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Dawson, Philip
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Dawson, Philip

Dean of Graduate & Postdoctoral Studies
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Positions

  • 2017 - Dean, Skaggs Graduate School of Chemical and Biological Sciences , Scripps Research
  • 2017 - Professor (Joint Appointment), Molecular Medicine , Scripps Research
  • 2016 - Professor, Chemistry , Scripps Research
  • 2016 - 2017 Professor, Cell and Molecular Biology (CMB) , Scripps Research
  • 2012 - 2017 Associate Dean of Graduate Studies, Skaggs Graduate School of Chemical and Biological Sciences , Scripps Research
  • 2013 - 2016 Associate Professor (Joint Appointment), Cell and Molecular Biology (CMB) , Scripps Research
  • 2005 - 2016 Associate Professor, Chemistry , Scripps Research
  • 2005 - 2012 Associate Professor (Joint Appointment), Cell Biology , Scripps Research
  • 1997 - 2005 Assistant Professor (Joint Appointment), Cell Biology , Scripps Research
  • 1997 - 2005 Assistant Professor, Chemistry , Scripps Research
  • 1996 - 1997 Postdoctoral Scholar with Dr. Harry B. Gray, Department of Chemistry, California Institute of Technology
Dr. Philip Dawson develops novel chemical ligation methodologies for the synthesis of natural and chemically engineered proteins to develop novel peptide based vaccines for HIV-1, study the molecular basis of protein folding and enzymatic catalysis, conjugate biological macromolecules to in complex systems such as cells, viruses and Quantum Dots and to develop synthetic protein pharmaceuticals.

Research Areas research areas

  • Biocatalysis and Protein Design

Contact

  • dawson@scripps.edu

Websites

  • Philip Dawson, Ph.D.
  • Laboratory Website
  • Doctoral Dissertation
  • Publications
  • Research
  • Teaching
  • Background
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Publications

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    • Flood, D. T., Zhang, X. J., Fu, X., Zhao, Z. X., Asai, S., Sanchez, B. B., Sturgell, E. J., Vantourout, J. C., Richardson, P., Flanagan, M. E., Piotrowski, D. W., K?lmel, D. K., et al. RASS-Enabled S/P-C and S-N Bond Formation for DEL Synthesis Angewandte Chemie-International Edition  2020 59:7377-7383  DOI:10.1002/anie.201915493  PMID:32050046
    • Flood, D. T., Kingston, C., Vantourout, J. C., Dawson, P. E., Baran, P. S. DNA encoded libraries: a visitor's guide Israel Journal of Chemistry  2020  DOI:10.1002/ijch.201900133
    • Hackenberger, C. P. R., Dawson, P. E., Chen, Y. X., Hojo, H. Modern peptide and protein chemistry: Reaching new heights Journal of Organic Chemistry  2020 85:1328-1330  DOI:10.1021/acs.joc.0c00104  PMID:32028772
    • Vantourout, J. C., Adusumalli, S. R., Knouse, K. W., Flood, D. T., Ramirez, A., Padial, N. M., Istrate, A., Maziarz, K., DeGruyter, J. N., Merchant, R. R., Qiao, J. X., Schmidt, M. A., et al. Serine-Selective Bioconjugation Journal of the American Chemical Society  2020 142:17236-17242  DOI:10.1021/jacs.0c05595  PMID:32965106
    • Won, Y., Jeon, H., Pagar, A. D., Patil, M. D., Nadarajan, S. P., Flood, D. T., Dawson, P. E., Yun, H. In vivo biosynthesis of tyrosine analogs and their concurrent incorporation into a residue-specific manner for enzyme engineering Chemical Communications  2019 55:15133-15136  DOI:10.1039/c9cc08503c  PMID:31789331
    • Won, Y., Pagar, A. D., Patil, M. D., Dawson, P. E., Yun, H. Recent advances in enzyme engineering through incorporation of unnatural amino acids Biotechnology and Bioprocess Engineering  2019 24:592-604  DOI:10.1007/s12257-019-0163-x
    • Flood, D. T., Asai, S., Zhang, X., Wang, J., Yoon, L., Adams, Z. C., Dillingham, B. C., Sanchez, B. B., Vantourout, J. C., Flanagan, M. E., Piotrowsld, D. W., Richardson, P., et al. Expanding reactivity in DNA-encoded library synthesis via reversible binding of DNA to an inert quaternary ammonium support Journal of the American Chemical Society  2019 141:9998-10006  DOI:10.1021/jacs.9b03774  PMID:31136164
    • Weidmann, J., Schnolzer, M., Dawson, P. E., Hoheisel, J. D. Copying Life: Synthesis of an enzymatically active mirror-image DNA-ligase made of D-amino acids Cell Chemical Biology  2019 26:645-651  DOI:10.1016/j.chembiol.2019.02.008  PMID:30880154
    • Cistrone, P. A., Bird, M. J., Flood, D. T., Silvestri, A. P., Hintzen, J. C. J., Thompson, D. A., Dawson, P. E. Native chemical ligation of peptides and proteins Current Protocols in Chemical Biology  2019 11  DOI:10.1002/cpch.61  PMID:30645048  PMCID:PMC6384150
    • Flood, D. T., Hintzen, J. C. J., Bird, M. J., Cistrone, P. A., Chen, J. S., Dawson, P. E. Leveraging the Knorr pyrazole synthesis for the facile generation of thioester surrogates for use in native chemical ligation Angewandte Chemie-International Edition  2018 57:11634-11639  DOI:10.1002/anie.201805191  PMID:29908104  PMCID:PMC6126375
    • Palomo, V., Cistrone, P. A., Zhan, N., Palui, G., Mattoussi, H., Dawson, P. E. Efficient assembly of quantum dots with homogenous glycans derived from natural N-linked glycoproteins Bioconjugate Chemistry  2018 29:3144-3153  DOI:10.1021/acs.bioconjchem.8b00477  PMID:30063825
    • Bird, M. J., Silvestri, A. P., Dawson, P. E. Expedient on-resin synthesis of peptidic benzimidazoles Bioorganic & Medicinal Chemistry Letters  2018 28:2679-2681  DOI:10.1016/j.bmcl.2018.04.062  PMID:29739642
    • Flood, D. T., Yan, N. L., Dawson, P. E. Post-translational backbone engineering through selenomethionine-mediated incorporation of Freidinger lactams Angewandte Chemie-International Edition  2018 57:8697-8701  DOI:10.1002/anie.201804885  PMID:29797386
    • Lee, T. C., Moran, C. R., Cistrone, P. A., Dawson, P. E., Deniz, A. A. Site-specific three-color labeling of α-synuclein via conjugation to uniquely reactive cysteines during assembly by native chemical ligation Cell Chemical Biology  2018 25:797-801  DOI:10.1016/j.chembiol.2018.03.009  PMID:29681525  PMCID:PMC6014907
    • Cistrone, P. A., Silvestri, A. P., Hintzen, J. C. J., Dawson, P. E. Rigid peptide macrocycles from on-resin glaser stapling ChemBioChem  2018 19:1031-1035  DOI:10.1002/cbic.201800121  PMID:29516601
    • Liew, S. K., Holownia, A., Diaz, D. B., Cistrone, P. A., Dawson, P. E., Yudin, A. K. Borylated oximes: versatile building blocks for organic synthesis Chemical Communications  2017 53:11237-11240  DOI:10.1039/c7cc06579e  PMID:28959806
    • Susumu, K., Field, L. D., Oh, E., Hunt, M., Delehanty, J. B., Palomo, V., Dawson, P. E., Huston, A. L., Medintz, I. L. Purple-, blue-, and green-emitting multishell alloyed quantum dots: synthesis, characterization, and application for ratiometric extracellular pH sensing Chemistry of Materials  2017 29:7330-7344  DOI:10.1021/acs.chemmater.7b02174
    • Silvestri, A. P., Cistrone, P. A., Dawson, P. E. Adapting the glaser reaction for bioconjugation: robust access to structurally simple, rigid linkers Angewandte Chemie-International Edition  2017 56:10438-10442  DOI:10.1002/anie.201705065  PMID:28685936
    • Breger, J. C., Muttenthaler, M., Delehanty, J. B., Thompson, D. A., Oh, E., Susumu, K., Deschamps, J. R., Anderson, G. P., Field, L. D., Walper, S. A., Dawson, P. E., Medintz, I. L. Nanoparticle cellular uptake by dendritic wedge peptides: achieving single peptide facilitated delivery Nanoscale  2017 9:10447-10464  DOI:10.1039/c7nr03362a  PMID:28703833
    • Silvestri, A. P., Dawson, P. E. Base-catalyzed diastereoselective trimerization of trifluoroacetone Organic & Biomolecular Chemistry  2017 15:5131-5134  DOI:10.1039/c7ob01094j  PMID:28594047
    • Adhikary, R., Tan, Y. X., Liu, J., Zimmermann, J., Holcomb, M., Yvellez, C., Dawson, P. E., Romesberg, F. E. Conformational heterogeneity and DNA recognition by the morphogen bicoid Biochemistry  2017 56:2787-2793  DOI:10.1021/acs.biochem.7b00255  PMID:28547993
    • Nag, O. K., Stewart, M. H., Deschamps, J. R., Susumu, K., Oh, E., Tsytsarev, V., Tang, Q. G., Efros, A. L., Vaxenburg, R., Black, B. J., Chen, Y. C., O'Shaughnessy, T. J., et al. Quantum dot-peptide-fullerene bioconjugates for visualization of in vitro and in vivo cellular membrane potential ACS Nano  2017 11:5598-5613  DOI:10.1021/acsnano.7b00954  PMID:28514167
    • Matthews, M. L., He, L., Horning, B. D., Olson, E. J., Correia, B. E., Yates III, J. R., Dawson, P. E., Cravatt, B. F. Chemoproteomic profiling and discovery of protein electrophiles in human cells Nature Chemistry  2017 9:234-243  DOI:10.1038/nchem.2645  PMID:28221344  PMCID:PMC5325178
    • Algar, W. R., Khachatrian, A., Melinger, J. S., Huston, A. L., Stewart, M. H., Susumu, K., Blanco-Canosa, J. B., Oh, E., Dawson, P. E., Medintz, I. L. Concurrent modulation of quantum dot photoluminescence using a combination of charge transfer and Forster resonance energy transfer: competitive quenching and multiplexed biosensing modality Journal of the American Chemical Society  2017 139:363-372  DOI:10.1021/jacs.6b11042  PMID:28009161
    • Getz, T., Qin, J., Medintz, I. L., Delehanty, J. B., Susumu, K., Dawson, P. E., Dawson, G. Quantum dot-mediated delivery of siRNA to inhibit sphingomyelinase activities in brain-derived cells Journal of Neurochemistry  2016 139:872-885  DOI:10.1111/jnc.13841  PMID:27622309
    • Olson, E. J., Lechtenberg, B. C., Zhao, C., Rubio de la Torre, E., Lamberto, I., Riedl, S. J., Dawson, P. E., Pasquale, E. B. Modifications of a nanomolar cyclic peptide antagonist for the EphA4 receptor to achieve high plasma stability ACS Medicinal Chemistry Letters  2016 7:841-846  DOI:10.1021/acsmedchemlett.6b00132  PMID:27660688  PMCID:PMC5018863
    • Palomo, V., Diaz, S. A., Stewart, M. H., Susumu, K., Medintz, I. L., Dawson, P. E. 3,4-dihydroxyphenylalanine peptides as nonperturbative quantum dot sensors of aminopeptidase ACS Nano  2016 10:6090-6099  DOI:10.1021/acsnano.6b01682  PMID:27206058  PMCID:PMC4968404
    • Thompson, D. A., Ng, R., Dawson, P. E. Arginine selective reagents for ligation to peptides and proteins Journal of Peptide Science  2016 22:311-319  DOI:10.1002/psc.2867  PMID:27005702
    • Agten, S. M., Dawson, P. E., Hackeng, T. M. Oxime conjugation in protein chemistry: from carbonyl incorporation to nucleophilic catalysis Journal of Peptide Science  2016 22:271-279  DOI:10.1002/psc.2874  PMID:27006095
    • Cistrone, P. A., Dawson, P. E. Click-based libraries of SFTI-1 peptides: new methods using reversed-phase silica ACS Combinatorial Science  2016 18:139-143  DOI:10.1021/acs.combsci.5b00195  PMID:26914614
    • Reichart, T. M., Baksh, M. M., Rhee, J. K., Fiedler, J. D., Sligar, S. G., Finn, M. G., Zwick, M. B., Dawson, P. E. Trimerization of the HIV transmembrane domain in lipid bilayers modulates broadly neutralizing antibody binding Angewandte Chemie-International Edition  2016 55:2688-2692  DOI:10.1002/anie.201508421  PMID:26799917
    • Weidmann, J., Dimitrijevic, E., Hoheisel, J. D., Dawson, P. E. Boc-SPPS: Compatible linker for the synthesis of peptide o-aminoanilides Organic Letters  2016 18:164-167  DOI:10.1021/acs.orglett.5b03111  PMID:26702477
    • Zhan, N., Palui, G., Kapur, A., Palomo, V., Dawson, P. E., Mattoussi, H. Controlling the architecture, coordination, and reactivity of nanoparticle coating utilizing an amino acid central scaffold Journal of the American Chemical Society  2015 137:16084-16097  DOI:10.1021/jacs.5b10359  PMID:26621185
    • Zhang, H., Sturchler, E., Zhu, J., Nieto, A., Cistrone, P. A., Xie, J., He, L., Yea, K., Jones, T., Turn, R., Di Stefano, P. S., Griffin, P. R., et al. Autocrine selection of a GLP-1R G-protein biased agonist with potent antidiabetic effects Nature Communications  2015 6:8918  DOI:10.1038/ncomms9918  PMID:26621478  PMCID:PMC4686834
    • Adhikary, R., Zimmermann, J., Dawson, P. E., Romesberg, F. E. Temperature Dependence of CN and SCN IR absorptions facilitates their interpretation and use as probes of proteins Analytical Chemistry  2015 87:11561-11567  DOI:10.1021/acs.analchem.5b03437  PMID:26523838
    • Gemmill, K. B., Diaz, S. A., Blanco-Canosa, J. B., Deschamps, J. R., Pons, T., Liu, H. W., Deniz, A., Melinger, J., Oh, E., Susumu, K., Stewart, M. H., Hastman Jr., D. A., et al. Examining the polyproline nanoscopic ruler in the context of quantum dots Chemistry of Materials  2015 27:6222-6237  DOI:10.1021/acs.chemmater.5b03181
    • Kong, L., Kadam, R. U., Giang, E., Ruwona, T. B., Nieusma, T., Culhane, J. C., Stanfield, R. L., Dawson, P. E., Wilson, I. A., Law, M. Structure of hepatitis C virus envelope glycoprotein E1 antigenic site 314-324 in complex with antibody IGH526 Journal of Molecular Biology  2015 427:2617-2628  DOI:10.1016/j.jmb.2015.06.012  PMID:26135247  PMCID:PMC4523428
    • Assem, N., Ferreira, D. J., Wolan, D. W., Dawson, P. E. Acetone-linked peptides: a convergent approach for peptide macrocyclization and labeling Angewandte Chemie-International Edition  2015 54:8665-8668  DOI:10.1002/anie.201502607  PMID:26096515  PMCID:PMC4824200
    • Muttenthaler, M., Albericio, F., Dawson, P. E. Methods, setup and safe handling for anhydrous hydrogen fluoride cleavage in Boc solid-phase peptide synthesis Nature Protocols  2015 10:1067-1083  DOI:10.1038/nprot.2015.061  PMID:26086408
    • Walters, R., Medintz, I. L., Delehanty, J. B., Stewart, M. H., Susumu, K., Huston, A. L., Dawson, P. E., Dawson, G. The role of negative charge in the delivery of quantum dots to neurons ASN Neuro  2015 7:pii  DOI:10.1177/1759091415592389  PMID:26243591  PMCID:PMC4550297
    • Blanco-Canosa, J. B., Nardone, B., Albericio, F., Dawson, P. E. Chemical protein synthesis using a second-generation N-acylurea linker for the preparation of peptide-thioester precursors Journal of the American Chemical Society  2015 137:7197-7209  DOI:10.1021/jacs.5b03504  PMID:25978693
    • Wang, W., Kapur, A., Ji, X., Safi, M., Palui, G., Palomo, V., Dawson, P. E., Mattoussi, H. Photoligation of an amphiphilic polymer with mixed coordination provides compact and reactive quantum dots Journal of the American Chemical Society  2015 137:5438-5451  DOI:10.1021/jacs.5b00671  PMID:25797052
    • Agarwal, R., Domowicz, M. S., Schwartz, N. B., Henry, J., Medintz, I., Delehanty, J. B., Stewart, M. H., Susumu, K., Huston, A. L., Deschamps, J. R., Dawson, P. E., Palomo, V., et al. Delivery and tracking of quantum dot peptide bioconjugates in an intact developing avian brain ACS Chemical Neuroscience  2015 6:494-504  DOI:10.1021/acschemneuro.5b00022  PMID:25688887  PMCID:PMC5056627
    • Aldeek, F., Hawkins, D., Palomo, V., Safi, M., Palui, G., Dawson, P. E., Alabugin, I., Mattoussi, H. UV and sunlight driven photoligation of quantum dots: understanding the photochemical transformation of the ligands Journal of the American Chemical Society  2015 137:2704-2714  DOI:10.1021/ja512802x  PMID:25612193
    • Olea Jr., C., Weidmann, J., Dawson, P. E., Joyce, G. F. An L-RNA aptamer that binds and inhibits RNase Chemistry & Biology  2015 22:1437-1441  DOI:10.1016/j.chembiol.2015.09.017  PMID:26590636  PMCID:PMC4656138
    • Lamberto, I., Lechtenberg, B. C., Olson, E. J., Mace, P. D., Dawson, P. E., Riedl, S. J., Pasquale, E. B. Development and structural analysis of a nanomolar cyclic peptide antagonist for the EphA4 receptor ACS Chemical Biology  2014 9:2787-2795  DOI:10.1021/cb500677x  PMID:25268696  PMCID:PMC4273976
    • Adhikary, R., Zimmermann, J., Liu, J., Forrest, R. P., Janicki, T. D., Dawson, P. E., Corcelli, S. A., Romesberg, F. E. Evidence of an unusual N-H…N hydrogen bond in proteins Journal of the American Chemical Society  2014 136:13474-13477  DOI:10.1021/ja503107h  PMID:25226114
    • Culhane, J. C., Dawson, P. E. Peptide pharmaceuticals: modifications to the peptide backbone that enhance stability and targeting Chimica Oggi-Chemistry Today  2014 32:17-20
    • Thompson, D. A., Evans, E. G. B., Kasza, T., Millhauser, G. L., Dawson, P. E. Adapter reagents for protein site specific dye labeling Biopolymers  2014 102:273-279  DOI:10.1002/bip.22481  PMID:24599728  PMCID:PMC4851436
    • Scott, A. M., Algar, W. R., Stewart, M. H., Trammell, S. A., Blanco-Canosa, J. B., Dawson, P. E., Deschamps, J. R., Goswami, R., Oh, E., Huston, A. L., Medintz, I. L. Probing the quenching of quantum dot photoluminescence by peptide-labeled ruthenium(II) complexes Journal of Physical Chemistry C  2014 118:9239-9250  DOI:10.1021/jp501039w  PMID:24817922  PMCID:PMC4010286
    • Adhikary, R., Zimmermann, J., Dawson, P. E., Romesberg, F. E. IR probes of protein microenvironments: utility and potential for perturbation ChemPhysChem  2014 15:849-853  DOI:10.1002/cphc.201400017  PMID:24519759
    • Blanco-Canosa, J. B., Wu, M., Susumu, K., Petryayeva, E., Jennings, T. L., Dawson, P. E., Algar, W. R., Medintz, I. L. Recent progress in the bioconjugation of quantum dots Coordination Chemistry Reviews  2014 263:101-137  DOI:10.1016/j.ccr.2013.08.030
    • Becker, C. F. W., Brik, A., Dawson, P., Hackenberger, C. P. R. Chemical protein synthesis Journal of Peptide Science  2014 20:63  DOI:10.1002/psc.2607  PMID:25975419
    • Wendeler, M., Grinberg, L., Wang, X., Dawson, P. E., Baca, M. Enhanced catalysis of oxime-based bioconjugations by substituted anilines Bioconjugate Chemistry  2014 25:93-101  DOI:10.1021/bc400380f  PMID:24320725
    • Koehbach, J., O'Brien, M., Muttenthaler, M., Miazzo, M., Akcan, M., Elliott, A. G., Daly, N. L., Harvey, P. J., Arrowsmith, S., Gunasekera, S., Smith, T. J., Wray, S., et al. Oxytocic plant cyclotides as templates for peptide G protein-coupled receptor ligand design Proceedings of the National Academy of Sciences of the United States of America  2013 110:21183-21188  DOI:10.1073/pnas.1311183110  PMID:24248349  PMCID:PMC3876230
    • Adhikary, R., Zimmermann, J., Liu, J., Dawson, P. E., Romesberg, F. E. Experimental characterization of electrostatic and conformational heterogeneity in an SH3 domain Journal of Physical Chemistry B  2013 117:13082-13089  DOI:10.1021/jp402772x  PMID:23834285
    • Stewart, M. H., Huston, A. L., Scott, A. M., Oh, E., Algar, W. R., Deschamps, J. R., Susumu, K., Jain, V., Prasuhn, D. E., Blanco-Canosa, J., Dawson, P. E., Medintz, I. L. Competition between Förster resonance energy transfer and electron transfer in stoichiometrically assembled semiconductor quantum dot-fullerene conjugates ACS Nano  2013 7:9489-9505  DOI:10.1021/nn403872x  PMID:24128175
    • Doyle-Cooper, C., Hudson, K. E., Cooper, A. B., Ota, T., Skog, P., Dawson, P. E., Zwick, M. B., Schief, W. R., Burton, D. R., Nemazee, D. Immune tolerance negatively regulates B cells in knock-in mice expressing broadly neutralizing HIV antibody 4E10 Journal of Immunology  2013 191:3186-3191  DOI:10.4049/jimmunol.1301285  PMID:23940276  PMCID:PMC3773228
    • Bradburne, C. E., Delehanty, J. B., Gemmill, K. B., Mei, B. C., Mattoussi, H., Susumu, K., Blanco-Canosa, J. B., Dawson, P. E., Medintz, I. L. Cytotoxicity of quantum dots used for in vitro cellular labeling: role of QD surface ligand, delivery modality, cell type, and direct comparison to organic fluorophores Bioconjugate Chemistry  2013 24:1570-1583  DOI:10.1021/bc4001917  PMID:23879393
    • Gemmill, K. B., Muttenthaler, M., Delehanty, J. B., Stewart, M. H., Susumu, K., Dawson, P. E., Medintz, I. L. Evaluation of diverse peptidyl motifs for cellular delivery of semiconductor quantum dots Analytical and Bioanalytical Chemistry  2013 405:6145-6154  DOI:10.1007/s00216-013-6982-2  PMID:23732866
    • Gemmill, K. B., Muttenthaler, M., Delehanty, J., Deschamps, J., Susumu, K., Stewart, M., Dawson, P., Huston, A., Medintz, I. Peptide-mediated cellular delivery of semiconductor quantum dots Proceedings of the SPIE  2013 8723:872311/1-872311/6  DOI:10.1117/12.2015446
    • Boeneman, K., Delehanty, J. B., Blanco-Canosa, J. B., Susumu, K., Stewart, M. H., Oh, E., Huston, A. L., Dawson, G., Ingale, S., Walters, R., Domowicz, M., Deschamps, J. R., et al. Selecting improved peptidyl motifs for cytosolic delivery of disparate protein and nanoparticle materials ACS Nano  2013 7:3778-3796  DOI:10.1021/nn400702r  PMID:23710591  PMCID:PMC3880025
    • Algar, W. R., Blanco-Canosa, J. B., Manthe, R. L., Susumu, K., Stewart, M. H., Dawson, P. E., Medintz, I. L. Synthesizing and modifying peptides for chemoselective ligation and assembly into quantum dot-peptide bioconjugates Methods in Molecular Biology  2013 1025:47-73  DOI:10.1007/978-1-62703-462-3_5  PMID:23918329
    • Delehanty, J. B., Blanco-Canosa, J. B., Bradburne, C. E., Susumu, K., Stewart, M. H., Prasuhn, D. E., Dawson, P. E., Medintz, I. L. Site-specific cellular delivery of quantum dots with chemoselectively-assembled modular peptides Chemical Communications  2013 49:7878-7880  DOI:10.1039/c3cc42781a  PMID:23759873
    • Algar, W. R., Malonoski, A., Deschamps, J. R., Banco-Canosa, J. B., Susumu, K., Stewart, M. H., Johnson, B. J., Dawson, P. E., Medintz, I. L. Proteolytic activity at quantum dot-conjugates: kinetic analysis reveals enhanced enzyme activity and localized interfacial "hopping" Nano Letters  2012 12:3793-3802  DOI:10.1021/nl301727k  PMID:22731798
    • Yu, W., Dawson, P. E., Zimmermann, J., Romesberg, F. E. Carbon-deuterium bonds as probes of protein thermal unfolding Journal of Physical Chemistry B  2012 116:6397-6403  DOI:10.1021/jp303521t  PMID:22625650
    • Stewart, M. H., Huston, A. L., Scott, A. M., Efros, A. L., Melinger, J. S., Gemmill, K. B., Trammell, S. A., Blanco-Canosa, J. B., Dawson, P. E., Medintz, I. L. Complex Förster energy transfer interactions between semiconductor quantum dots and a redox-active osmium assembly ACS Nano  2012 6:5330-5347  DOI:10.1021/nn301177h  PMID:22671940
    • Gemmill, K. B., Delehanty, J. B., Stewart, M. H., Susumu, K., Blanco-Canosa, J. B., Dawson, P. E., Huston, A., Medintz, I. Further progress in cytosolic cellular delivery of quantum dots Proceedings of the SPIE  2012 8232:82320B/1-82320B/7  DOI:10.1117/12.906801
    • Buckhout-White, S., Ancona, M., Oh, E., Deschamps, J. R., Stewart, M. H., Blanco-Canosa, J. B., Dawson, P. E., Goldman, E. R., Medintz, I. L. Multimodal characterization of a linear DNA-based nanostructure ACS Nano  2012 6:1026-1043  DOI:10.1021/nn204680r  PMID:22257317
    • Algar, W. R., Wegner, D., Huston, A. L., Blanco-Canosa, J. B., Stewart, M. H., Armstrong, A., Dawson, P. E., Hildebrandt, N., Medintz, I. L. Quantum dots as simultaneous acceptors and donors in time-gated Förster resonance energy transfer relays: characterization and biosensing Journal of the American Chemical Society  2012 134:1876-1891  DOI:10.1021/ja210162f  PMID:22220737
    • Wu, Z., Chen, K. V., Yildiz, I., Dirksen, A., Fischer, R., Dawson, P. E., Steinmetz, N. F. Development of viral nanoparticles for efficient intracellular delivery Nanoscale  2012 4:3567-3576  DOI:10.1039/c2nr30366c  PMID:22508503  PMCID:PMC3563001
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    • Stewart, M. H., Susumu, K., Mei, B. C., Medintz, I. L., Delehanty, J. B., Blanco-Canosa, J. B., Dawson, P. E., Mattoussi, H. Multidentate poly(ethylene glycol) ligands provide colloidal stability to semiconductor and metallic nanocrystals in extreme conditions Journal of the American Chemical Society  2010 132:9804-9813  DOI:10.1021/ja102898d  PMID:20578776
    • Oh, E., Susumu, K., Blanco-Canosa, J. B., Medintz, I. L., Dawson, P. E., Mattoussi, H. Preparation of stable maleimide-functionalized Au nanoparticles and their use in counting surface ligands Small  2010 6:1273-1278  DOI:10.1002/smll.201000279  PMID:20486227
    • Dawson, G., Schroeder, C., Dawson, P. E. Palmitoyl:protein thioesterase (PPT1) inhibitors can act as pharmacological chaperones in infantile Batten disease Biochemical and Biophysical Research Communications  2010 395:66-69  DOI:10.1016/j.bbrc.2010.03.137  PMID:20346914  PMCID:PMC2881699
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    • Shekhter, T., Metanis, N., Dawson, P. E., Keinan, E. A residue outside the active site CXXC motif regulates the catalytic efficiency of Glutaredoxin 3 Molecular Biosystems  2010 6:241-248  DOI:10.1039/b912753d  PMID:20024086  PMCID:PMC3820274
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    • Van de Vijver, P., Suylen, D., Dirksen, A., Dawson, P. E., Hackeng, T. M. N(epsilon)-(thiaprolyl)-lysine as a handle for site-specific protein conjugation Biopolymers  2010 94:465-474  DOI:10.1002/bip.21485  PMID:20593461
    • Erlich, L. A., Kumar, K. S. A., Haj-Yahya, M., Dawson, P. E., Brik, A. N-methylcysteine-mediated total chemical synthesis of ubiquitin thioester Organic & Biomolecular Chemistry  2010 8:2392-2396  DOI:10.1039/c000332h  PMID:20448897  PMCID:PMC3183995
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    • Metanis, N., Keinan, E., Dawson, P. E. Traceless ligation of cysteine peptides using selective deselenization Angewandte Chemie-International Edition  2010 49:7049-7053  DOI:10.1002/anie.201001900  PMID:20715234  PMCID:PMC4459706
    • Vanacore, R., Ham, A. J. L., Voehler, M., Sanders, C. R., Conrads, T. P., Veenstra, T. D., Sharpless, K. B., Dawson, P. E., Hudson, B. G. A sulfilimine bond identified in collagen IV Science  2009 325:1230-1234  DOI:10.1126/science.1176811  PMID:19729652  PMCID:PMC2876822
    • Pejchal, R., Gach, J. S., Brunel, F. M., Cardoso, R. M., Stanfield, R. L., Dawson, P. E., Burton, D. R., Zwick, M. B., Wilson, I. A. A conformational switch in human immunodeficiency virus gp41 revealed by the structures of overlapping epitopes recognized by neutralizing antibodies Journal of Virology  2009 83:8451-8462  DOI:10.1128/jvi.00685-09  PMID:19515770  PMCID:PMC2738203
    • Medintz, I. L., Farrell, D., Susumu, K., Trammell, S. A., Deschamps, J. R., Brunel, F. M., Dawson, P. E., Mattoussi, H. Multiplex charge-transfer interactions between quantum dots and peptide-bridged ruthenium complexes Analytical Chemistry  2009 81:4831-4839  DOI:10.1021/ac900412j  PMID:19445483
    • Tiefenbrunn, T. K., Dawson, P. E. Chemical synthesis and biotinylation of the thrombospondin domain TSR2 Protein Science  2009 18:970-979  DOI:10.1002/pro.107  PMID:19384999  PMCID:PMC2771299
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    • Thielges, M. C., Zimmermann, J., Dawson, P. E., Romesberg, F. E. The determinants of stability and folding in evolutionarily diverged cytochromes c Journal of Molecular Biology  2009 388:159-167  DOI:10.1016/j.jmb.2009.02.059  PMID:19268474  PMCID:PMC2990880
    • Kraut, D. A., Churchill, M. J., Dawson, P. E., Herschlag, D. Evaluating the potential for halogen bonding in the oxyanion hole of ketosteroid isomerase using unnatural amino acid mutagenesis ACS Chemical Biology  2009 4:269-273  DOI:10.1021/cb900016q  PMID:19260691  PMCID:PMC2708088
    • Zeng, Y., Ramya, T. N. C., Dirksen, A., Dawson, P. E., Paulson, J. C. High-efficiency labeling of sialylated glycoproteins on living cells Nature Methods  2009 6:207-209  DOI:10.1038/nmeth.1305  PMID:19234450  PMCID:PMC2830088
    • Weinkam, P., Zimmermann, J., Sagle, L. B., Matsuda, S., Dawson, P. E., Wolynes, P. G., Romesberg, F. E. Characterization of alkaline transitions in ferricytochrome c using carbon-deuterium infrared probes Biochemistry  2008 47:13470-13480  DOI:10.1021/bi801223n  PMID:19035653  PMCID:PMC2853379
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    • Dirksen, A., Dawson, P. E. Rapid oxime and hydrazone ligations with aromatic aldehydes for biomolecular labeling Bioconjugate Chemistry  2008 19:2543-2548  DOI:10.1021/bc800310p  PMID:19053314  PMCID:PMC2761707
    • Yegneswaran, S., Hackeng, T. M., Dawson, P. E., Griffin, J. H. The thrombin-sensitive region of protein S mediates phospholipid-dependent interaction with factor Xa Journal of Biological Chemistry  2008 283:33046-33052  DOI:10.1074/jbc.M806527200  PMID:18784085  PMCID:PMC2586267
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    • Nelson, J. D., Kinkead, H., Brunel, F. M., Leaman, D., Jensen, R., Louis, J. M., Maruyama, T., Bewley, C. A., Bowdish, K., Clore, G. M., Dawson, P. E., Frederickson, S., et al. Antibody elicited against the gp41 N-heptad repeat (NHR) coiled-coil can neutralize HIV-1 with modest potency but non-neutralizing antibodies also bind to NHR mimetics Virology  2008 377:170-183  DOI:10.1016/j.virol.2008.04.005  PMID:18499210  PMCID:PMC2493441
    • Yamamoto, N., Tanabe, Y., Okamoto, R., Dawson, P. E., Kajihara, Y. Chemical synthesis of a glycoprotein having an intact human complex-type sialyloligosaccharide under the Boc and Fmoc synthetic strategies Journal of the American Chemical Society  2008 130:501-510  DOI:10.1021/ja072543f  PMID:18085777
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    • Xu, Y., Hixon, M. S., Dawson, P. E., Janda, K. D. Development of a FRET assay for monitoring of HIV gp41 core disruption Journal of Organic Chemistry  2007 72:6700-6707  DOI:10.1021/jo070836l  PMID:17685571
    • Sapsford, K. E., Pons, T., Medintz, I. L., Higashiya, S., Brunel, F. M., Dawson, P. E., Mattoussi, H. Kinetics of metal-affinity driven self-assembly between proteins or peptides and CdSe-ZnS quantum dots Journal of Physical Chemistry C  2007 111:11528-11538  DOI:10.1021/jp073550t
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    • Metanis, N., Keinan, E., Dawson, P. E. Synthetic seleno-glutaredoxin 3 analogues are highly reducing oxidoreductases with enhanced catalytic efficiency Journal of the American Chemical Society  2006 128:16684-16691  DOI:10.1021/ja0661414  PMID:17177418  PMCID:PMC2532977
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    • Cremeens, M. E., Fujisaki, H., Zhang, Y., Zimmermann, J., Sagle, L. B., Matsuda, S., Dawson, P. E., Straub, J. E., Romesberg, F. E. Efforts toward developing direct probes of protein dynamics Journal of the American Chemical Society  2006 128:6028-6029  DOI:10.1021/ja061328g  PMID:16669659
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    • Neuman, B. W., Stein, D. A., Kroeker, A. D., Churchill, M. J., Kim, A. M., Kuhn, P., Dawson, P., Moulton, H. M., Bestwick, R. K., Iversen, P. L., Buchmeier, M. J. Inhibition, escape, and attenuated growth of severe acute respiratory syndrome coronavirus treated with antisense morpholino oligomers Journal of Virology  2005 79:9665-9676  DOI:10.1128/jvi.79.15.9665-9676.2005  PMID:16014928  PMCID:PMC1181598
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    • Metanis, N., Brik, A., Dawson, P. E., Keinan, E. Electrostatic interactions dominate the catalytic contribution of Arg39 in 4-oxalocrotonate tautomerase Journal of the American Chemical Society  2004 126:12726-12727  DOI:10.1021/ja0463841  PMID:15469238
    • Deechongkit, S., Nguyen, H., Powers, E. T., Dawson, P. E., Gruebele, M., Kelly, J. W. Context-dependent contributions of backbone hydrogen bonding to β-sheet folding energetics Nature  2004 430:101-105  DOI:10.1038/nature02611  PMID:15229605
    • Kamikubo, Y., De Guzman, R., Kroon, G., Curriden, S., Neels, J. G., Churchill, M. J., Dawson, P., Oldziej, S., Jagielska, A., Scheraga, H. A., Loskutoff, D. J., Dyson, H. J. Disulfide bonding arrangements in active forms of the somatomedin B domain of human vitronectin Biochemistry  2004 43:6519-6534  DOI:10.1021/bi049647c  PMID:15157085
    • Marinzi, C., Offer, J., Longhi, R., Dawson, P. E. An o-nitrobenzyl scaffold for peptide ligation: synthesis and applications Bioorganic & Medicinal Chemistry  2004 12:2749-2757  DOI:10.1016/j.bmc.2004.02.039  PMID:15110856
    • Sagle, L. B., Zimmermann, J., Dawson, P. E., Romesberg, F. E. A high-resolution probe of protein folding Journal of the American Chemical Society  2004 126:3384-3385  DOI:10.1021/ja049890z  PMID:15025440
    • Bayro, M. J., Mukhopadhyay, J., Swapna, G. V. T., Huang, J. Y., Ma, L. C., Sineva, E., Dawson, P. E., Montelione, G. T., Ebright, R. H. Structure of antibacterial peptide microcin J25: a 21-residue lariat protoknot Journal of the American Chemical Society  2003 125:12382-12383  DOI:10.1021/ja036677e  PMID:14531661
    • Zwick, M. B., Parren, P. W., Saphire, E. O., Church, S., Wang, M., Scott, J. K., Dawson, P. E., Wilson, I. A., Burton, D. R. Molecular features of the broadly neutralizing immunoglobulin G1 b12 required for recognition of human immunodeficiency virus type 1 gp120 Journal of Virology  2003 77:5863-5876  DOI:10.1128/jvi.77.10.5863-5876.2003  PMID:12719580  PMCID:PMC154005
    • Blankenship, J. W., Dawson, P. E. Thermodynamics of a designed protein catenane Journal of Molecular Biology  2003 327:537-548  DOI:10.1016/s0022-2836(03)00115-3  PMID:12628256
    • Blankenship, J. W., Balambika, R., Dawson, P. E. Probing backbone hydrogen bonds in the hydrophobic core of GCN4 Biochemistry  2002 41:15676-15684  DOI:10.1021/bi026862p  PMID:12501196
    • Dawson, G., Dawson, S. A., Marinzi, C., Dawson, P. E. Anti-tumor promoting effects of palmitoyl: protein thioesterase inhibitors against a human neurotumor cell line Cancer Letters  2002 187:163-168  DOI:10.1016/s0304-3835(02)00403-2  PMID:12359364
    • Brik, A., Dawson, P. E., Keinan, E. The product of the natural reaction catalyzed by 4-oxalocrotonate tautomerase becomes an affinity label of its mutant Bioorganic & Medicinal Chemistry  2002 10:3891-3897  DOI:10.1016/s0968-0896(02)00385-1  PMID:12413840
    • Brik, A., D'Souza, L. J., Keinan, E., Grynszpan, F., Dawson, P. E. Mutants of 4-oxalocrotonate tautomerase catalyze the decarboxylation of oxaloacetate through an imine mechanism ChemBioChem  2002 3:845-851  DOI:10.1002/1439-7633(20020902)3:9<845::aid-cbic845>3.0.co;2-2  PMID:12210985
    • Marx, P. F., Dawson, P. E., Bouma, B. N., Meijers, J. C. M. Plasmin-mediated activation and inactivation of thrombin-activatable fibrinolysis inhibitor Biochemistry  2002 41:6688-6696  DOI:10.1021/bi015982e  PMID:12022872
    • Offer, J., Boddy, C. N. C., Dawson, P. E. Extending synthetic access to proteins with a removable acyl transfer auxiliary Journal of the American Chemical Society  2002 124:4642-4646  DOI:10.1021/ja016731w  PMID:11971712
    • Yegneswaran, S., Fernandez, J. A., Griffin, J. H., Dawson, P. E. Factor Va increases the affinity of factor Xa for prothrombin: a binding study using a novel photoactivable thiol-specific fluorescent probe Chemistry & Biology  2002 9:485-494  DOI:10.1016/s1074-5521(02)00132-1  PMID:11983337
    • Marinzi, C., Bark, S. J., Offer, J., Dawson, P. E. A new scaffold for amide ligation Bioorganic & Medicinal Chemistry  2001 9:2323-2328  DOI:10.1016/s0968-0896(01)00136-5  PMID:11553471
    • Yan, L. Z., Dawson, P. E. Synthesis of peptides and proteins without cysteine residues by native chemical ligation combined with desulfurization Journal of the American Chemical Society  2001 123:526-533  DOI:10.1021/ja003265m  PMID:11456564
    • Yan, L. Z., Dawson, P. E. Design and synthesis of a protein catenane Angewandte Chemie-International Edition  2001 40:3625-3627  DOI:10.1002/1521-3773(20011001)40:19<3625::aid-anie3625>3.0.co;2-q  PMID:11592201
    • Hackeng, T. M., Fernandez, J. A., Dawson, P. E., Kent, S. B. H., Griffin, J. H. Chemical synthesis and spontaneous folding of a multidomain protein: anticoagulant microprotein S Proceedings of the National Academy of Sciences of the United States of America  2000 97:14074-14078  DOI:10.1073/pnas.260239797  PMID:11106381  PMCID:PMC18873
    • Beligere, G. S., Dawson, P. E. Design, synthesis, and characterization of 4-ester CI2, a model for backbone hydrogen bonding in protein α-helices Journal of the American Chemical Society  2000 122:12079-12082  DOI:10.1021/ja001648e
    • Cho, S. G., Dawson, P. E., Dawson, G. Antisense palmitoyl protein thioesterase 1 (PPT1) treatment inhibits PPT1 activity and increases cell death in LA-N-5 neuroblastoma cells Journal of Neuroscience Research  2000 62:234-240  DOI:10.1002/1097-4547(20001015)62:2<234::aid-jnr8>3.0.co;2-8  PMID:11020216
    • Pelletier, A. J., van der Laan, L. J. W., Hildbrand, P., Siani, M. A., Thompson, D. A., Dawson, P. E., Torbett, B. E., Salomon, D. R. Presentation of chemokine SDF-1α by fibronectin mediates directed migration of T cells Blood  2000 96:2682-2690  PMID:11023498
    • Beck, Z. Q., Hervio, L., Dawson, P. E., Elder, J. H., Madison, E. L. Identification of efficiently cleaved substrates for HIV-1 protease using a phage display library and use in inhibitor development Virology  2000 274:391-401  DOI:10.1006/viro.2000.0420  PMID:10964781
    • Brik, A., Keinan, E., Dawson, P. E. Protein synthesis by solid-phase chemical ligation using a safety catch linker Journal of Organic Chemistry  2000 65:3829-3835  DOI:10.1021/jo000346s  PMID:10864771
    • King, C. C., Zenke, F. T., Dawson, P. E., Dutil, E. M., Newton, A. C., Hemmings, B. A., Bokoch, G. M. Sphingosine is a novel activator of 3-phosphoinositide-dependent kinase 1 Journal of Biological Chemistry  2000 275:18108-18113  DOI:10.1074/jbc.M909663199  PMID:10748151
    • Deniz, A. A., Laurence, T. A., Beligere, G. S., Dahan, M., Martin, A. B., Chemla, D. S., Dawson, P. E., Schultz, P. G., Weiss, S. Single-molecule protein folding: diffusion fluorescence resonance energy transfer studies of the denaturation of chymotrypsin inhibitor 2 Proceedings of the National Academy of Sciences of the United States of America  2000 97:5179-5184  DOI:10.1073/pnas.090104997  PMID:10792044  PMCID:PMC25802
    • Marx, P. F., Hackeng, T. M., Dawson, P. E., Griffin, J. H., Meijers, J. C. M., Bouma, B. N. Inactivation of active thrombin-activable fibrinolysis inhibitor takes place by a process that involves conformational instability rather than proteolytic cleavage Journal of Biological Chemistry  2000 275:12410-12415  DOI:10.1074/jbc.275.17.12410  PMID:10777524
    • Cho, S. G., Dawson, P. E., Dawson, G. In vitro depalmitoylation of neurospecific peptides: implication for infantile neuronal ceroid lipofuscinosis Journal of Neuroscience Research  2000 59:32-38  DOI:10.1002/(sici)1097-4547(20000101)59:1<32::aid-jnr5>3.0.co;2-a  PMID:10658183
    • Offer, J., Dawson, P. E. N-alpha-2-mercaptobenzylamine-assisted chemical ligation Organic Letters  2000 2:23-26  DOI:10.1021/ol991184t  PMID:10814236
    • Dawson, P. E., Kent, S. B. H. Synthesis of native proteins by chemical ligation Annual Review of Biochemistry  2000 69:923-960  DOI:10.1146/annurev.biochem.69.1.923  PMID:10966479
    • Hackeng, T. M., Griffin, J. H., Dawson, P. E. Protein synthesis by native chemical ligation: expanded scope by using straightforward methodology Proceedings of the National Academy of Sciences of the United States of America  1999 96:10068-10073  DOI:10.1073/pnas.96.18.10068  PMID:10468563  PMCID:PMC17843
    • Coombs, G. S., Rao, M. S., Olson, A. J., Dawson, P. E., Madison, E. L. Revisiting catalysis by chymotrypsin family serine proteases using peptide substrates and inhibitors with unnatural main chains Journal of Biological Chemistry  1999 274:24074-24079  DOI:10.1074/jbc.274.34.24074  PMID:10446178
    • Beligere, G. S., Dawson, P. E. Conformationally assisted protein ligation using C-terminal thioester peptides Journal of the American Chemical Society  1999 121:6332-6333  DOI:10.1021/ja9907919
    • Beligere, G. S., Dawson, P. E. Synthesis of a three zinc finger protein, Zif268, by native chemical ligation Biopolymers  1999 51:363-369  DOI:10.1002/(sici)1097-0282(1999)51:5<363::aid-bip6>3.3.co;2-f  PMID:10685047
    • Hackeng, T. M., Dawson, P. E., Kent, S. B. H., Griffin, J. H. Chemical synthesis of human protein S thrombin-sensitive module and first epidermal growth factor module Biopolymers  1998 46:53-63  DOI:10.1002/(sici)1097-0282(199808)46:2<53::aid-bip1>3.3.co;2-6  PMID:9664841
    • degree-related publication Dawson, P. E., Fitzgerald, M. C., Muir, T. W., Kent, S. B. H. Methods for the chemical synthesis and readout of self-encoded arrays of polypeptide analogues Journal of the American Chemical Society  1997 119:7917-7927  DOI:10.1021/ja963122t
    • degree-related publication Dawson, P. E., Churchill, M. J., Ghadiri, M. R., Kent, S. B. H. Modulation of reactivity in native chemical ligation through the use of thiol additives Journal of the American Chemical Society  1997 119:4325-4329  DOI:10.1021/ja962656r
    • degree-related publication Muir, T. W., Dawson, P. E., Fitzgerald, M. C., Kent, S. B. H. Protein signature analysis: a practical new approach for studying structure-activity relationships in peptides and proteins Methods in Enzymology  1997 289:545-564  DOI:10.1016/S0076-6879(97)89063-5  PMID:9353737
    • degree-related publication Muir, T. W., Dawson, P. E., Kent, S. B. H. Protein synthesis by chemical ligation of unprotected peptides in aqueous solution Methods in Enzymology  1997 289:266-298  DOI:10.1016/S0076-6879(97)89052-0  PMID:9353726
    • Dawson, P. E. Synthesis of chemokines by native chemical ligation Methods in Enzymology  1997 287:34-45  DOI:10.1016/S0076-6879(97)87005-X  PMID:9330313
    • degree-related publication Hackeng, T. M., Mounier, C. M., Bon, C., Dawson, P. E., Griffin, J. H., Kent, S. B. H. Total chemical synthesis of enzymatically active human type II secretory phospholipase A2 Proceedings of the National Academy of Sciences of the United States of America  1997 94:7845-7850  DOI:10.1073/pnas.94.15.7845  PMID:9223275  PMCID:PMC21517
    • degree-related publication Muir, T. W., Dawson, P. E., Fitzgerald, M. C., Kent, S. B. H. Probing the chemical basis of binding activity in an SH3 domain by protein signature analysis Chemistry & Biology  1996 3:817-825  DOI:10.1016/s1074-5521(96)90067-8  PMID:8939700
    • degree-related publication Bruick, R. K., Dawson, P. E., Kent, S. B., Usman, N., Joyce, G. F. Template-directed ligation of peptides to oligonucleotides Chemistry & Biology  1996 3:49-56  DOI:10.1016/s1074-5521(96)90084-8  PMID:8807828
    • degree-related publication Dawson, P. E., Muir, T. W., Clark-Lewis, I., Kent, S. B. H. Synthesis of proteins by native chemical ligation Science  1994 266:776-779  DOI:10.1126/science.7973629  PMID:7973629
    • degree-related publication Dawson, P. E., Kent, S. B. H. Convenient total synthesis of a 4-helix TASP molecule by chemoselective ligation Journal of the American Chemical Society  1993 115:7263-7266  DOI:10.1021/ja00069a027
  • chapter

    • Chemical synthesis of proteins and large bioconjugates Chemical biology : from small molecules to systems biology and drug design. 567-592. 2008  DOI:10.1002/9783527619375.ch10b
    • Dawson, P. E., Offer, J. Protein synthesis on solid support Science of Synthesis. 713-714. 2003
  • thesis

    • Deciphering the molecular basis of protein function through chemical synthesis 1996

featured in

  • Philip E. Dawson Named 2011 Max-Bergmann Medalist   Newsletter
  • Scripps Research Institute Study Explores Barriers to HIV Vaccine Response  News Release
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Research

research overview

  • Development & Utilization of Methods to Incorporate Unnatural Chemical Groups into Proteins

    We have developed a chemical approach for the production of the large polypeptide chains that comprise protein molecules, enabling us to change the structure of a protein in ways impossible by natural means. We use solid phase peptide synthesis to generate peptides up to ~50 amino acids in length and then assemble them using chemoselective reactions to make proteins up to ~150 amino acids in length. This—chemical ligation—approach greatly facilitates the synthesis of proteins of moderate size and has opened the world of proteins to the synthetic tools of organic chemistry. Chemical ligation can be extended to biologically expressed proteins enabling the semisynthesis of proteins of unlimited size that contain fluorophores or cross-linking agents at defined positions. Our goal is to introduce non-coded amino acids and other chemical groups into proteins to better understand the molecular basis of protein function.

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Teaching

advisees

  • graduate advising relationship

    • Dawson, Philip (Faculty Member) advising Yan, Nicholas 2018 -
    • Adams, Zoe Chantelle, Ph.D.  candidate, 2019 -
    • Bird, Michael, Ph.D.  candidate, 2017 -
    • Flood, Dillon, Ph.D.  candidate, 2017 -
    • Yoon, Leonard, Ph.D.  candidate, 2019 -
    • Cistrone, Philip A., Ph.D.  candidate, 2014 - 2019
    • Silvestri, Anthony Paul, Ph.D.  candidate, 2013 - 2018
    • Olson, Erika, Ph.D.  candidate, 2013 - 2017
    • Reichart, Timothy Matthias, Ph.D.  candidate, 2008 - 2014
    • Tiefenbrunn Sample, Theresa, Ph.D.  candidate, 2005 - 2009
    • Blankenship, John, Ph.D.  candidate, 1998 - 2003
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Background

education and training

  • Ph.D. in Macromolecular and Cellular Structure and Chemistry, Scripps Research 1992 - 1996
  • A.B. in Chemistry, Washington University in St. Louis , magna cum laude 1988 - 1992

awards and honors

  • Max-Bergmann Medal, conferred by Max-Bergmann-Kreis, 2011
  • The Vincent du Vigneaud Award, conferred by American Peptide Society, 2010
  • Alfred P. Sloan Research Fellow, conferred by Alfred P. Sloan Foundation, 2001 - 2003

advisee of

  • graduate advising relationship

    • Kent, Stephen B. H., Ph.D.  candidacy, 1993 - 1996
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Contact

full name

  • Philip Edward Dawson

geographic location

  • Scripps California 

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