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Demko, Zachary
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Demko, Zachary

Graduate Student
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Positions

  • 2011 - Senior Director of Clinical Research, Natera
  • 2011 - Senior Director of Scientific Communications, Natera
  • 2011 - 2014 Senior Director of Research and Deveopment, Natera
  • 2011 - 2014 Senior Director of Intellectual Property, Natera
  • 2010 - 2011 Director of Research and Development, Natera
  • 2006 - 2011 Director of Intellectual Property, Natera
  • 2003 - 2010 Senior Scientist, Synta Pharmaceuticals
  • 2002 - 2003 Scientist I, Pfizer
  • 1996 - 1997 Research Assistant, GlaxoSmithKline
  • 1995 - 1996 Research Assistant, Affymax

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  • Doctoral Dissertation
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Publications

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  • academic article

    • Sigdel, T. K., Archila, F. A., Constantin, T., Prins, S. A., Liberto, J., Damm, I., Towfighi, P., Navarro, S., Kirkizlar, E., Demko, Z. P., Ryan, A., Sigurjonsson, S., et al. Optimizing detection of kidney transplant injury by assessment of donor-derived cell-free DNA via massively multiplex PCR Journal of Clinical Medicine  2019 8  DOI:10.3390/jcm8010019  PMID:30583588  PMCID:PMC6352163
    • Benn, P., Valenti, E., Shah, S., Martin, K., Demko, Z. Factors associated with informative redraw after an initial no result in noninvasive prenatal testing Obstetrics and Gynecology  2018 132:428-435  DOI:10.1097/aog.0000000000002728  PMID:29995728
    • McCoy, R. C., Newnham, L. J., Ottolini, C. S., Hoffmann, E. R., Chatzimeletiou, K., Cornejo, O. E., Zhan, Q., Zaninovic, N., Rosenwaks, Z., Petrov, D. A., Demko, Z. P., Sigurjonsson, S., et al. Tripolar chromosome segregation drives the association between maternal genotype at variants spanning PLK4 and aneuploidy in human preimplantation embryos Human Molecular Genetics  2018 27:2573-2585  DOI:10.1093/hmg/ddy147  PMID:29688390  PMCID:PMC6030883
    • Simon, A. L., Kiehl, M., Fischer, E., Proctor, J. G., Bush, M. R., Givens, C., Rabinowitz, M., Demko, Z. P. Pregnancy outcomes from more than 1,800 in vitro fertilization cycles with the use of 24-chromosome single-nucleotide polymorphism-based preimplantation genetic testing for aneuploidy Fertility and Sterility  2018 110:113-121  DOI:10.1016/j.fertnstert.2018.03.026  PMID:29908770
    • Kort, J. D., McCoy, R. C., Demko, Z., Lathi, R. B. Are blastocyst aneuploidy rates different between fertile and infertile populations? Journal of Assisted Reproduction and Genetics  2018 35:403-408  DOI:10.1007/s10815-017-1060-x  PMID:29063503  PMCID:PMC5904052
    • Ravi, H., McNeill, G., Goel, S., Meltzer, S. D., Hunkapiller, N., Ryan, A., Levy, B., Demko, Z. P. Validation of a SNP-based non-invasive prenatal test to detect the fetal 22q11.2 deletion in maternal plasma samples PLoS One  2018 13:293-300  DOI:10.1371/journal.pone.0193476  PMID:29474437  PMCID:PMC5825123
    • Martin, K., Iyengar, S., Kalyan, A., Lan, C., Simon, A. L., Stosic, M., Kobara, K., Ravi, H., Truong, T., Ryan, A., Demko, Z. P., Benn, P. Clinical experience with a single-nucleotide polymorphism-based non-invasive prenatal test for five clinically significant microdeletions Clinical Genetics  2018 93:293-300  DOI:10.1111/cge.13098  PMID:28696552
    • Benn, P., Iyengar, S., Crowley, T. B., Zackai, E. H., Burrows, E. K., Moshkevich, S., McDonald-McGinn, D. M., Sullivan, K. E., Demko, Z. Pediatric healthcare costs for patients with 22q11.2 deletion syndrome Molecular Genetics & Genomic Medicine  2017 5:631-638  DOI:10.1002/mgg3.310  PMID:29178641
    • Maisenbacher, M. K., Merrion, K., Pettersen, B., Young, M., Paik, K., Iyengar, S., Kareht, S., Sigurjonsson, S., Demko, Z. P., Martin, K. A. Incidence of the 22q11.2 deletion in a large cohort of miscarriage samples Molecular Cytogenetics  2017 10  DOI:10.1186/s13039-017-0308-6  PMID:28293297  PMCID:PMC5345148
    • Samango-Sprouse, C., Kirkizlar, E., Hall, M. P., Lawson, P., Demko, Z., Zneimer, S. M., Curnow, K. J., Gross, S., Gropman, A. Incidence of X and Y chromosomal aneuploidy in a large child bearing population PLoS One  2016 11  DOI:10.1371/journal.pone.0161045  PMID:27512996  PMCID:PMC4981345
    • Demko, Z. P., Simon, A. L., McCoy, R. C., Petrov, D. A., Rabinowitz, M. Effects of maternal age on euploidy rates in a large cohort of embryos analyzed with 24-chromosome single-nucleotide polymorphism-based preimplantation genetic screening Fertility and Sterility  2016 105:1307-1313  DOI:10.1016/j.fertnstert.2016.01.025  PMID:26868992
    • Gross, S. J., Stosic, M., McDonald-McGinn, D. M., Bassett, A. S., Norvez, A., Dhamankar, R., Kobara, K., Kirkizlar, E., Zimmermann, B., Wayham, N., Babiarz, J. E., Ryan, A., et al. Clinical experience with single-nucleotide polymorphism-based non-invasive prenatal screening for 22q11.2 deletion syndrome Ultrasound in Obstetrics & Gynecology  2016 47:177-183  DOI:10.1002/uog.15754  PMID:26396068  PMCID:PMC5064640
    • Ryan, A., Hunkapiller, N., Banjevic, M., Vankayalapati, N., Fong, N., Jinnett, K. N., Demko, Z., Zimmermann, B., Sigurjonsson, S., Gross, S. J., Hill, M. Validation of an enhanced version of a single-nucleotide polymorphism-based noninvasive prenatal test for detection of fetal aneuploidies Fetal Diagnosis and Therapy  2016 40:219-223  DOI:10.1159/000442931  PMID:27028530
    • Kirkizlar, E., Zimmermann, B., Constantin, T., Swenerton, R., Hoang, B., Wayham, N., Babiarz, J. E., Demko, Z., Pelham, R. J., Kareht, S., Simon, A. L., Jinnett, K. N., et al. Detection of clonal and subclonal copy-number variants in cell-free DNA from patients with breast cancer using a massively multiplexed PCR methodology Translational Oncology  2015 8:407-416  DOI:10.1016/j.tranon.2015.08.004  PMID:26500031  PMCID:PMC4631096
    • Simon, A. L., Su, B., Demko, Z., Rabinowitz, M., Harmon, E. R., Gross, S. J. Detection of complete molar pregnancy by single-nucleotide polymorphism-based non-invasive prenatal testing Ultrasound in Obstetrics & Gynecology  2015 46:506-507  DOI:10.1002/uog.14854  PMID:25810270
    • Wapner, R. J., Babiarz, J. E., Levy, B., Stosic, M., Zimmermann, B., Sigurjonsson, S., Wayham, N., Ryan, A., Banjevic, M., Lacroute, P., Hu, J., Hall, M. P., et al. Expanding the scope of noninvasive prenatal testing: detection of fetal microdeletion syndromes Obstetrical & Gynecological Survey  2015 70:481-482  DOI:10.1097/01.ogx.0000470656.81447.e7  PMID:25479548
    • McCoy, R. C., Demko, Z., Ryan, A., Banjevic, M., Hill, M., Sigurjonsson, S., Rabinowitz, M., Fraser, H. B., Petrov, D. A. Common variants spanning PLK4 are associated with mitotic-origin aneuploidy in human embryos Obstetrical & Gynecological Survey  2015 70:451-452
    • McCoy, R. C., Demko, Z., Ryan, A., Banjevic, M., Hill, M., Sigurjonsson, S., Rabinowitz, M., Fraser, H. B., Petrov, D. A. Common variants spanning PLK4 are associated with mitotic-origin aneuploidy in human embryos Science  2015 348:235-238  DOI:10.1126/science.aaa3337  PMID:25859044
    • Wapner, R. J., Babiarz, J. E., Levy, B., Stosic, M., Zimmermann, B., Sigurjonsson, S., Wayham, N., Ryan, A., Banjevic, M., Lacroute, P., Hu, J., Hall, M. P., et al. Expanding the scope of noninvasive prenatal testing: detection of fetal microdeletion syndromes American Journal of Obstetrics and Gynecology  2015 212:332.e1-9  DOI:10.1016/j.ajog.2014.11.041  PMID:25479548
    • McCoy, R. C., Demko, Z. P., Ryan, A., Banjevic, M., Hill, M., Sigurjonsson, S., Rabinowitz, M., Petrov, D. A. Evidence of selection against complex mitotic-origin aneuploidy during preimplantation development PLoS Genetics  2015 11  DOI:10.1371/journal.pgen.1005601  PMID:26491874  PMCID:PMC4619652
    • Curnow, K. J., Wilkins-Haug, L., Ryan, A., Kirkizlar, E., Stosic, M., Hall, M. P., Sigurjonsson, S., Demko, Z., Rabinowitz, M., Gross, S. J. Detection of triploid, molar, and vanishing twin pregnancies by a single-nucleotide polymorphism-based noninvasive prenatal test American Journal of Obstetrics and Gynecology  2015 212:79.e1-e9  DOI:10.1016/j.ajog.2014.10.012  PMID:25447960
    • Dar, P., Curnow, K. J., Gross, S. J., Hall, M. P., Stosic, M., Demko, Z., Zimmermann, B., Hill, M., Sigurjonsson, S., Ryan, A., Banjevic, M., Kolacki, P. L., et al. Clinical experience and follow-up with large scale single-nucleotide polymorphism-based noninvasive prenatal aneuploidy testing American Journal of Obstetrics and Gynecology  2014 211:527.e1-527.e17  DOI:10.1016/j.ajog.2014.08.006  PMID:25111587
    • Levy, B., Sigurjonsson, S., Pettersen, B., Maisenbacher, M. K., Hall, M. P., Demko, Z., Lathi, R. B., Tao, R., Aggarwal, V., Rabinowitz, M. Genomic imbalance in products of conception: single-nucleotide polymorphism chromosomal microarray analysis Obstetrics and Gynecology  2014 124:202-209  DOI:10.1097/aog.0000000000000325  PMID:25004334
    • Pergament, E., Cuckle, H., Zimmermann, B., Banjevic, M., Sigurjonsson, S., Ryan, A., Hall, M. P., Dodd, M., Lacroute, P., Stosic, M., Chopra, N., Hunkapiller, N., et al. Single-nucleotide polymorphism-based noninvasive prenatal screening in a high-risk and low-risk cohort Obstetrics and Gynecology  2014 124:210-218  DOI:10.1097/aog.0000000000000363  PMID:25004354  PMCID:PMC4144440
    • Hall, M. P., Hill, M., Zimmermann, B., Sigurjonsson, S., Westemeyer, M., Saucier, J., Demko, Z., Rabinowitz, M. Non-invasive prenatal detection of trisomy 13 using a single nucleotide polymorphism- and informatics-based approach PLoS One  2014 9  DOI:10.1371/journal.pone.0096677  PMID:24805989  PMCID:PMC4013011
    • Lathi, R. B., Gustin, S. L. F., Keller, J., Maisenbacher, M. K., Sigurjonsson, S., Tao, R., Demko, Z. Reliability of 46,XX results on miscarriage specimens: a review of 1,222 first-trimester miscarriage specimens Fertility and Sterility  2014 101:178-182  DOI:10.1016/j.fertnstert.2013.09.031  PMID:24182409
    • Samango-Sprouse, C., Banjevic, M., Ryan, A., Sigurjonsson, S., Zimmermann, B., Hill, M., Hall, M. P., Westemeyer, M., Saucier, J., Demko, Z., Rabinowitz, M. SNP-based non-invasive prenatal testing detects sex chromosome aneuploidies with high accuracy Prenatal Diagnosis  2013 33:643-649  DOI:10.1002/pd.4159  PMID:23712453  PMCID:PMC3764608
    • Ryan, A., Baner, J., Demko, Z., Hill, M., Sigurjonsson, S., Baird, M. L., Rabinowitz, M. Informatics-based, highly accurate, noninvasive prenatal paternity testing Genetics in Medicine  2013 15:473-477  DOI:10.1038/gim.2012.155  PMID:23258349  PMCID:PMC3910294
    • Zimmermann, B., Hill, M., Gemelos, G., Demko, Z., Banjevic, M., Baner, J., Ryan, A., Sigurjonsson, S., Chopra, N., Dodd, M., Levy, B., Rabinowitz, M. Noninvasive prenatal aneuploidy testing of chromosomes 13, 18, 21, X, and Y, using targeted sequencing of polymorphic loci Prenatal Diagnosis  2012 32:1233-1241  DOI:10.1002/pd.3993  PMID:23108718  PMCID:PMC3548605
    • Demko, Z., Zimmermann, B., Rabinowitz, M. Non-invasive prenatal testing for whole chromosome abnormalities Laboratoriumsmedizin-Journal of Laboratory Medicine  2012 36:263-267  DOI:10.1515/labmed-2012-0026
    • Lathi, R. B., Loring, M., Massie, J. A. M., Demko, Z. P., Johnson, D., Sigurjonsson, S., Gemelos, G., Rabinowitz, M. Informatics enhanced SNP microarray analysis of 30 miscarriage samples compared to routine cytogenetics PLoS One  2012 7  DOI:10.1371/journal.pone.0031282  PMID:22403611  PMCID:PMC3293871
    • Rabinowitz, M., Ryan, A., Gemelos, G., Hill, M., Baner, J., Cinnioglu, C., Banjevic, M., Potter, D., Petrov, D. A., Demko, Z. Origins and rates of aneuploidy in human blastomeres Fertility and Sterility  2012 97:395-401  DOI:10.1016/j.fertnstert.2011.11.034  PMID:22195772
    • degree-related publication Himo, F., Demko, Z. P., Noodleman, L. Density functional theory study of the intramolecular [2 + 3] cycloaddition of azide to nitriles Journal of Organic Chemistry  2003 68:9076-9080  DOI:10.1021/jo030137i  PMID:14604383
    • degree-related publication Himo, F., Demko, Z. P., Noodleman, L., Sharpless, K. B. Why is tetrazole formation by addition of azide to organic nitriles catalyzed by zinc(II) salts? Journal of the American Chemical Society  2003 125:9983-9987  DOI:10.1021/ja030204q  PMID:12914461
    • degree-related publication Himo, F., Demko, Z. P., Noodleman, L., Sharpless, K. B. Mechanisms of tetrazole formation by addition of azide to nitriles Journal of the American Chemical Society  2002 124:12210-12216  DOI:10.1021/ja0206644  PMID:12371861
    • degree-related publication Demko, Z. P., Sharpless, K. B. An expedient route to the tetrazole analogues of alpha-amino acids Organic Letters  2002 4:2525-2527  DOI:10.1021/ol020096x  PMID:12123367
    • degree-related publication Demko, Z. P., Sharpless, K. B. A click chemistry approach to tetrazoles by huisgen 1,3-dipolar cycloaddition: Synthesis of 5-acyltetrazoles from azides and acyl cyanides Angewandte Chemie-International Edition  2002 41:2113-2116  DOI:10.1002/1521-3773(20020617)41:12<2113::aid-anie2113>3.0.co;2-q  PMID:19746613
    • degree-related publication Demko, Z. P., Sharpless, K. B. A click chemistry approach to tetrazoles by huisgen 1,3-dipolar cycloaddition: Synthesis of 5-sulfonyl tetrazoles from azides and sulfonyl cyanides Angewandte Chemie-International Edition  2002 41:2110-2113  DOI:10.1002/1521-3773(20020617)41:12<2110::aid-anie2110>3.0.co;2-7  PMID:19746612
    • degree-related publication Demko, Z. P., Sharpless, K. B. An intramolecular 2+3 cycloaddition route to fused 5-heterosubstituted tetrazoles Organic Letters  2001 3:4091-4094  DOI:10.1021/ol010220x  PMID:11735592
    • degree-related publication Demko, Z. P., Sharpless, K. B. Preparation of 5-substituted 1h-tetrazoles from nitriles in water Journal of Organic Chemistry  2001 66:7945-7950  DOI:10.1021/jo010635w  PMID:11722189
    • degree-related publication Demko, Z. P., Bartsch, M., Sharpless, K. B. Primary amides. A general nitrogen source for catalytic asymmetric aminohydroxylation of olefins Organic Letters  2000 2:2221-2223  DOI:10.1021/ol000098m  PMID:10930248
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Background

education and training

  • Ph.D. in Chemistry, Scripps Research 1997 - 2002
  • B.S. in Chemical Engineering, Stanford University 1990 - 1994

advisee of

  • graduate advising relationship

    • Sharpless, K. Barry, Ph.D.  candidacy, 1998 - 2002
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Contact

full name

  • Zachary Paul Demko

geographic location

  • Scripps California 
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Identity

ORCID iD

  • ORCID iD http://orcid.org/0000-0001-8796-2381

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