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Edwards, Jacob

Graduate Student

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Publications

recent publications

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  • Widen, J. C., Kempema, A. M., Baur, J. W., Skopec, H. M., Edwards, J. T., Brown, T. J., Brown, D. A., Meece, F. A., Harki, D. A. Helenalin analogues targeting NF-κB p65: thiol reactivity and cellular potency studies of varied electrophiles Chemmedchem  2018 13:303-311  DOI:10.1002/cmdc.201700752  PMID:29349898  PMCID:PMC5894512
  • Merchant, R. R., Edwards, J. T., Qin, T., Kruszyk, M. M., Bi, C., Che, G., Bao, D. H., Qiao, W., Sun, L., Collins, M. R., Fadeyi, O. O., Gallego, G. M., et al. Modular radical cross-coupling with sulfones enables access to sp(3)-rich (fluoro)alkylated scaffolds Science  2018 360:75-80  DOI:10.1126/science.aar7335  PMID:29456201
  • Edwards, J. T., Merchant, R. R., McClymont, K. S., Knouse, K. W., Qin, T., Malins, L. R., Vokits, B., Shaw, S. A., Bao, D. H., Wei, F. L., Zhou, T., Eastgate, M. D., et al. Decarboxylative alkenylation Nature  2017 545:213-218  DOI:10.1038/nature22307  PMID:28424520
  • Smith, J. M., Qin, T., Merchant, R. R., Edwards, J. T., Malins, L. R., Liu, Z., Che, G., Shen, Z., Shaw, S. A., Eastgate, M. D., Baran, P. S. Decarboxylative alkynylation Angewandte Chemie-International Edition  2017 56:11906-11910  DOI:10.1002/anie.201705107  PMID:28636185  PMCID:PMC5792189
  • Lo, J. C., Kim, D., Pan, C. M., Edwards, J. T., Yabe, Y., Gui, J. H., Qin, T., Gutierrez, S., Giacoboni, J., Smith, M. W., Holland, P. L., Baran, P. S. Fe-catalyzed C-C bond construction from olefins via radicals Journal of the American Chemical Society  2017 139:2484-2503  DOI:10.1021/jacs.6b13155  PMID:28094980  PMCID:PMC5314431
  • Qin, T., Malins, L. R., Edwards, J. T., Merchant, R. R., Novak, A. J. E., Zhong, J. Z., Mills, R. B., Yan, M., Yuan, C., Eastgate, M. D., Baran, P. S. Nickel-catalyzed barton decarboxylation and giese reactions: a practical take on classic transforms Angewandte Chemie-International Edition  2017 56:260-265  DOI:10.1002/anie.201609662  PMID:27981703  PMCID:PMC5295468
  • Qin, T., Cornella, J., Li, C., Malins, L. R., Edwards, J. T., Kawamura, S., Maxwell, B. D., Eastgate, M. D., Baran, P. S. A general alkyl-alkyl cross-coupling enabled by redox-active esters and alkylzinc reagents Science  2016 352:801-805  DOI:10.1126/science.aaf6123  PMID:27103669  PMCID:PMC4867118
  • Wang, J., Qin, T., Chen, T. G., Wimmer, L., Edwards, J. T., Cornella, J., Vokits, B., Shaw, S. A., Baran, P. S. Nickel-catalyzed cross-coupling of redox-active esters with boronic acids Angewandte Chemie-International Edition  2016 55:9675-9678  DOI:10.1002/anie.201605463  PMID:27380912  PMCID:PMC5232357
  • Cornella, J., Edwards, J. T., Qin, T., Kawamura, S., Wang, J., Pan, C. M., Gianatassio, R., Schmidt, M., Eastgate, M. D., Baran, P. S. Practical Ni-catalyzed aryl-alkyl cross-coupling of secondary redox-active esters Journal of the American Chemical Society  2016 138:2174-2177  DOI:10.1021/jacs.6b00250  PMID:26835704  PMCID:PMC4768290
  • Yan, M., Lo, J. C., Edwards, J. T., Baran, P. S. Radicals: reactive intermediates with translational potential Journal of the American Chemical Society  2016 138:12692-12714  DOI:10.1021/jacs.6b08856  PMID:27631602  PMCID:PMC5054485

Background

education and training

• Ph.D. in Chemistry, Scripps Research 2014 -
• B.S. in Chemistry, Mathematics, University of Minnesota 2010 - 2014

advisee of

• graduate advising relationship

  • Baran, Phil, Ph.D.  candidacy, 2015 -

Contact

full name

• Jacob T Edwards

geographic location

• Scripps California