Contet, Candice

Faculty Member

Positions

2017 - Associate Professor, Neuroscience , Scripps Research
2008 - Faculty Member, Skaggs Graduate School of Chemical and Biological Sciences , Scripps Research
2016 - 2017 Associate Professor, Committee on the Neurobiology of Addictive Disorders (CNAD) , Scripps Research
2008 - 2016 Assistant Professor, Committee on the Neurobiology of Addictive Disorders (CNAD) , Scripps Research

Research Areas

Addiction (UMLS)

Contact

contet@scripps.edu

Websites

Candice Contet, Ph.D.

Publications
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recent publications

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academic article
- Kimbrough, A., Lurie, D. J., Collazo, A., Kreifeldt, M., Sidhu, H., Macedo, G. C., D'Esposito, M., Contet, C., George, O. Brain-wide functional architecture remodeling by alcohol dependence and abstinence Proceedings of the National Academy of Sciences of the United States of America 2020 117:2149-2159 DOI:10.1073/pnas.1909915117 PMID:31937658 PMCID:PMC6994986
- Goulding, S. P., de Guglielmo, G., Carrette, L. L. G., George, O., Contet, C. Systemic administration of the cyclin-dependent kinase inhibitor (S)-CR8 selectively reduces escalated ethanol intake in dependent rats Alcoholism-Clinical and Experimental Research 2019 DOI:10.1111/acer.14177 PMID:31403700
- Sidhu, H., Kreifeldt, M., Contet, C. Affective disturbances during withdrawal from chronic intermittent ethanol inhalation in C57BL/6J and DBA/2J male mice Alcoholism-Clinical and Experimental Research 2018 42:1281-1290 DOI:10.1111/acer.13760 PMID:29687895 PMCID:PMC6028290
- Schmeichel, B. E., Matzeu, A., Koebel, P., Vendruscolo, L. F., Sidhu, H., Shahryari, R., Kieffer, B. L., Koob, G. F., Martin-Fardon, R., Contet, C. Knockdown of hypocretin attenuates extended access of cocaine self-administration in rats Neuropsychopharmacology 2018 43:2373-2382 DOI:10.1038/s41386-018-0054-4 PMID:29703996 PMCID:PMC6180106
- Verheij, M. M. M., Contet, C., Karel, P., Latour, J., van der Doelen, R. H. A., Geenen, B., van Hulten, J. A., Meyer, F., Kozicz, T., George, O., Koob, G. F., Homberg, J. R. Median and dorsal raphe serotonergic neurons control moderate versus compulsive cocaine intake Biological Psychiatry 2018 83:1024-1035 DOI:10.1016/j.biopsych.2017.10.031 PMID:29357981 PMCID:PMC5960600
- Varodayan, F. P., Sidhu, H., Kreifeldt, M., Roberto, M., Contet, C. Morphological and functional evidence of increased excitatory signaling in the prelimbic cortex during ethanol withdrawal Neuropharmacology 2018 133:470-480 DOI:10.1016/j.neuropharm.2018.02.014 PMID:29471053 PMCID:PMC5865397
- Goulding, S. P., Szumlinski, K. K., Contet, C., MacCoss, M. J., Wu, C. C. A mass spectrometry-based proteomic analysis of Homer2-interacting proteins in the mouse brain Journal of Proteomics 2017 166:127-137 DOI:10.1016/j.jprot.2017.07.008 PMID:28728878
- Somkuwar, S. S., Vendruscolo, L. F., Fannon, M. J., Schmeichel, B. E., Nguyen, T. B., Guevara, J., Sidhu, H., Contet, C., Zorrilla, E. P., Mandyam, C. D. Abstinence from prolonged ethanol exposure affects plasma corticosterone, glucocorticoid receptor signaling and stress-related behaviors Psychoneuroendocrinology 2017 84:17-31 DOI:10.1016/j.psyneuen.2017.06.006 PMID:28647675 PMCID:PMC5557646
- Herman, M. A., Contet, C., Roberto, M. A functional switch in tonic GABA currents alters the output of central amygdala corticotropin releasing factor receptor-1 neurons following chronic ethanol exposure Journal of Neuroscience 2016 36:10729-10741 DOI:10.1523/jneurosci.1267-16.2016 PMID:27798128 PMCID:PMC5083004
- Munoz, M. B., Padgett, C. L., Rifkin, R., Terunuma, M., Wickman, K., Contet, C., Moss, S. J., Slesinger, P. A. A role for the GIRK3 subunit in methamphetamine-induced aAttenuation of GABA(B) receptor-activated GIRK currents in VTA dopamine neurons Journal of Neuroscience 2016 36:3106-3114 DOI:10.1523/jneurosci.1327-15.2016 PMID:26985023 PMCID:PMC4792929
- Verheij, M. M. M., Vendruscolo, L. F., Caffino, L., Giannotti, G., Cazorla, M., Fumagalli, F., Riva, M. A., Homberg, J. R., Koob, G. F., Contet, C. Systemic Delivery of a Brain-Penetrant TrkB Antagonist Reduces Cocaine Self-Administration and Normalizes TrkB Signaling in the Nucleus Accumbens and Prefrontal Cortex Journal of Neuroscience 2016 36:8149-8159 DOI:10.1523/jneurosci.2711-14.2016 PMID:27488635 PMCID:PMC4971362
- Kreifeldt, M., Cates-Gatto, C., Roberts, A. J., Contet, C. BK channel β1 subunit contributes to behavioral adaptations elicited by chronic intermittent ethanol exposure Alcoholism-Clinical and Experimental Research 2015 39:2394 DOI:10.1111/acer.12911 PMID:26578345 PMCID:PMC4712106
- Herman, M. A., Sidhu, H., Stouffer, D. G., Kreifeldt, M., Le, D., Cates-Gatto, C., Munoz, M. B., Roberts, A. J., Parsons, L. H., Roberto, M., Wickman, K., Slesinger, P. A., et al. GIRK3 gates activation of the mesolimbic dopaminergic pathway by ethanol Proceedings of the National Academy of Sciences of the United States of America 2015 112:7091-7096 DOI:10.1073/pnas.1416146112 PMID:25964320 PMCID:PMC4460485
- Schmeichel, B. E., Barbier, E., Misra, K. K., Contet, C., Schlosburg, J. E., Grigoriadis, D., Williams, J. P., Karlsson, C., Pitcairn, C., Heilig, M., Koob, G. F., Vendruscolo, L. F. Hypocretin receptor 2 antagonism dose-dependently reduces escalated heroin self-administration in rats Neuropsychopharmacology 2015 40:1123-1129 DOI:10.1038/npp.2014.293 PMID:25367502 PMCID:PMC4367454
- Grieder, T. E., Herman, M. A., Contet, C., Tan, L. A., Vargas-Perez, H., Cohen, A., Chwalek, M., Maal-Bared, G., Freiling, J., Schlosburg, J. E., Clarke, L., Crawford, E., et al. VTA CRF neurons mediate the aversive effects of nicotine withdrawal and promote intake escalation Nature Neuroscience 2014 17:1751-1758 DOI:10.1038/nn.3872 PMID:25402857 PMCID:PMC4241147
- Cohen, A., Whitfield, T. W., Kreifeldt, M., Koebel, P., Kieffer, B. L., Contet, C., George, O., Koob, G. F. Virus-mediated shRNA knockdown of prodynorphin in the rat nucleus accumbens attenuates depression-like behavior and cocaine locomotor sensitization PLoS One 2014 9:e97216 DOI:10.1371/journal.pone.0097216 PMID:24816773 PMCID:PMC4016270
- Contet, C., Kim, A., Le, D., Iyengar, S. K., Kotzebue, R. W., Yuan, C. J., Kieffer, B. L., Mandyam, C. D. mu-Opioid receptors mediate the effects of chronic ethanol binge drinking on the hippocampal neurogenic niche Addiction Biology 2014 19:770-780 DOI:10.1111/adb.12040 PMID:23461397 PMCID:PMC3681911
- Kreifeldt, M., Le, D., Treistman, S. N., Koob, G. F., Contet, C. BK channel beta1 and beta4 auxiliary subunits exert opposite influences on escalated ethanol drinking in dependent mice Frontiers in Integrative Neuroscience 2013 7:105 DOI:10.3389/fnint.2013.00105 PMID:24416005 PMCID:PMC3874544
- Herman, M. A., Contet, C., Justice, N. J., Vale, W., Roberto, M. Novel subunit-specific tonic GABA currents and differential effects of ethanol in the central amygdala of CRF receptor-1 reporter mice Journal of Neuroscience 2013 33:3284-3298 DOI:10.1523/jneurosci.2490-12.2013 PMID:23426657 PMCID:PMC3711798
- Contet, C. Gene expression under the influence: transcriptional profiling of ethanol in the brain Current Psychopharmacology 2012 1:301-314 PMID:24078902 PMCID:PMC3783024
- Semenova, S., Contet, C., Roberts, A. J., Markou, A. Mice lacking the beta4 subunit of the nicotinic acetylcholine receptor show memory deficits, altered anxiety- and depression-like behavior, and diminished nicotine-induced analgesia Nicotine & Tobacco Research 2012 14:1346-1355 DOI:10.1093/ntr/nts107 PMID:22573727 PMCID:PMC3482014
- Contet, C., Gardon, O., Filliol, D., Becker, J. A. J., Koob, G. F., Kieffer, B. L. Identification of genes regulated in the mouse extended amygdala by excessive ethanol drinking associated with dependence Addiction Biology 2011 16:615-619 DOI:10.1111/j.1369-1600.2010.00304.x PMID:21392173 PMCID:PMC3139763
- Contet, C., Whisler, K. N., Jarrell, H., Kenny, P. J., Markou, A. Patterns of responding differentiate intravenous nicotine self-administration from responding for a visual stimulus in C57BL/6J mice Psychopharmacology 2010 212:283-299 DOI:10.1007/s00213-010-1950-4 PMID:20668842 PMCID:PMC2952765
- Homberg, J. R., Contet, C. Deciphering the interaction of the corticotropin-releasing factor and serotonin brain systems in anxiety-related disorders Journal of Neuroscience 2009 29:13743-13745 DOI:10.1523/jneurosci.4362-09.2009 PMID:19889985 PMCID:PMC2799301
- Scherrer, G., Imamachi, N., Cao, Y. Q., Contet, C., Mennicken, F., O'Donnell, D., Kieffer, B. L., Basbaum, A. I. Dissociation of the opioid receptor mechanisms that control mechanical and heat pain Cell 2009 137:1148-1159 DOI:10.1016/j.cell.2009.04.019 PMID:19524516 PMCID:PMC3683597
- Contet, C., Filliol, D., Matifas, A., Kieffer, B. L. Morphine-induced analgesic tolerance, locomotor sensitization and physical dependence do not require modification of mu opioid receptor, cdk5 and adenylate cyclase activity Neuropharmacology 2008 54:475-486 DOI:10.1016/j.neuropharm.2007.10.015 PMID:18082850
- Contet, C., Dierich, A., Kieffer, B. L. Knock-in mice reveal nonsense-mediated mRNA decay in the brain Genesis 2007 45:38-43 DOI:10.1002/dvg.20263 PMID:17216605
- Contet, C., Gaveriaux-Ruff, C., Matifas, A., Caradec, C., Champy, M. F., Kieffer, B. L. Dissociation of analgesic and hormonal responses to forced swim stress using opioid receptor knockout mice Neuropsychopharmacology 2006 31:1733-1744 DOI:10.1038/sj.npp.1300934 PMID:16237385
- Grillet, N., Pattyn, A., Contet, C., Kieffer, B. L., Goridis, C., Brunet, J. F. Generation and characterization of Rgs4 mutant mice Molecular and Cellular Biology 2005 25:4221-4228 DOI:10.1128/mcb.25.10.4221-4228.2005 PMID:15870291 PMCID:PMC1087729
- Contet, C., Kieffer, B. L., Befort, K. Mu opioid receptor: a gateway to drug addiction Current Opinion in Neurobiology 2004 14:370-378 DOI:10.1016/j.conb.2004.05.005 PMID:15194118
- Contet, C., Matifas, A., Kieffer, B. L. No evidence for G-protein-coupled epsilon receptor in the brain of triple opioid receptor knockout mouse European Journal of Pharmacology 2004 492:131-136 DOI:10.1016/j.ejphar.2004.03.056 PMID:15178356
- Scherrer, G., Befort, K., Contet, C., Becker, J., Matifas, A., Kieffer, B. L. The delta agonists DPDPE and deltorphin II recruit predominantly mu receptors to produce thermal analgesia: a parallel study of mu, delta and combinatorial opioid receptor knockout mice European Journal of Neuroscience 2004 19:2239-2248 DOI:10.1111/j.0953-816X.2004.03339.x PMID:15090050
- Contet, C., Rawlins, J. N. P., Deacon, R. M. J. A comparison of 129S2/SvHsd and C57BL/6JO1aHsd mice on a test battery assessing sensorimotor, affective and cognitive behaviours: implications for the study of genetically modified mice Behavioural Brain Research 2001 124:33-46 DOI:10.1016/s0166-4328(01)00231-5 PMID:11423164
- Contet, C., Rawlins, J. N. P., Bannerman, D. M. Faster is not surer: a comparison of C57BL/6J and 129S2/Sv mouse strains in the watermaze Behavioural Brain Research 2001 125:261-267 DOI:10.1016/s0166-4328(01)00295-9 PMID:11682117
chapter
- Contet, C., Goulding, S. P., Kuljis, D. A., Barth, A. L. BK channels in the central nervous system Big on BK: Current insights into the function of large conductance voltage- and Ca2+-activated K+ channels at the molecular, cellular, and systemic levels. 281-342. 2016 DOI:10.1016/bs.irn.2016.04.001 PMID:27238267 PMCID:PMC4902275
- Contet, C. Big on BK: Current insights into the function of large conductance voltage- and Ca2+-activated K+ channels at the molecular, cellular, and systemic levels [Preface] Big on BK: Current insights into the function of large conductance voltage- and Ca2+-activated K+ channels at the molecular, cellular, and systemic levels. xiii-xiv. 2016
thesis
- Récepteurs aux opioïdes: adaptation moléculaires et comportementales à la morphine et souris génétiquement modifiées [Opioid receptors: molecular and behavioral adaptation to morphine and genetically modified mice] 2006

editor of

edited book
- Contet, C., Goulding, S. P., Kuljis, D. A., Barth, A. L., eds. Big on BK: Current insights into the function of large conductance voltage- and Ca2+-activated K+ channels at the molecular, cellular, and systemic levels International Review of Neurobiology. 2016

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