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Hangartner, Lars
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Hangartner, Lars

Faculty Member
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Positions

  • 2017 - Associate Professor of Immunology and Microbiology, Immunology and Microbiology , Scripps Research
  • 2015 - 2017 Associate Professor, Immunology and Microbial Science (IMS) , Scripps Research
  • 2009 - 2015 Professor SNSF, Institute of Medical Virology , University of Zurich
  • 2008 - 2009 Staff Scientist, University of Zurich
  • 2005 - 2008 Senior Research Associate, Scripps Research
  • 2002 - 2005 Postdoctoral Fellow, University Hospital Zurich

Contact

  • lhangart@scripps.edu

Websites

  • Lars Hangartner, Ph.D.
  • Publications
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  • Identity
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Publications

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  • 21

recent publications
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  • academic article

    • Nogal, B., Bianchi, M., Cottrell, C. A., Kirchdoerfer, R. N., Sewall, L. M., Turner, H. L., Zhao, F., Sok, D., Burton, D. R., Hangartner, L., Ward, A. B. Mapping polyclonal antibody responses in non-human primates vaccinated with HIV env trimer subunit vaccines Cell Reports  2020 30:3755-3765  DOI:10.1016/j.celrep.2020.02.061  PMID:32187547  PMCID:PMC7153566
    • Alter, G., Yu, W. H., Chandrashekar, A., Borducchi, E. N., Ghneim, K., Sharma, A., Nedellec, R., McKenney, K. R., Linde, C., Broge, T., Suscovich, T. J., Linnekin, T., et al. Passive Transfer of Vaccine-Elicited Antibodies Protects against SIV in Rhesus Macaques Cell  2020 183:185-196  DOI:10.1016/j.cell.2020.08.033  PMID:33007262  PMCID:PMC7534693
    • Hangartner, L. Public endowment of B cells Immunity  2019 51:601-603  DOI:10.1016/j.immuni.2019.09.016  PMID:31618651
    • Voss, J. E., Gonzalez-Martin, A., Andrabi, R., Fuller, R. P., Murrell, B., McCoy, L. E., Porter, K., Huang, D., Li, W., Sok, D., Le, K., Briney, B., et al. Reprogramming the antigen specificity of B cells using genome-editing technologies Elife  2019 8  DOI:10.7554/eLife.42995  PMID:30648968  PMCID:PMC6355199
    • Pauthner, M. G., Nkolola, J. P., Havenar-Daughton, C., Murrell, B., Reiss, S. M., Bastidas, R., Prevost, J., Nedellec, R., von Bredow, B., Abbink, P., Cottrell, C. A., Kulp, D. W., et al. Vaccine-induced protection from homologous tier 2 SHIV challenge in nonhuman primates depends on serum-neutralizing antibody titers Immunity  2019 50:241-252  DOI:10.1016/j.immuni.2018.11.011  PMID:30552025  PMCID:PMC6335502
    • Bianchi, M., Turner, H. L., Nogal, B., Cottrell, C. A., Oyen, D., Pauthner, M., Bastidas, R., Nedellec, R., McCoy, L. E., Wilson, I. A., Burton, D. R., Ward, A. B., et al. Electron-microscopy-based epitope mapping defines specificities of polyclonal antibodies elicited during HIV-1 BG505 envelope trimer immunization Immunity  2018 49:288-300  DOI:10.1016/j.immuni.2018.07.009  PMID:30097292  PMCID:PMC6104742
    • Maurer, M. A., Meyer, L., Bianchi, M., Turner, H. L., Le, N. P. L., Steck, M., Wyrzucki, A., Orlowski, V., Ward, A. B., Crispin, M., Hangartner, L. Glycosylation of human IgA directly inhibits influenza A and other sialic-acid-binding viruses Cell Reports  2018 23:90-99  DOI:10.1016/j.celrep.2018.03.027  PMID:29617676
    • Burton, D. R., Hangartner, L. Broadly neutralizing antibodies to HIV and their role in vaccine design Annual Review of Immunology  2016 34:635-659  DOI:10.1146/annurev-immunol-041015-055515  PMID:27168247
    • Kohler, I., Kouyos, R., Bianchi, M., Grube, C., Wyrzucki, A., Gunthard, H. F., Hangartner, L. The impact of vaccination on the breadth and magnitude of the antibody response to influenza A viruses in HIV-infected individuals AIDS  2015 29:1803-1810  DOI:10.1097/qad.0000000000000772  PMID:26372386
    • Wyrzucki, A., Bianchi, M., Kohler, I., Steck, M., Hangartner, L. Heterosubtypic antibodies to influenza A virus have limited activity against cell-bound virus but are not impaired by strain-specific serum antibodies Journal of Virology  2015 89:3136-3144  DOI:10.1128/jvi.03069-14  PMID:25552718  PMCID:PMC4337524
    • Kohler, I., Scherrer, A. U., Zagordi, O., Bianchi, M., Wyrzucki, A., Steck, M., Ledergerber, B., Gunthard, H. F., Hangartner, L. Prevalence and predictors for homo- and heterosubtypic antibodies against influenza A virus. Clinical Infectious Diseases  2014 59:1386-1393  DOI:10.1093/cid/ciu660  PMID:25139962
    • Wyrzucki, A., Dreyfus, C., Kohler, I., Steck, M., Wilson, I. A., Hangartner, L. Alternative recognition of the conserved stem epitope in influenza A virus hemagglutinin by a VH3-30-encoded heterosubtypic antibody Journal of Virology  2014 88:7083-7092  DOI:10.1128/jvi.00178-14  PMID:24719426  PMCID:PMC4054347
    • Hoot, S., McGuire, A. T., Cohen, K. W., Strong, R. K., Hangartner, L., Klein, F., Diskin, R., Scheid, J. F., Sather, D. N., Burton, D. R., Stamatatos, L. Recombinant HIV envelope proteins fail to engage germline versions of anti-CD4bs bNAbs. PLoS Pathogens  2013 9:e1003106  DOI:10.1371/journal.ppat.1003106  PMID:23300456  PMCID:PMC3536657
    • Ota, T., Doyle-Cooper, C., Cooper, A. B., Huber, M., Falkowska, E., Doores, K. J., Hangartner, L., Le, K., Sok, D., Jardine, J., Lifson, J., Wu, X. L., et al. Anti-HIV B Cell lines as candidate vaccine biosensors Journal of Immunology  2012 189:4816-4824  DOI:10.4049/jimmunol.1202165  PMID:23066156  PMCID:PMC3626558
    • Hessell, A. J., Poignard, P., Hunter, M., Tehrani, D. M., Bleeker, W. K., Parren, Pwhi, Marx, P. A., Burton, D. R., Hangartner, L. Effective, low-titer antibody protection against low-dose repeated mucosal shiv challenge in macaques Nature Medicine  2009 15:951-954  DOI:10.1038/nm.1974  PMID:19525965  PMCID:PMC4334439
    • Hessell, A. J., Rakasz, E. G., Poignard, P., Hangartner, L., Landucci, G., Forthal, D. N., Koff, W. C., Watkins, D. I., Burton, D. R. Broadly neutralizing human anti-HIV antibody 2G12 is effective in protection against mucosal SHIV challenge even at low serum neutralizing titers PLoS Pathogens  2009 5:e1000433  DOI:10.1371/journal.ppat.1000433  PMID:19436712  PMCID:PMC2674935
    • Geuking, M. B., Weber, J., Dewannieux, M., Gorelik, E., Heidmann, T., Hengartner, H., Zinkernagel, R. M., Hangartner, L. Recombination of retrotransposon and exogenous RNA virus results in nonretroviral cDNA integration Science  2009 323:393-396  DOI:10.1126/science.1167375  PMID:19150848
    • Law, M., Hangartner, L. Antibodies against viruses: passive and active immunization Current Opinion in Immunology  2008 20:486-492  DOI:10.1016/j.coi.2008.06.005  PMID:18577455  PMCID:PMC2730944
    • Schildknecht, A., Welti, S., Geuking, M. B., Hangartner, L., van den Broek, M. Absence of CTL responses to early viral antigens facilitates viral persistence Journal of Immunology  2008 180:3113-3121  PMID:18292534
    • Recher, M., Lang, K. S., Navarini, A., Hunziker, L., Lang, P. A., Fink, K., Freigang, S., Georgiev, P., Hangartner, L., Zellweger, R., Bergthaler, A., Hegazy, A. N., et al. Extralymphatic virus sanctuaries as a consequence of potent T-cell activation Nature Medicine  2007 13:1316-1323  DOI:10.1038/nm1670  PMID:17982463
    • Zuniga, A., Wang, Z., Liniger, M., Hangartner, L., Caballero, M., Pavlovic, J., Wild, P., Viret, J. F., Glueck, R., Billeter, M. A., Naim, H. Y. Attenuated measles virus as a vaccine vector Vaccine  2007 25:2974-2983  DOI:10.1016/j.vaccine.2007.01.064  PMID:17303293  PMCID:PMC3707277
    • Hessell, A. J., Hangartner, L., Hunter, M., Havenith, C. E. G., Beurskens, F. J., Bakker, J. M., Lanigan, C. M. S., Landucci, G., Forthal, D. N., Parren, Pwhi, Marx, P. A., Burton, D. R. Fc receptor but not complement binding is important in antibody protection against HIV Nature  2007 449:101-104  DOI:10.1038/nature06106  PMID:17805298
    • Zellweger, R. M., Hangartner, L., Weber, J., Zinkernagel, R. M., Hengartner, H. Parameters governing exhaustion of rare T cell-independent neutralizing IgM-producing B cells after LCMV infection European Journal of Immunology  2006 36:3175-3185  DOI:10.1002/eji.200636087  PMID:17125146
    • Hangartner, L., Zellweger, R. M., Giobbi, M., Weber, J., Eschli, B., McCoy, K. D., Harris, N., Recher, M., Zinkernagel, R. M., Hengartner, H. Nonneutralizing antibodies binding to the surface glycoprotein of lymphocytic choriomeningitis virus reduce early virus spread Journal of Experimental Medicine  2006 203:2033-2042  DOI:10.1084/jem.20051557  PMID:16880253  PMCID:PMC2118372
    • Hangartner, L., Zinkernagel, R. M., Hengartner, H. Antiviral antibody responses: the two extremes of a wide spectrum Nature Reviews Immunology  2006 6:231-243  DOI:10.1038/nri1783  PMID:16498452
    • McCoy, K. D., Harris, N. L., Diener, P., Hatak, S., Odermatt, B., Hangartner, L., Senn, B. M., Marsland, B. J., Geuking, M. B., Hengartner, H., Macpherson, A. J. S., Zinkernagel, R. M. Natural IgE production in the absence of MHC class II cognate help Immunity  2006 24:329-339  DOI:10.1016/j.immuni.2006.01.013  PMID:16546101
    • Recher, M., Lang, K. S., Hunziker, L., Freigang, S., Eschli, B., Harris, N. L., Navarini, A., Senn, B. M., Fink, K., Lotscher, M., Hangartner, L., Zellweger, R., et al. Deliberate removal of T cell help improves virus-neutralizing antibody production Nature Immunology  2004 5:934-942  DOI:10.1038/ni1102  PMID:15300247
    • Hangartner, L., Senn, B. M., Ledermann, B., Kalinke, U., Seiler, P., Bucher, E., Zellweger, R. M., Fink, K., Odermatt, B., Burki, K., Zinkernagel, R. M., Hengartner, H. Antiviral immune responses in gene-targeted mice expressing the immunoglobulin heavy chain of virus-neutralizing antibodies Proceedings of the National Academy of Sciences of the United States of America  2003 100:12883-12888  DOI:10.1073/pnas.2135542100  PMID:14569006  PMCID:PMC240713
    • Wang, Z., Hangartner, L., Cornu, T. I., Martin, L. R., Zuniga, A., Billeter, M. A., Naim, H. Y. Recombinant measles viruses expressing heterologous antigens of mumps and simian immunodeficiency viruses Vaccine  2001 19:2329-2336  DOI:10.1016/s0264-410x(00)00523-5  PMID:11257357
    • Duprex, W. P., McQuaid, S., Hangartner, L., Billeter, M. A., Rima, B. K. Observation of measles virus cell-to-cell spread in astrocytoma cells by using a green fluorescent protein-expressing recombinant virus Journal of Virology  1999 73:9568-9575  PMID:10516065  PMCID:PMC112991
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Background

education and training

  • Ph.D., Eidgenössische Technische Hochschule 1998 - 2002
  • Diploma in Molecular Biology, University of Zurich 1996 - 1997
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Contact

full name

  • Lars Hangartner

geographic location

  • Scripps California 
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Identity

ResearcherID (Thomson Reuters)

  • H-3503-2011

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