recent publications
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academic article
- Xu, Z., Lo, W. S., Beck, D. B., Schuch, L. A., Olahova, M., Kopajtich, R., Chong, Y. E., Alston, C. L., Seidl, E., Zhai, L., Lau, C. F., Timchak, D., et al. Bi-allelic mutations in phe-tRNA synthetase associated with a multi-system pulmonary disease Support non-translational function American Journal of Human Genetics 2018 103:100-114 DOI:10.1016/j.ajhg.2018.06.006 PMID:29979980 PMCID:PMC6035289
- Wei, Z., Xu, Z., Liu, X., Lo, W. S., Ye, F., Lau, C. F., Wang, F., Zhou, J. J., Nangle, L. A., Yang, X. L., Zhang, M., Schimmel, P. Alternative splicing creates two new architectures for human tyrosyl-tRNA synthetase Nucleic Acids Research 2016 44:1247-1255 DOI:10.1093/nar/gkw002 PMID:26773056 PMCID:PMC4756856
- Liu, Y., Satz, J. S., Vo, M. N., Nangle, L. A., Schimmel, P., Ackerman, S. L. Deficiencies in tRNA synthetase editing activity cause cardioproteinopathy Proceedings of the National Academy of Sciences of the United States of America 2014 111:17570-17575 DOI:10.1073/pnas.1420196111 PMID:25422440 PMCID:PMC4267364
- Lo, W. S., Gardiner, E., Xu, Z., Lau, C. F., Wang, F., Zhou, J. J., Mendlein, J. D., Nangle, L. A., Chiang, K. P., Yang, X. L., Au, K. F., Wong, W. H., et al. Human tRNA synthetase catalytic nulls with diverse functions Science 2014 345:328-332 DOI:10.1126/science.1252943 PMID:25035493 PMCID:PMC4188629
- Zhou, J. J., Wang, F., Xu, Z., Lo, W. S., Lau, C. F., Chiang, K. P., Nangle, L. A., Ashlock, M. A., Mendlein, J. D., Yang, X. L., Zhang, M., Schimmel, P. Secreted histidyl-tRNA synthetase splice variants elaborate major epitopes for autoantibodies in inflammatory myositis Journal of Biological Chemistry 2014 289:19269-19275 DOI:10.1074/jbc.C114.571026 PMID:24898250 PMCID:PMC4094037
- Wang, F., Xu, Z., Zhou, J., Lo, W. S., Lau, C. F., Nangle, L. A., Yang, X. L., Zhang, M., Schimmel, P. Regulated capture by exosomes of mRNAs for cytoplasmic tRNA synthetases Journal of Biological Chemistry 2013 288:29223-29228 DOI:10.1074/jbc.C113.490599 PMID:24003230 PMCID:PMC3795223
- Xu, Z. W., Wei, Z. Y., Zhou, J. J., Ye, F., Lo, W. S., Wang, F., Lau, C. F., Wu, J. J., Nangle, L. A., Chiang, K. P., Yang, X. L., Zhang, M. J., et al. Internally deleted human tRNA synthetase suggests evolutionary pressure for repurposing Structure 2012 20:1470-1477 DOI:10.1016/j.str.2012.08.001 PMID:22958643 PMCID:PMC3485694
- Zhou, Q. S., Kapoor, M., Guo, M., Belani, R., Xu, X. L., Kiosses, W. B., Hanan, M., Park, C., Armour, E., Do, M. H., Nangle, L. A., Schimmel, P., et al. Orthogonal use of a human tRNA synthetase active site to achieve multifunctionality Nature Structural & Molecular Biology 2010 17:57-61 DOI:10.1038/nsmb.1706 PMID:20010843 PMCID:PMC3042952
- Storkebaum, E., Leitao-Goncalves, R., Godenschwege, T., Nangle, L., Mejia, M., Bosmans, I., Ooms, T., Jacobs, A., Van Dijck, P., Yang, X. L., Schimmel, P., Norga, K., et al. Dominant mutations in the tyrosyl-tRNA synthetase gene recapitulate in Drosophila features of human Charcot-Marie-Tooth neuropathy Proceedings of the National Academy of Sciences of the United States of America 2009 106:11782-11787 DOI:10.1073/pnas.0905339106 PMID:19561293 PMCID:PMC2702257
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Nangle, L. A., Zhang, W., Xie, W., Yang, X. L., Schimmel, P.
Charcot-Marie-Tooth disease-associated mutant tRNA synthetases linked to altered dimer interface and neurite distribution defect
Proceedings of the National Academy of Sciences of the United States of America
2007
104:11239-11244
DOI:10.1073/pnas.0705055104
PMID:17595294
PMCID:PMC2040883
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Xie, W., Nangle, L. A., Zhang, W., Schimmel, P., Yang, X. L.
Long-range structural effects of a Charcot-Marie-Tooth disease-causing mutation in human glycyl-tRNA synthetase
Proceedings of the National Academy of Sciences of the United States of America
2007
104:9976-9981
DOI:10.1073/pnas.0703908104
PMID:17545306
PMCID:PMC1891255
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Seburn, K. L., Nangle, L. A., Cox, G. A., Schimmel, P., Burgess, R. W.
An active dominant mutation of glycyl-tRNA synthetase causes neuropathy in a Charcot-Marie-Tooth 2D mouse model
Neuron
2006
51:715-726
DOI:10.1016/j.neuron.2006.08.027
PMID:16982418
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Lee, J. W., Beebe, K., Nangle, L. A., Jang, J. S., Longo-Guess, C. M., Cook, S. A., Davisson, M. T., Sundberg, J. P., Schimmel, P., Ackerman, S. L.
Editing-defective tRNA synthetase causes protein misfolding and neurodegeneration
Nature
2006
443:50-55
DOI:10.1038/nature05096
PMID:16906134
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Nangle, L. A., Motta, C. M., Schimmel, P.
Global effects of mistranslation from an editing defect in mammalian cells
Chemistry & Biology
2006
13:1091-1100
DOI:10.1016/j.chembiol.2006.08.011
PMID:17052613
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Nangle, L. A., Lagardt, V. D., Dodring, V., Schimmel, P.
Genetic code ambiguity. Cell viability related to the severity of editing defects in mutant tRNA synthetases
Journal of Biological Chemistry
2002
277:45729-45733
DOI:10.1074/jbc.M208093200
PMID:12244062
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Doring, V., Mootz, H. D., Nangle, L. A., Hendrickson, T. L., de Crecy-Lagard, V., Schimmel, P., Marliere, P.
Enlarging the amino acid set of Escherichia coli by infiltration of the valine coding pathway
Science
2001
292:501-504
DOI:10.1126/science.1057718
PMID:11313495
- Wickert, S., Nangle, L., Shevel, S., Orias, E. Tetrahymena macronuclear genome mapping: colinearity of macronuclear coassortment groups and the micronuclear map on chromosome 1L Genetics 2000 154:1155-1167 PMID:10757760 PMCID:PMC1460982