford, T., Marchot, P., Taylor, P., Bourne, Y. Structures of Aplysia AChBP complexes with nicotinic agonists and antagonists reveal distinctive binding interfaces and conformations EMBO Journal  2005 24:3635-3646  DOI:10.1038/sj.emboj.7600828  PMID:16193063  PMCID:PMC1276711
    • Bourne, Y., Talley, T. T., Hansen, S. B., Taylor, P., Marchot, P. Crystal structure of a Cbtx-AChBP complex reveals essential interactions between snake alpha-neurotoxins and nicotinic receptors EMBO Journal  2005 24:1512-1522  DOI:10.1038/sj.emboj.7600620  PMID:15791209  PMCID:PMC1142565
    • Gao, F., Bren, N., Burghardt, T. P., Hansen, S., Henchman, R. H., Taylor, P., McCammon, J. A., Sine, S. M. Agonist-mediated conformational changes in acetylcholine-binding protein revealed by simulation and intrinsic tryptophan fluorescence Journal of Biological Chemistry  2005 280:8443-8451  DOI:10.1074/jbc.M412389200  PMID:15591050
    • Bouzat, C., Gumilar, F., Spitzmaul, G., Wang, H. L., Rayes, D., Hansen, S. B., Taylor, P., Sine, S. M. Coupling of agonist binding to channel gating in an ACh-binding protein linked to an ion channel Nature  2004 430:896-900  DOI:10.1038/nature02753  PMID:15318223
    • Hansen, S. B., Talley, T. T., Radic, Z., Taylor, P. Structural and ligand recognition characteristics of an acetylcholine-binding protein from Aplysia californica Journal of Biological Chemistry  2004 279:24197-24202  DOI:10.1074/jbc.M402452200  PMID:15069068  PMCID:PMC4762456
    • Taylor, P., Hansen, S. B., Talley, T. T., Hibbs, R. E., Radic, Z. Contemporary paradigms for cholinergic ligand design guided by biological structure Bioorganic & Medicinal Chemistry Letters  2004 14:1875-1877  DOI:10.1016/j.bmcl.2003.10.072  PMID:15050619  PMCID:PMC3191913
    • Gao, F., Bren, N., Little, A., Wang, H. L., Hansen, S. B., Talley, T. T., Taylor, P., Sine, S. M. Curariform antagonists bind in different orientations to acetylcholine-binding protein Journal of Biological Chemistry  2003 278:23020-23026  DOI:10.1074/jbc.M301151200  PMID:12682067  PMCID:PMC3191914
    • Hansen, S. B., Radic, Z., Talley, T. T., Molles, B. E., Deerinck, T., Tsigelny, I., Taylor, P. Tryptophan fluorescence reveals conformational changes in the acetylcholine binding protein Journal of Biological Chemistry  2002 277:41299-41302  DOI:10.1074/jbc.C200462200  PMID:12235129  PMCID:PMC3191908

featured in

  • Scripps Florida Scientist Wins Prestigious NIH New Innovator Award  News Release
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Teaching

advisees

  • graduate advising relationship

    • Wang, Hao, Ph.D.  candidate, 2018 -
    • Petersen, Nicholas, Ph.D.  candidate, 2013 - 2018
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Background

education and training

  • Ph.D., University of California, San Diego 2000 - 2006
  • B.S. in Chemistry, Utah State University 1994 - 1999
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Contact

full name

  • Scott B. Hansen

geographic location

  • Scripps Florida 

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