recent publications
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academic article
- Quereda, V., Bayle, S., Vena, F., Frydman, S. M., Monastyrskyi, A., Roush, W. R., Duckett, D. R. Therapeutic targeting of CDK12/CDK13 in triple-negative breast cancer Cancer Cell 2019 36:545-558 DOI:10.1016/j.ccell.2019.09.004 PMID:31668947
- Crawley, O., Opperman, K. J., Desbois, M., Adrados, I., Borgen, M. A., Giles, A. C., Duckett, D. R., Grill, B. Autophagy is inhibited by ubiquitin ligase activity in the nervous system Nature Communications 2019 10 DOI:10.1038/s41467-019-12804-3 PMID:31676756 PMCID:PMC6825199
- Quereda, V., Hou, S., Madoux, F., Scampavia, L., Spicer, T. P., Duckett, D. A cytotoxic three-dimensional-spheroid, high-throughput assay using patient-derived glioma stem cells SLAS Discovery 2018 23:842-849 DOI:10.1177/2472555218775055 PMID:29750582 PMCID:PMC6102052
- Monastyrskyi, A., Nilchan, N., Quereda, V., Noguchi, Y., Ruiz, C., Grant, W., Cameron, M., Duckett, D., Roush, W. Development of dual casein kinase 1δ/1ε (CK1δ/ε) inhibitors for treatment of breast cancer Bioorganic & Medicinal Chemistry 2018 26:590-602 DOI:10.1016/j.bmc.2017.12.020 PMID:29289448 PMCID:PMC5803353
- Monastyrskyi, A., Bayle, S., Quereda, V., Grant, W., Cameron, M., Duckett, D., Roush, W. Discovery of 2-arylquinazoline derivatives as a new class of ASK1 inhibitors Bioorganic & Medicinal Chemistry Letters 2018 28:400-404 DOI:10.1016/j.bmcl.2017.12.026 PMID:29277458
- Wood, S. D., Grant, W., Adrados, I., Choi, J. Y., Alburger, J. M., Duckett, D. R., Roush, W. R. In silica HTS and structure based optimization of indazole-derived ULK1 inhibitors ACS Medicinal Chemistry Letters 2017 8:1258-1263 DOI:10.1021/acsmedchemlett.7b00344 PMID:29259744 PMCID:PMC5733266
- Velagapudi, S. P., Cameron, M. D., Haga, C. L., Rosenberg, L. H., Lafitte, M., Duckett, D. R., Phinney, D. G., Disney, M. D. Design of a small molecule against an oncogenic noncoding RNA Proceedings of the National Academy of Sciences of the United States of America 2016 113:5898-5903 DOI:10.1073/pnas.1523975113 PMID:27170187 PMCID:PMC4889373
- Rosenberg, L. H., Lafitte, M., Quereda, V., Grant, W., Chen, W., Bibian, M., Noguchi, Y., Fallahi, M., Yang, C., Chang, J. C., Roush, W. R., Cleveland, J. L., et al. Therapeutic targeting of casein kinase 1δ in breast cancer Science Translational Medicine 2015 7:318ra202 DOI:10.1126/scitranslmed.aac8773 PMID:26676609 PMCID:PMC4809734
- Saunders, V. C., Lafitte, M., Adrados, I., Quereda, V., Feurstein, D., Ling, Y., Fallahi, M., Rosenberg, L. H., Duckett, D. R. Identification of an EGFRvIII-JNK2-HGF/c-Met-signaling axis required for intercellular crosstalk and glioblastoma multiforme cell invasion Molecular Pharmacology 2015 88:962-969 DOI:10.1124/mol.115.097774 PMID:26452771
- Rosenberg, L. H., Lafitte, M., Grant, W., Chen, W., Cleveland, J. L., Duckett, D. R. Development of an HTS-compatible assay for the discovery of Ulk1 inhibitors Journal of Biomolecular Screening 2015 20:913-920 DOI:10.1177/1087057115579391 PMID:25851035 PMCID:PMC4744088
- Corzo, C. A., Mari, Y., Chang, M. R., Khan, T., Kuruvilla, D., Nuhant, P., Kumar, N., West, G. M., Duckett, D. R., Roush, W. R., Griffin, P. R. Antiproliferation activity of a small molecule repressor of liver receptor homolog 1 Molecular Pharmacology 2015 87:296-304 DOI:10.1124/mol.114.095554 PMID:25473120 PMCID:PMC4293447
- Sturchler, E., Chen, W., Spicer, T., Hodder, P., McDonald, P., Duckett, D. Development of an HTS-compatible assay for the discovery of ASK1 signalosome inhibitors using alphascreen technology Assay and Drug Development Technologies 2014 12:229-237 DOI:10.1089/adt.2013.558 PMID:24831789 PMCID:PMC4025566
- He, Y., Duckett, D., Chen, W., Ling, Y. Y., Cameron, M. D., Lin, L., Ruiz, C. H., Lograsso, P. V., Kamenecka, T. M., Koenig, M. Synthesis and SAR of novel isoxazoles as potent c-jun N-terminal kinase (JNK) inhibitors Bioorganic & Medicinal Chemistry Letters 2014 24:161-164 DOI:10.1016/j.bmcl.2013.11.052 PMID:24332487 PMCID:PMC4540177
- Bibian, M., Rahaim, R. J., Choi, J. Y., Noguchi, Y., Schurer, S., Chen, W. M., Nakanishi, S., Licht, K., Rosenberg, L. H., Li, L., Feng, Y., Cameron, M. D., et al. Development of highly selective casein kinase 1δ/1ε (CK1δ/ε) inhibitors with potent antiproliferative properties Bioorganic & Medicinal Chemistry Letters 2013 23:4374-4380 DOI:10.1016/j.bmcl.2013.05.075 PMID:23787102 PMCID:PMC3783656
- Jiang, R., Frackowiak, B., Shin, Y. S., Song, X. Y., Chen, W. M., Lin, L., Cameron, M. D., Duckett, D. R., Kamenecka, T. M. Design and synthesis of 1-aryl-5-anilinoindazoles as c-Jun N-terminal kinase inhibitors Bioorganic & Medicinal Chemistry Letters 2013 23:2683-2687 DOI:10.1016/j.bmcl.2013.02.082 PMID:23518277
- Sturchler, E., Feurstein, D., Chen, W. M., McDonald, P., Duckett, D. Stress-induced nuclear import of apoptosis signal-regulating kinase 1 is mediated by karyopherin alpha 2/beta 1 heterodimer Biochimica et Biophysica Acta-Molecular Cell Research 2013 1833:583-592 DOI:10.1016/j.bbamcr.2012.10.023 PMID:23123190
- Song, X., He, Y., Koenig, M., Shin, Y., Noel, R., Chen, W., Ling, Y. Y., Feurstein, D., Lin, L., Ruiz, C. H., Cameron, M. D., Duckett, D. R., et al. Synthesis and SAR of 2,4-diaminopyrimidines as potent c-jun n-terminal kinase inhibitors MedChemComm 2012 3:238-243 DOI:10.1039/c1md00219h
- Song, X. Y., Chen, W. M., Lin, L., Ruiz, C. H., Cameron, M. D., Duckett, D. R., Kamenecka, T. M. Synthesis and SAR of 2-phenoxypyridines as novel c-Jun N-terminal kinase inhibitors Bioorganic & Medicinal Chemistry Letters 2011 21:7072-7075 DOI:10.1016/j.bmcl.2011.09.090 PMID:22004719
- Hara, M. R., Kovacs, J. J., Whalen, E. J., Rajagopal, S., Strachan, R. T., Grant, W., Towers, A. J., Williams, B., Lam, C. M., Xiao, K. H., Shenoy, S. K., Gregory, S. G., et al. A stress response pathway regulates DNA damage through beta(2)-adrenoreceptors and beta-arrestin-1 Nature 2011 477:349-353 DOI:10.1038/nature10368 PMID:21857681 PMCID:PMC3628753
- Noel, R., Shin, Y., Song, X. Y., He, Y. J., Koenig, M., Chen, W. M., Ling, Y. Y., Lin, L., Ruiz, C. H., LoGrasso, P., Cameron, M. D., Duckett, D. R., et al. Synthesis and SAR of 4-(pyrazol-3-yl)-pyridines as novel c-jun N-terminal kinase inhibitors Bioorganic & Medicinal Chemistry Letters 2011 21:2732-2735 DOI:10.1016/j.bmcl.2010.11.104 PMID:21185177 PMCID:PMC3081976
- Chambers, J. W., Pachori, A., Howard, S., Ganno, M., Hansen, D., Song, X. Y., Kamenecka, T., Duckett, D., Chen, W. M., Ling, Y. Y., Cherry, L., Cameron, M. D. Small molecule c-jun-N-terminal Kinase (JNK) inhibitors protect dopaminergic neurons in a model of Parkinson's Disease ACS Chemical Neuroscience 2011 2:198-206 DOI:10.1021/cn100109k PMID:21666839 PMCID:PMC3110074
- He, Y. J., Kamenecka, T. M., Shin, Y. S., Song, X. Y., Jiang, R., Noel, R., Duckett, D., Chen, W. M., Ling, Y. Y., Cameron, M. D., Lin, L., Khan, S., et al. Synthesis and SAR of novel quinazolines as potent and brain-penetrant c-jun N-terminal kinase (JNK) inhibitors Bioorganic & Medicinal Chemistry Letters 2011 21:1719-1723 DOI:10.1016/j.bmcl.2011.01.079 PMID:21316221 PMCID:PMC3052630
- Kumar, N., Kojetin, D. J., Solt, L. A., Kumar, K. G., Nuhant, P., Duckett, D. R., Cameron, M. D., Butler, A. A., Roush, W. R., Griffin, P. R., Burris, T. P. Identification of SR3335 (ML-176): a synthetic RORα selective inverse agonist ACS Chemical Biology 2011 6:218-222 DOI:10.1021/cb1002762 PMID:21090593 PMCID:PMC3076127
- Hahmann, C., Weiser, A., Duckett, D., Schroeter, T. A predictive nuclear translocation assay for spliced x-box-binding protein 1 identifies compounds with known organ toxicities Assay and Drug Development Technologies 2011 9:79-87 DOI:10.1089/adt.2010.0300 PMID:20858054
- Duckett, D. R., Cameron, M. D. Metabolism considerations for kinase inhibitors in cancer treatment Expert Opinion on Drug Metabolism & Toxicology 2010 6:1175-1193 DOI:10.1517/17425255.2010.506873 PMID:20684746 PMCID:PMC2940961
- Sturchler, E., Feurstein, D., McDonald, P., Duckett, D. Mechanism of oxidative stress-induced ASK1-catalyzed MKK6 phosphorylation Biochemistry 2010 49:4094-4102 DOI:10.1021/bi100010j PMID:20364819
- Kamenecka, T., Jiang, R., Song, X. Y., Duckett, D., Chen, W. M., Ling, Y. Y., Habel, J., Laughlin, J. D., Chambers, J., Figuera-Losada, M., Cameron, M. D., Lin, L., et al. Synthesis, biological evaluation, X-ray structure, and pharmacokinetics of aminopyrimidine c-jun-N-terminal kinase (JNK) inhibitors Journal of Medicinal Chemistry 2010 53:419-431 DOI:10.1021/jm901351f PMID:19947601 PMCID:PMC2804074
- Yin, Y., Lin, L., Ruiz, C., Cameron, M. D., Pocas, J., Grant, W., Schroter, T., Chen, W. M., Duckett, D., Schurer, S., LoGrasso, P., Feng, Y. B. Benzothiazoles as Rho-associated kinase (ROCK-II) inhibitors Bioorganic & Medicinal Chemistry Letters 2009 19:6686-6690 DOI:10.1016/j.bmcl.2009.09.115 PMID:19837589
- Shin, Y. S., Chen, W. M., Habel, J., Duckett, D., Ling, Y. Y., Koenig, M., He, Y. J., Vojkovsky, T., LoGrasso, P., Kamenecka, T. M. Synthesis and sar of piperazine amides as novel c-jun N-terminal kinase (JNK) inhibitors Bioorganic & Medicinal Chemistry Letters 2009 19:3344-3347 DOI:10.1016/j.bmcl.2009.03.086 PMID:19433357 PMCID:PMC2737472
- Kamenecka, T., Habel, J., Duckett, D., Chen, W. M., Ling, Y. Y., Frackowiak, B., Jiang, R., Shin, Y. S., Song, X. Y., LoGrasso, P. Structure-activity relationships and X-ray structures describing the selectivity of aminopyrazole inhibitors for c-jun N-terminal kinase 3 (JNK3) over p38 Journal of Biological Chemistry 2009 284:12853-12861 DOI:10.1074/jbc.M809430200 PMID:19261605 PMCID:PMC2676016
- Chen, Y. T., Bannister, T. D., Weiser, A., Griffin, E., Lin, L., Ruiz, C., Cameron, M. D., Schurer, S., Duckett, D., Schroter, T., LoGrasso, P., Feng, Y. B. Chroman-3-amides as potent Rho kinase inhibitors Bioorganic & Medicinal Chemistry Letters 2008 18:6406-6409 DOI:10.1016/j.bmcl.2008.10.080 PMID:18990570
- Heerding, D. A., Rhodes, N., Leber, J. D., Clark, T. J., Keenan, R. M., Lafrance, L. V., Li, M., Safonov, I. G., Takata, D. T., Venslavsky, J. W., Yamashita, D. S., Choudhry, A. E., et al. Identification of 4-(2-(4-amino-1,2,5-oxadiazol-3-yl)-1-ethyl-7-{ (3s)-3-piperidinylmethyl oxy}-1H-imidazo 4,5-c pyridin-4-yl)-2-methyl-3-butyn-2-ol (GSK690693), a novel inhibitor of AKT kinase Journal of Medicinal Chemistry 2008 51:5663-5679 DOI:10.1021/jm8004527 PMID:18800763
- Rhodes, N., Heerding, D. A., Duckett, D. R., Eberwein, D. J., Knick, V. B., Lansing, T. J., McConnell, R. T., Gilmer, T. M., Zhang, S. Y., Robell, K., Kahana, J. A., Geske, R. S., et al. Characterization of an Akt kinase inhibitor with potent pharmacodynamic and antitumor activity Cancer Research 2008 68:2366-2374 DOI:10.1158/0008-5472.can-07-5783 PMID:18381444
- Jiang, R., Duckett, D., Chen, W., Habel, J., Ling, Y. Y., LoGrasso, P., Kamenecka, T. M. 3,5-disubstituted quinolines as novel c-Jun N-terminal kinase inhibitors Bioorganic & Medicinal Chemistry Letters 2007 17:6378-6382 DOI:10.1016/j.bmcl.2007.08.054 PMID:17911023
- Lansing, T. J., McConnell, R. T., Duckett, D. R., Spehar, G. M., Knick, V. B., Hassler, D. F., Noro, N., Furuta, M., Emmitte, K. A., Gilmer, T. M., Mook, R. A., Cheung, M. In vitro biological activity of a novel small-molecule inhibitor of polo-like kinase 1 Molecular Cancer Therapeutics 2007 6:450-459 DOI:10.1158/1535-7163.mct-06-0543 PMID:17267659
- Rech, J. C., Yato, M., Duckett, D., Ember, B., LoGrasso, P. V., Bergman, R. G., Ellman, J. A. Synthesis of potent bicyclic bisarylimidazole c-jun N-terminal kinase inhibitors by catalytic C-H bond activation Journal of the American Chemical Society 2007 129:490-491 DOI:10.1021/ja0676004 PMID:17227002 PMCID:PMC2556147
- Duckett, D. R., Bronstein, S. M., Taya, Y., Modrich, P. hMutS alpha- and hMutL alpha-dependent phosphorylation of p53 in response to DNA methylator damage Proceedings of the National Academy of Sciences of the United States of America 1999 96:12384-12388 DOI:10.1073/pnas.96.22.12384 PMID:10535931
- Walter, F., Murchie, A. I. H., Duckett, D. R., Lilley, D. M. J. Global structure of four-way RNA junctions studied using fluorescence resonance energy transfer RNA-a Publication of the RNA Society 1998 4:719-728 DOI:10.1017/s135583829898030x PMID:9622130
- Duckett, D. R., Murchie, A. I. H., Clegg, R. M., Bassi, G. S., Giraud-Panis, M. J. E., Lilley, D. M. J. Nucleic acid structure and recognition Biophysical Chemistry 1997 68:53-62 DOI:10.1016/s0301-4622(97)00007-0 PMID:17029905
- Mu, D., Tursun, M., Duckett, D. R., Drummond, J. T., Modrich, P., Sancar, A. Recognition and repair of compound DNA lesions (base damage and mismatch) by human mismatch repair and excision repair systems Molecular and Cellular Biology 1997 17:760-769 PMID:9001230 PMCID:PMC231802
- Duckett, D. R., Drummond, J. T., Murchie, A. I. H., Reardon, J. T., Sancar, A., Lilley, D. M., Modrich, P. Human muts alpha recognizes damaged DNA base pairs containing O6-methylguanine, O4-methylthymine, or the cisplatin-d(GpG) adduct Proceedings of the National Academy of Sciences of the United States of America 1996 93:6443-6447 DOI:10.1073/pnas.93.13.6443 PMID:8692834
- Duckett, D. R., Murchie, A. I. H., Lilley, D. M. J. The global folding of 4-way helical junctions in RNA, including that in U1 snRNA Cell 1995 83:1027-1036 DOI:10.1016/0092-8674(95)90218-x PMID:8521503
- Giraudpanis, M. J. E., Duckett, D. R., Lilley, D. M. J. The modular character of a DNA junction-resolving enzyme - a zinc-binding motif in bacteriophage-T4 endonuclease-VII Journal of Molecular Biology 1995 252:596-610 DOI:10.1006/jmbi.1995.0523 PMID:7563077
- Duckett, D. R., Panis, Mjeg, Lilley, D. M. J. Binding of the junction-resolving enzyme bacteriophage-T7 endonuclease-I to DNA - separation of binding and catalysis by mutation Journal of Molecular Biology 1995 246:95-107 DOI:10.1006/jmbi.1994.0069 PMID:7853409
- Duckett, D. R., Murchie, A. I. H., Giraudpanis, M. J. E., Pohler, J. R., Lilley, D. M. J. Structure of the four-way DNA junction and its interaction with proteins Philosophical Transactions of the Royal Society of London Series B-Biological Sciences 1995 347:27-36 DOI:10.1098/rstb.1995.0005 PMID:7746850
- Pohler, J. R. G., Duckett, D. R., Lilley, D. M. J. Structure of four-way DNA junctions containing a nick in one strand Journal of Molecular Biology 1994 238:62-74 DOI:10.1006/jmbi.1994.1268 PMID:8145257
- Welch, J. B., Duckett, D. R., Lilley, D. M. J. Structures of bulged three-way DNA junctions Nucleic Acids Research 1993 21:4548-4555 DOI:10.1093/nar/21.19.4548 PMID:8233789
- Lilley, D. M. J., Bhattacharyya, A., McAteer, S. P., Duckett, D. R. Gel-electrophoretic analysis of the structure of nucleic-acids Biochemical Society Transactions 1993 21:111-116 PMID:7680620
- Duckett, D. R., Murchie, A. I. H., Bhattacharyya, A., Clegg, R. M., Diekmann, S., Vonkitzing, E., Lilley, D. M. J. The structure of DNA junctions and their interaction with enzymes European Journal of Biochemistry 1992 207:285-295 DOI:10.1111/j.1432-1033.1992.tb17049.x PMID:8425539
- Duckett, D. R., Lilley, D. M. J. Effects of base mismatches on the structure of the four-way DNA junction Journal of Molecular Biology 1991 221:147-161 DOI:10.1016/0022-2836(91)90811-j PMID:1920402
- Duckett, D. R., Lilley, D. M. J. The three-way DNA junction is a Y-shaped molecule in which there is no helix-helix stacking EMBO Journal 1990 9:1659-1664 PMID:2328731 PMCID:PMC551862
- Duckett, D. R., Murchie, A. I. H., Lilley, D. M. J. The role of metal-ions in the conformation of the four-way DNA junction EMBO Journal 1990 9:583-590 PMID:2303044 PMCID:PMC551705
- Murchie, A. I. H., Clegg, R. M., Vonkitzing, E., Duckett, D. R., Diekmann, S., Lilley, D. M. J. Fluorescence energy-transfer shows that the four-way DNA junction is a right-handed cross of antiparallel molecules Nature 1989 341:763-766 DOI:10.1038/341763a0 PMID:2797209
- Duckett, D. R., Murchie, A. I. H., Diekmann, S., Vonkitzing, E., Kemper, B., Lilley, D. M. J. The structure of the Holliday junction, and its resolution Cell 1988 55:79-89 DOI:10.1016/0092-8674(88)90011-6 PMID:3167979