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Cleveland, John
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Cleveland, John

Faculty Member
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Positions

  • 2006 - 2014 Chairman, Cancer Biology , Scripps Research
  • 2006 - 2014 Professor, Cancer Biology , Scripps Research
  • 2006 - 2014 Faculty Member, Skaggs Graduate School of Chemical and Biological Sciences , Scripps Research
Dr. John L. Cleveland studies the molecular basis of cancer with a focus on malignancies having myc involvement, which is activated in 70% of all human cancers. Target discovery validation using mouse models, and cancer prevention and therapeutics are the major focuses of the laboratory.

Research Areas research areas

  • Apoptosis
  • Cancer
  • Cancer Genetics
  • Cancer Prevention
  • Cancer Therapeutics
  • neoplasms (UMLS)
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Publications

recent publications

  • academic article

    • Zahedi, K., Brooks, M., Barone, S., Rahmati, N., Stewart, T. M., Dunworth, M., Destefano-Shields, C., Dasgupta, N., Davidson, S., Lindquist, D. M., Fuller, C. E., Smith, R. D., et al. Ablation of polyamine catabolic enzymes provokes Purkinje cell damage, neuroinflammation, and severe ataxia Journal of Neuroinflammation  2020 17  DOI:10.1186/s12974-020-01955-6  PMID:33054763  PMCID:PMC7559641
    • Kwong, T., Ma, M., Pan, G., Hindra, Yang, D., Yang, C., Lohman, J. R., Rudolf, J. D., Cleveland, J. L., Shen, B. P450-catalyzed tailoring steps in leinamycin biosynthesis featuring regio- and stereoselective hydroxylations and substrate promiscuities Biochemistry  2018 57:5005-5013  DOI:10.1021/acs.biochem.8b00623  PMID:30070831  PMCID:PMC6211295
    • Getun, I. V., Wu, Z., Fallahi, M., Ouizem, S., Liu, Q., Li, W., Costi, R., Roush, W. R., Cleveland, J. L., Bois, P. R. J. Functional roles of acetylated histone marks at mouse meiotic recombination hot spots Molecular and Cellular Biology  2017 37:UNSP e00942-15  DOI:10.1128/mcb.00942-15  PMID:27821479  PMCID:PMC5247613
    • Pan, X., Yang, C., Cleveland, J. L., Bannister, T. D. Synthesis and cytoxicity of sempervirine and analogues Journal of Organic Chemistry  2016 81:2194-2200  DOI:10.1021/acs.joc.6b00022  PMID:26828413
    • Nair, R. N., Mishra, J. K., Li, F., Tortosa, M., Yang, C., Doherty, J. R., Cameron, M., Cleveland, J. L., Roush, W. R., Bannister, T. D. Exploiting the co-reliance of tumours upon transport of amino acids and lactate: Gln and Tyr conjugates of MCT1 inhibitors MedChemComm  2016 7:900-905  DOI:10.1039/c5md00579e  PMID:27347360
    • Rosenberg, L. H., Lafitte, M., Quereda, V., Grant, W., Chen, W., Bibian, M., Noguchi, Y., Fallahi, M., Yang, C., Chang, J. C., Roush, W. R., Cleveland, J. L., et al. Therapeutic targeting of casein kinase 1δ in breast cancer Science Translational Medicine  2015 7:318ra202  DOI:10.1126/scitranslmed.aac8773  PMID:26676609  PMCID:PMC4809734
    • Schaub, F. X., Reza, M. S., Flaveny, C. A., Li, W., Musicant, A. M., Hoxha, S., Guo, M., Cleveland, J. L., Amelio, A. L. Fluorophore-NanoLuc BRET reporters enable sensitive in vivo optical imaging and flow cytometry for monitoring tumorigenesis Cancer Research  2015 75:5023-5033  DOI:10.1158/0008-5472.can-14-3538  PMID:26424696  PMCID:PMC4668208
    • Liu, T., Ma, M., Ge, H. M., Yang, C., Cleveland, J., Shen, B. Synthesis and evaluation of 8,4 '-dideshydroxy-leinamycin revealing new insights into the structure-activity relationship of the anticancer natural product leinamycin Bioorganic & Medicinal Chemistry Letters  2015 25:4899-4902  DOI:10.1016/j.bmcl.2015.05.078  PMID:26071634  PMCID:PMC4607584
    • Liu, T., Ma, M., Ge, H. M., Yang, C., Cleveland, J., Shen, B. Synthesis and evaluation of 8,4'-dideshydroxy-leinamycin revealing new insights into the structure-activity relationship of the anticancer natural product leinamycin Bioorganic & Medicinal Chemistry Letters  2015  DOI:10.1016/j.bmcl.2015.05.078  PMID:26071634  PMCID:PMC4607584
    • Rosenberg, L. H., Lafitte, M., Grant, W., Chen, W., Cleveland, J. L., Duckett, D. R. Development of an HTS-compatible assay for the discovery of Ulk1 inhibitors Journal of Biomolecular Screening  2015 20:913-920  DOI:10.1177/1087057115579391  PMID:25851035  PMCID:PMC4744088
    • Ghalei, H., Schaub, F. X., Doherty, J. R., Noguchi, Y., Roush, W. R., Cleveland, J. L., Stroupe, M. E., Karbstein, K. Hrr25/CK1 delta-directed release of Ltv1 from pre-40S ribosomes is necessary for ribosome assembly and cell growth Journal of Cell Biology  2015 208:745-759  DOI:10.1083/jcb.201409056  PMID:25778921  PMCID:PMC4362465
    • Fallahi, M., Amelio, A. L., Cleveland, J. L., Rounbehler, R. J. CREB targets define the gene expression signature of malignancies having reduced levels of the tumor suppressor tristetraprolin PLoS One  2014 9:e115517  DOI:10.1371/journal.pone.0115517  PMID:25541715  PMCID:PMC4277357
    • Seo, J. W., Ma, M., Kwong, T., Ju, J., Lim, S. K., Jiang, H., Lohman, J. R., Yang, C., Cleveland, J., Zazopoulos, E., Farnet, C. M., Shen, B. Comparative characterization of the lactimidomycin and iso-migrastatin biosynthetic machineries revealing unusual features for acyltransferase-less type I polyketide synthases and providing an opportunity to engineer new analogues Biochemistry  2014 53:7854-7865  DOI:10.1021/bi501396v  PMID:25405956  PMCID:PMC4270375
    • Hoellein, A., Fallahi, M., Schoeffmann, S., Steidle, S., Schaub, F. X., Rudelius, M., Laitinen, I., Nilsson, L., Goga, A., Peschel, C., Nilsson, J. A., Cleveland, J. L., et al. Myc-induced SUMOylation is a therapeutic vulnerability for B-cell lymphoma Blood  2014 124:2081-2090  DOI:10.1182/blood-2014-06-584524  PMID:25143484  PMCID:PMC4186537
    • Wang, H., Yang, C., Doherty, J. R., Roush, W. R., Cleveland, J. L., Bannister, T. D. Synthesis and structure-activity relationships of pteridine dione and trione monocarboxylate transporter 1 inhibitors Journal of Medicinal Chemistry  2014 57:7317-7324  DOI:10.1021/jm500640x  PMID:25068893  PMCID:PMC4161152
    • Amelio, A. L., Fallahi, M., Schaub, F. X., Zhang, M., Lawani, M. B., Alperstein, A. S., Southern, M. R., Young, B. M., Wu, L., Zajac-Kaye, M., Kaye, F. J., Cleveland, J. L., et al. CRTC1/MAML2 gain-of-function interactions with MYC create a gene signature predictive of cancers with CREB-MYC involvement Proceedings of the National Academy of Sciences of the United States of America  2014 111:E3260-E3268  DOI:10.1073/pnas.1319176111  PMID:25071166  PMCID:PMC4136562
    • Lu, Y., Wu, Y., Feng, X., Shen, R., Wang, J. H., Fallahi, M., Li, W., Yang, C., Hankey, W., Zhao, W., Ganju, R. K., Li, M. O., et al. CDK4 deficiency promotes genomic instability and enhances Myc-driven lymphomagenesis Journal of Clinical Investigation  2014 124:1672-1684  DOI:10.1172/jci63139  PMID:24614102  PMCID:PMC3973114
    • Doherty, J. R., Yang, C., Scott, K. E. N., Cameron, M. D., Fallahi, M., Li, W., Hall, M. A., Amelio, A. L., Mishra, J. K., Li, F., Tortosa, M., Genau, H. M., et al. Blocking lactate export by inhibiting the Myc target MCT1 disables glycolysis and glutathione synthesis Cancer Research  2014 74:908-920  DOI:10.1158/0008-5472.can-13-2034  PMID:24285728  PMCID:PMC3946415
    • Canterbury, D. P., Scott, K. E. N., Kubo, O., Jansen, R., Cleveland, J. L., Micalizio, G. C. Synthesis of C11-desmethoxy soraphen A(1 alpha): a natural product analogue that inhibits acetyl-CoA carboxylase ACS Medicinal Chemistry Letters  2013 4:1244-1248  DOI:10.1021/ml400377p  PMID:24639892  PMCID:PMC3951358
    • Doherty, J. R., Cleveland, J. L. Targeting lactate metabolism for cancer therapeutics Journal of Clinical Investigation  2013 123:3685-3692  DOI:10.1172/jci69741  PMID:23999443  PMCID:PMC3754272
    • Bibian, M., Rahaim, R. J., Choi, J. Y., Noguchi, Y., Schurer, S., Chen, W. M., Nakanishi, S., Licht, K., Rosenberg, L. H., Li, L., Feng, Y., Cameron, M. D., et al. Development of highly selective casein kinase 1δ/1ε (CK1δ/ε) inhibitors with potent antiproliferative properties Bioorganic & Medicinal Chemistry Letters  2013 23:4374-4380  DOI:10.1016/j.bmcl.2013.05.075  PMID:23787102  PMCID:PMC3783656
    • Jeso, V., Yang, C., Cameron, M. D., Cleveland, J. L., Micalizio, G. C. Synthesis and SAR of lehualide B: A marine-derived natural product with potent anti-multiple myeloma activity ACS Chemical Biology  2013 8:1241-1252  DOI:10.1021/cb300582s  PMID:23547759  PMCID:PMC3758376
    • Rounbehler, R. J., Fallahi, M., Yang, C. Y., Steeves, M. A., Li, W. M., Doherty, J. R., Schaub, F. X., Sanduja, S., Dixon, D. A., Blackshear, P. J., Cleveland, J. L. Tristetraprolin impairs myc-induced lymphoma and abolishes the malignant state Cell  2012 150:563-574  DOI:10.1016/j.cell.2012.06.033  PMID:22863009  PMCID:PMC3422762
    • Valentin-Vega, Y. A., MacLean, K. H., Tait-Mulder, J., Milasta, S., Steeves, M., Dorsey, F. C., Cleveland, J. L., Green, D. R., Kastan, M. B. Mitochondrial dysfunction in ataxia-telangiectasia Blood  2012 119:1490-1500  DOI:10.1182/blood-2011-08-373639  PMID:22144182  PMCID:PMC3286212
    • Ji, H. K., Wu, G., Zhan, X. C., Nolan, A., Koh, C., De Marzo, A., Doan, H. M., Fan, J. S., Cheadle, C., Fallahi, M., Cleveland, J. L., Dang, C. V., et al. Cell-type independent myc target genes reveal a primordial signature involved in biomass accumulation PLoS One  2011 6:e26057  DOI:10.1371/journal.pone.0026057  PMID:22039435  PMCID:PMC3198433
    • Joo, J. H., Dorsey, F. C., Joshi, A., Hennessy-Walters, K. M., Rose, K. L., McCastlain, K., Zhang, J., Iyengar, R., Jung, C. H., Suen, D. F., Steeves, M. A., Yang, C. Y., et al. Hsp90-cdc37 chaperone complex regulates ulk1-and atg13-mediated mitophagy Molecular Cell  2011 43:572-585  DOI:10.1016/j.molcel.2011.06.018  PMID:21855797  PMCID:PMC3485687
    • Ouellette, S. P., Dorsey, F. C., Moshiach, S., Cleveland, J. L., Carabeo, R. A. Chlamydia species-dependent differences in the growth requirement for lysosomes PLoS One  2011 6:e16783  DOI:10.1371/journal.pone.0016783  PMID:21408144  PMCID:PMC3050816
    • den Hollander, J., Rimpi, S., Doherty, J. R., Rudelius, M., Buck, A., Hoellein, A., Kremer, M., Graf, N., Scheerer, M., Hall, M. A., Goga, A., von Bubnoff, N., et al. Aurora kinases a and b are up-regulated by myc and are essential for maintenance of the malignant state Blood  2010 116:1498-1505  DOI:10.1182/blood-2009-11-251074  PMID:20519624  PMCID:PMC2938839
    • Keller, U., Huber, J., Nilsson, J. A., Fallahi, M., Hall, M. A., Peschel, C., Cleveland, J. L. Myc suppression of nfkb2 accelerates lymphomagenesis BMC Cancer  2010 10:348  DOI:10.1186/1471-2407-10-348  PMID:20598117  PMCID:PMC2902445
    • Rethman, M. P., Carpenter, W., Cohen, E. E. W., Epstein, J., Evans, C. A., Flaitz, C. M., Graham, F. J., Hujoel, P. P., Kalmar, J. R., Koch, W. M., Lambert, P. M., Lingen, M. W., et al. Evidence-based clinical recommendations regarding screening for oral squamous cell carcinomas Journal of the American Dental Association  2010 141:509-520  PMID:20436098
    • Steeves, M. A., Dorsey, F. C., Cleveland, J. L. Targeting the autophagy pathway for cancer chemoprevention Current Opinion in Cell Biology  2010 22:218-225  DOI:10.1016/j.ceb.2009.12.013  PMID:20096553  PMCID:PMC2854265
    • Old, J. B., Kratzat, S., Hoellein, A., Graf, S., Nilsson, J. A., Nilsson, L., Nakayama, K. I., Peschel, C., Cleveland, J. L., Keller, U. B. Skp2 directs myc-mediated suppression of p27(kip1) yet has modest effects on myc-driven lymphomagenesis Molecular Cancer Research  2010 8:353-362  DOI:10.1158/1541-7786.mcr-09-0232  PMID:20197382  PMCID:PMC3095030
    • Dorsey, F. C., Rose, K. L., Coenen, S., Prater, S. M., Cavett, V., Cleveland, J. L., Caldwell-Busby, J. Mapping the phosphorylation sites of ulk1 Journal of Proteome Research  2009 8:5253-5263  DOI:10.1021/pr900583m  PMID:19807128
    • Zhang, J., Randall, M. S., Loyd, M. R., Dorsey, F. C., Kundu, M., Cleveland, J. L., Ney, P. A. Mitochondrial clearance is regulated by atg7-dependent and -independent mechanisms during reticulocyte maturation Blood  2009 114:157-164  DOI:10.1182/blood-2008-04-151639  PMID:19417210  PMCID:PMC2710944
    • Rounbehler, R. J., Li, W. M., Hall, M. A., Yang, C. Y., Fallahi, M., Cleveland, J. L. Targeting ornithine decarboxylase impairs development of mycn-amplified neuroblastoma Cancer Research  2009 69:547-553  DOI:10.1158/0008-5472.can-08-2968  PMID:19147568  PMCID:PMC2749594
    • Nawrocki, S. T., Carew, J. S., Maclean, K. H., Courage, J. F., Huang, P., Houghton, J. A., Cleveland, J. L., Giles, F. J., McConkey, D. J. Myc regulates aggresome formation, the induction of noxa, and apoptosis in response to the combination of bortezomib and saha Blood  2008 112:2917-2926  DOI:10.1182/blood-2007-12-130823  PMID:18641367  PMCID:PMC2556625
    • Garrison, S. P., Jeffers, J. R., Yang, C. Y., Nilsson, J. A., Hall, M. A., Rehg, J. E., Yue, W., Yu, J., Zhang, L., Onciu, M., Sample, J. T., Cleveland, J. L., et al. Selection against puma gene expression in myc-driven b-cell lymphomagenesis Molecular and Cellular Biology  2008 28:5391-5402  DOI:10.1128/mcb.00907-07  PMID:18573879  PMCID:PMC2519737
    • Carew, J. S., Nawrocki, S. T., Reddy, V. A., Bush, D., Rehg, J. E., Goodwin, A., Houghton, J. A., Casero, R. A., Marton, L. J., Cleveland, J. L. The novel polyamine analogue CGC-11093 enhances the antimyeloma activity of bortezomib Cancer Research  2008 68:4783-4790  DOI:10.1158/0008-5472.can-07-6483  PMID:18559525  PMCID:PMC2749595
    • Rodrigues, C. O., Nerlick, S. T., White, E. L., Cleveland, J. L., King, M. L. A myc-slug (snail2)/twist regulatory circuit directs vascular development Development  2008 135:1903-1911  DOI:10.1242/dev.011296  PMID:18469221  PMCID:PMC2741485
    • Klionsky, D. J., Abeliovich, H., Agostinis, P., Agrawal, D. K., Aliev, G., Askew, D. S., Baba, M., Baehrecke, E. H., Bahr, B. A., Ballabio, A., Bamber, B. A., Bassham, D. C., et al. Guidelines for the use and interpretation of assays for monitoring autophagy in higher eukaryotes Autophagy  2008 4:151-175  PMID:18188003  PMCID:PMC2654259
    • Maclean, K. H., Dorsey, F. C., Cleveland, J. L., Kastan, M. B. Targeting lysosomal degradation induces p53-dependent cell death and prevents cancer in mouse models of lymphomagenesis Journal of Clinical Investigation  2008 118:79-88  DOI:10.1172/jci33700  PMID:18097482  PMCID:PMC2148253
    • Sanjuan, M. A., Dillon, C. P., Tait, S. W. G., Moshiach, S., Dorsey, F., Connell, S., Komatsu, M., Tanaka, K., Cleveland, J. L., Withoff, S., Green, D. R. Toll-like receptor signalling in macrophages links the autophagy pathway to phagocytosis Nature  2007 450:1253-1257  DOI:10.1038/nature06421  PMID:18097414
    • Schweers, R. L., Zhang, J., Randall, M. S., Loyd, M. R., Li, W., Dorsey, F. C., Kundu, M., Opferman, J. T., Cleveland, J. L., Miller, J. L., Ney, P. A. Nix is required for programmed mitochondrial clearance during reticulocyte maturation Proceedings of the National Academy of Sciences of the United States of America  2007 104:19500-19505  DOI:10.1073/pnas.0708818104  PMID:18048346  PMCID:PMC2148318
    • Carew, J. S., Nawrocki, S. T., Cleveland, J. L. Modulating autophagy for therapeutic benefit Autophagy  2007 3:464-467  PMID:17495516
    • Nawrocki, S. T., Carew, J. S., Donglas, L., Cleveland, J. L., Humphreys, R., Houghton, J. A. Histone deacetylase inhibitors enhance lexaturnurnab-induced apoptosis via a p21(cip1)-dependent decrease in survivin levels Cancer Research  2007 67:6987-6994  DOI:10.1158/0008-5472.can-07-0812  PMID:17638911
    • Maclean, K. H., Kastan, M. B., Cleveland, J. L. Atm deficiency affects both apoptosis and proliferation to augment myc-induced lymphomagenesis Molecular Cancer Research  2007 5:705-711  DOI:10.1158/1541-7786.mcr-07-0058  PMID:17634425
    • Carew, J. S., Nawrocki, S. T., Kahue, C. N., Zhang, H., Yang, C. Y., Chung, L., Houghton, J. A., Huang, P., Giles, F. J., Cleveland, J. L. Targeting autophagy augments the anticancer activity of the histone deacetylase inhibitor saha to overcome bcr-abl-mediated drug resistance Blood  2007 110:313-322  DOI:10.1182/blood-2006-10-050260  PMID:17363733  PMCID:PMC1896119
    • Keller, U. B., Old, J. B., Dorsey, F. C., Nilsson, J. A., Nilsson, L., MacLean, K. H., Chung, L., Yang, C. Y., Spruck, C., Boyd, K., Reed, S. I., Cleveland, J. L. Myc targets cks1 to provoke the suppression of p27(kip1), proliferation and lymphomagenesis EMBO Journal  2007 26:2562-2574  DOI:10.1038/sj.emboj.7601691  PMID:17464290  PMCID:PMC1868903
    • Nilsson, L. M., Keller, U. B., Yang, C., Nilsson, J. A., Cleveland, J. L., Roussel, M. F. Ink4c is dispensable for tumor suppression in myc-induced b-cell lymphomagenesis Oncogene  2007 26:2833-2839  DOI:10.1038/sj.onc.1210104  PMID:17099725
    • Wen, R. R., Chen, Y. H., Bai, L., Fu, G. P., Schuman, J., Dai, X. Z., Zeng, H., Yang, C. Y., Stephan, R. P., Cleveland, J. L., Wang, D. M. Essential role of phospholipase c gamma 2 in early b-cell development and myc-mediated lymphomagenesis Molecular and Cellular Biology  2006 26:9364-9376  DOI:10.1128/mcb.00839-06  PMID:17030619
    • Moreno-Miralles, I., Pan, L., Keates-Baleeiro, J., Durst-Goodwin, K., Yang, C. Y., Kim, H. G., Thompson, M. A., Klug, C. A., Cleveland, J. L., Hiebert, S. W. The inv(16) cooperates with arf haploinsufficiency to induce acute myeloid leukemia Journal of Biological Chemistry  2005 280:40097-40103  DOI:10.1074/jbc.M506855200  PMID:16199529
    • Kasper, L. H., Boussouar, F., Boyd, K., Xu, W., Biesen, M., Rehg, J., Baudino, T. A., Cleveland, J. L., Brindle, P. K. Two transactivation mechanisms cooperate for the bulk of hif-1-responsive gene expression EMBO Journal  2005 24:3846-3858  DOI:10.1038/sj.emboj.7600846  PMID:16237459  PMCID:PMC1283945
    • Bois, P. R. J., Brochard, V. F., Salin-Cantegrel, A. V. A., Cleveland, J. L., Grosveld, G. C. Foxo1a-cyclic gmp-dependent kinase i interactions orchestrate myoblast fusion Molecular and Cellular Biology  2005 25:7645-7656  DOI:10.1128/mcb.25.17.7645-7656.2005  PMID:16107711
    • Keller, U., Nilsson, J. A., Maclean, K. H., Old, J. B., Cleveland, J. L. Nfkb1 is dispensable for myc-induced lymphomagenesis Oncogene  2005 24:6231-6240  DOI:10.1038/sj.onc.1208779  PMID:15940251
    • Ulett, G. C., Maclean, K. H., Nekkalapu, S., Cleveland, J. L., Adderson, E. E. Mechanisms of group b streptococcal-induced apoptosis of murine macrophages Journal of Immunology  2005 175:2555-2562  PMID:16081829
    • Hemann, M. T., Bric, A., Teruya-Feldstein, J., Herbst, A., Nilsson, J. A., Cordon-Cardo, C., Cleveland, J. L., Tansey, W. P., Lowe, S. W. Evasion of the p53 tumour surveillance network by tumour-derived myc mutants Nature  2005 436:807-811  DOI:10.1038/nature03845  PMID:16094360  PMCID:PMC4599579
    • Nilsson, J. A., Keller, U. B., Baudino, T. A., Yang, C. Y., Norton, S., Old, J. A., Nilsson, L. M., Neale, G., Kramer, D. L., Porter, C. W., Cleveland, J. L. Targeting ornithine decarboxylase in myc-induced lymphomagenesis prevents tumor formation Cancer Cell  2005 7:433-444  DOI:10.1016/j.ccr.2005.03.036  PMID:15894264
    • Cardone, M., Kandilci, A., Carella, C., Nilsson, J. A., Brennan, J. A., Sirma, S., Ozbek, U., Boyd, K., Cleveland, J. L., Grosveld, G. C. The novel ets factor tel2 cooperates with myc in b lymphomagenesis Molecular and Cellular Biology  2005 25:2395-2405  DOI:10.1128/mcb.25.6.2395-2405.2005  PMID:15743832
    • Guo, Y. J., Cleveland, J. L., O'Brien, T. G. Haploinsufficiency for odc modifies mouse skin tumor susceptibility Cancer Research  2005 65:1146-1149  DOI:10.1158/0008-5472.can-04-3244  PMID:15734996
    • Nilsson, J. A., Nilsson, L. M., Keller, U., Yokota, Y., Boyd, K., Cleveland, J. L. Id2 is dispensable for myc-induced lymphomagenesis Cancer Research  2004 64:7296-7301  DOI:10.1158/0008-5472.can-04-2133  PMID:15492249
    • Nilsson, J. A., Cleveland, J. L. Mnt: Master regulator of the max network Cell Cycle  2004 3:588-590  PMID:15107624
    • Nilsson, J. A., Maclean, K. H., Keller, U. B., Pendeville, H., Baudino, T. A., Cleveland, J. L. Mnt loss triggers myc transcription targets, proliferation, apoptosis, and transformation Molecular and Cellular Biology  2004 24:1560-1569  DOI:10.1128/mcb.24.4.1560-1569.2004  PMID:14749372
    • Zindy, F., Williams, R. T., Baudino, T. A., Rehg, J. E., Skapek, S. X., Cleveland, J. L., Roussel, M. F., Sherr, C. J. Arf tumor suppressor promoter monitors latent oncogenic signals in vivo Proceedings of the National Academy of Sciences of the United States of America  2003 100:15930-15935  DOI:10.1073/pnas.02536808100  PMID:14665695
    • Nilsson, J. A., Cleveland, J. L. Myc pathways provoking cell suicide and cancer Oncogene  2003 22:9007-9021  DOI:10.1038/sj.onc.1207261  PMID:14663479
    • Maclean, K. H., Keller, U. B., Rodriguez-Galindo, C., Nilsson, J. A., Cleveland, J. L. C-myc augments gamma irradiation-induced apoptosis by suppressing bcl-x-l Molecular and Cellular Biology  2003 23:7256-7270  DOI:10.1128/mcb.23.20.7256-7270.2003  PMID:14517295
    • Jeffers, J. R., Parganas, E., Lee, Y., Yang, C. Y., Wang, J. L., Brennan, J., MacLean, K. H., Han, J. W., Chittenden, T., Ihle, J. N., McKinnon, P. J., Cleveland, J. L., et al. Puma is an essential mediator of p53-dependent and -independent apoptotic pathways Cancer Cell  2003 4:321-328  DOI:10.1016/s1535-6108(03)00244-7  PMID:14585359
    • Baudino, T. A., Maclean, K. H., Brennan, J., Parganas, E., Yang, C. Y., Aslanian, A., Lees, J. A., Sherr, C. J., Roussel, M. F., Cleveland, J. L. Myc-mediated proliferation and lymphomagenesis, but not apoptosis, are compromised by e2f1 loss Molecular Cell  2003 11:905-914  DOI:10.1016/s1097-2765(03)00102-3  PMID:12718877
    • Alt, J. R., Greiner, T. C., Cleveland, J. L., Eischen, C. M. Mdm2 haplo-insufficiency profoundly inhibits myc-induced lymphomagenesis EMBO Journal  2003 22:1442-1450  DOI:10.1093/emboj/cdg133  PMID:12628936  PMCID:PMC151074
    • Baudino, T. A., McKay, C., Pendeville-Samain, H., Nilsson, J. A., Maclean, K. H., White, E. L., Davis, A. C., Ihle, J. N., Cleveland, J. L. C-myc is essential for vasculogenesis and angiogenesis during development and tumor progression Genes & Development  2002 16:2530-2543  DOI:10.1101/gad.1024602  PMID:12368264  PMCID:PMC187450
    • Linggi, B., Muller-Tidow, C., van de Locht, L., Hu, M., Nip, J., Serve, H., Berdel, W. E., van der Reijden, B., Quelle, D. E., Rowley, J. D., Cleveland, J., Jansen, J. H., et al. The t(8;21) fusion protein, aml1-eto, specifically represses the transcription of the p14(arf) tumor suppressor in acute myeloid leukemia Nature Medicine  2002 8:743-750  DOI:10.1038/nm726  PMID:12091906
    • Barrett, C. M., Lewis, F. L., Roaten, J. B., Sweatman, T. W., Israel, M., Cleveland, J. L., Lothstein, L. Novel extra nuclear-targeted anthracyclines override the antiapoptotic functions of bcl-2 and target protein kinase c pathways to induce apoptosis Molecular Cancer Therapeutics  2002 1:469-481  PMID:12479265
    • Eischen, C. M., Rehg, J. E., Korsmeyer, S. J., Cleveland, J. L. Loss of bax alters tumor spectrum and tumor numbers in arf-deficient mice Cancer Research  2002 62:2184-2191  PMID:11929842
    • Fee, B. E., Doyle, C. A., Cleveland, J. L. A novel eyes absent 2 protein is expressed in the human eye Gene  2002 285:221-228  DOI:10.1016/s0378-1119(02)00404-3  PMID:12039049
    • Clark, S. W., Fee, B. E., Cleveland, J. L. Misexpression of the eyes absent family triggers the apoptotic program Journal of Biological Chemistry  2002 277:3560-3567  DOI:10.1074/jbc.M108410200  PMID:11700312
    • Braun, J. S., Sublett, J. E., Freyer, D., Mitchell, T. J., Cleveland, J. L., Tuomanen, E. I., Weber, J. R. Pneumococcal pneumolysin and h2o2 mediate brain cell apoptosis during meningitis Journal of Clinical Investigation  2002 109:19-27  DOI:10.1172/jci12035  PMID:11781347
    • Maclean, K. H., Cleveland, J. L., Porter, J. B. Cellular zinc content is a major determinant of iron chelator-induced apoptosis of thymocytes Blood  2001 98:3831-3839  DOI:10.1182/blood.V98.13.3831  PMID:11739193
    • Braun, J. S., Novak, R., Murray, P. J., Eischen, C. M., Susin, S. A., Kroemer, G., Halle, A., Weber, J. R., Tuomanen, E. I., Cleveland, J. L. Apoptosis-inducing factor mediates microglial and neuronal apoptosis caused by pneumococcus Journal of Infectious Diseases  2001 184:1300-1309  DOI:10.1086/324013  PMID:11679919
    • Eischen, C. M., Roussel, M. F., Korsmeyer, S. J., Cleveland, J. L. Bax loss impairs myc-induced apoptosis and circumvents the selection of p53 mutations during myc-mediated lymphomagenesis Molecular and Cellular Biology  2001 21:7653-7662  DOI:10.1128/mcb.21.22.7653-7662.2001  PMID:11604501
    • Eischen, C. M., Packham, G., Nip, J., Fee, B. E., Hiebert, S. W., Zambetti, G. P., Cleveland, J. L. Bcl-2 is an apoptotic target suppressed by both c-myc and e2f-1 Oncogene  2001 20:6983-6993  DOI:10.1038/sj.onc.1204892  PMID:11704823
    • Pestina, T. I., Cleveland, J. L., Yang, C. Y., Zambetti, G. P., Jackson, C. W. Mpl ligand prevents lethal myelosuppression by inhibiting p53-dependent apoptosis Blood  2001 98:2084-2090  DOI:10.1182/blood.V98.7.2084  PMID:11567994
    • Pendeville, H., Carpino, N., Marine, J. C., Takahashi, Y., Muller, M., Martial, J. A., Cleveland, J. L. The ornithine decarboxylase gene is essential for cell survival during early murine development Molecular and Cellular Biology  2001 21:6549-6558  DOI:10.1128/mcb.21.19.6549-6558.2001  PMID:11533243
    • Magnet, K. J., Orr, M. S., Cleveland, J. L., Rodriguez-Galindo, C., Yang, H., Yang, C. Y., Di, Y. M., Jain, P. T., Gewirtz, D. A. Suppression of c-myc expression and c-myc function in response to sustained DNA damage in mcf-7 breast tumor cells Biochemical Pharmacology  2001 62:593-602  DOI:10.1016/s0006-2952(01)00699-2  PMID:11585056
    • Drissi, R., Zindy, F., Roussel, M. F., Cleveland, J. L. C-myc-mediated regulation of telomerase activity is disabled in immortalized cells Journal of Biological Chemistry  2001 276:29994-30001  DOI:10.1074/jbc.M101899200  PMID:11402027
    • Eischen, C. M., Woo, D., Roussel, M. F., Cleveland, J. L. Apoptosis triggered by myc-induced suppression of bcl-x-l or bcl-2 is bypassed during lymphomagenesis Molecular and Cellular Biology  2001 21:5063-5070  DOI:10.1128/mcb.21.15.5063-5070.2001  PMID:11438662
    • Rodriguez-Galindo, C., Poquette, C. A., Daw, N. C., Tan, M., Meyer, W. H., Cleveland, J. L. Circulating concentrations of igf-i and icfbp-3 are not predictive of incidence or clinical behavior of pediatric osteosarcoma Medical and Pediatric Oncology  2001 36:605-611  DOI:10.1002/mpo.1137  PMID:11344491
    • Nip, J., Strom, D. K., Eischen, C. M., Cleveland, J. L., Zambetti, G. P., Hiebert, S. W. E2f-1 induces the stabilization of p53 but blocks p53-mediated transactivation Oncogene  2001 20:910-920  DOI:10.1038/sj.onc.1204171  PMID:11314026
    • Baudino, T. A., Cleveland, J. L. The max network gone mad Molecular and Cellular Biology  2001 21:691-702  DOI:10.1128/mcb.21.3.691-702.2001  PMID:11154257
    • Ruf, I. K., Rhyne, P. W., Yang, H., Borza, C. M., Hutt-Fletcher, L. M., Cleveland, J. L., Sample, J. T. Ebv regulates c-myc, apoptosis, and tumorigenicity in burkitt's lymphoma Current Topics in Microbiology and Immunology  2001 258:153-160  PMID:11443860
    • Wen, R. R., Wang, D. M., McKay, C., Bunting, K. D., Marine, J. C., Vanin, E. F., Zambetti, G. P., Korsmeyer, S. J., Ihle, J. N., Cleveland, J. L. Jak3 selectively regulates bax and bcl-2 expression to promote t-cell development Molecular and Cellular Biology  2001 21:678-689  DOI:10.1128/mcb.21.2.678-689.2001  PMID:11134353
    • Maclean, K., Yang, H., Cleveland, J. L. Serum suppresses myeloid progenitor apoptosis by regulating iron homeostasis Journal of Cellular Biochemistry  2001 82:171-186  DOI:10.1002/jcb.1111  PMID:11400174
    • Alt, J. R., Cleveland, J. L., Hannink, M., Diehl, J. A. Phosphorylation-dependent regulation of cyclin d1 nuclear export and cyclin d1-dependent cellular transformation Genes & Development  2000 14:3102-3114  DOI:10.1101/gad.854900  PMID:11124803  PMCID:PMC317128
    • Ruf, I. K., Rhyne, P. W., Yang, C. Y., Cleveland, J. L., Sample, J. T. Epstein-barr virus small rnas potentiate tumorigenicity of burkitt lymphoma cells independently of an effect on apoptosis Journal of Virology  2000 74:10223-10228  DOI:10.1128/jvi.74.21.10223-10228.2000  PMID:11024153
    • Inoue, K., Wen, R. R., Rehg, J. E., Adachi, M., Cleveland, J. L., Roussel, M. F., Sherr, C. J. Disruption of the arf transcriptional activator dmp1 facilitates cell immortalization, ras transformation, and tumorigenesis Genes & Development  2000 14:1797-1809  PMID:10898794  PMCID:PMC316790
    • Wang, D. M., Wen, R. R., Marine, J. C., Sangster, M. Y., Parganas, E., Hoffmeyer, A., Jackson, C. W., Cleveland, J. L., Ihle, J. N. Phospholipase Cγ2 is essential in the functions of B cell and several Fc receptors Immunity  2000 13:25-35  DOI:10.1016/s1074-7613(00)00005-4  PMID:10933392
    • Eischen, C. M., Weber, J. D., Roussel, M. F., Sherr, C. J., Cleveland, J. L. Disruption of the arf-mdm2-p53 tumor suppressor pathway in myc-induced lymphomagenesis Genes & Development  1999 13:2658-2669  DOI:10.1101/gad.13.20.2658  PMID:10541552  PMCID:PMC317106
    • Dai, H. Q., Kramer, D. L., Yang, C. Y., Murti, K. G., Porter, C. W., Cleveland, J. L. The polyamine oxidase inhibitor mdl-72,527 selectively induces apoptosis of transformed hematopoietic cells through lysosomotropic effects Cancer Research  1999 59:4944-4954  PMID:10519408
    • Ruf, I. K., Rhyne, P. W., Yang, H., Borza, C. M., Hutt-Fletcher, L. M., Cleveland, J. L., Sample, J. T. Epstein-barr virus regulates c-myc, apoptosis, and tumorigenicity in burkitt lymphoma Molecular and Cellular Biology  1999 19:1651-1660  PMID:10022853  PMCID:PMC83959
    • Braun, J. S., Novak, R., Herzog, K. H., Bodner, S. M., Cleveland, J. L., Tuomanen, E. I. Neuroprotection by a caspase inhibitor in acute bacterial meningitis Nature Medicine  1999 5:298-302  PMID:10086385
    • Florio, M., Hernandez, M. C., Yang, H., Shu, H. K., Cleveland, J. L., Israel, M. A. Id2 promotes apoptosis by a novel mechanism independent of dimerization to basic helix-loop-helix factors Molecular and Cellular Biology  1998 18:5435-5444  PMID:9710627  PMCID:PMC109128
    • Packham, G., White, E. L., Eischen, C. M., Yang, H., Parganas, E., Ihle, J. N., Grillot, D. A. M., Zambetti, G. P., Nunez, G., Cleveland, J. L. Selective regulation of bcl-xl by a jak kinase-dependent pathway is bypassed in murine hematopoietic malignancies Genes & Development  1998 12:2475-2487  DOI:10.1101/gad.12.16.2475  PMID:9716401  PMCID:PMC317092
    • Zindy, F., Eischen, C. M., Randle, D. H., Kamijo, T., Cleveland, J. L., Sherr, C. J., Roussel, M. F. Myc signaling via the arf tumor suppressor regulates p53-dependent apoptosis and immortalization Genes & Development  1998 12:2424-2433  DOI:10.1101/gad.12.15.2424  PMID:9694806  PMCID:PMC317045
    • Frazier, M. W., He, X. P., Wang, J. L., Gu, Z. M., Cleveland, J. L., Zambetti, G. P. Activation of c-myc gene expression by tumor-derived p53 mutants requires a discrete c-terminal domain Molecular and Cellular Biology  1998 18:3735-3743  PMID:9632756  PMCID:PMC108956
    • Quelle, F. W., Wang, J. L., Feng, J., Wang, D. M., Cleveland, J. L., Ihle, J. N., Zambetti, G. P. Cytokine rescue of p53-dependent apoptosis and cell cycle arrest is mediated by distinct jak kinase signaling pathways Genes & Development  1998 12:1099-1107  DOI:10.1101/gad.12.8.1099  PMID:9553040  PMCID:PMC316716
    • Strom, D. K., Cleveland, J. L., Chellappan, S., Nip, J., Hiebert, S. W. E2f-1 and e2f-3 are functionally distinct in their ability to promote myeloid cell cycle progression and block granulocyte differentiation Cell Growth & Differentiation  1998 9:59-69  PMID:9438389
    • Packham, G., Brimmell, M., Cleveland, J. L. Mammalian cells express two differently localized bag-1 isoforms generated by alternative translation initiation Biochemical Journal  1997 328 ( Pt 3):807-813  PMID:9396724  PMCID:PMC1218990
    • Brewer, J. W., Cleveland, J. L., Hendershot, L. M. A pathway distinct from the mammalian unfolded protein response regulates expression of endoplasmic reticulum chaperones in non-stressed cells EMBO Journal  1997 16:7207-7216  DOI:10.1093/emboj/16.23.7207  PMID:9384597  PMCID:PMC1170321
    • Zhan, Y., Cleveland, J. L., Stevens, J. L. A role for c-myc in chemically induced renal-cell death Molecular and Cellular Biology  1997 17:6755-6764  PMID:9343440  PMCID:PMC232530
    • Packham, G., Cleveland, J. L. Induction of ornithine decarboxylase by il-3 is mediated by sequential c-myc-independent and c-myc-dependent pathways Oncogene  1997 15:1219-1232  DOI:10.1038/sj.onc.1201273  PMID:9294616
    • Ikushima, S., Inukai, T., Inaba, T., Nimer, S. D., Cleveland, J. L., Look, A. T. Pivotal role for the nfil3/e4bp4 transcription factor in interleukin 3-mediated survival of pro-b lymphocytes Proceedings of the National Academy of Sciences of the United States of America  1997 94:2609-2614  DOI:10.1073/pnas.94.6.2609  PMID:9122243
    • Nip, J., Strom, D. K., Fee, B. E., Zambetti, G., Cleveland, J. L., Hiebert, S. W. E2f-1 cooperates with topoisomerase ii inhibition and DNA damage to selectively augment p53-independent apoptosis Molecular and Cellular Biology  1997 17:1049-1056  PMID:9032231  PMCID:PMC231829
    • Packham, G., Lahti, J. M., Fee, B. E., Gawn, J. M., CoustanSmith, E., Campana, D., Douglas, I., Kidd, V. J., Ghosh, S., Cleveland, J. L. Fas activates nf-kappa b and induces apoptosis in t-cell lines by signaling pathways distinct from those induced by tnf-alpha Cell Death and Differentiation  1997 4:130-139  DOI:10.1038/sj.cdd.4400217  PMID:16465219
    • Packham, G., Porter, C. W., Cleveland, J. L. C-myc induces apoptosis and cell cycle progression by separable, yet overlapping, pathways Oncogene  1996 13:461-469  PMID:8760287
    • Packham, G., Ashmun, R. A., Cleveland, J. L. Cytokines suppress apoptosis independent of increases in reactive oxygen levels Journal of Immunology  1996 156:2792-2800  PMID:8609398
    • Hiebert, S. W., Packham, G., Strom, D. K., Haffner, R., Oren, M., Zambetti, G., Cleveland, J. L. E2f-1/dp-1 induces p53 and overrides survival factors to trigger apoptosis Molecular and Cellular Biology  1995 15:6864-6874  PMID:8524253  PMCID:PMC230941
    • Ofir, R., Novick, I., Krup, M., Cleveland, J. L., Ihle, J. N., Weinstein, Y. Structural and functional analysis of the promoter of the murine v gamma 1.1 t cell receptor gene European Journal of Immunology  1995 25:3070-3078  DOI:10.1002/eji.1830251113  PMID:7489745
    • Katzav, S., Packham, G., Sutherland, M., Aroca, P., Santos, E., Cleveland, J. L. Vav and ras induce fibroblast transformation by overlapping signaling pathways, which require c-myc function Oncogene  1995 11:1079-1088  PMID:7566967
    • Packham, G., Cleveland, J. L. C-myc and apoptosis Biochimica et Biophysica Acta  1995 1242:11-28  DOI:10.1016/0304-419x(94)00015-t  PMID:7626652
    • Matsugi, T., Kreider, B. L., Delwel, R., Cleveland, J. L., Askew, D. S., Ihle, J. N. The evi-1 zinc-finger myeloid transforming protein binds to genomic fragments containing (gata)(n) sequences Oncogene  1995 11:191-198  PMID:7624127
    • Quelle, F. W., Shimoda, K., Thierfelder, W., Fischer, C., Kim, A., Ruben, S. M., Cleveland, J. L., Pierce, J. H., Keegan, A. D., Nelms, K., Paul, W. E., Ihle, J. N. Cloning of murine stat6 and human stat6, stat proteins that are tyrosine-phosphorylated in responses to il-4 and il-3 but are not required for mitogenesis Molecular and Cellular Biology  1995 15:3336-3343  PMID:7760829  PMCID:PMC230567
    • Cleveland, J. L., Ihle, J. N. Contenders in fasl/tnf death signaling Cell  1995 81:479-482  DOI:10.1016/0092-8674(95)90068-3  PMID:7758103
    • Weinstein, Y., Askew, D. S., Miura, O., Cleveland, J. L., Ihle, J. N. Regulation of t cell receptor gamma gene expression by cytokines in murine hematopoietic cells European Cytokine Network  1995 6:97-102  PMID:7578993
    • Conley, M. E., Fitch-Hilgenberg, M. E., Cleveland, J. L., Parolini, O., Rohrer, J. Screening of genomic DNA to identify mutations in the gene for bruton's tyrosine kinase Human Molecular Genetics  1994 3:1751-1756  DOI:10.1093/hmg/3.10.1751  PMID:7849697
    • Packham, G., Cleveland, J. L. Ornithine decarboxylase is a mediator of c-myc-induced apoptosis Molecular and Cellular Biology  1994 14:5741-5747  PMID:8065308  PMCID:PMC359099
    • Cleveland, J. L., Troppmair, J., Packham, G., Askew, D. S., Lloyd, P., Gonzalezgarcia, M., Nunez, G., Ihle, J. N., Rapp, U. R. V-raf suppresses apoptosis and promotes growth of interleukin-3-dependent myeloid cells Oncogene  1994 9:2217-2226  PMID:8036007
    • Roussel, M. F., Davis, J. N., Cleveland, J. L., Ghysdael, J., Hiebert, S. W. Dual control of myc expression through a single DNA-binding site targeted by ets family proteins and e2f-1 Oncogene  1994 9:405-415  PMID:8290253
    • Packham, G., Bello-Fernandez, C., Cleveland, J. L. Position and orientation independent transactivation by c-myc Cellular and Molecular Biology Research  1994 40:699-706  PMID:7787888
    • Askew, D. S., Ihle, J. N., Cleveland, J. L. Activation of apoptosis associated with enforced myc expression in myeloid progenitor cells is dominant to the suppression of apoptosis by interleukin-3 or erythropoietin Blood  1993 82:2079-2087  PMID:8400257
    • Armstrong, E., Korhonen, J., Silvennoinen, O., Cleveland, J. L., Lieberman, M. A., Alitalo, R. Expression of tie receptor tyrosine kinase in leukemia-cell lines Leukemia  1993 7:1585-1591  PMID:8412320
    • Silvennoinen, O., Witthuhn, B. A., Quelle, F. W., Cleveland, J. L., Yi, T. L., Ihle, J. N. Structure of the murine jak2 protein-tyrosine kinase and its role in interleukin-3 signal-transduction Proceedings of the National Academy of Sciences of the United States of America  1993 90:8429-8433  DOI:10.1073/pnas.90.18.8429  PMID:8378315
    • Bellofernandez, C., Packham, G., Cleveland, J. L. The ornithine decarboxylase gene is a transcriptional target of c-myc Proceedings of the National Academy of Sciences of the United States of America  1993 90:7804-7808  DOI:10.1073/pnas.90.16.7804  PMID:8356088
    • Miura, O., Cleveland, J. L., Ihle, J. N. Inactivation of erythropoietin receptor function by point mutations in a region having homology with other cytokine receptors Molecular and Cellular Biology  1993 13:1788-1795  PMID:8382775  PMCID:PMC359491
    • Reynolds, A. B., Herbert, L., Cleveland, J. L., Berg, S. T., Gaut, J. R. P120, a novel substrate of protein tyrosine kinase receptors and of p60v-src is related to cadherin-binding factors beta-catenin, plakoglobin and armadillo Oncogene  1992 7:2439-2445  PMID:1334250
    • Okuda, T., Cleveland, J. L., Downing, J. R. Pctaire-1 and pctaire-3, 2 members of a novel cdc2/cdc28-related protein-kinase gene family Oncogene  1992 7:2249-2258  PMID:1437147
    • Duyao, M. P., Kessler, D. J., Spicer, D. B., Bartholomew, C., Cleveland, J. L., Siekevitz, M., Sonenshein, G. E. Transactivation of the c-myc promoter by human t-cell leukemia-virus type-1 tax is mediated by nf-kappa-b Journal of Biological Chemistry  1992 267:16288-16291  PMID:1644814
    • Rock, C. O., Cleveland, J. L., Jackowski, S. Macrophage growth arrest by cyclic-amp defines a distinct checkpoint in the mid-g(1) stage of the cell-cycle and overrides constitutive c-myc expression Molecular and Cellular Biology  1992 12:2351-2358  PMID:1373814  PMCID:PMC364407
    • Yi, T. L., Cleveland, J. L., Ihle, J. N. Protein tyrosine phosphatase containing sh2 domains - characterization, preferential expression in hematopoietic-cells, and localization to human-chromosome 12p12-p13 Molecular and Cellular Biology  1992 12:836-846  PMID:1732748  PMCID:PMC364317
    • Yi, T. L., Cleveland, J. L., Ihle, J. N. Identification of novel protein tyrosine phosphatases of hematopoietic cells by polymerase chain reaction amplification Blood  1991 78:2222-2228  PMID:1932742
    • Askew, D. S., Ashmun, R. A., Simmons, B. C., Cleveland, J. L. Constitutive c-myc expression in an il-3-dependent myeloid cell-line suppresses cell-cycle arrest and accelerates apoptosis Oncogene  1991 6:1915-1922  PMID:1923514
    • Roussel, M. F., Cleveland, J. L., Shurtleff, S. A., Sherr, C. J. Myc rescue of a mutant csf-1 receptor impaired in mitogenic signaling Nature  1991 353:361-363  DOI:10.1038/353361a0  PMID:1833648
    • Katzav, S., Cleveland, J. L., Heslop, H. E., Pulido, D. Loss of the amino-terminal helix-loop-helix domain of the vav protooncogene activates its transforming potential Molecular and Cellular Biology  1991 11:1912-1920  PMID:2005887  PMCID:PMC359873
    • Beck, T. W., Brennscheidt, U., Sithanandam, G., Cleveland, J., Rapp, U. R. Molecular-organization of the human raf-1 promoter region Molecular and Cellular Biology  1990 10:3325-3333  PMID:1694010  PMCID:PMC360752
    • Principato, M., Cleveland, J. L., Rapp, U. R., Holmes, K. L., Pierce, J. H., Morse, H. C., Klinken, S. P. Transformation of murine bone-marrow cells with combined v-raf-v-myc oncogenes yields clonally related mature b-cells and macrophages Molecular and Cellular Biology  1990 10:3562-3568  PMID:2162474  PMCID:PMC360791
    • Heidecker, G., Huleihel, M., Cleveland, J. L., Kolch, W., Beck, T. W., Lloyd, P., Pawson, T., Rapp, U. R. Mutational activation of c-raf-1 and definition of the minimal transforming sequence Molecular and Cellular Biology  1990 10:2503-2512  PMID:2188091  PMCID:PMC360607
    • Storm, S. M., Cleveland, J. L., Rapp, U. R. Expression of raf family protooncogenes in normal mouse-tissues Oncogene  1990 5:345-351  PMID:1690378
    • Cleveland, J. L., Dean, M., Rosenberg, N., Wang, J. Y. J., Rapp, U. R. Tyrosine kinase oncogenes abrogate interleukin-3 dependence of murine myeloid cells through signaling pathways involving c-myc - conditional regulation of c-myc transcription by temperature-sensitive v-abl Molecular and Cellular Biology  1989 9:5685-5695  PMID:2555703  PMCID:PMC363740
    • Weinstein, Y., Morishita, K., Cleveland, J. L., Ihle, J. N. Interleukin-3 (il-3) induces transcription from nonrearranged t-cell receptor gamma loci in il-3-dependent cell-lines Journal of Experimental Medicine  1989 169:2059-2071  DOI:10.1084/jem.169.6.2059  PMID:2543731
    • Greil, R., Gattringer, C., Fasching, B., Cleveland, J., Thaler, J., Radaskiewicz, T., Gastl, G., Huber, C., Rapp, U., Huber, H. Abl oncogene expression in non-hodgkin lymphomas: Correlation to histological differentiation and clinical status International Journal of Cancer  1988 42:529-538  DOI:10.1002/ijc.2910420410  PMID:3049401
    • Farrar, W. L., Vinocour, M., Cleveland, J. L., Harelbellan, A. Regulation of ornithine decarboxylase activity by il-2 and cyclic-amp Journal of Immunology  1988 141:967-971  PMID:2840461
    • Cleveland, J. L., Dean, M., Wang, J. Y., Hedge, A. M., Ihle, J. N., Rapp, U. R. Abrogation of il-3 dependence of myeloid fdc-p1 cells by tyrosine kinase oncogenes is associated with induction of c-myc Current Topics in Microbiology and Immunology  1988 141:300-309  PMID:3265092
    • Horton, W. E., Jr., Cleveland, J., Rapp, U., Nemuth, G., Bolander, M., Doege, K., Yamada, Y., Hassell, J. R. An established rat cell line expressing chondrocyte properties Experimental Cell Research  1988 178:457-468  DOI:10.1016/0014-4827(88)90414-4  PMID:3049123
    • Dean, M., Cleveland, J., Kim, H. Y., Campisi, J., Levine, R. A., Ihle, J. N., Rapp, U. Deregulation of the c-myc and n-myc genes in transformed cells Current Topics in Microbiology and Immunology  1988 141:216-222  PMID:3215051
    • Principato, M., Klinken, S. P., Cleveland, J. L., Rapp, U. R., Holmes, K. L., Pierce, J. H., Morse, H. C. In vitro transformation of murine bone marrow cells with a v-raf/v-myc retrovirus yields clonally related mature b cells and macrophages Current Topics in Microbiology and Immunology  1988 141:31-41  PMID:3265093
    • Cleveland, J. L., Morse, H. C., Rapp, U. R. Myc oncogenes and tumor-induction ISI Atlas of Science-Biochemistry  1988 1:93-100
    • Troppmair, J., Huleihel, M., Cleveland, J., Mushinski, J. F., Kurie, J., Morse, H. C., Wax, J. S., Potter, M., Rapp, U. R. Plasmacytoma induction by j series of v-myc recombinant retroviruses: Evidence for the requirement of two (raf and myc) oncogenes for transformation Current Topics in Microbiology and Immunology  1988 141:110-114  PMID:3215044
    • Rapp, U. R., Heidecker, G., Huleihel, M., Cleveland, J. L., Choi, W. C., Pawson, T., Ihle, J. N., Anderson, W. B. Raf family serine/threonine protein kinases in mitogen signal transduction Cold Spring Harbor Symposia on Quantitative Biology  1988 53:173-184  PMID:2978288
    • Farrar, W. L., Evans, S. W., Rapp, U. R., Cleveland, J. L. Effects of antiproliferative cyclic-amp on interleukin 2-stimulated gene-expression Journal of Immunology  1987 139:2075-2080  PMID:3040863
    • Weinstein, Y., Cleveland, J. L., Askew, D. S., Rapp, U. R., Ihle, J. N. Insertion and truncation of c-myb by murine leukemia-virus in a myeloid cell-line derived from cultures of normal hematopoietic-cells Journal of Virology  1987 61:2339-2343  PMID:2884332  PMCID:PMC283705
    • Cleveland, J. L., Rapp, U. R., Farrar, W. L. Role of c-myc and other genes in interleukin-2 regulated ct6 lymphocytes-t and their malignant variants Journal of Immunology  1987 138:3495-3504  PMID:3106484
    • Dean, M., Cleveland, J. L., Rapp, U. R., Ihle, J. N. Role of myc in the abrogation of il3 dependence of myeloid fdc-p1 cells Oncogene Research  1987 1:279-296  PMID:2453016
    • Morse, H. C., Hartley, J. W., Fredrickson, T. N., Yetter, R. A., Majumdar, C., Cleveland, J. L., Rapp, U. R. Recombinant murine retroviruses containing avian v-myc induce a wide spectrum of neoplasms in newborn mice Proceedings of the National Academy of Sciences of the United States of America  1986 83:6868-6872  DOI:10.1073/pnas.83.18.6868  PMID:3018749
    • Huleihel, M., Goldsborough, M., Cleveland, J., Gunnell, M., Bonner, T., Rapp, U. R. Characterization of murine a-raf, a new oncogene related to the v-raf oncogene Molecular and Cellular Biology  1986 6:2655-2662  PMID:3491291  PMCID:PMC367822
    • Huebner, K., Arrushdi, A., Griffin, C. A., Isobe, M., Kozak, C., Emanuel, B. S., Nagarajan, L., Cleveland, J. L., Bonner, T. I., Goldsborough, M. D., Croce, C. M., Rapp, U. Actively transcribed genes in the raf oncogene group, located on the x-chromosome in mouse and human Proceedings of the National Academy of Sciences of the United States of America  1986 83:3934-3938  DOI:10.1073/pnas.83.11.3934  PMID:3520560
    • Farrar, W. L., Cleveland, J. L., Beckner, S. K., Bonvini, E., Evans, S. W. Biochemical and molecular events associated with interleukin 2 regulation of lymphocyte proliferation Immunological Reviews  1986 92:49-65  DOI:10.1111/j.1600-065X.1986.tb01493.x  PMID:3091482
    • Cleveland, J. L., Jansen, H. W., Bister, K., Fredrickson, T. N., Morse, H. C., Ihle, J. N., Rapp, U. R. Interaction between Raf and Myc oncogenes in transformation in vivo and in vitro Journal of Cellular Biochemistry  1986 30:195-218  DOI:10.1002/jcb.240300303  PMID:3084503
    • Cleveland, J. L., Weinstein, Y., Ihle, J. N., Askew, D. S., Rapp, U. R. Transformation and insertional mutagenesis in vitro of primary hematopoietic stem cell cultures Current Topics in Microbiology and Immunology  1986 132:44-54  PMID:3024923
    • Morse, H. C., 3rd, Hartley, J. W., Fredrickson, T. N., Yetter, R. A., Cleveland, J. L., Majumdar, C., Rapp, U. R. Tumors of newborn nfs/n mice infected with murine retroviruses containing avian v-myc Current Topics in Microbiology and Immunology  1986 132:17-22  PMID:3024912
    • Rapp, U. R., Cleveland, J. L., Brightman, K., Scott, A., Ihle, J. N. Abrogation of IL-3 and IL-2 dependence by recombinant murine retroviruses expressing v-myc oncogenes Nature  1985 317:434-438  DOI:10.1038/317434a0  PMID:3930972
    • Rapp, U. R., Cleveland, J. L., Fredrickson, T. N., Holmes, K. L., Morse, H. C., Jansen, H. W., Patschinsky, T., Bister, K. Rapid induction of hemopoietic neoplasms in newborn mice by a raf(mil)/myc recombinant murine retrovirus Journal of Virology  1985 55:23-33  PMID:4009794  PMCID:PMC254893
    • Blasi, E., Mathieson, B. J., Varesio, L., Cleveland, J. L., Borchert, P. A., Rapp, U. R. Selective immortalization of murine macrophages from fresh bone-marrow by a raf/myc recombinant murine retrovirus Nature  1985 318:667-670  DOI:10.1038/318667a0  PMID:4079980
  • thesis

    • Characterization of gene expression from the EcoRI F region of the herpes simplex virus type I genome 1985

featured in

  • Mixing Basic and Applied Research: An Interview with John Cleveland  Newsletter
  • Scripps Florida Scientists Share $3.85 Million NIH Grant to Develop New Class of Cancer Therapies  News Release
  • Scripps Research Cancer Biology Department Awarded More than $8 Million in New Research Grants  News Release
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Affiliation

head of

  • Cancer Biology
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Background

education and training

  • Ph.D., Wayne State University , School of Medicine 1985 -
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Contact

full name

  • John Lamoine Cleveland

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