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De Marco, Luigi
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De Marco, Luigi

Faculty Member Adjunct
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Positions

  • 2017 - Professor Adjunct, Molecular Medicine , Scripps Research
  • 2012 - Research Consultant, National Cancer Institute CRO Aviano
  • 2012 - Scientific Director, Sedicidodici
  • 2010 - Founding Partner, Isitec SRL Medical Devices
  • 2013 - 2017 Professor Adjunct, Molecular and Experimental Medicine (MEM) , Scripps Research
  • 2002 - 2012 Director, Department of Laboratory Diagnostics and Cellular Therapy, National Cancer Institute CRO Aviano
  • 1999 - 2012 Professor of Clinical Pathology, University of Udine
  • 1989 - 2012 Director of the Blood Bank and Clinical Pathology Laboratory, National Cancer Institute CRO Aviano
  • 1980 - 1989 Associate Director, Azienda Ospedaliera Pordenone
  • 1987 - 1988 Visiting Scientist, Scripps Research
  • 1978 - 1980 Visiting Scientist, Thomas Jefferson University
  • 1976 - 1978 Assistant Director of the Blood Bank and Coagualtion Laboratory, Azienda Ospedaliera Pordenone
  • 1974 - 1975 Medical Officer, Italian Army
  • 1973 - 1974 Assistant Medical Director, Azienda Ospedaliera Pordenone S. Maria degli Angeli
  • 1972 - 1973 Intern, University of Padova

Websites

  • Luigi De Marco, Ph.D.
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Publications

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  • academic article

    • Lombardi, E., Matte, A., Risitano, A. M., Ricklin, D., Lambris, J. D., De Zanet, D., Jokiranta, S. T., Martinelli, N., Scambi, C., Salvagno, G., Bisoffi, Z., Colato, C., et al. Factor H interferes with the adhesion of sickle red cells to vascular endothelium: a novel disease-modulating molecule Haematologica  2019 104:919-928  DOI:10.3324/haematol.2018.198622  PMID:30630982
    • Malara, A., Gruppi, C., Abbonante, V., Cattaneo, D., De Marco, L., Massa, M., Iurlo, A., Gianelli, U., Balduini, C. L., Tira, M. E., Muro, A. F., Chauhan, A. K., et al. EDA fibronectin-TLR4 axis sustains megakaryocyte expansion and inflammation in bone marrow fibrosis Journal of Experimental Medicine  2019 216:587-604  DOI:10.1084/jem.20181074  PMID:30733282  PMCID:PMC6400533
    • Malara, A., Gruppi, C., Celesti, G., Abbonante, V., Viarengo, G., Laghi, L., De Marco, L., Muro, A. F., Balduini, A. Alternatively spliced fibronectin extra domain A is required for hemangiogenic recovery upon bone marrow chemotherapy Haematologica  2018 103:E42-E45  DOI:10.3324/haematol.2017.173070  PMID:29146709  PMCID:PMC5792283
    • Mazzucato, M., Cozzi, M. R., Battiston, M., Jandrot-Perrus, M., Mongiat, M., Marchese, P., Kunicki, T. J., Ruggeri, Z. M., De Marco, L. Distinct spatio-temporal Ca(2+) signaling elicited by integrin alpha 2 beta 1 and glycoprotein VI under flow Blood  2009 114:2793-2801  DOI:10.1182/blood-2008-12-193490  PMID:19622836  PMCID:PMC2756134
    • Casonato, A., De Marco, L., Gallinaro, L., Sztukowska, M., Mazzuccato, M., Battiston, M., Pagnan, A., Ruggeri, Z. M. Altered von Willebrand factor subunit proteolysis and multimer processing associated with the Cys2362Phe mutation in the B2 domain Thrombosis and Haemostasis  2007 97:527-533  DOI:10.1160/th06-11-0647  PMID:17393013
    • Mazzucato, M., Cozzi, M. R., Pradella, P., Ruggeri, Z. M., De Marco, L. Distinct roles of ADP receptors in von Willebrand factor-mediated platelet signaling and activation under high flow Blood  2004 104:3221-3227  DOI:10.1182/blood-2004-03-1145  PMID:15284110
    • Kasirer-Friede, A., Cozzi, M. R., Mazzucato, M., De Marco, L., Ruggeri, Z. M., Shattil, S. J. Signaling through GP Ib-IX-V activates alpha IIb beta 3 independently of other receptors Blood  2004 103:3403-3411  DOI:10.1182/blood-2003-10-3664  PMID:14726383
    • Mazzucato, M., Pradella, P., Cozzi, M. R., De Marco, L., Ruggeri, Z. M. Sequential cytoplasmic calcium signals in a 2-stage platelet activation process induced by the glycoprotein Ib alpha mechanoreceptor Blood  2002 100:2793-2800  DOI:10.1182/blood-2002-02-0514  PMID:12351387
    • Mazzucato, M., De Marco, L., Masotti, A., Pradella, P., Bahou, W. F., Ruggeri, Z. M. Characterization of the initial alpha-thrombin interaction with glycoprotein Ib alpha in relation to platelet activation Journal of Biological Chemistry  1998 273:1880-1887  DOI:10.1074/jbc.273.4.1880  PMID:9442020
  • patent

    • Ruggeri, Z. M., Ware, J. L., De Marco, L., Mazzucato, M., inventors; Scripps Research, assignee. Bifunctional antithrombotic molecules and antithrombotic polypeptides World patent WO9311778A1 (1993).
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Background

education and training

  • M.D., University of Padova , Laboratory Medicine Residency Program 1983 - 1986
  • M.D., University of Padova , Nuclear Medicine Residency Program 1975 - 1978
  • M.D., University of Padova , Hematology Residency Program 1972 - 1975
  • M.D., University of Padova , Medical School 1966 - 1972
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Contact

full name

  • Luigi De Marco

geographic location

  • Scripps California 

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