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Disney, Matthew
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Disney, Matthew

Faculty Member
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Positions

  • 2014 - Professor, Chemistry , Scripps Research
  • 2010 - Faculty Member, Skaggs Graduate School of Chemical and Biological Sciences , Scripps Research
  • 2010 - 2014 Associate Professor, Chemistry , Scripps Research
  • 2005 - 2010 Assistant Professor, University at Buffalo, The State University of New York
  • 2002 - 2005 Postdoctoral Fellow, Swiss Federal Institute of Technology Zurich (ETH)
Dr. Matthew Disney develops rational methods to target RNA with small molecules.

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  • disney@scripps.edu

Websites

  • Matthew David Disney, Ph.D.
  • Laboratory Website
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Publications

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    • Benhamou, R. I., Choudhary, S., Lekah, E., Tong, Y. Q., Disney, M. D. Bioinformatic Searching for Optimal RNA Targets of Dimeric Compounds Informs Design of a MicroRNA-27a Inhibitor ACS Chemical Biology  2022 17:5-10  DOI:10.1021/acschembio.1c00395  PMID:34898169
    • Ye, F., Haniff, H. S., Suresh, B. M., Yang, D., Zhang, P., Crynen, G., Teijaro, C. N., Yan, W., Abegg, D., Adibekian, A., Shen, B., Disney, M. D. Rational Approach to Identify RNA Targets of Natural Products Enables Identification of Nocathiacin as an Inhibitor of an Oncogenic RNA ACS Chemical Biology  2022 17:474-482  DOI:10.1021/acschembio.1c00952  PMID:35044149
    • Zhang, P., Liu, X. H., Abegg, D., Tanaka, T., Tong, Y., Benhamou, R. I., Baisden, J., Crynen, G., Meyer, S. M., Cameron, M. D., Chatterjee, A. K., Adibekian, A., et al. Reprogramming of Protein-Targeted Small-Molecule Medicines to RNA by Ribonuclease Recruitment Journal of the American Chemical Society  2021 143:13044-13055  DOI:10.1021/jacs.1c02248  PMID:34387474
    • Haify, S. N., Buijsen, R. A. M., Verwegen, L., Severijnen, Lawfm, de Boer, H., Boumeester, V., Monshouwer, R., Yang, W. Y., Cameron, M. D., Willemsen, R., Disney, M. D., Hukema, R. K. Small molecule 1a reduces FMRpolyG-mediated toxicity in in vitro and in vivo models for FMR1 premutation Human Molecular Genetics  2021 30:1632-1648  DOI:10.1093/hmg/ddab143  PMID:34077515  PMCID:PMC8369842
    • Hall, M. D., Anderson, J. M., Anderson, A., Baker, D., Bradner, J., Brimacombe, K. R., Campbell, E. A., Corbett, K. S., Carter, K., Cherry, S., Chiang, L. L., Cihlar, T., et al. Report of the National Institutes of Health SARS-CoV-2 Antiviral Therapeutics Summit Journal of Infectious Diseases  2021 224:S1-S21  DOI:10.1093/infdis/jiab305  PMID:34111271  PMCID:PMC8280938
    • Bush, J. A., Williams, C. C., Meyer, S. M., Tong, Y., Haniff, H. S., Childs-Disney, J. L., Disney, M. D. Systematically Studying the Effect of Small Molecules Interacting with RNA in Cellular and Preclinical Models ACS Chemical Biology  2021 16:1111-1127  DOI:10.1021/acschembio.1c00014  PMID:34166593
    • Disney, M. D. A glimpse at the glycoRNA world Cell  2021 184:3080-3081  DOI:10.1016/j.cell.2021.05.025  PMID:34115968
    • Vezina-Dawod, S., Angelbello, A. J., Choudhary, S., Wang, K. W., Yildirim, I., Disney, M. D. Massively Parallel Optimization of the Linker Domain in Small Molecule Dimers Targeting a Toxic r(CUG) Repeat Expansion ACS Medicinal Chemistry Letters  2021 12:907-914  DOI:10.1021/acsmedchemlett.1c00027  PMID:34141068  PMCID:PMC8201483
    • Ursu, A., Baisden, J. T., Bush, J. A., Taghavi, A., Choudhary, S., Zhang, Y. J., Gendron, T. F., Petrucelli, L., Yildirim, I., Disney, M. D. A Small Molecule Exploits Hidden Structural Features within the RNA Repeat Expansion That Causes c9ALS/FTD and Rescues Pathological Hallmarks ACS Chemical Neuroscience  2021 12:4076-4089  DOI:10.1021/acschemneuro.1c00470  PMID:34677935
    • Bush, J. A., Aikawa, H., Fuerst, R., Li, Y., Ursu, A., Meyer, S. M., Benhamou, R. I., Chen, J. L., Khan, T., Wagner-Griffin, S., Van Meter, M. J., Tong, Y., et al. Ribonuclease recruitment using a small molecule reduced c9ALS/FTD r(G(4)C(2)) repeat expansion in vitro and in vivo ALS models Science Translational Medicine  2021 13  DOI:10.1126/scitranslmed.abd5991  PMID:34705518
    • Suresh, B. M., Li, W. C., Zhang, P., Wang, K. W., Yildirim, I., Parker, C. G., Disney, M. D. A general fragment-based approach to identify and optimize bioactive ligands targeting RNA Proceedings of the National Academy of Sciences of the United States of America  2020 117:33197-33203  DOI:10.1073/pnas.2012217117  PMID:33318191  PMCID:PMC7777249
    • Ursu, A., Wang, K. W., Bush, J. A., Choudhary, S., Chen, J. L., Baisden, J. T., Zhang, Y. J., Gendron, T. F., Petrucelli, L., Yildirim, I., Disney, M. D. Structural Features of Small Molecules Targeting the RNA Repeat Expansion That Causes Genetically Defined ALS/FTD ACS Chemical Biology  2020 15:3112-3123  DOI:10.1021/acschembio.0c00049  PMID:33196168  PMCID:PMC7788565
    • Angelbello, A. J., Benhamou, R. I., Rzuczek, S. G., Choudhary, S., Tang, Z. Z., Chen, J. L., Roy, M., Wang, K. W., Yildirim, I., Jun, A. S., Thornton, C. A., Disney, M. D. A Small Molecule that Binds an RNA Repeat Expansion Stimulates Its Decay via the Exosome Complex Cell Chemical Biology  2020 28:34-45  DOI:10.1016/j.chembiol.2020.10.007  PMID:33157036  PMCID:PMC7855261
    • Ursu, A., Childs-Disney, J. L., Andrews, R. J., O'Leary, C. A., Meyer, S. M., Angelbello, A. J., Moss, W. N., Disney, M. D. Design of small molecules targeting RNA structure from sequence Chemical Society Reviews  2020 49:7252-7270  DOI:10.1039/d0cs00455c  PMID:32935689  PMCID:PMC7707016
    • Meyer, S. M., Williams, C. C., Akahori, Y., Tanaka, T., Aikawa, H., Tong, Y., Childs-Disney, J. L., Disney, M. D. Small molecule recognition of disease-relevant RNA structures Chemical Society Reviews  2020 49:7167-7199  DOI:10.1039/d0cs00560f  PMID:32975549
    • Haniff, H. S., Tong, Y., Liu, X. H., Chen, J. L., Suresh, B. M., Andrews, R. J., Peterson, J. M., O'Leary, C. A., Benhamou, R. I., Moss, W. N., Disney, M. D. Targeting the SARS-CoV-2 RNA Genome with Small Molecule Binders and Ribonuclease Targeting Chimera (RIBOTAC) Degraders ACS Central Science  2020 6:1713-1721  DOI:10.1021/acscentsci.0c00984  PMID:33140033  PMCID:PMC7553039
    • Haniff, H. S., Knerr, L., Chen, J. L., Disney, M. D., Lightfoot, H. L. Target-Directed Approaches for Screening Small Molecules against RNA Targets SLAS Discovery  2020  DOI:10.1177/2472555220922802  PMID:32419578
    • Benhamou, R. I., Vezina-Dawod, S., Choudhary, S., Wang, K. W., Meyer, S. M., Yildirim, I., Disney, M. D. Macrocyclization of a Ligand Targeting a Toxic RNA Dramatically Improves Potency Chembiochem  2020  DOI:10.1002/cbic.202000445  PMID:32649032
    • Haniff, H. S., Knerr, L., Liu, X. H., Crynen, G., Bostrom, J., Abegg, D., Adibekian, A., Lekah, E., Wang, K. W., Cameron, M. D., Yildirim, I., Lemurell, M., et al. Design of a small molecule that stimulates vascular endothelial growth factor A enabled by screening RNA fold-small molecule interactions Nature Chemistry  2020 12:952-961  DOI:10.1038/s41557-020-0514-4  PMID:32839603
    • Benhamou, R. I., Abe, M., Choudhary, S., Meyer, S. M., Angelbello, A. J., Disney, M. D. Optimization of the Linker Domain in a Dimeric Compound that Degrades an r(CUG) Repeat Expansion in Cells Journal of Medicinal Chemistry  2020 63:7827-7839  DOI:10.1021/acs.jmedchem.0c00558  PMID:32657583  PMCID:PMC7450518
    • Angelbello, A. J., Disney, M. D. A Toxic RNA Templates the Synthesis of Its Own Fluorogenic Inhibitor by Using a Bio-orthogonal Tetrazine Ligation in Cells and Tissues ACS Chemical Biology  2020 15:1820-1825  DOI:10.1021/acschembio.0c00417  PMID:32551539  PMCID:PMC7392402
    • Ursu, A., Childs-Disney, J. L., Angelbello, A. J., Costales, M. G., Meyer, S. M., Disney, M. D. Gini Coefficients as a Single Value Metric to Define Chemical Probe Selectivity ACS Chemical Biology  2020 15:2031-2040  DOI:10.1021/acschembio.0c00486  PMID:32568503  PMCID:PMC7442733
    • Angelbello, A. J., Chen, J. L., Disney, M. D. Small molecule targeting of RNA structures in neurological disorders Annals of the New York Academy of Sciences  2020 1471:57-71  DOI:10.1111/nyas.14051  PMID:30964958  PMCID:PMC6785366
    • Disney, M. D., Suresh, B. M., Benhamou, R. I., Childs-Disney, J. L. Progress toward the development of the small molecule equivalent of small interfering RNA Current Opinion in Chemical Biology  2020 56:63-71  DOI:10.1016/j.cbpa.2020.01.001  PMID:32036231  PMCID:PMC7311281
    • Chen, J. L., Zhang, P., Abe, M., Aikawa, H., Zhang, L., Frank, A. J., Zembryski, T., Hubbs, C., Park, H., Withka, J., Steppan, C., Rogers, L., et al. Design, Optimization, and Study of Small Molecules That Target Tau Pre-mRNA and Affect Splicing Journal of the American Chemical Society  2020 142:8706-8727  DOI:10.1021/jacs.0c00768  PMID:32364710
    • Todd, T. W., McEachin, Z. T., Chew, J., Burch, A. R., Jansen-West, K., Tong, J. M., Yue, M., Song, Y. P., Castanedes-Casey, M., Kurti, A., Dunmore, J. H., Fryer, J. D., et al. Hexanucleotide Repeat Expansions in c9FTD/ALS and SCA36 Confer Selective Patterns of Neurodegeneration In Vivo Cell Reports  2020 31  DOI:10.1016/j.celrep.2020.107616  PMID:32375043
    • Angelbello, A. J., Defeo, M. E., Glinkerman, C. M., Boger, D. L., Disney, M. D. Precise Targeted Cleavage of a r(CUG) Repeat Expansion in Cells by Using a Small-Molecule-Deglycobleomycin Conjugate ACS Chemical Biology  2020 15:849-855  DOI:10.1021/acschembio.0c00036  PMCID:32186845
    • Liu, X. H., Haniff, H. S., Childs-Disney, J. L., Shuster, A., Aikawa, H., Adibekian, A., Disney, M. D. Targeted Degradation of the Oncogenic MicroRNA 17-92 Cluster by Structure-Targeting Ligands Journal of the American Chemical Society  2020 142:6970-6982  DOI:10.1021/jacs.9b13159  PMID:32233464
    • Costales, M. G., Childs-Disney, J. L., Haniff, H. S., Disney, M. D. How We Think about Targeting RNA with Small Molecules Journal of Medicinal Chemistry  2020 63:8880-8900  DOI:10.1021/acs.jmedchem.9b01927  PMID:32212706  PMCID:PMC7486258
    • Benhamou, R. I., Angelbello, A. J., Wang, E. T., Disney, M. D. A toxic RNA catalyzes the cellular synthesis of its own inhibitor, shunting it to endogenous decay pathways Cell Chemical Biology  2020 27:223-231  DOI:10.1016/j.chembiol.2020.01.003  PMID:31981476  PMCID:PMC7081931
    • Costales, M. G., Aikawa, H., Li, Y., Childs-Disney, J. L., Abegg, D., Hoch, D. G., Velagapudi, S. P., Nakai, Y., Khan, T., Wang, K. W., Yildirim, I., Adibekian, A., et al. Small-molecule targeted recruitment of a nuclease to cleave an oncogenic RNA in a mouse model of metastatic cancer Proceedings of the National Academy of Sciences of the United States of America  2020 117:2406-2411  DOI:10.1073/pnas.1914286117  PMID:31964809  PMCID:PMC7007575
    • Benhamou, R. I., Angelbello, A. J., Andrews, R. J., Wang, E. T., Moss, W. N., Disney, M. D. Structure-specific cleavage of an RNA repeat expansion with a dimeric small molecule is advantageous over sequence-specific recognition by an oligonucleotide ACS Chemical Biology  2020 15:485-493  DOI:10.1021/acschembio.9b00958  PMID:31927948  PMCID:PMC7081929
    • Zhang, P., Park, H. J., Zhang, J., Junn, E., Andrews, R. J., Velagapudi, S. P., Abegg, D., Vishnu, K., Costales, M. G., Childs-Disney, J. L., Adibekian, A., Moss, W. N., et al. Translation of the intrinsically disordered protein α-synuclein is inhibited by a small molecule targeting its structured mRNA Proceedings of the National Academy of Sciences of the United States of America  2020 117:1457-1467  DOI:10.1073/pnas.1905057117  PMID:31900363  PMCID:PMC6983430
    • Ursu, A., Vezina-Dawod, S., Disney, M. D. Methods to identify and optimize small molecules interacting with RNA (SMIRNAs) Drug Discovery Today  2019 24:2002-2016  DOI:10.1016/j.drudis.2019.06.019  PMID:31356880  PMCID:PMC6842402
    • Costales, M. G., Suresh, B., Vishnu, K., Disney, M. D. Targeted degradation of a hypoxia-associated non-coding RNA enhances the selectivity of a small molecule interacting with RNA Cell Chemical Biology  2019 26:1180-1186  DOI:10.1016/j.chembiol.2019.04.008  PMID:31130520  PMCID:PMC6697612
    • Chen, J. L., Moss, W. N., Spencer, A., Zhang, P., Childs-Disney, J. L., Disney, M. D. The RNA encoding the microtubule-associated protein tau has extensive structure that affects its biology PLoS One  2019 14  DOI:10.1371/journal.pone.0219210  PMID:31291322  PMCID:PMC6619747
    • O'Leary, C. A., Andrews, R. J., Tompkins, V., Chen, J. L., Childs-Disney, J. L., Disney, M. D., Moss, W. N. RNA structural analysis of the MYC mRNA reveals conserved motifs that affect gene expression PLoS One  2019 14  DOI:10.1371/journal.pone.0213758  PMID:31206539  PMCID:PMC6576772
    • Velagapudi, S. P., Li, Y., Disney, M. D. A cross-linking approach to map small molecule-RNA binding sites in cells Bioorganic & Medicinal Chemistry Letters  2019 29:1532-1536  DOI:10.1016/j.bmcl.2019.04.001  PMID:30987892
    • Disney, M. D. Targeting RNA with small molecules to capture opportunities at the intersection of chemistry, biology, and medicine Journal of the American Chemical Society  2019 141:6776-6790  DOI:10.1021/jacs.8b13419  PMID:30896935
    • Costales, M. G., Disney, M. D. Adding broccoli to the biosensor menu Cell Chemical Biology  2019 26:463-465  DOI:10.1016/j.chembiol.2019.04.004  PMID:31002799
    • Angelbello, A. J., Rzuczek, S. G., McKee, K. K., Chen, J. L., Olafson, H., Cameron, M. D., Moss, W. N., Wang, E. T., Disney, M. D. Precise small-molecule cleavage of an r(CUG) repeat expansion in a myotonic dystrophy mouse model Proceedings of the National Academy of Sciences of the United States of America  2019 116:7799-7804  DOI:10.1073/pnas.1901484116  PMID:30926669  PMCID:PMC6475439
    • Wang, Z. F., Ursu, A., Childs-Disney, J. L., Guertler, R., Yang, W. Y., Bernat, V., Rzuczek, S. G., Fuerst, R., Zhang, Y. J., Gendron, T. F., Yildirim, I., Dwyer, B. G., et al. The hairpin form of r(G(4)C(2))(exp) in c9ALS/FTD is repeat-associated non-ATG translated and a target for bioactive small molecules Cell Chemical Biology  2019 26:179-190  DOI:10.1016/j.chembiol.2018.10.018  PMID:30503283  PMCID:PMC6386614
    • Costales, M. G., Hoch, D. G., Abegg, D., Childs-Disney, J. L., Velagapudi, S. P., Adibekian, A., Disney, M. D. A designed small molecule inhibitor of a non-coding RNA sensitizes HER2 negative cancers to herceptin Journal of the American Chemical Society  2019 141:2960-2974  DOI:10.1021/jacs.8b10558  PMID:30726072  PMCID:PMC6400281
    • Chew, J., Cook, C., Gendron, T. F., Jansen-West, K., del Rosso, G., Daughrity, L. M., Castanedes-Casey, M., Kurti, A., Stankowski, J. N., Disney, M. D., Rothstein, J. D., Dickson, D. W., et al. Aberrant deposition of stress granule-resident proteins linked to C9orf72-associated TDP-43 proteinopathy Molecular Neurodegeneration  2019 14  DOI:10.1186/s13024-019-0310-z  PMID:30767771  PMCID:PMC6377782
    • Wales, D. J., Disney, M. D., Yildirim, I. Computational investigation of RNA A-bulges related to the microtubule-associated protein tau causing frontotemporal dementia and Parkinsonism Journal of Physical Chemistry B  2019 123:57-65  DOI:10.1021/acs.jpcb.8b09139  PMID:30517788
    • Disney, M. D., Velagapudi, S. P., Li, Y., Costales, M. G., Childs-Disney, J. L. Identifying and validating small molecules interacting with RNA (SMIRNAs) Methods in Enzymology  2019 623:45-66  DOI:10.1016/bs.mie.2019.04.027  PMID:31239057  PMCID:PMC6628145
    • Disney, M. D., Dwyer, B. G., Childs-Disney, J. L. Drugging the RNA world Cold Spring Harbor Perspectives in Biology  2018 10  DOI:10.1101/cshperspect.a034769  PMID:30385607
    • Li, Y., Disney, M. D. Precise small molecule degradation of a noncoding RNA identifies cellular binding sites and modulates an oncogenic phenotype ACS Chemical Biology  2018 13:3065-3071  DOI:10.1021/acschembio.8b00827  PMID:30375843
    • Disney, M. D. Introduction to the Symposium In Print for Laura Kiessling Bioorganic & Medicinal Chemistry  2018 26:III-III  DOI:10.1016/j.bmc.2018.10.021  PMID:30420097
    • Childs-Disney, J. L., Tran, T., Vummidi, B. R., Velagapudi, S. P., Haniff, H. S., Matsumoto, Y., Crynen, G., Southern, M. R., Biswas, A., Wang, Z., Tellinghuisen, T. L., Disney, M. D. A massively parallel selection of small molecule-RNA motif binding partners informs design of an antiviral from sequence Chem  2018 4:2384-2404  DOI:10.1016/j.chempr.2018.08.003
    • Velagapudi, S. P., Costales, M. G., Vummidi, B. R., Nakai, Y., Angelbello, A. J., Tran, T., Haniff, H. S., Matsumoto, Y., Wang, Z. F., Chatterjee, A. K., Childs-Disney, J. L., Disney, M. D. Approved anti-cancer drugs target oncogenic non-coding RNAs Cell Chemical Biology  2018 25:1086-1094  DOI:10.1016/j.chembiol.2018.05.015  PMID:30251629
    • Disney, M. D., Janda, K. D. Introduction Bioorganic & Medicinal Chemistry Letters  2018 28:2661-2662  DOI:10.1016/j.bmcl.2018.07.013  PMID:30029841
    • Guan, L., Luo, Y., Ja, W. W., Disney, M. D. Small molecule alteration of RNA sequence in cells and animals Bioorganic & Medicinal Chemistry Letters  2018 28:2794-2796  DOI:10.1016/j.bmcl.2018.10.034  PMID:29079470  PMCID:PMC5906209
    • Haniff, H. S., Graves, A., Disney, M. D. Selective small molecule recognition of RNA base pairs ACS Combinatorial Science  2018 20:482-491  DOI:10.1021/acscombsci.8b00049  PMID:29966095
    • Costales, M. G., Matsumoto, Y., Velagapudi, S. P., Disney, M. D. Small molecule targeted recruitment of a nuclease to RNA Journal of the American Chemical Society  2018 140:6741-6744  DOI:10.1021/jacs.8b01233  PMID:29792692
    • Angelbello, A. J., Chen, J. L., Childs-Disney, J. L., Zhang, P., Wang, Z. F., Disney, M. D. Using genome sequence to enable the design of medicines and chemical probes Chemical Reviews  2018 118:1599-1663  DOI:10.1021/acs.chemrev.7b00504  PMID:29322778
    • Angelbello, A. J., Disney, M. D. Bleomycin can cleave an oncogenic noncoding RNA ChemBioChem  2018 19:43-47  DOI:10.1002/cbic.201700581  PMID:29084369
    • Chen, J. L., VanEtten, D. M., Fountain, M. A., Yildirim, I., Disney, M. D. Structure and dynamics of RNA repeat expansions that cause Huntington's disease and myotonic dystrophy type 1 Biochemistry  2017 56:3463-3474  DOI:10.1021/acs.biochem.7b00252  PMID:28617590
    • Disney, M. D. Inhibiting translation one protein at a time Trends in Biochemical Sciences  2017 42:412-413  DOI:10.1016/j.tibs.2017.04.008  PMID:28522328
    • Gendron, T. F., Chew, J., Stankowski, J. N., Hayes, L. R., Zhang, Y. J., Prudencio, M., Carlomagno, Y., Daughrity, L. M., Jansen-West, K., Perkerson, E. A., O'Raw, A., Cook, C., et al. Poly(GP) proteins are a useful pharmacodynamic marker for C9ORF72-associated amyotrophic lateral sclerosis Science Translational Medicine  2017 9  DOI:10.1126/scitranslmed.aai7866  PMID:28356511
    • Velagapudi, S. P., Luo, Y., Tran, T., Haniff, H. S., Nakai, Y., Fallahi, M., Martinez, G. J., Childs-Disney, J. L., Disney, M. D. Defining RNA small molecule affinity landscapes enables design of a small molecule inhibitor of an oncogenic noncoding RNA ACS Central Science  2017 3:205-216  DOI:10.1021/acscentsci.7b00009  PMID:28386598  PMCID:PMC5364451
    • Costales, M. G., Childs-Disney, J. L., Disney, M. D. Computational tools for design of selective small molecules targeting RNA: from small molecule microarrays to chemical similarity searching Topics in Medicinal Chemistry  2017 27:1-16
    • Costales, M. G., Haga, C. L., Velagapudi, S. P., Childs-Disney, J. L., Phinney, D. G., Disney, M. D. Small molecule inhibition of microRNA-210 reprograms an oncogenic hypoxic circuit Journal of the American Chemical Society  2017 139:3446-3455  DOI:10.1021/jacs.61311273  PMID:28240549
    • Rzuczek, S. G., Colgan, L. A., Nakai, Y., Cameron, M. D., Furling, D., Yasuda, R., Disney, M. D. Precise small-molecule recognition of a toxic CUG RNA repeat expansion Nature Chemical Biology  2017 13:188-193  DOI:10.1038/nchembio.2251  PMID:27941760  PMCID:PMC5290590
    • Disney, M. D. Rational design of small molecules targeting oncogenic noncoding RNAs from sequence Accounts of Chemical Research  2016 49:2698-2704  DOI:10.1021/acs.accounts.6b00326  PMID:27993012
    • Park, H., Tran, T., Lee, J. H., Park, H., Disney, M. D. Controlled dehydration improves the diffraction quality of two RNA crystals BMC Structural Biology  2016 16  DOI:10.1186/s12900-016-0069-1  PMID:27809904  PMCID:PMC5093936
    • Disney, M. D. Chemistry and chemical biology of therapeutically important compounds [Preface] Bioorganic & Medicinal Chemistry  2016 24:3875-3875  DOI:10.1016/j.bmc.2016.06.049  PMID:27460698
    • Yang, W. Y., He, F., Strack, R. L., Oh, S. Y., Frazer, M., Jaffrey, S. R., Todd, P. K., Disney, M. D. Small molecule recognition and tools to study modulation of r(CGG)(exp) in fragile X-associated tremor ataxia syndrome ACS Chemical Biology  2016 11:2456-2465  DOI:10.1021/acschembio.6b00147  PMID:27276216
    • Costales, M. G., Rzuczek, S. G., Disney, M. D. Comparison of small molecules and oligonucleotides that target a toxic, non-coding RNA Bioorganic & Medicinal Chemistry Letters  2016 26:2605-2609  DOI:10.1016/j.bmcl.2016.04.025  PMID:27117425
    • Yang, W. Y., Gao, R., Southern, M., Sarkar, P. S., Disney, M. D. Design of a bioactive small molecule that targets r(AUUCU) repeats in spinocerebellar ataxia 10 Nature Communications  2016 7  DOI:10.1038/ncomms11647  PMID:27248057  PMCID:27248057
    • Disney, M. D., Winkelsas, A. M., Velagapudi, S. P., Southern, M., Fallahi, M., Childs-Disney, J. L. Inforna 2.0: a platform for the sequence-based design of small molecules targeting structured RNAs ACS Chemical Biology  2016 11:1720-1728  DOI:10.1021/acschembio.6b00001  PMID:27097021  PMCID:PMC4912454
    • Velagapudi, S. P., Cameron, M. D., Haga, C. L., Rosenberg, L. H., Lafitte, M., Duckett, D. R., Phinney, D. G., Disney, M. D. Design of a small molecule against an oncogenic noncoding RNA Proceedings of the National Academy of Sciences of the United States of America  2016 113:5898-5903  DOI:10.1073/pnas.1523975113  PMID:27170187  PMCID:PMC4889373
    • Liu, B., Childs-Disney, J. L., Znosko, B. M., Wang, D., Fallahi, M., Gallo, S. M., Disney, M. D. Analysis of secondary structural elements in human microRNA hairpin precursors BMC Bioinformatics  2016 17  DOI:10.1186/s12859-016-0960-6  PMID:26928172  PMCID:PMC4772329
    • Childs-Disney, J. L., Disney, M. D. Small molecule targeting of a microRNA associated with hepatocellular carcinoma ACS Chemical Biology  2016 11:375-380  DOI:10.1021/acschembio.5b00615  PMID:26551630  PMCID:PMC4856042
    • Gonzalez, A. L., Rzuczek, S. G., Disney, M. D. Development of pharmacophore models for small molecules targeting RNA: Application to the RNA repeat expansion in myotonic dystrophy type 1 Bioorganic & Medicinal Chemistry Letters  2016 26:5792-5796  DOI:10.1016/j.bmcl.2016.10.037  PMID:27839685
    • Rzuczek, S. G., Southern, M. R., Disney, M. D. Studying a drug-like, RNA-focused small molecule library identifies compounds that inhibit RNA toxicity in myotonic dystrophy ACS Chemical Biology  2015 10:2706-2715  DOI:10.1021/acschembio.5b00430  PMID:26414664  PMCID:PMC4903160
    • Garbaccio, R. M., Johnson, D. S., Hong, J., Disney, M. D. Recent advances in medicinal chemistry and chemical biology. Preface. Bioorganic & Medicinal Chemistry Letters  2015 25:4714-4714  DOI:10.1016/j.bmcl.2015.08.083
    • Yildirim, I., Chakraborty, D., Disney, M. D., Wales, D. J., Schatz, G. C. Computational investigation of RNA CUG repeats responsible for myotonic dystrophy 1 Journal of Chemical Theory and Computation  2015 11:4943-4958  DOI:10.1021/acs.jctc.5b00728  PMID:26500461  PMCID:PMC4606397
    • Haga, C. L., Velagapudi, S. P., Strivelli, J. R., Yang, W. Y., Disney, M. D., Phinney, D. G. Small molecule inhibition of miR-544 biogenesis disrupts adaptive responses to hypoxia by modulating ATM-mTOR signaling ACS Chemical Biology  2015 10:2267-2276  DOI:10.1021/acschembio.5b00265  PMID:26181590  PMCID:PMC4876818
    • Bernat, V., Disney, M. D. RNA structures as mediators of neurological diseases and as drug targets Neuron  2015 87:28-46  DOI:10.1016/j.neuron.2015.06.012  PMID:26139368  PMCID:PMC4508199
    • Park, H., Gonzalez, A. L., Yildirim, I., Tran, T., Lohman, J. R., Fang, P., Guo, M., Disney, M. D. Crystallographic and computational analyses of AUUCU repeating RNA that causes spinocerebellar ataxia type 10 (SCA10) Biochemistry  2015 54:3851-3859  DOI:10.1021/acs.biochem.5b00551  PMID:26039897  PMCID:PMC4876817
    • Yang, W. Y., Wilson, H. D., Velagapudi, S. P., Disney, M. D. Inhibition of non-ATG translational events in cells via covalent small molecules targeting RNA Journal of the American Chemical Society  2015 137:5336-5345  DOI:10.1021/ja507448y  PMID:25825793  PMCID:PMC4856029
    • Velagapudi, S. P., Vummidi, B. R., Disney, M. D. Small molecule chemical probes of microRNA function Current Opinion in Chemical Biology  2015 24:97-103  DOI:10.1016/j.cbpa.2014.10.024  PMID:25500006  PMCID:PMC4382669
    • Rzuczek, S. G., Park, H., Disney, M. D. A toxic RNA catalyzes the in cellulo synthesis of its own inhibitor Angewandte Chemie-International Edition  2014 53:10956-10959  DOI:10.1002/anie.201406465  PMID:25164984
    • Luo, Y., Disney, M. D. Bottom-up design of small molecules that stimulate exon 10 skipping in mutant MAPT pre-mRNA ChemBioChem  2014 15:2041-2044  DOI:10.1002/cbic.201402069  PMID:25115866  PMCID:PMC4334360
    • Disney, M. D. Anti-cancer compound designed rationally TrAC Trends in Analytical Chemistry  2014 56:iv-v  DOI:10.1016/j.trac.2014.02.001
    • Velagapudi, S. P., Gallo, S. M., Disney, M. D. Sequence-based design of bioactive small molecules that target precursor microRNAs Nature Chemical Biology  2014 10:291-297  DOI:10.1038/nchembio.1452  PMID:24509821  PMCID:PMC3962094
    • Tran, T., Childs-Disney, J. L., Liu, B., Guan, L. R., Rzuczek, S., Disney, M. D. Targeting the r(CGG) repeats that cause FXTAS with modularly assembled small molecules and oligonucleotides ACS Chemical Biology  2014 9:904-912  DOI:10.1021/cb400875u  PMID:24506227  PMCID:PMC4287843
    • Colak, D., Zaninovic, N., Cohen, M. S., Rosenwaks, Z., Yang, W. Y., Gerhardt, J., Disney, M. D., Jaffrey, S. R. Promoter-bound trinucleotide repeat mRNA drives epigenetic silencing in fragile X syndrome Science  2014 343:1002-1005  DOI:10.1126/science.1245831  PMID:24578575  PMCID:PMC4357282
    • Childs-Disney, J. L., Yildirim, I., Park, H., Lohman, J. R., Guan, L., Tran, T., Sarkar, P., Schatz, G. C., Disney, M. D. Structure of the myotonic dystrophy type 2 RNA and designed small molecules that reduce toxicity ACS Chemical Biology  2014 9:538-550  DOI:10.1021/cb4007387  PMID:24341895  PMCID:PMC3944380
    • Su, Z., Zhang, Y., Gendron, T. F., Bauer, P. O., Chew, J., Yang, W. Y., Fostvedt, E., Jansen-West, K., Belzil, V. V., Desaro, P., Johnston, A., Overstreet, K., et al. Discovery of a biomarker and lead small molecules to target r(GGGGCC)-associated defects in c9FTD/ALS Neuron  2014 83:1043-1050  DOI:10.1016/j.neuron.2014.07.041  PMID:25132468  PMCID:PMC4232217
    • Disney, M. D., Yildirim, I., Childs-Disney, J. L. Methods to enable the design of bioactive small molecules targeting RNA Organic & Biomolecular Chemistry  2014 12:1029-1039  DOI:10.1039/c3ob42023j  PMID:24357181  PMCID:PMC4020623
    • Velagapudi, S. P., Disney, M. D. Two-dimensional combinatorial screening enables the bottom-up design of a microRNA-10b inhibitor Chemical Communications  2014 50:3027-3029  DOI:10.1039/c3cc00173c  PMID:24503738  PMCID:PMC4040211
    • Strack, R. L., Disney, M. D., Jaffrey, S. R. A superfolding Spinach2 reveals the dynamic nature of trinucleotide repeat-containing RNA Nature Methods  2013 10:1219-1224  DOI:10.1038/nmeth.2701  PMID:24162923  PMCID:PMC3852148
    • Disney, M. D. Rational design of chemical genetic probes of RNA function and lead therapeutics targeting repeating transcripts Drug Discovery Today  2013 18:1228-1236  DOI:10.1016/j.drudis.2013.07.024  PMID:23939337  PMCID:PMC3849211
    • Velagapudi, S. P., Disney, M. D. Defining RNA motif-aminoglycoside interactions via two-dimensional combinatorial screening and structure-activity relationships through sequencing Bioorganic & Medicinal Chemistry  2013 21:6132-6138  DOI:10.1016/j.bmc.2013.04.072  PMID:23719281  PMCID:PMC3789863
    • Rzuczek, S. G., Gao, Y., Tang, Z. Z., Thornton, C. A., Kodadek, T., Disney, M. D. Features of modularly assembled compounds that impart bioactivity against an RNA target ACS Chemical Biology  2013 8:2312-2321  DOI:10.1021/cb400265y  PMID:24032410  PMCID:PMC3876286
    • Guan, L., Disney, M. D. Covalent small-molecule-RNA complex formation enables cellular profiling of small-molecule-RNA interactions Angewandte Chemie-International Edition  2013 52:10010-10013  DOI:10.1002/anie.201301639  PMID:23913698  PMCID:PMC3876275
    • Childs-Disney, J. L., Stepniak-Konieczna, E., Tran, T., Yildirim, I., Park, H., Chen, C. Z., Hoskins, J., Southall, N., Marugan, J. J., Patnaik, S., Zheng, W., Austin, C. P., et al. Induction and reversal of myotonic dystrophy type 1 pre-mRNA splicing defects by small molecules Nature Communications  2013 4:2044  DOI:10.1038/ncomms3044  PMID:23806903  PMCID:PMC3710115
    • Yildirim, I., Park, H., Disney, M. D., Schatz, G. C. A dynamic structural model of expanded RNA CAG repeats: A refined X-ray structure and computational investigations using molecular dynamics and umbrella sampling simulations Journal of the American Chemical Society  2013 135:3528-3538  DOI:10.1021/ja3108627  PMID:23441937  PMCID:PMC3625063
    • Sellier, C., Freyermuth, F., Tabet, R., Tran, T., He, F., Ruffenach, F., Alunni, V., Moine, H., Thibault, C., Page, A., Tassone, F., Willemsen, R., et al. Sequestration of DROSHA and DGCR8 by expanded CGG RNA repeats alters microRNA processing in Fragile X-associated tremor/ataxia syndrome Cell Reports  2013 3:869-880  DOI:10.1016/j.celrep.2013.02.004  PMID:23478018  PMCID:PMC3639429
    • Guan, L. R., Disney, M. D. Small-molecule-mediated cleavage of RNA in living cells Angewandte Chemie-International Edition  2013 52:1462-1465  DOI:10.1002/anie.201206888  PMID:23280953  PMCID:PMC3711026
    • Childs-Disney, J. L., Parkesh, R., Nakamori, M., Thornton, C. A., Disney, M. D. Rational design of bioactive, modularly assembled aminoglycosides targeting the RNA that causes myotonic dystrophy type 1 ACS Chemical Biology  2012 7:1984-1993  DOI:10.1021/cb3001606  PMID:23130637  PMCID:PMC3528830
    • Velagapudi, S. P., Pushechnikov, A., Labuda, L. P., French, J. M., Disney, M. D. Probing a 2-aminobenzimidazole library for binding to RNA internal loops via two-dimensional combinatorial screening ACS Chemical Biology  2012 7:1902-1909  DOI:10.1021/cb300213g  PMID:22958065  PMCID:PMC3500435
    • Disney, M. D., Liu, B., Yang, W. Y., Sellier, C., Tran, T., Charlet-Berguerand, N., Childs-Disney, J. L. A small molecule that targets r(CGG)(exp) and improves defects in fragile X-associated tremor ataxia syndrome ACS Chemical Biology  2012 7:1711-1718  DOI:10.1021/cb300135h  PMID:22948243  PMCID:PMC3477254
    • Childs-Disney, J. L., Hoskins, J., Rzuczek, S. G., Thornton, C. A., Disney, M. D. Rationally designed small molecules targeting the RNA that causes myotonic dystrophy type 1 are potently bioactive ACS Chemical Biology  2012 7:856-862  DOI:10.1021/cb200408a  PMID:22332923  PMCID:PMC3356481
    • Parkesh, R., Childs-Disney, J. L., Nakamori, M., Kumar, A., Wang, E., Wang, T., Hoskins, J., Tran, T., Housman, D., Thornton, C. A., Disney, M. D. Design of a bioactive small molecule that targets the myotonic dystrophy type 1 RNA via an RNA motif-ligand database and chemical similarity searching Journal of the American Chemical Society  2012 134:4731-4742  DOI:10.1021/ja210088v  PMID:22300544  PMCID:PMC3306011
    • Kumar, A., Parkesh, R., Sznajder, L. J., Childs-Disney, J. L., Sobczak, K., Disney, M. D. Chemical correction of pre-mRNA splicing defects associated with sequestration of muscleblind-like 1 protein by expanded r(CAG)-containing transcripts ACS Chemical Biology  2012 7:496-505  DOI:10.1021/cb200413a  PMID:22252896  PMCID:PMC3306454
    • Guan, L. R., Disney, M. D. Recent advances in developing small molecules targeting RNA ACS Chemical Biology  2012 7:73-86  DOI:10.1021/cb200447r  PMID:22185671
    • Disney, M. D. Studying modification of aminoglycoside antibiotics by resistance-causing enzymes via microarray Methods in Molecular Biology  2012 808:303-320  DOI:10.1007/978-1-61779-373-8_21  PMID:22057534  PMCID:PMC3809005
    • Kumar, A., Park, H., Fang, P. F., Parkesh, R., Guo, M., Nettles, K. W., Disney, M. D. Myotonic dystrophy type 1 RNA crystal structures reveal heterogeneous 1 x 1 nucleotide UU internal loop conformations Biochemistry  2011 50:9928-9935  DOI:10.1021/bi2013068  PMID:21988728  PMCID:PMC3218087
    • Kumar, A., Fang, P. F., Park, H., Guo, M., Nettles, K. W., Disney, M. D. A crystal structure of a model of the repeating r(CGG) transcript found in fragile X syndrome ChemBioChem  2011 12:2140-2142  DOI:10.1002/cbic.201100337  PMID:21766409  PMCID:PMC3379549
    • Childs-Disney, J. L., Tsitovich, P. B., Disney, M. D. Using modularly assembled ligands to bind RNA internal loops separated by different distances ChemBioChem  2011 12:2143-2146  DOI:10.1002/cbic.201100298  PMID:21830289  PMCID:PMC3378996
    • Velagapudi, S. P., Seedhouse, S. J., French, J., Disney, M. D. Defining the rna internal loops preferred by benzimidazole derivatives via 2D combinatorial screening and computational analysis Journal of the American Chemical Society  2011 133:10111-10118  DOI:10.1021/ja200212b  PMID:21604752  PMCID:PMC3126894
    • Tran, T., Disney, M. D. Molecular recognition of 6 '-N-5-hexynoate kanamycin A and RNA 1x1 internal loops containing CA mismatches Biochemistry  2011 50:962-969  DOI:10.1021/bi101724h  PMID:21207945  PMCID:PMC3106427
    • Parkesh, R., Fountain, M., Disney, M. D. NMR spectroscopy and molecular dynamics simulation of r(CCGCUGCGG)(2) reveal a dynamic UU internal loop found in myotonic dystrophy type 1 Biochemistry  2011 50:599-601  DOI:10.1021/bi101896j  PMID:21204525  PMCID:PMC3031998
    • Lee, M. M., French, J. M., Disney, M. D. Influencing uptake and localization of aminoglycoside-functionalized peptoids Molecular Biosystems  2011 7:2441-2451  DOI:10.1039/c1mb05074e  PMID:21611644  PMCID:PMC3135690
    • Tsitovich, P. B., Pushechnikov, A., French, J. M., Disney, M. D. A chemoenzymatic route to diversify aminolgycosides enables a microarray-based method to probe acetyltransferase activity ChemBioChem  2010 11:1656-1660  DOI:10.1002/cbic.201000300  PMID:20629012  PMCID:PMC3016878
    • Tran, T., Disney, M. D. Two-dimensional combinatorial screening of a bacterial rRNA A-site-like motif library: defining privileged asymmetric internal loops that bind aminoglycosides Biochemistry  2010 49:1833-1842  DOI:10.1021/bi901998m  PMID:20108982  PMCID:PMC2846769
    • Seedhouse, S. J., Labuda, L. P., Disney, M. D. The privileged chemical space predictor (PCSP): A computer program that identifies privileged chemical space from screens of modularly assembled chemical libraries Bioorganic & Medicinal Chemistry Letters  2010 20:1338-1343  DOI:10.1016/j.bmcl.2010.01.017  PMID:20097562  PMCID:PMC2825671
    • Disney, M. D., Lee, M. M., Pushechnikov, A., Childs-Disney, J. L. The role of flexibility in the rational design of modularly assembled ligands targeting the RNAs that cause the myotonic dystrophies ChemBioChem  2010 11:375-382  DOI:10.1002/cbic.200900716  PMID:20058255  PMCID:PMC2848078
    • Velagapudi, S. P., Seedhouse, S. J., Disney, M. D. Structure-activity relationships through sequencing (stARTS) defines optimal and suboptimal RNA motif targets for small molecules Angewandte Chemie-International Edition  2010 49:3816-3818  DOI:10.1002/anie.200907257  PMID:20397174  PMCID:PMC3021749
    • Lee, M. M., Childs-Disney, J. L., Pushechnikov, A., French, J. M., Sobczak, K., Thornton, C. A., Disney, M. D. Controlling the specificity of modularly assembled small molecules for RNA via ligand module spacing: Targeting the RNAs that cause myotonic muscular dystrophy Journal of the American Chemical Society  2009 131:17464-17472  DOI:10.1021/ja906877y  PMID:19904940  PMCID:PMC2801143
    • Paul, D. J., Seedhouse, S. J., Disney, M. D. Two-dimensional combinatorial screening and the RNA Privileged Space Predictor program efficiently identify aminoglycoside-RNA hairpin loop interactions Nucleic Acids Research  2009 37:5894-5907  DOI:10.1093/nar/gkp594  PMID:19726586  PMCID:PMC2761267
    • Pushechnikov, A., Lee, M. M., Childs-Disney, J. L., Sobczak, K., French, J. M., Thornton, C. A., Disney, M. D. Rational design of ligands targeting triplet repeating transcripts that cause RNA dominant disease: Application to myotonic muscular dystrophy type 1 and spinocerebellar ataxia type 3 Journal of the American Chemical Society  2009 131:9767-9779  DOI:10.1021/ja9020149  PMID:19552411  PMCID:PMC2731475
    • Lee, M. M., Pushechnikov, A., Disney, M. D. Rational and modular design of potent ligands targeting the rna that causes myotonic dystrophy 2 ACS Chemical Biology  2009 4:345-355  DOI:10.1021/cb900025w  PMID:19348464  PMCID:PMC2748256
    • Labuda, L. P., Pushechnikov, A., Disney, M. D. Small molecule microarrays of RNA-focused peptoids help identify inhibitors of a pathogenic group I intron ACS Chemical Biology  2009 4:299-307  DOI:10.1021/cb800313m  PMID:19278238  PMCID:PMC2777746
    • Aminova, O., Paul, D. J., Childs-Disney, J. L., Disney, M. D. Two-dimensional combinatorial screening identifies specific 6 '-acylated kanamycin A- and 6 '-acylated neamine-RNA hairpin interactions Biochemistry  2008 47:12670-12679  DOI:10.1021/bi8012615  PMID:18991404  PMCID:PMC2681321
    • Barrett, O. J., Pushechnikov, A., Wu, M. L., Disney, M. D. Studying aminoglycoside modification by the acetyltransferase class of resistance-causing enzymes via microarray Carbohydrate Research  2008 343:2924-2931  DOI:10.1016/j.carres.2008.08.018  PMID:18774127  PMCID:PMC2783256
    • Disney, M. D., Labuda, L. P., Paul, D. J., Poplawski, S. G., Pushechnikov, A., Tran, T., Velagapudi, S. P., Wu, M., Childs-Disney, J. L. Two-dimensional combinatorial screening identifies specific aminoglycoside - RNA internal loop partners Journal of the American Chemical Society  2008 130:11185-11194  DOI:10.1021/ja803234t  PMID:18652457
    • Childs-Disney, J. L., Disney, M. D. A simple ligation-based method to increase the information density in sequencing reactions used to deconvolute nucleic acid selections RNA-a Publication of the RNA Society  2008 14:390-394  DOI:10.1261/ma.576908  PMID:18065718  PMCID:PMC2212251
    • Childs-Disney, J. L., Wu, M. L., Pushechnikov, A., Aminova, O., Disney, M. D. A small molecule microarray platform to select RNA internal loop-ligand interactions ACS Chemical Biology  2007 2:745-754  DOI:10.1021/6700174r  PMID:17975888
    • Disney, M. D., Barrett, O. J. An aminoglycoside microarray platform for directly monitoring and studying antibiotic resistance Biochemistry  2007 46:11223-11230  DOI:10.1021/bi701071h  PMID:17867707
    • Disney, M. D., Childs-Disney, J. L. Using selection to identify and chemical microarray to study the rna internal loops recognized by 6 '-n-acylated kanamycin a ChemBioChem  2007 8:649-656  DOI:10.1002/cbic.200600569  PMID:17394189
    • Barrett, O. J., Childs, J. L., Disney, M. D. Chemical microarrays to identify ligands that bind pathogenic cells ChemBioChem  2006 7:1882-1885  DOI:10.1002/cbic.200600260  PMID:17009274
    • Brun, M. A., Disney, M. D., Seeberger, P. H. Miniaturization of microwave-assisted carbohydrate functionalization to create oligosaccharide microarrays ChemBioChem  2006 7:421-424  DOI:10.1002/cbic.200500361  PMID:16444768
    • Kehr, J. C., Zilliges, Y., Springer, A., Disney, M. D., Ratner, D. D., Bouchier, C., Seeberger, P. H., de Marsac, N. T., Dittmann, E. A mannan binding lectin is involved in cell-cell attachment in a toxic strain of Microcystis aeruginosa Molecular Microbiology  2006 59:893-906  DOI:10.1111/j.1365-2958.2005.05001.x  PMID:16420359
    • Disney, M. D., Stephenson, R., Wright, T. W., Haidaris, C. G., Turner, D. H., Gigliotti, F. Activity of hoechst 33258 against Pneumocystis carinii f. sp muris, Candida albicans, and Candida dubliniensis Antimicrobial Agents and Chemotherapy  2005 49:1326-1330  DOI:10.1128/aac.49.4.1326-1330.2005  PMID:15793106
    • Disney, M. D., Hook, D. F., Namoto, K., Seeberger, P. H., Seebach, D. N-linked glycosylated β-peptides are resistant to degradation by glycoamidase A Chemistry & Biodiversity  2005 2:1624-1634  DOI:10.1002/cbdv.200590132  PMID:17191959
    • Disney, M. D., Childs, J. L., Turner, D. H. Hoechst 33258 selectively inhibits group I intron self-splicing by affecting RNA folding ChemBioChem  2004 5:1647-1652  DOI:10.1002/cbic.200400159  PMID:15532034
    • Disney, M. D., Seeberger, P. H. The use of carbohydrate microarrays to study carbohydrate-cell interactions and to detect pathogens Chemistry & Biology  2004 11:1701-1707  DOI:10.1016/j.chembiol.2004.10.011  PMID:15610854
    • Disney, M. D., Zheng, J., Swager, T. M., Seeberger, P. H. Detection of bacteria with carbohydrate-functionalized fluorescent polymers Journal of the American Chemical Society  2004 126:13343-13346  DOI:10.1021/ja047936i  PMID:15479090
    • Ratner, D. M., Adams, E. W., Disney, M. D., Seeberger, P. H. Tools for glycomics: mapping interactions of carbohydrates in biological systems ChemBioChem  2004 5:1375-1383  DOI:10.1002/cbic.200400106  PMID:15457538
    • Disney, M. D., Seeberger, P. H. Aminoglycoside microarrays to explore interactions of antibiotics with RNAs and proteins Chemistry-a European Journal  2004 10:3308-3314  DOI:10.1002/chem.200306017  PMID:15224340
    • Mathews, D. H., Disney, M. D., Childs, J. L., Schroeder, S. J., Zuker, M., Turner, D. H. Incorporating chemical modification constraints into a dynamic programming algorithm for prediction of RNA secondary structure Proceedings of the National Academy of Sciences of the United States of America  2004 101:7287-7292  DOI:10.1073/pnas.0401799101  PMID:15123812  PMCID:PMC409911
    • Disney, M. D., Magnet, S., Blanchard, J. S., Seeberger, P. H. Aminoglycoside microarrays to study antibiotic resistance Angewandte Chemie-International Edition  2004 43:1591-1594  DOI:10.1002/anie.200353236  PMID:15022242
    • Disney, M. D., Childs, J. L., Turner, D. H. New approaches to targeting RNA with oligonucleotides: inhibition of group I intron self-splicing Biopolymers  2004 73:151-161  DOI:10.1002/bip.10520  PMID:14691946
    • Du, H., Disney, M. D., Miller, B. L., Krauss, T. D. Hybridization-based unquenching of DNA hairpins on au surfaces: prototypical "molecular beacon" biosensors Journal of the American Chemical Society  2003 125:4012-4013  DOI:10.1021/ja0290781  PMID:12670198
    • Disney, M. D., Haidaris, C. G., Turner, D. H. Uptake and antifungal activity of oligonucleotides in Candida albicans Proceedings of the National Academy of Sciences of the United States of America  2003 100:1530-1534  DOI:10.1073/pnas.0337462100  PMID:12552085  PMCID:PMC149866
    • Childs, J. L., Disney, M. D., Turner, D. H. Oligonucleotide directed misfolding of RNA inhibits Candida albicans group I intron splicing Proceedings of the National Academy of Sciences of the United States of America  2002 99:11091-11096  DOI:10.1073/pnas.172391199  PMID:12169671  PMCID:PMC123215
    • Disney, M. D., Turner, D. H. Molecular recognition by the Candida albicans group I intron: tertiary interactions with an imino G.A pair facilitate binding of the 5' exon and lower the KM for guanosine Biochemistry  2002 41:8113-8119  DOI:10.1021/bi020102x  PMID:12069604
    • Disney, M. D., Matray, T., Gryaznov, S. M., Turner, D. H. Binding enhancement by tertiary interactions and suicide inhibition of a Candida albicans group I intron by phosphoramidate and 2 '-o-methyl hexanucleotides Biochemistry  2001 40:6520-6526  DOI:10.1021/bi002009j  PMID:11371215
    • Disney, M. D., Haidaris, C. G., Turner, D. H. Recognition elements for 5 ' exon substrate binding to the Candida albicans group I intron Biochemistry  2001 40:6507-6519  DOI:10.1021/bi002008r  PMID:11371214
    • Disney, M. D., Gryaznov, S. M., Turner, D. H. Contributions of individual nucleotides to tertiary binding of substrate by a Pneumocystis carinii group I intron Biochemistry  2000 39:14269-14278  DOI:10.1021/bi001345x  PMID:11087376
    • Disney, M. D., Testa, S. M., Turner, D. H. Targeting a pneumocystis carinii group i intron with methylphosphonate oligonucleotides: Backbone charge is not required for binding or reactivity Biochemistry  2000 39:6991-7000  DOI:10.1021/bi992937m  PMID:10841781
    • Testa, S. M., Disney, M. D., Turner, D. H., Kierzek, R. Thermodynamics of RNA-RNA duplexes with 2-or 4-thiouridines: implications for antisense design and targeting a group I intron Biochemistry  1999 38:16655-16662  DOI:10.1021/bi991187d  PMID:10600128
  • chapter

    • Childs-Disney, J. L., Disney, M. D. Approaches to validate and manipulate RNA targets with small molecules in cells Annual Review of Pharmacology and Toxicology. 123-140. 2016  DOI:10.1146/annurev-pharmtox-010715-103910  PMID:26514201  PMCID:PMC4876813

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Research

research overview

  • The Disney laboratory develops rational methods to target RNA with small molecules.

    Specific areas of interest are:

    • Developing computational tools to target RNAs from sequence.

    • Using multi-dimensional combinatorial screening (libraries of libraries) to understand the chemical space (small molecule ligands) that is privileged for binding to RNA targets and the RNA structure space that is privileged for binding to small molecules.

    • Rational design of small molecules targeting triplet repeating RNAs. Focus in this area is currently on targeting the RNAs that cause myotonic dystrophy types 1 and 2, which are type of muscular dystrophy that currently have no treatment.

    • Structural biology of RNA: understanding the interplay of RNA structure and small molecule recognition of those structures.

    • Rational design of novel antibacterials that target the bacterial ribosome and evade known modes of resistance.

    • Synthetic organic chemistry: design and synthesis of small molecule libraries that are focused for binding RNA and in developing chemo-enzymatic routes to enable the synthesis of un-natural carbohydrates.
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Teaching

advisees

  • graduate advising relationship

    • Angelbello, Alicia, Ph.D.  candidate, 2016 -
    • Bush, Jessica Anne, Ph.D.  candidate, 2019 -
    • Haniff, Hafeez, Ph.D.  candidate, 2015 -
    • Suresh, Blessy, Ph.D.  candidate, 2018 -
    • Zhang, Peiyuan, Ph.D.  candidate, 2017 -
    • Costales, Matthew Guese, Ph.D.  candidate, 2015 - 2019
    • Wilson, Henry, Ph.D.  candidate, 2014 - 2019
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Background

education and training

  • Ph.D. in Biophysical Chemistry, University of Rochester 2003
  • M.S. in Chemistry, University of Rochester 1999
  • B.S. in Chemistry, University of Maryland, College Park , with Honors 1997

awards and honors

  • Raymond and Beverly Sackler Prize in the Physical Sciences in the field of Chemistry/Chemical Biology, 2019
  • Blavatnik National Award Finalist, conferred by The Blavatnik Family Foundation, 2016
  • NIH Director's Pioneer Award, conferred by National Institutes of Health, 2015
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Contact

full name

  • Matthew David Disney

geographic location

  • Scripps Florida 

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