recent publications
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academic article
- Prasad, M., Wojciech, L., Brzostek, J., Hu, J. F., Chua, Y. L., Tung, D. W. H., Yap, J., Rybakin, V., Gascoigne, N. R. J. Expansion of an Unusual Virtual Memory CD8(+) Subpopulation Bearing V alpha 3.2 TCR in Themis-Deficient Mice Frontiers in Immunology 2021 12 DOI:10.3389/fimmu.2021.644483 PMID:33897691 PMCID:PMC8058184
- Paster, W., Bruger, A. M., Katsch, K., Gregoire, C., Roncagalli, R., Fu, G., Gascoigne, N. R. J., Nika, K., Cohnen, A., Feller, S. M., Simister, P. C., Molder, K. C., et al. A THEMIS:SHP1 complex promotes T-cell survival EMBO Journal 2015 34:393-409 DOI:10.15252/embj.201387725 PMID:25535246 PMCID:PMC4339124
- Rybakin, V., Westernberg, L., Fu, G., Kim, H. O., Ampudia, J., Sauer, K., Gascoigne, N. R. J. Allelic exclusion of TCR α-chains upon severe restriction of Vα repertoire PLoS One 2014 9 DOI:10.1371/journal.pone.0114320 PMID:25500569 PMCID:PMC4264757
- Fu, G., Rybakin, V., Brzostek, J., Paster, W., Acuto, O., Gascoigne, N. R. J. Fine-tuning T cell receptor signaling to control T cell development Trends in Immunology 2014 35:311-318 DOI:10.1016/j.it.2014.05.003 PMID:24951034 PMCID:PMC4119814
- Kong, K. F., Fu, G., Zhang, Y., Yokosuka, T., Casas, J., Canonigo-Balancio, A. J., Becart, S., Kim, G., Yates III, J. R., Kronenberg, M., Saito, T., Gascoigne, N. R. J., et al. Protein kinase C-eta controls CTLA-4-mediated regulatory T cell function Nature Immunology 2014 15:465-472 DOI:10.1038/ni.2866 PMID:24705298 PMCID:PMC4040250
- Nabekura, T., Kanaya, M., Shibuya, A., Fu, G., Gascoigne, N. R. J., Lanier, L. L. Costimulatory molecule DNAM-1 is essential for optimal differentiation of memory natural killer cells during mouse cytomegalovirus infection Immunity 2014 40:225-234 DOI:10.1016/j.immuni.2013.12.011 PMID:24440149 PMCID:PMC3943894
- Casas, J., Brzostek, J., Zarnitsyna, V. I., Hong, J. S., Wei, Q., Hoerter, J. A. H., Fu, G., Ampudia, J., Zamoyska, R., Zhu, C., Gascoigne, N. R. J. Ligand-engaged TCR is triggered by Lck not associated with CD8 coreceptor Nature Communications 2014 5:5624 DOI:10.1038/ncomms6624 PMID:25427562 PMCID:PMC4248239
- Fu, G., Casas, J., Rigaud, S., Rybakin, V., Lambolez, F., Brzostek, J., Hoerter, J. A. H., Paster, W., Acuto, O., Cheroutre, H., Sauer, K., Gascoigne, N. R. J. Themis sets the signal threshold for positive and negative selection in T-cell development Nature 2013 504:441-445 DOI:10.1038/nature12718 PMID:24226767 PMCID:PMC3977001
- Mukherjee, S., Rigaud, S., Seok, S. C., Fu, G., Prochenka, A., Dworkin, M., Gascoigne, N. R. J., Vieland, V. J., Sauer, K., Das, J. In silico modeling of Itk activation kinetics in thymocytes suggests competing positive and negative IP4 mediated feedbacks increase robustness PLoS One 2013 8:e73937 DOI:10.1371/journal.pone.0073937 PMID:24066087 PMCID:PMC3774804
- Hoerter, J. A. H., Brzostek, J., Artyomov, M. N., Abel, S. M., Casas, J., Rybakin, V., Ampudia, J., Lotz, C., Connolly, J. M., Chakraborty, A. K., Gould, K. G., Gascoigne, N. R. J. Coreceptor affinity for MHC defines peptide specificity requirements for TCR interaction with coagonist peptide-MHC Journal of Experimental Medicine 2013 210:1807-1821 DOI:10.1084/jem.20122528 PMID:23940257 PMCID:PMC3754861
- Paster, W., Brockmeyer, C., Fu, G., Simister, P. C., de Wet, B., Martinez-Riano, A., Hoerter, J. A. H., Feller, S. M., Wulfing, C., Gascoigne, N. R. J., Acuto, O. GRB2-mediated recruitment of THEMIS to LAT is essential for thymocyte development Journal of Immunology 2013 190:3749-3756 DOI:10.4049/jimmunol.1203389 PMID:23460737 PMCID:PMC3607403
- Rybakin, V., Gascoigne, N. R. J. Negative selection assay based on stimulation of t cell receptor transgenic thymocytes with peptide-mhc tetramers PLoS One 2012 7:e43191 DOI:10.1371/journal.pone.0043191 PMID:22900100 PMCID:PMC3416795
- Fu, G., Hu, J. F., Niederberger-Magnenat, N., Rybakin, V., Casas, J., Yachi, P. P., Feldstein, S., Ma, B., Hoerter, J. A. H., Ampudia, J., Rigaud, S., Lambolez, F., et al. Protein kinase C η is required for T cell activation and homeostatic proliferation Science Signaling 2011 4:ra84 DOI:10.1126/scisignal.2002058 PMID:22155788 PMCID:PMC3242502
- Rybakin, V., Clamme, J. P., Ampudia, J., Yachi, P. P., Gascoigne, N. R. J. CD8αα and ‐αβ isotypes are equally recruited to the immunological synapse through their ability to bind to MHC class I EMBO Reports 2011 12:1251-1256 DOI:10.1038/embor.2011.209 PMID:22081144 PMCID:PMC3245696
- Gascoigne, N. R. J., Palmer, E. Signaling in thymic selection Current Opinion in Immunology 2011 23:207-212 DOI:10.1016/j.coi.2010.12.017 PMID:21242076 PMCID:PMC3073816
- Brockmeyer, C., Paster, W., Pepper, D., Tan, C. P., Trudgian, D. C., McGowan, S., Fu, G., Gascoigne, N. R. J., Acuto, O., Salek, M. T cell receptor (TCR)-induced tyrosine phosphorylation dynamics identifies THEMIS as a new TCR signalosome component Journal of Biological Chemistry 2011 286:7535-7547 DOI:10.1074/jbc.M110.201236 PMID:21189249 PMCID:PMC3045008
- Gascoigne, N. R. J., Zal, T., Yachi, P. P., Hoerter, J. A. H. Co-receptors and recognition of self at the immunological synapse Current Topics in Microbiology and Immunology 2010 340:171-189 DOI:10.1007/978-3-642-03858-7_9 PMID:19960314
- Fu, G., Gascoigne, N. R. J. Multiplexed labeling of samples with cell tracking dyes facilitates rapid and accurate internally controlled calcium flux measurement by flow cytometry Journal of Immunological Methods 2009 350:194-199 DOI:10.1016/j.jim.2009.07.009 PMID:19647745 PMCID:PMC2782925
- Fu, G., Vallee, S., Rybakin, V., McGuire, M. V., Ampudia, J., Brockmeyer, C., Salek, M., Fallen, P. R., Hoerter, J. A. H., Munshi, A., Huang, Y. H., Hu, J. F., et al. Themis controls thymocyte selection through regulation of t cell antigen receptor-mediated signaling Nature Immunology 2009 10:848-856 DOI:10.1038/ni.1766 PMID:19597499 PMCID:PMC2757056
- Singleton, K. L., Roybal, K. T., Sun, Y., Fu, G., Gascoigne, N. R. J., van Oers, N. S. C., Wulfing, C. Spatiotemporal patterning during t cell activation is highly diverse Science Signaling 2009 2:ra15 DOI:10.1126/scisignal.2000199 PMID:19351954 PMCID:PMC2694444
- Gascoigne, N. R. J., Ampudia, J., Clamme, J. P., Fu, G., Lotz, C., Mallaun, M., Niederberger, N., Palmer, E., Rybakin, V., Yachi, P. P., Zal, T. Visualizing intermolecular interactions in T cells Current Topics in Microbiology and Immunology 2009 334:31-46 DOI:10.1007/978-3-540-93864-4_2 PMID:19521680 PMCID:PMC3079427
- Gascoigne, N. R. J. Do t cells need endogenous peptides for activation? Nature Reviews Immunology 2008 8:895-900 DOI:10.1038/nri2431 PMID:18846098
- Mallaun, M., Naeher, D., Daniels, M. A., Yachi, P. P., Hausmann, B., Luescher, I. F., Gascoigne, N. R. J., Palmer, E. The T cell receptor's α-chain connecting peptide motif promotes close approximation of the CD8 coreceptor allowing efficient signal initiation Journal of Immunology 2008 180:8211-8221 PMID:18523287 PMCID:PMC2764738
- Haraldsson, M. K., Louis-Dit-Sully, C. A., Lawson, B. R., Sternik, G., Santiago-Raber, M. L., Gascoigne, N. R. J., Theofilopoulos, A. N., Kono, D. H. The lupus-related Lmb3 locus contains a disease-suppressing coronin-1A gene mutation Immunity 2008 28:40-51 DOI:10.1016/j.immuni.2007.11.023 PMID:18199416 PMCID:PMC2274909
- Yachi, P. P., Lotz, C., Ampudia, J., Gascoigne, N. R. J. T cell activation enhancement by endogenous pMHC acts for both weak and strong agonists but varies with differentiation state Journal of Experimental Medicine 2007 204:2747-2757 DOI:10.1084/jem.20062610 PMID:17954567 PMCID:PMC2118480
- Daniels, M. A., Teixeiro, E., Gill, J., Hausmann, B., Roubaty, D., Holmberg, K., Werlen, G., Hollander, G. A., Gascoigne, N. R. J., Palmer, E. Thymic selection threshold defined by compartmentalization of ras/mapk signalling Nature 2006 444:724-729 DOI:10.1038/nature05269 PMID:17086201
- Zal, T., Zal, M. A., Lotz, C., Goergen, C. J., Gascoigne, N. R. J. Spectral shift of fluorescent dye fm4-64 reveals distinct microenvironment of nuclear envelope in living cells Traffic 2006 7:1607-1613 DOI:10.1111/j.1600-0854.2006.00498.x PMID:17052249
- Zambricki, E., Zal, T., Yachi, P., Shigeoka, A., Sprent, J., Gascoigne, N., McKay, D. In vivo anergized T cells form altered immunological synapses in vitro American Journal of Transplantation 2006 6:2572-2579 DOI:10.1111/j.1600-6143.2006.01517.x PMID:16952297
- Yachi, P. P., Ampudia, J., Zal, T., Gascoigne, N. R. J. Altered peptide ligands induce delayed CD8-T cell receptor interaction--a role for CD8 in distinguishing antigen quality Immunity 2006 25:203-211 DOI:10.1016/j.immuni.2006.05.015 PMID:16872849
- Bosco, N., Hung, H. C., Pasqual, N., Jouvin-Marche, E., Marche, P. N., Gascoigne, N. R. J., Ceredig, R. Role of the t cell receptor alpha chain in the development and phenotype of naturally arising cd4(+)cd25(+) t cells Molecular Immunology 2006 43:246-254 DOI:10.1016/j.molimm.2005.02.002 PMID:16199261
- Yachi, P. P., Ampudia, J., Gascoigne, N. R. J., Zal, T. Nonstimulatory peptides contribute to antigen-induced CD8-T cell receptor interaction at the immunological synapse Nature Immunology 2005 6:785-792 DOI:10.1038/ni1220 PMID:15980863 PMCID:PMC1352171
- Lin, M. Y., Zal, T., Ch'en, I. L., Gascoigne, N. R. J., Hedrick, S. M. A pivotal role for the multifunctional calcium/calmodulin-dependent protein kinase ii in t cells: From activation to unresponsiveness Journal of Immunology 2005 174:5583-5592 PMID:15843557
- Niederberger, N., Buehler, L. K., Ampudia, J., Gascoigne, N. R. J. Thymocyte stimulation by anti-tcr-beta, but not by anti-tcr-alpha, leads to induction of developmental transcription program Journal of Leukocyte Biology 2005 77:830-841 DOI:10.1189/jlb.1004608 PMID:15661827
- Gronski, M. A., Boulter, J. M., Moskophidis, D., Nguyen, L. T., Holmberg, K., Elford, A. R., Deenick, E. K., Kim, H. O., Penninger, J. M., Odermatt, B., Gallimore, A., Gascoigne, N. R. J., et al. Tcr affinity and negative regulation limit autoimmunity Nature Medicine 2004 10:1234-1239 DOI:10.1038/nm1114 PMID:15467726
- Santori, F. R., Holmberg, K., Ostrov, D., Gascoigne, N. R. J., Vukmanovic, S. Distinct footprints of tcr engagement with highly homologous ligands Journal of Immunology 2004 172:7466-7475 PMID:15187125
- Gascoigne, N. R. J., Zal, T. Molecular interactions at the t cell-antigen-presenting cell interface Current Opinion in Immunology 2004 16:114-119 DOI:10.1016/j.coi.2003.11.008 PMID:14734119
- Zal, T., Gascoigne, N. R. J. Photobleaching-corrected fret efficiency imaging of live cells Biophysical Journal 2004 86:3923-3939 DOI:10.1529/biophysj.103.022087 PMID:15189889 PMCID:PMC1304294
- Zal, T., Gascoigne, N. R. Using live fret imaging to reveal early protein-protein interactions during t cell activation Current Opinion in Immunology 2004 16:418-427 DOI:10.1016/j.coi.2004.05.019 PMID:15245734
- Holmberg, K., Mariathasan, S., Ohteki, T., Ohashi, P. S., Gascoigne, N. R. J. Tcr binding kinetics measured with mhc class i tetramers reveal a positive selecting peptide with relatively high affinity for tcr Journal of Immunology 2003 171:2427-2434 PMID:12928390
- Niederberger, N., Holmberg, K., Alam, S. M., Sakati, W., Naramura, M., Gu, H., Gascoigne, N. R. J. Allelic exclusion of the tcr alpha-chain is an active process requiring tcr-mediated signaling and c-cbl Journal of Immunology 2003 170:4557-4563 PMID:12707333
- Sim, B. C., Holmberg, K., Sidobre, S., Naidenko, O., Niederberger, N., Marine, S. D., Kronenberg, M., Gascoigne, N. R. J. Surprisingly minor influence of trav11 (v alpha 14) polymorphism on nk t-receptor mcd1/alpha-galactosylceramide binding kinetics Immunogenetics 2003 54:874-883 DOI:10.1007/s00251-002-0532-y PMID:12671739
- Sidobre, S., Naidenko, O. V., Sim, B. C., Gascoigne, N. R. J., Garcia, K. C., Kronenberg, M. The v alpha 14 nkt cell tcr exhibits high-affinity binding to a glycolipid/cd1d complex Journal of Immunology 2002 169:1340-1348 PMID:12133957
- Huang, J. Y., Lo, P. F., Zal, T., Gascoigne, N. R. J., Smith, B. A., Levin, S. D., Grey, H. M. Cd28 plays a critical role in the segregation of pkc theta within the immunologic synapse Proceedings of the National Academy of Sciences of the United States of America 2002 99:9369-9373 DOI:10.1073/pnas.142298399 PMID:12077322 PMCID:PMC123147
- Zal, T., Zal, M. A., Gascoigne, N. R. J. Inhibition of t cell receptor-coreceptor interactions by antagonist ligands visualized by live fret imaging of the t-hybridoma immunological synapse Immunity 2002 16:521-534 DOI:10.1016/s1074-7613(02)00301-1 PMID:11970876
- McGuire, M. V., Suthipinijtham, P., Gascoigne, N. R. J. The mouse supt16h/fact140 gene, encoding part of the fact chromatin transcription complex, maps close to tcra and is highly expressed in thymus Mammalian Genome 2001 12:664-667 DOI:10.1007/s003350020036 PMID:11471063
- Rosette, C., Werlen, G., Daniels, M. A., Holman, P. O., Alam, S. M., Travers, P. J., Gascoigne, N. R. J., Palmer, E., Jameson, S. C. The impact of duration versus extent of tcr occupancy on t cell activation: A revision of the kinetic proofreading model Immunity 2001 15:59-70 DOI:10.1016/s1074-7613(01)00173-x PMID:11485738
- Redpath, S., Ghazal, P., Gascoigne, N. R. J. Hijacking and exploitation of il-10 by intracellular pathogens Trends in Microbiology 2001 9:86-92 DOI:10.1016/s0966-842x(00)01919-3 PMID:11173248
- Redpath, S., Angulo, A., Gascoigne, N. R. J., Ghazal, P. Immune checkpoints in viral latency Annual Review of Microbiology 2001 55:531-560 DOI:10.1146/annurev.micro.55.1.531 PMID:11544366
- Gascoigne, N. R. J., Alam, S. M., Lin, C. M., McGuire, M. V., Marine, S., Niederberger, N., Redpath, S., Sim, B. C., Travers, P. J., Yachi, P., Zal, M. A., Zal, T. T cell receptor binding kinetics and special role of Vα in T cell development and activation Immunologic Research 2000 21:225-231 DOI:10.1385/ir:21:2-3:225 PMID:10852121
- Gascoigne, N. R. J., Alam, S. M. Allelic exclusion of the t cell receptor alpha-chain: Developmental regulation of a post-translational event Seminars in Immunology 1999 11:337-347 DOI:10.1006/smim.1999.0190 PMID:10497088
- Redpath, S., Alam, S. M., Lin, C. M., O'Rourke, A. M., Gascoigne, N. R. J. Cutting edge: Trimolecular interaction of tcr with mhc class ii and bacterial superantigen shows a similar affinity to mhc : Peptide ligands Journal of Immunology 1999 163:6-10 PMID:10384091
- Redpath, S., Angulo, A., Gascoigne, N. R. J., Ghazal, P. Murine cytomegalovirus infection down-regulates mhc class ii expression on macrophages by induction of il-10 Journal of Immunology 1999 162:6701-6707 PMID:10352288
- Sim, B. C., Gascoigne, N. R. J. Reciprocal expression in cd4 or cd8 subsets of different members of the v alpha 11 gene family correlates with sequence polymorphism Journal of Immunology 1999 162:3153-3159 PMID:10092765
- Alam, S. M., Davies, G. M., Lin, C. M., Zal, T., Nasholds, W., Jameson, S. C., Hogquist, K. A., Gascoigne, N. R. J., Travers, P. J. Qualitative and quantitative differences in t cell receptor binding of agonist and antagonist ligands Immunity 1999 10:227-237 DOI:10.1016/s1074-7613(00)80023-0 PMID:10072075
- Sim, B. C., Aftahi, N., Reilly, C., Bogen, B., Schwartz, R. H., Gascoigne, N. R. J., Lo, D. Thymic skewing of the cd4/cd8 ratio maps with the t-cell receptor alpha-chain locus Current Biology 1998 8:701-704 DOI:10.1016/s0960-9822(98)70276-3 PMID:9637921
- Sim, B. C., Lo, D., Gascoigne, N. R. J. Preferential expression of tcr v alpha regions in cd4/cd8 subsets: Class discrimination or co-receptor recognition? Immunology Today 1998 19:276-282 DOI:10.1016/s0167-5699(98)01257-2 PMID:9639993
- Alam, S. M., Gascoigne, N. R. J. Posttranslational regulation of tcr v alpha allelic exclusion during t cell differentiation Journal of Immunology 1998 160:3883-3890 PMID:9558094
- Sim, B. C., Wung, J. L., Gascoigne, N. R. J. Polymorphism within a tcrav family influences the repertoire through class i/ii restriction Journal of Immunology 1998 160:1204-1211 PMID:9570535
- Gascoigne, N. R. J. Natural killer cells: Influence of the home environment Current Biology 1997 7:R624-R626 DOI:10.1016/s0960-9822(06)00318-6 PMID:9368742
- Sim, B. C., Travers, P. J., Gascoigne, N. R. J. V alpha 3.2 selection in mhc class i mutant mice - evidence for an alternate orientation of tcr-mhc class i interaction Journal of Immunology 1997 159:3322-3329 PMID:9317130
- Wung, J. L., Gascoigne, N. R. J. Selection of phage-displayed superantigen by binding to cell-surface mhc class ii Journal of Immunological Methods 1997 204:33-41 DOI:10.1016/s0022-1759(97)00038-0 PMID:9202707
- Wung, J. L., Gascoigne, N. R. J. Antibody screening for secreted proteins expressed in pichia pastoris Biotechniques 1996 21:808, 810, 812 PMID:8922617
- Sim, B. C., Zerva, L., Greene, M. I., Gascoigne, N. R. J. Control of mhc restriction by tcr v-alpha cdr1 and cdr2 Science 1996 273:963-966 DOI:10.1126/science.273.5277.963 PMID:8688082
- Alam, S. M., Travers, P. J., Wung, J. L., Nasholds, W., Redpath, S., Jameson, S. C., Gascoigne, N. R. J. T-cell-receptor affinity and thymocyte positive selection Nature 1996 381:616-620 DOI:10.1038/381616a0 PMID:8637599
- Alam, S. M., Crispe, I. N., Gascoigne, N. R. J. Allelic exclusion of mouse t-cell receptor-alpha chains occurs at the time of thymocyte tcr up-regulation Immunity 1995 3:449-458 PMID:7584136
- Alam, S. M., Sim, B. C., Gascoigne, N. R. J. Selection of tcr v-alpha by mhc class-ii predicts superantigen reactivity International Immunology 1995 7:1311-1318 DOI:10.1093/intimm/7.8.1311 PMID:7495738
- Dohlsten, M., Abrahmsen, L., Bjork, P., Lando, P. A., Hedlund, G., Forsberg, G., Brodin, T., Gascoigne, N. R. J., Forberg, C., Lind, P., Kalland, T. Monoclonal antibody-superantigen fusion proteins - tumor-specific agents for t-cell-based tumor-therapy Proceedings of the National Academy of Sciences of the United States of America 1994 91:8945-8949 DOI:10.1073/pnas.91.19.8945 PMID:8090750
- Webb, S. R., Gascoigne, N. R. J. T-cell activation by superantigens Current Opinion in Immunology 1994 6:467-475 DOI:10.1016/0952-7915(94)90129-5 PMID:7917116
- Irwin, M. J., Gascoigne, N. R. J. Interplay between superantigens and the immune-system Journal of Leukocyte Biology 1993 54:495-503 PMID:8228628
- Gascoigne, N. R. J. What role does the alpha-chain play in recognition of superantigens Research in Immunology 1993 144:184-187 DOI:10.1016/0923-2494(93)80115-f PMID:7694343
- Irwin, M. J., Hudson, K. R., Ames, K. T., Fraser, J. D., Gascoigne, N. R. J. T-cell receptor beta-chain binding to enterotoxin superantigens Immunological Reviews 1993 131:61-78 DOI:10.1111/j.1600-065X.1993.tb01530.x PMID:8486394
- Irwin, M. J., Hudson, K. R., Fraser, J. D., Gascoigne, N. R. J. Enterotoxin residues determining t-cell receptor v-beta binding-specificity Nature 1992 359:841-843 DOI:10.1038/359841a0 PMID:1436060
- Pontzer, C. H., Irwin, M. J., Gascoigne, N. R. J., Johnson, H. M. T-cell antigen receptor-binding sites for the microbial superantigen staphylococcal enterotoxin-a Proceedings of the National Academy of Sciences of the United States of America 1992 89:7727-7731 DOI:10.1073/pnas.89.16.7727 PMID:1502191
- Nakajima, P. B., Divincenzo, J. P., Jameson, S. C., Gascoigne, N. R. J. Chromosome-14 in b10.A(18r) mice is recombinant and includes tcra-va alleles Immunogenetics 1992 35:190-198 PMID:1371499
- Gahm, S. J., Fowlkes, B. J., Jameson, S. C., Gascoigne, N. R. J., Cotterman, M. M., Kanagawa, O., Schwartz, R. H., Matis, L. A. Profound alteration in an alpha-beta t-cell antigen receptor repertoire due to polymorphism in the 1st complementarity-determining region of the beta-chain Proceedings of the National Academy of Sciences of the United States of America 1991 88:10267-10271 DOI:10.1073/pnas.88.22.10267 PMID:1835090
- Jameson, S. C., Nakajima, P. B., Brooks, J. L., Heath, W., Kanagawa, O., Gascoigne, N. R. J. The t-cell receptor v-alpha-11 gene family - analysis of allelic sequence polymorphism and demonstration of j-alpha region-dependent recognition by allele-specific antibodies Journal of Immunology 1991 147:3185-3193 PMID:1717591
- Gascoigne, N. R. J., Ames, K. T. Direct binding of secreted t-cell receptor beta chain to superantigen associated with class-ii major histocompatibility complex protein Proceedings of the National Academy of Sciences of the United States of America 1991 88:613-616 DOI:10.1073/pnas.88.2.613 PMID:1824876
- Jameson, S. C., Kaye, J., Gascoigne, N. R. J. A t-cell receptor-v-alpha region selectively expressed in cd4+ cells Journal of Immunology 1990 145:1324-1331 PMID:1696594
- Gascoigne, N. R. J. Transport and secretion of truncated t-cell receptor beta-chain occurs in the absence of association with cd3 Journal of Biological Chemistry 1990 265:9296-9301 PMID:2140571
- Kaye, J., Hsu, M. L., Sauron, M. E., Jameson, S. C., Gascoigne, N. R. J., Hedrick, S. M. Selective development of cd4+ t-cells in transgenic mice expressing a class-ii mhc-restricted antigen receptor Nature 1989 341:746-749 DOI:10.1038/341746a0 PMID:2571940
- Gascoigne, N. R. J., Goodnow, C. C., Dudzik, K. I., Oi, V. T., Davis, M. M. Secretion of a chimeric t-cell receptor immunoglobulin protein Proceedings of the National Academy of Sciences of the United States of America 1987 84:2936-2940 DOI:10.1073/pnas.84.9.2936 PMID:3472243
- Gascoigne, N. R. J., Waters, S., Elliott, J. F., Victorkobrin, C., Goodnow, C., Davis, M. M., Bona, C. A. Expression of t-cell receptor genes in an antigen-specific hybridoma and radiation-induced variants Journal of Experimental Medicine 1986 164:113-130 DOI:10.1084/jem.164.1.113 PMID:2425026
- Davis, M. M., Lindsten, T., Gascoigne, N. R. J., Goodnow, C., Chien, Y. H. T-cell receptor gene structure and function Cellular Immunology 1986 99:24-28 DOI:10.1016/0008-8749(86)90211-x PMID:3489561
- Davis, M. M., Lindsten, T., Gascoigne, N. R. J., Goodnow, C., Chien, Y. H. Paradigm regained - similarities and differences between t-cell receptor and immunoglobulin genes Biochemical Society Symposium 1986 205-209
- Hedrick, S. M., Germain, R. N., Bevan, M. J., Dorf, M., Engel, I., Fink, P., Gascoigne, N., Heberkatz, E., Kapp, J., Kaufmann, Y., Kaye, J., Melchers, F., et al. Rearrangement and transcription of a t-cell receptor beta-chain gene in different t-cell subsets Proceedings of the National Academy of Sciences of the United States of America 1985 82:531-535 DOI:10.1073/pnas.82.2.531 PMID:2578667
- Becker, D. M., Patten, P., Chien, Y. H., Yokota, T., Eshhar, Z., Giedlin, M., Gascoigne, N. R. J., Goodnow, C., Wolf, R., Arai, K., Davis, M. M. Variability and repertoire size of t-cell receptor v-alpha gene segments Nature 1985 317:430-434 DOI:10.1038/317430a0 PMID:2995827
- Davis, M. M., Chien, Y., Gascoigne, N. R. J., Hedrick, S. M. A murine t-cell receptor gene-complex - isolation, structure and rearrangement Immunological Reviews 1984 81:235-258 DOI:10.1111/j.1600-065X.1984.tb01113.x PMID:6096259
- Crispe, I. N., Gascoigne, N. R. J., Owens, T. An allospecific murine T helper clone which can help both T and B cell responses in vitro and in vivo Immunology 1984 52:55-65 PMID:6232208 PMCID:PMC1454605
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