recent publications
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academic article
- Pahwa, S., Bhowmick, M., Amar, S., Cao, J., Strongin, A. Y., Fridman, R., Weiss, S. J., Fields, G. B. Characterization and regulation of MT1-MMP cell surface-associated activity Chemical Biology & Drug Design 2019 93:1251-1264 DOI:10.1111/cbdd.13450 PMID:30480376 PMCID:PMC6536371
- Marcink, T. C., Simoncic, J. A., An, B., Knapinska, A. M., Fulcher, Y. G., Akkaladevi, N., Fields, G. B., Van Doren, S. R. MT1-MMP binds membranes by opposite tips of its β propeller to position it for pericellular proteolysis Structure 2019 27:281-292 DOI:10.1016/j.str.2018.10.008 PMID:30471921 PMCID:PMC6365218
- Karabencheva-Christova, T. G., Christov, C. Z., Fields, G. B. Conformational dynamics of matrix metalloproteinase-1.triple-helical peptide complexes Journal of Physical Chemistry B 2018 122:5316-5326 DOI:10.1021/acs.jpcb.7b09771 PMID:29161042
- Fuerst, R., Yong Choi, J., Knapinska, A. M., Smith, L., Cameron, M. D., Ruiz, C., Fields, G. B., Roush, W. R. Development of matrix metalloproteinase-13 inhibitors - A structureactivity/structure-property relationship study Bioorganic & Medicinal Chemistry 2018 26:4984-4995 DOI:10.1016/j.bmc.2018.08.020 PMID:30249495
- Tokmina-Roszyk, M., Fields, G. B. Dissecting MMP P-10 and P-11 subsite sequence preferences, utilizing a positional scanning, combinatorial triple-helical peptide library Journal of Biological Chemistry 2018 293:16661-16676 DOI:10.1074/jbc.RA118.003266 PMID:30185620 PMCID:PMC6204916
- Stawikowski, M. J., Fields, G. B. Tricine as a convenient scaffold for the synthesis of C-terminally branched collagen-model peptides Tetrahedron Letters 2018 59:130-134 DOI:10.1016/j.tetlet.2017.12.008
- Amar, S., Smith, L., Fields, G. B. Matrix metalloproteinase collagenolysis in health and disease Biochimica Et Biophysica Acta-Molecular Cell Research 2017 1864:1940-1951 DOI:10.1016/bbamcr.2017.04.015 PMID:28456643 PMCID:PMC5605394
- Choi, J. Y., Fuerst, R., Knapinska, A. M., Taylor, A. B., Smith, L., Cao, X., Hart, P. J., Fields, G. B., Roush, W. R. Structure-based design and synthesis of potent and selective matrix metalloproteinase 13 inhibitors Journal of Medicinal Chemistry 2017 60:5816-5825 DOI:10.1021/acs.jmedchem.7b00514 PMID:28653849
- Knapinska, A. M., Estrada, C. A., Fields, G. B. The roles of matrix metalloproteinases in pancreatic cancer Progress in Molecular Biology and Translational Science 2017 148:339-354 DOI:10.1016/bs.pmbts.2017.03.004 PMID:28662827
- Singh, W., Fields, G. B., Christov, C. Z., Karabencheva-Christova, T. G. Effects of mutations on structure-function relationships of matrix metalloproteinase-1 International Journal of Molecular Sciences 2016 17 DOI:10.3390/ijms17101727 PMID:27754420 PMCID:PMC5085758
- Jiang, J., Taylor, A. B., Choi, J. Y., Hart, P. J., Roush, W. R., Fields, G. B., Hodder, P. S., Minong, D., Spicer, T. P. Characterization of selective exosite-binding inhibitors of matrix metalloproteinase 13 that prevent articular cartilage degradation in vitro Journal of Medicinal Chemistry 2014 57:9598-9611 DOI:10.1021/jm501284e PMID:25330343 PMCID:PMC4255739
- Madoux, F., Tredup, C., Scampavia, L., Chase, P. S., Hodder, P. S., Fields, G. B., Becker-Pauly, C., Minond, D., Spicer, T. P. Development of high throughput screening assays and pilot screen for inhibitors of metalloproteases meprin α and β Biopolymers 2014 102:396-406 DOI:10.1002/bip.22527 PMID:25048711 PMCID:PMC4339026
- Roth, J., Minond, D., Darout, E., Liu, Q., Lauer, J., Hodder, P., Fields, G. B., Roush, W. R. Identification of novel, exosite-binding matrix metalloproteinase-13 inhibitor scaffolds Bioorganic & Medicinal Chemistry Letters 2011 21:7180-7184 DOI:10.1016/j.bmcl.2011.09.077 PMID:22018790 PMCID:PMC3210410
- Lauer-Fields, J. L., Minond, D., Chase, P. S., Baillargeon, P. E., Saldanha, S. A., Stawikowska, R., Hodder, P., Fields, G. B. High throughput screening of potentially selective mmp-13 exosite inhibitors utilizing a triple-helical fret substrate Bioorganic & Medicinal Chemistry 2009 17:990-1005 DOI:10.1016/j.bmc.2008.03.004 PMID:18358729 PMCID:PMC3298815
- Lauer-Fields, J. L., Chalmers, M. J., Busby, S. A., Minond, D., Griffin, P. R., Fields, G. B. Identification of specific hemopexin-like domain residues that facilitate matrix metalloproteinase collagenolytic activity Journal of Biological Chemistry 2009 284:24017-24024 DOI:10.1074/jbc.M109.016873 PMID:19574232 PMCID:PMC2781996
- Lauer-Fields, J. L., Spicer, T. P., Chase, P. S., Cudic, M., Burstein, G. D., Nagase, H., Hodder, P., Fields, G. B. Screening of potential a, disintegrin and metalloproteinase with thrombospondin motifs-4 inhibitors using a collagen model fluorescence resonance energy transfer substrate Analytical Biochemistry 2008 373:43-51 DOI:10.1016/j.ab.2007.09.014 PMID:17949675 PMCID:PMC2245870
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chapter
- Tagged Karabencheva-Christova, T. G., Christov, C. Z., Fields, G. B. Collagenolytic matrix metalloproteinase structure-function relationships: insights from molecular dynamics studies Structural and Mechanistic Enzymology. 1-24. 2017 DOI:10.1016/bs.apcsb.2017.04.001