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Encalada, Sandra
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Encalada, Sandra

Faculty Member
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Positions

  • 2017 - Assistant Professor (Joint Appointment), Neuroscience , Scripps Research
  • 2017 - Arlene and Arnold Goldstein Assistant Professor, Molecular Medicine , Scripps Research
  • 2011 - Faculty Member, Skaggs Graduate School of Chemical and Biological Sciences , Scripps Research
  • 2011 - Assistant Professor (Joint Appointment), Dorris Neuroscience Center , Scripps Research
  • 2013 - 2017 Assistant Professor (Joint Appointment), Cell and Molecular Biology (CMB) , Scripps Research
  • 2013 - 2017 Assistant Professor (Joint Appointment), Molecular and Cellular Neuroscience (MCN) , Scripps Research
  • 2011 - 2017 Arlene and Arnold Goldstein Assistant Professor, Molecular and Experimental Medicine (MEM) , Scripps Research
  • 2011 - 2012 Assistant Professor (Joint Appointment), Cell Biology , Scripps Research
Dr. Encalada studies the mechanisms of intracellular transport in neurons using a combination of cell biology, genetics, high-resolution light and electron microscopy, and small and single-molecule approaches in mammalian neurons and Caenorhabditis elegans, to identify and characterize molecular motor regulatory mechanisms. They are also focused on how defective intracellular transport in axons leads to neurodegeneration in models of Alzheimer’s Disease, Amyotrophic Lateral Sclerosis (ALS), prion diseases, and transthyretin amyloidoses.

Research Areas research areas

  • Alzheimer (UMLS)

Contact

  • encalada@scripps.edu

Websites

  • Sandra Encalada, Ph.D.
  • Laboratory Website
  • Publications
  • Research
  • Teaching
  • Background
  • Contact
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Publications

recent publications
  • All Publications
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  • Publications without PubMed PMIDs

  • academic article

    • Nieto-Torres, J. L., Encalada, S. E., Hansen, M. LC3B phosphorylation: autophagosome's ticket for a ride toward the cell nucleus Autophagy  2021 17:3266-3268  DOI:10.1080/15548627.2021.1961073  PMID:34424150  PMCID:PMC8526023
    • Race, B., Williams, K., Baune, C., Striebel, J. F., Winkler, C. W., Carroll, J. A., Encalada, S. E., Chesebro, B. Deletion of Kif5c Does Not Alter Prion Disease Tempo or Spread in Mouse Brain Viruses-Basel  2021 13  DOI:10.3390/v13071391  PMID:34372599  PMCID:PMC8310152
    • Nieto-Torres, J. L., Shanahan, S. L., Chassefeyre, R., Chaiamarit, T., Zaretski, S., Landeras-Bueno, S., Verhelle, A., Encalada, S. E., Hansen, M. LC3B phosphorylation regulates FYCO1 binding and directional transport of autophagosomes Current Biology  2021 31:3440-3449  DOI:10.1016/j.cub.2021.05.052  PMID:34146484  PMCID:PMC8439105
    • Chassefeyre, R., Chaiamarit, T., Verhelle, A., Novak, S. W., Andrade, L. R., Leitao, A. D. G., Manor, U., Encalada, S. E. Endosomal sorting drives the formation of axonal prion protein endoggresomes Science Advances  2021 7  DOI:10.1126/sciadv.abg3693  PMID:34936461  PMCID:PMC8694590
    • Butler, V. J., Salazar, D. A., Soriano-Castell, D., Alves-Ferreira, M., Dennissen, F. J. A., Vohra, M., Oses-Prieto, J. A., Li, K. H., Wang, A. L., Jing, B., Li, B., Groisman, A., et al. Tau/MAPT disease-associated variant A152T alters tau function and toxicity via impaired retrograde axonal transport Human Molecular Genetics  2019 28:1498-1514  DOI:10.1093/hmg/ddy442  PMID:30590647  PMCID:PMC6489414
    • Madhivanan, K., Greiner, E. R., Alves-Ferreira, M., Soriano-Castell, D., Rouzbeh, N., Aguirre, C. A., Paulsson, J. F., Chapman, J., Jiang, X., Ooi, F. K., Lemos, C., Dillin, A., et al. Cellular clearance of circulating transthyretin decreases cell-nonautonomous proteotoxicity in Caenorhabditis elegans Proc Natl Acad Sci U S A  2018 115:E7710-E7719  DOI:10.1073/pnas.1801117115  PMID:30061394  PMCID:PMC6099907
    • Neumann, S., Chassefeyre, R., Campbell, G. E., Encalada, S. E. KymoAnalyzer: a software tool for the quantitative analysis of intracellular transport in neurons Traffic  2017 18:71-88  DOI:10.1111/tra.12456  PMID:27770501
    • Rangaraju, S., Solis, G. M., Thompson, R. C., Gomez-Amaro, R. L., Kurian, L., Encalada, S. E., Niculescu, A. B., Salomon, D. R., Petrascheck, M. Suppression of transcriptional drift extends C-elegans lifespan by postponing the onset of mortality Elife  2015 4:e08833  DOI:10.7554/eLife.08833  PMID:26623667  PMCID:PMC4720515
    • Eisele, Y. S., Monteiro, C., Fearns, C., Encalada, S. E., Wiseman, R. L., Powers, E. T., Kelly, J. W. Targeting protein aggregation for the treatment of degenerative diseases Nature Reviews Drug Discovery  2015 14:759-780  DOI:10.1038/nrd4593  PMID:26338154  PMCID:PMC4628595
    • Baranczak, A., Liu, Y., Connelly, S., Du, W. G. H., Greiner, E. R., Genereux, J. C., Wiseman, R. L., Eisele, Y. S., Bradbury, N. C., Dong, J., Noodleman, L., Sharpless, K. B., et al. A fluorogenic aryl fluorosulfate for intraorganellar transthyretin imaging in living cells and in Caenorhabditis elegans Journal of the American Chemical Society  2015 137:7404-7414  DOI:10.1021/jacs.5b03042  PMID:26051248  PMCID:PMC4472559
    • Neumann, S.*, Campbell, G. E.*, Szpankowski, L., Goldstein, L. S. B., Encalada, S. E. Characterizing the composition of molecular motors on moving axonal cargo using "cargo mapping" analysis Journal of Visualized Experiments : JoVE  2014  DOI:10.3791/52029  PMID:25406537  PMCID:PMC4353387 (* = equal contribution)
    • Encalada, S. E., Goldstein, L. S. Biophysical challenges to axonal transport: motor-cargo deficiencies and neurodegeneration Annual Review of Biophysics  2014 43:141-169  DOI:10.1146/annurev-biophys-051013-022746  PMID:24702007
    • Szpankowski, L., Encalada, S. E., Goldstein, L. S. B. Subpixel colocalization reveals amyloid precursor protein-dependent kinesin-1 and dynein association with axonal vesicles Proceedings of the National Academy of Sciences of the United States of America  2012 109:8582-8587  DOI:10.1073/pnas.1120510109  PMID:22582169  PMCID:PMC3365224
    • Encalada, S. E., Szpankowski, L., Xia, C. H., Goldstein, L. S. B. Stable kinesin and dynein assemblies drive the axonal transport of mammalian prion protein vesicles Cell  2011 144:551-565  DOI:10.1016/j.cell.2011.01.021  PMID:21335237  PMCID:PMC3576050
    • Encalada, S. E., Moya, K. L., Lehmann, S., Zahn, R. The role of the prion protein in the molecular basis for synaptic plasticity and nervous system development Journal of Molecular Neuroscience  2008 34:9-15  DOI:10.1007/s12031-007-0011-x  PMID:18157653
    • Encalada, S. E., Willis, J., Lyczak, R., Bowerman, B. A spindle checkpoint functions during mitosis in the early Caenorhabditis elegans embryo Molecular Biology of the Cell  2005 16:1056-1070  DOI:10.1091/mbc.E04-08-0712  PMID:15616189  PMCID:PMC551473
    • Gomes, J. E., Encalada, S. E., Swan, K. A., Shelton, C. A., Carter, J. C., Bowerman, B. The maternal gene spn-4 encodes a predicted RRM protein required for mitotic spindle orientation and cell fate patterning in early C. elegans embryos Development  2001 128:4301-4314  PMID:11684665
    • Encalada, S. E., Martin, P. R., Phillips, J. B., Lyczak, R., Hamill, D. R., Swan, K. A., Bowerman, B. DNA replication defects delay cell division and disrupt cell polarity in early Caenorhabditis elegans embryos Developmental Biology  2000 228:225-238  DOI:10.1006/dbio.2000.9965  PMID:11112326
    • Fernando, P., Pfrender, M. E., Encalada, S. E., Lande, R. Mitochondrial DNA variation, phylogeography and population structure of the Asian elephant Heredity  2000 84:362-372  DOI:10.1038/sj/hdy/6886740  PMID:10762406
    • Encalada, S. E., Bjorndal, K. A., Bolten, A. B., Zurita, J. C., Schroeder, B., Possardt, E., Sears, C. J., Bowen, B. W. Population structure of loggerhead turtle (Caretta caretta) nesting colonies in the Atlantic and Mediterranean as inferred from mitochondrial DNA control region sequences Marine Biology  1998 130:567-575  DOI:10.1007/s002270050278
    • Lahanas, P. N., Bjorndal, K. A., Bolten, A. B., Encalada, S. E., Miyamoto, M. M., Valverde, R. A., Bowen, B. W. Genetic composition of a green turtle (Chelonia mydas) feeding ground population: evidence for multiple origins Marine Biology  1998 130:345-352  DOI:10.1007/s002270050254
    • Bolten, A. B., Bjorndal, K. A., Martins, H. R., Dellinger, T., Biscoito, M. J., Encalada, S. E., Bowen, B. W. Transatlantic developmental migrations of loggerhead sea turtles demonstrated by mtDNA sequence analysis Ecological Applications  1998 8:1-7  DOI:10.1890/1051-0761(1998)008[0001:TDMOLS]2.0.CO;2
    • Encalada, S. E., Lahanas, P. N., Bjorndal, K. A., Bolten, A. B., Miyamoto, M. M., Bowen, B. W. Phylogeography and population structure of the Atlantic and Mediterranean green turtle Chelonia mydas: a mitochondrial DNA control region sequence assessment Molecular Ecology  1996 5:473-483  DOI:10.1111/j.1365-294X.1996.tb00340.x  PMID:8794558
  • thesis

    • Regulation of cell cycle timing in the early Caenorhabditis elegans embryo 2003
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Research

research overview

  • Intracellular Transport and Neurodegeneration

    Our lab is interested in characterizing the interactions between molecular motors and their vesicular cargo to regulate axonal transport in neurons.  We use a combination of cell biology, genetics, biochemistry, and high-resolution microscopy in mammalian neurons and in the soil nematode Caenorhabditis elegans, to identify and characterize motor-cargo regulatory complexes. We also seek to integrate and extend our knowledge of motor regulation to dissect the role that defective vesicular transport plays in the accumulation of misfolded proteins inside axons, and scrutinize the hypothesis that this contributes to or causes neurodegeneration.  We use mammalian and C. elegans systems to build models of protein aggregation diseases including prion diseases, Alzheimer’s disease, and transthyretin amyloidosis-related diseases, to characterize the role of motor-based transport in toxicity and infectivity.

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Teaching

advisees

  • graduate advising relationship

    • Chaiamarit, Tai, Ph.D.  candidate, 2018 -
    • Wu, Yin, Ph.D.  candidate, 2019 -
    • Smith, Alyson Sarah (Cook), Ph.D.  candidate, 2014 - 2018
    • Encalada, Sandra advising Grotjahn, Danielle 2014 - 2017
    • Campbell, George E, Ph.D.  candidate, 2012 - 2017
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Background

education and training

  • Ph.D. in Molecular Genetics, University of Oregon , Institute of Molecular Biology 2003
  • M.S. in Population Genetics, University of Florida 1995
  • B.A. in Physics, Earlham College 1992
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Contact

full name

  • Sandra Encalada

geographic location

  • Scripps California 

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