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Cognetta III, Armand B
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Cognetta III, Armand B

Graduate Student
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    • degree-related publication Pentinmikko, N., Iqbal, S., Mana, M., Andersson, S., Cognetta III, A. B., Suciu, R. M., Roper, J., Luopajarvi, K., Markelin, E., Gopalakrishnan, S., Smolander, O. P., Naranjo, S., et al. Notum produced by Paneth cells attenuates regeneration of aged intestinal epithelium Nature  2019 571:398-402  DOI:10.1038/s41586-019-1383-0  PMID:31292548
    • degree-related publication Chen, A. L., Lum, K. M., Lara-Gonzalez, P., Ogasawara, D., Cognetta III, A. B., To, A., Parsons, W. H., Simon, G. M., Desai, A., Petrascheck, M., Bar-Peled, L., Cravatt, B. F. Pharmacological convergence reveals a lipid pathway that regulates C. elegans lifespan Nature Chemical Biology  2019 15:453-462  DOI:10.1038/s41589-019-0243-4  PMID:30911178  PMCID:PMC6548519
    • degree-related publication Huang, Z.*, Ogasawara, D.*, Seneviratne, U. I., Cognetta III, A. B., Ende, C. W. A., Nason, D. M., Lapham, K., Litchfield, J., Johnson, D. S., Cravatt, B. F. Global portrait of protein targets of metabolites of the neurotoxic compound BIA 10-2474 ACS Chemical Biology  2019 14:192-197  DOI:10.1021/acschembio.8b01097  PMID:30702848  PMCID:PMC6383364 (* = equal contribution)
    • degree-related publication Suciu, R. M., Cognetta, A. B., Potter, Z. E., Cravatt, B. F. Selective irreversible inhibitors of the Wnt-deacylating enzyme NOTUM developed by activity-based protein profiling ACS Medicinal Chemistry Letters  2018 9:563-568  DOI:10.1021/acsmedchemlett.8b00191  PMID:29937983  PMCID:PMC6004566
    • degree-related publication Tan, J., Cognetta III, A. B., Diaz, D. B., Lum, K. M., Adachi, S., Kundu, S., Cravatt, B. F., Yudin, A. K. Multicomponent mapping of boron chemotypes furnishes selective enzyme inhibitors Nature Communications  2017 8  DOI:10.1038/s41467-017-01319-4  PMID:29170371  PMCID:PMC5701053
    • degree-related publication van Esbroeck, A. C. M., Janssen, A. P. A., Cognetta III, A. B., Ogasawara, D., Shpak, G., van der Kroeg, M., Kantae, V., Baggelaar, M. P., de Vrij, F. M. S., Deng, H., Allara, M., Fezza, F., et al. Activity-based protein profiling reveals off-target proteins of the FAAH inhibitor BIA 10-2474 Science  2017 356:1084-1087  DOI:10.1126/science.aaf7497  PMID:28596366  PMCID:PMC5641481
    • degree-related publication Kornahrens, A. F., Cognetta III, A. B., Brody, D. M., Matthews, M. L., Cravatt, B. F., Boger, D. L. Design of benzoxathiazin-3-one 1,1-dioxides as a new class of irreversible serine hydrolase inhibitors: Discovery of a uniquely selective PNPLA4 inhibitor Journal of the American Chemical Society  2017 139:7052-7061  DOI:10.1021/jacs.7602985  PMID:28498651
    • degree-related publication Touchette, M. H., Van Vlack, E. R., Bai, L., Kim, J., Cognetta III, A. B., Previti, M. L., Backus, K. M., Martin, D. W., Cravatt, B. F., Seeliger, J. C. A screen for protein-protein interactions in live mycobacteria reveals a functional link between the virulence-associated lipid transporter LprG and the mycolyltransferase antigen 85A ACS Infectious Diseases  2017 3:336-348  DOI:10.1021/acsinfecdis.6b00179  PMID:28276676
    • degree-related publication Parsons, W. H., Kolar, M. J., Kamat, S. S., Cognetta III, A. B., Hulce, J. J., Saez, E., Kahn, B. B., Saghatelian, A., Cravatt, B. F. AIG1 and ADTRP are atypical integral membrane hydrolases that degrade bioactive FAHFAs Nature Chemical Biology  2016 12:367-372  DOI:10.1038/nchembio.2051  PMID:27018888  PMCID:PMC4837090
    • degree-related publication Niphakis, M. J., Lum, K. M., Cognetta III, A. B., Correia, B. E., Ichu, T. A., Olucha, J., Brown, S. J., Kundu, S., Piscitelli, F., Rosen, H., Cravatt, B. F. A global map of lipid-binding proteins and their ligandability in cells Cell  2015 161:1668-1680  DOI:10.1016/j.cell.2015.05.045  PMID:26091042  PMCID:PMC4615699
    • degree-related publication Adachi, S., Cognetta III, A. B., Niphakis, M. J., He, Z., Zajdlik, A., St. Denis, J. D., Scully, C. C. G., Cravatt, B. F., Yudin, A. K. Facile synthesis of borofragments and their evaluation in activity-based protein profiling Chemical Communications  2015 51:3608-3611  DOI:10.1039/c4cc09107h  PMID:25633248  PMCID:PMC4330092
    • degree-related publication Cognetta III, A. B., Niphakis, M. J., Lee, H. C., Martini, M. L., Hulce, J. J., Cravatt, B. F. Selective N-hydroxyhydantoin carbamate inhibitors of mammalian serine hydrolases Chemistry & Biology  2015 22:928-937  DOI:10.1016/j.chembiol.2015.05.018  PMID:26120000  PMCID:PMC4527528
    • degree-related publication Lajkiewicz, N. J., Cognetta III, A. B., Niphakis, M. J., Cravatt, B. F., Porco Jr., J. A. Remodeling natural products: chemistry and serine hydrolase activity of a rocaglate-derived beta-lactone Journal of the American Chemical Society  2014 136:2659-2664  DOI:10.1021/ja412431g  PMID:24447064  PMCID:PMC3978386
    • Niphakis, M. J., Cognetta III, A. B., Chang, J. W., Buczynski, M. W., Parsons, L. H., Byrne, F., Burston, J. J., Chapman, V., Cravatt, B. F. Evaluation of NHS carbamates as a potent and selective class of endocannabinoid hydrolase inhibitors ACS Chemical Neuroscience  2013 4:1322-1332  DOI:10.1021/cn400116z  PMID:23731016  PMCID:PMC3778430
    • Chang, J. W., Cognetta III, A. B., Niphakis, M. J., Cravatt, B. F. Proteome-wide reactivity profiling identifies diverse carbamate chemotypes tuned for serine hydrolase inhibition ACS Chemical Biology  2013 8:1590-1599  DOI:10.1021/cb400261h  PMID:23701408  PMCID:PMC3806897
    • Hulce, J. J., Cognetta III, A. B., Niphakis, M. J., Tully, S. E., Cravatt, B. F. Proteome-wide mapping of cholesterol-interacting proteins in mammalian cells Nature Methods  2013 10:259-264  DOI:10.1038/nmeth.2368  PMID:23396283  PMCID:PMC3601559
    • Chang, J. W., Niphakis, M. J., Lum, K. M., Cognetta III, A. B., Wang, C., Matthews, M. L., Niessen, S., Buczynski, M. W., Parsons, L. H., Cravatt, B. F. Highly selective inhibitors of monoacylglycerol lipase bearing a reactive group that is bioisosteric with endocannabinoid substrates Chemistry & Biology  2012 19:579-588  DOI:10.1016/j.chembiol.2012.03.009  PMID:22542104  PMCID:PMC3361572
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Background

education and training

  • Ph.D. in Chemical Biology, Scripps Research 2013 - 2018
  • B.S. in Biochemistry, University of Virginia 2008 - 2011

advisee of

  • graduate advising relationship

    • Cravatt, Benjamin, Ph.D.  candidacy, 2014 - 2018
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Contact

full name

  • Armand B Cognetta III

geographic location

  • Scripps California 
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Identity

ORCID iD

  • ORCID iD http://orcid.org/0000-0003-0773-0674

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