Cleveland, John

Faculty Member

Positions

2006 - 2014 Chairman, Cancer Biology , Scripps Research
2006 - 2014 Professor, Cancer Biology , Scripps Research
2006 - 2014 Faculty Member, Skaggs Graduate School of Chemical and Biological Sciences , Scripps Research

Dr. John L. Cleveland studies the molecular basis of cancer with a focus on malignancies having myc involvement, which is activated in 70% of all human cancers. Target discovery validation using mouse models, and cancer prevention and therapeutics are the major focuses of the laboratory.

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recent publications

academic article
- Zahedi, K., Brooks, M., Barone, S., Rahmati, N., Stewart, T. M., Dunworth, M., Destefano-Shields, C., Dasgupta, N., Davidson, S., Lindquist, D. M., Fuller, C. E., Smith, R. D., et al. Ablation of polyamine catabolic enzymes provokes Purkinje cell damage, neuroinflammation, and severe ataxia Journal of Neuroinflammation 2020 17 DOI:10.1186/s12974-020-01955-6 PMID:33054763 PMCID:PMC7559641
- Kwong, T., Ma, M., Pan, G., Hindra, Yang, D., Yang, C., Lohman, J. R., Rudolf, J. D., Cleveland, J. L., Shen, B. P450-catalyzed tailoring steps in leinamycin biosynthesis featuring regio- and stereoselective hydroxylations and substrate promiscuities Biochemistry 2018 57:5005-5013 DOI:10.1021/acs.biochem.8b00623 PMID:30070831 PMCID:PMC6211295
- Getun, I. V., Wu, Z., Fallahi, M., Ouizem, S., Liu, Q., Li, W., Costi, R., Roush, W. R., Cleveland, J. L., Bois, P. R. J. Functional roles of acetylated histone marks at mouse meiotic recombination hot spots Molecular and Cellular Biology 2017 37:UNSP e00942-15 DOI:10.1128/mcb.00942-15 PMID:27821479 PMCID:PMC5247613
- Pan, X., Yang, C., Cleveland, J. L., Bannister, T. D. Synthesis and cytoxicity of sempervirine and analogues Journal of Organic Chemistry 2016 81:2194-2200 DOI:10.1021/acs.joc.6b00022 PMID:26828413
- Nair, R. N., Mishra, J. K., Li, F., Tortosa, M., Yang, C., Doherty, J. R., Cameron, M., Cleveland, J. L., Roush, W. R., Bannister, T. D. Exploiting the co-reliance of tumours upon transport of amino acids and lactate: Gln and Tyr conjugates of MCT1 inhibitors MedChemComm 2016 7:900-905 DOI:10.1039/c5md00579e PMID:27347360
- Rosenberg, L. H., Lafitte, M., Quereda, V., Grant, W., Chen, W., Bibian, M., Noguchi, Y., Fallahi, M., Yang, C., Chang, J. C., Roush, W. R., Cleveland, J. L., et al. Therapeutic targeting of casein kinase 1δ in breast cancer Science Translational Medicine 2015 7:318ra202 DOI:10.1126/scitranslmed.aac8773 PMID:26676609 PMCID:PMC4809734
- Schaub, F. X., Reza, M. S., Flaveny, C. A., Li, W., Musicant, A. M., Hoxha, S., Guo, M., Cleveland, J. L., Amelio, A. L. Fluorophore-NanoLuc BRET reporters enable sensitive in vivo optical imaging and flow cytometry for monitoring tumorigenesis Cancer Research 2015 75:5023-5033 DOI:10.1158/0008-5472.can-14-3538 PMID:26424696 PMCID:PMC4668208
- Liu, T., Ma, M., Ge, H. M., Yang, C., Cleveland, J., Shen, B. Synthesis and evaluation of 8,4 '-dideshydroxy-leinamycin revealing new insights into the structure-activity relationship of the anticancer natural product leinamycin Bioorganic & Medicinal Chemistry Letters 2015 25:4899-4902 DOI:10.1016/j.bmcl.2015.05.078 PMID:26071634 PMCID:PMC4607584
- Liu, T., Ma, M., Ge, H. M., Yang, C., Cleveland, J., Shen, B. Synthesis and evaluation of 8,4'-dideshydroxy-leinamycin revealing new insights into the structure-activity relationship of the anticancer natural product leinamycin Bioorganic & Medicinal Chemistry Letters 2015 DOI:10.1016/j.bmcl.2015.05.078 PMID:26071634 PMCID:PMC4607584
- Rosenberg, L. H., Lafitte, M., Grant, W., Chen, W., Cleveland, J. L., Duckett, D. R. Development of an HTS-compatible assay for the discovery of Ulk1 inhibitors Journal of Biomolecular Screening 2015 20:913-920 DOI:10.1177/1087057115579391 PMID:25851035 PMCID:PMC4744088
- Ghalei, H., Schaub, F. X., Doherty, J. R., Noguchi, Y., Roush, W. R., Cleveland, J. L., Stroupe, M. E., Karbstein, K. Hrr25/CK1 delta-directed release of Ltv1 from pre-40S ribosomes is necessary for ribosome assembly and cell growth Journal of Cell Biology 2015 208:745-759 DOI:10.1083/jcb.201409056 PMID:25778921 PMCID:PMC4362465
- Fallahi, M., Amelio, A. L., Cleveland, J. L., Rounbehler, R. J. CREB targets define the gene expression signature of malignancies having reduced levels of the tumor suppressor tristetraprolin PLoS One 2014 9:e115517 DOI:10.1371/journal.pone.0115517 PMID:25541715 PMCID:PMC4277357
- Seo, J. W., Ma, M., Kwong, T., Ju, J., Lim, S. K., Jiang, H., Lohman, J. R., Yang, C., Cleveland, J., Zazopoulos, E., Farnet, C. M., Shen, B. Comparative characterization of the lactimidomycin and iso-migrastatin biosynthetic machineries revealing unusual features for acyltransferase-less type I polyketide synthases and providing an opportunity to engineer new analogues Biochemistry 2014 53:7854-7865 DOI:10.1021/bi501396v PMID:25405956 PMCID:PMC4270375
- Hoellein, A., Fallahi, M., Schoeffmann, S., Steidle, S., Schaub, F. X., Rudelius, M., Laitinen, I., Nilsson, L., Goga, A., Peschel, C., Nilsson, J. A., Cleveland, J. L., et al. Myc-induced SUMOylation is a therapeutic vulnerability for B-cell lymphoma Blood 2014 124:2081-2090 DOI:10.1182/blood-2014-06-584524 PMID:25143484 PMCID:PMC4186537
- Wang, H., Yang, C., Doherty, J. R., Roush, W. R., Cleveland, J. L., Bannister, T. D. Synthesis and structure-activity relationships of pteridine dione and trione monocarboxylate transporter 1 inhibitors Journal of Medicinal Chemistry 2014 57:7317-7324 DOI:10.1021/jm500640x PMID:25068893 PMCID:PMC4161152
- Amelio, A. L., Fallahi, M., Schaub, F. X., Zhang, M., Lawani, M. B., Alperstein, A. S., Southern, M. R., Young, B. M., Wu, L., Zajac-Kaye, M., Kaye, F. J., Cleveland, J. L., et al. CRTC1/MAML2 gain-of-function interactions with MYC create a gene signature predictive of cancers with CREB-MYC involvement Proceedings of the National Academy of Sciences of the United States of America 2014 111:E3260-E3268 DOI:10.1073/pnas.1319176111 PMID:25071166 PMCID:PMC4136562
- Lu, Y., Wu, Y., Feng, X., Shen, R., Wang, J. H., Fallahi, M., Li, W., Yang, C., Hankey, W., Zhao, W., Ganju, R. K., Li, M. O., et al. CDK4 deficiency promotes genomic instability and enhances Myc-driven lymphomagenesis Journal of Clinical Investigation 2014 124:1672-1684 DOI:10.1172/jci63139 PMID:24614102 PMCID:PMC3973114
- Doherty, J. R., Yang, C., Scott, K. E. N., Cameron, M. D., Fallahi, M., Li, W., Hall, M. A., Amelio, A. L., Mishra, J. K., Li, F., Tortosa, M., Genau, H. M., et al. Blocking lactate export by inhibiting the Myc target MCT1 disables glycolysis and glutathione synthesis Cancer Research 2014 74:908-920 DOI:10.1158/0008-5472.can-13-2034 PMID:24285728 PMCID:PMC3946415
- Canterbury, D. P., Scott, K. E. N., Kubo, O., Jansen, R., Cleveland, J. L., Micalizio, G. C. Synthesis of C11-desmethoxy soraphen A(1 alpha): a natural product analogue that inhibits acetyl-CoA carboxylase ACS Medicinal Chemistry Letters 2013 4:1244-1248 DOI:10.1021/ml400377p PMID:24639892 PMCID:PMC3951358
- Doherty, J. R., Cleveland, J. L. Targeting lactate metabolism for cancer therapeutics Journal of Clinical Investigation 2013 123:3685-3692 DOI:10.1172/jci69741 PMID:23999443 PMCID:PMC3754272
- Bibian, M., Rahaim, R. J., Choi, J. Y., Noguchi, Y., Schurer, S., Chen, W. M., Nakanishi, S., Licht, K., Rosenberg, L. H., Li, L., Feng, Y., Cameron, M. D., et al. Development of highly selective casein kinase 1δ/1ε (CK1δ/ε) inhibitors with potent antiproliferative properties Bioorganic & Medicinal Chemistry Letters 2013 23:4374-4380 DOI:10.1016/j.bmcl.2013.05.075 PMID:23787102 PMCID:PMC3783656
- Jeso, V., Yang, C., Cameron, M. D., Cleveland, J. L., Micalizio, G. C. Synthesis and SAR of lehualide B: A marine-derived natural product with potent anti-multiple myeloma activity ACS Chemical Biology 2013 8:1241-1252 DOI:10.1021/cb300582s PMID:23547759 PMCID:PMC3758376
- Rounbehler, R. J., Fallahi, M., Yang, C. Y., Steeves, M. A., Li, W. M., Doherty, J. R., Schaub, F. X., Sanduja, S., Dixon, D. A., Blackshear, P. J., Cleveland, J. L. Tristetraprolin impairs myc-induced lymphoma and abolishes the malignant state Cell 2012 150:563-574 DOI:10.1016/j.cell.2012.06.033 PMID:22863009 PMCID:PMC3422762
- Valentin-Vega, Y. A., MacLean, K. H., Tait-Mulder, J., Milasta, S., Steeves, M., Dorsey, F. C., Cleveland, J. L., Green, D. R., Kastan, M. B. Mitochondrial dysfunction in ataxia-telangiectasia Blood 2012 119:1490-1500 DOI:10.1182/blood-2011-08-373639 PMID:22144182 PMCID:PMC3286212
- Ji, H. K., Wu, G., Zhan, X. C., Nolan, A., Koh, C., De Marzo, A., Doan, H. M., Fan, J. S., Cheadle, C., Fallahi, M., Cleveland, J. L., Dang, C. V., et al. Cell-type independent myc target genes reveal a primordial signature involved in biomass accumulation PLoS One 2011 6:e26057 DOI:10.1371/journal.pone.0026057 PMID:22039435 PMCID:PMC3198433
- Joo, J. H., Dorsey, F. C., Joshi, A., Hennessy-Walters, K. M., Rose, K. L., McCastlain, K., Zhang, J., Iyengar, R., Jung, C. H., Suen, D. F., Steeves, M. A., Yang, C. Y., et al. Hsp90-cdc37 chaperone complex regulates ulk1-and atg13-mediated mitophagy Molecular Cell 2011 43:572-585 DOI:10.1016/j.molcel.2011.06.018 PMID:21855797 PMCID:PMC3485687
- Ouellette, S. P., Dorsey, F. C., Moshiach, S., Cleveland, J. L., Carabeo, R. A. Chlamydia species-dependent differences in the growth requirement for lysosomes PLoS One 2011 6:e16783 DOI:10.1371/journal.pone.0016783 PMID:21408144 PMCID:PMC3050816
- den Hollander, J., Rimpi, S., Doherty, J. R., Rudelius, M., Buck, A., Hoellein, A., Kremer, M., Graf, N., Scheerer, M., Hall, M. A., Goga, A., von Bubnoff, N., et al. Aurora kinases a and b are up-regulated by myc and are essential for maintenance of the malignant state Blood 2010 116:1498-1505 DOI:10.1182/blood-2009-11-251074 PMID:20519624 PMCID:PMC2938839
- Keller, U., Huber, J., Nilsson, J. A., Fallahi, M., Hall, M. A., Peschel, C., Cleveland, J. L. Myc suppression of nfkb2 accelerates lymphomagenesis BMC Cancer 2010 10:348 DOI:10.1186/1471-2407-10-348 PMID:20598117 PMCID:PMC2902445
- Rethman, M. P., Carpenter, W., Cohen, E. E. W., Epstein, J., Evans, C. A., Flaitz, C. M., Graham, F. J., Hujoel, P. P., Kalmar, J. R., Koch, W. M., Lambert, P. M., Lingen, M. W., et al. Evidence-based clinical recommendations regarding screening for oral squamous cell carcinomas Journal of the American Dental Association 2010 141:509-520 PMID:20436098
- Steeves, M. A., Dorsey, F. C., Cleveland, J. L. Targeting the autophagy pathway for cancer chemoprevention Current Opinion in Cell Biology 2010 22:218-225 DOI:10.1016/j.ceb.2009.12.013 PMID:20096553 PMCID:PMC2854265
- Old, J. B., Kratzat, S., Hoellein, A., Graf, S., Nilsson, J. A., Nilsson, L., Nakayama, K. I., Peschel, C., Cleveland, J. L., Keller, U. B. Skp2 directs myc-mediated suppression of p27(kip1) yet has modest effects on myc-driven lymphomagenesis Molecular Cancer Research 2010 8:353-362 DOI:10.1158/1541-7786.mcr-09-0232 PMID:20197382 PMCID:PMC3095030
- Dorsey, F. C., Rose, K. L., Coenen, S., Prater, S. M., Cavett, V., Cleveland, J. L., Caldwell-Busby, J. Mapping the phosphorylation sites of ulk1 Journal of Proteome Research 2009 8:5253-5263 DOI:10.1021/pr900583m PMID:19807128
- Zhang, J., Randall, M. S., Loyd, M. R., Dorsey, F. C., Kundu, M., Cleveland, J. L., Ney, P. A. Mitochondrial clearance is regulated by atg7-dependent and -independent mechanisms during reticulocyte maturation Blood 2009 114:157-164 DOI:10.1182/blood-2008-04-151639 PMID:19417210 PMCID:PMC2710944
- Rounbehler, R. J., Li, W. M., Hall, M. A., Yang, C. Y., Fallahi, M., Cleveland, J. L. Targeting ornithine decarboxylase impairs development of mycn-amplified neuroblastoma Cancer Research 2009 69:547-553 DOI:10.1158/0008-5472.can-08-2968 PMID:19147568 PMCID:PMC2749594
- Nawrocki, S. T., Carew, J. S., Maclean, K. H., Courage, J. F., Huang, P., Houghton, J. A., Cleveland, J. L., Giles, F. J., McConkey, D. J. Myc regulates aggresome formation, the induction of noxa, and apoptosis in response to the combination of bortezomib and saha Blood 2008 112:2917-2926 DOI:10.1182/blood-2007-12-130823 PMID:18641367 PMCID:PMC2556625
- Garrison, S. P., Jeffers, J. R., Yang, C. Y., Nilsson, J. A., Hall, M. A., Rehg, J. E., Yue, W., Yu, J., Zhang, L., Onciu, M., Sample, J. T., Cleveland, J. L., et al. Selection against puma gene expression in myc-driven b-cell lymphomagenesis Molecular and Cellular Biology 2008 28:5391-5402 DOI:10.1128/mcb.00907-07 PMID:18573879 PMCID:PMC2519737
- Carew, J. S., Nawrocki, S. T., Reddy, V. A., Bush, D., Rehg, J. E., Goodwin, A., Houghton, J. A., Casero, R. A., Marton, L. J., Cleveland, J. L. The novel polyamine analogue CGC-11093 enhances the antimyeloma activity of bortezomib Cancer Research 2008 68:4783-4790 DOI:10.1158/0008-5472.can-07-6483 PMID:18559525 PMCID:PMC2749595
- Rodrigues, C. O., Nerlick, S. T., White, E. L., Cleveland, J. L., King, M. L. A myc-slug (snail2)/twist regulatory circuit directs vascular development Development 2008 135:1903-1911 DOI:10.1242/dev.011296 PMID:18469221 PMCID:PMC2741485
- Klionsky, D. J., Abeliovich, H., Agostinis, P., Agrawal, D. K., Aliev, G., Askew, D. S., Baba, M., Baehrecke, E. H., Bahr, B. A., Ballabio, A., Bamber, B. A., Bassham, D. C., et al. Guidelines for the use and interpretation of assays for monitoring autophagy in higher eukaryotes Autophagy 2008 4:151-175 PMID:18188003 PMCID:PMC2654259
- Maclean, K. H., Dorsey, F. C., Cleveland, J. L., Kastan, M. B. Targeting lysosomal degradation induces p53-dependent cell death and prevents cancer in mouse models of lymphomagenesis Journal of Clinical Investigation 2008 118:79-88 DOI:10.1172/jci33700 PMID:18097482 PMCID:PMC2148253
- Sanjuan, M. A., Dillon, C. P., Tait, S. W. G., Moshiach, S., Dorsey, F., Connell, S., Komatsu, M., Tanaka, K., Cleveland, J. L., Withoff, S., Green, D. R. Toll-like receptor signalling in macrophages links the autophagy pathway to phagocytosis Nature 2007 450:1253-1257 DOI:10.1038/nature06421 PMID:18097414
- Schweers, R. L., Zhang, J., Randall, M. S., Loyd, M. R., Li, W., Dorsey, F. C., Kundu, M., Opferman, J. T., Cleveland, J. L., Miller, J. L., Ney, P. A. Nix is required for programmed mitochondrial clearance during reticulocyte maturation Proceedings of the National Academy of Sciences of the United States of America 2007 104:19500-19505 DOI:10.1073/pnas.0708818104 PMID:18048346 PMCID:PMC2148318
- Carew, J. S., Nawrocki, S. T., Cleveland, J. L. Modulating autophagy for therapeutic benefit Autophagy 2007 3:464-467 PMID:17495516
- Nawrocki, S. T., Carew, J. S., Donglas, L., Cleveland, J. L., Humphreys, R., Houghton, J. A. Histone deacetylase inhibitors enhance lexaturnurnab-induced apoptosis via a p21(cip1)-dependent decrease in survivin levels Cancer Research 2007 67:6987-6994 DOI:10.1158/0008-5472.can-07-0812 PMID:17638911
- Maclean, K. H., Kastan, M. B., Cleveland, J. L. Atm deficiency affects both apoptosis and proliferation to augment myc-induced lymphomagenesis Molecular Cancer Research 2007 5:705-711 DOI:10.1158/1541-7786.mcr-07-0058 PMID:17634425
- Carew, J. S., Nawrocki, S. T., Kahue, C. N., Zhang, H., Yang, C. Y., Chung, L., Houghton, J. A., Huang, P., Giles, F. J., Cleveland, J. L. Targeting autophagy augments the anticancer activity of the histone deacetylase inhibitor saha to overcome bcr-abl-mediated drug resistance Blood 2007 110:313-322 DOI:10.1182/blood-2006-10-050260 PMID:17363733 PMCID:PMC1896119
- Keller, U. B., Old, J. B., Dorsey, F. C., Nilsson, J. A., Nilsson, L., MacLean, K. H., Chung, L., Yang, C. Y., Spruck, C., Boyd, K., Reed, S. I., Cleveland, J. L. Myc targets cks1 to provoke the suppression of p27(kip1), proliferation and lymphomagenesis EMBO Journal 2007 26:2562-2574 DOI:10.1038/sj.emboj.7601691 PMID:17464290 PMCID:PMC1868903
- Nilsson, L. M., Keller, U. B., Yang, C., Nilsson, J. A., Cleveland, J. L., Roussel, M. F. Ink4c is dispensable for tumor suppression in myc-induced b-cell lymphomagenesis Oncogene 2007 26:2833-2839 DOI:10.1038/sj.onc.1210104 PMID:17099725
- Wen, R. R., Chen, Y. H., Bai, L., Fu, G. P., Schuman, J., Dai, X. Z., Zeng, H., Yang, C. Y., Stephan, R. P., Cleveland, J. L., Wang, D. M. Essential role of phospholipase c gamma 2 in early b-cell development and myc-mediated lymphomagenesis Molecular and Cellular Biology 2006 26:9364-9376 DOI:10.1128/mcb.00839-06 PMID:17030619
- Moreno-Miralles, I., Pan, L., Keates-Baleeiro, J., Durst-Goodwin, K., Yang, C. Y., Kim, H. G., Thompson, M. A., Klug, C. A., Cleveland, J. L., Hiebert, S. W. The inv(16) cooperates with arf haploinsufficiency to induce acute myeloid leukemia Journal of Biological Chemistry 2005 280:40097-40103 DOI:10.1074/jbc.M506855200 PMID:16199529
- Kasper, L. H., Boussouar, F., Boyd, K., Xu, W., Biesen, M., Rehg, J., Baudino, T. A., Cleveland, J. L., Brindle, P. K. Two transactivation mechanisms cooperate for the bulk of hif-1-responsive gene expression EMBO Journal 2005 24:3846-3858 DOI:10.1038/sj.emboj.7600846 PMID:16237459 PMCID:PMC1283945
- Bois, P. R. J., Brochard, V. F., Salin-Cantegrel, A. V. A., Cleveland, J. L., Grosveld, G. C. Foxo1a-cyclic gmp-dependent kinase i interactions orchestrate myoblast fusion Molecular and Cellular Biology 2005 25:7645-7656 DOI:10.1128/mcb.25.17.7645-7656.2005 PMID:16107711
- Keller, U., Nilsson, J. A., Maclean, K. H., Old, J. B., Cleveland, J. L. Nfkb1 is dispensable for myc-induced lymphomagenesis Oncogene 2005 24:6231-6240 DOI:10.1038/sj.onc.1208779 PMID:15940251
- Ulett, G. C., Maclean, K. H., Nekkalapu, S., Cleveland, J. L., Adderson, E. E. Mechanisms of group b streptococcal-induced apoptosis of murine macrophages Journal of Immunology 2005 175:2555-2562 PMID:16081829
- Hemann, M. T., Bric, A., Teruya-Feldstein, J., Herbst, A., Nilsson, J. A., Cordon-Cardo, C., Cleveland, J. L., Tansey, W. P., Lowe, S. W. Evasion of the p53 tumour surveillance network by tumour-derived myc mutants Nature 2005 436:807-811 DOI:10.1038/nature03845 PMID:16094360 PMCID:PMC4599579
- Nilsson, J. A., Keller, U. B., Baudino, T. A., Yang, C. Y., Norton, S., Old, J. A., Nilsson, L. M., Neale, G., Kramer, D. L., Porter, C. W., Cleveland, J. L. Targeting ornithine decarboxylase in myc-induced lymphomagenesis prevents tumor formation Cancer Cell 2005 7:433-444 DOI:10.1016/j.ccr.2005.03.036 PMID:15894264
- Cardone, M., Kandilci, A., Carella, C., Nilsson, J. A., Brennan, J. A., Sirma, S., Ozbek, U., Boyd, K., Cleveland, J. L., Grosveld, G. C. The novel ets factor tel2 cooperates with myc in b lymphomagenesis Molecular and Cellular Biology 2005 25:2395-2405 DOI:10.1128/mcb.25.6.2395-2405.2005 PMID:15743832
- Guo, Y. J., Cleveland, J. L., O'Brien, T. G. Haploinsufficiency for odc modifies mouse skin tumor susceptibility Cancer Research 2005 65:1146-1149 DOI:10.1158/0008-5472.can-04-3244 PMID:15734996
- Nilsson, J. A., Nilsson, L. M., Keller, U., Yokota, Y., Boyd, K., Cleveland, J. L. Id2 is dispensable for myc-induced lymphomagenesis Cancer Research 2004 64:7296-7301 DOI:10.1158/0008-5472.can-04-2133 PMID:15492249
- Nilsson, J. A., Cleveland, J. L. Mnt: Master regulator of the max network Cell Cycle 2004 3:588-590 PMID:15107624
- Nilsson, J. A., Maclean, K. H., Keller, U. B., Pendeville, H., Baudino, T. A., Cleveland, J. L. Mnt loss triggers myc transcription targets, proliferation, apoptosis, and transformation Molecular and Cellular Biology 2004 24:1560-1569 DOI:10.1128/mcb.24.4.1560-1569.2004 PMID:14749372
- Zindy, F., Williams, R. T., Baudino, T. A., Rehg, J. E., Skapek, S. X., Cleveland, J. L., Roussel, M. F., Sherr, C. J. Arf tumor suppressor promoter monitors latent oncogenic signals in vivo Proceedings of the National Academy of Sciences of the United States of America 2003 100:15930-15935 DOI:10.1073/pnas.02536808100 PMID:14665695
- Nilsson, J. A., Cleveland, J. L. Myc pathways provoking cell suicide and cancer Oncogene 2003 22:9007-9021 DOI:10.1038/sj.onc.1207261 PMID:14663479
- Maclean, K. H., Keller, U. B., Rodriguez-Galindo, C., Nilsson, J. A., Cleveland, J. L. C-myc augments gamma irradiation-induced apoptosis by suppressing bcl-x-l Molecular and Cellular Biology 2003 23:7256-7270 DOI:10.1128/mcb.23.20.7256-7270.2003 PMID:14517295
- Jeffers, J. R., Parganas, E., Lee, Y., Yang, C. Y., Wang, J. L., Brennan, J., MacLean, K. H., Han, J. W., Chittenden, T., Ihle, J. N., McKinnon, P. J., Cleveland, J. L., et al. Puma is an essential mediator of p53-dependent and -independent apoptotic pathways Cancer Cell 2003 4:321-328 DOI:10.1016/s1535-6108(03)00244-7 PMID:14585359
- Baudino, T. A., Maclean, K. H., Brennan, J., Parganas, E., Yang, C. Y., Aslanian, A., Lees, J. A., Sherr, C. J., Roussel, M. F., Cleveland, J. L. Myc-mediated proliferation and lymphomagenesis, but not apoptosis, are compromised by e2f1 loss Molecular Cell 2003 11:905-914 DOI:10.1016/s1097-2765(03)00102-3 PMID:12718877
- Alt, J. R., Greiner, T. C., Cleveland, J. L., Eischen, C. M. Mdm2 haplo-insufficiency profoundly inhibits myc-induced lymphomagenesis EMBO Journal 2003 22:1442-1450 DOI:10.1093/emboj/cdg133 PMID:12628936 PMCID:PMC151074
- Baudino, T. A., McKay, C., Pendeville-Samain, H., Nilsson, J. A., Maclean, K. H., White, E. L., Davis, A. C., Ihle, J. N., Cleveland, J. L. C-myc is essential for vasculogenesis and angiogenesis during development and tumor progression Genes & Development 2002 16:2530-2543 DOI:10.1101/gad.1024602 PMID:12368264 PMCID:PMC187450
- Linggi, B., Muller-Tidow, C., van de Locht, L., Hu, M., Nip, J., Serve, H., Berdel, W. E., van der Reijden, B., Quelle, D. E., Rowley, J. D., Cleveland, J., Jansen, J. H., et al. The t(8;21) fusion protein, aml1-eto, specifically represses the transcription of the p14(arf) tumor suppressor in acute myeloid leukemia Nature Medicine 2002 8:743-750 DOI:10.1038/nm726 PMID:12091906
- Barrett, C. M., Lewis, F. L., Roaten, J. B., Sweatman, T. W., Israel, M., Cleveland, J. L., Lothstein, L. Novel extra nuclear-targeted anthracyclines override the antiapoptotic functions of bcl-2 and target protein kinase c pathways to induce apoptosis Molecular Cancer Therapeutics 2002 1:469-481 PMID:12479265
- Eischen, C. M., Rehg, J. E., Korsmeyer, S. J., Cleveland, J. L. Loss of bax alters tumor spectrum and tumor numbers in arf-deficient mice Cancer Research 2002 62:2184-2191 PMID:11929842
- Fee, B. E., Doyle, C. A., Cleveland, J. L. A novel eyes absent 2 protein is expressed in the human eye Gene 2002 285:221-228 DOI:10.1016/s0378-1119(02)00404-3 PMID:12039049
- Clark, S. W., Fee, B. E., Cleveland, J. L. Misexpression of the eyes absent family triggers the apoptotic program Journal of Biological Chemistry 2002 277:3560-3567 DOI:10.1074/jbc.M108410200 PMID:11700312
- Braun, J. S., Sublett, J. E., Freyer, D., Mitchell, T. J., Cleveland, J. L., Tuomanen, E. I., Weber, J. R. Pneumococcal pneumolysin and h2o2 mediate brain cell apoptosis during meningitis Journal of Clinical Investigation 2002 109:19-27 DOI:10.1172/jci12035 PMID:11781347
- Maclean, K. H., Cleveland, J. L., Porter, J. B. Cellular zinc content is a major determinant of iron chelator-induced apoptosis of thymocytes Blood 2001 98:3831-3839 DOI:10.1182/blood.V98.13.3831 PMID:11739193
- Braun, J. S., Novak, R., Murray, P. J., Eischen, C. M., Susin, S. A., Kroemer, G., Halle, A., Weber, J. R., Tuomanen, E. I., Cleveland, J. L. Apoptosis-inducing factor mediates microglial and neuronal apoptosis caused by pneumococcus Journal of Infectious Diseases 2001 184:1300-1309 DOI:10.1086/324013 PMID:11679919
- Eischen, C. M., Roussel, M. F., Korsmeyer, S. J., Cleveland, J. L. Bax loss impairs myc-induced apoptosis and circumvents the selection of p53 mutations during myc-mediated lymphomagenesis Molecular and Cellular Biology 2001 21:7653-7662 DOI:10.1128/mcb.21.22.7653-7662.2001 PMID:11604501
- Eischen, C. M., Packham, G., Nip, J., Fee, B. E., Hiebert, S. W., Zambetti, G. P., Cleveland, J. L. Bcl-2 is an apoptotic target suppressed by both c-myc and e2f-1 Oncogene 2001 20:6983-6993 DOI:10.1038/sj.onc.1204892 PMID:11704823
- Pestina, T. I., Cleveland, J. L., Yang, C. Y., Zambetti, G. P., Jackson, C. W. Mpl ligand prevents lethal myelosuppression by inhibiting p53-dependent apoptosis Blood 2001 98:2084-2090 DOI:10.1182/blood.V98.7.2084 PMID:11567994
- Pendeville, H., Carpino, N., Marine, J. C., Takahashi, Y., Muller, M., Martial, J. A., Cleveland, J. L. The ornithine decarboxylase gene is essential for cell survival during early murine development Molecular and Cellular Biology 2001 21:6549-6558 DOI:10.1128/mcb.21.19.6549-6558.2001 PMID:11533243
- Magnet, K. J., Orr, M. S., Cleveland, J. L., Rodriguez-Galindo, C., Yang, H., Yang, C. Y., Di, Y. M., Jain, P. T., Gewirtz, D. A. Suppression of c-myc expression and c-myc function in response to sustained DNA damage in mcf-7 breast tumor cells Biochemical Pharmacology 2001 62:593-602 DOI:10.1016/s0006-2952(01)00699-2 PMID:11585056
- Drissi, R., Zindy, F., Roussel, M. F., Cleveland, J. L. C-myc-mediated regulation of telomerase activity is disabled in immortalized cells Journal of Biological Chemistry 2001 276:29994-30001 DOI:10.1074/jbc.M101899200 PMID:11402027
- Eischen, C. M., Woo, D., Roussel, M. F., Cleveland, J. L. Apoptosis triggered by myc-induced suppression of bcl-x-l or bcl-2 is bypassed during lymphomagenesis Molecular and Cellular Biology 2001 21:5063-5070 DOI:10.1128/mcb.21.15.5063-5070.2001 PMID:11438662
- Rodriguez-Galindo, C., Poquette, C. A., Daw, N. C., Tan, M., Meyer, W. H., Cleveland, J. L. Circulating concentrations of igf-i and icfbp-3 are not predictive of incidence or clinical behavior of pediatric osteosarcoma Medical and Pediatric Oncology 2001 36:605-611 DOI:10.1002/mpo.1137 PMID:11344491
- Nip, J., Strom, D. K., Eischen, C. M., Cleveland, J. L., Zambetti, G. P., Hiebert, S. W. E2f-1 induces the stabilization of p53 but blocks p53-mediated transactivation Oncogene 2001 20:910-920 DOI:10.1038/sj.onc.1204171 PMID:11314026
- Baudino, T. A., Cleveland, J. L. The max network gone mad Molecular and Cellular Biology 2001 21:691-702 DOI:10.1128/mcb.21.3.691-702.2001 PMID:11154257
- Ruf, I. K., Rhyne, P. W., Yang, H., Borza, C. M., Hutt-Fletcher, L. M., Cleveland, J. L., Sample, J. T. Ebv regulates c-myc, apoptosis, and tumorigenicity in burkitt's lymphoma Current Topics in Microbiology and Immunology 2001 258:153-160 PMID:11443860
- Wen, R. R., Wang, D. M., McKay, C., Bunting, K. D., Marine, J. C., Vanin, E. F., Zambetti, G. P., Korsmeyer, S. J., Ihle, J. N., Cleveland, J. L. Jak3 selectively regulates bax and bcl-2 expression to promote t-cell development Molecular and Cellular Biology 2001 21:678-689 DOI:10.1128/mcb.21.2.678-689.2001 PMID:11134353
- Maclean, K., Yang, H., Cleveland, J. L. Serum suppresses myeloid progenitor apoptosis by regulating iron homeostasis Journal of Cellular Biochemistry 2001 82:171-186 DOI:10.1002/jcb.1111 PMID:11400174
- Alt, J. R., Cleveland, J. L., Hannink, M., Diehl, J. A. Phosphorylation-dependent regulation of cyclin d1 nuclear export and cyclin d1-dependent cellular transformation Genes & Development 2000 14:3102-3114 DOI:10.1101/gad.854900 PMID:11124803 PMCID:PMC317128
- Ruf, I. K., Rhyne, P. W., Yang, C. Y., Cleveland, J. L., Sample, J. T. Epstein-barr virus small rnas potentiate tumorigenicity of burkitt lymphoma cells independently of an effect on apoptosis Journal of Virology 2000 74:10223-10228 DOI:10.1128/jvi.74.21.10223-10228.2000 PMID:11024153
- Inoue, K., Wen, R. R., Rehg, J. E., Adachi, M., Cleveland, J. L., Roussel, M. F., Sherr, C. J. Disruption of the arf transcriptional activator dmp1 facilitates cell immortalization, ras transformation, and tumorigenesis Genes & Development 2000 14:1797-1809 PMID:10898794 PMCID:PMC316790
- Wang, D. M., Wen, R. R., Marine, J. C., Sangster, M. Y., Parganas, E., Hoffmeyer, A., Jackson, C. W., Cleveland, J. L., Ihle, J. N. Phospholipase Cγ2 is essential in the functions of B cell and several Fc receptors Immunity 2000 13:25-35 DOI:10.1016/s1074-7613(00)00005-4 PMID:10933392
- Eischen, C. M., Weber, J. D., Roussel, M. F., Sherr, C. J., Cleveland, J. L. Disruption of the arf-mdm2-p53 tumor suppressor pathway in myc-induced lymphomagenesis Genes & Development 1999 13:2658-2669 DOI:10.1101/gad.13.20.2658 PMID:10541552 PMCID:PMC317106
- Dai, H. Q., Kramer, D. L., Yang, C. Y., Murti, K. G., Porter, C. W., Cleveland, J. L. The polyamine oxidase inhibitor mdl-72,527 selectively induces apoptosis of transformed hematopoietic cells through lysosomotropic effects Cancer Research 1999 59:4944-4954 PMID:10519408
- Ruf, I. K., Rhyne, P. W., Yang, H., Borza, C. M., Hutt-Fletcher, L. M., Cleveland, J. L., Sample, J. T. Epstein-barr virus regulates c-myc, apoptosis, and tumorigenicity in burkitt lymphoma Molecular and Cellular Biology 1999 19:1651-1660 PMID:10022853 PMCID:PMC83959
- Braun, J. S., Novak, R., Herzog, K. H., Bodner, S. M., Cleveland, J. L., Tuomanen, E. I. Neuroprotection by a caspase inhibitor in acute bacterial meningitis Nature Medicine 1999 5:298-302 PMID:10086385
- Florio, M., Hernandez, M. C., Yang, H., Shu, H. K., Cleveland, J. L., Israel, M. A. Id2 promotes apoptosis by a novel mechanism independent of dimerization to basic helix-loop-helix factors Molecular and Cellular Biology 1998 18:5435-5444 PMID:9710627 PMCID:PMC109128
- Packham, G., White, E. L., Eischen, C. M., Yang, H., Parganas, E., Ihle, J. N., Grillot, D. A. M., Zambetti, G. P., Nunez, G., Cleveland, J. L. Selective regulation of bcl-xl by a jak kinase-dependent pathway is bypassed in murine hematopoietic malignancies Genes & Development 1998 12:2475-2487 DOI:10.1101/gad.12.16.2475 PMID:9716401 PMCID:PMC317092
- Zindy, F., Eischen, C. M., Randle, D. H., Kamijo, T., Cleveland, J. L., Sherr, C. J., Roussel, M. F. Myc signaling via the arf tumor suppressor regulates p53-dependent apoptosis and immortalization Genes & Development 1998 12:2424-2433 DOI:10.1101/gad.12.15.2424 PMID:9694806 PMCID:PMC317045
- Frazier, M. W., He, X. P., Wang, J. L., Gu, Z. M., Cleveland, J. L., Zambetti, G. P. Activation of c-myc gene expression by tumor-derived p53 mutants requires a discrete c-terminal domain Molecular and Cellular Biology 1998 18:3735-3743 PMID:9632756 PMCID:PMC108956
- Quelle, F. W., Wang, J. L., Feng, J., Wang, D. M., Cleveland, J. L., Ihle, J. N., Zambetti, G. P. Cytokine rescue of p53-dependent apoptosis and cell cycle arrest is mediated by distinct jak kinase signaling pathways Genes & Development 1998 12:1099-1107 DOI:10.1101/gad.12.8.1099 PMID:9553040 PMCID:PMC316716
- Strom, D. K., Cleveland, J. L., Chellappan, S., Nip, J., Hiebert, S. W. E2f-1 and e2f-3 are functionally distinct in their ability to promote myeloid cell cycle progression and block granulocyte differentiation Cell Growth & Differentiation 1998 9:59-69 PMID:9438389
- Packham, G., Brimmell, M., Cleveland, J. L. Mammalian cells express two differently localized bag-1 isoforms generated by alternative translation initiation Biochemical Journal 1997 328 ( Pt 3):807-813 PMID:9396724 PMCID:PMC1218990
- Brewer, J. W., Cleveland, J. L., Hendershot, L. M. A pathway distinct from the mammalian unfolded protein response regulates expression of endoplasmic reticulum chaperones in non-stressed cells EMBO Journal 1997 16:7207-7216 DOI:10.1093/emboj/16.23.7207 PMID:9384597 PMCID:PMC1170321
- Zhan, Y., Cleveland, J. L., Stevens, J. L. A role for c-myc in chemically induced renal-cell death Molecular and Cellular Biology 1997 17:6755-6764 PMID:9343440 PMCID:PMC232530
- Packham, G., Cleveland, J. L. Induction of ornithine decarboxylase by il-3 is mediated by sequential c-myc-independent and c-myc-dependent pathways Oncogene 1997 15:1219-1232 DOI:10.1038/sj.onc.1201273 PMID:9294616
- Ikushima, S., Inukai, T., Inaba, T., Nimer, S. D., Cleveland, J. L., Look, A. T. Pivotal role for the nfil3/e4bp4 transcription factor in interleukin 3-mediated survival of pro-b lymphocytes Proceedings of the National Academy of Sciences of the United States of America 1997 94:2609-2614 DOI:10.1073/pnas.94.6.2609 PMID:9122243
- Nip, J., Strom, D. K., Fee, B. E., Zambetti, G., Cleveland, J. L., Hiebert, S. W. E2f-1 cooperates with topoisomerase ii inhibition and DNA damage to selectively augment p53-independent apoptosis Molecular and Cellular Biology 1997 17:1049-1056 PMID:9032231 PMCID:PMC231829
- Packham, G., Lahti, J. M., Fee, B. E., Gawn, J. M., CoustanSmith, E., Campana, D., Douglas, I., Kidd, V. J., Ghosh, S., Cleveland, J. L. Fas activates nf-kappa b and induces apoptosis in t-cell lines by signaling pathways distinct from those induced by tnf-alpha Cell Death and Differentiation 1997 4:130-139 DOI:10.1038/sj.cdd.4400217 PMID:16465219
- Packham, G., Porter, C. W., Cleveland, J. L. C-myc induces apoptosis and cell cycle progression by separable, yet overlapping, pathways Oncogene 1996 13:461-469 PMID:8760287
- Packham, G., Ashmun, R. A., Cleveland, J. L. Cytokines suppress apoptosis independent of increases in reactive oxygen levels Journal of Immunology 1996 156:2792-2800 PMID:8609398
- Hiebert, S. W., Packham, G., Strom, D. K., Haffner, R., Oren, M., Zambetti, G., Cleveland, J. L. E2f-1/dp-1 induces p53 and overrides survival factors to trigger apoptosis Molecular and Cellular Biology 1995 15:6864-6874 PMID:8524253 PMCID:PMC230941
- Ofir, R., Novick, I., Krup, M., Cleveland, J. L., Ihle, J. N., Weinstein, Y. Structural and functional analysis of the promoter of the murine v gamma 1.1 t cell receptor gene European Journal of Immunology 1995 25:3070-3078 DOI:10.1002/eji.1830251113 PMID:7489745
- Katzav, S., Packham, G., Sutherland, M., Aroca, P., Santos, E., Cleveland, J. L. Vav and ras induce fibroblast transformation by overlapping signaling pathways, which require c-myc function Oncogene 1995 11:1079-1088 PMID:7566967
- Packham, G., Cleveland, J. L. C-myc and apoptosis Biochimica et Biophysica Acta 1995 1242:11-28 DOI:10.1016/0304-419x(94)00015-t PMID:7626652
- Matsugi, T., Kreider, B. L., Delwel, R., Cleveland, J. L., Askew, D. S., Ihle, J. N. The evi-1 zinc-finger myeloid transforming protein binds to genomic fragments containing (gata)(n) sequences Oncogene 1995 11:191-198 PMID:7624127
- Quelle, F. W., Shimoda, K., Thierfelder, W., Fischer, C., Kim, A., Ruben, S. M., Cleveland, J. L., Pierce, J. H., Keegan, A. D., Nelms, K., Paul, W. E., Ihle, J. N. Cloning of murine stat6 and human stat6, stat proteins that are tyrosine-phosphorylated in responses to il-4 and il-3 but are not required for mitogenesis Molecular and Cellular Biology 1995 15:3336-3343 PMID:7760829 PMCID:PMC230567
- Cleveland, J. L., Ihle, J. N. Contenders in fasl/tnf death signaling Cell 1995 81:479-482 DOI:10.1016/0092-8674(95)90068-3 PMID:7758103
- Weinstein, Y., Askew, D. S., Miura, O., Cleveland, J. L., Ihle, J. N. Regulation of t cell receptor gamma gene expression by cytokines in murine hematopoietic cells European Cytokine Network 1995 6:97-102 PMID:7578993
- Conley, M. E., Fitch-Hilgenberg, M. E., Cleveland, J. L., Parolini, O., Rohrer, J. Screening of genomic DNA to identify mutations in the gene for bruton's tyrosine kinase Human Molecular Genetics 1994 3:1751-1756 DOI:10.1093/hmg/3.10.1751 PMID:7849697
- Packham, G., Cleveland, J. L. Ornithine decarboxylase is a mediator of c-myc-induced apoptosis Molecular and Cellular Biology 1994 14:5741-5747 PMID:8065308 PMCID:PMC359099
- Cleveland, J. L., Troppmair, J., Packham, G., Askew, D. S., Lloyd, P., Gonzalezgarcia, M., Nunez, G., Ihle, J. N., Rapp, U. R. V-raf suppresses apoptosis and promotes growth of interleukin-3-dependent myeloid cells Oncogene 1994 9:2217-2226 PMID:8036007
- Roussel, M. F., Davis, J. N., Cleveland, J. L., Ghysdael, J., Hiebert, S. W. Dual control of myc expression through a single DNA-binding site targeted by ets family proteins and e2f-1 Oncogene 1994 9:405-415 PMID:8290253
- Packham, G., Bello-Fernandez, C., Cleveland, J. L. Position and orientation independent transactivation by c-myc Cellular and Molecular Biology Research 1994 40:699-706 PMID:7787888
- Askew, D. S., Ihle, J. N., Cleveland, J. L. Activation of apoptosis associated with enforced myc expression in myeloid progenitor cells is dominant to the suppression of apoptosis by interleukin-3 or erythropoietin Blood 1993 82:2079-2087 PMID:8400257
- Armstrong, E., Korhonen, J., Silvennoinen, O., Cleveland, J. L., Lieberman, M. A., Alitalo, R. Expression of tie receptor tyrosine kinase in leukemia-cell lines Leukemia 1993 7:1585-1591 PMID:8412320
- Silvennoinen, O., Witthuhn, B. A., Quelle, F. W., Cleveland, J. L., Yi, T. L., Ihle, J. N. Structure of the murine jak2 protein-tyrosine kinase and its role in interleukin-3 signal-transduction Proceedings of the National Academy of Sciences of the United States of America 1993 90:8429-8433 DOI:10.1073/pnas.90.18.8429 PMID:8378315
- Bellofernandez, C., Packham, G., Cleveland, J. L. The ornithine decarboxylase gene is a transcriptional target of c-myc Proceedings of the National Academy of Sciences of the United States of America 1993 90:7804-7808 DOI:10.1073/pnas.90.16.7804 PMID:8356088
- Miura, O., Cleveland, J. L., Ihle, J. N. Inactivation of erythropoietin receptor function by point mutations in a region having homology with other cytokine receptors Molecular and Cellular Biology 1993 13:1788-1795 PMID:8382775 PMCID:PMC359491
- Reynolds, A. B., Herbert, L., Cleveland, J. L., Berg, S. T., Gaut, J. R. P120, a novel substrate of protein tyrosine kinase receptors and of p60v-src is related to cadherin-binding factors beta-catenin, plakoglobin and armadillo Oncogene 1992 7:2439-2445 PMID:1334250
- Okuda, T., Cleveland, J. L., Downing, J. R. Pctaire-1 and pctaire-3, 2 members of a novel cdc2/cdc28-related protein-kinase gene family Oncogene 1992 7:2249-2258 PMID:1437147
- Duyao, M. P., Kessler, D. J., Spicer, D. B., Bartholomew, C., Cleveland, J. L., Siekevitz, M., Sonenshein, G. E. Transactivation of the c-myc promoter by human t-cell leukemia-virus type-1 tax is mediated by nf-kappa-b Journal of Biological Chemistry 1992 267:16288-16291 PMID:1644814
- Rock, C. O., Cleveland, J. L., Jackowski, S. Macrophage growth arrest by cyclic-amp defines a distinct checkpoint in the mid-g(1) stage of the cell-cycle and overrides constitutive c-myc expression Molecular and Cellular Biology 1992 12:2351-2358 PMID:1373814 PMCID:PMC364407
- Yi, T. L., Cleveland, J. L., Ihle, J. N. Protein tyrosine phosphatase containing sh2 domains - characterization, preferential expression in hematopoietic-cells, and localization to human-chromosome 12p12-p13 Molecular and Cellular Biology 1992 12:836-846 PMID:1732748 PMCID:PMC364317
- Yi, T. L., Cleveland, J. L., Ihle, J. N. Identification of novel protein tyrosine phosphatases of hematopoietic cells by polymerase chain reaction amplification Blood 1991 78:2222-2228 PMID:1932742
- Askew, D. S., Ashmun, R. A., Simmons, B. C., Cleveland, J. L. Constitutive c-myc expression in an il-3-dependent myeloid cell-line suppresses cell-cycle arrest and accelerates apoptosis Oncogene 1991 6:1915-1922 PMID:1923514
- Roussel, M. F., Cleveland, J. L., Shurtleff, S. A., Sherr, C. J. Myc rescue of a mutant csf-1 receptor impaired in mitogenic signaling Nature 1991 353:361-363 DOI:10.1038/353361a0 PMID:1833648
- Katzav, S., Cleveland, J. L., Heslop, H. E., Pulido, D. Loss of the amino-terminal helix-loop-helix domain of the vav protooncogene activates its transforming potential Molecular and Cellular Biology 1991 11:1912-1920 PMID:2005887 PMCID:PMC359873
- Beck, T. W., Brennscheidt, U., Sithanandam, G., Cleveland, J., Rapp, U. R. Molecular-organization of the human raf-1 promoter region Molecular and Cellular Biology 1990 10:3325-3333 PMID:1694010 PMCID:PMC360752
- Principato, M., Cleveland, J. L., Rapp, U. R., Holmes, K. L., Pierce, J. H., Morse, H. C., Klinken, S. P. Transformation of murine bone-marrow cells with combined v-raf-v-myc oncogenes yields clonally related mature b-cells and macrophages Molecular and Cellular Biology 1990 10:3562-3568 PMID:2162474 PMCID:PMC360791
- Heidecker, G., Huleihel, M., Cleveland, J. L., Kolch, W., Beck, T. W., Lloyd, P., Pawson, T., Rapp, U. R. Mutational activation of c-raf-1 and definition of the minimal transforming sequence Molecular and Cellular Biology 1990 10:2503-2512 PMID:2188091 PMCID:PMC360607
- Storm, S. M., Cleveland, J. L., Rapp, U. R. Expression of raf family protooncogenes in normal mouse-tissues Oncogene 1990 5:345-351 PMID:1690378
- Cleveland, J. L., Dean, M., Rosenberg, N., Wang, J. Y. J., Rapp, U. R. Tyrosine kinase oncogenes abrogate interleukin-3 dependence of murine myeloid cells through signaling pathways involving c-myc - conditional regulation of c-myc transcription by temperature-sensitive v-abl Molecular and Cellular Biology 1989 9:5685-5695 PMID:2555703 PMCID:PMC363740
- Weinstein, Y., Morishita, K., Cleveland, J. L., Ihle, J. N. Interleukin-3 (il-3) induces transcription from nonrearranged t-cell receptor gamma loci in il-3-dependent cell-lines Journal of Experimental Medicine 1989 169:2059-2071 DOI:10.1084/jem.169.6.2059 PMID:2543731
- Greil, R., Gattringer, C., Fasching, B., Cleveland, J., Thaler, J., Radaskiewicz, T., Gastl, G., Huber, C., Rapp, U., Huber, H. Abl oncogene expression in non-hodgkin lymphomas: Correlation to histological differentiation and clinical status International Journal of Cancer 1988 42:529-538 DOI:10.1002/ijc.2910420410 PMID:3049401
- Farrar, W. L., Vinocour, M., Cleveland, J. L., Harelbellan, A. Regulation of ornithine decarboxylase activity by il-2 and cyclic-amp Journal of Immunology 1988 141:967-971 PMID:2840461
- Cleveland, J. L., Dean, M., Wang, J. Y., Hedge, A. M., Ihle, J. N., Rapp, U. R. Abrogation of il-3 dependence of myeloid fdc-p1 cells by tyrosine kinase oncogenes is associated with induction of c-myc Current Topics in Microbiology and Immunology 1988 141:300-309 PMID:3265092
- Horton, W. E., Jr., Cleveland, J., Rapp, U., Nemuth, G., Bolander, M., Doege, K., Yamada, Y., Hassell, J. R. An established rat cell line expressing chondrocyte properties Experimental Cell Research 1988 178:457-468 DOI:10.1016/0014-4827(88)90414-4 PMID:3049123
- Dean, M., Cleveland, J., Kim, H. Y., Campisi, J., Levine, R. A., Ihle, J. N., Rapp, U. Deregulation of the c-myc and n-myc genes in transformed cells Current Topics in Microbiology and Immunology 1988 141:216-222 PMID:3215051
- Principato, M., Klinken, S. P., Cleveland, J. L., Rapp, U. R., Holmes, K. L., Pierce, J. H., Morse, H. C. In vitro transformation of murine bone marrow cells with a v-raf/v-myc retrovirus yields clonally related mature b cells and macrophages Current Topics in Microbiology and Immunology 1988 141:31-41 PMID:3265093
- Cleveland, J. L., Morse, H. C., Rapp, U. R. Myc oncogenes and tumor-induction ISI Atlas of Science-Biochemistry 1988 1:93-100
- Troppmair, J., Huleihel, M., Cleveland, J., Mushinski, J. F., Kurie, J., Morse, H. C., Wax, J. S., Potter, M., Rapp, U. R. Plasmacytoma induction by j series of v-myc recombinant retroviruses: Evidence for the requirement of two (raf and myc) oncogenes for transformation Current Topics in Microbiology and Immunology 1988 141:110-114 PMID:3215044
- Rapp, U. R., Heidecker, G., Huleihel, M., Cleveland, J. L., Choi, W. C., Pawson, T., Ihle, J. N., Anderson, W. B. Raf family serine/threonine protein kinases in mitogen signal transduction Cold Spring Harbor Symposia on Quantitative Biology 1988 53:173-184 PMID:2978288
- Farrar, W. L., Evans, S. W., Rapp, U. R., Cleveland, J. L. Effects of antiproliferative cyclic-amp on interleukin 2-stimulated gene-expression Journal of Immunology 1987 139:2075-2080 PMID:3040863
- Weinstein, Y., Cleveland, J. L., Askew, D. S., Rapp, U. R., Ihle, J. N. Insertion and truncation of c-myb by murine leukemia-virus in a myeloid cell-line derived from cultures of normal hematopoietic-cells Journal of Virology 1987 61:2339-2343 PMID:2884332 PMCID:PMC283705
- Cleveland, J. L., Rapp, U. R., Farrar, W. L. Role of c-myc and other genes in interleukin-2 regulated ct6 lymphocytes-t and their malignant variants Journal of Immunology 1987 138:3495-3504 PMID:3106484
- Dean, M., Cleveland, J. L., Rapp, U. R., Ihle, J. N. Role of myc in the abrogation of il3 dependence of myeloid fdc-p1 cells Oncogene Research 1987 1:279-296 PMID:2453016
- Morse, H. C., Hartley, J. W., Fredrickson, T. N., Yetter, R. A., Majumdar, C., Cleveland, J. L., Rapp, U. R. Recombinant murine retroviruses containing avian v-myc induce a wide spectrum of neoplasms in newborn mice Proceedings of the National Academy of Sciences of the United States of America 1986 83:6868-6872 DOI:10.1073/pnas.83.18.6868 PMID:3018749
- Huleihel, M., Goldsborough, M., Cleveland, J., Gunnell, M., Bonner, T., Rapp, U. R. Characterization of murine a-raf, a new oncogene related to the v-raf oncogene Molecular and Cellular Biology 1986 6:2655-2662 PMID:3491291 PMCID:PMC367822
- Huebner, K., Arrushdi, A., Griffin, C. A., Isobe, M., Kozak, C., Emanuel, B. S., Nagarajan, L., Cleveland, J. L., Bonner, T. I., Goldsborough, M. D., Croce, C. M., Rapp, U. Actively transcribed genes in the raf oncogene group, located on the x-chromosome in mouse and human Proceedings of the National Academy of Sciences of the United States of America 1986 83:3934-3938 DOI:10.1073/pnas.83.11.3934 PMID:3520560
- Farrar, W. L., Cleveland, J. L., Beckner, S. K., Bonvini, E., Evans, S. W. Biochemical and molecular events associated with interleukin 2 regulation of lymphocyte proliferation Immunological Reviews 1986 92:49-65 DOI:10.1111/j.1600-065X.1986.tb01493.x PMID:3091482
- Cleveland, J. L., Jansen, H. W., Bister, K., Fredrickson, T. N., Morse, H. C., Ihle, J. N., Rapp, U. R. Interaction between Raf and Myc oncogenes in transformation in vivo and in vitro Journal of Cellular Biochemistry 1986 30:195-218 DOI:10.1002/jcb.240300303 PMID:3084503
- Cleveland, J. L., Weinstein, Y., Ihle, J. N., Askew, D. S., Rapp, U. R. Transformation and insertional mutagenesis in vitro of primary hematopoietic stem cell cultures Current Topics in Microbiology and Immunology 1986 132:44-54 PMID:3024923
- Morse, H. C., 3rd, Hartley, J. W., Fredrickson, T. N., Yetter, R. A., Cleveland, J. L., Majumdar, C., Rapp, U. R. Tumors of newborn nfs/n mice infected with murine retroviruses containing avian v-myc Current Topics in Microbiology and Immunology 1986 132:17-22 PMID:3024912
- Rapp, U. R., Cleveland, J. L., Brightman, K., Scott, A., Ihle, J. N. Abrogation of IL-3 and IL-2 dependence by recombinant murine retroviruses expressing v-myc oncogenes Nature 1985 317:434-438 DOI:10.1038/317434a0 PMID:3930972
- Rapp, U. R., Cleveland, J. L., Fredrickson, T. N., Holmes, K. L., Morse, H. C., Jansen, H. W., Patschinsky, T., Bister, K. Rapid induction of hemopoietic neoplasms in newborn mice by a raf(mil)/myc recombinant murine retrovirus Journal of Virology 1985 55:23-33 PMID:4009794 PMCID:PMC254893
- Blasi, E., Mathieson, B. J., Varesio, L., Cleveland, J. L., Borchert, P. A., Rapp, U. R. Selective immortalization of murine macrophages from fresh bone-marrow by a raf/myc recombinant murine retrovirus Nature 1985 318:667-670 DOI:10.1038/318667a0 PMID:4079980
thesis
- Characterization of gene expression from the EcoRI F region of the herpes simplex virus type I genome 1985

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