recent publications
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academic article
- Martinez, B. A., Rodrigues, P. R., Medina, R. M. N., Mondal, P., Harrison, N. J., Lone, M. A., Webster, A., Gurkar, A. U., Grill, B., Gill, M. S. An alternatively spliced, non-signaling insulin receptor modulates insulin sensitivity via insulin peptide sequestration in C. elegans Elife 2020 9 DOI:10.7554/eLife.49917 PMID:32096469 PMCID:PMC7041946
- Gurkar, A. U., Robinson, A. R., Cui, Y., Li, X., Allani, S. K., Webster, A., Muravia, M., Fallahi, M., Weissbach, H., Robbins, P. D., Wang, Y., Kelley, E. E., et al. Dysregulation of DAF-16/FOXO3A-mediated stress responses accelerates oxidative DNA damage induced aging Redox Biology 2018 18:191-199 DOI:10.1016/j.redox.2018.06.005 PMID:30031267 PMCID:PMC6076207
- Lucanic, M., Garrett, T., Gill, M. S., Lithgow, G. J. A simple method for high throughput chemical screening in Caenorhabditis elegans Journal of Visualized Experiments : JoVE 2018 DOI:10.3791/56892 PMID:29630057 PMCID:PMC5933220
- Khanna, A., Kumar, J., Vargas, M. A., Barrett, L., Katewa, S., Li, P., McCloskey, T., Sharma, A., Naude, N., Nelson, C., Brem, R., Killilea, D. W., et al. A genome-wide screen of bacterial mutants that enhance dauer formation in C. elegans Scientific Reports 2016 6 DOI:10.1038/srep38764 PMID:27958277 PMCID:PMC5153853
- Burd, C. E., Gill, M. S., Niedernhofer, L. J., Robbins, P. D., Austad, S. N., Barzilai, N., Kirkland, J. L. Barriers to the preclinical development of therapeutics that target aging mechanisms Journals of Gerontology Series A-Biological Sciences and Medical Sciences 2016 71:1388-1394 DOI:10.1093/gerona/glw112 PMID:27535964 PMCID:PMC5055650
- Lucanic, M., Garrett, T., Yu, I., Calahorro, F., Shahmirzadi, A. A., Miller, A., Gill, M. S., Hughes, R. E., Holden-Dye, L., Lithgow, G. J. Chemical activation of a food deprivation signal extends lifespan Aging Cell 2016 15:832-841 DOI:10.1111/acel.12492 PMID:27220516 PMCID:PMC5013014
- Rodrigues, P. R., Kaul, T. K., Ho, J. H., Lucanic, M., Burkewitz, K., Mair, W. B., Held, J. M., Bohn, L. M., Gill, M. S. Synthetic ligands of cannabinoid receptors affect dauer formation in the nematode Caenorhabditis elegans G3-Genes Genomes Genetics 2016 6:1695-1705 DOI:10.1534/g3.116.026997 PMID:27172180 PMCID:PMC4889665
- Harrison, N., Lone, M. A., Kaul, T. K., Rodrigues, P. R., Ogungbe, I. V., Gill, M. S. Characterization of N-acyl phosphatidylethanolamine-specific phospholipase-D isoforms in the nematode Caenorhabditis elegans PLoS One 2014 9:e113007 DOI:10.1371/journal.pone.0113007 PMID:25423491 PMCID:PMC4244089
- Clayton, P. E., Gill, M. S., Tillmann, V., Westwood, M. Translational neuroendocrinology: control of human growth Journal of Neuroendocrinology 2014 26:349-355 DOI:10.1111/jne.12156 PMID:24698533
- Kaul, T. K., Reis Rodrigues, P., Ogungbe, I. V., Kapahi, P., Gill, M. S. Bacterial fatty acids enhance recovery from the dauer larva in Caenorhabditis elegans PLoS One 2014 9:e86979 DOI:10.1371/journal.pone.0086979 PMID:24475206 PMCID:PMC3901721
- Sasaki, T., Lian, S., Qi, J., Bayliss, P. E., Carr, C. E., Johnson, J. L., Guha, S., Kobler, P., Catz, S. D., Gill, M., Jia, K., Klionsky, D. J., et al. Aberrant autolysosomal regulation is linked to the induction of embryonic senescence: differential roles of Beclin 1 and p53 in vertebrate Spns1 deficiency PLoS Genetics 2014 10:e1004409 DOI:10.1371/journal.pgen.1004409 PMID:24967584 PMCID:PMC4072523
- Katewa, S. D., Demontis, F., Kolipinski, M., Hubbard, A., Gill, M. S., Perrimon, N., Melov, S., Kapahi, P. Intramyocellular fatty-acid metabolism plays a critical role in mediating responses to dietary restriction in Drosophila melanogaster Cell Metabolism 2012 16:97-103 DOI:10.1016/j.cmet.2012.06.005 PMID:22768842 PMCID:PMC3400463
- Ripke, S., Sanders, A. R., Kendler, K. S., Levinson, D. F., Sklar, P., Holmans, P. A., Lin, D. Y., Duan, J., Ophoff, R. A., Andreassen, O. A., Scolnick, E., Cichon, S., et al. Genome-wide association study identifies five new schizophrenia loci Nature Genetics 2011 43:969-76 DOI:10.1038/ng.940 PMID:21926974 PMCID:PMC3303194
- Sklar, P., Ripke, S., Scott, L. J., Andreassen, O. A., Cichon, S., Craddock, N., Edenberg, H. J., Nurnberger, J. I., Rietschel, M., Blackwood, D., Corvin, A., Flickinger, M., et al. Large-scale genome-wide association analysis of bipolar disorder identifies a new susceptibility locus near odz4 Nature Genetics 2011 43:977-983 DOI:10.1038/ng.943 PMID:21926972 PMCID:PMC3637176
- Medeiros, L. A., Dennis, L. M., Gill, M. E., Houbaviy, H., Markoulaki, S., Fu, D. D., White, A. C., Kirak, O., Sharp, P. A., Page, D. C., Jaenisch, R. Mir-290-295 deficiency in mice results in partially penetrant embryonic lethality and germ cell defects Proceedings of the National Academy of Sciences of the United States of America 2011 108:14163-14168 DOI:10.1073/pnas.1111241108 PMID:21844366 PMCID:PMC3161528
- Lucanic, M., Held, J. M., Vantipalli, M. C., Klang, I. M., Graham, J. B., Gibson, B. W., Lithgow, G. J., Gill, M. S. N-acylethanolamine signalling mediates the effect of diet on lifespan in Caenorhabditis elegans Nature 2011 473:226-229 DOI:10.1038/nature10007 PMID:21562563 PMCID:PMC3093655
- Benedetti, M. G., Foster, A. L., Vantipalli, M. C., White, M. P., Sampayo, J. N., Gill, M. S., Olsen, A., Lithgow, G. J. Compounds that confer thermal stress resistance and extended lifespan Experimental Gerontology 2008 43:882-891 DOI:10.1016/j.exger.2008.08.049 PMID:18755260 PMCID:PMC2603168
- Held, J. M., White, M. P., Fisher, A. L., Gibson, B. W., Lithgow, G. J., Gill, M. S. DAF-12-dependent rescue of dauer formation in Caenorhabditis elegans by (25S)-cholestenoic acid Aging Cell 2006 5:283-291 DOI:10.1111/j.1474-9726.2006.00218.x PMID:16913876
- Gill, M. S. Endocrine targets for pharmacological intervention in aging in Caenorhabditis elegans Aging Cell 2006 5:23-30 DOI:10.1111/j.1474-9726.2006.00186.x PMID:16441840
- Lithgow, G. J., Gill, M. S., Olsen, A., Sampayo, J. N. Pharmacological intervention in invertebrate aging Age 2005 27:213-223 DOI:10.1007/s11357-005-3625-3 PMID:23598654 PMCID:PMC3458493
- Gill, M. S., Held, J. M., Fisher, A. L., Gibson, B. W., Lithgow, G. J. Lipophilic regulator of a developmental switch in Caenorhabditis elegans Aging Cell 2004 3:413-421 DOI:10.1111/j.1474-9728.2004.00126.x PMID:15569358
- Sampayo, J. N., Gill, M. S., Lithgow, G. J. Oxidative stress and aging - the use of superoxide dismutase/catalase mimetics to extend lifespan Biochemical Society Transactions 2003 31:1305-1307 PMID:14641049
- Gill, M. S., Olsen, A., Sampayo, J. N., Lithgow, G. J. An automated high-throughput assay for survival of the nematode Caenorhabditis elegans Free Radical Biology and Medicine 2003 35:558-565 DOI:10.1016/s0891-5849(03)00328-9 PMID:12957648
- Zaman, N., Hall, C. M., Gill, M. S., Jones, J., Tillmann, V., Westwood, M., Whatmore, A. J., Clayton, P. E. Leptin measurement in urine in children and its relationship to other growth peptides in serum and urine Clinical Endocrinology 2003 58:78-85 DOI:10.1046/j.1365-2265.2003.01677.x PMID:12519416
- Gleeson, H. K., Souza, A. H. O., Gill, M. S., Wieringa, G. E., Barretto, E. S. D., Barretto, J. A. S., Shalet, S. M., Aguiar-Oliveira, M. H., Clayton, P. E. Lipid profiles in untreated severe congenital isolated growth hormone deficiency through the lifespan Clinical Endocrinology 2002 57:89-95 DOI:10.1046/j.1365-2265.2002.01568.x PMID:12100075
- Patel, L., Cooper, C. D., Quinton, N. D., Butler, G. E., Gill, M. S., Jefferson, I. G., Kibirige, M. S., Price, D. A., Shalet, S. M., Wales, J. K. H., Ross, R. J. M., Clayton, P. E., et al. Serum leptin and leptin binding activity in children and adolescents with hypothalamic dysfunction Journal of Pediatric Endocrinology & Metabolism 2002 15:963-971 DOI:10.1515/JPEM.2002.15.7.963 PMID:12199340
- Barreto, J. A. S., Alcantara, M. R. S., Salvatori, R., Barreto, M. A., Sousa, A. C. S., Bastos, V., Souza, A. H., Pereira, R. M. C., Clayton, P. E., Gill, M. S., Aguiar-Oliveira, M. H. Familial isolated growth hormone deficiency is associated with increased systolic blood pressure, central obesity, and dyslipidemia Journal of Clinical Endocrinology & Metabolism 2002 87:2018-2023 DOI:10.1210/jc.87.5.2018 PMID:11994335
- Tillmann, V., Foster, P. J., Gill, M. S., Price, D. A., Clayton, P. E. Short-term growth in children with growth disorders Annals of Human Biology 2002 29:89-104 DOI:10.1080/03014460110075666 PMID:11822486
- Gill, M. S., Tillmann, V., Veldhuis, J. D., Clayton, P. E. Patterns of GH output and their synchrony with short-term height increments influence stature and growth performance in normal children Journal of Clinical Endocrinology & Metabolism 2001 86:5860-5863 DOI:10.1210/jc.86.12.5860 PMID:11739452
- McFerran, D. W., Stirland, J. A., Norris, A. J., Khan, R. A., Takasuka, N., Seymour, Z. C., Gill, M. S., Robertson, W. R., Loudon, A. S. I., Davis, J. R. E., White, M. R. H. Persistent synchronized oscillations in prolactin gene promoter activity in living pituitary cells Endocrinology 2001 142:3255-3260 DOI:10.1210/en.142.7.3255 PMID:11416049
- Melov, S., Ravenscroft, J., Malik, S., Gill, M. S., Walker, D. W., Clayton, P. E., Wallace, D. C., Malfroy, B., Doctrow, S. R., Lithgow, G. J. Extension of life-span with superoxide dismutase/catalase mimetics Science 2000 289:1567-1569 DOI:10.1126/science.289.5484.1567 PMID:10968795
- Tillmann, V., Patel, L., Gill, M. S., Whatmore, A. J., Price, D. A., Kibirige, M. S., Wales, J. K., Clayton, P. E. Monitoring serum insulin-like growth factor-I (IGF-I), IGF binding protein-3 (IGFBP-3), IGF-I/IGFBP-3 molar ratio and leptin during growth hormone treatment for disordered growth Clinical Endocrinology 2000 53:329-336 PMID:10971450
- Aguiar-Oliveira, M. H., Gill, M. S., Barretto, E. S. D., Alcantara, M. R. S., Miraki-Moud, F., Menezes, C. A., Souza, A. H. O., Martinelli, C. E., Pereira, F. A., Salvatori, R., Levine, M. A., Shalet, S. M., et al. Effect of severe growth hormone (GH) deficiency due to a mutation in the GH-releasing hormone receptor on insulin-like growth factors (IGFs), IGF-binding proteins, and ternary complex formation throughout life Journal of Clinical Endocrinology & Metabolism 1999 84:4118-4126 DOI:10.1210/jc.84.11.4118 PMID:10566659
- Barretto, E. S. D., Gill, M. S., de Freitas, M. E. S., Magalhaes, M. M. G., Souza, A. H. O., Aguiar-Oliveira, M. H., Clayton, P. E. Serum leptin and body composition in children with familial GH deficiency (GHD) due to a mutation in the growth hormone-releasing hormone (GHRH) receptor Clinical Endocrinology 1999 51:559-564 PMID:10594516
- Quinton, N. D., Smith, R. F., Clayton, P. E., Gill, M. S., Shalet, S., Justice, S. K., Simon, S. A., Walters, S., Postel-Vinay, M. C., Blakemore, A. I. F., Ross, R. J. M. Leptin binding activity changes with age: The link between leptin and puberty Journal of Clinical Endocrinology & Metabolism 1999 84:2336-2341 DOI:10.1210/jc.84.7.2336 PMID:10404799
- Gill, M. S., Hall, C. M., Tillmann, V., Clayton, P. E. Constitutional delay in growth and puberty (CDGP) is associated with hypoleptinaemia Clinical Endocrinology 1999 50:721-726 DOI:10.1046/j.1365-2265.1999.00736.x PMID:10468943
- Hall, C. M., Gill, M. S., Foster, P., Pennells, L., Tillmann, V., Jones, J., Price, D. A., Clayton, P. E. Relationship between serum and urinary insulin-like growth factor-I through childhood and adolescence: Their use in the assessment of disordered growth Clinical Endocrinology 1999 50:611-618 DOI:10.1046/j.1365-2265.1999.00699.x PMID:10468927
- Gill, M. S., Thalange, N. K. S., Foster, P. J., Tillmann, V., Price, D. A., Diggle, P. J., Clayton, P. E. Regular fluctuations in growth hormone (GH) release determine normal human growth Growth Hormone & IGF Research 1999 9:114-122 DOI:10.1054/ghir.1999.0095 PMID:10373344
- Gill, M. S., Toogood, A. A., Jones, J., Clayton, P. E., Shalet, S. M. Serum leptin response to the acute and chronic administration of growth hormone (GH) to elderly subjects with GH deficiency Journal of Clinical Endocrinology & Metabolism 1999 84:1288-1295 DOI:10.1210/jc.84.4.1288 PMID:10199769
- Tillmann, V., Thalange, N. K. S., Foster, P. J., Gill, M. S., Price, D. A., Clayton, P. E. The relationship between stature, growth, and short-term changes in height and weight in normal prepubertal children Pediatric Research 1998 44:882-886 DOI:10.1203/00006450-199812000-00010 PMID:9853922
- Tillmann, V., Shalet, S. M., Price, D. A., Wales, J. K. H., Pennells, L., Soden, J., Gill, M. S., Whatmore, A. J., Clayton, P. E. Serum insulin-like growth factor-I, IGF binding protein-3 and IGFBP-3 protease activity after cranial irradiation Hormone Research 1998 50:71-77 DOI:10.1159/000023237 PMID:9701699
- Gill, M. S., Toogood, A. A., O'Neill, P. A., Thorner, M. O., Shalet, S. M., Clayton, P. E. Urinary growth hormone (GH), insulin-like growth factor I (IGF-I), and IGF-binding protein-3 measurements in the diagnosis of adult GH deficiency Journal of Clinical Endocrinology & Metabolism 1998 83:2562-2565 DOI:10.1210/jc.83.7.2562 PMID:9661643
- Gill, M. S., Toogood, A. A., Oneill, P. A., Adams, J. E., Thorner, M. O., Shalet, S. M., Clayton, P. E. Relationship between growth hormone (GH) status, serum leptin and body composition in healthy and GH deficient elderly subjects Clinical Endocrinology 1997 47:161-167 DOI:10.1046/j.1365-2265.1997.2291056.x PMID:9302388
- Clayton, P. E., Gill, M. S., Hall, C. M., Tillmann, V., Whatmore, A. J., Price, D. A. Serum leptin through childhood and adolescence Clinical Endocrinology 1997 46:727-733 DOI:10.1046/j.1365-2265.1997.2081026.x PMID:9274704
- Gill, M. S., Whatmore, A. J., Tillman, V., White, A., Addison, G. M., Price, D. A., Clayton, P. E. Urinary IGF and IGF binding protein-3 in children with disordered growth. The North West Paediatric Endocrine Group Clinical Endocrinology 1997 46:483-492 DOI:10.1046/j.1365-2265.1997.1670981.x PMID:9196612
- Thalange, N. K. S., Foster, P. J., Gill, M. S., Price, D. A., Clayton, P. E. Model of normal prepubertal growth Archives of Disease in Childhood 1996 75:427-431 PMID:8957957 PMCID:PMC1511779
- Thalange, N. K. S., Gill, M. S., Gill, L., Whatmore, A. J., Addison, G. M., Price, D. A., Clayton, P. E. Infradian rhythms in urinary growth hormone excretion Journal of Clinical Endocrinology & Metabolism 1996 81:100-106 DOI:10.1210/jc.81.1.100 PMID:8550735