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Duncan, Katharine
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Duncan, Katharine

Graduate Student
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Positions

  • 2018 - Scientific Program Manager, Kelly Services
  • 2018 Senior Scientist, Abide Therapeutics
  • 2014 - 2017 Scientist, Abide Therapeutics

Websites

  • Doctoral Dissertation
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Publications

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  • academic article

    • degree-related publication Lukesh III, J. C., Carney, D. W., Dong, H. J., Cross, R. M., Shukla, V., Duncan, K. K., Yang, S. L., Brody, D. M., Brutsch, M. M., Radakovic, A., Boger, D. L. Vinblastine 20 ' amides: synthetic analogues that maintain or improve potency and simultaneously overcome Pgp-derived efflux and resistance Journal of Medicinal Chemistry  2017 60:7591-7604  DOI:10.1021/acs.jmedchem.7b00958  PMID:28857558  PMCID:PMC5599373
    • degree-related publication Duncan, K. K., Otrubova, K., Boger, D. L. alpha-Ketoheterocycle inhibitors of fatty acid amide hydrolase: exploration of conformational constraints in the acyl side chain Bioorganic & Medicinal Chemistry  2014 22:2763-2770  DOI:10.1016/j.bmc.2014.03.013  PMID:24690529  PMCID:PMC4029506
    • degree-related publication Campbell, E. L., Skepper, C. K., Sankar, K., Duncan, K. K., Boger, D. L. Transannular Diels-Alder/1,3-dipolar cycloaddition cascade of 1,3,4-oxadiazoles: total synthesis of a unique set of vinblastine analogues Organic Letters  2013 15:5306-5309  DOI:10.1021/oI402549n  PMID:24087969
    • degree-related publication Barker, T. J., Duncan, K. K., Otrubova, K., Boger, D. L. Potent vinblastine C20' ureas displaying additionally improved activity against a vinblastine-resistant cancer cell line ACS Medicinal Chemistry Letters  2013 4:985-988  DOI:10.1021/ml400281w  PMID:24223237  PMCID:PMC3821838
    • degree-related publication Wolfe, A. L., Duncan, K. K., Lajiness, J. P., Zhu, K. C., Duerfeldt, A. S., Boger, D. L. A fundamental relationship between hydrophobic properties and biological activity for the duocarmycin class of DNA-alkylating antitumor drugs: hydrophobic-binding-driven bonding Journal of Medicinal Chemistry  2013 56:6845-6857  DOI:10.1021/jm400665c  PMID:23944748  PMCID:PMC3793852
    • degree-related publication Wolfe, A. L., Duncan, K. K., Parelkar, N. K., Brown, D., Vielhauer, G. A., Boger, D. L. Efficacious cyclic N-acyl O-amino phenol duocarmycin prodrugs Journal of Medicinal Chemistry  2013 56:4104-4115  DOI:10.1021/jm400413r  PMID:23627265  PMCID:PMC3687800
    • degree-related publication Leggans, E. K., Duncan, K. K., Barker, T. J., Schleicher, K. D., Boger, D. L. A remarkable series of vinblastine analogues displaying enhanced activity and an unprecedented tubulin binding steric tolerance: C20' urea derivatives Journal of Medicinal Chemistry  2013 56:628-639  DOI:10.1021/jm3015684  PMID:23244701  PMCID:PMC3574233
    • degree-related publication Schleicher, K. D., Sasaki, Y., Tam, A., Kato, D., Duncan, K. K., Boger, D. L. Total synthesis and evaluation of vinblastine analogues containing systematic deep-seated modifications in the vindoline subunit ring system: Core redesign Journal of Medicinal Chemistry  2013 56:483-495  DOI:10.1021/jm3014376  PMID:23252481  PMCID:PMC3554876
    • degree-related publication Wolfe, A. L., Duncan, K. K., Parelkar, N. K., Weir, S. J., Vielhauer, G. A., Boger, D. L. A novel, unusually efficacious duocarmycin carbamate prodrug that releases no residual byproduct Journal of Medicinal Chemistry  2012 55:5878-5886  DOI:10.1021/jm300330b  PMID:22650244  PMCID:PMC3386426
    • degree-related publication Leggans, E. K., Barker, T. J., Duncan, K. K., Boger, D. L. Iron(III)/NaBH4-mediated additions to unactivated alkenes: synthesis of novel 20'-vinblastine analogues Organic Letters  2012 14:1428-1431  DOI:10.1021/ol300173v  PMID:22369097  PMCID:PMC3306530
    • degree-related publication Gotoh, H., Duncan, K. K., Robertson, W. M., Boger, D. L. 10 '-fluorovinblastine and 10 '-fluorovincristine: synthesis of a key series of modified vinca alkaloids ACS Medicinal Chemistry Letters  2011 2:948-952  DOI:10.1021/ml200236a  PMID:22247789  PMCID:PMC3254105
    • Beguin, C., Duncan, K. K., Munro, T. A., Ho, D. M., Xu, W., Liu-Chen, L. Y., Carlezon Jr., W. A., Cohen, B. M. Modification of the furan ring of salvinorin A: identification of a selective partial agonist at the kappa opioid receptor Bioorganic & Medicinal Chemistry  2009 17:1370-1380  DOI:10.1016/j.bmc.2008.12.012  PMID:19147366  PMCID:PMC2680211
    • Munro, T. A., Duncan, K. K., Xu, W., Wang, Y., Liu-Chen, L. Y., Carlezon Jr., W. A., Cohen, B. M., Beguin, C. Standard protecting groups create potent and selective kappa opioids: salvinorin B alkoxymethyl ethers Bioorganic & Medicinal Chemistry  2008 16:1279-1286  DOI:10.1016/j.bmc.2007.10.067  PMID:17981041  PMCID:PMC2568987
    • Munro, T. A., Duncan, K. K., Staples, R. J., Xu, W., Liu-Chen, L. Y., Beguin, C., Carlezon Jr., W. A., Cohen, B. M. 8-epi-Salvinorin B: crystal structure and affinity at the kappa opioid receptor Beilstein Journal of Organic Chemistry  2007 3  DOI:10.1186/1860-5397-3-1  PMID:17212822  PMCID:PMC1805503
    • Taye, A., Chen, H., Duncan, K., Zhang, Z., Hendrix, L., Gonzalez, J., Ching, W. Production of recombinant protein Pap31 and its application for the diagnosis of Bartonella bacilliformis infection Annals of the New York Academy of Sciences  2005 1063:280-285  DOI:10.1196/annals.1355.045  PMID:16481528
    • Leung, H. O., Cashion, W. T., Duncan, K. K., Hagan, C. L., Joo, S. Nuclear quadrupole hyperfine structure in the microwave spectrum of HCl-N2O: Electric field gradient perturbation of N2O by HCl Journal of Chemical Physics  2004 121:237-247  DOI:10.1063/1.1756871  PMID:15260541
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Background

education and training

  • Ph.D. in Chemistry, Scripps Research 2008 - 2014
  • B.A. in Chemistry, Amherst College 2002 - 2006

advisee of

  • graduate advising relationship

    • Boger, Dale, Ph.D.  candidacy, 2009 - 2014
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Contact

full name

  • Katharine Keith Duncan

geographic location

  • Scripps California 

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