recent publications
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academic article
- Flood, D. T., Kingston, C., Vantourout, J. C., Dawson, P. E., Baran, P. S. DNA encoded libraries: a visitor's guide Israel Journal of Chemistry 2020 DOI:10.1002/ijch.201900133
- Hackenberger, C. P. R., Dawson, P. E., Chen, Y. X., Hojo, H. Modern peptide and protein chemistry: Reaching new heights Journal of Organic Chemistry 2020 85:1328-1330 DOI:10.1021/acs.joc.0c00104 PMID:32028772
- Weidmann, J., Schnolzer, M., Dawson, P. E., Hoheisel, J. D. Copying Life: Synthesis of an enzymatically active mirror-image DNA-ligase made of D-amino acids Cell Chemical Biology 2019 26:645-651 DOI:10.1016/j.chembiol.2019.02.008 PMID:30880154
- Flood, D. T., Asai, S., Zhang, X., Wang, J., Yoon, L., Adams, Z. C., Dillingham, B. C., Sanchez, B. B., Vantourout, J. C., Flanagan, M. E., Piotrowsld, D. W., Richardson, P., et al. Expanding reactivity in DNA-encoded library synthesis via reversible binding of DNA to an inert quaternary ammonium support Journal of the American Chemical Society 2019 141:9998-10006 DOI:10.1021/jacs.9b03774 PMID:31136164
- Won, Y., Jeon, H., Pagar, A. D., Patil, M. D., Nadarajan, S. P., Flood, D. T., Dawson, P. E., Yun, H. In vivo biosynthesis of tyrosine analogs and their concurrent incorporation into a residue-specific manner for enzyme engineering Chemical Communications 2019 55:15133-15136 DOI:10.1039/c9cc08503c PMID:31789331
- Cistrone, P. A., Bird, M. J., Flood, D. T., Silvestri, A. P., Hintzen, J. C. J., Thompson, D. A., Dawson, P. E. Native chemical ligation of peptides and proteins Current Protocols in Chemical Biology 2019 11 DOI:10.1002/cpch.61 PMID:30645048 PMCID:PMC6384150
- Won, Y., Pagar, A. D., Patil, M. D., Dawson, P. E., Yun, H. Recent advances in enzyme engineering through incorporation of unnatural amino acids Biotechnology and Bioprocess Engineering 2019 24:592-604 DOI:10.1007/s12257-019-0163-x
- Palomo, V., Cistrone, P. A., Zhan, N., Palui, G., Mattoussi, H., Dawson, P. E. Efficient assembly of quantum dots with homogenous glycans derived from natural N-linked glycoproteins Bioconjugate Chemistry 2018 29:3144-3153 DOI:10.1021/acs.bioconjchem.8b00477 PMID:30063825
- Bird, M. J., Silvestri, A. P., Dawson, P. E. Expedient on-resin synthesis of peptidic benzimidazoles Bioorganic & Medicinal Chemistry Letters 2018 28:2679-2681 DOI:10.1016/j.bmcl.2018.04.062 PMID:29739642
- Flood, D. T., Hintzen, J. C. J., Bird, M. J., Cistrone, P. A., Chen, J. S., Dawson, P. E. Leveraging the Knorr pyrazole synthesis for the facile generation of thioester surrogates for use in native chemical ligation Angewandte Chemie-International Edition 2018 57:11634-11639 DOI:10.1002/anie.201805191 PMID:29908104 PMCID:PMC6126375
- Flood, D. T., Yan, N. L., Dawson, P. E. Post-translational backbone engineering through selenomethionine-mediated incorporation of Freidinger lactams Angewandte Chemie-International Edition 2018 57:8697-8701 DOI:10.1002/anie.201804885 PMID:29797386
- Cistrone, P. A., Silvestri, A. P., Hintzen, J. C. J., Dawson, P. E. Rigid peptide macrocycles from on-resin glaser stapling ChemBioChem 2018 19:1031-1035 DOI:10.1002/cbic.201800121 PMID:29516601
- Lee, T. C., Moran, C. R., Cistrone, P. A., Dawson, P. E., Deniz, A. A. Site-specific three-color labeling of α-synuclein via conjugation to uniquely reactive cysteines during assembly by native chemical ligation Cell Chemical Biology 2018 25:797-801 DOI:10.1016/j.chembiol.2018.03.009 PMID:29681525 PMCID:PMC6014907
- Silvestri, A. P., Cistrone, P. A., Dawson, P. E. Adapting the glaser reaction for bioconjugation: robust access to structurally simple, rigid linkers Angewandte Chemie-International Edition 2017 56:10438-10442 DOI:10.1002/anie.201705065 PMID:28685936
- Silvestri, A. P., Dawson, P. E. Base-catalyzed diastereoselective trimerization of trifluoroacetone Organic & Biomolecular Chemistry 2017 15:5131-5134 DOI:10.1039/c7ob01094j PMID:28594047
- Liew, S. K., Holownia, A., Diaz, D. B., Cistrone, P. A., Dawson, P. E., Yudin, A. K. Borylated oximes: versatile building blocks for organic synthesis Chemical Communications 2017 53:11237-11240 DOI:10.1039/c7cc06579e PMID:28959806
- Matthews, M. L., He, L., Horning, B. D., Olson, E. J., Correia, B. E., Yates III, J. R., Dawson, P. E., Cravatt, B. F. Chemoproteomic profiling and discovery of protein electrophiles in human cells Nature Chemistry 2017 9:234-243 DOI:10.1038/nchem.2645 PMID:28221344 PMCID:PMC5325178
- Algar, W. R., Khachatrian, A., Melinger, J. S., Huston, A. L., Stewart, M. H., Susumu, K., Blanco-Canosa, J. B., Oh, E., Dawson, P. E., Medintz, I. L. Concurrent modulation of quantum dot photoluminescence using a combination of charge transfer and Forster resonance energy transfer: competitive quenching and multiplexed biosensing modality Journal of the American Chemical Society 2017 139:363-372 DOI:10.1021/jacs.6b11042 PMID:28009161
- Adhikary, R., Tan, Y. X., Liu, J., Zimmermann, J., Holcomb, M., Yvellez, C., Dawson, P. E., Romesberg, F. E. Conformational heterogeneity and DNA recognition by the morphogen bicoid Biochemistry 2017 56:2787-2793 DOI:10.1021/acs.biochem.7b00255 PMID:28547993
- Breger, J. C., Muttenthaler, M., Delehanty, J. B., Thompson, D. A., Oh, E., Susumu, K., Deschamps, J. R., Anderson, G. P., Field, L. D., Walper, S. A., Dawson, P. E., Medintz, I. L. Nanoparticle cellular uptake by dendritic wedge peptides: achieving single peptide facilitated delivery Nanoscale 2017 9:10447-10464 DOI:10.1039/c7nr03362a PMID:28703833
- Susumu, K., Field, L. D., Oh, E., Hunt, M., Delehanty, J. B., Palomo, V., Dawson, P. E., Huston, A. L., Medintz, I. L. Purple-, blue-, and green-emitting multishell alloyed quantum dots: synthesis, characterization, and application for ratiometric extracellular pH sensing Chemistry of Materials 2017 29:7330-7344 DOI:10.1021/acs.chemmater.7b02174
- Nag, O. K., Stewart, M. H., Deschamps, J. R., Susumu, K., Oh, E., Tsytsarev, V., Tang, Q. G., Efros, A. L., Vaxenburg, R., Black, B. J., Chen, Y. C., O'Shaughnessy, T. J., et al. Quantum dot-peptide-fullerene bioconjugates for visualization of in vitro and in vivo cellular membrane potential ACS Nano 2017 11:5598-5613 DOI:10.1021/acsnano.7b00954 PMID:28514167
- Palomo, V., Diaz, S. A., Stewart, M. H., Susumu, K., Medintz, I. L., Dawson, P. E. 3,4-dihydroxyphenylalanine peptides as nonperturbative quantum dot sensors of aminopeptidase ACS Nano 2016 10:6090-6099 DOI:10.1021/acsnano.6b01682 PMID:27206058 PMCID:PMC4968404
- Thompson, D. A., Ng, R., Dawson, P. E. Arginine selective reagents for ligation to peptides and proteins Journal of Peptide Science 2016 22:311-319 DOI:10.1002/psc.2867 PMID:27005702
- Weidmann, J., Dimitrijevic, E., Hoheisel, J. D., Dawson, P. E. Boc-SPPS: Compatible linker for the synthesis of peptide o-aminoanilides Organic Letters 2016 18:164-167 DOI:10.1021/acs.orglett.5b03111 PMID:26702477
- Cistrone, P. A., Dawson, P. E. Click-based libraries of SFTI-1 peptides: new methods using reversed-phase silica ACS Combinatorial Science 2016 18:139-143 DOI:10.1021/acs.combsci.5b00195 PMID:26914614
- Olson, E. J., Lechtenberg, B. C., Zhao, C., Rubio de la Torre, E., Lamberto, I., Riedl, S. J., Dawson, P. E., Pasquale, E. B. Modifications of a nanomolar cyclic peptide antagonist for the EphA4 receptor to achieve high plasma stability ACS Medicinal Chemistry Letters 2016 7:841-846 DOI:10.1021/acsmedchemlett.6b00132 PMID:27660688 PMCID:PMC5018863
- Agten, S. M., Dawson, P. E., Hackeng, T. M. Oxime conjugation in protein chemistry: from carbonyl incorporation to nucleophilic catalysis Journal of Peptide Science 2016 22:271-279 DOI:10.1002/psc.2874 PMID:27006095
- Getz, T., Qin, J., Medintz, I. L., Delehanty, J. B., Susumu, K., Dawson, P. E., Dawson, G. Quantum dot-mediated delivery of siRNA to inhibit sphingomyelinase activities in brain-derived cells Journal of Neurochemistry 2016 139:872-885 DOI:10.1111/jnc.13841 PMID:27622309
- Reichart, T. M., Baksh, M. M., Rhee, J. K., Fiedler, J. D., Sligar, S. G., Finn, M. G., Zwick, M. B., Dawson, P. E. Trimerization of the HIV transmembrane domain in lipid bilayers modulates broadly neutralizing antibody binding Angewandte Chemie-International Edition 2016 55:2688-2692 DOI:10.1002/anie.201508421 PMID:26799917
- Zhan, N., Palui, G., Kapur, A., Palomo, V., Dawson, P. E., Mattoussi, H. Controlling the architecture, coordination, and reactivity of nanoparticle coating utilizing an amino acid central scaffold Journal of the American Chemical Society 2015 137:16084-16097 DOI:10.1021/jacs.5b10359 PMID:26621185
- Assem, N., Ferreira, D. J., Wolan, D. W., Dawson, P. E. Acetone-linked peptides: a convergent approach for peptide macrocyclization and labeling Angewandte Chemie-International Edition 2015 54:8665-8668 DOI:10.1002/anie.201502607 PMID:26096515 PMCID:PMC4824200
- Olea Jr., C., Weidmann, J., Dawson, P. E., Joyce, G. F. An L-RNA aptamer that binds and inhibits RNase Chemistry & Biology 2015 22:1437-1441 DOI:10.1016/j.chembiol.2015.09.017 PMID:26590636 PMCID:PMC4656138
- Zhang, H., Sturchler, E., Zhu, J., Nieto, A., Cistrone, P. A., Xie, J., He, L., Yea, K., Jones, T., Turn, R., Di Stefano, P. S., Griffin, P. R., et al. Autocrine selection of a GLP-1R G-protein biased agonist with potent antidiabetic effects Nature Communications 2015 6:8918 DOI:10.1038/ncomms9918 PMID:26621478 PMCID:PMC4686834
- Blanco-Canosa, J. B., Nardone, B., Albericio, F., Dawson, P. E. Chemical protein synthesis using a second-generation N-acylurea linker for the preparation of peptide-thioester precursors Journal of the American Chemical Society 2015 137:7197-7209 DOI:10.1021/jacs.5b03504 PMID:25978693
- Agarwal, R., Domowicz, M. S., Schwartz, N. B., Henry, J., Medintz, I., Delehanty, J. B., Stewart, M. H., Susumu, K., Huston, A. L., Deschamps, J. R., Dawson, P. E., Palomo, V., et al. Delivery and tracking of quantum dot peptide bioconjugates in an intact developing avian brain ACS Chemical Neuroscience 2015 6:494-504 DOI:10.1021/acschemneuro.5b00022 PMID:25688887 PMCID:PMC5056627
- Gemmill, K. B., Diaz, S. A., Blanco-Canosa, J. B., Deschamps, J. R., Pons, T., Liu, H. W., Deniz, A., Melinger, J., Oh, E., Susumu, K., Stewart, M. H., Hastman Jr., D. A., et al. Examining the polyproline nanoscopic ruler in the context of quantum dots Chemistry of Materials 2015 27:6222-6237 DOI:10.1021/acs.chemmater.5b03181
- Muttenthaler, M., Albericio, F., Dawson, P. E. Methods, setup and safe handling for anhydrous hydrogen fluoride cleavage in Boc solid-phase peptide synthesis Nature Protocols 2015 10:1067-1083 DOI:10.1038/nprot.2015.061 PMID:26086408
- Wang, W., Kapur, A., Ji, X., Safi, M., Palui, G., Palomo, V., Dawson, P. E., Mattoussi, H. Photoligation of an amphiphilic polymer with mixed coordination provides compact and reactive quantum dots Journal of the American Chemical Society 2015 137:5438-5451 DOI:10.1021/jacs.5b00671 PMID:25797052
- Kong, L., Kadam, R. U., Giang, E., Ruwona, T. B., Nieusma, T., Culhane, J. C., Stanfield, R. L., Dawson, P. E., Wilson, I. A., Law, M. Structure of hepatitis C virus envelope glycoprotein E1 antigenic site 314-324 in complex with antibody IGH526 Journal of Molecular Biology 2015 427:2617-2628 DOI:10.1016/j.jmb.2015.06.012 PMID:26135247 PMCID:PMC4523428
- Adhikary, R., Zimmermann, J., Dawson, P. E., Romesberg, F. E. Temperature Dependence of CN and SCN IR absorptions facilitates their interpretation and use as probes of proteins Analytical Chemistry 2015 87:11561-11567 DOI:10.1021/acs.analchem.5b03437 PMID:26523838
- Walters, R., Medintz, I. L., Delehanty, J. B., Stewart, M. H., Susumu, K., Huston, A. L., Dawson, P. E., Dawson, G. The role of negative charge in the delivery of quantum dots to neurons ASN Neuro 2015 7:pii DOI:10.1177/1759091415592389 PMID:26243591 PMCID:PMC4550297
- Aldeek, F., Hawkins, D., Palomo, V., Safi, M., Palui, G., Dawson, P. E., Alabugin, I., Mattoussi, H. UV and sunlight driven photoligation of quantum dots: understanding the photochemical transformation of the ligands Journal of the American Chemical Society 2015 137:2704-2714 DOI:10.1021/ja512802x PMID:25612193
- Thompson, D. A., Evans, E. G. B., Kasza, T., Millhauser, G. L., Dawson, P. E. Adapter reagents for protein site specific dye labeling Biopolymers 2014 102:273-279 DOI:10.1002/bip.22481 PMID:24599728 PMCID:PMC4851436
- Becker, C. F. W., Brik, A., Dawson, P., Hackenberger, C. P. R. Chemical protein synthesis Journal of Peptide Science 2014 20:63 DOI:10.1002/psc.2607 PMID:25975419
- Lamberto, I., Lechtenberg, B. C., Olson, E. J., Mace, P. D., Dawson, P. E., Riedl, S. J., Pasquale, E. B. Development and structural analysis of a nanomolar cyclic peptide antagonist for the EphA4 receptor ACS Chemical Biology 2014 9:2787-2795 DOI:10.1021/cb500677x PMID:25268696 PMCID:PMC4273976
- Wendeler, M., Grinberg, L., Wang, X., Dawson, P. E., Baca, M. Enhanced catalysis of oxime-based bioconjugations by substituted anilines Bioconjugate Chemistry 2014 25:93-101 DOI:10.1021/bc400380f PMID:24320725
- Adhikary, R., Zimmermann, J., Liu, J., Forrest, R. P., Janicki, T. D., Dawson, P. E., Corcelli, S. A., Romesberg, F. E. Evidence of an unusual N-H…N hydrogen bond in proteins Journal of the American Chemical Society 2014 136:13474-13477 DOI:10.1021/ja503107h PMID:25226114
- Adhikary, R., Zimmermann, J., Dawson, P. E., Romesberg, F. E. IR probes of protein microenvironments: utility and potential for perturbation ChemPhysChem 2014 15:849-853 DOI:10.1002/cphc.201400017 PMID:24519759
- Culhane, J. C., Dawson, P. E. Peptide pharmaceuticals: modifications to the peptide backbone that enhance stability and targeting Chimica Oggi-Chemistry Today 2014 32:17-20
- Scott, A. M., Algar, W. R., Stewart, M. H., Trammell, S. A., Blanco-Canosa, J. B., Dawson, P. E., Deschamps, J. R., Goswami, R., Oh, E., Huston, A. L., Medintz, I. L. Probing the quenching of quantum dot photoluminescence by peptide-labeled ruthenium(II) complexes Journal of Physical Chemistry C 2014 118:9239-9250 DOI:10.1021/jp501039w PMID:24817922 PMCID:PMC4010286
- Blanco-Canosa, J. B., Wu, M., Susumu, K., Petryayeva, E., Jennings, T. L., Dawson, P. E., Algar, W. R., Medintz, I. L. Recent progress in the bioconjugation of quantum dots Coordination Chemistry Reviews 2014 263:101-137 DOI:10.1016/j.ccr.2013.08.030
- Gemmill, K. B., Muttenthaler, M., Delehanty, J., Deschamps, J., Susumu, K., Stewart, M., Dawson, P., Huston, A., Medintz, I. Peptide-mediated cellular delivery of semiconductor quantum dots Proceedings of the SPIE 2013 8723:872311/1-872311/6 DOI:10.1117/12.2015446
- Algar, W. R., Blanco-Canosa, J. B., Manthe, R. L., Susumu, K., Stewart, M. H., Dawson, P. E., Medintz, I. L. Synthesizing and modifying peptides for chemoselective ligation and assembly into quantum dot-peptide bioconjugates Methods in Molecular Biology 2013 1025:47-73 DOI:10.1007/978-1-62703-462-3_5 PMID:23918329
- Stewart, M. H., Huston, A. L., Scott, A. M., Oh, E., Algar, W. R., Deschamps, J. R., Susumu, K., Jain, V., Prasuhn, D. E., Blanco-Canosa, J., Dawson, P. E., Medintz, I. L. Competition between Förster resonance energy transfer and electron transfer in stoichiometrically assembled semiconductor quantum dot-fullerene conjugates ACS Nano 2013 7:9489-9505 DOI:10.1021/nn403872x PMID:24128175
- Bradburne, C. E., Delehanty, J. B., Gemmill, K. B., Mei, B. C., Mattoussi, H., Susumu, K., Blanco-Canosa, J. B., Dawson, P. E., Medintz, I. L. Cytotoxicity of quantum dots used for in vitro cellular labeling: role of QD surface ligand, delivery modality, cell type, and direct comparison to organic fluorophores Bioconjugate Chemistry 2013 24:1570-1583 DOI:10.1021/bc4001917 PMID:23879393
- Gemmill, K. B., Muttenthaler, M., Delehanty, J. B., Stewart, M. H., Susumu, K., Dawson, P. E., Medintz, I. L. Evaluation of diverse peptidyl motifs for cellular delivery of semiconductor quantum dots Analytical and Bioanalytical Chemistry 2013 405:6145-6154 DOI:10.1007/s00216-013-6982-2 PMID:23732866
- Adhikary, R., Zimmermann, J., Liu, J., Dawson, P. E., Romesberg, F. E. Experimental characterization of electrostatic and conformational heterogeneity in an SH3 domain Journal of Physical Chemistry B 2013 117:13082-13089 DOI:10.1021/jp402772x PMID:23834285
- Doyle-Cooper, C., Hudson, K. E., Cooper, A. B., Ota, T., Skog, P., Dawson, P. E., Zwick, M. B., Schief, W. R., Burton, D. R., Nemazee, D. Immune tolerance negatively regulates B cells in knock-in mice expressing broadly neutralizing HIV antibody 4E10 Journal of Immunology 2013 191:3186-3191 DOI:10.4049/jimmunol.1301285 PMID:23940276 PMCID:PMC3773228
- Koehbach, J., O'Brien, M., Muttenthaler, M., Miazzo, M., Akcan, M., Elliott, A. G., Daly, N. L., Harvey, P. J., Arrowsmith, S., Gunasekera, S., Smith, T. J., Wray, S., et al. Oxytocic plant cyclotides as templates for peptide G protein-coupled receptor ligand design Proceedings of the National Academy of Sciences of the United States of America 2013 110:21183-21188 DOI:10.1073/pnas.1311183110 PMID:24248349 PMCID:PMC3876230
- Boeneman, K., Delehanty, J. B., Blanco-Canosa, J. B., Susumu, K., Stewart, M. H., Oh, E., Huston, A. L., Dawson, G., Ingale, S., Walters, R., Domowicz, M., Deschamps, J. R., et al. Selecting improved peptidyl motifs for cytosolic delivery of disparate protein and nanoparticle materials ACS Nano 2013 7:3778-3796 DOI:10.1021/nn400702r PMID:23710591 PMCID:PMC3880025
- Delehanty, J. B., Blanco-Canosa, J. B., Bradburne, C. E., Susumu, K., Stewart, M. H., Prasuhn, D. E., Dawson, P. E., Medintz, I. L. Site-specific cellular delivery of quantum dots with chemoselectively-assembled modular peptides Chemical Communications 2013 49:7878-7880 DOI:10.1039/c3cc42781a PMID:23759873
- Gemmill, K. B., Delehanty, J. B., Stewart, M. H., Susumu, K., Blanco-Canosa, J. B., Dawson, P. E., Huston, A., Medintz, I. Further progress in cytosolic cellular delivery of quantum dots Proceedings of the SPIE 2012 8232:82320B/1-82320B/7 DOI:10.1117/12.906801
- Yu, W., Dawson, P. E., Zimmermann, J., Romesberg, F. E. Carbon-deuterium bonds as probes of protein thermal unfolding Journal of Physical Chemistry B 2012 116:6397-6403 DOI:10.1021/jp303521t PMID:22625650
- Stewart, M. H., Huston, A. L., Scott, A. M., Efros, A. L., Melinger, J. S., Gemmill, K. B., Trammell, S. A., Blanco-Canosa, J. B., Dawson, P. E., Medintz, I. L. Complex Förster energy transfer interactions between semiconductor quantum dots and a redox-active osmium assembly ACS Nano 2012 6:5330-5347 DOI:10.1021/nn301177h PMID:22671940
- Wu, Z., Chen, K. V., Yildiz, I., Dirksen, A., Fischer, R., Dawson, P. E., Steinmetz, N. F. Development of viral nanoparticles for efficient intracellular delivery Nanoscale 2012 4:3567-3576 DOI:10.1039/c2nr30366c PMID:22508503 PMCID:PMC3563001
- Buckhout-White, S., Ancona, M., Oh, E., Deschamps, J. R., Stewart, M. H., Blanco-Canosa, J. B., Dawson, P. E., Goldman, E. R., Medintz, I. L. Multimodal characterization of a linear DNA-based nanostructure ACS Nano 2012 6:1026-1043 DOI:10.1021/nn204680r PMID:22257317
- Walters, R., Kraig, R. P., Medintz, I., Delehanty, J. B., Stewart, M. H., Susumu, K., Huston, A. L., Dawson, P. E., Dawson, G. Nanoparticle targeting to neurons in a rat hippocampal slice culture model ASN Neuro 2012 4:e00099 DOI:10.1042/an20120042 PMID:22973864 PMCID:PMC3479791
- Algar, W. R., Malonoski, A., Deschamps, J. R., Banco-Canosa, J. B., Susumu, K., Stewart, M. H., Johnson, B. J., Dawson, P. E., Medintz, I. L. Proteolytic activity at quantum dot-conjugates: kinetic analysis reveals enhanced enzyme activity and localized interfacial "hopping" Nano Letters 2012 12:3793-3802 DOI:10.1021/nl301727k PMID:22731798
- Algar, W. R., Wegner, D., Huston, A. L., Blanco-Canosa, J. B., Stewart, M. H., Armstrong, A., Dawson, P. E., Hildebrandt, N., Medintz, I. L. Quantum dots as simultaneous acceptors and donors in time-gated Förster resonance energy transfer relays: characterization and biosensing Journal of the American Chemical Society 2012 134:1876-1891 DOI:10.1021/ja210162f PMID:22220737
- Brik, A., Dawson, P. E., Kent, S. B. H. Chemical Protein Synthesis Israel Journal of Chemistry 2011 51:852-853 DOI:10.1002/ijch.201100087
- Zimmermann, J., Thielges, M. C., Yu, W., Dawson, P. E., Romesberg, F. E. Carbon-deuterium bonds as site-specific and nonperturbative probes for time-resolved studies of protein dynamics and folding Journal of Physical Chemistry Letters 2011 2:412-416 DOI:10.1021/jz200012h
- Oh, E., Delehanty, J. B., Sapsford, K. E., Susumu, K., Goswami, R., Blanco-Canosa, J. B., Dawson, P. E., Granek, J., Shoff, M., Zhang, Q., Goering, P. L., Huston, A., et al. Cellular uptake and fate of PEGylated gold nanoparticles is dependent on both cell-penetration peptides and particle size ACS Nano 2011 5:6434-6448 DOI:10.1021/nn201624c PMID:21774456
- Zimmermann, J., Thielges, M. C., Seo, Y. J., Dawson, P. E., Romesberg, F. E. Cyano groups as probes of protein microenvironments and dynamics Angewandte Chemie-International Edition 2011 50:8333-8337 DOI:10.1002/anie.201101016 PMID:21780257
- Sapsford, K. E., Granek, J., Deschamps, J. R., Boeneman, K., Blanco-Canosa, J. B., Dawson, P. E., Susumu, K., Stewart, M. H., Medintz, I. L. Monitoring botulinum neurotoxin a activity with peptide-functionalized quantum dot resonance energy transfer sensors ACS Nano 2011 5:2687-2699 DOI:10.1021/nn102997b PMID:21361387
- Susumu, K., Oh, E., Delehanty, J. B., Blanco-Canosa, J. B., Johnson, B. J., Jain, V., Hervey, W. J., Algar, W. R., Boeneman, K., Dawson, P. E., Medintz, I. L. Multifunctional compact zwitterionic ligands for preparing robust biocompatible semiconductor quantum dots and gold nanoparticles Journal of the American Chemical Society 2011 133:9480-9496 DOI:10.1021/ja201919s PMID:21612225
- Venter, P. A., Dirksen, A., Thomas, D., Manchester, M., Dawson, P. E., Schneemann, A. Multivalent display of proteins on viral nanoparticles using molecular recognition and chemical ligation strategies Biomacromolecules 2011 12:2293-2301 DOI:10.1021/bm200369e PMID:21545187 PMCID:PMC3114102
- Dawson, P. E. Native chemical ligation combined with desulfurization and deselenization: a general strategy for chemical protein synthesis Israel Journal of Chemistry 2011 51:862-867 DOI:10.1002/ijch.201100128
- Ingale, S., Dawson, P. E. On resin side-chain cyclization of complex peptides using CuAAC Organic Letters 2011 13:2822-2825 DOI:10.1021/ol200775h PMID:21553819
- Delehanty, J. B., Bradburne, C. E., Susumu, K., Boeneman, K., Mei, B. C., Farrell, D., Blanco-Canosa, J. B., Dawson, P. E., Mattoussi, H., Medintz, I. L. Spatiotemporal multicolor labeling of individual cells using peptide-functionalized quantum dots and mixed delivery techniques Journal of the American Chemical Society 2011 133:10482-10489 DOI:10.1021/ja200555z PMID:21627173
- Morgner, F., Stufler, S., Geissler, D., Medintz, I. L., Algar, W. R., Susumu, K., Stewart, M. H., Blanco-Canosa, J. B., Dawson, P. E., Hildebrandt, N. Terbium to quantum dot FRET bioconjugates for clinical diagnostics: influence of human plasma on optical and assembly properties Sensors 2011 11:9667-9684 DOI:10.3390/s111009667 PMID:22163719 PMCID:PMC3231297
- Algar, W. R., Prasuhn, D. E., Stewart, M. H., Jennings, T. L., Blanco-Canosa, J. B., Dawson, P. E., Medintz, I. L. The controlled display of biomolecules on nanoparticles: a challenge suited to bioorthogonal chemistry Bioconjugate Chemistry 2011 22:825-858 DOI:10.1021/bc200065z PMID:21585205
- Shekhter, T., Metanis, N., Dawson, P. E., Keinan, E. A residue outside the active site CXXC motif regulates the catalytic efficiency of Glutaredoxin 3 Molecular Biosystems 2010 6:241-248 DOI:10.1039/b912753d PMID:20024086 PMCID:PMC3820274
- Tiefenbrunn, T. K., Blanco-Canosa, J., Dawson, P. E. Alternative chemistries for the synthesis of thrombospondin-1 type 1 repeats Biopolymers 2010 94:405-413 DOI:10.1002/bip.21486 PMID:20593462 PMCID:PMC2906232
- Dirksen, A., Yegneswaran, S., Dawson, P. E. Bisaryl hydrazones as exchangeable biocompatible linkers Angewandte Chemie-International Edition 2010 49:2023-2027 DOI:10.1002/anie.200906756 PMID:20183838 PMCID:PMC4383167
- Tiefenbrunn, T. K., Dawson, P. E. Chemoselective ligation techniques: modern applications of time-honored chemistry Biopolymers 2010 94:95-106 DOI:10.1002/bip.21337 PMID:20091876
- Prasuhn, D. E., Blanco-Canosa, J. B., Vora, G. J., Delehanty, J. B., Susumu, K., Mei, B. C., Dawson, P. E., Medintz, I. L. Combining chemoselective ligation with polyhistidine-driven self-assembly for the modular display of biomolecules on quantum dots ACS Nano 2010 4:267-278 DOI:10.1021/nn901393v PMID:20099912 PMCID:PMC4756922
- Delehanty, J. B., Bradburne, C. E., Boeneman, K., Susumu, K., Farrell, D., Mei, B. C., Blanco-Canosa, J. B., Dawson, G., Dawson, P. E., Mattoussi, H., Medintz, I. L. Delivering quantum dot-peptide bioconjugates to the cellular cytosol: escaping from the endolysosomal system Integrative Biology 2010 2:265-277 DOI:10.1039/c0ib00002g PMID:20535418
- Sapsford, K. E., Blanco-Canosa, J. B., Dawson, P. E., Medintz, I. L. Detection of HIV-1 specific monoclonal antibodies using enhancement of dye-labeled antigenic peptides Bioconjugate Chemistry 2010 21:393-398 DOI:10.1021/bc9003712 PMID:20058910
- Brunel, F. M., Lewis, J. D., Destito, G., Steinmetz, N. F., Manchester, M., Stuhlmann, H., Dawson, P. E. Hydrazone ligation strategy to assemble multifunctional viral nanoparticles for cell imaging and tumor targeting Nano Letters 2010 10:1093-1097 DOI:10.1021/nl1002526 PMID:20163184 PMCID:PMC3988696
- Stewart, M. H., Susumu, K., Mei, B. C., Medintz, I. L., Delehanty, J. B., Blanco-Canosa, J. B., Dawson, P. E., Mattoussi, H. Multidentate poly(ethylene glycol) ligands provide colloidal stability to semiconductor and metallic nanocrystals in extreme conditions Journal of the American Chemical Society 2010 132:9804-9813 DOI:10.1021/ja102898d PMID:20578776
- Van de Vijver, P., Suylen, D., Dirksen, A., Dawson, P. E., Hackeng, T. M. N(epsilon)-(thiaprolyl)-lysine as a handle for site-specific protein conjugation Biopolymers 2010 94:465-474 DOI:10.1002/bip.21485 PMID:20593461
- Erlich, L. A., Kumar, K. S. A., Haj-Yahya, M., Dawson, P. E., Brik, A. N-methylcysteine-mediated total chemical synthesis of ubiquitin thioester Organic & Biomolecular Chemistry 2010 8:2392-2396 DOI:10.1039/c000332h PMID:20448897 PMCID:PMC3183995
- Dawson, G., Schroeder, C., Dawson, P. E. Palmitoyl:protein thioesterase (PPT1) inhibitors can act as pharmacological chaperones in infantile Batten disease Biochemical and Biophysical Research Communications 2010 395:66-69 DOI:10.1016/j.bbrc.2010.03.137 PMID:20346914 PMCID:PMC2881699
- Prasuhn, D. E., Deschamps, J. R., Susumu, K., Stewart, M. H., Boeneman, K., Blanco-Canosa, J. B., Dawson, P. E., Medintz, I. L. Polyvalent display and packing of peptides and proteins on semiconductor quantum dots: predicted versus experimental results Small 2010 6:555-564 DOI:10.1002/smll.200901845 PMID:20077423
- Oh, E., Susumu, K., Blanco-Canosa, J. B., Medintz, I. L., Dawson, P. E., Mattoussi, H. Preparation of stable maleimide-functionalized Au nanoparticles and their use in counting surface ligands Small 2010 6:1273-1278 DOI:10.1002/smll.201000279 PMID:20486227
- Boeneman, K., Deschamps, J. R., Buckhout-White, S., Prasuhn, D. E., Blanco-Canosa, J. B., Dawson, P. E., Stewart, M. H., Susumu, K., Goldman, E. R., Ancona, M., Medintz, I. L. Quantum dot DNA bioconjugates: attachment chemistry strongly influences the resulting composite architecture ACS Nano 2010 4:7253-7266 DOI:10.1021/nn1021346 PMID:21082822 PMCID:PMC4383186
- Prasuhn, D. E., Feltz, A., Blanco-Canosa, J. B., Susumu, K., Stewart, M. H., Mei, B. C., Yakovlev, A. V., Loukov, C., Mallet, J. M., Oheim, M., Dawson, P. E., Medintz, I. L. Quantum dot peptide biosensors for monitoring caspase 3 proteolysis and calcium ions ACS Nano 2010 4:5487-5497 DOI:10.1021/nn1016132 PMID:20822159
- Medintz, I. L., Stewart, M. H., Trammell, S. A., Susumu, K., Delehanty, J. B., Mei, B. C., Melinger, J. S., Blanco-Canosa, J. B., Dawson, P. E., Mattoussi, H. Quantum-dot/dopamine bioconjugates function as redox coupled assemblies for in vitro and intracellular pH sensing Nature Materials 2010 9:676-684 DOI:10.1038/nmat2811 PMID:20651808
- Blanco-Canosa, J. B., Medintz, I. L., Farrell, D., Mattoussi, H., Dawson, P. E. Rapid covalent ligation of fluorescent peptides to water solubilized quantum dots Journal of the American Chemical Society 2010 132:10027-10033 DOI:10.1021/ja910988d PMID:20597509 PMCID:PMC3182822
- Boeneman, K., Prasuhn, D. E., Blanco-Canosa, J. B., Dawson, P. E., Melinger, J. S., Ancona, M., Stewart, M. H., Susumu, K., Huston, A., Medintz, I. L. Self-assembled quantum dot-sensitized multivalent DNA photonic wires Journal of the American Chemical Society 2010 132:18177-18190 DOI:10.1021/ja106465x PMID:21141858
- Ingale, S., Gach, J. S., Zwick, M. B., Dawson, P. E. Synthesis and analysis of the membrane proximal external region epitopes of HIV-1 Journal of Peptide Science 2010 16:716-722 DOI:10.1002/psc.1325 PMID:21104968
- Metanis, N., Keinan, E., Dawson, P. E. Traceless ligation of cysteine peptides using selective deselenization Angewandte Chemie-International Edition 2010 49:7049-7053 DOI:10.1002/anie.201001900 PMID:20715234 PMCID:PMC4459706
- Pejchal, R., Gach, J. S., Brunel, F. M., Cardoso, R. M., Stanfield, R. L., Dawson, P. E., Burton, D. R., Zwick, M. B., Wilson, I. A. A conformational switch in human immunodeficiency virus gp41 revealed by the structures of overlapping epitopes recognized by neutralizing antibodies Journal of Virology 2009 83:8451-8462 DOI:10.1128/jvi.00685-09 PMID:19515770 PMCID:PMC2738203
- Vanacore, R., Ham, A. J. L., Voehler, M., Sanders, C. R., Conrads, T. P., Veenstra, T. D., Sharpless, K. B., Dawson, P. E., Hudson, B. G. A sulfilimine bond identified in collagen IV Science 2009 325:1230-1234 DOI:10.1126/science.1176811 PMID:19729652 PMCID:PMC2876822
- Tiefenbrunn, T. K., Dawson, P. E. Chemical synthesis and biotinylation of the thrombospondin domain TSR2 Protein Science 2009 18:970-979 DOI:10.1002/pro.107 PMID:19384999 PMCID:PMC2771299
- Cremeens, M. E., Zimmermann, J., Yu, W., Dawson, P. E., Romesberg, F. E. Direct observation of structural heterogeneity in a β-sheet Journal of the American Chemical Society 2009 131:5726-5727 DOI:10.1021/ja900505e PMID:19351132
- Kraut, D. A., Churchill, M. J., Dawson, P. E., Herschlag, D. Evaluating the potential for halogen bonding in the oxyanion hole of ketosteroid isomerase using unnatural amino acid mutagenesis ACS Chemical Biology 2009 4:269-273 DOI:10.1021/cb900016q PMID:19260691 PMCID:PMC2708088
- Zeng, Y., Ramya, T. N. C., Dirksen, A., Dawson, P. E., Paulson, J. C. High-efficiency labeling of sialylated glycoproteins on living cells Nature Methods 2009 6:207-209 DOI:10.1038/nmeth.1305 PMID:19234450 PMCID:PMC2830088
- Medintz, I. L., Farrell, D., Susumu, K., Trammell, S. A., Deschamps, J. R., Brunel, F. M., Dawson, P. E., Mattoussi, H. Multiplex charge-transfer interactions between quantum dots and peptide-bridged ruthenium complexes Analytical Chemistry 2009 81:4831-4839 DOI:10.1021/ac900412j PMID:19445483
- Thielges, M. C., Zimmermann, J., Dawson, P. E., Romesberg, F. E. The determinants of stability and folding in evolutionarily diverged cytochromes c Journal of Molecular Biology 2009 388:159-167 DOI:10.1016/j.jmb.2009.02.059 PMID:19268474 PMCID:PMC2990880
- Blanco-Canosa, J. B., Dawson, P. E. An efficient Fmoc-SPPS approach for the generation of thioester peptide precursors for use in native chemical ligation Angewandte Chemie-International Edition 2008 47:6851-6855 DOI:10.1002/anie.200705471 PMID:18651678 PMCID:PMC3182823
- Nelson, J. D., Kinkead, H., Brunel, F. M., Leaman, D., Jensen, R., Louis, J. M., Maruyama, T., Bewley, C. A., Bowdish, K., Clore, G. M., Dawson, P. E., Frederickson, S., et al. Antibody elicited against the gp41 N-heptad repeat (NHR) coiled-coil can neutralize HIV-1 with modest potency but non-neutralizing antibodies also bind to NHR mimetics Virology 2008 377:170-183 DOI:10.1016/j.virol.2008.04.005 PMID:18499210 PMCID:PMC2493441
- Weinkam, P., Zimmermann, J., Sagle, L. B., Matsuda, S., Dawson, P. E., Wolynes, P. G., Romesberg, F. E. Characterization of alkaline transitions in ferricytochrome c using carbon-deuterium infrared probes Biochemistry 2008 47:13470-13480 DOI:10.1021/bi801223n PMID:19035653 PMCID:PMC2853379
- Yamamoto, N., Tanabe, Y., Okamoto, R., Dawson, P. E., Kajihara, Y. Chemical synthesis of a glycoprotein having an intact human complex-type sialyloligosaccharide under the Boc and Fmoc synthetic strategies Journal of the American Chemical Society 2008 130:501-510 DOI:10.1021/ja072543f PMID:18085777
- Dirksen, A., Dawson, P. E. Expanding the scope of chemoselective peptide ligations in chemical biology Current Opinion in Chemical Biology 2008 12:760-766 DOI:10.1016/j.cbpa.2008.10.009 PMID:19058994
- Medintz, I. L., Pons, T., Trammell, S. A., Grimes, A. F., English, D. S., Blanco-Canosa, J. B., Dawson, P. E., Mattoussi, H. Interactions between redox complexes and semiconductor quantum dots coupled via a peptide bridge Journal of the American Chemical Society 2008 130:16745-16756 DOI:10.1021/ja805456x PMID:19049466 PMCID:PMC2779033
- Medintz, I. L., Pons, T., Delehanty, J. B., Susumu, K., Brunel, F. M., Dawson, P. E., Mattoussi, H. Intracellular delivery of quantum dot-protein cargos mediated by cell penetrating peptides Bioconjugate Chemistry 2008 19:1785-1795 DOI:10.1021/bc800089r PMID:18681468
- Burlina, F., Dixson, D. D., Doyle, R. P., Chassaing, G., Boddy, C. N., Dawson, P., Offer, J. Orthogonal ligation: a three piece assembly of a PNA-peptide-PNA conjugate Chemical Communications 2008 2785-2787 DOI:10.1039/b801242c PMID:18688310
- Dirksen, A., Dawson, P. E. Rapid oxime and hydrazone ligations with aromatic aldehydes for biomolecular labeling Bioconjugate Chemistry 2008 19:2543-2548 DOI:10.1021/bc800310p PMID:19053314 PMCID:PMC2761707
- Yegneswaran, S., Hackeng, T. M., Dawson, P. E., Griffin, J. H. The thrombin-sensitive region of protein S mediates phospholipid-dependent interaction with factor Xa Journal of Biological Chemistry 2008 283:33046-33052 DOI:10.1074/jbc.M806527200 PMID:18784085 PMCID:PMC2586267
- Nelson, J. D., Brunel, F. M., Jensen, R., Crooks, E. T., Cardoso, R. M. F., Wang, M., Hessell, A., Wilson, I. A., Binley, J. M., Dawson, P. E., Burton, D. R., Zwick, M. B. An affinity-enhanced neutralizing antibody against the membrane-proximal external region of human immunodeficiency virus type 1 gp41 recognizes an epitope between those of 2F5 and 4E10 Journal of Virology 2007 81:4033-4043 DOI:10.1128/jvi.02588-06 PMID:17287272 PMCID:PMC1866125
- Xu, Y., Hixon, M. S., Dawson, P. E., Janda, K. D. Development of a FRET assay for monitoring of HIV gp41 core disruption Journal of Organic Chemistry 2007 72:6700-6707 DOI:10.1021/jo070836l PMID:17685571
- Sapsford, K. E., Pons, T., Medintz, I. L., Higashiya, S., Brunel, F. M., Dawson, P. E., Mattoussi, H. Kinetics of metal-affinity driven self-assembly between proteins or peptides and CdSe-ZnS quantum dots Journal of Physical Chemistry C 2007 111:11528-11538 DOI:10.1021/jp073550t
- Yegneswaran, S., Tiefenbrunn, T. K., Fernandez, J. A., Dawson, P. E. Manipulation of thrombin exosite I, by ligand-directed covalent modification Journal of Thrombosis and Haemostasis 2007 5:2062-2069 DOI:10.1111/j.1538-7836.2007.02712.x PMID:17883702
- Cardoso, R. M. F., Brunel, F. M., Ferguson, S., Zwick, M., Burton, D. R., Dawson, P. E., Wilson, I. A. Structural basis of enhanced binding of extended and helically constrained peptide epitopes of the broadly neutralizing HIV-1 antibody 4E10 Journal of Molecular Biology 2007 365:1533-1544 DOI:10.1016/j.jmb.2006.10.088 PMID:17125793
- Blankenship, J. W., Dawson, P. E. Threading a peptide through a peptide: protein loops, rotaxanes, and knots Protein Science 2007 16:1249-1256 DOI:10.1110/ps.062673207 PMID:17567748 PMCID:PMC2206686
- Clapp, A. R., Pons, T., Medintz, I. L., Delehanty, J. B., Melinger, J. S., Tiefenbrunn, T., Dawson, P. E., Fisher, B. R., O'Rourke, B., Mattoussi, H. Two-photon excitation of quantum-dot-based fluorescence resonance energy transfer and its applications Advanced Materials 2007 19:1921-1926 DOI:10.1002/adma.200602036
- Sagle, L. B., Zimmermann, J., Dawson, P. E., Romesberg, F. E. Direct and high resolution characterization of cytochrome c equilibrium folding Journal of the American Chemical Society 2006 128:14232-14233 DOI:10.1021/ja065179d PMID:17076477
- Cremeens, M. E., Fujisaki, H., Zhang, Y., Zimmermann, J., Sagle, L. B., Matsuda, S., Dawson, P. E., Straub, J. E., Romesberg, F. E. Efforts toward developing direct probes of protein dynamics Journal of the American Chemical Society 2006 128:6028-6029 DOI:10.1021/ja061328g PMID:16669659
- Yamamoto, N., Takayanagi, A., Sakakibara, T., Dawson, P. E., Kajihara, Y. Highly efficient synthesis of sialylglycopeptides overcoming unexpected aspartimide formation during activation of Fmoc-Asn(undecadisialyloligosaccharide)-OH Tetrahedron Letters 2006 47:1341-1346 DOI:10.1016/j.tetlet.2005.12.064
- Dirksen, A., Dirksen, S., Hackeng, T. M., Dawson, P. E. Nucleophilic catalysis of hydrazone formation and transimination: implications for dynamic covalent chemistry Journal of the American Chemical Society 2006 128:15602-15603 DOI:10.1021/ja067189k PMID:17147365
- Dirksen, A., Hackeng, T. M., Dawson, P. E. Nucleophilic catalysis of oxime ligation Angewandte Chemie-International Edition 2006 45:7581-7584 DOI:10.1002/anie.200602877 PMID:17051631
- Medintz, I. L., Clapp, A. R., Brunel, F. M., Tiefenbrunn, T., Uyeda, H. T., Chang, E. L., Deschamps, J. R., Dawson, P. E., Mattoussi, H. Proteolytic activity monitored by fluorescence resonance energy transfer through quantum-dot-peptide conjugates Nature Materials 2006 5:581-589 DOI:10.1038/nmat1676 PMID:16799548
- Sagle, L. B., Zimmermann, J., Matsuda, S., Dawson, P. E., Romesberg, F. E. Redox-coupled dynamics and folding in cytochrome c Journal of the American Chemical Society 2006 128:7909-7915 DOI:10.1021/ja060851s PMID:16771505
- Delehanty, J. B., Medintz, I. L., Pons, T., Brunel, F. M., Dawson, P. E., Mattoussi, H. Self-assembled quantum dot-peptide bioconjugates for selective intracellular delivery Bioconjugate Chemistry 2006 17:920-927 DOI:10.1021/bc060044i PMID:16848398 PMCID:PMC2519024
- Brunel, F. M., Zwick, M. B., Cardoso, R. M. F., Nelson, J. D., Wilson, I. A., Burton, D. R., Dawson, P. E. Structure-function analysis of the epitope for 4E10, a broadly neutralizing human immunodeficiency virus type 1 antibody Journal of Virology 2006 80:1680-1687 DOI:10.1128/jvi.80.4.1680-1687.2006 PMID:16439525 PMCID:PMC1367132
- Metanis, N., Keinan, E., Dawson, P. E. Synthetic seleno-glutaredoxin 3 analogues are highly reducing oxidoreductases with enhanced catalytic efficiency Journal of the American Chemical Society 2006 128:16684-16691 DOI:10.1021/ja0661414 PMID:17177418 PMCID:PMC2532977
- Metanis, N., Keinan, E., Dawson, P. E. A designed synthetic analogue of 4-OT is specific for a non-natural substrate Journal of the American Chemical Society 2005 127:5862-5868 DOI:10.1021/ja050110b PMID:15839684
- Neuman, B. W., Stein, D. A., Kroeker, A. D., Churchill, M. J., Kim, A. M., Kuhn, P., Dawson, P., Moulton, H. M., Bestwick, R. K., Iversen, P. L., Buchmeier, M. J. Inhibition, escape, and attenuated growth of severe acute respiratory syndrome coronavirus treated with antisense morpholino oligomers Journal of Virology 2005 79:9665-9676 DOI:10.1128/jvi.79.15.9665-9676.2005 PMID:16014928 PMCID:PMC1181598
- Beltran, A. C., Dawson, P. E., Gottesfeld, J. M. Role of DNA sequence in the binding specificity of synthetic basic-helix-loop-helix domains ChemBioChem 2005 6:104-113 DOI:10.1002/cbic.200400184 PMID:15593070
- McNulty, J. C., Jackson, P. J., Thompson, D. A., Chai, B. X., Gantz, I., Barsh, G. S., Dawson, P. E., Millhauser, G. L. Structures of the agouti signaling protein Journal of Molecular Biology 2005 346:1059-1070 DOI:10.1016/j.jmb.2004.12.030 PMID:15701517
- Brunel, F. M., Dawson, P. E. Synthesis of constrained helical peptides by thioether ligation: application to analogs of gp41 Chemical Communications 2005 2552-2554 DOI:10.1039/b419015g PMID:15900323
- Sagle, L. B., Zimmermann, J., Dawson, P. E., Romesberg, F. E. A high-resolution probe of protein folding Journal of the American Chemical Society 2004 126:3384-3385 DOI:10.1021/ja049890z PMID:15025440
- Marinzi, C., Offer, J., Longhi, R., Dawson, P. E. An o-nitrobenzyl scaffold for peptide ligation: synthesis and applications Bioorganic & Medicinal Chemistry 2004 12:2749-2757 DOI:10.1016/j.bmc.2004.02.039 PMID:15110856
- Deechongkit, S., Nguyen, H., Powers, E. T., Dawson, P. E., Gruebele, M., Kelly, J. W. Context-dependent contributions of backbone hydrogen bonding to β-sheet folding energetics Nature 2004 430:101-105 DOI:10.1038/nature02611 PMID:15229605
- Kamikubo, Y., De Guzman, R., Kroon, G., Curriden, S., Neels, J. G., Churchill, M. J., Dawson, P., Oldziej, S., Jagielska, A., Scheraga, H. A., Loskutoff, D. J., Dyson, H. J. Disulfide bonding arrangements in active forms of the somatomedin B domain of human vitronectin Biochemistry 2004 43:6519-6534 DOI:10.1021/bi049647c PMID:15157085
- Dawson, P. E., Leumann, C. J. Editorial overview: Challenge complex biological function with smart chemistry Current Opinion in Chemical Biology 2004 8:567-569 DOI:10.1016/j.cbpa.2004.10.006
- Metanis, N., Brik, A., Dawson, P. E., Keinan, E. Electrostatic interactions dominate the catalytic contribution of Arg39 in 4-oxalocrotonate tautomerase Journal of the American Chemical Society 2004 126:12726-12727 DOI:10.1021/ja0463841 PMID:15469238
- Deechongkit, S., Dawson, P. E., Kelly, J. W. Toward assessing the position-dependent contributions of backbone hydrogen bonding to β-sheet folding thermodynamics employing amide-to-ester perturbations Journal of the American Chemical Society 2004 126:16762-16771 DOI:10.1021/ja045934s PMID:15612714
- Zwick, M. B., Parren, P. W., Saphire, E. O., Church, S., Wang, M., Scott, J. K., Dawson, P. E., Wilson, I. A., Burton, D. R. Molecular features of the broadly neutralizing immunoglobulin G1 b12 required for recognition of human immunodeficiency virus type 1 gp120 Journal of Virology 2003 77:5863-5876 DOI:10.1128/jvi.77.10.5863-5876.2003 PMID:12719580 PMCID:PMC154005
- Bayro, M. J., Mukhopadhyay, J., Swapna, G. V. T., Huang, J. Y., Ma, L. C., Sineva, E., Dawson, P. E., Montelione, G. T., Ebright, R. H. Structure of antibacterial peptide microcin J25: a 21-residue lariat protoknot Journal of the American Chemical Society 2003 125:12382-12383 DOI:10.1021/ja036677e PMID:14531661
- Blankenship, J. W., Dawson, P. E. Thermodynamics of a designed protein catenane Journal of Molecular Biology 2003 327:537-548 DOI:10.1016/s0022-2836(03)00115-3 PMID:12628256
- Dawson, G., Dawson, S. A., Marinzi, C., Dawson, P. E. Anti-tumor promoting effects of palmitoyl: protein thioesterase inhibitors against a human neurotumor cell line Cancer Letters 2002 187:163-168 DOI:10.1016/s0304-3835(02)00403-2 PMID:12359364
- Offer, J., Boddy, C. N. C., Dawson, P. E. Extending synthetic access to proteins with a removable acyl transfer auxiliary Journal of the American Chemical Society 2002 124:4642-4646 DOI:10.1021/ja016731w PMID:11971712
- Yegneswaran, S., Fernandez, J. A., Griffin, J. H., Dawson, P. E. Factor Va increases the affinity of factor Xa for prothrombin: a binding study using a novel photoactivable thiol-specific fluorescent probe Chemistry & Biology 2002 9:485-494 DOI:10.1016/s1074-5521(02)00132-1 PMID:11983337
- Brik, A., D'Souza, L. J., Keinan, E., Grynszpan, F., Dawson, P. E. Mutants of 4-oxalocrotonate tautomerase catalyze the decarboxylation of oxaloacetate through an imine mechanism ChemBioChem 2002 3:845-851 DOI:10.1002/1439-7633(20020902)3:9<845::aid-cbic845>3.0.co;2-2 PMID:12210985
- Marx, P. F., Dawson, P. E., Bouma, B. N., Meijers, J. C. M. Plasmin-mediated activation and inactivation of thrombin-activatable fibrinolysis inhibitor Biochemistry 2002 41:6688-6696 DOI:10.1021/bi015982e PMID:12022872
- Blankenship, J. W., Balambika, R., Dawson, P. E. Probing backbone hydrogen bonds in the hydrophobic core of GCN4 Biochemistry 2002 41:15676-15684 DOI:10.1021/bi026862p PMID:12501196
- Brik, A., Dawson, P. E., Keinan, E. The product of the natural reaction catalyzed by 4-oxalocrotonate tautomerase becomes an affinity label of its mutant Bioorganic & Medicinal Chemistry 2002 10:3891-3897 DOI:10.1016/s0968-0896(02)00385-1 PMID:12413840
- Marinzi, C., Bark, S. J., Offer, J., Dawson, P. E. A new scaffold for amide ligation Bioorganic & Medicinal Chemistry 2001 9:2323-2328 DOI:10.1016/s0968-0896(01)00136-5 PMID:11553471
- Yan, L. Z., Dawson, P. E. Design and synthesis of a protein catenane Angewandte Chemie-International Edition 2001 40:3625-3627 DOI:10.1002/1521-3773(20011001)40:19<3625::aid-anie3625>3.0.co;2-q PMID:11592201
- Yan, L. Z., Dawson, P. E. Synthesis of peptides and proteins without cysteine residues by native chemical ligation combined with desulfurization Journal of the American Chemical Society 2001 123:526-533 DOI:10.1021/ja003265m PMID:11456564
- Cho, S. G., Dawson, P. E., Dawson, G. Antisense palmitoyl protein thioesterase 1 (PPT1) treatment inhibits PPT1 activity and increases cell death in LA-N-5 neuroblastoma cells Journal of Neuroscience Research 2000 62:234-240 DOI:10.1002/1097-4547(20001015)62:2<234::aid-jnr8>3.0.co;2-8 PMID:11020216
- Hackeng, T. M., Fernandez, J. A., Dawson, P. E., Kent, S. B. H., Griffin, J. H. Chemical synthesis and spontaneous folding of a multidomain protein: anticoagulant microprotein S Proceedings of the National Academy of Sciences of the United States of America 2000 97:14074-14078 DOI:10.1073/pnas.260239797 PMID:11106381 PMCID:PMC18873
- Beligere, G. S., Dawson, P. E. Design, synthesis, and characterization of 4-ester CI2, a model for backbone hydrogen bonding in protein α-helices Journal of the American Chemical Society 2000 122:12079-12082 DOI:10.1021/ja001648e
- Beck, Z. Q., Hervio, L., Dawson, P. E., Elder, J. H., Madison, E. L. Identification of efficiently cleaved substrates for HIV-1 protease using a phage display library and use in inhibitor development Virology 2000 274:391-401 DOI:10.1006/viro.2000.0420 PMID:10964781
- Cho, S. G., Dawson, P. E., Dawson, G. In vitro depalmitoylation of neurospecific peptides: implication for infantile neuronal ceroid lipofuscinosis Journal of Neuroscience Research 2000 59:32-38 DOI:10.1002/(sici)1097-4547(20000101)59:1<32::aid-jnr5>3.0.co;2-a PMID:10658183
- Marx, P. F., Hackeng, T. M., Dawson, P. E., Griffin, J. H., Meijers, J. C. M., Bouma, B. N. Inactivation of active thrombin-activable fibrinolysis inhibitor takes place by a process that involves conformational instability rather than proteolytic cleavage Journal of Biological Chemistry 2000 275:12410-12415 DOI:10.1074/jbc.275.17.12410 PMID:10777524
- Offer, J., Dawson, P. E. N-alpha-2-mercaptobenzylamine-assisted chemical ligation Organic Letters 2000 2:23-26 DOI:10.1021/ol991184t PMID:10814236
- Pelletier, A. J., van der Laan, L. J. W., Hildbrand, P., Siani, M. A., Thompson, D. A., Dawson, P. E., Torbett, B. E., Salomon, D. R. Presentation of chemokine SDF-1α by fibronectin mediates directed migration of T cells Blood 2000 96:2682-2690 PMID:11023498
- Brik, A., Keinan, E., Dawson, P. E. Protein synthesis by solid-phase chemical ligation using a safety catch linker Journal of Organic Chemistry 2000 65:3829-3835 DOI:10.1021/jo000346s PMID:10864771
- Deniz, A. A., Laurence, T. A., Beligere, G. S., Dahan, M., Martin, A. B., Chemla, D. S., Dawson, P. E., Schultz, P. G., Weiss, S. Single-molecule protein folding: diffusion fluorescence resonance energy transfer studies of the denaturation of chymotrypsin inhibitor 2 Proceedings of the National Academy of Sciences of the United States of America 2000 97:5179-5184 DOI:10.1073/pnas.090104997 PMID:10792044 PMCID:PMC25802
- King, C. C., Zenke, F. T., Dawson, P. E., Dutil, E. M., Newton, A. C., Hemmings, B. A., Bokoch, G. M. Sphingosine is a novel activator of 3-phosphoinositide-dependent kinase 1 Journal of Biological Chemistry 2000 275:18108-18113 DOI:10.1074/jbc.M909663199 PMID:10748151
- Dawson, P. E., Kent, S. B. H. Synthesis of native proteins by chemical ligation Annual Review of Biochemistry 2000 69:923-960 DOI:10.1146/annurev.biochem.69.1.923 PMID:10966479
- Beligere, G. S., Dawson, P. E. Conformationally assisted protein ligation using C-terminal thioester peptides Journal of the American Chemical Society 1999 121:6332-6333 DOI:10.1021/ja9907919
- Hackeng, T. M., Griffin, J. H., Dawson, P. E. Protein synthesis by native chemical ligation: expanded scope by using straightforward methodology Proceedings of the National Academy of Sciences of the United States of America 1999 96:10068-10073 DOI:10.1073/pnas.96.18.10068 PMID:10468563 PMCID:PMC17843
- Coombs, G. S., Rao, M. S., Olson, A. J., Dawson, P. E., Madison, E. L. Revisiting catalysis by chymotrypsin family serine proteases using peptide substrates and inhibitors with unnatural main chains Journal of Biological Chemistry 1999 274:24074-24079 DOI:10.1074/jbc.274.34.24074 PMID:10446178
- Beligere, G. S., Dawson, P. E. Synthesis of a three zinc finger protein, Zif268, by native chemical ligation Biopolymers 1999 51:363-369 DOI:10.1002/(sici)1097-0282(1999)51:5<363::aid-bip6>3.3.co;2-f PMID:10685047
- Hackeng, T. M., Dawson, P. E., Kent, S. B. H., Griffin, J. H. Chemical synthesis of human protein S thrombin-sensitive module and first epidermal growth factor module Biopolymers 1998 46:53-63 DOI:10.1002/(sici)1097-0282(199808)46:2<53::aid-bip1>3.3.co;2-6 PMID:9664841
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Dawson, P. E., Fitzgerald, M. C., Muir, T. W., Kent, S. B. H.
Methods for the chemical synthesis and readout of self-encoded arrays of polypeptide analogues
Journal of the American Chemical Society
1997
119:7917-7927
DOI:10.1021/ja963122t
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Dawson, P. E., Churchill, M. J., Ghadiri, M. R., Kent, S. B. H.
Modulation of reactivity in native chemical ligation through the use of thiol additives
Journal of the American Chemical Society
1997
119:4325-4329
DOI:10.1021/ja962656r
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Muir, T. W., Dawson, P. E., Fitzgerald, M. C., Kent, S. B. H.
Protein signature analysis: a practical new approach for studying structure-activity relationships in peptides and proteins
Methods in Enzymology
1997
289:545-564
DOI:10.1016/S0076-6879(97)89063-5
PMID:9353737
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Muir, T. W., Dawson, P. E., Kent, S. B. H.
Protein synthesis by chemical ligation of unprotected peptides in aqueous solution
Methods in Enzymology
1997
289:266-298
DOI:10.1016/S0076-6879(97)89052-0
PMID:9353726
- Dawson, P. E. Synthesis of chemokines by native chemical ligation Methods in Enzymology 1997 287:34-45 DOI:10.1016/S0076-6879(97)87005-X PMID:9330313
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Hackeng, T. M., Mounier, C. M., Bon, C., Dawson, P. E., Griffin, J. H., Kent, S. B. H.
Total chemical synthesis of enzymatically active human type II secretory phospholipase A2
Proceedings of the National Academy of Sciences of the United States of America
1997
94:7845-7850
DOI:10.1073/pnas.94.15.7845
PMID:9223275
PMCID:PMC21517
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Muir, T. W., Dawson, P. E., Fitzgerald, M. C., Kent, S. B. H.
Probing the chemical basis of binding activity in an SH3 domain by protein signature analysis
Chemistry & Biology
1996
3:817-825
DOI:10.1016/s1074-5521(96)90067-8
PMID:8939700
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Bruick, R. K., Dawson, P. E., Kent, S. B., Usman, N., Joyce, G. F.
Template-directed ligation of peptides to oligonucleotides
Chemistry & Biology
1996
3:49-56
DOI:10.1016/s1074-5521(96)90084-8
PMID:8807828
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Dawson, P. E., Muir, T. W., Clark-Lewis, I., Kent, S. B. H.
Synthesis of proteins by native chemical ligation
Science
1994
266:776-779
DOI:10.1126/science.7973629
PMID:7973629
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Dawson, P. E., Kent, S. B. H.
Convenient total synthesis of a 4-helix TASP molecule by chemoselective ligation
Journal of the American Chemical Society
1993
115:7263-7266
DOI:10.1021/ja00069a027
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chapter
- Chemical synthesis of proteins and large bioconjugates Chemical biology : from small molecules to systems biology and drug design. 567-592. 2008 DOI:10.1002/9783527619375.ch10b
- Dawson, P. E., Offer, J. Protein synthesis on solid support Science of Synthesis. 713-714. 2003
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thesis