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D'Lima, Darryl
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D'Lima, Darryl

Faculty Member
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Positions

  • 2017 - Professor, Molecular Medicine , Scripps Research
  • 2001 - Director, Orthopaedic Research Laboratories (La Jolla), Scripps Clinic , Scripps Health
  • 2017 Associate Professor of Molecular Medicine, Molecular Medicine , Scripps Research
  • 2012 - 2017 Associate Professor of Molecular Medicine, Molecular and Experimental Medicine (MEM) , Scripps Research
  • 2005 - 2012 Assistant Professor, Division of Arthritis Research, Scripps Research
  • 1998 - 2012 Assistant Professor of Molecular Medicine, Molecular and Experimental Medicine (MEM) , Scripps Research
  • 1996 - 2001 Head, Joint Mechanics Laboratory (La Jolla), Scripps Clinic , Scripps Health
  • 1998 - 2000 Adjunct Assistant Professor, Division of Arthritis Research , Scripps Research
  • 1994 - 1996 Orthopaedic Research Fellow (La Jolla), Scripps Clinic , Scripps Health

Research Areas research areas

  • Musculoskeletal Research

Contact

  • ddlima@scripps.edu

Websites

  • Darryl D'Lima, M.D.
  • Publications
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Publications

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  • 53

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    • Celik, H., Chauhan, A., Flores-Hernandez, C., Dorthe, E., D'Lima, D., Hoenecke, H. Sagittal orientation of coracoclavicular ligament reconstruction affects the stability of surgical repair Journal of Shoulder and Elbow Surgery  2020 29:1901-1911  DOI:10.1016/j.jse.2019.11.034  PMID:32197809
    • Kim, Y. M., D'Lima, D. D., Joo, Y. B., Park, I. Huge intrameniscal cyst successfully treated by open debridement and combined arthroscopic and open repair: A case report BMC Musculoskeletal Disorders  2020 21  DOI:10.1186/s12891-020-03218-0  PMID:32220248  PMCID:PMC7102424
    • Jerban, S., Lu, X., Dorthe, E. W., Alenezi, S., Ma, Y., Kakos, L., Jang, H., Sah, R. L., Chang, E. Y., D'Lima, D., Du, J. Correlations of cortical bone microstructural and mechanical properties with water proton fractions obtained from ultrashort echo time (UTE) MRI tricomponent T2*model NMR in Biomedicine  2020  DOI:10.1002/nbm.4233  PMID:31820518
    • Pegg, E. C., Walter, J., D'Lima, D. D., Fregly, B. J., Gill, H. S., Murray, D. W. Minimising tibial fracture after unicompartmental knee replacement: A probabilistic finite element study Clinical Biomechanics  2020 73:46-54  DOI:10.1016/j.clinbiomech.2019.12.014  PMID:31935599
    • Lee, K. I., Choi, S., Matsuzaki, T., Alvarez-Garcia, O., Olmer, M., Grogan, S. P., D'Lima, D. D., Lotz, M. K. FOXO1 and FOXO3 transcription factors have unique functions in meniscus development and homeostasis during aging and osteoarthritis Proceedings of the National Academy of Sciences of the United States of America  2020 117:3135-3143  DOI:10.1073/pnas.1918673117  PMID:31980519  PMCID:PMC7022148
    • D'Lima, D. D. CORR Insights®: Are TKA Kinematics During Closed Kinetic Chain Exercises Associated With Patient-reported Outcomes? A Preliminary Analysis Clinical Orthopaedics and Related Research  2020 478:264-265  DOI:10.1097/corr.0000000000001061  PMID:31794481
    • Grogan, S. P., Baek, J., D'Lima, D. D. Meniscal tissue repair with nanofibers: future perspectives Nanomedicine  2020  DOI:10.2217/nnm-2020-0183  PMID:32975146
    • D'Lima, D. P., Huang, P., Suryanarayan, P., Rosen, A., D'Lima, D. D. Tibial tray rotation and posterior slope increase risk for outliers in coronal alignment Bone & Joint Journal  2020 102B:43-48  DOI:10.1302/0301-620x.102b6.Bjj-2019-1533.R1  PMID:32475266
    • Baek, J., Lee, E., Lotz, M. K., D'Lima, D. D. Bioactive proteins delivery through core-shell nanofibers for meniscal tissue regeneration Nanomedicine-Nanotechnology Biology and Medicine  2020 23  DOI:10.1016/j.nano.2019.102090  PMID:31493556  PMCID:PMC6911641
    • Baek, J., Lotz, M. K., D'Lima, D. D. Core-shell nanofibrous scaffolds for repair of meniscus tears Tissue Engineering Part A  2019  DOI:10.1089/ten.tea.2018.0319  PMID:30950316
    • Kebbach, M., Grawe, R., Geier, A., Winter, E., Bergschmidt, P., Kluess, D., D'Lima, D., Woernle, C., Bader, R. Effect of surgical parameters on the biomechanical behaviour of bicondylar total knee endoprostheses - A robot-assisted test method based on a musculoskeletal model Scientific Reports  2019 9  DOI:10.1038/s41598-019-50399-3  PMID:31601894  PMCID:PMC6787084
    • Gaul, F., Bugbee, W. D., Hoenecke, H. R., D'Lima, D. D. A review of commercially available point-of-care devices to concentrate bone marrow for the treatment of osteoarthritis and focal cartilage lesions Cartilage  2019 10:387-394  DOI:10.1177/1947603518768080  PMID:29652173  PMCID:PMC6755874
    • Samiezadeh, S., Bougherara, H., Abolghasemian, M., D'Lima, D., Backstein, D. Rotating hinge knee causes lower bone-implant interface stress compared to constrained condylar knee replacement Knee Surgery Sports Traumatology Arthroscopy  2019 27:1224-1231  DOI:10.1007/s00167-018-5054-8  PMID:30039293
    • Chen, B., Cheng, X., Dorthe, E. W., Zhao, Y., D'Lima, D., Bydder, G. M., Liu, S., Du, J., Ma, Y. J. Evaluation of normal cadaveric Achilles tendon and enthesis with ultrashort echo time (UTE) magnetic resonance imaging and indentation testing NMR in Biomedicine  2019 32  DOI:10.1002/nbm.4034
    • Jerban, S., Ma, Y., Nazaran, A., Dorthe, E. W., Cory, E., Carl, M., D'Lima, D., Sah, R. L., Chang, E. Y., Du, J. Detecting stress injury (fatigue fracture) in fibular cortical bone using quantitative ultrashort echo time-magnetization transfer (UTE-MT): An ex vivo study Nmr in Biomedicine  2018 31  DOI:10.1002/nbm.3994  PMID:30059184
    • Geier, A., Aschemann, H., D'Lima, D., Woernle, C., Bader, R. Force closure mechanism modeling for musculoskeletal multibody simulation IEEE Transactions on Biomedical Engineering  2018 65:2482-2493  DOI:10.1109/tbme.2018.2800293  PMID:29993490
    • Lee, K. I., Olmer, M., Baek, J., D'Lima, D. D., Lotz, M. K. Platelet-derived growth factor-coated decellularized meniscus scaffold for integrative healing of meniscus tears Acta Biomaterialia  2018 76:126-134  DOI:10.1016/j.actbio.2018.06.021  PMID:29908335  PMCID:PMC6090559
    • Grogan, S. P., Duffy, S. F., Pauli, C., Lotz, M. K., D'Lima, D. D. Gene expression profiles of the meniscus avascular phenotype: A guide for meniscus tissue engineering Journal of Orthopaedic Research  2018 36:1947-1958  DOI:10.1002/jor.23864  PMID:29411909
    • Nielsen, E. S., Hsu, A., Patil, S., Colwell, C. W., D'Lima, D. D. Second-generation electronic ligament balancing for knee arthroplasty: a cadaver study Journal of Arthroplasty  2018 33:2293-2300  DOI:10.1016/j.arth.2018.02.057  PMID:29555494
    • Lee, K. I., Lee, J. S., Kang, K. T., Shim, Y. B., Kim, Y. S., Jang, J. W., Moon, S. H., D'Lima, D. D. In vitro and in vivo performance of tissue-engineered tendons for anterior cruciate ligament reconstruction American Journal of Sports Medicine  2018 46:1641-1649  DOI:10.1177/0363546518759729  PMID:29578751
    • Taniguchi, N., D'Lima, D. D., Suenaga, N., Chosa, E. A new scale measuring translation of the humeral head as a prognostic factor for the treatment of large and massive rotator cuff tears Journal of Shoulder and Elbow Surgery  2018 27:196-203  DOI:10.1016/j.jse.2017.08.026  PMID:29056484
    • Baek, J., Sovani, S., Choi, W., Jin, S., Grogan, S. P., D'Lima, D. D. Meniscal tissue engineering using aligned collagen fibrous scaffolds: comparison of different human cell sources Tissue Engineering Part A  2018 24:81-93  DOI:10.1089/ten.tea.2016.0205  PMID:28463545  PMCID:PMC5770095
    • Taniguchi, N., D'Lima, D. D., Suenaga, N., Ishida, Y., Lee, D., Goya, I., Chosa, E. Translation of the humeral head scale is associated with success of rotator cuff repair for large-massive tears BMC Musculoskeletal Disorders  2017 18  DOI:10.1186/s12891-017-1874-9  PMID:29202746  PMCID:PMC5715556
    • Meckes, J. K., Carames, B., Olmer, M., Kiosses, W. B., Grogan, S. P., Lotz, M. K., D'Lima, D. D. Compromised autophagy precedes meniscus degeneration and cartilage damage in mice Osteoarthritis and Cartilage  2017 25:1880-1889  DOI:10.1016/j.joca.2017.07.023  PMID:28801209  PMCID:PMC5650923
    • Geier, A., Kluess, D., Grawe, R., Herrmann, S., D'Lima, D., Woernle, C., Bader, R. Dynamical analysis of dislocation-associated factors in total hip replacements by hardware-in-the-loop simulation Journal of Orthopaedic Research  2017 35:2557-2566  DOI:10.1002/jor.23549  PMID:28233341
    • Mouser, V. H. M., Levato, R., Bonassar, L. J., D'Lima, D. D., Grande, D. A., Klein, T. J., Saris, D. B. F., Zenobi-Wong, M., Gawlitta, D., Malda, J. Three-dimensional bioprinting and its potential in the field of articular cartilage regeneration Cartilage  2017 8:327-340  DOI:10.1177/1947603516665445  PMID:28934880  PMCID:PMC5613889
    • D'Lima, D. D., Colwell, C. W. Intraoperative measurements and tools to assess stability Journal of the American Academy of Orthopaedic Surgeons  2017 25:S29-S32  DOI:10.5435/jaaos-d-16-00629  PMID:27941414
    • Grogan, S. P., Pauli, C., Lotz, M. K., D'Lima, D. D. Relevance of meniscal cell regional phenotype to tissue engineering Connective Tissue Research  2017 58:259-270  DOI:10.1080/03008207.2016.1268604  PMID:27925477  PMCID:PMC5433889
    • Choi, J. Y., Biswas, R., Bae, W. C., Healey, R., Im, M., Statum, S., Chang, E. Y., Du, J., Bydder, G. M., D'Lima, D., Chung, C. B. Thickness of the meniscal lamellar layer: correlation with indentation stiffness and comparison of normal and abnormally thick layers by using multiparametric ultrashort echo time MR imaging Radiology  2016 280:161-168  DOI:10.1148/radiol.2016150633  PMID:26829523  PMCID:PMC4942992
    • Allred, J. J., Flores-Hernandez, C., Hoenecke, H. R., D'Lima, D. D. Posterior augmented glenoid implants require less bone removal and generate lower stresses: a finite element analysis Journal of Shoulder and Elbow Surgery  2016 25:823-830  DOI:10.1016/j.jse.2015.10.003  PMID:26775743
    • Kwok, J., Onuma, H., Olmer, M., Lotz, M. K., Grogan, S. P., D'Lima, D. D. Histopathological analyses of murine menisci: implications for joint aging and osteoarthritis Osteoarthritis and Cartilage  2016 24:709-718  DOI:10.1016/j.joca.2015.11.006  PMID:26585241  PMCID:PMC4799761
    • Baek, J., Sovani, S., Glembotski, N. E., Du, J., Jin, S., Grogan, S. P., D'Lima, D. D. Repair of avascular meniscus tears with electrospun collagen scaffolds seeded with human cells Tissue Engineering Part A  2016 22:436-448  DOI:10.1089/ten.tea.2015.0284  PMID:26842062  PMCID:PMC4800276
    • Kador, K. E., Grogan, S. P., Dorthe, E. W., Venugopalan, P., Malek, M. F., Goldberg, J. L., D'Lima, D. D. Control of retinal ganglion cell positioning and neurite growth: combining 3D printing with radial electrospun scaffolds Tissue Engineering Part A  2016 22:286-294  DOI:10.1089/ten.tea.2015.0373  PMID:26729061  PMCID:PMC4779292
    • Temple-Wong, M. M., Ren, S., Quach, P., Hansen, B. C., Chen, A. C., Hasegawa, A., D'Lima, D. D., Koziol, J., Masuda, K., Lotz, M. K., Sah, R. L. Hyaluronan concentration and size distribution in human knee synovial fluid: variations with age and cartilage degeneration Arthritis Research & Therapy  2016 18  DOI:10.1186/s13075-016-0922-4  PMID:26792492  PMCID:PMC4721052
    • Patil, S., Bunn, A., Bugbee, W. D., Colwell, C. W., D'Lima, D. D. Patient-specific implants with custom cutting blocks better approximate natural knee kinematics than standard TKA without custom cutting blocks Knee  2015 22:624-629  DOI:10.1016/j.knee.2015.08.002
    • Netter, J., Hermida, J. C., D'Alessio, J., Kester, M., D'Lima, D. D. Effect of polyethylene crosslinking and bearing design on wear of unicompartmental arthroplasty Journal of Arthroplasty  2015 30:1430-1433  DOI:10.1016/j.arth.2015.03.026  PMID:25865811
    • Kersten, A. D., Flores-Hernandez, C., Hoenecke, H. R., D'Lima, D. D. Posterior augmented glenoid designs preserve more bone in biconcave glenoids Journal of Shoulder and Elbow Surgery  2015 24:1135-1141  DOI:10.1016/j.jse.2014.12.007  PMID:25618465
    • Chang, E. Y., Bae, W. C., Shao, H., Biswas, R., Li, S., Chen, J., Patil, S., Healey, R., D'Lima, D. D., Chung, C. B., Du, J. Ultrashort echo time magnetization transfer (UTE-MT) imaging of cortical bone NMR in Biomedicine  2015 28:873-880  DOI:10.1002/nbm.3316  PMID:25981914  PMCID:PMC4652942
    • Kessler, O., Sommers, M., Augustin, T., Haybaeck, J., D'Lima, D. D., Madey, S. M., Bottlang, M. Higher strains in the inner region of the meniscus indicate a potential source for degeneration Journal of Biomechanics  2015 48:1377-1382  DOI:10.1016/j.jbiomech.2015.02.059  PMID:25801421
    • Mizu-uchi, H., Colwell Jr., C. W., Flores-Hernandez, C., Fregly, B. J., Matsuda, S., D'Lima, D. D. Patient-specific computer model of dynamic squatting after total knee arthroplasty Journal of Arthroplasty  2015 30:870-874  DOI:10.1016/j.arth.2014.12.021  PMID:25662671  PMCID:PMC4426034
    • Baek, J., Chen, X., Sovani, S., Jin, S., Grogan, S. P., D'Lima, D. D. Meniscus tissue engineering using a novel combination of electrospun scaffolds and human meniscus cells embedded within an extracellular matrix hydrogel Journal of Orthopaedic Research  2015 33:572-583  DOI:10.1002/jor.22802  PMID:25640671  PMCID:PMC4386835
    • Kwok, J., Grogan, S., Meckes, B., Arce, F., Lal, R., D'Lima, D. Atomic force microscopy reveals age-dependent changes in nanomechanical properties of the extracellular matrix of native human menisci: implications for joint degeneration and osteoarthritis Nanomedicine-Nanotechnology Biology and Medicine  2014 10:1777-1785  DOI:10.1016/j.nano.2014.06.010  PMID:24972006  PMCID:PMC4374607
    • Bunn, A., Colwell, C. W., D'Lima, D. D. Effect of head diameter on passive and active dynamic hip dislocation Journal of Orthopaedic Research  2014 32:1525-1531  DOI:10.1002/jor.22659  PMID:24961686
    • MacEwan, L. J., Glembotski, N. E., D'Lima, D., Bae, W., Masuda, K., Rashidi, H. H., Mell, L. K., Bydder, M. Proton density water fraction as a biomarker of bone marrow cellularity: validation in ex vivo spine specimens Magnetic Resonance Imaging  2014 32:1097-1101  DOI:10.1016/j.mri.2014.03.005  PMID:25240720
    • Netter, J. D., Hermida, J. C., Chen, P. C., Nevelos, J. E., D'Lima, D. D. Effect of microseparation and third-body particles on dual-mobility crosslinked hip liner wear Journal of Arthroplasty  2014 29:1849-1853  DOI:10.1016/j.arth.2014.04.010  PMID:24891003
    • Bae, W. C., Patil, S., Biswas, R., Li, S. H., Chang, E. Y., Statum, S., D'Lima, D. D., Chung, C. B., Du, J. Magnetic resonance imaging assessed cortical porosity is highly correlated with muCT porosity Bone  2014 66:56-61  DOI:10.1016/j.bone.2014.06.004  PMID:24928498  PMCID:PMC4125420
    • Hoenecke, H. R., Flores-Hernandez, C., D'Lima, D. D. Reverse total shoulder arthroplasty component center of rotation affects muscle function Journal of Shoulder and Elbow Surgery  2014 23:1128-1135  DOI:10.1016/j.jse.2013.11.025  PMID:24613182
    • Novitskaya, E., Zin, C., Chang, N., Cory, E., Chen, P., D'Lima, D., Sah, R. L., McKittrick, J. Creep of trabecular bone from the human proximal tibia Materials Science & Engineering C-Materials for Biological Applications  2014 40:219-227  DOI:10.1016/j.msec2014.03.057  PMID:24857486  PMCID:PMC4071770
    • Hermida, J. C., Flores-Hernandez, C., Hoenecke, H. R., D'Lima, D. D. Augmented wedge-shaped glenoid component for the correction of glenoid retroversion: a finite element analysis Journal of Shoulder and Elbow Surgery  2014 23:347-354  DOI:10.1016/j.jse.2013.06.008  PMID:24007648
    • Walter, J. P., Kinney, A. L., Banks, S. A., D'Lima, D. D., Besier, T. F., Lloyd, D. G., Fregly, B. J. Muscle synergies may improve optimization prediction of knee contact forces during walking Journal of Biomechanical Engineering-Transactions of the Asme  2014 136:021031  DOI:10.1115/1.4026428  PMID:24402438
    • Olee, T., Grogan, S. P., Lotz, M. K., Colwell, C. W., D'Lima, D. D., Snyder, E. Y. Repair of cartilage defects in arthritic tissue with differentiated human embryonic stem cells Tissue Engineering Part A  2014 20:683-692  DOI:10.1089/ten.tea.2012.0751  PMID:24028447  PMCID:PMC3926163
    • Patil, S., Steklov, N., Song, L., Bae, W. C., D'Lima, D. D. Comparative biomechanical analysis of human and caprine knee articular cartilage Knee  2014 21:119-125  DOI:10.1016/j.knee.2013.03.009  PMID:23583005
    • Grogan, S. P., Chen, X., Sovani, S., Taniguchi, N., Colwell Jr., C. W., Lotz, M. K., D'Lima, D. D. Influence of cartilage extracellular matrix molecules on cell phenotype and neocartilage formation Tissue Engineering Part A  2014 20:264-274  DOI:10.1089/ten.tea.2012.0618  PMID:23962090  PMCID:PMC3875188
    • Gerus, P., Sartori, M., Besier, T. F., Fregly, B. J., Delp, S. L., Banks, S. A., Pandy, M. G., D'Lima, D. D., Lloyd, D. G. Subject-specific knee joint geometry improves predictions of medial tibiofemoral contact forces Journal of Biomechanics  2013 46:2778-2786  DOI:10.1016/j.jbiomech.2013.09.005  PMID:24074941  PMCID:PMC3888900
    • Du, J., Hermida, J. C., Diaz, E., Corbeil, J., Znamirowski, R., D'Lima, D. D., Bydder, G. M. Assessment of cortical bone with clinical and ultrashort echo time sequences Magnetic Resonance in Medicine  2013 70:697-704  DOI:10.1002/mrm.24497  PMID:23001864
    • Grogan, S. P., Chung, P. H., Soman, P., Chen, P., Lotz, M. K., Chen, S. C., D'Lima, D. D. Digital micromirror device projection printing system for meniscus tissue engineering Acta Biomaterialia  2013 9:7218-7226  DOI:10.1016/j.actbio.2013.03.020  PMID:23523536  PMCID:PMC3685281
    • Meyer, A. J., D'Lima, D. D., Besier, T. F., Lloyd, D. G., Colwell, C. W., Fregly, B. J. Are external knee load and EMG measures accurate indicators of internal knee contact forces during gait? Journal of Orthopaedic Research  2013 31:921-929  DOI:10.1002/jor.22304  PMID:23280647  PMCID:PMC3628973
    • Patil, S., Steklov, N., Bugbee, W. D., Goldberg, T., Colwell, C. W., D'Lima, D. D. Anti-gravity treadmills are effective in reducing knee forces Journal of Orthopaedic Research  2013 31:672-679  DOI:10.1002/jor.22272  PMID:23239580
    • Pegg, E. C., Walter, J., Mellon, S. J., Pandit, H. G., Murray, D. W., D'Lima, D. D., Fregly, B. J., Gill, H. S. Evaluation of factors affecting tibial bone strain after unicompartmental knee replacement Journal of Orthopaedic Research  2013 31:821-828  DOI:10.1002/jor.22283  PMID:23192787  PMCID:PMC3602347
    • Kinney, A. L., Besier, T. F., Silder, A., Delp, S. L., D'Lima, D. D., Fregly, B. J. Changes in in vivo knee contact forces through gait modification Journal of Orthopaedic Research  2013 31:434-440  DOI:10.1002/jor.22240  PMID:23027590  PMCID:PMC3553232
    • Levy, Y. D., Hasegawa, A., Patil, S., Koziol, J. A., Lotz, M. K., D'Lima, D. D. Histopathological changes in the human posterior cruciate ligament during aging and osteoarthritis: Correlations with anterior cruciate ligament and cartilage changes Annals of the Rheumatic Diseases  2013 72:271-277  DOI:10.1136/annrheumdis-2012-201730  PMID:22872023  PMCID:PMC3538921
    • Kinney, A. L., Besier, T. F., D'Lima, D. D., Fregly, B. J. Update on grand challenge competition to predict in vivo knee loads Journal of Biomechanical Engineering-Transactions of the Asme  2013 135:021012  DOI:10.1115/1.4023255  PMID:23445057  PMCID:PMC3597120
    • Grogan, S. P., Duffy, S. F., Pauli, C., Koziol, J. A., Su, A. I., D'Lima, D. D., Lotz, M. K. Zone-specific gene expression patterns in articular cartilage Arthritis and Rheumatism  2013 65:418-428  DOI:10.1002/art.37760  PMID:23124445  PMCID:PMC3558601
    • Bugbee, W. D., Mizu-Uchi, H., Patil, S., D'Lima, D. Accuracy of implant placement utilizing customized patient instrumentation in total knee arthroplasty Advances in Orthopedics  2013 2013:891210  DOI:10.1155/2013/891210  PMID:24151556  PMCID:PMC3787656
    • Patil, S., Steklov, N., Colwell, C. W., Kester, M., D 'Lima, D. D. Effect of tibial tray malalignment on micromotion and subsidence: a preliminary report Open Bone Journal  2013 5:1-8  DOI:10.2174/1876525401305010001
    • D'Lima, D. D., Fregly, B. J., Colwell, C. W. Implantable sensor technology: measuring bone and joint biomechanics of daily life in vivo Arthritis Research & Therapy  2013 15:203  DOI:10.1186/ar4138  PMID:23369655  PMCID:PMC3672791
    • D'Lima, D. D. Inflammatory events in cartilage in early stages of femoroacetabular impingement: Commentary on an article by Shingo Hashimoto, MD, PhD, et al.: "Molecular characterization of articular cartilage from young adults with femoroacetabular impingement" Journal of Bone and Joint Surgery  2013 95:e121-e122  DOI:10.2106/jbjs.m.00722  PMID:23965714  PMCID:PMC3748994
    • Hoenecke, H. R., Tibor, L. M., Elias, D. W., Flores-Hernandez, C., Steinvurzel, J. N., D'Lima, D. D. A quantitative three-dimensional templating method for shoulder arthroplasty: biomechanical validation in cadavers Journal of Shoulder and Elbow Surgery  2012 21:1377-1383  DOI:10.1016/j.jse.2011.10.011  PMID:22137376
    • Srivastava, A., Lee, G. Y., Steklov, N., Colwell, C. W., Ezzet, K. A., D'Lima, D. D. Effect of tibial component varus on wear in total knee arthroplasty Knee  2012 19:560-563  DOI:10.1016/j.knee.2011.11.003  PMID:22206820
    • Mizu-uchi, H., Colwell, C. W., Fukagawa, S., Matsuda, S., Iwamoto, Y., D'Lima, D. D. The importance of bony impingement in restricting flexion after total knee arthroplasty computer simulation model with clinical correlation Journal of Arthroplasty  2012 27:1710-1716  DOI:10.1016/j.arth.2012.03.041  PMID:22595182
    • Grogan, S. P., Sovani, S., Pauli, C., Chen, J. F., Hartmann, A., Colwell, C. W., Lotz, M. K., D'Lima, D. D. Effects of perfusion and dynamic loading on human neocartilage formation in alginate hydrogels Tissue Engineering Part A  2012 18:1784-1792  DOI:10.1089/ten.tea.2011.0506  PMID:22536910  PMCID:PMC3432904
    • Hoenecke, H. R., Tibor, L. M., D'Lima, D. D. Glenoid morphology rather than version predicts humeral subluxation: a different perspective on the glenoid in total shoulder arthroplasty Journal of Shoulder and Elbow Surgery  2012 21:1136-1141  DOI:10.1016/j.jse.2011.08.044  PMID:22079801
    • Cui, X. F., Hasegawa, A., Lotz, M., D'Lima, D. Structured three-dimensional co-culture of mesenchymal stem cells with meniscus cells promotes meniscal phenotype without hypertrophy Biotechnology and Bioengineering  2012 109:2369-2380  DOI:10.1002/bit.24495  PMID:22422555  PMCID:PMC3391334
    • Cui, X. F., Breitenkamp, K., Lotz, M., D'Lima, D. Synergistic action of fibroblast growth factor-2 and transforming growth factor-beta1 enhances bioprinted human neocartilage formation Biotechnology and Bioengineering  2012 109:2357-2368  DOI:10.1002/bit.24488  PMID:22508498  PMCID:PMC3402696
    • Pauli, C., Bae, W. C., Lee, M., Lotz, M., Bydder, G. M., D'Lima, D. L., Chung, C. B., Du, J. Ultrashort-echo time MR imaging of the patella with bicomponent analysis: correlation with histopathologic and polarized light microscopic findings Radiology  2012 264:484-493  DOI:10.1148/radiol.12111883  PMID:22653187  PMCID:PMC3401353
    • Grogan, S. P., Pauli, C., Chen, P., Du, J., Chung, C. B., Kong, S. D., Colwell, C. W., Lotz, M. K., Jin, S. G., D'Lima, D. D. In situ tissue engineering using magnetically guided three-dimensional cell patterning Tissue Engineering Part C-Methods  2012 18:496-506  DOI:10.1089/ten.tec.2011.0525  PMID:22224660  PMCID:PMC3381294
    • Macias, B. R., D'Lima, D. D., Cutuk, A., Patil, S., Steklov, N., Neuschwander, T. B., Meuche, S., Colwell, C. W., Hargens, A. R. Leg intramuscular pressures and in vivo knee forces during lower body positive and negative pressure treadmill exercise Journal of Applied Physiology  2012 113:31-38  DOI:10.1152/japplphysiol.01434.2011  PMID:22539171
    • Pauli, C., Whiteside, R., Heras, F. L., Nesic, D., Koziol, J., Grogan, S. P., Matyas, J., Pritzker, K. P. H., D'Lima, D. D., Lotz, M. K. Comparison of cartilage histopathology assessment systems on human knee joints at all stages of osteoarthritis development Osteoarthritis and Cartilage  2012 20:476-485  DOI:10.1016/j.joca.2011.12.018  PMID:22353747  PMCID:PMC3348372
    • Cui, X. F., Breitenkamp, K., Finn, M. G., Lotz, M., D'Lima, D. D. Direct human cartilage repair using three-dimensional bioprinting technology Tissue Engineering Part A  2012 18:1304-1312  DOI:10.1089/ten.tea.2011.0543  PMID:22394017  PMCID:PMC3360507
    • Ledet, E. H., D'Lima, D., Westerhoff, P., Szivek, J. A., Wachs, R. A., Bergmann, G. Implantable sensor technology: from research to clinical practice Journal of the American Academy of Orthopaedic Surgeons  2012 20:383-392  DOI:10.5435/jaaos-20-06-383  PMID:22661568
    • Nazor, K. L., Altun, G., Lynch, C., Tran, H., Harness, J. V., Slavin, I., Garitaonandia, I., Muller, F. J., Wang, Y. C., Boscolo, F. S., Fakunle, E., Dumevska, B., et al. Recurrent variations in DNA methylation in human pluripotent stem cells and their differentiated derivatives Cell Stem Cell  2012 10:620-634  DOI:10.1016/j.stem.2012.02.013  PMID:22560082  PMCID:PMC3348513
    • Fregly, B. J., Besier, T. F., Lloyd, D. G., Delp, S. L., Banks, S. A., Pandy, M. G., D'Lima, D. D. Grand challenge competition to predict in vivo knee loads Journal of Orthopaedic Research  2012 30:503-513  DOI:10.1002/jor.22023  PMID:22161745  PMCID:PMC4067494
    • Carames, B., Taniguchi, N., Seino, D., Blanco, F. J., D'Lima, D., Lotz, M. Mechanical injury suppresses autophagy regulators and pharmacologic activation of autophagy results in chondroprotection Arthritis and Rheumatism  2012 64:1182-1192  DOI:10.1002/art.33444  PMID:22034068  PMCID:PMC3288456
    • Bae, W. C., Chen, P. C., Chung, C. B., Masuda, K., D'Lima, D., Du, J. Quantitative ultrashort echo time (UTE) MRI of human cortical bone: correlation with porosity and biomechanical properties Journal of Bone and Mineral Research  2012 27:848-857  DOI:10.1002/jbmr.1535  PMID:22190232  PMCID:PMC3463505
    • Hasegawa, A., Otsuki, S., Pauli, C., Miyaki, S., Patil, S., Steklov, N., Kinoshita, M., Koziol, J., D'Lima, D. D., Lotz, M. K. Anterior cruciate ligament changes in the human knee joint in aging and osteoarthritis Arthritis and Rheumatism  2012 64:696-704  DOI:10.1002/art.33417  PMID:22006159  PMCID:PMC3266452
    • Bunn, A., Colwell, C. W., D'Lima, D. D. Bony impingement limits design-related increases in hip range of motion Clinical Orthopaedics and Related Research  2012 470:418-427  DOI:10.1007/s11999-011-2096-3  PMID:21918798  PMCID:PMC3254736
    • Gokhin, D. S., Kim, N. E., Lewis, S. A., Hoenecke, H. R., D'Lima, D. D., Fowler, V. M. Thin-filament length correlates with fiber type in human skeletal muscle American Journal of Physiology-Cell Physiology  2012 302:C555-C565  DOI:10.1152/ajpcell.00299.2011  PMID:22075691  PMCID:PMC3287155
    • D'Lima, D. D., Fregly, B. J., Patil, S., Steklov, N., Colwell, C. W. Knee joint forces: prediction, measurement, and significance Proceedings of the Institution of Mechanical Engineers Part H-Journal of Engineering in Medicine  2012 226:95-102  DOI:10.1177/0954411911433372  PMID:22468461  PMCID:PMC3324308
    • Cui, X., Boland, T., D'Lima, D. D., Lotz, M. K. Thermal inkjet printing in tissue engineering and regenerative medicine Recent Patents on Drug Delivery & Formulation  2012 6:149-155  PMID:22436025  PMCID:PMC3565591
    • Ezzet, K. A., Hermida, J. C., Steklov, N., D'Lima, D. D. Wear of polyethylene against oxidized zirconium femoral components effect of aggressive kinematic conditions and malalignment in total knee arthroplasty Journal of Arthroplasty  2012 27:116-121  DOI:10.1016/j.arth.2011.06.002  PMID:21908170
    • Johnson, L. L., Verioti, C., Gelber, J., Spector, M., D'Lima, D., Pittsley, A. The pathology of the end-stage osteoarthritic lesion of the knee: potential role in cartilage repair Knee  2011 18:402-406  DOI:10.1016/j.knee.2010.07.012  PMID:20934341
    • D'Lima, D. D., Patil, S., Steklov, N., Colwell, C. W. The 2011 ABJS Nicolas Andry Award: 'Lab'-in-a-knee: in vivo knee forces, kinematics, and contact analysis Clinical Orthopaedics and Related Research  2011 469:2953-2970  DOI:10.1007/s11999-011-1916-9  PMID:21598121  PMCID:PMC3171531
    • Mizu-uchi, H., Colwell, C. W., Matsuda, S., Flores-Hernandez, C., Iwamoto, Y., D'Lima, D. D. Effect of total knee arthroplasty implant position on flexion angle before implant-bone impingement Journal of Arthroplasty  2011 26:721-727  DOI:10.1016/j.arth.2010.08.002  PMID:20870382
    • Li, L. M., Patil, S., Steklov, N., Bae, W., Temple-Wong, M., D'Lima, D. D., Sah, R. L., Fregly, B. J. Computational wear simulation of patellofemoral articular cartilage during in vitro testing Journal of Biomechanics  2011 44:1507-1513  DOI:10.1016/j.jbiomech.2011.03.012  PMID:21453922  PMCID:PMC3119794
    • Wong, J., Steklov, N., Patil, S., Flores-Hernandez, C., Kester, M., Colwell, C. W., D'Lima, D. D. Predicting the effect of tray malalignment on risk for bone damage and implant subsidence after total knee arthroplasty Journal of Orthopaedic Research  2011 29:347-353  DOI:10.1002/jor.21221  PMID:20882595
    • Chen, P. C., Colwell, C. W., D'Lima, D. D. A nonlinear viscoelastic finite element model of polyethylene Molecular & Cellular Biomechanics  2011 8:135-148  PMID:21608414
    • Gelber, J., Hermida, J. C., Patil, S., Colwell, C. W., D 'Lima, D. D. Effect of biomimetic nanocrystalline apatite surface on bone ingrowth Journal of Biomimetics, Biomaterials, and Tissue Engineering  2011 12:41-50
    • D'Lima, D. D., Chen, P. C., Kessler, O., Hoenecke, H. R., Colwell, C. W., Jr. Effect of meniscus replacement fixation technique on restoration of knee contact mechanics and stability Molecular & Cellular Biomechanics  2011 8:123-134  PMID:21608413
    • Colwell, C. W., Jr., Chen, P. C., D'Lima, D. Extensor malalignment arising from femoral component malrotation in knee arthroplasty: effect of rotating-bearing Clinical Biomechanics  2011 26:52-57  DOI:10.1016/j.clinbiomech.2010.08.009  PMID:20869142
    • Pauli, C., Grogan, S. P., Patil, S., Otsuki, S., Hasegawa, A., Koziol, J., Lotz, M. K., D'Lima, D. D. Macroscopic and histopathologic analysis of human knee menisci in aging and osteoarthritis Osteoarthritis and Cartilage  2011 19:1132-1141  DOI:10.1016/j.joca.2011.05.008  PMID:21683797  PMCID:PMC3217905
    • Haudenschild, D. R., Chen, J. F., Pang, N. N., Steklov, N., Grogan, S. P., Lotz, M. K., D'Lima, D. D. Vimentin contributes to changes in chondrocyte stiffness in osteoarthritis Journal of Orthopaedic Research  2011 29:20-25  DOI:10.1002/jor.21198  PMID:20602472  PMCID:PMC2976780
    • Erhart, J. C., Dyrby, C. O., D'Lima, D. D., Colwell, C. W., Andriacchi, T. P. Changes in in vivo knee loading with a variable-stiffness intervention shoe correlate with changes in the knee adduction moment Journal of Orthopaedic Research  2010 28:1548-1553  DOI:10.1002/jor.21183  PMID:20973058  PMCID:PMC2965044
    • Walter, J. P., D'Lima, D. D., Colwell, C. W., Fregly, B. J. Decreased knee adduction moment does not guarantee decreased medial contact force during gait Journal of Orthopaedic Research  2010 28:1348-1354  DOI:10.1002/jor.21142  PMID:20839320  PMCID:PMC2984615
    • McKinley, T. O., Borrelli, J., D'Lima, D. D., Furman, B. D., Glannoudis, P. V. Basic science of intra-articular fractures and posttraumatic osteoarthritis Journal of Orthopaedic Trauma  2010 24:567-570  DOI:10.1097/BOT.0b013e3181ed298d  PMID:20736796  PMCID:PMC3662545
    • Lotz, M. K., Otsuki, S., Grogan, S. P., Sah, R., Terkeltaub, R., D'Lima, D. Cartilage cell clusters Arthritis and Rheumatism  2010 62:2206-2218  DOI:10.1002/art.27528  PMID:20506158  PMCID:PMC2921934
    • Hoenecke, H. R., Hermida, J. C., Flores-Hernandez, C., D'Lima, D. D. Accuracy of CT-based measurements of glenoid version for total shoulder arthroplasty Journal of Shoulder and Elbow Surgery  2010 19:166-171  DOI:10.1016/j.jse.2009.08.009  PMID:19959378
    • Bae, W. C., Dwek, J. R., Znamirowski, R., Statum, S. M., Hermida, J. C., D'Lima, D. D., Sah, R. L., Du, J., Chung, C. B. Ultrashort echo time MR imaging of osteochondral junction of the knee at 3 T: identification of anatomic structures contributing to signal intensity Radiology  2010 254:837-845  DOI:10.1148/radiol.09081743  PMID:20177096  PMCID:PMC2826697
    • Hermida, J. C., Bergula, A., Dimaano, F., Hawkins, M., Colwell, C. W., D'Lima, D. D. An in vivo evaluation of bone response to three implant surfaces using a rabbit intramedullary rod model Journal of Orthopaedic Surgery and Research  2010 5:57  DOI:10.1186/1749-799x-5-57  PMID:20712889  PMCID:PMC2933710
    • Grogan, S. P., D'Lima, D. D. Joint aging and chondrocyte cell death International Journal of Clinical Rheumatology  2010 5:199-214  DOI:10.2217/ijr.10.3  PMID:20671988  PMCID:PMC2909784
    • Blake, J. A., Steklov, N., Patil, S., Colwell, C. W., D 'Lima, D. D. Knee loads during golf: implications after TKA Lower Extremity Review  2010 2
    • Haudenschild, D. R., Chen, J. F., Pang, N. N., Lotz, M. K., D'Lima, D. D. Rho kinase-dependent activation of SOX9 in chondrocytes Arthritis and Rheumatism  2010 62:191-200  DOI:10.1002/art.25051  PMID:20039424  PMCID:PMC2935318
    • Mai, K. T., Verioti, C., D'Lima, D., Colwell, C. W., Jr., Ezzet, K. A., Jr. Surface roughness of femoral head prostheses after dislocation American Journal of Orthopedics  2010 39:495-500  PMID:21290011
    • Steklov, N., Slamin, J., Srivastav, S., D'Lima, D. Unicompartmental knee resurfacing: enlarged tibio-femoral contact area and reduced contact stress using novel patient-derived geometries Open Biomedical Engineering Journal  2010 4:85-92  DOI:10.2174/1874120701004010085  PMID:20461223  PMCID:PMC2866246
    • Fregly, B. J., D'Lima, D. D., Colwell, C. W. Effective gait patterns for offloading the medial compartment of the knee Journal of Orthopaedic Research  2009 27:1016-1021  DOI:10.1002/jor.20843  PMID:19148939  PMCID:PMC2719763
    • Steklov, N., Srivastava, A., Sung, K. L., Chen, P. C., Lotz, M. K., D'Lima, D. D. Aging-related differences in chondrocyte viscoelastic properties Molecular & Cellular Biomechanics  2009 6:113-119  PMID:19496259
    • Haudenschild, D. R., Chen, J., Steklov, N., Lotz, M. K., D'Lima, D. D. Characterization of the chondrocyte actin cytoskeleton in living three-dimensional culture: response to anabolic and catabolic stimuli Molecular & Cellular Biomechanics  2009 6:135-144  PMID:19670824  PMCID:PMC2785729
    • Petrella, A. J., Stowe, J. Q., D'Lima, D. D., Rullkoetter, P. J., Laz, P. J. Computer-assisted versus manual alignment in THA: a probabilistic approach to range of motion Clinical Orthopaedics and Related Research  2009 467:50-55  DOI:10.1007/s11999-008-0561-4  PMID:18941857  PMCID:PMC2600980
    • Grogan, S. P., Miyaki, S., Asahara, H., D'Lima, D. D., Lotz, M. K. Mesenchymal progenitor cell markers in human articular cartilage: normal distribution and changes in osteoarthritis Arthritis Research & Therapy  2009 11:R85  DOI:10.1186/ar2719  PMID:19500336  PMCID:PMC2714136
    • D 'Lima, D. D., Chen, P. C., Colwell, C. W. Osteochondral grafting: effect of graft alignment, material properties, and articular geometry Open Orthopaedics Journal  2009 3:61-68  DOI:10.2174/1874325000903010061  PMID:19696917  PMCID:PMC2729389
    • Kessler, O., Patil, S., Colwell, C. W., D'Lima, D. D. The effect of femoral component malrotation on patellar biomechanics Journal of Biomechanics  2008 41:3332-3339  DOI:10.1016/j.jbiomech.2008.09.032  PMID:19019376
    • D'Lima, D. D., Steklov, N., Fregly, B. J., Banks, S. A., Colwell, C. W. In vivo contact stresses during activities of daily living after knee arthroplasty Journal of Orthopaedic Research  2008 26:1549-1555  DOI:10.1002/jor.20670  PMID:18524001
    • Hermida, J. C., Fischler, A., Colwell, C. W., D'Lima, D. D. The effect of oxidative aging on the wear performance of highly crosslinked polyethylene knee inserts under conditions of severe malalignment Journal of Orthopaedic Research  2008 26:1585-1590  DOI:10.1002/jor.20686  PMID:18524011
    • D'Lima, D. D., Steklov, N., Patil, S., Colwell, C. W. The Mark Coventry Award: in vivo knee forces during recreation and exercise after knee arthroplasty Clinical Orthopaedics and Related Research  2008 466:2605-2611  DOI:10.1007/s11999-008-0345-x  PMID:18563502  PMCID:PMC2565055
    • Simpson, D. J., Gray, H., D'Lima, D., Murray, D. W., Gill, H. S. The effect of bearing congruency, thickness and alignment on the stresses in unicompartmental knee replacements Clinical Biomechanics  2008 23:1148-1157  DOI:10.1016/j.clinbiomech.2008.06.001  PMID:18639960
    • Patil, S., Butcher, W., D'Lima, D. D., Steklov, N., Bugbee, W. D., Hoenecke, H. R. Effect of osteochondral graft insertion forces on chondrocyte viability American Journal of Sports Medicine  2008 36:1726-1732  DOI:10.1177/0363546508316765  PMID:18490471
    • Mundermann, A., Dyrby, C. O., D'Lima, D. D., Colwell, C. W., Andriacchi, T. P. In vivo knee loading characteristics during activities of daily living as measured by an instrumented total knee replacement Journal of Orthopaedic Research  2008 26:1167-1172  DOI:10.1002/jor.20655  PMID:18404700
    • Haudenschild, D. R., Nguyen, B., Chen, J., D'Lima, D. D., Lotz, M. K. Rho kinase-dependent CCL20 induced by dynamic compression of human chondrocytes Arthritis and Rheumatism  2008 58:2735-2742  DOI:10.1002/art.23797  PMID:18759278  PMCID:PMC2562294
    • Fregly, B. J., Banks, S. A., D'Lima, D. D., Colwell, C. W. Sensitivity of knee replacement contact calculations to kinematic measurement errors Journal of Orthopaedic Research  2008 26:1173-1179  DOI:10.1002/jor.20548  PMID:18383141
    • Varadarajan, K. M., Moynihan, A. L., D'Lima, D., Colwell, C. W., Li, G. In vivo contact kinematics and contact forces of the knee after total knee arthroplasty during dynamic weight-bearing activities Journal of Biomechanics  2008 41:2159-2168  DOI:10.1016/j.jbiomech.2008.04.021  PMID:18538328  PMCID:PMC3177238
    • Hoenecke, H. R., Hermida, J. C., Dembitsky, N., Patil, S., D'Lima, D. D. Optimizing glenoid component position using three-dimensional computed tomography reconstruction Journal of Shoulder and Elbow Surgery  2008 17:637-641  DOI:10.1016/j.jse.2007.11.021  PMID:18374607
    • Otsuki, S., Brinson, D. C., Creighton, L., Kinoshita, M., Sah, R. L., D'Lima, D., Lotz, M. The effect of glycosaminoglycan loss on chondrocyte viability: a study on porcine cartilage explants Arthritis and Rheumatism  2008 58:1076-1085  DOI:10.1002/art.23381  PMID:18383360
    • Hall, J., Copp, S. N., Adelson, W. S., D'Lima, D. D., Colwell, C. W. Extensor mechanism function in single-radius vs multiradius femoral components for total knee arthroplasty Journal of Arthroplasty  2008 23:216-219  DOI:10.1016/j.arth.2007.04.001  PMID:18280415
    • Van den Berghe, G. R., Nguyen, B., Patil, S., D'Lima, D. D., Mahar, A., Pedowitz, R., Hoenecke, H. R. A biomechanical evaluation of three surgical techniques for subscapularis repair Journal of Shoulder and Elbow Surgery  2008 17:156-161  DOI:10.1016/j.jse.2007.04.016  PMID:17931907
    • Kessler, O., Pati, S., Stefan, W., Mayr, E., Colwell, C. W., D'Lima, D. D. Bony impingement affects range of motion after total hip arthroplasty: a subject-specific approach Journal of Orthopaedic Research  2008 26:443-452  DOI:10.1002/jor.20541  PMID:18050356
    • Haudenschild, D. R., D'Lima, D. D., Lotz, M. K. Dynamic compression of chondrocytes induces a Rho kinase-dependent reorganization of the actin cytoskeleton Biorheology  2008 45:219-228  DOI:10.3233/bir-2008-0499  PMID:18836226
    • Otsuki, S., Taniguchi, N., Grogan, S. P., D'Lima, D., Kinoshita, M., Lotz, M. Expression of novel extracellular sulfatases Sulf-1 and Sulf-2 in normal and osteoarthritic articular cartilage Arthritis Research & Therapy  2008 10:R61  DOI:10.1186/ar2432  PMID:18507859  PMCID:PMC2483452
    • McKellop, H. A., D'Lima, D., Implant Wear Symposium Engn, W. How have wear testing and joint simulator studies helped to discriminate among materials and designs? Journal of the American Academy of Orthopaedic Surgeons  2008 16:S111-S119  DOI:10.5435/00124635-200800001-00022  PMID:18612005
    • D'Lima, D. D., Patil, S., Steklov, N., Colwell, C. W. Dynamic intraoperative ligament balancing for total knee arthroplasty Clinical Orthopaedics and Related Research  2007 208-212  DOI:10.1097/BLO.0b013e318150dc2c  PMID:17960684
    • Tam, H. K., Srivastava, A., Colwell, C. W., D'Lima, D. D. In vitro model of full-thickness cartilage defect healing Journal of Orthopaedic Research  2007 25:1136-1144  DOI:10.1002/jor.20428  PMID:17549725
    • Zhao, D., Banks, S. A., Mitchell, K. H., D'Lima, D. D., Colwell, C. W., Fregly, B. J. Correlation between the knee adduction torque and medial contact force for a variety of gait patterns Journal of Orthopaedic Research  2007 25:789-797  DOI:10.1002/jor.20379  PMID:17343285
    • Zhao, D., Banks, S. A., D'Lima, D. D., Colwell, C. W., Fregly, B. J. In vivo medial and lateral tibial loads during dynamic and high flexion activities Journal of Orthopaedic Research  2007 25:593-602  DOI:10.1002/jor.20362  PMID:17290383
    • Patil, S., D'Lima, D. D., Fait, J. M., Colwell, C. W. Improving tibial component coronal alignment during total knee arthroplasty with use of a tibial planing device Journal of Bone and Joint Surgery-American Volume  2007 89A:381-387  DOI:10.2106/jbjs.f.00204  PMID:17272454
    • D'Lima, D. D., Patil, S., Steklov, N., Chien, S., Colwell, C. W. In vivo knee moments and shear after total knee arthroplasty Journal of Biomechanics  2007 40:S11-S17  DOI:10.1016/j.jbiomech.2007.03.004  PMID:17462659
    • Hardwick, M. E., Pulido, P. A., D'Lima, D. D., Colwell, C. W. e-Knee: The electronic knee prosthesis Orthopaedic Nursing  2006 25:326-329  PMID:17035919
    • Davis, D. K., Goltz, D. H., Fithian, D. C., D'Lima, D. Anatomical posterior cruciate ligament transplantation: a biomechanical analysis American Journal of Sports Medicine  2006 34:1126-1133  DOI:10.1177/0363546506288238  PMID:16735590
    • D'Lima, D., Hermida, J., Hashimoto, S., Colwell, C., Lotz, M. Caspase inhibitors reduce severity of cartilage lesions in experimental osteoarthritis Arthritis and Rheumatism  2006 54:1814-1821  DOI:10.1002/art.21874  PMID:16736522
    • D'Lima, D. D., Patil, S., Steklov, N., Slamin, J. E., Colwell, C. W. Tibial forces measured in vivo after total knee arthroplasty Journal of Arthroplasty  2006 21:255-262  DOI:10.1016/j.arth.2005.07.011  PMID:16520216
    • Kirking, B., Krevolin, J., Townsend, C., Colwell, C. W., D'Lima, D. D. A multiaxial force-sensing implantable tibial prosthesis Journal of Biomechanics  2006 39:1744-1751  DOI:10.1016/j.jbiomech.2005.05.023  PMID:16023656
    • Gordon, A. C., D'Lima, D. D., Colwell, C. W., Jr. Highly cross-linked polyethylene in total hip arthroplasty Journal of the American Academy of Orthopaedic Surgeons  2006 14:511-523  PMID:16959889
    • Hermida, J. C., D'Lima, D. D., Steklov, A., Colwell, C. W. Outcome of an acetabular design with hydroxyapatite coating on a rough substrate Clinical Orthopaedics and Related Research  2005 298-304  DOI:10.1097/01.blo.0000192041.08827.cf
    • D'Lima, D. D., Patil, S., Steklov, N., Slamin, J. E., Colwell, C. W. The Chitranjan Ranawat Award - in vivo knee forces after total knee arthroplasty Clinical Orthopaedics and Related Research  2005 45-49  DOI:10.1097/01.blo.0000186559.62942.8c
    • Lee, G. Y., Srivastava, A., D'Lima, D. D., Pulido, P. A., Colwell, C. W. Hydroxyapatite-coated femoral stem survivorship at 10 years Journal of Arthroplasty  2005 20:57-62  DOI:10.1016/j.arth.2005.04.022  PMID:16214004
    • Browne, C., Hermida, J. C., Bergula, A., Colwell, C. W., D'Lima, D. D. Patellofemoral forces after total knee arthroplasty: Effect of extensor moment arm Knee  2005 12:81-88  DOI:10.1016/j.knee.2004.05.006  PMID:15749440
    • D'Lima, D. D., Townsend, C. P., Arms, S. W., Morris, B. A., Colwell, C. W. An implantable telemetry device to measure intra-articular tibial forces Journal of Biomechanics  2005 38:299-304  DOI:10.1016/j.jbiomech.2004.02.011  PMID:15598457
    • Patil, S., Colwell, C. W., Ezzet, K. A., D'Lima, D. D. Can normal knee kinematics be restored with unicompartmental knee replacement? Journal of Bone and Joint Surgery-American Volume  2005 87A:332-338  DOI:10.2106/jbjs.c.01467  PMID:15687156
    • Shikhman, A. R., Amiel, D., D'Lima, D., Hwang, S. B., Hu, C., Xu, A., Hashimoto, S., Kobayashi, K., Sasho, T., Lotz, M. K. Chondroprotective activity of N-acetylglucosamine in rabbits with experimental osteoarthritis Annals of the Rheumatic Diseases  2005 64:89-94  DOI:10.1136/ard.2003.019406  PMID:15608304  PMCID:PMC1755188
    • Poole, C. E., Patil, S. S., D'Lima, D. D., Colwell, C. W., Jr. Early follow-up for a hybrid total hip arthroplasty using a metal-backed acetabular component designed to reduce "backside" polyethylene wear HSS Journal  2005 1:31-34  DOI:10.1007/s11420-005-0102-6  PMID:18751806  PMCID:PMC2504131
    • Ezzet, K. A., Hermida, J. C., Colwell, C. W., D'Lima, D. D. Oxidized zirconium femoral components reduce polyethylene wear in a knee wear simulator Clinical Orthopaedics and Related Research  2004 120-124  DOI:10.1097/01.blo.000048576.70780.13  PMID:15534531
    • Kuhn, K., D'Lima, D. D., Hashimoto, S., Lotz, M. Cell death in cartilage Osteoarthritis and Cartilage  2004 12:1-16  DOI:10.1016/j.joca.2003.09.015  PMID:14697678
    • D'Lima, D. D., Kuhn, K., Lotz, M. K. Detection of apoptosis in cartilage in situ and in isolated chondrocytes Methods in Molecular Medicine  2004 100:275-290  DOI:10.1385/1-59259-810-2:275  PMID:15280601
    • Hermida, J. C., Bergula, A., Chen, P., Colwell, C. W., D'Lima, D. D. Comparison of the wear rates of twenty-eight and thirty-two-millimeter femoral heads on cross-linked polyethylene acetabular cups in a wear simulator Journal of Bone and Joint Surgery-American Volume  2003 85A:2325-2331  DOI:10.2106/00004623-200312000-00009  PMID:14668501
    • D'Lima, D. D., Hermida, J. C., Chen, P. C., Colwell, C. W. Polyethylene cross-linking by two different methods reduces acetabular liner wear in a hip joint wear simulator Journal of Orthopaedic Research  2003 21:761-766  DOI:10.1016/s0736-0266(02)00240-1  PMID:12919860
    • Allard, P., Cristofolini, L., D'Lima, D. D., Kirtley, C., Leardini, A., Rosenbaum, D., Schmid, O., Siegler, S., Stokes, I., Whittle, M., Witte, H., Wu, G. ISB recommendation on definition of joint coordinate systems for the reporting of human joint motion - Part I: ankle, hip and spine - Reply Journal of Biomechanics  2003 36:303-304  DOI:10.1016/s0021-9290(02)00339-1
    • D'Lima, D. D., Chen, P. C., Kester, M. A., Colwell, C. W. Impact of patellofemoral design on patellofemoral forces and polyethylene stresses Journal of Bone and Joint Surgery-American Volume  2003 85A:85-93  DOI:10.2106/00004623-200300004-00010  PMID:14652397
    • Patil, S., Bergula, A., Chen, P. C., Colwell, C. W., D'Lima, D. D. Polyethylene wear and acetabular component orientation Journal of Bone and Joint Surgery-American Volume  2003 85A:56-63  DOI:10.2106/00004623-200300004-00007  PMID:14652394
    • Botte, M. J., Ezzet, K. A., Pacelli, L. L., Guzman, M. J., Meyer, R. S., Meunier, M. J., D'Lima, D. D., Colwell, C. W. What's new in orthopaedic rehabilitation Journal of Bone and Joint Surgery-American Volume  2002 84A:2312-2320
    • D'Lima, D., Lotz, M., Colwell, C. Impact loading: physiological or pathological? Response Osteoarthritis and Cartilage  2002 10:590-590  DOI:10.1053/joca.2002.0804
    • Wu, G., Siegler, S., Allard, P., Kirtley, C., Leardini, A., Rosenbaum, D., Whittle, M., D'Lima, D. D., Cristofolini, L., Witte, H., Schmid, O., Stokes, H., et al. ISB recommendation on definitions of joint coordinate system of various joints for the reporting of human joint motion. Part I: Ankle, hip, and spine Journal of Biomechanics  2002 35:543-548  DOI:10.1016/s0021-9290(01)00222-6  PMID:11934426
    • D'Lima, D. D., Venn-Watson, E. J., Tripuraneni, P., Colwell, C. W. Indomethacin versus radiation therapy for heterotopic ossification after hip arthroplasty Orthopedics  2001 24:1139-1143  PMID:11770090
    • Botte, M. J., D'Lima, D. D., Meunier, M. J. Whats new in orthopaedic rehabilitation Journal of Bone and Joint Surgery-American Volume  2001 83A:1920-1926
    • D'Lima, D. D., Hashimoto, S., Chen, P. C., Colwell, C. W., Lotz, M. K. Human chondrocyte apoptosis in response to mechanical injury Osteoarthritis and Cartilage  2001 9:712-719  DOI:10.1053/joca.2001.0468  PMID:11795990
    • D'Lima, D. D., Chen, P. C., Colwell, C. W. Polyethylene contact stresses, articular congruity, and knee alignment Clinical Orthopaedics and Related Research  2001 232-238  PMID:11716388
    • D'Lima, D. D., Hermida, J. C., Chen, P. C., Colwell, C. W. Polyethylene wear and variations in knee kinematics Clinical Orthopaedics and Related Research  2001 124-130  PMID:11716373
    • D'Lima, D. D., Poole, C., Chadha, H., Hermida, J. C., Mahar, A., Colwell, C. W. Quadriceps moment arm and quadriceps forces after total knee arthroplasty Clinical Orthopaedics and Related Research  2001 213-220  PMID:11716385
    • Colwell, C. W., D'Lima, D. D., Lotz, M. Association of bone and joint surgeons workshop supplement - Editorial comment Clinical Orthopaedics and Related Research  2001 S2-S5
    • D'Lima, D. D., Colwell, C. W. Clinical objectives for cartilage repair Clinical Orthopaedics and Related Research  2001 S402-S405
    • D'Lima, D. D., Hashimoto, S., Chen, P. C., Colwell, C. W., Lotz, M. K. Impact of mechanical trauma on matrix and cells Clinical Orthopaedics and Related Research  2001 391:S90-S99  PMID:11603728
    • Colwell, C. W., D'Lima, D. A., Hoenecke, H. R., Fronek, J., Pulido, P., Morris, B. A., Chung, C., Resnick, D., Lotz, M. In vivo changes after mechanical injury Clinical Orthopaedics and Related Research  2001 391:S116-S123  PMID:11603696
    • Ezzet, K. A., Hershey, A. L., D'Lima, D. D., Irby, S. E., Kaufman, K. R., Colwell, C. W. Patellar tracking in total knee arthroplasty - inset versus onset design Journal of Arthroplasty  2001 16:838-843  DOI:10.1054/arth.2001.25499  PMID:11607898
    • D'Lima, D. D., Yashar, A. A., Venn-Watson, E. J., Colwell, C. W., Walker, R. H. The Harris-Galante Porous acetabular component at intermediate follow-up Orthopedics  2001 24:747-751  PMID:11518403
    • D'Lima, D. D., Trice, M., Urquhart, A. G., Colwell, C. W. Tibiofemoral conformity and kinematics of rotating-bearing knee prostheses Clinical Orthopaedics and Related Research  2001 235-242
    • D'Lima, D. D., Hashimoto, S., Chen, P. C., Lotz, M. K., Colwell, C. W. Cartilage injury induces chondrocyte apoptosis Journal of Bone and Joint Surgery-American Volume  2001 83A:19-21  DOI:10.2106/00004623-200100021-00004  PMID:11685837
    • Morris, B. A., D'Lima, D. D., Slamin, J., Kovacevic, N., Arms, S. W., Townsend, C. P., Colwell, C. W. E-knee: Evolution of the electronic knee prosthesis - telemetry technology development Journal of Bone and Joint Surgery-American Volume  2001 83A:62-66  DOI:10.2106/00004623-200100021-00013  PMID:11685847
    • D'Lima, D. D., Hashimoto, S., Chen, P. C., Lotz, M. K., Colwell, C. W. In vitro and in vivo models of cartilage injury Journal of Bone and Joint Surgery-American Volume  2001 83A:22-24
    • D'Lima, D. D., Chen, P. C., Colwell, C. W. Optimizing acetabular component position to minimize impingement and reduce contact stress Journal of Bone and Joint Surgery-American Volume  2001 83A:87-91  DOI:10.2106/00004623-200100022-00005  PMID:11712840
    • D'Lima, D. D., Hashimoto, S., Chen, P. C., Lotz, M. K., Colwell, C. W. Prevention of chondrocyte apoptosis Journal of Bone and Joint Surgery-American Volume  2001 83A:25-26  DOI:10.2106/00004623-200100021-00006  PMID:11685840
    • D 'Lima, D. D., Colwell, C. W. Rotating versus fixed bearings: what should we use in the young patient? Current Opinion in Orthopaedics  2001 12:26-32
    • D'Lima, D. D., Trice, M., Urquhart, A. G., Colwell, C. W. Comparison between the kinematics of fixed and rotating bearing knee prostheses Clinical Orthopaedics and Related Research  2000 151-157  PMID:11064985
    • D'Lima, D. D., Urquhart, A. G., Buehler, K. O., Walker, R. H., Colwell, C. W. Range of motion of the hip - Reply Journal of Bone and Joint Surgery-American Volume  2000 82A:1672-1672
    • Buehler, K. O., Venn-Watson, E., D'Lima, D. D., Colwell, C. W. The press-fit condylar total knee system - 8-to 10-year results with a posterior cruciate-retaining design Journal of Arthroplasty  2000 15:698-701  DOI:10.1054/arth.2000.8189  PMID:11021444
    • Kanungo, R., d'Lima, D., Rajalakshmi, B., Natarajan, M. K., Badrinath, S. Throat carriage of pneumococci in healthy school children in the Union Territory of Pondicherry Indian Journal of Medical Research  2000 112:100-103  PMID:11094855
    • D'Lima, D. D., Urquhart, A. G., Buehler, K. O., Walker, R. H., Colwell, C. W. The effect of the orientation of the acetabular and femoral components on the range of motion of the hip at different head-neck ratios Journal of Bone and Joint Surgery-American Volume  2000 82A:315-321  DOI:10.2106/00004623-200003000-00003  PMID:10724224
    • D'Lima, D. D., Walker, R. H., Colwell, C. W. Omnifit-HA stem in total hip arthroplasty - A 2-to 5-year followup Clinical Orthopaedics and Related Research  1999 163-169
    • Buehler, K. O., D'Lima, D. D., Petersilge, W. J., Colwell, C. W., Walker, R. H. Late deep venous thrombosis and delayed weightbearing after total hip arthroplasty Clinical Orthopaedics and Related Research  1999 123-130  PMID:10212605
    • Beuhler, K. O., D 'Lima, D. D., Colwell, C. W., Otis, S. M., Walker, R. H. Venous thromboembolic disease after hybrid hip arthroplasty with negative duplex screening Clinical Orthopaedics and Related Research  1999 168-177
    • Trice, M. E., Walker, R. H., D'Lima, D. D., Morris, B. A., Colwell, C. W. Blood loss and transfusion rate in noncemented and cemented/hybrid total hip arthroplasty. Is there a difference? A comparison of 25 matched pairs Orthopedics  1999 22:S141-S144  PMID:9927115
    • D'Lima, D. D., Lemperle, S. M., Chen, P. C., Holmes, R. E., Colwell, C. W. Bone response to implant surface morphology Journal of Arthroplasty  1998 13:928-934  DOI:10.1016/s0883-5403(98)90201-7  PMID:9880187
    • Urquhart, A. G., D'Lima, D. D., Venn-Watson, E., Colwell, C. W., Walker, R. H. Polyethylene wear after total hip arthroplasty: The effect of a modular femoral head with an extended flange-reinforced neck Journal of Bone and Joint Surgery-American Volume  1998 80A:1641-1647
    • Chen, P. C., Pinto, J. G., Mead, E. H., D'Lima, D. D., Colwell, C. M. Fatigue model to characterize cement-metal interface in dynamic shear Clinical Orthopaedics and Related Research  1998 229-236
    • D'Lima, D. D., Oishi, C. S., Petersilge, W. J., Colwell, C. W., Walker, R. H. 100 cemented versus 100 noncemented stems with comparison of 25 matched pairs Clinical Orthopaedics and Related Research  1998 140-148  PMID:9553546
    • Oishi, C. S., Dlima, D. D., Morris, B. A., Hardwick, M. E., Berkowitz, S. D., Colwell, C. W. Hemodilution with other blood reinfusion techniques in total hip arthroplasty Clinical Orthopaedics and Related Research  1997 132-139  PMID:9186211
    • Petersilge, W. J., Dlima, D. D., Walker, R. H., Colwell, C. W. Prospective study of 100 consecutive Harris-Galante porous total hip arthroplasties - 4- to 8-year follow-up study Journal of Arthroplasty  1997 12:185-193  DOI:10.1016/s0883-5403(97)90065-6  PMID:9139101
    • D 'Lima, D. D., Colwell, C. W. Low molecular weight heparin in the prevention of thromboembolic disease in patients having THA Seminars in Arthroplasty  1997 8:199-205
    • Mathai, E., Singhal, A., Verghese, S., Dlima, D., Mathai, D., Ganesh, A., Thomas, K., Moses, P. Evaluation of an ELISA for the diagnosis of brucellosis Indian Journal of Medical Research  1996 103:323-324  PMID:8707374
    • Dlima, D. D., Colwell, C. W., Morris, B. A., Hardwick, M. E., Kozin, F. The effect of preoperative exercise on total knee replacement outcomes Clinical Orthopaedics and Related Research  1996 174-182  PMID:8620638
    • D'Lima, D. D., Copp, S. N., Colwell, C. W., Jr. Isolated lateral ring meniscus. Case report American Journal of Knee Surgery  1995 8:117-118  PMID:7552608
  • chapter

    • Hermida, J., D'Lima, D. D., Steklov, N., Colwell, C. W. Clinical outcome of current generation hydroxyapatite coated acetabular design Bioceramics 17. 1033-1036. 2005  DOI:10.4028/www.scientific.net/KEM.284-286.1033
    • Hermida, J., Yang, X., Li, P., Patil, S., Colwell, C. W., D'Lima, D. Increased bone ingrowth on a biomimetic nanocrystalline apatite surface Bioceramics 17. 175-178. 2005  DOI:10.4028/www.scientific.net/KEM.284-286.175
    • Hermida, J. C., Patil, S., Dimaano, F., Hawkins, M., Colwell, C. W., D'Lima, D. D. Solution deposition of hydroxyapatite on a highly porous titanium surface enhances osseointegration Bioceramics 17. 215-218. 2005  DOI:10.4028/www.scientific.net/KEM.284-286.215
  • thesis

    • In vivo tibial force measurement after total knee arthroplasty 2007
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Background

education and training

  • University of Bombay 1982
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Contact

full name

  • Darryl David D'Lima

geographic location

  • Scripps California 
  • Scripps Health 

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