Hansen, Scott

Faculty Member

Positions

2018 - Associate Professor (Joint Appointment), Neuroscience , Scripps Research
2018 - Associate Professor, Molecular Medicine , Scripps Research
2012 - Faculty Member, Skaggs Graduate School of Chemical and Biological Sciences , Scripps Research
2017 - 2018 Assistant Professor, Molecular Medicine , Scripps Research
2012 - 2018 Assistant Professor (Joint Appointment), Neuroscience , Scripps Research
2012 - 2017 Assistant Professor, Molecular Therapeutics , Scripps Research
2000 Research Associate, Scripps Research
1999 - 2000 Laboratory Technician, Abbott Laboratories

Contact

shansen@scripps.edu

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recent publications

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academic article
- Chung, H. W., Petersen, E. N., Cabanos, C., Murphy, K. R., Pavel, M. A., Hansen, A. S., Ja, W. W., Hansen, S. B. A molecular target for an alcohol chain-length cutoff Journal of Molecular Biology 2019 431:196-209 DOI:10.1016/j.jmb.2018.11.028 PMID:30529033 PMCID:PMC6360937
- Pavel, M. A., Chung, H. W., Petersen, E. N., Hansen, S. B. Polymodal mechanism for TWIK-related K+ channel inhibition by local anesthetic Anesthesia and Analgesia 2019 129:973-982 DOI:10.1213/ane.0000000000004216 PMID:31124840
- Robinson, C. V., Rohacs, T., Hansen, S. B. Tools for understanding nanoscale lipid regulation of ion channels Trends in Biochemical Sciences 2019 44:795-806 DOI:10.1016/j.tibs.2019.04.001 PMID:31060927 PMCID:PMC6729126
- Cabanos, C., Wang, M., Han, X., Hansen, S. B. A soluble fluorescent binding assay reveals PIP2 antagonism of TREK-1 channels Cell Reports 2017 20:1287-1294 DOI:10.1016/j.celrep.2017.07.034 PMID:28793254
- Petersen, E. N., Chung, H. W., Nayebosadri, A., Hansen, S. B. Kinetic disruption of lipid rafts is a mechanosensor for phospholipase D Nature Communications 2016 7 DOI:10.1038/ncomms13873 PMID:27976674 PMCID:PMC5171650
- Hansen, S. B. Lipid agonism: The PIP2 paradigm of ligand-gated ion channels Biochimica et Biophysica Acta-Molecular and Cell Biology of Lipids 2015 1851:620-628 DOI:10.1016/j.bbalip.2015.01.011 PMID:25633344 PMCID:PMC4540326
- Hansen, S. B., Tao, X., MacKinnon, R. Structural basis of PIP2 activation of the classical inward rectifier K+ channel Kir2.2 Nature 2011 477:495-8 DOI:10.1038/nature10370 PMID:21874019 PMCID:PMC3324908
- Sine, S. M., Wang, H. L., Hansen, S., Taylor, P. On the origin of ion selectivity in the Cys-loop receptor family Journal of Molecular Neuroscience 2010 40:70-76 DOI:10.1007/s12031-009-9260-1 PMID:19728176 PMCID:PMC3047408
- Hansen, S. B., Wang, H. L., Taylor, P., Sine, S. M. An ion selectivity filter in the extracellular domain of Cys-loop receptors reveals determinants for ion conductance Journal of Biological Chemistry 2008 283:36066-36070 DOI:10.1074/jbc.C800194200 PMID:18940802 PMCID:PMC2662287
- Hansen, S. B., Taylor, P. Galanthamine and non-competitive inhibitor binding to ACh-binding protein: evidence for a binding site on non-alpha-subunit interfaces of heteromeric neuronal nicotinic receptors Journal of Molecular Biology 2007 369:895-901 DOI:10.1016/j.jmb.2007.03.067 PMID:17481657 PMCID:PMC2031909
- Taylor, P., Talley, T. T., Radic, Z., Hansen, S. B., Hibbs, R. E., Shi, J. Structure-guided drug design: Conferring selectivity among neuronal nicotinic receptor and acetylcholine-binding protein subtypes Biochemical Pharmacology 2007 74:1164-1171 DOI:10.1016/j.bcp.2007.07.038 PMID:17826748 PMCID:PMC3341175
- Gao, F., Mer, G., Tonelli, M., Hansen, S. B., Burghardt, T. P., Taylor, P., Sine, S. M. Solution NMR of acetylcholine binding protein reveals agonist-mediated conformational change of the C-loop Molecular Pharmacology 2006 70:1230-1235 DOI:10.1124/mol.106.027185 PMID:16847142
- Hansen, S. B., Suizenbacher, G., Huxford, T., Marchot, P., Bourne, Y., Taylor, P. Structural characterization of agonist and antagonist-bound acetylcholine-binding protein from Aplysia californica Journal of Molecular Neuroscience 2006 30:101-102 DOI:10.1385/JMN:30:1:101 PMID:17192647
- Bourne, Y., Hansen, S. B., Sulzenbacher, G., Talley, T. T., Huxford, T., Taylor, P., Marchot, P. Structural comparison of three crystalline complexes of a peptidic toxin with a synaptic acetylcholine recognition protein Journal of Molecular Neuroscience 2006 30:103-104 DOI:10.1385/JMN:30:1:103 PMID:17192648 PMCID:PMC4755294
- Gao, F., Bren, N., Burghardt, T. P., Hansen, S., Henchman, R. H., Taylor, P., McCammon, J. A., Sine, S. M. Agonist-mediated conformational changes in acetylcholine-binding protein revealed by simulation and intrinsic tryptophan fluorescence Journal of Biological Chemistry 2005 280:8443-8451 DOI:10.1074/jbc.M412389200 PMID:15591050
- Bourne, Y., Talley, T. T., Hansen, S. B., Taylor, P., Marchot, P. Crystal structure of a Cbtx-AChBP complex reveals essential interactions between snake alpha-neurotoxins and nicotinic receptors EMBO Journal 2005 24:1512-1522 DOI:10.1038/sj.emboj.7600620 PMID:15791209 PMCID:PMC1142565
- Hibbs, R. E., Johnson, D. A., Shi, J. X., Hansen, S. B., Taylor, P. Structural dynamics of the alpha-neurotoxin-acetylcholine-binding protein complex: Hydrodynamic and fluorescence anisotropy decay analyses Biochemistry 2005 44:16602-16611 DOI:10.1021/bi051735p PMID:16342951
- Hansen, S. B., Sulzenbacher, G., Huxford, T., Marchot, P., Taylor, P., Bourne, Y. Structures of Aplysia AChBP complexes with nicotinic agonists and antagonists reveal distinctive binding interfaces and conformations EMBO Journal 2005 24:3635-3646 DOI:10.1038/sj.emboj.7600828 PMID:16193063 PMCID:PMC1276711
- Taylor, P., Hansen, S. B., Talley, T. T., Hibbs, R. E., Radic, Z. Contemporary paradigms for cholinergic ligand design guided by biological structure Bioorganic & Medicinal Chemistry Letters 2004 14:1875-1877 DOI:10.1016/j.bmcl.2003.10.072 PMID:15050619 PMCID:PMC3191913
- Bouzat, C., Gumilar, F., Spitzmaul, G., Wang, H. L., Rayes, D., Hansen, S. B., Taylor, P., Sine, S. M. Coupling of agonist binding to channel gating in an ACh-binding protein linked to an ion channel Nature 2004 430:896-900 DOI:10.1038/nature02753 PMID:15318223
- Hansen, S. B., Talley, T. T., Radic, Z., Taylor, P. Structural and ligand recognition characteristics of an acetylcholine-binding protein from Aplysia californica Journal of Biological Chemistry 2004 279:24197-24202 DOI:10.1074/jbc.M402452200 PMID:15069068 PMCID:PMC4762456
- Gao, F., Bren, N., Little, A., Wang, H. L., Hansen, S. B., Talley, T. T., Taylor, P., Sine, S. M. Curariform antagonists bind in different orientations to acetylcholine-binding protein Journal of Biological Chemistry 2003 278:23020-23026 DOI:10.1074/jbc.M301151200 PMID:12682067 PMCID:PMC3191914
- Hansen, S. B., Radic, Z., Talley, T. T., Molles, B. E., Deerinck, T., Tsigelny, I., Taylor, P. Tryptophan fluorescence reveals conformational changes in the acetylcholine binding protein Journal of Biological Chemistry 2002 277:41299-41302 DOI:10.1074/jbc.C200462200 PMID:12235129 PMCID:PMC3191908

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