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Gill, Matt
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Gill, Matt

Faculty Member
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Positions

  • 2018 - Associate Professor, Molecular Medicine , Scripps Research
  • 2011 - Faculty Member, Skaggs Graduate School of Chemical and Biological Sciences , Scripps Research
  • Affiliate Research Assistant Professor, Center for Molecular Biology and Biotechnology , Florida Atlantic University
  • 2017 - 2018 Assistant Professor, Molecular Medicine , Scripps Research
  • 2011 - 2017 Assistant Professor, Metabolism and Aging , Scripps Research
  • 2007 - 2011 Assistant Research Professor, Buck Institute for Research on Aging
  • 2004 - 2007 Staff Scientist, Buck Institute for Research on Aging
  • 2002 - 2004 Brookdale National Fellow, Buck Institute for Research on Aging
  • 1998 - 2001 Medical Research Council Training Fellow, The University of Manchester

Contact

  • mgill@scripps.edu

Websites

  • Matt Gill, Ph.D.
  • Laboratory Website
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Publications

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  • academic article

    • Martinez, B. A., Rodrigues, P. R., Medina, R. M. N., Mondal, P., Harrison, N. J., Lone, M. A., Webster, A., Gurkar, A. U., Grill, B., Gill, M. S. An alternatively spliced, non-signaling insulin receptor modulates insulin sensitivity via insulin peptide sequestration in C. elegans Elife  2020 9  DOI:10.7554/eLife.49917  PMID:32096469  PMCID:PMC7041946
    • Gurkar, A. U., Robinson, A. R., Cui, Y., Li, X., Allani, S. K., Webster, A., Muravia, M., Fallahi, M., Weissbach, H., Robbins, P. D., Wang, Y., Kelley, E. E., et al. Dysregulation of DAF-16/FOXO3A-mediated stress responses accelerates oxidative DNA damage induced aging Redox Biology  2018 18:191-199  DOI:10.1016/j.redox.2018.06.005  PMID:30031267  PMCID:PMC6076207
    • Lucanic, M., Garrett, T., Gill, M. S., Lithgow, G. J. A simple method for high throughput chemical screening in Caenorhabditis elegans Journal of Visualized Experiments : JoVE  2018  DOI:10.3791/56892  PMID:29630057  PMCID:PMC5933220
    • Khanna, A., Kumar, J., Vargas, M. A., Barrett, L., Katewa, S., Li, P., McCloskey, T., Sharma, A., Naude, N., Nelson, C., Brem, R., Killilea, D. W., et al. A genome-wide screen of bacterial mutants that enhance dauer formation in C. elegans Scientific Reports  2016 6  DOI:10.1038/srep38764  PMID:27958277  PMCID:PMC5153853
    • Burd, C. E., Gill, M. S., Niedernhofer, L. J., Robbins, P. D., Austad, S. N., Barzilai, N., Kirkland, J. L. Barriers to the preclinical development of therapeutics that target aging mechanisms Journals of Gerontology Series A-Biological Sciences and Medical Sciences  2016 71:1388-1394  DOI:10.1093/gerona/glw112  PMID:27535964  PMCID:PMC5055650
    • Lucanic, M., Garrett, T., Yu, I., Calahorro, F., Shahmirzadi, A. A., Miller, A., Gill, M. S., Hughes, R. E., Holden-Dye, L., Lithgow, G. J. Chemical activation of a food deprivation signal extends lifespan Aging Cell  2016 15:832-841  DOI:10.1111/acel.12492  PMID:27220516  PMCID:PMC5013014
    • Rodrigues, P. R., Kaul, T. K., Ho, J. H., Lucanic, M., Burkewitz, K., Mair, W. B., Held, J. M., Bohn, L. M., Gill, M. S. Synthetic ligands of cannabinoid receptors affect dauer formation in the nematode Caenorhabditis elegans G3-Genes Genomes Genetics  2016 6:1695-1705  DOI:10.1534/g3.116.026997  PMID:27172180  PMCID:PMC4889665
    • Harrison, N., Lone, M. A., Kaul, T. K., Rodrigues, P. R., Ogungbe, I. V., Gill, M. S. Characterization of N-acyl phosphatidylethanolamine-specific phospholipase-D isoforms in the nematode Caenorhabditis elegans PLoS One  2014 9:e113007  DOI:10.1371/journal.pone.0113007  PMID:25423491  PMCID:PMC4244089
    • Clayton, P. E., Gill, M. S., Tillmann, V., Westwood, M. Translational neuroendocrinology: control of human growth Journal of Neuroendocrinology  2014 26:349-355  DOI:10.1111/jne.12156  PMID:24698533
    • Kaul, T. K., Reis Rodrigues, P., Ogungbe, I. V., Kapahi, P., Gill, M. S. Bacterial fatty acids enhance recovery from the dauer larva in Caenorhabditis elegans PLoS One  2014 9:e86979  DOI:10.1371/journal.pone.0086979  PMID:24475206  PMCID:PMC3901721
    • Sasaki, T., Lian, S., Qi, J., Bayliss, P. E., Carr, C. E., Johnson, J. L., Guha, S., Kobler, P., Catz, S. D., Gill, M., Jia, K., Klionsky, D. J., et al. Aberrant autolysosomal regulation is linked to the induction of embryonic senescence: differential roles of Beclin 1 and p53 in vertebrate Spns1 deficiency PLoS Genetics  2014 10:e1004409  DOI:10.1371/journal.pgen.1004409  PMID:24967584  PMCID:PMC4072523
    • Katewa, S. D., Demontis, F., Kolipinski, M., Hubbard, A., Gill, M. S., Perrimon, N., Melov, S., Kapahi, P. Intramyocellular fatty-acid metabolism plays a critical role in mediating responses to dietary restriction in Drosophila melanogaster Cell Metabolism  2012 16:97-103  DOI:10.1016/j.cmet.2012.06.005  PMID:22768842  PMCID:PMC3400463
    • Ripke, S., Sanders, A. R., Kendler, K. S., Levinson, D. F., Sklar, P., Holmans, P. A., Lin, D. Y., Duan, J., Ophoff, R. A., Andreassen, O. A., Scolnick, E., Cichon, S., et al. Genome-wide association study identifies five new schizophrenia loci Nature Genetics  2011 43:969-76  DOI:10.1038/ng.940  PMID:21926974  PMCID:PMC3303194
    • Sklar, P., Ripke, S., Scott, L. J., Andreassen, O. A., Cichon, S., Craddock, N., Edenberg, H. J., Nurnberger, J. I., Rietschel, M., Blackwood, D., Corvin, A., Flickinger, M., et al. Large-scale genome-wide association analysis of bipolar disorder identifies a new susceptibility locus near odz4 Nature Genetics  2011 43:977-983  DOI:10.1038/ng.943  PMID:21926972  PMCID:PMC3637176
    • Medeiros, L. A., Dennis, L. M., Gill, M. E., Houbaviy, H., Markoulaki, S., Fu, D. D., White, A. C., Kirak, O., Sharp, P. A., Page, D. C., Jaenisch, R. Mir-290-295 deficiency in mice results in partially penetrant embryonic lethality and germ cell defects Proceedings of the National Academy of Sciences of the United States of America  2011 108:14163-14168  DOI:10.1073/pnas.1111241108  PMID:21844366  PMCID:PMC3161528
    • Lucanic, M., Held, J. M., Vantipalli, M. C., Klang, I. M., Graham, J. B., Gibson, B. W., Lithgow, G. J., Gill, M. S. N-acylethanolamine signalling mediates the effect of diet on lifespan in Caenorhabditis elegans Nature  2011 473:226-229  DOI:10.1038/nature10007  PMID:21562563  PMCID:PMC3093655
    • Benedetti, M. G., Foster, A. L., Vantipalli, M. C., White, M. P., Sampayo, J. N., Gill, M. S., Olsen, A., Lithgow, G. J. Compounds that confer thermal stress resistance and extended lifespan Experimental Gerontology  2008 43:882-891  DOI:10.1016/j.exger.2008.08.049  PMID:18755260  PMCID:PMC2603168
    • Held, J. M., White, M. P., Fisher, A. L., Gibson, B. W., Lithgow, G. J., Gill, M. S. DAF-12-dependent rescue of dauer formation in Caenorhabditis elegans by (25S)-cholestenoic acid Aging Cell  2006 5:283-291  DOI:10.1111/j.1474-9726.2006.00218.x  PMID:16913876
    • Gill, M. S. Endocrine targets for pharmacological intervention in aging in Caenorhabditis elegans Aging Cell  2006 5:23-30  DOI:10.1111/j.1474-9726.2006.00186.x  PMID:16441840
    • Lithgow, G. J., Gill, M. S., Olsen, A., Sampayo, J. N. Pharmacological intervention in invertebrate aging Age  2005 27:213-223  DOI:10.1007/s11357-005-3625-3  PMID:23598654  PMCID:PMC3458493
    • Gill, M. S., Held, J. M., Fisher, A. L., Gibson, B. W., Lithgow, G. J. Lipophilic regulator of a developmental switch in Caenorhabditis elegans Aging Cell  2004 3:413-421  DOI:10.1111/j.1474-9728.2004.00126.x  PMID:15569358
    • Sampayo, J. N., Gill, M. S., Lithgow, G. J. Oxidative stress and aging - the use of superoxide dismutase/catalase mimetics to extend lifespan Biochemical Society Transactions  2003 31:1305-1307  PMID:14641049
    • Gill, M. S., Olsen, A., Sampayo, J. N., Lithgow, G. J. An automated high-throughput assay for survival of the nematode Caenorhabditis elegans Free Radical Biology and Medicine  2003 35:558-565  DOI:10.1016/s0891-5849(03)00328-9  PMID:12957648
    • Zaman, N., Hall, C. M., Gill, M. S., Jones, J., Tillmann, V., Westwood, M., Whatmore, A. J., Clayton, P. E. Leptin measurement in urine in children and its relationship to other growth peptides in serum and urine Clinical Endocrinology  2003 58:78-85  DOI:10.1046/j.1365-2265.2003.01677.x  PMID:12519416
    • Gleeson, H. K., Souza, A. H. O., Gill, M. S., Wieringa, G. E., Barretto, E. S. D., Barretto, J. A. S., Shalet, S. M., Aguiar-Oliveira, M. H., Clayton, P. E. Lipid profiles in untreated severe congenital isolated growth hormone deficiency through the lifespan Clinical Endocrinology  2002 57:89-95  DOI:10.1046/j.1365-2265.2002.01568.x  PMID:12100075
    • Patel, L., Cooper, C. D., Quinton, N. D., Butler, G. E., Gill, M. S., Jefferson, I. G., Kibirige, M. S., Price, D. A., Shalet, S. M., Wales, J. K. H., Ross, R. J. M., Clayton, P. E., et al. Serum leptin and leptin binding activity in children and adolescents with hypothalamic dysfunction Journal of Pediatric Endocrinology & Metabolism  2002 15:963-971  DOI:10.1515/JPEM.2002.15.7.963  PMID:12199340
    • Barreto, J. A. S., Alcantara, M. R. S., Salvatori, R., Barreto, M. A., Sousa, A. C. S., Bastos, V., Souza, A. H., Pereira, R. M. C., Clayton, P. E., Gill, M. S., Aguiar-Oliveira, M. H. Familial isolated growth hormone deficiency is associated with increased systolic blood pressure, central obesity, and dyslipidemia Journal of Clinical Endocrinology & Metabolism  2002 87:2018-2023  DOI:10.1210/jc.87.5.2018  PMID:11994335
    • Tillmann, V., Foster, P. J., Gill, M. S., Price, D. A., Clayton, P. E. Short-term growth in children with growth disorders Annals of Human Biology  2002 29:89-104  DOI:10.1080/03014460110075666  PMID:11822486
    • Gill, M. S., Tillmann, V., Veldhuis, J. D., Clayton, P. E. Patterns of GH output and their synchrony with short-term height increments influence stature and growth performance in normal children Journal of Clinical Endocrinology & Metabolism  2001 86:5860-5863  DOI:10.1210/jc.86.12.5860  PMID:11739452
    • McFerran, D. W., Stirland, J. A., Norris, A. J., Khan, R. A., Takasuka, N., Seymour, Z. C., Gill, M. S., Robertson, W. R., Loudon, A. S. I., Davis, J. R. E., White, M. R. H. Persistent synchronized oscillations in prolactin gene promoter activity in living pituitary cells Endocrinology  2001 142:3255-3260  DOI:10.1210/en.142.7.3255  PMID:11416049
    • Melov, S., Ravenscroft, J., Malik, S., Gill, M. S., Walker, D. W., Clayton, P. E., Wallace, D. C., Malfroy, B., Doctrow, S. R., Lithgow, G. J. Extension of life-span with superoxide dismutase/catalase mimetics Science  2000 289:1567-1569  DOI:10.1126/science.289.5484.1567  PMID:10968795
    • Tillmann, V., Patel, L., Gill, M. S., Whatmore, A. J., Price, D. A., Kibirige, M. S., Wales, J. K., Clayton, P. E. Monitoring serum insulin-like growth factor-I (IGF-I), IGF binding protein-3 (IGFBP-3), IGF-I/IGFBP-3 molar ratio and leptin during growth hormone treatment for disordered growth Clinical Endocrinology  2000 53:329-336  PMID:10971450
    • Aguiar-Oliveira, M. H., Gill, M. S., Barretto, E. S. D., Alcantara, M. R. S., Miraki-Moud, F., Menezes, C. A., Souza, A. H. O., Martinelli, C. E., Pereira, F. A., Salvatori, R., Levine, M. A., Shalet, S. M., et al. Effect of severe growth hormone (GH) deficiency due to a mutation in the GH-releasing hormone receptor on insulin-like growth factors (IGFs), IGF-binding proteins, and ternary complex formation throughout life Journal of Clinical Endocrinology & Metabolism  1999 84:4118-4126  DOI:10.1210/jc.84.11.4118  PMID:10566659
    • Barretto, E. S. D., Gill, M. S., de Freitas, M. E. S., Magalhaes, M. M. G., Souza, A. H. O., Aguiar-Oliveira, M. H., Clayton, P. E. Serum leptin and body composition in children with familial GH deficiency (GHD) due to a mutation in the growth hormone-releasing hormone (GHRH) receptor Clinical Endocrinology  1999 51:559-564  PMID:10594516
    • Quinton, N. D., Smith, R. F., Clayton, P. E., Gill, M. S., Shalet, S., Justice, S. K., Simon, S. A., Walters, S., Postel-Vinay, M. C., Blakemore, A. I. F., Ross, R. J. M. Leptin binding activity changes with age: The link between leptin and puberty Journal of Clinical Endocrinology & Metabolism  1999 84:2336-2341  DOI:10.1210/jc.84.7.2336  PMID:10404799
    • Gill, M. S., Hall, C. M., Tillmann, V., Clayton, P. E. Constitutional delay in growth and puberty (CDGP) is associated with hypoleptinaemia Clinical Endocrinology  1999 50:721-726  DOI:10.1046/j.1365-2265.1999.00736.x  PMID:10468943
    • Hall, C. M., Gill, M. S., Foster, P., Pennells, L., Tillmann, V., Jones, J., Price, D. A., Clayton, P. E. Relationship between serum and urinary insulin-like growth factor-I through childhood and adolescence: Their use in the assessment of disordered growth Clinical Endocrinology  1999 50:611-618  DOI:10.1046/j.1365-2265.1999.00699.x  PMID:10468927
    • Gill, M. S., Thalange, N. K. S., Foster, P. J., Tillmann, V., Price, D. A., Diggle, P. J., Clayton, P. E. Regular fluctuations in growth hormone (GH) release determine normal human growth Growth Hormone & IGF Research  1999 9:114-122  DOI:10.1054/ghir.1999.0095  PMID:10373344
    • Gill, M. S., Toogood, A. A., Jones, J., Clayton, P. E., Shalet, S. M. Serum leptin response to the acute and chronic administration of growth hormone (GH) to elderly subjects with GH deficiency Journal of Clinical Endocrinology & Metabolism  1999 84:1288-1295  DOI:10.1210/jc.84.4.1288  PMID:10199769
    • Tillmann, V., Thalange, N. K. S., Foster, P. J., Gill, M. S., Price, D. A., Clayton, P. E. The relationship between stature, growth, and short-term changes in height and weight in normal prepubertal children Pediatric Research  1998 44:882-886  DOI:10.1203/00006450-199812000-00010  PMID:9853922
    • Tillmann, V., Shalet, S. M., Price, D. A., Wales, J. K. H., Pennells, L., Soden, J., Gill, M. S., Whatmore, A. J., Clayton, P. E. Serum insulin-like growth factor-I, IGF binding protein-3 and IGFBP-3 protease activity after cranial irradiation Hormone Research  1998 50:71-77  DOI:10.1159/000023237  PMID:9701699
    • Gill, M. S., Toogood, A. A., O'Neill, P. A., Thorner, M. O., Shalet, S. M., Clayton, P. E. Urinary growth hormone (GH), insulin-like growth factor I (IGF-I), and IGF-binding protein-3 measurements in the diagnosis of adult GH deficiency Journal of Clinical Endocrinology & Metabolism  1998 83:2562-2565  DOI:10.1210/jc.83.7.2562  PMID:9661643
    • Gill, M. S., Toogood, A. A., Oneill, P. A., Adams, J. E., Thorner, M. O., Shalet, S. M., Clayton, P. E. Relationship between growth hormone (GH) status, serum leptin and body composition in healthy and GH deficient elderly subjects Clinical Endocrinology  1997 47:161-167  DOI:10.1046/j.1365-2265.1997.2291056.x  PMID:9302388
    • Clayton, P. E., Gill, M. S., Hall, C. M., Tillmann, V., Whatmore, A. J., Price, D. A. Serum leptin through childhood and adolescence Clinical Endocrinology  1997 46:727-733  DOI:10.1046/j.1365-2265.1997.2081026.x  PMID:9274704
    • Gill, M. S., Whatmore, A. J., Tillman, V., White, A., Addison, G. M., Price, D. A., Clayton, P. E. Urinary IGF and IGF binding protein-3 in children with disordered growth. The North West Paediatric Endocrine Group Clinical Endocrinology  1997 46:483-492  DOI:10.1046/j.1365-2265.1997.1670981.x  PMID:9196612
    • Thalange, N. K. S., Foster, P. J., Gill, M. S., Price, D. A., Clayton, P. E. Model of normal prepubertal growth Archives of Disease in Childhood  1996 75:427-431  PMID:8957957  PMCID:PMC1511779
    • Thalange, N. K. S., Gill, M. S., Gill, L., Whatmore, A. J., Addison, G. M., Price, D. A., Clayton, P. E. Infradian rhythms in urinary growth hormone excretion Journal of Clinical Endocrinology & Metabolism  1996 81:100-106  DOI:10.1210/jc.81.1.100  PMID:8550735

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  • Scripps Research Appoints Innovative Biochemist to Florida Faculty  Newsletter
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Research

research overview

  • Aging is the single most important factor determining the onset of human disease in developed countries.  With current demographic trends indicating that the number of individuals over the age of 65 in the US will rise from 35 million in the year 2000 (13% of the total population) to 70 million in the year 2030 (1 in 20) it is clear that an understanding of the processes that underpin aging and age-related disease represents a key challenge in the biomedical sciences.  

    In recent years there have been huge advances in our understanding of the aging process and many of these have stemmed from genetic analysis of the nematode Caenorhabditis elegans (C. elegans). These studies have identified endocrine signaling pathways conserved between worms and mammals that include receptors whose endogenous ligands are small, lipid-derived hormones that cannot be identified by genetic approaches alone.  These hormone pathways are also tractable drug targets and thus the identification of small molecule regulators of their activity could lead to rational drug development for aging and age-related disease.  Given the conservation of aging pathways between species, this approach is likely to open up new therapeutic avenues for combating human aging and age-related disease. 

    My lab uses an interdisciplinary approach that combines chemical screens, analytical chemistry, biochemistry and genetics to identify small molecule regulators of aging in C. elegans and determine their molecular mechanism of action.  Using this approach we have recently identified a group of lipid signaling molecules called N-acylethanolamines (NAEs) in the worm, one of which shows similarity to mammalian endocannabinoids and affects nematode lifespan by modulating pathways involved in nutrient sensing and dietary restriction.  Endocannabinoid pathways in mammals are well known to be involved in nutrient sensing and energy balance but a role in the aging process has not yet been demonstrated.  The discovery of NAEs and endocannabinoids in C. elegans not only provides a means of further investigating the role of these important signaling molecules in lifespan determination but also brings a powerful genetic system to the study of NAE physiology.

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Teaching

advisees

  • graduate advising relationship

    • Wong, Jensen, Ph.D.  candidate, 2017 -
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Background

education and training

  • Ph.D. in Endocrinology, The University of Manchester 1997
  • B.Sc. in Biochemistry, Newcastle University 1993
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Contact

full name

  • Matt S. Gill

geographic location

  • Scripps California 

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