recent publications
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academic article
- Rueedi, R., Ledda, M., Nicholls, A. W., Salek, R. M., Marques-Vidal, P., Morya, E., Sameshima, K., Montoliu, I., Da Silva, L., Collino, S., Martin, F. P., Rezzi, S., et al. Genome-wide association study of metabolic traits reveals novel gene-metabolite-disease links PLoS Genetics 2014 10 DOI:10.1371/journal.pgen.1004132 PMID:24586186 PMCID:PMC3930510
- Ledda, M., Kutalik, Z., Destito, M. C. S., Souza, M. M., Cirillo, C. A., Zamboni, A., Martin, N., Morya, E., Sameshima, K., Beckmann, J. S., le Coutre, J., Bergmann, S., et al. GWAS of human bitter taste perception identifies new loci and reveals additional complexity of bitter taste genetics Human Molecular Genetics 2014 23:259-267 DOI:10.1093/hmg/ddt404 PMID:23966204 PMCID:PMC3857948
- Montoliu, I., Genick, U., Ledda, M., Collino, S., Martin, F. P., le Coutre, J., Rezzi, S. Current status on genome-metabolome-wide associations: an opportunity in nutrition research Genes and Nutrition 2013 8:19-27 DOI:10.1007/s12263-012-0313-7 PMID:23065485 PMCID:PMC3534994
- Genick, U. K., Kutalik, Z., Ledda, M., Destito, M. C. S., Souza, M. M., Cirillo, C. A., Godinot, N., Martin, N., Morya, E., Sameshima, K., Bergmann, S., le Coutre, J. Sensitivity of genome-wide-association signals to phenotyping strategy: the PROP-TAS2R38 taste association as a benchmark PLoS One 2011 6 DOI:10.1371/journal.pone.0027745 PMID:22132133 PMCID:PMC3223210
- Montoliu, I., Martin, F. P., Guy, P. A., Tavazzi, I., Bruce, S., Collino, S., Galindo-Cuspinera, V., Genick, U., Martin, N., Le Coutre, J., Kochhar, S., Rezzi, S. Validation on high variance metabolic profiles: Taste stratification in a free living population Chemometrics and Intelligent Laboratory Systems 2010 104:8-19 DOI:10.1016/j.chemolab.2010.02.002
- Coureux, P. D., Fan, Z. P., Stojanoff, V., Genick, U. K. Picometer-scale conformational heterogeneity separates functional from nonfunctional states of a photoreceptor protein Structure 2008 16:863-872 DOI:10.1016/j.str.2008.02.022 PMID:18547519
- Genick, U. K. Structure-factor extrapolation using the scalar approximation: theory, applications and limitations Acta Crystallographica Section D-Biological Crystallography 2007 63:1029-1041 DOI:10.1107/s0907444907038164 PMID:17881820
- Coureux, P. D., Genick, U. K. Triggering and monitoring light-sensing reactions in protein crystals Methods in Enzymology 2007 422:305-337 DOI:10.1016/s0076-6879(06)22015-9 PMID:17628146
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Getzoff, E. D., Gutwin, K. N., Genick, U. K.
Anticipatory active-site motions and chromophore distortion prime photoreceptor PYP for light activation
Nature Structural Biology
2003
10:663-668
DOI:10.1038/nsb958
PMID:12872160
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Brudler, R., Meyer, T. E., Genick, U. K., Devanathan, S., Woo, T. T., Millar, D. P., Gerwert, K., Cusanovich, M. A., Tollin, G., Getzoff, E. D.
Coupling of hydrogen bonding to chromophore conformation and function in photoactive yellow protein
Biochemistry
2000
39:13478-13486
DOI:10.1021/bi0009946
PMID:11063584
- Genick, U. K., Chory, J. Red light sensing in plants Current Biology 2000 10:R651-R654 DOI:10.1016/s0960-9822(00)00694-1
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Demchuk, E., Genick, U. K., Woo, T. T., Getzoff, E. D., Bashford, D.
Protonation states and pH titration in the photocycle of photoactive yellow protein
Biochemistry
2000
39:1100-1113
DOI:10.1021/bi991513p
PMID:10653656
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Devanathan, S., Genick, U. K., Canestrelli, I. L., Meyer, T. E., Cusanovich, M. A., Getzoff, E. D., Tollin, G.
New insights into the photocycle of Ectothiorhodospira halophila photoactive yellow protein: Photorecovery of the long-lived photobleached intermediate in the Met100Ala mutant
Biochemistry
1998
37:11563-11568
DOI:10.1021/bi9803776
PMID:9708992
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Genick, U. K., Soltis, S. M., Kuhn, P., Canestrelli, I. L., Getzoff, E. D.
Structure at 0.85 Å resolution of an early protein photocycle intermediate
Nature
1998
392:206-209
PMID:9515969
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Devanathan, S., Genick, U. K., Getzoff, E. D., Meyer, T. E., Cusanovich, M. A., Tollin, G.
Preparation and properties of a 3,4-dihydroxycinnamic acid chromophore variant of the photoactive yellow protein
Archives of Biochemistry and Biophysics
1997
340:83-89
DOI:10.1006/abbi.1997.9902
PMID:9126280
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Genick, U. K., Borgstahl, G. E. O., Ng, K., Ren, Z., Pradervand, C., Burke, P. M., Srajer, V., Teng, T. Y., Schildkamp, W., McRee, D. E., Moffat, K., Getzoff, E. D.
Structure of a protein photocycle intermediate by millisecond time-resolved crystallography
Science
1997
275:1471-1475
DOI:10.1126/science.275.5305.1471
PMID:9045611
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Genick, U. K., Devanathan, S., Meyer, T. E., Canestrelli, I. L., Williams, E., Cusanovich, M. A., Tollin, G., Getzoff, E. D.
Active site mutants implicate key residues for control of color and light cycle kinetics of photoactive yellow protein
Biochemistry
1997
36:8-14
DOI:10.1021/bi9622884
PMID:8993312