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Genick, Ulrich
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Genick, Ulrich

Senior Scientist / Lecturer
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Positions

  • 2014 - Senior Scientist / Lecturer, Swiss Federal Institute of Technology Zurich (ETH)
  • 2014 Visiting Scientist, Swiss Federal Institute of Technology Zurich (ETH)
  • 2007 - 2013 Senior Research Scientist, Nestle
  • 2001 - 2007 Assistant Professor of Biochemistry, Brandeis University
  • 1999 - 2001 Postdoctoral Research Fellow, Salk Institute for Biological Studies
  • 1999 - 2001 Consultant for the design of the SIBYLS beamline, Lawrence Berkeley National Laboratory
Life science researcher with broad experience in cross-disciplinary research (genomics, biophysics, structural biology and biochemistry) in both academic and corporate settings.

Strong interest in teaching with focus on techniques that promote active learning and student engagement.

Experience organizing large-scale, multi-institution, cross-disciplinary research projects and research teams.

Founding member of the MIDATA.coop health data cooperative that allows individuals to manage and use their personal health and lifestyle data for their personal benefit and for the benefit of society at large. 

Promotes public awareness and self-empowerment in the area of personal genomics through public speaking and by organising citizen science projects.

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Publications

recent publications
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  • Publications without PubMed PMIDs

  • academic article

    • Rueedi, R., Ledda, M., Nicholls, A. W., Salek, R. M., Marques-Vidal, P., Morya, E., Sameshima, K., Montoliu, I., Da Silva, L., Collino, S., Martin, F. P., Rezzi, S., et al. Genome-wide association study of metabolic traits reveals novel gene-metabolite-disease links PLoS Genetics  2014 10  DOI:10.1371/journal.pgen.1004132  PMID:24586186  PMCID:PMC3930510
    • Ledda, M., Kutalik, Z., Destito, M. C. S., Souza, M. M., Cirillo, C. A., Zamboni, A., Martin, N., Morya, E., Sameshima, K., Beckmann, J. S., le Coutre, J., Bergmann, S., et al. GWAS of human bitter taste perception identifies new loci and reveals additional complexity of bitter taste genetics Human Molecular Genetics  2014 23:259-267  DOI:10.1093/hmg/ddt404  PMID:23966204  PMCID:PMC3857948
    • Montoliu, I., Genick, U., Ledda, M., Collino, S., Martin, F. P., le Coutre, J., Rezzi, S. Current status on genome-metabolome-wide associations: an opportunity in nutrition research Genes and Nutrition  2013 8:19-27  DOI:10.1007/s12263-012-0313-7  PMID:23065485  PMCID:PMC3534994
    • Genick, U. K., Kutalik, Z., Ledda, M., Destito, M. C. S., Souza, M. M., Cirillo, C. A., Godinot, N., Martin, N., Morya, E., Sameshima, K., Bergmann, S., le Coutre, J. Sensitivity of genome-wide-association signals to phenotyping strategy: the PROP-TAS2R38 taste association as a benchmark PLoS One  2011 6  DOI:10.1371/journal.pone.0027745  PMID:22132133  PMCID:PMC3223210
    • Montoliu, I., Martin, F. P., Guy, P. A., Tavazzi, I., Bruce, S., Collino, S., Galindo-Cuspinera, V., Genick, U., Martin, N., Le Coutre, J., Kochhar, S., Rezzi, S. Validation on high variance metabolic profiles: Taste stratification in a free living population Chemometrics and Intelligent Laboratory Systems  2010 104:8-19  DOI:10.1016/j.chemolab.2010.02.002
    • Coureux, P. D., Fan, Z. P., Stojanoff, V., Genick, U. K. Picometer-scale conformational heterogeneity separates functional from nonfunctional states of a photoreceptor protein Structure  2008 16:863-872  DOI:10.1016/j.str.2008.02.022  PMID:18547519
    • Genick, U. K. Structure-factor extrapolation using the scalar approximation: theory, applications and limitations Acta Crystallographica Section D-Biological Crystallography  2007 63:1029-1041  DOI:10.1107/s0907444907038164  PMID:17881820
    • Coureux, P. D., Genick, U. K. Triggering and monitoring light-sensing reactions in protein crystals Methods in Enzymology  2007 422:305-337  DOI:10.1016/s0076-6879(06)22015-9  PMID:17628146
    • degree-related publication Getzoff, E. D., Gutwin, K. N., Genick, U. K. Anticipatory active-site motions and chromophore distortion prime photoreceptor PYP for light activation Nature Structural Biology  2003 10:663-668  DOI:10.1038/nsb958  PMID:12872160
    • degree-related publication Brudler, R., Meyer, T. E., Genick, U. K., Devanathan, S., Woo, T. T., Millar, D. P., Gerwert, K., Cusanovich, M. A., Tollin, G., Getzoff, E. D. Coupling of hydrogen bonding to chromophore conformation and function in photoactive yellow protein Biochemistry  2000 39:13478-13486  DOI:10.1021/bi0009946  PMID:11063584
    • Genick, U. K., Chory, J. Red light sensing in plants Current Biology  2000 10:R651-R654  DOI:10.1016/s0960-9822(00)00694-1
    • degree-related publication Demchuk, E., Genick, U. K., Woo, T. T., Getzoff, E. D., Bashford, D. Protonation states and pH titration in the photocycle of photoactive yellow protein Biochemistry  2000 39:1100-1113  DOI:10.1021/bi991513p  PMID:10653656
    • degree-related publication Devanathan, S., Genick, U. K., Canestrelli, I. L., Meyer, T. E., Cusanovich, M. A., Getzoff, E. D., Tollin, G. New insights into the photocycle of Ectothiorhodospira halophila photoactive yellow protein: Photorecovery of the long-lived photobleached intermediate in the Met100Ala mutant Biochemistry  1998 37:11563-11568  DOI:10.1021/bi9803776  PMID:9708992
    • degree-related publication Genick, U. K., Soltis, S. M., Kuhn, P., Canestrelli, I. L., Getzoff, E. D. Structure at 0.85 Å resolution of an early protein photocycle intermediate Nature  1998 392:206-209  PMID:9515969
    • degree-related publication Devanathan, S., Genick, U. K., Getzoff, E. D., Meyer, T. E., Cusanovich, M. A., Tollin, G. Preparation and properties of a 3,4-dihydroxycinnamic acid chromophore variant of the photoactive yellow protein Archives of Biochemistry and Biophysics  1997 340:83-89  DOI:10.1006/abbi.1997.9902  PMID:9126280
    • degree-related publication Genick, U. K., Borgstahl, G. E. O., Ng, K., Ren, Z., Pradervand, C., Burke, P. M., Srajer, V., Teng, T. Y., Schildkamp, W., McRee, D. E., Moffat, K., Getzoff, E. D. Structure of a protein photocycle intermediate by millisecond time-resolved crystallography Science  1997 275:1471-1475  DOI:10.1126/science.275.5305.1471  PMID:9045611
    • degree-related publication Genick, U. K., Devanathan, S., Meyer, T. E., Canestrelli, I. L., Williams, E., Cusanovich, M. A., Tollin, G., Getzoff, E. D. Active site mutants implicate key residues for control of color and light cycle kinetics of photoactive yellow protein Biochemistry  1997 36:8-14  DOI:10.1021/bi9622884  PMID:8993312
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Background

education and training

  • Ph.D. in Macromolecular and Cellular Structure and Chemistry, Scripps Research 1993 - 1999
  • Diploma in Biochemistry, Free University of Berlin 1988 - 1994

advisee of

  • graduate advising relationship

    • Getzoff, Elizabeth, Ph.D.  candidacy, 1994 - 1999
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Contact

full name

  • Ulrich Karl Genick

geographic location

  • Scripps California 

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