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Dickerson, Tobin
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Dickerson, Tobin

Graduate Student
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Positions

  • 2012 - 2019 Associate Professor, Chemistry , Scripps Research
  • 2012 - 2019 Associate Professor (Joint Appointment), The Worm Institute for Research and Medicine (WIRM) , Scripps Research
  • 2005 - 2019 Faculty Member, Skaggs Graduate School of Chemical and Biological Sciences , Scripps Research
  • 2005 - 2012 Assistant Professor, Chemistry , Scripps Research
  • 2005 - 2012 Assistant Professor (Joint Appointment), The Worm Institute for Research and Medicine (WIRM) , Scripps Research
  • 2008 - 2010 Founder and Chair, Scientific Advisory Board, Lake Sherwood Sorrento Partners, LLC
  • 2004 - 2005 Senior Research Associate, Scripps Research
  • 2004 - 2005 Senior Research Associate, The Worm Institute for Research and Medicine (WIRM) , Scripps Research
Dr. Tobin Dickerson develops biochemical technologies for predicting and treating evolving disease such as influenza, hepatitis C, and cancer, high-throughput screening paradigms for protein-ligand agonists/antagonists, combating filarial parasites, and the modulation of botulinum neurotoxin.

Research Areas research areas

  • Addiction (UMLS)
  • Blindness (UMLS)
  • Botulinum Neurotoxin (UMLS)
  • Cancer (UMLS)
  • Neglected Tropical Diseases & Tuberculosis

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Publications

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    • Javadi-Paydar, M., Harvey, E. L., Grant, Y., Vandewater, S. A., Creehan, K. M., Nguyen, J. D., Dickerson, T. J., Taffe, M. A. Binge-like acquisition of α-pyrrolidinopentiophenone (α-PVP) self-administration in female rats Psychopharmacology  2018 235:2447-2457  DOI:10.1007/s00213-018-4943-3  PMID:29909425
    • Javadi-Paydar, M., Nguyen, J. D., Vandewater, S. A., Dickerson, T. J., Taffe, M. A. Locomotor and reinforcing effects of pentedrone, pentylone and methylone in rats Neuropharmacology  2018 134:57-64  DOI:10.1016/j.neuropharm.2017.09.002  PMID:28882561  PMCID:PMC5835165
    • Bompiani, K. M., Caglic, D., Krutein, M. C., Benoni, G., Hrones, M., Lairson, L. L., Bian, H. Y., Smith, G. R., Dickerson, T. J. High-Throughput Screening Uncovers Novel Botulinum Neurotoxin Inhibitor Chemotypes ACS Combinatorial Science  2016 18:461-474  DOI:10.1021/acscombsci.6b00033  PMID:27314875
    • Aarde, S. M., Huang, P. K., Dickerson, T. J., Taffe, M. Binge-like acquisition of 3,4-methylenedioxypyrovalerone (MDPV) self-administration and wheel activity in rats Psychopharmacology  2015 232:1867-1877  DOI:10.1007/s00213-014-3819-4  PMID:25424056  PMCID:PMC4426253
    • Aarde, S. M., Creehan, K. M., Vandewater, S. A., Dickerson, T. J., Taffe, M. A. In vivo potency and efficacy of the novel cathinone α-pyrrolidinopentiophenone and 3,4-methylenedioxypyrovalerone: self-administration and locomotor stimulation in male rats Psychopharmacology  2015 232:3045-3055  DOI:10.1007/s00213-015-3944-8  PMID:25925780  PMCID:PMC4515201
    • Dickerson, T. J., Smith, G. R., Pelletier, J. C., Reitz, A. B. 8-Hydroxyquinoline and hydroxamic acid inhibitors of botulinum neurotoxin BoNT/A Current Topics in Medicinal Chemistry  2014 14:2094-2102  PMID:25335884
    • Sakamuri, R. M., Capek, P., Dickerson, T. J., Barry III, C. E., Mukundan, H., Swanson, B. I. Detection of stealthy small amphiphilic biomarkers Journal of Microbiological Methods  2014 103:112-117  DOI:10.1016/j.mimet.2014.05.012  PMID:24880131
    • Bompiani, K. M., Dickerson, T. J. High-throughput screening technologies for botulinum neurotoxins Current Topics in Medicinal Chemistry  2014 14:2062-2080  PMID:25335886
    • Caglic, D., Krutein, M. C., Bompiani, K. M., Barlow, D. J., Benoni, G., Pelletier, J. C., Reitz, A. B., Lairson, L. L., Houseknecht, K. L., Smith, G. R., Dickerson, T. J. Identification of clinically viable quinolinol inhibitors of botulinum neurotoxin A light chain Journal of Medicinal Chemistry  2014 57:669-676  DOI:10.1021/jm4012164  PMID:24387280  PMCID:PMC3983388
    • Dickerson, T. J., Smith, G. R., Reitz, A. B. Inhibition of botulinum neurotoxin BoNT/A Current Topics in Medicinal Chemistry  2014 14:2043-2043  PMID:25335883
    • Rodriguez, L. P., Vilarino, N., Louzao, M. C., Dickerson, T. J., Nicolaou, K. C., Frederick, M. O., Botana, L. M. Microsphere-based immunoassay for the detection of azaspiracids Analytical Biochemistry  2014 447:58-63  DOI:10.1016/j.ab.2013.10.035  PMID:24215909  PMCID:PMC3947218
    • Caglic, D., Bompiani, K. M., Krutein, M. C., Capek, P., Dickerson, T. J. A high-throughput-compatible FRET-based platform for identification and characterization of botulinum neurotoxin light chain modulators Journal of Visualized Experiments : JoVE  2013 50908  DOI:10.3791/50908  PMID:24430674  PMCID:PMC4107797
    • Miller, M. L., Creehan, K. M., Angrish, D., Barlow, D. J., Houseknecht, K. L., Dickerson, T. J., Taffe, M. A. Changes in ambient temperature differentially alter the thermoregulatory, cardiac and locomotor stimulant effects of 4-methylmethcathinone (mephedrone) Drug and Alcohol Dependence  2013 127:248-253  DOI:10.1016/j.drugalcdep.2012.07.003  PMID:22832282  PMCID:PMC3491086
    • Aarde, S. M., Angrish, D., Barlow, D. J., Wright, M. J., Vandewater, S. A., Creehan, K. M., Houseknecht, K. L., Dickerson, T. J., Taffe, M. A. Mephedrone (4-methylmethcathinone) supports intravenous self-administration in Sprague-Dawley and Wistar rats Addiction Biology  2013 18:786-799  DOI:10.1111/adb.12038  PMID:23363010  PMCID:PMC3641159
    • Aarde, S. M., Angrish, D., Barlow, D. J., Wright Jr, M. J., Vandewater, S. A., Creehan, K. M., Houseknecht, K. L., Dickerson, T. J., Taffe, M. A. Mephedrone (4-methylmethcathinone) supports intravenous self-administration in sprague-dawley and wistar rats Addiction Biology  2013  DOI:10.1111/adb.12038  PMID:23363010  PMCID:PMC3641159
    • Aarde, S. M., Huang, P. K., Creehan, K. M., Dickerson, T. J., Taffe, M. A. The novel recreational drug 3,4-methylenedioxypyrovalerone (MDPV) is a potent psychomotor stimulant: Self-administration and locomotor activity in rats Neuropharmacology  2013 71:130-140  DOI:10.1016/j.neuropharm.2013.04.003  PMID:23597511  PMCID:PMC3681807
    • Caglic, D., Dickerson, T. J. A coincidence detector triggers botulinum neurotoxin translocation Future Microbiology  2012 7:185-188  DOI:10.2217/fmb.11.157  PMID:22324987  PMCID:PMC3637022
    • Huang, P. K., Aarde, S. M., Angrish, D., Houseknecht, K. L., Dickerson, T. J., Taffe, M. A. Contrasting effects of d-methamphetamine, 3,4-methylenedioxymethamphetamine, 3,4-methylenedioxypyrovalerone, and 4-methylmethcathinone on wheel activity in rats Drug and Alcohol Dependence  2012 126:168-175  DOI:10.1016/j.drugalcdep.2012.05.011  PMID:22664136  PMCID:PMC3439532
    • Wright, M. J., Angrish, D., Aarde, S. M., Barlow, D. J., Buczynski, M. W., Creehan, K. M., Vandewater, S. A., Parsons, L. H., Houseknecht, K. L., Dickerson, T. J., Taffe, M. A. Effect of ambient temperature on the thermoregulatory and locomotor stimulant effects of 4-methylmethcathinone in Wistar and Sprague-Dawley rats PLoS One  2012 7:e44652  DOI:10.1371/journal.pone.0044652  PMID:22952999  PMCID:PMC3432134
    • Wright, M. J., Vandewater, S. A., Angrish, D., Dickerson, T. J., Taffe, M. A. Mephedrone (4-methylmethcathinone) and d-methamphetamine improve visuospatial associative memory, but not spatial working memory, in rhesus macaques British Journal of Pharmacology  2012 167:1342-1352  DOI:10.1111/j.1476-5381.2012.02091.x  PMID:22748013  PMCID:PMC3504998
    • Smith, G. R., Caglic, D., Capek, P., Zhang, Y., Godbole, S., Reitz, A. B., Dickerson, T. J. Reexamining hydroxamate inhibitors of botulinum neurotoxin serotype a: Extending towards the beta-exosite Bioorganic & Medicinal Chemistry Letters  2012 22:3754-3757  DOI:10.1016/j.bmcl.2012.04.019  PMID:22542019  PMCID:PMC3352981
    • Denery, J. R., Nunes, A. A. K., Dickerson, T. J. Characterization of differences between blood sample matrices in untargeted metabolomics Analytical Chemistry  2011 83:1040-1047  DOI:10.1021/ac102806p  PMID:21175165
    • Capek, P., Zhang, Y., Barlow, D. J., Houseknecht, K. L., Smith, G. R., Dickerson, T. J. Enhancing the pharmacokinetic properties of botulinum neurotoxin serotype a protease inhibitors through rational design ACS Chemical Neuroscience  2011 2:288-293  DOI:10.1021/cn200021q  PMID:21743830  PMCID:PMC3129992
    • Capek, P., Kirkconnell, K. S., Dickerson, T. J. A bacteriophage-based platform for rapid trace detection of proteases Journal of the American Chemical Society  2010 132:13126-13128  DOI:10.1021/ja104572f  PMID:20812737  PMCID:PMC2949351
    • Moreno, A. Y., Azar, M. R., Warren, N. A., Dickerson, T. J., Koob, G. F., Janda, K. D. A critical evaluation of a nicotine vaccine within a self-administration behavioral model Molecular Pharmaceutics  2010 7:431-441  DOI:10.1021/mp900213u  PMID:20104903
    • Denery, J. R., Nunes, A. A. K., Hixon, M. S., Dickerson, T. J., Janda, K. D. Metabolomics-based discovery of diagnostic biomarkers for onchocerciasis PLoS Neglected Tropical Diseases  2010 4:e834  DOI:10.1371/journal.pntd.0000834  PMID:20957145  PMCID:PMC2950146
    • Janda, K. D., Fischer, A., Tepp, W. H., Eubanks, L. M., Clancy, C. M., Montal, M., Pellett, S., Johnson, E. A., Dickerson, T. J., Nakai, Y. Bimodal modulation of the botulinum neurotoxin protein-conducting channel Proceedings of the National Academy of Sciences of the United States of America  2009 106:1330-1335  DOI:10.1073/pnas.0812839106  PMID:19164566  PMCID:PMC2635780
    • Treweek, J. B., Dickerson, T. J., Janda, K. D. Drugs of abuse that mediate advanced glycation end product formation: A chemical link to disease pathology Accounts of Chemical Research  2009 42:659-669  DOI:10.1021/ar800247d  PMID:19275211  PMCID:PMC2982794
    • Dickerson, T. J., Janda, K. D., Tepp, W. H., Nakai, Y., Johnson, E. A. Function-oriented synthesis applied to the anti-botulinum natural product toosendanin Bioorganic & Medicinal Chemistry  2009 17:1152-1157  DOI:10.1016/j.bmc.2008.12.042  PMID:19131252  PMCID:PMC2661763
    • Frederick, M. O., Marin, S. D., Janda, K. D., Nicolaou, K. C., Dickerson, T. J. Monoclonal antibodies with orthogonal azaspiracid epitopes ChemBioChem  2009 10:1625-1629  DOI:10.1002/cbic.200900201  PMID:19492388  PMCID:PMC2750835
    • Rohrbach, A. S., Dickerson, T. J. Predicting protein evolution in vitro by phage escape technology Molecular Biosystems  2009 5:128-133  DOI:10.1039/b814768j  PMID:19156257
    • Willis, B., Eubanks, L. M., Wood, M. R., Janda, K. D., Dickerson, T. J., Lerner, R. A. Biologically templated organic polymers with nanoscale order Proceedings of the National Academy of Sciences of the United States of America  2008 105:1416-1419  DOI:10.1073/pnas.0711308105  PMID:18216240  PMCID:PMC2234158
    • Lowery, C. A., Dickerson, T. J., Janda, K. D. Interspecies and interkingdom communication mediated by bacterial quorum sensing Chemical Society Reviews  2008 37:1337-1346  DOI:10.1039/b702781h  PMID:18568160
    • Park, J., Dickerson, T. J., Janda, K. D. Major sperm protein as a diagnostic antigen for onchocerciasis Bioorganic & Medicinal Chemistry  2008 16:7206-7209  DOI:10.1016/j.bmc.2008.06.038  PMID:18632276
    • Treweek, J. B., Sun, C., Mayorov, A. V., Qi, L., Levy, C. L., Roberts, A. J., Dickerson, T. J., Janda, K. D. Prevention of drug-induced memory impairment by immunopharmacotherapy Journal of Medicinal Chemistry  2008 51:6866-6875  DOI:10.1021/jm800506v  PMID:18921991  PMCID:PMC2661766
    • Willis, B., Eubanks, L. M., Dickerson, T. J., Janda, K. D. The strange case of the botulinum neurotoxin: Using chemistry and bilogy to modulate the most deadly poison Angewandte Chemie-International Edition  2008 47:8360-8379  DOI:10.1002/anie.200705531  PMID:18844202
    • Dickerson, T. J., Clancy, C. M., Johnson, E. A., Baldwin, M. R., Jin, W., Barbieri, J. T., Tepp, W. H., Eubanks, L. M., Malizio, C. J., Goodnough, M. C., Janda, K. D., Hong, S., et al. An in vitro and in vivo disconnect uncovered through high-throughput identification of botulinum neurotoxin A antagonists Proceedings of the National Academy of Sciences of the United States of America  2007 104:2602-2607  DOI:10.1073/pnas.0611213104  PMID:17293454  PMCID:PMC1815229
    • Brogan, A. P., Eubanks, L. M., Koob, G. F., Dickerson, T. J., Janda, K. D. Antibody-catalyzed oxidation of delta(9)-tetrahydrocannabinol Journal of the American Chemical Society  2007 129:3698-3702  DOI:10.1021/ja070022m  PMID:17335216
    • Eubanks, L. M., Dickerson, T. J. Investigating novel therapeutic targets and molecular mechanisms to treat botulinum neurotoxin a intoxication Future Microbiology  2007 2:677-687  DOI:10.2217/17460913.2.6.677  PMID:18041908
    • Yao, Y., Dickerson, T. J., Hixon, M. S., Dyson, H. J. Nmr detection of adventitious xylose binding to the quorum-sensing protein SdiA of Escherichia coli Bioorganic & Medicinal Chemistry Letters  2007 17:6202-6205  DOI:10.1016/j.bmc1.2007.09.029  PMID:17889538
    • Brogan, A. P., Dickerson, T. J., Janda, K. D. Noirnicotine-organocatalyzed aqueous reduction of alpha,beta-unsaturated aldehydes Chemical Communications  2007 4952-4954  DOI:10.1039/b713273e  PMID:18361380
    • Dickerson, T. J., McKenzie, K. M., Hoyt, A. S., Wood, M. R., Janda, K. D., Brenner, S. B., Lerner, R. A. Phage escape libraries for checkmate analysis Proceedings of the National Academy of Sciences of the United States of America  2007 104:12703-12708  DOI:10.1073/pnas.0705362104  PMID:17646645  PMCID:PMC1937530
    • Ino, A., Dickerson, T. J., Janda, K. D. Positional linker effects in haptens for cocaine immunopharmacotherapy Bioorganic & Medicinal Chemistry Letters  2007 17:4280-4283  DOI:10.1016/j.bmcl.2007.05.032  PMID:17531484
    • Treweek, J., Wee, S., Koob, G. F., Dickerson, T. J., Janda, K. D. Self-vaccination by methamphetamine glycation products chemically links chronic drug abuse and cardiovascular disease Proceedings of the National Academy of Sciences of the United States of America  2007 104:11580-11584  DOI:10.1073/pnas.0701328104  PMID:17592122  PMCID:PMC1913859
    • Capkova, K., Yoneda, Y., Dickerson, T. J., Janda, K. D. Synthesis and structure-activity relationships of second-generation hydroxamate botulinum neurotoxin A protease inhibitors Bioorganic & Medicinal Chemistry Letters  2007 17:6463-6466  DOI:10.1016/j.bmcl.2007.09.103  PMID:17951059  PMCID:PMC2170532
    • Eubanks, L. M., Dickerson, T. J., Janda, K. D. Technological advancements for the detection of and protection against biological and chemical warfare agents Chemical Society Reviews  2007 36:458-470  DOI:10.1039/b615227a  PMID:17325785
    • Eubanks, L. M., Rogers, C. J., Beuscher, A. E., Koob, G. F., Olson, A. J., Dickerson, T. J., Janda, K. D. A molecular link between the active component of marijuana and Alzheimer's disease pathology Molecular Pharmaceutics  2006 3:773-777  DOI:10.1021/mp060066m  PMID:17140265  PMCID:PMC2562334
    • Zhu, X. Y., Dickerson, T. J., Rogers, C. J., Kaufmann, G. F., Mee, J. M., McKenzie, K. M., Janda, K. D., Wilson, I. A. Complete reaction cycle of a cocaine catalytic antibody at atomic resolution Structure  2006 14:205-216  DOI:10.1016/j.str.2005.10.014  PMID:16472740
    • Boldt, G. E., Dickerson, T. J., Janda, K. D. Emerging chemical and biological approaches for the preparation of discovery libraries Drug Discovery Today  2006 11:143-148  DOI:10.1016/s1359-6446(05)03697-4  PMID:16533712
    • Rogers, C. J., Dickerson, T. J., Janda, K. D. Kinetic isotope and thermodynamic analysis of the nornicotine-catalyzed aqueous aldol reaction Tetrahedron  2006 62:352-356  DOI:10.1016/j.tet.2005.09.094
    • Yao, Y., Martinez-Yamout, M. A., Dickerson, T. J., Brogan, A. P., Wright, P. E., Dyson, H. J. Structure of the Escherichia coli quorum sensing protein SdiA: Activation of the folding switch by acyl homoserine lactones Journal of Molecular Biology  2006 355:262-273  DOI:10.1016/j.jmb.2005.10.041  PMID:16307757
    • McAllister, L. A., Hixon, M. S., Kennedy, J. P., Dickerson, T. J., Janda, K. D. Superactivation of the botulinum neurotoxin serotype A light chain metalloprotease: A new wrinkle in botulinum neurotoxin Journal of the American Chemical Society  2006 128:4176-4177  DOI:10.1021/ja057699z  PMID:16568962  PMCID:PMC2529174
    • Dickerson, T. J., Janda, K. D. The use of small molecules to investigate molecular mechanisms and therapeutic targets for treatment of botulinum neurotoxin A intoxication ACS Chemical Biology  2006 1:359-369  DOI:10.1021/cb600179d  PMID:17163773
    • Rogers, C. J., Eubanks, L. M., Dickerson, T. J., Janda, K. D. Unexpected acetylcholinesterase activity of cocaine esterases Journal of the American Chemical Society  2006 128:15364-15365  DOI:10.1021/ja066241+  PMID:17131989  PMCID:PMC2533137
    • Rogers, C. J., Dickerson, T. J., Wentworth, P., Janda, K. D. A high-swelling reagent scaffold suitable for use in aqueous and organic solvents Tetrahedron  2005 61:12140-12144  DOI:10.1016/j.tet.2005.07.115
    • Shute, T. S., Matsushita, M., Dickerson, T. J., La Clair, J. J., Janda, K. D., Burkart, M. D. A site-specific bifunctional protein labeling system for affinity and fluorescent analysis Bioconjugate Chemistry  2005 16:1352-1355  DOI:10.1021/bc050213j  PMID:16287229
    • Brogan, A. P., Dickerson, T. J., Boldt, G. E., Janda, K. D. Altered retinoid homeostasis catalyzed by a nicotine metabolite: Implications in macular degenerationand and normal development Proceedings of the National Academy of Sciences of the United States of America  2005 102:10433-10438  DOI:10.1073/pnas.0504721102  PMID:16014706  PMCID:PMC1180800
    • Dickerson, T. J., Kaufmann, G. F., Janda, K. D. Bacteriophage-mediated protein delivery into the central nervous system and its application in immunopharmacotherapy Expert Opinion on Biological Therapy  2005 5:773-781  DOI:10.1517/14712598.5.6.773  PMID:15952908
    • Dickerson, T. J., Beuscher, A. E., Hixon, M. S., Yamamoto, N., Xu, Y., Olson, A. J., Janda, K. D. Discovery of acetylcholinesterase peripheral anionic site ligands through computational refinement of a directed library Biochemistry  2005 44:14845-14853  DOI:10.1021/bi051613x  PMID:16274232
    • Reed, N. N., Dickerson, T. J., Boldt, G. E., Janda, K. D. Enantioreversal in the sharpless asymmetric epoxidation reaction controlled by the molecular weight of a covalently appended achiral polymer Journal of Organic Chemistry  2005 70:1728-1731  DOI:10.1021/jo048009x  PMID:15730294
    • Rogers, C. J., Dickerson, T. J., Brogan, A. P., Janda, K. D. Hammett correlation of nornicotine analogues in the aqueous aldol reaction: Implications for green organocatalysis Journal of Organic Chemistry  2005 70:3705-3708  DOI:10.1021/jo050161r  PMID:15845010
    • Kaufmann, G. F., Sartorio, R., Lee, S. H., Rogers, C. J., Meijler, M. M., Moss, J. A., Clapham, B., Brogan, A. P., Dickerson, T. J., Janda, K. D. Revisiting quorum sensing: Discovery of additional chemical and biological functions for 3-oxo-N-acylhomoserine lactones Proceedings of the National Academy of Sciences of the United States of America  2005 102:309-314  DOI:10.1073/pnas.0408639102  PMID:15623555  PMCID:PMC544315
    • Rogers, C. J., Mee, J. M., Kaufmann, G. F., Dickerson, T. J., Janda, K. D. Toward cocaine esterase therapeutics Journal of the American Chemical Society  2005 127:10016-10017  DOI:10.1021/ja053086a  PMID:16011362  PMCID:PMC1352337
    • Eubanks, L. M., Dickerson, T. J., Janda, K. D. Vitamin B-2-mediated cellular photoinhibition of botulinum neurotoxin A FEBS Letters  2005 579:5361-5364  DOI:10.1016/j.febslet.2005.08.072  PMID:16198354
    • degree-related publication Dickerson, T. J., Reed, N. N., LaClair, J. J., Janda, K. D. A precipitator for the detection of thiophilic metals in aqua Journal of the American Chemical Society  2004 126:16582-16586  DOI:10.1021/ja045798r  PMID:15600364
    • degree-related publication Dickerson, T. J., Yamamoto, N., Janda, K. D. Antibody-catalyzed oxidative degradation of nicotine using riboflavin Bioorganic & Medicinal Chemistry  2004 12:4981-4987  DOI:10.1016/j.bmc.2004.07.006  PMID:15336277
    • degree-related publication Dickerson, T. J., Yamamoto, N., Ruiz, D. I., Janda, K. D. Immunological consequences of methamphetamine protein glycation Journal of the American Chemical Society  2004 126:11446-11447  DOI:10.1021/ja047690h  PMID:15366884
    • degree-related publication Dickerson, T. J., Lovell, T., Meijler, M. M., Noodleman, L., Janda, K. D. Nornicotine aqueous aldol reactions: synthetic and theoretical investigations into the origins of catalysis Journal of Organic Chemistry  2004 69:6603-6609  DOI:10.1021/jo048894j  PMID:15387581
    • degree-related publication Dickerson, T. J., Tremblay, M. R., Hoffman, T. Z., Ruiz, D. I., Janda, K. D. Catalysis of the photo-Fries reaction: Antibody-mediated stabilization of high energy states Journal of the American Chemical Society  2003 125:15395-15401  DOI:10.1021/ja038016n  PMID:14664584
    • degree-related publication Dickerson, T. J., Janda, K. D. Glycation of the amyloid beta-protein by a nicotine metabolite: A fortuitous chemical dynamic between smoking and Alzheimer's disease Proceedings of the National Academy of Sciences of the United States of America  2003 100:8182-8187  DOI:10.1073/pnas.1332847100  PMID:12815102  PMCID:PMC166203
    • degree-related publication Gambs, C., Dickerson, T. J., Mahajan, S., Pasternack, L. B., Janda, K. D. High-resolution diffusion-ordered spectroscopy to probe the microenvironment of JandaJel and Merrifield resins Journal of Organic Chemistry  2003 68:3673-3678  DOI:10.1021/jo034152z  PMID:12713377
    • degree-related publication Dickerson, T. J., Janda, K. D. A previously undescribed chemical link between smoking and metabolic disease Proceedings of the National Academy of Sciences of the United States of America  2002 99:15084-15088  DOI:10.1073/pnas.222561699  PMID:12403823  PMCID:PMC137547
    • degree-related publication Dickerson, T. J., Janda, K. D. Aqueous aldol catalysis by a nicotine metabolite Journal of the American Chemical Society  2002 124:3220-3221  DOI:10.1021/ja017774f  PMID:11916401
    • degree-related publication Moss, J. A., Dickerson, T. J., Janda, K. D. Solid phase peptide synthesis on JandaJel(TM) resin Tetrahedron Letters  2002 43:37-40  DOI:10.1016/s0040-4039(01)02076-7
    • degree-related publication Dickerson, T. J., Reed, N. N., Janda, K. D. Soluble polymers as scaffolds for recoverable catalysts and reagents Chemical Reviews  2002 102:3325-3343  DOI:10.1021/cr010335e  PMID:12371887
    • degree-related publication Tremblay, M. R., Dickerson, T. J., Janda, K. D. Advances in antibody catalysis of cycloaddition reactions Advanced Synthesis & Catalysis  2001 343:577-585  DOI:10.1002/1615-4169(200108)343:6/7<577::aid-adsc577>3.0.co;2-z
    • degree-related publication Dickerson, T. J., Reed, N. N., Janda, K. D. Regio-reactive resin: A platform for orthogonal loading using the polymer backbone and cross-linker Bioorganic & Medicinal Chemistry Letters  2001 11:1507-1509  DOI:10.1016/s0960-894x(01)00152-4  PMID:11412970
  • thesis

    • Physiologically-relevant reactivity of drugs of abuse 2004

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Research

research overview

  • Strategies to Combat Evolving Human Disease

    Our research is broadly focused at the interface of chemical biology, immunology, and medicine with particular interest in the development of technologies that allow questions of biological and clinical relevance to be addressed. A large focus of our work is the generation of methods that recreate in vitro the co-evolution of infectious diseases and the immune system. The technology we have developed, termed phage escape, also can be implemented as a novel high throughput screening method for small molecule protein-ligand antagonists, as well as a single molecule diagnostic platform. Application of these tools to diseases including avian influenza, cancer and neglected tropical diseases (NTDs) are currently underway. We also study the immunological basis of NTDs, including onchocerciasis and lymphatic filariasis, to both treat these diseases as well as apply the mechanisms used by these parasites to modern medicine. An additional focus of our laboratory is aimed at understanding the biochemical mechanism of botulinum neurotoxin, the most lethal protein known and a rapidly expanding clinical tool, with the goal of developing molecules that modulate toxin function.

keywords

  • metabolomics
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Teaching

advisees

  • graduate advising relationship

    • Rohrbach, Amanda, Ph.D.  candidate, 2007 - 2012
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Background

education and training

  • Ph.D. in Chemistry, Scripps Research , with Dr. Kim Janda 2000 - 2004
  • M.A. in Bioorganic Chemistry, University of Virginia 1999 - 2000
  • B.S. in Chemistry, University of Virginia 1995 - 1999

advisee of

  • graduate advising relationship

    • Janda, Kim, Ph.D.  candidacy, 2001 - 2004
  • postdoc or fellow advising relationship

    • Janda, Kim, Ph.D.  candidacy, 2004 - 2005
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Contact

full name

  • Tobin Jarret Dickerson

geographic location

  • Scripps California 

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