Duncan, Katharine

Graduate Student

Positions

Senior Scientist, Abide Therapeutics 2018 -
Scientist, Abide Therapeutics 2014 - 2017

Websites

Doctoral Dissertation

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academic article
- Lukesh III, J. C., Carney, D. W., Dong, H. J., Cross, R. M., Shukla, V., Duncan, K. K., Yang, S. L., Brody, D. M., Brutsch, M. M., Radakovic, A., Boger, D. L. Vinblastine 20 ' amides: synthetic analogues that maintain or improve potency and simultaneously overcome Pgp-derived efflux and resistance Journal of Medicinal Chemistry 2017 60:7591-7604 DOI:10.1021/acs.jmedchem.7b00958 PMID:28857558 PMCID:PMC5599373
- Duncan, K. K., Otrubova, K., Boger, D. L. alpha-Ketoheterocycle inhibitors of fatty acid amide hydrolase: exploration of conformational constraints in the acyl side chain Bioorganic & Medicinal Chemistry 2014 22:2763-2770 DOI:10.1016/j.bmc.2014.03.013 PMID:24690529 PMCID:PMC4029506
- Wolfe, A. L., Duncan, K. K., Lajiness, J. P., Zhu, K. C., Duerfeldt, A. S., Boger, D. L. A fundamental relationship between hydrophobic properties and biological activity for the duocarmycin class of DNA-alkylating antitumor drugs: hydrophobic-binding-driven bonding Journal of Medicinal Chemistry 2013 56:6845-6857 DOI:10.1021/jm400665c PMID:23944748 PMCID:PMC3793852
- Leggans, E. K., Duncan, K. K., Barker, T. J., Schleicher, K. D., Boger, D. L. A remarkable series of vinblastine analogues displaying enhanced activity and an unprecedented tubulin binding steric tolerance: C20' urea derivatives Journal of Medicinal Chemistry 2013 56:628-639 DOI:10.1021/jm3015684 PMID:23244701 PMCID:PMC3574233
- Wolfe, A. L., Duncan, K. K., Parelkar, N. K., Brown, D., Vielhauer, G. A., Boger, D. L. Efficacious cyclic N-acyl O-amino phenol duocarmycin prodrugs Journal of Medicinal Chemistry 2013 56:4104-4115 DOI:10.1021/jm400413r PMID:23627265 PMCID:PMC3687800
- Barker, T. J., Duncan, K. K., Otrubova, K., Boger, D. L. Potent vinblastine C20' ureas displaying additionally improved activity against a vinblastine-resistant cancer cell line ACS Medicinal Chemistry Letters 2013 4:985-988 DOI:10.1021/ml400281w PMID:24223237 PMCID:PMC3821838
- Schleicher, K. D., Sasaki, Y., Tam, A., Kato, D., Duncan, K. K., Boger, D. L. Total synthesis and evaluation of vinblastine analogues containing systematic deep-seated modifications in the vindoline subunit ring system: Core redesign Journal of Medicinal Chemistry 2013 56:483-495 DOI:10.1021/jm3014376 PMID:23252481 PMCID:PMC3554876
- Campbell, E. L., Skepper, C. K., Sankar, K., Duncan, K. K., Boger, D. L. Transannular Diels-Alder/1,3-dipolar cycloaddition cascade of 1,3,4-oxadiazoles: total synthesis of a unique set of vinblastine analogues Organic Letters 2013 15:5306-5309 DOI:10.1021/oI402549n PMID:24087969
- Wolfe, A. L., Duncan, K. K., Parelkar, N. K., Weir, S. J., Vielhauer, G. A., Boger, D. L. A novel, unusually efficacious duocarmycin carbamate prodrug that releases no residual byproduct Journal of Medicinal Chemistry 2012 55:5878-5886 DOI:10.1021/jm300330b PMID:22650244 PMCID:PMC3386426
- Leggans, E. K., Barker, T. J., Duncan, K. K., Boger, D. L. Iron(III)/NaBH4-mediated additions to unactivated alkenes: synthesis of novel 20'-vinblastine analogues Organic Letters 2012 14:1428-1431 DOI:10.1021/ol300173v PMID:22369097 PMCID:PMC3306530
- Gotoh, H., Duncan, K. K., Robertson, W. M., Boger, D. L. 10 '-fluorovinblastine and 10 '-fluorovincristine: synthesis of a key series of modified vinca alkaloids ACS Medicinal Chemistry Letters 2011 2:948-952 DOI:10.1021/ml200236a PMID:22247789 PMCID:PMC3254105
- Beguin, C., Duncan, K. K., Munro, T. A., Ho, D. M., Xu, W., Liu-Chen, L. Y., Carlezon Jr., W. A., Cohen, B. M. Modification of the furan ring of salvinorin A: identification of a selective partial agonist at the kappa opioid receptor Bioorganic & Medicinal Chemistry 2009 17:1370-1380 DOI:10.1016/j.bmc.2008.12.012 PMID:19147366 PMCID:PMC2680211
- Munro, T. A., Duncan, K. K., Xu, W., Wang, Y., Liu-Chen, L. Y., Carlezon Jr., W. A., Cohen, B. M., Beguin, C. Standard protecting groups create potent and selective kappa opioids: salvinorin B alkoxymethyl ethers Bioorganic & Medicinal Chemistry 2008 16:1279-1286 DOI:10.1016/j.bmc.2007.10.067 PMID:17981041 PMCID:PMC2568987
- Munro, T. A., Duncan, K. K., Staples, R. J., Xu, W., Liu-Chen, L. Y., Beguin, C., Carlezon Jr., W. A., Cohen, B. M. 8-epi-Salvinorin B: crystal structure and affinity at the kappa opioid receptor Beilstein Journal of Organic Chemistry 2007 3 DOI:10.1186/1860-5397-3-1 PMID:17212822 PMCID:PMC1805503
- Taye, A., Chen, H., Duncan, K., Zhang, Z., Hendrix, L., Gonzalez, J., Ching, W. Production of recombinant protein Pap31 and its application for the diagnosis of Bartonella bacilliformis infection Annals of the New York Academy of Sciences 2005 1063:280-285 DOI:10.1196/annals.1355.045 PMID:16481528
- Leung, H. O., Cashion, W. T., Duncan, K. K., Hagan, C. L., Joo, S. Nuclear quadrupole hyperfine structure in the microwave spectrum of HCl-N2O: Electric field gradient perturbation of N2O by HCl Journal of Chemical Physics 2004 121:237-247 DOI:10.1063/1.1756871 PMID:15260541