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Nangle, Leslie
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Nangle, Leslie

Graduate Student
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Positions

  • 2016 - Director, Discovery Biology, aTyr Pharma
  • 2009 - 2016 Associate Director, Discovery Biology, aTyr Pharma
  • 2006 - 2009 Senior Scientist, aTyr Pharma

Websites

  • Doctoral Dissertation
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Publications

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  • academic article

    • Xu, Z., Lo, W. S., Beck, D. B., Schuch, L. A., Olahova, M., Kopajtich, R., Chong, Y. E., Alston, C. L., Seidl, E., Zhai, L., Lau, C. F., Timchak, D., et al. Bi-allelic mutations in phe-tRNA synthetase associated with a multi-system pulmonary disease Support non-translational function American Journal of Human Genetics  2018 103:100-114  DOI:10.1016/j.ajhg.2018.06.006  PMID:29979980  PMCID:PMC6035289
    • Wei, Z., Xu, Z., Liu, X., Lo, W. S., Ye, F., Lau, C. F., Wang, F., Zhou, J. J., Nangle, L. A., Yang, X. L., Zhang, M., Schimmel, P. Alternative splicing creates two new architectures for human tyrosyl-tRNA synthetase Nucleic Acids Research  2016 44:1247-1255  DOI:10.1093/nar/gkw002  PMID:26773056  PMCID:PMC4756856
    • Liu, Y., Satz, J. S., Vo, M. N., Nangle, L. A., Schimmel, P., Ackerman, S. L. Deficiencies in tRNA synthetase editing activity cause cardioproteinopathy Proceedings of the National Academy of Sciences of the United States of America  2014 111:17570-17575  DOI:10.1073/pnas.1420196111  PMID:25422440  PMCID:PMC4267364
    • Lo, W. S., Gardiner, E., Xu, Z., Lau, C. F., Wang, F., Zhou, J. J., Mendlein, J. D., Nangle, L. A., Chiang, K. P., Yang, X. L., Au, K. F., Wong, W. H., et al. Human tRNA synthetase catalytic nulls with diverse functions Science  2014 345:328-332  DOI:10.1126/science.1252943  PMID:25035493  PMCID:PMC4188629
    • Zhou, J. J., Wang, F., Xu, Z., Lo, W. S., Lau, C. F., Chiang, K. P., Nangle, L. A., Ashlock, M. A., Mendlein, J. D., Yang, X. L., Zhang, M., Schimmel, P. Secreted histidyl-tRNA synthetase splice variants elaborate major epitopes for autoantibodies in inflammatory myositis Journal of Biological Chemistry  2014 289:19269-19275  DOI:10.1074/jbc.C114.571026  PMID:24898250  PMCID:PMC4094037
    • Wang, F., Xu, Z., Zhou, J., Lo, W. S., Lau, C. F., Nangle, L. A., Yang, X. L., Zhang, M., Schimmel, P. Regulated capture by exosomes of mRNAs for cytoplasmic tRNA synthetases Journal of Biological Chemistry  2013 288:29223-29228  DOI:10.1074/jbc.C113.490599  PMID:24003230  PMCID:PMC3795223
    • Xu, Z. W., Wei, Z. Y., Zhou, J. J., Ye, F., Lo, W. S., Wang, F., Lau, C. F., Wu, J. J., Nangle, L. A., Chiang, K. P., Yang, X. L., Zhang, M. J., et al. Internally deleted human tRNA synthetase suggests evolutionary pressure for repurposing Structure  2012 20:1470-1477  DOI:10.1016/j.str.2012.08.001  PMID:22958643  PMCID:PMC3485694
    • Zhou, Q. S., Kapoor, M., Guo, M., Belani, R., Xu, X. L., Kiosses, W. B., Hanan, M., Park, C., Armour, E., Do, M. H., Nangle, L. A., Schimmel, P., et al. Orthogonal use of a human tRNA synthetase active site to achieve multifunctionality Nature Structural & Molecular Biology  2010 17:57-61  DOI:10.1038/nsmb.1706  PMID:20010843  PMCID:PMC3042952
    • Storkebaum, E., Leitao-Goncalves, R., Godenschwege, T., Nangle, L., Mejia, M., Bosmans, I., Ooms, T., Jacobs, A., Van Dijck, P., Yang, X. L., Schimmel, P., Norga, K., et al. Dominant mutations in the tyrosyl-tRNA synthetase gene recapitulate in Drosophila features of human Charcot-Marie-Tooth neuropathy Proceedings of the National Academy of Sciences of the United States of America  2009 106:11782-11787  DOI:10.1073/pnas.0905339106  PMID:19561293  PMCID:PMC2702257
    • degree-related publication Nangle, L. A., Zhang, W., Xie, W., Yang, X. L., Schimmel, P. Charcot-Marie-Tooth disease-associated mutant tRNA synthetases linked to altered dimer interface and neurite distribution defect Proceedings of the National Academy of Sciences of the United States of America  2007 104:11239-11244  DOI:10.1073/pnas.0705055104  PMID:17595294  PMCID:PMC2040883
    • degree-related publication Xie, W., Nangle, L. A., Zhang, W., Schimmel, P., Yang, X. L. Long-range structural effects of a Charcot-Marie-Tooth disease-causing mutation in human glycyl-tRNA synthetase Proceedings of the National Academy of Sciences of the United States of America  2007 104:9976-9981  DOI:10.1073/pnas.0703908104  PMID:17545306  PMCID:PMC1891255
    • degree-related publication Nangle, L. A., Motta, C. M., Schimmel, P. Global effects of mistranslation from an editing defect in mammalian cells Chemistry & Biology  2006 13:1091-1100  DOI:10.1016/j.chembiol.2006.08.011  PMID:17052613
    • degree-related publication Seburn, K. L., Nangle, L. A., Cox, G. A., Schimmel, P., Burgess, R. W. An active dominant mutation of glycyl-tRNA synthetase causes neuropathy in a Charcot-Marie-Tooth 2D mouse model Neuron  2006 51:715-726  DOI:10.1016/j.neuron.2006.08.027  PMID:16982418
    • degree-related publication Lee, J. W., Beebe, K., Nangle, L. A., Jang, J. S., Longo-Guess, C. M., Cook, S. A., Davisson, M. T., Sundberg, J. P., Schimmel, P., Ackerman, S. L. Editing-defective tRNA synthetase causes protein misfolding and neurodegeneration Nature  2006 443:50-55  DOI:10.1038/nature05096  PMID:16906134
    • degree-related publication Nangle, L. A., Lagardt, V. D., Dodring, V., Schimmel, P. Genetic code ambiguity. Cell viability related to the severity of editing defects in mutant tRNA synthetases Journal of Biological Chemistry  2002 277:45729-45733  DOI:10.1074/jbc.M208093200  PMID:12244062
    • degree-related publication Doring, V., Mootz, H. D., Nangle, L. A., Hendrickson, T. L., de Crecy-Lagard, V., Schimmel, P., Marliere, P. Enlarging the amino acid set of Escherichia coli by infiltration of the valine coding pathway Science  2001 292:501-504  DOI:10.1126/science.1057718  PMID:11313495
    • Wickert, S., Nangle, L., Shevel, S., Orias, E. Tetrahymena macronuclear genome mapping: colinearity of macronuclear coassortment groups and the micronuclear map on chromosome 1L Genetics  2000 154:1155-1167  PMID:10757760  PMCID:PMC1460982
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Background

education and training

  • Ph.D. in Biology, Scripps Research 2001 - 2006
  • B.S. in Biological Sciences, University of California, Santa Barbara 1993 - 1997

advisee of

  • graduate advising relationship

    • Schimmel, Paul, Ph.D.  candidacy, 2002 - 2006
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Contact

full name

  • Leslie Ann Nangle Greene

geographic location

  • Scripps California 

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