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Fields, Gregg
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Fields, Gregg

Faculty Member Adjunct
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Positions

  • 2014 - Chair, Department of Chemistry & Biochemistry, Florida Atlantic University
  • 2014 - Professor, Department of Chemistry & Biochemistry, Florida Atlantic University
  • 2005 - Professor Adjunct, Chemistry , Scripps Research
  • 2010 - 2014 Vice President of Scientific Affairs, Torrey Pines Institute for Molecular Studies
  • 1997 - 2008 Professor and Chair, Florida Atlantic University
  • 1995 - 1997 Associate Professor, University of Minnesota Medical Center , University of Minnesota
  • 1991 - 1995 Assistant Professor, University of Minnesota Medical Center , University of Minnesota
  • 1988 - 1991 Postdoctoral Scholar, Pharmaceutical Chemistry, School of Medicine, University of California, San Francisco

Contact

  • gfields@scripps.edu

Websites

  • Gregg Fields, Ph.D.
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Publications

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  • academic article

    • Khamoui, A. V., Tokmina-Roszyk, D., Rossiter, H. B., Fields, G. B., Visavadiya, N. P. Hepatic proteome analysis reveals altered mitochondrial metabolism and suppressed acyl-CoA synthetase-1 in colon-26 tumor-induced cachexia Physiological Genomics  2020 52:203-216  DOI:10.1152/physiolgenomics.00124.2019  PMID:32146873
    • FitzGerald, F. G., Benavente, M. R. C., Garcia, C., Rivero, Y., Singh, Y., Wang, H. J., Fields, G. B., Cudic, M. TF-containing MUC1 glycopeptides fail to entice Galectin-1 recognition of tumor-associated Thomsen-Freidenreich (TF) antigen (CD176) in solution Glycoconjugate Journal  2020  DOI:10.1007/s10719-020-09951-x  PMID:33001366
    • Knapinska, A. M., Hart, M., Drotleff, G., Fields, G. B. Matrix metalloproteinase triple-helical peptide inhibitors: potential cross-reactivity with caspase-11 Molecules  2019 24  DOI:10.3390/molecules24234355  PMID:31795279  PMCID:PMC6930605
    • Fields, G. B. The rebirth of matrix metalloproteinase inhibitors: moving beyond the dogma Cells  2019 8  DOI:10.3390/cells8090984  PMID:31461880
    • Pahwa, S., Bhowmick, M., Amar, S., Cao, J., Strongin, A. Y., Fridman, R., Weiss, S. J., Fields, G. B. Characterization and regulation of MT1-MMP cell surface-associated activity Chemical Biology & Drug Design  2019 93:1251-1264  DOI:10.1111/cbdd.13450  PMID:30480376  PMCID:PMC6536371
    • Marcink, T. C., Simoncic, J. A., An, B., Knapinska, A. M., Fulcher, Y. G., Akkaladevi, N., Fields, G. B., Van Doren, S. R. MT1-MMP binds membranes by opposite tips of its β propeller to position it for pericellular proteolysis Structure  2019 27:281-292  DOI:10.1016/j.str.2018.10.008  PMID:30471921  PMCID:PMC6365218
    • Tokmina-Roszyk, M., Fields, G. B. Dissecting MMP P-10 and P-11 subsite sequence preferences, utilizing a positional scanning, combinatorial triple-helical peptide library Journal of Biological Chemistry  2018 293:16661-16676  DOI:10.1074/jbc.RA118.003266  PMID:30185620  PMCID:PMC6204916
    • Fuerst, R., Yong Choi, J., Knapinska, A. M., Smith, L., Cameron, M. D., Ruiz, C., Fields, G. B., Roush, W. R. Development of matrix metalloproteinase-13 inhibitors - A structureactivity/structure-property relationship study Bioorganic & Medicinal Chemistry  2018 26:4984-4995  DOI:10.1016/j.bmc.2018.08.020  PMID:30249495
    • Karabencheva-Christova, T. G., Christov, C. Z., Fields, G. B. Conformational dynamics of matrix metalloproteinase-1.triple-helical peptide complexes Journal of Physical Chemistry B  2018 122:5316-5326  DOI:10.1021/acs.jpcb.7b09771  PMID:29161042
    • Stawikowski, M. J., Fields, G. B. Tricine as a convenient scaffold for the synthesis of C-terminally branched collagen-model peptides Tetrahedron Letters  2018 59:130-134  DOI:10.1016/j.tetlet.2017.12.008
    • Amar, S., Smith, L., Fields, G. B. Matrix metalloproteinase collagenolysis in health and disease Biochimica Et Biophysica Acta-Molecular Cell Research  2017 1864:1940-1951  DOI:10.1016/bbamcr.2017.04.015  PMID:28456643  PMCID:PMC5605394
    • Choi, J. Y., Fuerst, R., Knapinska, A. M., Taylor, A. B., Smith, L., Cao, X., Hart, P. J., Fields, G. B., Roush, W. R. Structure-based design and synthesis of potent and selective matrix metalloproteinase 13 inhibitors Journal of Medicinal Chemistry  2017 60:5816-5825  DOI:10.1021/acs.jmedchem.7b00514  PMID:28653849
    • Knapinska, A. M., Estrada, C. A., Fields, G. B. The roles of matrix metalloproteinases in pancreatic cancer Progress in Molecular Biology and Translational Science  2017 148:339-354  DOI:10.1016/bs.pmbts.2017.03.004  PMID:28662827
    • Singh, W., Fields, G. B., Christov, C. Z., Karabencheva-Christova, T. G. Effects of mutations on structure-function relationships of matrix metalloproteinase-1 International Journal of Molecular Sciences  2016 17  DOI:10.3390/ijms17101727  PMID:27754420  PMCID:PMC5085758
    • Madoux, F., Tredup, C., Scampavia, L., Chase, P. S., Hodder, P. S., Fields, G. B., Becker-Pauly, C., Minond, D., Spicer, T. P. Development of high throughput screening assays and pilot screen for inhibitors of metalloproteases meprin α and β Biopolymers  2014 102:396-406  DOI:10.1002/bip.22527  PMID:25048711  PMCID:PMC4339026
    • Jiang, J., Taylor, A. B., Choi, J. Y., Hart, P. J., Roush, W. R., Fields, G. B., Hodder, P. S., Minong, D., Spicer, T. P. Characterization of selective exosite-binding inhibitors of matrix metalloproteinase 13 that prevent articular cartilage degradation in vitro Journal of Medicinal Chemistry  2014 57:9598-9611  DOI:10.1021/jm501284e  PMID:25330343  PMCID:PMC4255739
    • Roth, J., Minond, D., Darout, E., Liu, Q., Lauer, J., Hodder, P., Fields, G. B., Roush, W. R. Identification of novel, exosite-binding matrix metalloproteinase-13 inhibitor scaffolds Bioorganic & Medicinal Chemistry Letters  2011 21:7180-7184  DOI:10.1016/j.bmcl.2011.09.077  PMID:22018790  PMCID:PMC3210410
    • Lauer-Fields, J. L., Chalmers, M. J., Busby, S. A., Minond, D., Griffin, P. R., Fields, G. B. Identification of specific hemopexin-like domain residues that facilitate matrix metalloproteinase collagenolytic activity Journal of Biological Chemistry  2009 284:24017-24024  DOI:10.1074/jbc.M109.016873  PMID:19574232  PMCID:PMC2781996
    • Lauer-Fields, J. L., Minond, D., Chase, P. S., Baillargeon, P. E., Saldanha, S. A., Stawikowska, R., Hodder, P., Fields, G. B. High throughput screening of potentially selective mmp-13 exosite inhibitors utilizing a triple-helical fret substrate Bioorganic & Medicinal Chemistry  2009 17:990-1005  DOI:10.1016/j.bmc.2008.03.004  PMID:18358729  PMCID:PMC3298815
    • Lauer-Fields, J. L., Spicer, T. P., Chase, P. S., Cudic, M., Burstein, G. D., Nagase, H., Hodder, P., Fields, G. B. Screening of potential a, disintegrin and metalloproteinase with thrombospondin motifs-4 inhibitors using a collagen model fluorescence resonance energy transfer substrate Analytical Biochemistry  2008 373:43-51  DOI:10.1016/j.ab.2007.09.014  PMID:17949675  PMCID:PMC2245870
  • chapter

    • Tagged Karabencheva-Christova, T. G., Christov, C. Z., Fields, G. B. Collagenolytic matrix metalloproteinase structure-function relationships: insights from molecular dynamics studies Structural and Mechanistic Enzymology. 1-24. 2017  DOI:10.1016/bs.apcsb.2017.04.001
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Background

education and training

  • Ph.D. in Chemistry, The Florida State University 1982 - 1988
  • B.S. in Chemistry, University of Florida 1979 - 1982
  • A.A. in Chemistry, Broward Community College 1976 - 1979
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Contact

full name

  • Gregg B. Fields

geographic location

  • Scripps Florida 

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