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Franc, Nathalie
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Franc, Nathalie

Faculty Member
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Positions

  • 2017 - Associate Professor, Molecular Medicine , Scripps Research
  • 2009 - Faculty Member, Skaggs Graduate School of Chemical and Biological Sciences , Scripps Research
  • 2016 - 2017 Associate Professor (Joint Appointment), Immunology and Microbial Science (IMS) , Scripps Research
  • 2016 - 2017 Associate Professor, Cell and Molecular Biology (CMB) , Scripps Research
  • 2013 - 2016 Assistant Professor (Joint Appointment), Immunology and Microbial Science (IMS) , Scripps Research
  • 2013 - 2016 Assistant Professor, Cell and Molecular Biology (CMB) , Scripps Research
  • 2009 - 2011 Assistant Professor, Genetics , Scripps Research
Dr. Nathalie Franc studies phagocytosis, the process by which dying cells are recognized and cleared during embryogenesis in the fruit fly, Drosophila melanogaster. Her long-term goal is to compare its molecular mechanisms with that of phagocytosis of pathogens, such as bacteria.

Research Areas research areas

  • Alzheimer (UMLS)

Contact

  • nfranc@scripps.edu

Websites

  • Nathalie Franc, Ph.D.
  • Laboratory Website
  • Publications
  • Research
  • Background
  • Contact
  • Identity
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Publications

recent publications
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  • academic article

    • Schwartz, R., Guichard, A., Franc, N. C., Roy, S., Bier, E. A drosophila model for clostridium difficile toxin CDT reveals interactions with multiple effector pathways iScience  2020 23  DOI:10.1016/j.isci.2020.100865  PMID:32058973  PMCID:PMC7011083
    • Zheng, Q., Ma, A., Yuan, L., Gao, N., Feng, Q., Franc, N. C., Xiao, H. Apoptotic cell clearance in Drosophila melanogaster Frontiers in Immunology  2017 8  DOI:10.3389/fimmu.2017.01881
    • Guillou, A., Troha, K., Wang, H., Franc, N. C., Buchon, N. The Drosophila CD36 homologue croquemort is required to maintain immune and gut homeostasis during development and aging PLoS Pathogens  2016 12  DOI:10.1371/journal.ppat.1005961  PMID:27780230  PMCID:PMC5079587
    • Meehan, T. L., Joudi, T. F., Timmons, A. K., Taylor, J. D., Habib, C. S., Peterson, J. S., Emmanuel, S., Franc, N. C., McCall, K. Components of the engulfment machinery have distinct roles in corpse processing PLoS One  2016 11  DOI:10.1371/journal.pone.0158217  PMID:27347682  PMCID:PMC4922577
    • Xiao, H., Wang, H., Silva, E. A., Thompson, J., Guillou, A., Yates III, J. R., Buchon, N., Franc, N. C. The Pallbearer E3 ligase promotes actin remodeling via RAC in efferocytosis by degrading the ribosomal protein S6 Developmental Cell  2015 32:19-30  DOI:10.1016/j.devcel.2014.11.015  PMID:25533207  PMCID:PMC4293263
    • Han, C., Song, Y., Xiao, H., Wang, D., Franc, N. C., Jan, L. Y., Jan, Y. N. Epidermal cells are the primary phagocytes in the fragmentation and clearance of degenerating dendrites in Drosophila Neuron  2014 81:544-560  DOI:10.1016/j.neuron.2013.11.021  PMID:24412417  PMCID:PMC3995171
    • Van Goethem, E., Silva, E. A., Xiao, H., Franc, N. C. The Drosophila TRPP cation channel, PKD2 and Dmel/Ced-12 act in genetically distinct pathways during apoptotic cell clearance PLoS One  2012 7:e31488  DOI:10.1371/journal.pone.0031488  PMID:22347485  PMCID:PMC3275576
    • Gronski, M. A., Kinchen, J. M., Juncadella, I. J., Franc, N. C., Ravichandran, K. S. An essential role for calcium flux in phagocytes for apoptotic cell engulfment and the anti-inflammatory response Cell Death and Differentiation  2009 16:1323-1331  DOI:10.1038/cdd.2009.55  PMID:19461656  PMCID:PMC2856475
    • Cuttell, L., Vaughan, A., Silva, E., Escaron, C. J., Lavine, M., Van Goethem, E., Eid, J. P., Quirin, M., Franc, N. C. Undertaker, a Drosophila Junctophilin, links Draper-mediated phagocytosis and calcium homeostasis Cell  2008 135:524-534  DOI:10.1016/j.cell.2008.08.033  PMID:18984163
    • Silva, E. A., Burden, J., Franc, N. C. In vivo and in vitro methods for studying apoptotic cell engulfment in Drosophila Methods in Enzymology  2008 446:39-59  DOI:10.1016/s0076-6879(08)01603-0  PMID:18603115
    • Silva, E., Au-Yeung, H. W., Van Goethem, E., Burden, J., Franc, N. C. Requirement for a Drosophila E3-ubiquitin ligase in phagocytosis of apoptotic cells Immunity  2007 27:585-596  DOI:10.1016/j.immuni.2007.08.016  PMID:17936033
    • Franc, N. C. Phagocytosis of apoptotic cells in mammals, Caenorhabditis elegans and Drosophila melanogaster: molecular mechanisms and physiological consequences Frontiers in Bioscience  2002 7:D1298-D1313  DOI:10.2741/franc  PMID:11991836
    • White, K., Lisi, S., Kurada, P., Franc, N., Bangs, P. Methods for studying apoptosis and phagocytosis of apoptotic cells in Drosophila tissues and cell lines Methods in Cell Biology  2001 66:321-338  DOI:10.1016/S0091-679X(01)66015-1  PMID:11396010
    • Bangs, P., Franc, N., White, K. Molecular mechanisms of cell death and phagocytosis in Drosophila Cell Death and Differentiation  2000 7:1027-1034  DOI:10.1038/sj.cdd.4400754  PMID:11139274
    • Franc, N. C., White, K. Innate recognition systems in insect immunity and development: new approaches in Drosophila Microbes and Infection  2000 2:243-250  DOI:10.1016/s1286-4579(00)00304-x  PMID:10758400
    • Franc, N. C., Heitzler, P., Ezekowitz, R. A. B., White, K. Requirement for croquemort in phagocytosis of apoptotic cells in Drosophila Science  1999 284:1991-1994  DOI:10.1126/science.284.5422.1991  PMID:10373118
    • Franc, N. C., White, K., Ezekowitz, R. A. B. Phagocytosis and development: back to the future Current Opinion in Immunology  1999 11:47-52  DOI:10.1016/s0952-7915(99)80009-0  PMID:10047544
    • Franc, N. C., Dimarcq, J. L., Lagueux, M., Hoffmann, J., Ezekowitz, R. A. B. Croquemort, a novel Drosophila hemocyte/macrophage receptor that recognizes apoptotic cells Immunity  1996 4:431-443  DOI:10.1016/s1074-7613(00)80410-0  PMID:8630729
  • thesis

    • Croquemort, un recepteur hemocytaire qui participe a la phagocytose de cellules apoptotiques chez Drosophila melanogaster [Croquemort, a receptor that participates in hemocyte phagocytosis of apoptotic cells in Drosophila melanogaster] 1996
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Research

research overview

  • Our laboratory studies the process by which cells that are dying by apoptosis are recognized and cleared during the course of embryonic development in the fruit fly, Drosophila melanogaster. Our long-term goal is to compare and contrast the molecular mechanisms of phagocytosis of apoptotic cells with that of pathogens, such as bacteria. Failure to clear apoptotic cells has been associated with autoimmune diseases, such as Lupus Erythematosus, and may also contribute to neurogenerative disorders. Thus, our studies will increase our basic understanding of phagocytosis, an important aspect of the innate cellular immune response and development of all multicellular organisms, and ultimately contribute to the design of new drugs to treat diseases associated with failed apoptotic cell clearance, as well as bacterial infections.
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Background

education and training

  • Ph.D. in Molecular and Cell Biology, Louis Pasteur University , with Dr. Jules Hoffmann 1996
  • M.S. in Molecular and Cell Biology, Louis Pasteur University 1992
  • B.S. in Cell Biology and Physiology, Paul Sabatier University 1990
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Contact

full name

  • Nathalie C. Franc

geographic location

  • Scripps California 
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Identity

ORCID iD

  • ORCID iD http://orcid.org/0000-0002-1617-385X

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