recent publications
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academic article
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Pentinmikko, N., Iqbal, S., Mana, M., Andersson, S., Cognetta III, A. B., Suciu, R. M., Roper, J., Luopajarvi, K., Markelin, E., Gopalakrishnan, S., Smolander, O. P., Naranjo, S., et al. Notum produced by Paneth cells attenuates regeneration of aged intestinal epithelium Nature 2019 571:398-402 DOI:10.1038/s41586-019-1383-0 PMID:31292548
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Chen, A. L., Lum, K. M., Lara-Gonzalez, P., Ogasawara, D., Cognetta III, A. B., To, A., Parsons, W. H., Simon, G. M., Desai, A., Petrascheck, M., Bar-Peled, L., Cravatt, B. F. Pharmacological convergence reveals a lipid pathway that regulates C. elegans lifespan Nature Chemical Biology 2019 15:453-462 DOI:10.1038/s41589-019-0243-4 PMID:30911178 PMCID:PMC6548519
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Huang, Z.*, Ogasawara, D.*, Seneviratne, U. I., Cognetta III, A. B., Ende, C. W. A., Nason, D. M., Lapham, K., Litchfield, J., Johnson, D. S., Cravatt, B. F. Global portrait of protein targets of metabolites of the neurotoxic compound BIA 10-2474 ACS Chemical Biology 2019 14:192-197 DOI:10.1021/acschembio.8b01097 PMID:30702848 PMCID:PMC6383364 (* = equal contribution)
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Suciu, R. M., Cognetta, A. B., Potter, Z. E., Cravatt, B. F. Selective irreversible inhibitors of the Wnt-deacylating enzyme NOTUM developed by activity-based protein profiling ACS Medicinal Chemistry Letters 2018 9:563-568 DOI:10.1021/acsmedchemlett.8b00191 PMID:29937983 PMCID:PMC6004566
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Tan, J., Cognetta III, A. B., Diaz, D. B., Lum, K. M., Adachi, S., Kundu, S., Cravatt, B. F., Yudin, A. K. Multicomponent mapping of boron chemotypes furnishes selective enzyme inhibitors Nature Communications 2017 8 DOI:10.1038/s41467-017-01319-4 PMID:29170371 PMCID:PMC5701053
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van Esbroeck, A. C. M., Janssen, A. P. A., Cognetta III, A. B., Ogasawara, D., Shpak, G., van der Kroeg, M., Kantae, V., Baggelaar, M. P., de Vrij, F. M. S., Deng, H., Allara, M., Fezza, F., et al. Activity-based protein profiling reveals off-target proteins of the FAAH inhibitor BIA 10-2474 Science 2017 356:1084-1087 DOI:10.1126/science.aaf7497 PMID:28596366 PMCID:PMC5641481
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Kornahrens, A. F., Cognetta III, A. B., Brody, D. M., Matthews, M. L., Cravatt, B. F., Boger, D. L. Design of benzoxathiazin-3-one 1,1-dioxides as a new class of irreversible serine hydrolase inhibitors: Discovery of a uniquely selective PNPLA4 inhibitor Journal of the American Chemical Society 2017 139:7052-7061 DOI:10.1021/jacs.7602985 PMID:28498651
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Touchette, M. H., Van Vlack, E. R., Bai, L., Kim, J., Cognetta III, A. B., Previti, M. L., Backus, K. M., Martin, D. W., Cravatt, B. F., Seeliger, J. C. A screen for protein-protein interactions in live mycobacteria reveals a functional link between the virulence-associated lipid transporter LprG and the mycolyltransferase antigen 85A ACS Infectious Diseases 2017 3:336-348 DOI:10.1021/acsinfecdis.6b00179 PMID:28276676
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Parsons, W. H., Kolar, M. J., Kamat, S. S., Cognetta III, A. B., Hulce, J. J., Saez, E., Kahn, B. B., Saghatelian, A., Cravatt, B. F. AIG1 and ADTRP are atypical integral membrane hydrolases that degrade bioactive FAHFAs Nature Chemical Biology 2016 12:367-372 DOI:10.1038/nchembio.2051 PMID:27018888 PMCID:PMC4837090
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Niphakis, M. J., Lum, K. M., Cognetta III, A. B., Correia, B. E., Ichu, T. A., Olucha, J., Brown, S. J., Kundu, S., Piscitelli, F., Rosen, H., Cravatt, B. F. A global map of lipid-binding proteins and their ligandability in cells Cell 2015 161:1668-1680 DOI:10.1016/j.cell.2015.05.045 PMID:26091042 PMCID:PMC4615699
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Adachi, S., Cognetta III, A. B., Niphakis, M. J., He, Z., Zajdlik, A., St. Denis, J. D., Scully, C. C. G., Cravatt, B. F., Yudin, A. K. Facile synthesis of borofragments and their evaluation in activity-based protein profiling Chemical Communications 2015 51:3608-3611 DOI:10.1039/c4cc09107h PMID:25633248 PMCID:PMC4330092
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Cognetta III, A. B., Niphakis, M. J., Lee, H. C., Martini, M. L., Hulce, J. J., Cravatt, B. F. Selective N-hydroxyhydantoin carbamate inhibitors of mammalian serine hydrolases Chemistry & Biology 2015 22:928-937 DOI:10.1016/j.chembiol.2015.05.018 PMID:26120000 PMCID:PMC4527528
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Lajkiewicz, N. J., Cognetta III, A. B., Niphakis, M. J., Cravatt, B. F., Porco Jr., J. A. Remodeling natural products: chemistry and serine hydrolase activity of a rocaglate-derived beta-lactone Journal of the American Chemical Society 2014 136:2659-2664 DOI:10.1021/ja412431g PMID:24447064 PMCID:PMC3978386
- Niphakis, M. J., Cognetta III, A. B., Chang, J. W., Buczynski, M. W., Parsons, L. H., Byrne, F., Burston, J. J., Chapman, V., Cravatt, B. F. Evaluation of NHS carbamates as a potent and selective class of endocannabinoid hydrolase inhibitors ACS Chemical Neuroscience 2013 4:1322-1332 DOI:10.1021/cn400116z PMID:23731016 PMCID:PMC3778430
- Chang, J. W., Cognetta III, A. B., Niphakis, M. J., Cravatt, B. F. Proteome-wide reactivity profiling identifies diverse carbamate chemotypes tuned for serine hydrolase inhibition ACS Chemical Biology 2013 8:1590-1599 DOI:10.1021/cb400261h PMID:23701408 PMCID:PMC3806897
- Hulce, J. J., Cognetta III, A. B., Niphakis, M. J., Tully, S. E., Cravatt, B. F. Proteome-wide mapping of cholesterol-interacting proteins in mammalian cells Nature Methods 2013 10:259-264 DOI:10.1038/nmeth.2368 PMID:23396283 PMCID:PMC3601559
- Chang, J. W., Niphakis, M. J., Lum, K. M., Cognetta III, A. B., Wang, C., Matthews, M. L., Niessen, S., Buczynski, M. W., Parsons, L. H., Cravatt, B. F. Highly selective inhibitors of monoacylglycerol lipase bearing a reactive group that is bioisosteric with endocannabinoid substrates Chemistry & Biology 2012 19:579-588 DOI:10.1016/j.chembiol.2012.03.009 PMID:22542104 PMCID:PMC3361572
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