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Conti, Bruno
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Conti, Bruno

Faculty Member
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Positions

  • 2017 - Professor (Joint Appointment), Neuroscience , Scripps Research
  • 2017 - Professor, Molecular Medicine , Scripps Research
  • 2000 - Faculty Member, Skaggs Graduate School of Chemical and Biological Sciences , Scripps Research
  • 2013 - 2017 Professor, Chemical Physiology , Scripps Research
  • 2013 - 2017 Professor (Joint Appointment), Molecular and Cellular Neuroscience (MCN) , Scripps Research
  • - 2012 Professor, Molecular and Integrative Neurosciences (MIND) , Scripps Research
Dr. Bruno Conti studies the interaction between the nervous system and the immune system, including the central modulation of immune function and the role of cytokines in the central nervous system; and also investigates the role of core body temperature in regulating energy balance, aging and age-related diseases.

Research Areas research areas

  • Diabetes (UMLS)

Contact

  • bconti@scripps.edu

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  • Bruno Conti, Ph.D.
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Publications

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    • Guijas, C., Montenegro-Burke, J. R., Cintron-Colon, R., Domingo-Almenara, X., Sanchez-Alavez, M., Aguirre, C. A., Shankar, K., Majumder, E. L. W., Billings, E., Conti, B., Siuzdak, G. Metabolic adaptation to calorie restriction Science Signaling  2020 13  DOI:10.1126/scisignal.abb2490  PMID:32900879
    • Aguirre, C. A., Morale, M. C., Peng, Q., Sanchez-Alavez, M., Cintron-Colon, R., Feng, K. G., Fazelpour, S., Maher, P., Conti, B. Two single nucleotide polymorphisms in IL13 and IL13RA1 from individuals with idiopathic Parkinson's disease increase cellular susceptibility to oxidative stress Brain Behavior and Immunity  2020 88:920-924  DOI:10.1016/j.bbi.2020.04.007  PMID:32276028
    • Cintron-Colon, R., Johnson, C. W., Montenegro-Burke, J. R., Guijas, C., Faulhaber, L., Sanchez-Alavez, M., Aguirre, C. A., Shankar, K., Singh, M., Galmozzi, A., Siuzdak, G., Saez, E., et al. Activation of kappa opioid receptor regulates the hypothermic response to calorie restriction and limits body weight loss Current Biology  2019 29:4291-4299  DOI:10.1016/j.cub.2019.10.027  PMID:31786059  PMCID:PMC6917995
    • Galmozzi, A., Kok, B. P., Kim, A. S., Montenegro-Burke, J. R., Lee, J. Y., Spreafico, R., Mosure, S., Albert, V., Cintron-Colon, R., Godio, C., Webb, W. R., Conti, B., et al. PGRMC2 is an intracellular haem chaperone critical for adipocyte function Nature  2019 576:138-142  DOI:10.1038/s41586-019-1774-2  PMID:31748741  PMCID:PMC6895438
    • Sanchez-Alavez, M., Nguyen, W., Mori, S., Wills, D. N., Otero, D., Aguirre, C. A., Singh, M., Ehlers, C. L., Conti, B. Time course of blood and brain cytokine/chemokine levels following adolescent alcohol exposure and withdrawal in rats Alcoholism-Clinical and Experimental Research  2019  DOI:10.1111/acer.14209  PMID:31589333
    • Conti, B. A mouse model to investigate the effects of lifestyle on vascular dementia and Alzheimer's disease? Brain Behavior and Immunity  2019 79:20-21  DOI:10.1016/j.bbi.2019.04.020  PMID:30980949
    • Sanchez-Alavez, M., Nguyen, W., Mori, S., Wills, D. N., Otero, D., Ehlers, C. L., Conti, B. Time course of microglia activation and brain and blood cytokine/chemokine levels following chronic ethanol exposure and protracted withdrawal in rats Alcohol  2019 76:37-45  DOI:10.1016/j.alcohol.2018.07.005  PMID:30554034  PMCID:PMC6336521
    • Amodeo, L. R., Wills, D. N., Sanchez-Alavez, M., Nguyen, W., Conti, B., Ehlers, C. L. Intermittent voluntary ethanol consumption combined with ethanol vapor exposure during adolescence increases drinking and alters other behaviors in adulthood in female and male rats Alcohol  2018 73:57-66  DOI:10.1016/j.alcohol.2018.04.003  PMID:30293056  PMCID:PMC6193864
    • Maher, P., Conti, B. Deciphering the pathways that protect from IL-13-mediated potentiation of oxidative stress-induced dopaminergic nerve cell death Cytokine  2018 103:114-120  DOI:10.1016/j.cyto.2017.09.018  PMID:28969943  PMCID:PMC5808859
    • Cintron-Colon, R., Sanchez-Alavez, M., Nguyen, W., Mori, S., Gonzalez-Rivera, R., Lien, T., Bartfai, T., Aid, S., Francois, J. C., Holzenbergerf, M., Conti, B. Insulin-like growth factor 1 receptor regulates hypothermia during calorie restriction Proceedings of the National Academy of Sciences of the United States of America  2017 114:9731-9736  DOI:10.1073/pnas.1617876114  PMID:28827363
    • Carvalho, G. B., Drago, I., Hoxha, S., Yamada, R., Mahneva, O., Bruce, K. D., Obando, A. S., Conti, B., Ja, W. W. The 4E-BP growth pathway regulates the effect of ambient temperature on Drosophila metabolism and lifespan Proceedings of the National Academy of Sciences of the United States of America  2017 114:9737-9742  DOI:10.1073/pnas.1618994114  PMID:28827349
    • Mori, S., Sugama, S., Nguyen, W., Michel, T., Sanna, M. G., Sanchez-Alavez, M., Cintron-Colon, R., Moroncini, G., Kakinuma, Y., Maher, P., Conti, B. Lack of interleukin-13 receptor α1 delays the loss of dopaminergic neurons during chronic stress Journal of Neuroinflammation  2017 14  DOI:10.1186/s12974-017-0862-1  PMID:28427412  PMCID:PMC5399344
    • Bortell, N., Flynn, C., Conti, B., Fox, H. S., Marcondes, M. C. G. Osteopontin impacts West Nile virus pathogenesis and resistance by regulating inflammasome components and cell death in the central nervous system at early time points Mediators of Inflammation  2017  DOI:10.1155/2017/7582437  PMID:28811681  PMCID:PMC5547729
    • Francesconi, W., Sanchez-Alavez, M., Berton, F., Alboni, S., Benatti, C., Mori, S., Nguyen, W., Zorrilla, E., Moroncini, G., Tascedda, F., Conti, B. The proinflammatory cytokine interleukin 18 regulates feeding by acting on the bed nucleus of the stria terminalis Journal of Neuroscience  2016 36:5170-5180  DOI:10.1523/jneurosci.3919-15.2016  PMID:27147667
    • Viader, A., Ogasawara, D., Joslyn, C. M., Sanchez-Alavez, M., Mori, S., Nguyen, W., Conti, B., Cravatt, B. F. A chemical proteomic atlas of brain serine hydrolases identifies cell type-specific pathways regulating neuroinflammation Elife  2016 5  DOI:10.7554/eLife.12345  PMID:26779719  PMCID:PMC4737654
    • Ogasawara, D., Deng, H., Viader, A., Baggelaar, M. P., Breman, A., den Dulk, H., van den Nieuwendijk, A. M. C. H. and Soethoudt, M., van der Wel, T., Zhou, J., Overkleeft, H. S., Sanchez-Alavez, M., Mo, S., et al. Rapid and profound rewiring of brain lipid signaling networks by acute diacylglycerol lipase inhibition Proceedings of the National Academy of Sciences of the United States of America  2016 113:26  DOI:10.1073/pnas.1522364112  PMID:26668358  PMCID:PMC4711871
    • Sugama, S., Sekiyama, K., Kodama, T., Takamatsu, Y., Takenouchi, T., Hashimoto, M., Bruno, C., Kakinuma, Y. Chronic restraint stress triggers dopaminergic and noradrenergic neurodegeneration: Possible role of chronic stress in the onset of Parkinson's disease Brain Behavior and Immunity  2016 51:39-46  DOI:10.1016/j.bbi.2015.08.015  PMID:26291405  PMCID:PMC4849407
    • Hale, M. W., Spencer, S. J., Conti, B., Jasoni, C. L., Kent, S., Radler, M. E., Reyes, T. M., Sominsky, L. Diet, behavior and immunity across the lifespan Neuroscience and Biobehavioral Reviews  2015 58:46-62  DOI:10.1016/j.neubiorev.2014.12.009  PMID:25524877
    • Sanchez-Alavez, M., Nguyen, W., Mori, S., Moroncini, G., Viader, A., Nomura, D. K., Cravatt, B. F., Conti, B. Monoacylglycerol lipase regulates fever response PLoS One  2015 10:e0134437  DOI:10.1371/journal.pone.0134437  PMID:26287872  PMCID:PMC4543552
    • Alboni, S., Montanari, C., Benatti, C., Sanchez-Alavez, M., Rigillo, G., Blom, J. M. C., Brunello, N., Conti, B., Pariante, M. C., Tascedda, F. Interleukin 18 activates MAPKs and STAT3 but not NF-kappa B in hippocampal HT-22 cells Brain Behavior and Immunity  2014 40:85-94  DOI:10.1016/j.bbi.2014.02.015  PMID:24603356
    • Zorrilla, E. P., Conti, B. Interleukin-18 null mutation increases weight and food intake and reduces energy expenditure and lipid substrate utilization in high-fat diet fed mice Brain Behavior and Immunity  2014 37:45-53  DOI:10.1016/j.bbi.2013.12.001  PMID:24316258  PMCID:PMC4219830
    • Marcondes, M. C. G., Ojakian, R., Bortell, N., Flynn, C., Conti, B., Fox, H. S. Osteopontin expression in the brain triggers localized inflammation and cell death when immune cells are activated by pertussis toxin Mediators of Inflammation  2014 358218  DOI:10.1155/2014/358218  PMID:25525298  PMCID:PMC4265371
    • Sanchez-Alavez, M., Conti, B., Wood, M. R., Bortell, N., Bustamante, E., Saez, E., Fox, H. S., Marcondes, M. C. ROS and sympathetically mediated mitochondria activation in brown adipose tissue contribute to methamphetamine-induced hyperthermia Frontiers in Endocrinology  2013 4:44-10735  DOI:10.3389/fendo.2013.00044  PMID:23630518  PMCID:PMC3632801
    • Sugama, S., Takenouchi, T., Fujita, M., Kitani, H., Conti, B., Hashimoto, M. Corticosteroids limit microglial activation occurring during acute stress Neuroscience  2013 232:13-20  DOI:10.1016/j.neuroscience.2012.12.012  PMID:23262242
    • Conti, B., Hansen, M. A cool way to live long Cell  2013 152:671-672  DOI:10.1016/j.cell.2013.01.050  PMID:23415218
    • Morrison, B. E., Marcondes, M. C. G., Nomura, D. K., Sanchez-Alavez, M., Sanchez-Gonzalez, A., Saar, I., Kim, K. S., Bartfai, T., Maher, P., Sugama, S., Conti, B. Cutting edge: IL-13Rα1 expression in dopaminergic neurons contributes to their oxidative stress-mediated loss following chronic peripheral treatment with lipopolysaccharide Journal of Immunology  2012 189:5498-5502  DOI:10.4049/jimmunol.1102150  PMID:23169588  PMCID:PMC3545403
    • Dubins, J. S., Sanchez-Alavez, M., Zhukov, V., Sanchez-Gonzalez, A., Moroncini, G., Carvajal-Gonzalez, S., Hadcock, J. R., Bartfai, T., Conti, B. Downregulation of GPR83 in the hypothalamic preoptic area reduces core body temperature and elevates circulating levels of adiponectin Metabolism-Clinical and Experimental  2012 61:1486-1493  DOI:10.1016/j.metabol.2012.03.015  PMID:22560055  PMCID:PMC3415578
    • Bartfai, T., Conti, B. Molecules affecting hypothalamic control of core body temperature in response to calorie intake Frontiers in Genetics  2012 3:184  DOI:10.3389/fgene.2012.00184  PMID:23097647  PMCID:PMC3466567
    • Klein, I., Sanchez-Alavez, M., Tabarean, I., Schaefer, J., Holmberg, K. H., Klaus, J., Xia, F. C., Marcondes, M. C. G., Dubins, J. S., Morrison, B., Zhukov, V., Sanchez-Gonzalez, A., et al. AdipoR1 and 2 are expressed on warm sensitive neurons of the hypothalamic preoptic area and contribute to central hyperthermic effects of adiponectin Brain Research  2011 1423:1-9  DOI:10.1016/j.brainres.2011.09.019  PMID:22000082  PMCID:PMC3215583
    • Nomura, D. K., Morrison, B. E., Blankman, J. L., Long, J. Z., Kinsey, S. G., Marcondes, M. C. G., Ward, A. M., Hahn, Y. K., Lichtman, A. H., Conti, B., Cravatt, B. F. Endocannabinoid hydrolysis generates brain prostaglandins that promote neuroinflammation Science  2011 334:809-813  DOI:10.1126/science.1209200  PMID:22021672  PMCID:PMC3249428
    • Marcondes, M. C. G., Zhukov, V., Bradlow, H., Sanchez-Alavez, M., Gonzalez, A. S. A., Curtiss, L. K., Conti, B. Effects of chronic mental stress and atherogenic diet on the immune inflammatory environment in mouse aorta Brain Behavior and Immunity  2011 25:1649-1657  DOI:10.1016/j.bbi.2011.06.007  PMID:21722726  PMCID:PMC3191305
    • Sabino, V., Cottone, P., Blasio, A., Iyer, M. R., Steardo, L., Rice, K. C., Conti, B., Koob, G. F., Zorrilla, E. P. Activation of σ-receptors induces binge-like drinking in Sardinian alcohol-preferring rats Neuropsychopharmacology  2011 36:1207-1218  DOI:10.1038/npp.2011.5  PMID:21346735  PMCID:PMC3079320
    • Takenouchi, T., Iwamaru, Y., Sugama, S., Tsukimoto, M., Fujita, M., Sekigawa, A., Sekiyama, K., Sato, M., Kojima, S., Conti, B., Hashimoto, M., Kitani, H. The activation of P2X7 receptor induces cathepsin D-dependent production of a 20-kDa form of IL-1 beta under acidic extracellular pH in LPS-primed microglial cells Journal of Neurochemistry  2011 117:712-723  DOI:10.1111/j.1471-4159.2011.07240.x  PMID:21395581
    • Alboni, S., Montanari, C., Benatti, C., Blom, J. M. C., Simone, M. L., Brunello, N., Caggia, F., Guidotti, G., Marcondes, M. C. G., Sanchez-Alavez, M., Conti, B., Tascedda, F. Constitutive and LPS-regulated expression of interleukin-18 receptor beta variants in the mouse brain Brain Behavior and Immunity  2011 25:483-493  DOI:10.1016/j.bbi.2010.11.011  PMID:21111041
    • Sanchez-Alavez, M., Alboni, S., Conti, B. Sex- and age-specific differences in core body temperature of C57Bl/6 mice Age  2011 33:89-99  DOI:10.1007/s11357-010-9164-6  PMID:20635153  PMCID:PMC3063645
    • Dinarello, C., Arend, W., Sims, J., Smith, D., Blumberg, H., O'Neill, L., Goldbach-Mansky, R., Pizarro, T., Hoffman, H., Bufler, P., Nold, M., Ghezzi, P., et al. IL-1 family nomenclature Nature Immunology  2010 11:973  DOI:10.1038/ni1110-973  PMID:20959797  PMCID:PMC4174560
    • Ali, S. S., Marcondes, M. C. G., Bajova, H., Dugan, L. L., Conti, B. Metabolic depression and increased reactive oxygen species production by isolated mitochondria at moderately lower temperatures Journal of Biological Chemistry  2010 285:32522-32528  DOI:10.1074/jbc.M110.155432  PMID:20716522  PMCID:PMC2952254
    • Brownell, S. E., Conti, B. Age- and gender-specific changes of hypocretin immunopositive neurons in C57Bl/6 mice Neuroscience Letters  2010 472:29-32  DOI:10.1016/j.neulet.2010.01.048  PMID:20117171  PMCID:PMC2830316
    • Alboni, S., Cervia, D., Sugama, S., Conti, B. Interleukin 18 in the CNS Journal of Neuroinflammation  2010 7:9  DOI:10.1186/1742-2094-7-9  PMID:20113500  PMCID:PMC2830964
    • Bartfai, T., Conti, B. Fever Thescientificworldjournal  2010 10:490-503  DOI:10.1100/tsw.2010.50  PMID:20305990  PMCID:PMC2850202
    • Tabarean, I., Morrison, B., Marcondes, M. C., Bartfai, T., Conti, B. Hypothalamic and dietary control of temperature-mediated longevity Ageing Research Reviews  2010 9:41-50  DOI:10.1016/j.arr.2009.07.004  PMID:19631766  PMCID:PMC2818054
    • Sanchez-Alavez, M., Tabarean, I. V., Osborn, O., Mitsukawa, K., Schaefer, J., Dubins, J., Holmberg, K. H., Klein, I., Klaus, J., Gomez, L. F., Kolb, H., Secrest, J., et al. Insulin causes hyperthermia by direct inhibition of warm-sensitive neurons Diabetes  2010 59:43-50  DOI:10.2337/db09-1128  PMID:19846801  PMCID:PMC2797943
    • Osborn, O., Sanchez-Alavez, M., Brownell, S. E., Ross, B., Klaus, J., Dubins, J., Beutler, B., Conti, B., Bartfai, T. Metabolic characterization of a mouse deficient in all known leptin receptor isoforms Cellular and Molecular Neurobiology  2010 30:23-33  DOI:10.1007/s10571-009-9427-x  PMID:19582570  PMCID:PMC2813927
    • Cottone, P., Sabino, V., Roberto, M., Bajo, M., Pockros, L., Frihauf, J. B., Fekete, E. M., Steardo, L., Rice, K. C., Grigoriadis, D. E., Conti, B., Koob, G. F., et al. CRF system recruitment mediates dark side of compulsive eating Proceedings of the National Academy of Sciences of the United States of America  2009 106:20016-20020  DOI:10.1073/pnas.0908789106  PMID:19901333  PMCID:PMC2785284
    • Alboni, S., Cervia, D., Ross, B., Montanari, C., Gonzalez, A. S., Sanchez-Alavez, M., Marcondes, M. C. G., De Vries, D., Sugama, S., Brunello, N., Blom, J., Tascedda, F., et al. Mapping of the full length and the truncated interleukin-18 receptor alpha in the mouse brain Journal of Neuroimmunology  2009 214:43-54  DOI:10.1016/j.jneuroim.2009.06.016  PMID:19640592  PMCID:PMC2745497
    • Sabino, V., Cottone, P., Zhao, Y., Iyer, M. R., Steardo, L., Rice, K. C., Conti, B., Rice, K. C., Koob, G. F., Zorrilla, E. P. The sigma-receptor antagonist BD-1063 decreases ethanol intake and reinforcement in animal models of excessive drinking Neuropsychopharmacology  2009 34:1482-1493  DOI:10.1038/npp.2008.192  PMID:18946467  PMCID:PMC2669694
    • Sugama, S., Takenouchi, T., Fujita, M., Conti, B., Hashimoto, M. Differential microglial activation between acute stress and lipopolysaccharide treatment Journal of Neuroimmunology  2009 207:24-31  DOI:10.1016/j.jneuroim.2008.11.007  PMID:19111355
    • Osborn, O., Gramm, H., Zorrilla, E. P., Conti, B., Bartfai, T. Insights into the roles of the inflammatory mediators IL-1, IL-18 and PGE2 in obesity and insulin resistance Swiss Medical Weekly  2008 138:665-673  PMID:18855149
    • Sanchez-Alavez, M., Criado, J. R., Klein, I., Moroncini, G., Conti, B. Hypothalamic-pituitary-adrenal axis disregulation in PrPC-null mice Neuroreport  2008 19:1473-1477  DOI:10.1097/WNR.0b013e32830fle90  PMID:18797300  PMCID:PMC2649708
    • Conti, B. Considerations on temperature, longevity and aging Cellular and Molecular Life Sciences  2008 65:1626-1630  DOI:10.1007/s00018-008-7536-1  PMID:18425417  PMCID:PMC2574693
    • Sugama, S., Conti, B. Interleukin-18 and stress Brain Research Reviews  2008 58:85-95  DOI:10.1016/j.brainresrev.2007.11.003  PMID:18295340
    • Conti, B., Tabarean, I., Sanchez-Alavez, M., Davis, C., Brownell, S., Behrens, M., Bartfai, T. Cytokine receptors in the brain Neuroimmune Biology  2008 6:19-28  DOI:10.1016/S1567-7443(07)10002-8
    • Sanchez-Alavez, M., Conti, B., Moroncini, G., Criado, J. R. Contributions of neuronal prion protein on sleep recovery and stress response following sleep deprivation Brain Research  2007 1158:71-80  DOI:10.1016/j.brainres.2007.05.010  PMID:17570349  PMCID:PMC1994827
    • Zorriila, E. P., Sanchez-Alavez, M., Sugama, S., Brennan, M., Fernandez, R., Bartfai, T., Conti, B. Interleukin-18 controls energy homeostasis by suppressing appetite and feed efficiency Proceedings of the National Academy of Sciences of the United States of America  2007 104:11097-11102  DOI:10.1073/pnas.0611523104  PMID:17578927  PMCID:PMC1904154
    • Sanchez-Alavez, M., Klein, I., Brownell, S. E., Tabarean, I. V., Davis, C. N., Conti, B., Bartfai, T. Night eating and obesity in the EP3R-deficient mouse Proceedings of the National Academy of Sciences of the United States of America  2007 104:3009-3014  DOI:10.1073/pnas.0611209104  PMID:17307874  PMCID:PMC1800735
    • Sugama, S., Fujita, M., Hashimoto, M., Conti, B. Stress induced morphological microglial activation in the rodent brain: Involvement of interleukin-18 Neuroscience  2007 146:1388-1399  DOI:10.1016/j.neuroscience.2007.02.043  PMID:17433555
    • Sotgiu, S., Sannella, A. R., Conti, B., Arru, G., Fois, M. L., Sanna, A., Severini, C., Morale, M. C., Marchetti, B., Rosati, G., Musumeci, S. Multiple sclerosis and anti-Plasmodium falciparum innate immune response Journal of Neuroimmunology  2007 185:201-207  DOI:10.1016/j.jneuroim.2007.01.020  PMID:17336397
    • Conti, B., Maier, R., Barr, A. M., Morale, M. C., Lu, X., Sanna, P. P., Bilbe, G., Hoyer, D., Bartfai, T. Region-specific transcriptional changes following the three antidepressant treatments electro convulsive therapy, sleep deprivation and fluoxetine Molecular Psychiatry  2007 12:167-189  DOI:10.1038/sj.mp.4001897  PMID:17033635
    • Bartfai, T., Sanchez-Alavez, M., Andell-Jonsson, S., Schultzberg, M., Vezzani, A., Danielsson, E., Conti, B. Interleukin-1 system in CNS stress: seizures, fever, and neurotrauma Annals of the New York Academy of Sciences  2007 1113:173-177  DOI:10.1196/annals.1391.022  PMID:17656565
    • Sanna, M. V., Clemente, M. G., Bartfai, T., Conti, B., Sanna, P. P. Potential role for the plague as a selective forse in Sardinia L'igiene Moderna  2007 127:15-42
    • Conti, B., Sanchez-Alavez, M., Winsky-Sommerer, R., Morale, M. C., Lucero, J., Brownell, S., Fabre, V., Huitron-Resendiz, S., Henriksen, S., Zorrilla, E. P., de Lecea, L., Bartfai, T. Transgenic mice with a reduced core body temperature have an increased life span Science  2006 314:825-828  DOI:10.1126/science.1132191  PMID:17082459
    • Wang, N., Sugama, S., Conti, B., Teramoto, A., Shibasaki, T. Interleukin-18 mRNA expression in the rat pituitary gland Journal of Neuroimmunology  2006 173:117-125  DOI:10.1016/j.jneuroim.2005.12.009  PMID:16460811
    • Sugama, S., Wang, N., Shimokawa, N., Koibuchi, N., Fujita, M., Hashimoto, M., Dhabhar, F. S., Conti, B. The adrenal gland is a source of stress-induced circulating IL-18 Journal of Neuroimmunology  2006 172:59-65  DOI:10.1016/j.jneuroim.2005.11.001  PMID:16359733
    • Kinney, J. W., Davis, C. N., Tabarean, I., Conti, B., Bartfai, T., Behrens, M. M. A specific role for NR2A-containing NMDA receptors in the maintenance of parvalbumin and GAD67 immunoreactivity in cultured interneurons Journal of Neuroscience  2006 26:1604-1615  DOI:10.1523/jneurosci.4722-05.2006  PMID:16452684
    • Criado, J. R., Sanchez-Alavez, M., Conti, B., Giacchino, J. L., Wills, D. N., Henriksen, S. J., Race, R., Manson, J. C., Chesebro, B., Oldstone, M. B. A. Mice devoid of prion protein have cognitive deficits that are rescued by reconstitution of PrP in neurons Neurobiology of Disease  2005 19:255-265  DOI:10.1016/j.nbd.2004.01.001  PMID:15837581
    • Conti, B., Sugama, S., Lucero, J., Winsky-Sommerer, R., Wirz, S. A., Maher, P., Andrews, Z., Barr, A. M., Morale, M. C., Paneda, C., Pemberton, J., Gaidarova, S., et al. Uncoupling protein 2 protects dopaminergic neurons from acute 1,2,3,6-methyl-phenyl-tetrahydropyridine toxicity Journal of Neurochemistry  2005 93:493-501  DOI:10.1111/j.1471-4159.2005.03052.x  PMID:15816872
    • Lu, X. Y., Barr, A. M., Kinney, J. W., Sanna, P., Conti, B., Behrens, M. M., Bartfai, T. A role for galanin in antidepressant actions with a focus on the dorsal raphe nucleus Proceedings of the National Academy of Sciences of the United States of America  2005 102:874-879  DOI:10.1073/pnas.0408891102  PMID:15647369  PMCID:PMC545581
    • Tabarean, I. V., Conti, B., Behrens, M., Korn, H., Bartfai, T. Electrophysiological properties and thermosensitivity of mouse preoptic and anterior hypothalamic neurons in culture Neuroscience  2005 135:433-449  DOI:10.1016/j.neuroscience.2005.06.053  PMID:16112471
    • Wirz, S. A., Morale, M. C., Marchetti, B., Barr, A. M., Sotgiu, S., Rosati, G., Pugliatti, M., Sanna, M. V., Giliberto, O., Bartfai, T., Conti, B. High frequency of TNF alleles -238A and -376A in individuals from northern Sardinia Cytokine  2004 26:149-154  DOI:10.1016/j.cyto.2004.02.006  PMID:15149631
    • Conti, B., Tabarean, I., Andrei, C., Bartfai, T. Cytokines and fever Frontiers in Bioscience  2004 9:1433-1449  DOI:10.2741/1341  PMID:14977558
    • Solforosi, L., Criado, J. R., McGavern, D. B., Wirz, S., Sanchez-Alavez, M., Sugama, S., DeGiorgio, L. A., Volpe, B. T., Wiseman, E., Abalos, G., Masliah, E., Gilden, D., et al. Cross-linking cellular prion protein triggers neuronal apoptosis in vivo Science  2004 303:1514-1516  DOI:10.1126/science.1094273  PMID:14752167
    • Sugama, S., Wirz, S. A., Barr, A. M., Conti, B., Bartfai, T., Shibasaki, T. Interleukin-18 null mice show diminished microglial activation and reduced dopaminergic neuron loss following acute 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine treatment Neuroscience  2004 128:451-458  DOI:10.1016/j.neuroscience.2004.07.020  PMID:15350655
    • Sugama, S., Cho, B. P., Baker, H., Joh, T. H., Lucero, J., Conti, B. Neurons of the superior nucleus of the medial habenula and ependymal cells express IL-18 in rat CNS Brain Research  2002 958:1-9  DOI:10.1016/s0006-8993(02)03363-2  PMID:12468024
    • Sugama, S., Kim, Y. S., Baker, H., Tinti, C., Kim, H., Joh, T. H., Conti, B. Tissue-specific expression of rat IL-18 gene and response to adrenocorticotropic hormone treatment Journal of Immunology  2000 165:6287-6292  PMID:11086064
    • DeGiorgio, L. A., DeGiorgio, N., Milner, T. A., Conti, B., Volpe, B. T. Neurotoxic APP C-terminal and beta-amyloid domains colocalize in the nuclei of substantia nigra pars reticulata neurons undergoing delayed degeneration Brain Research  2000 874:137-146  DOI:10.1016/s0006-8993(00)02545-2  PMID:10960598
    • Conti, B., Sugama, S., Kim, Y., Tinti, C., Kim, H., Baker, H., Volpe, B., Attardi, B., Joh, T. Modulation of IL-18 production in the adrenal cortex following acute ACTH or chronic corticosterone treatment Neuroimmunomodulation  2000 8:1-7  DOI:10.1159/000026445  PMID:10859481
    • Conti, B., Park, L. C. H., Calingasan, N. Y., Kim, Y., Kim, H., Bae, Y., Gibson, G. E., Joh, T. H. Cultures of astrocytes and microglia express interleukin 18 Molecular Brain Research  1999 67:46-52  DOI:10.1016/s0169-328x(99)00034-0  PMID:10101231
    • Liu, N., Cigola, E., Tinti, C., Jin, B. K., Conti, B., Volpe, B. T., Baker, H. Unique regulation of immediate early gene and tyrosine hydroxylase expression in the odor-deprived mouse olfactory bulb Journal of Biological Chemistry  1999 274:3042-3047  DOI:10.1074/jbc.274.5.3042  PMID:9915843
    • Son, J. H., Chun, H. S., Joh, T. H., Cho, S., Conti, B., Lee, J. W. Neuroprotection and neuronal differentiation studies using substantia nigra dopaminergic cells derived from transgenic mouse embryos Journal of Neuroscience  1999 19:10-20  PMID:9870933
    • Tinti, C., Yang, C. Y., Seo, H., Conti, B., Kim, C., Joh, T. H., Kim, K. S. Structure/function relationship of the cAMP response element in tyrosine hydroxylase gene transcription Journal of Biological Chemistry  1997 272:19158-19164  DOI:10.1074/jbc.272.31.19158  PMID:9235905
    • Olikowsky, T., Wang, Z. Q., Dudhane, A., Horowitz, H., Conti, B., Hoffmann, M. K. Two distinct pathways of human macrophage differentiation are mediated by interferon-gamma and interleukin-10 Immunology  1997 91:104-108  DOI:10.1046/j.1365-2567.1997.00204.x  PMID:9203972  PMCID:PMC1364041
    • Conti, B., Jahng, J. W., Tinti, C., Son, J. H., Joh, T. H. Induction of interferon-gamma inducing factor in the adrenal cortex Journal of Biological Chemistry  1997 272:2035-2037  PMID:8999896
    • Orlikowsky, T., Wang, Z. Q., Dudhane, A., Horowitz, H., Conti, B., Hoffmann, M. The cell surface marker phenotype of macrophages from HIV-1-infected subjects reflects an IL-10-enriched and IFN-gamma-deprived donor environment Journal of Interferon and Cytokine Research  1996 16:957-962  DOI:10.1089/jir.1996.16.957  PMID:8938573
    • Jin, B. K., Belloni, M., Conti, B., Federoff, H. J., Starr, R., Son, J. H., Baker, H., Joh, T. H. Prolonged in vivo gene expression driven by a tyrosine hydroxylase promoter in a defective herpes simplex virus amplicon vector Human Gene Therapy  1996 7:2015-2024  DOI:10.1089/hum.1996.7.16-2015  PMID:8930662
    • Tinti, C., Conti, B., Cubells, J. F., Kim, K. S., Baker, H., Joh, T. H. Inducible cAMP early repressor can modulate tyrosine hydroxylase gene expression after stimulation of cAMP synthesis Journal of Biological Chemistry  1996 271:25375-25381  PMID:8810303
    • Dudhane, A., Conti, B., Orlikowsky, T., Wang, Z. Q., Mangla, N., Gupta, A., Wormser, G. P., Hoffmann, M. K. Monocytes in HIV type 1-infected individuals lose expression of costimulatory B7 molecules and acquire cytotoxic activity AIDS Research and Human Retroviruses  1996 12:885-892  DOI:10.1089/aid.1996.12.885  PMID:8798973

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Research

research overview

  • Our laboratory is interested in the biological role of cytokines in the central nervous system and in the role of central thermoregulation in energy homeostasis and aging.

    In particular, we are investigating the biology of interleukin 18 (IL-18) and of interleukin 13 (IL-13) in the central nervous system (CNS).  These cytokines can participate in local inflammatory processes affecting neuronal survival and neurodegenerative diseases. In addition, since the IL-18, as well as the IL-13 receptors, is expressed in neurons, these interleukins can directly influence central functions and behavior. For instance, we previously demonstrated that IL-18 participates in the regulation of energy homeostasis by influencing feeding and energy efficiency. Using molecular techniques and animal models we hope to characterize the biology of these cytokines in the CNS and its significance in health and disease.

    In addition, the laboratory is also actively investigating the central mechanisms of thermoregulation and its involvement in influencing energy homeostasis and aging. We showed that small but prolonged reduction of core body temperature prolongs lifespan. We are now actively investigating the mechanisms mediating these effects.

keywords

  • metabolomics
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Teaching

advisees

  • graduate advising relationship

    • Aguirre, Carlos Andres, Ph.D.  candidate, 2017 -
    • Cintron-Colon, Rigo Giovani, Ph.D.  candidate, 2015 - 2019
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Background

education and training

  • Ph.D., University of Milan 1990
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Contact

full name

  • Bruno Conti

geographic location

  • Scripps California 

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