recent publications
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academic article
- Li, H., Saucedo-Cuevas, L., Yuan, L., Ross, D., Johansen, A., Sands, D., Stanley, V., Guemez-Gamboa, A., Gregor, A., Evans, T., Chen, S., Tan, L., et al. Zika virus protease cleavage of host protein septin-2 mediates mitotic defects in neural progenitors Neuron 2019 101:1089-1098 DOI:10.1016/j.neuron.2019.01.010 PMID:30713029
- Chen, S. Screening-based chemical approaches to unravel stem cell biology Stem Cell Reports 2018 11:1312-1323 DOI:10.1016/j.stemcr.2018.11.012 PMID:30540959 PMCID:PMC6294285
- Zhou, T., Kim, T. W., Chong, C. N., Tan, L., Amin, S., Badieyan, Z. S., Mukherjee, S., Ghazizadeh, Z., Zeng, H., Guo, M., Crespo, M., Zhang, T., et al. A hPSC-based platform to discover gene-environment interactions that impact human β-cell and dopamine neuron survival Nature Communications 2018 9 DOI:10.1038/s41467-018-07201-1 PMID:30446643 PMCID:PMC6240096
- Scaglione, A., Patzig, J., Liang, J. L., Frawley, R., Bok, J., Mela, A., Yattah, C., Zhang, J., Teo, S., Zhou, T., Chen, S., Bernstein, E., et al. PRMT5-mediated regulation of developmental myelination Nature Communications 2018 9 DOI:10.1038/s41467-018-04863-9 PMID:30026560 PMCID:PMC6053423
- Amin, S., Cook, B., Zhou, T., Ghazizadeh, Z., Lis, R., Zhang, T., Khalaj, M., Crespo, M., Perera, M., Xiang, J. Z., Zhu, Z. R., Tomishima, M., et al. Discovery of a drug candidate for GLIS3-associated diabetes Nature Communications 2018 9 DOI:10.1038/s41467-018-04918-x PMID:29992946 PMCID:PMC6041295
- Mukherjee, S., Zhang, T., Lacko, L. A., Tan, L., Xiang, J. Z., Butler, J. M., Chen, S. Derivation and characterization of a UCP1 reporter human ES cell line Stem Cell Research 2018 30:12-21 DOI:10.1016/j.scr.2018.04.007 PMID:29777802
- Robinson, C. L., Chong, A. C. N., Ashbrook, A. W., Jeng, G., Jin, J., Chen, H., Tang, E. I., Martin, L. A., Kim, R. S., Kenyon, R. M., Do, E., Luna, J. M., et al. Male germ cells support long-term propagation of Zika virus Nature Communications 2018 9 DOI:10.1038/s41467-018-04444-w PMID:29844387 PMCID:PMC5974187
- Tchieu, J., Zimmer, B., Fattahi, F., Amin, S., Zeltner, N., Chen, S., Studer, L. A modular platform for differentiation of human PSCs into all major ectodermal lineages Cell Stem Cell 2017 21:399-410 DOI:10.1016/j.stem.2017.08.015 PMID:28886367 PMCID:PMC5737635
- Ghazizadeh, Z., Kao, D. I., Amin, S., Cook, B., Rao, S., Zhou, T., Zhang, T., Xiang, Z., Kenyon, R., Kaymakcalan, O., Liu, C., Evans, T., et al. ROCKII inhibition promotes the maturation of human pancreatic beta-like cells Nature Communications 2017 8 DOI:10.1038/s41467-017-00129-y PMID:28824164 PMCID:PMC5563509
- Walsh, L. A., Alvarez, M. J., Sabio, E. Y., Reyngold, M., Makarov, V., Mukherjee, S., Lee, K. W., Desrichard, A., Turcan, S., Dalin, M. G., Rajasekhar, V. K., Chen, S., et al. An integrated systems biology approach identifies TRIM25 as a key determinant of breast cancer metastasis Cell Reports 2017 20:1623-1640 DOI:10.1016/j.celrep.2017.07.052 PMID:28813674
- Zhou, T., Tan, L., Cederquist, G. Y., Fan, Y., Hartley, B. J., Mukherjee, S., Tomishima, M., Brennand, K. J., Zhang, Q., Schwartz, R. E., Evans, T., Studer, L., et al. High-content screening in hPSC-neural progenitors identifies drug candidates that inhibit Zika virus infection in fetal-like organoids and adult brain Cell Stem Cell 2017 21:274-283 DOI:10.1016/j.stem.2017.06.017 PMID:28736217 PMCID:PMC5553280
- Crespo, M., Vilar, E., Tsai, S. Y., Chang, K., Amin, S., Srinivasan, T., Zhang, T., Pipalia, N. H., Chen, H. J., Witherspoon, M., Gordillo, M., Xiang, J. Z., et al. Colonic organoids derived from human induced pluripotent stem cells for modeling colorectal cancer and drug testing Nature Medicine 2017 23:878-884 DOI:10.1038/nm.4355 PMID:28628110
- Ghazizadeh, Z., Rassouli, H., Fonoudi, H., Alikhani, M., Talkhabi, M., Darbandi-Azar, A., Chen, S., Baharvand, H., Aghdami, N., Salekdeh, G. H. Transient activation of reprogramming transcription factors using protein transduction facilitates conversion of human fibroblasts toward cardiomyocyte-like cells Molecular Biotechnology 2017 59:207-220 DOI:10.1007/s12033-017-0007-x PMID:28509990
- Guo, M., Zhang, T., Dong, X., Xiang, J. Z., Lei, M., Evans, T., Graumann, J., Chen, S. Using hESCs to probe the interaction of the diabetes-associated genes CDKAL1 and MT1E Cell Reports 2017 19:1512-1521 DOI:10.1016/j.celrep.2017.04.070 PMID:28538172
- Shi, Z., Lee, K., Yang, D., Amin, S., Verma, N., Li, Q. V., Zhu, Z., Soh, C. L., Kumar, R., Evans, T., Chen, S., Huangfu, D. W. Genome editing in hPSCs reveals GATA6 haploinsufficiency and a genetic interaction with GATA4 in human pancreatic development Cell Stem Cell 2017 20:675-688 DOI:10.1016/j.stem.2017.01.001 PMID:28196600 PMCID:PMC5419850
- Liang, H., Zheng, Q. L., Fang, P., Zhang, J., Zhang, T., Liu, W., Guo, M., Robinson, C. L., Chen, S., Chen, X. P., Chen, F. P., Zeng, H. Targeting the PI3K/AKT pathway via GLI1 inhibition enhanced the drug sensitivity of acute myeloid leukemia cells Scientific Reports 2017 7 DOI:10.1038/srep40361 PMID:28098170 PMCID:PMC5241777
- Zeng, H., Guo, M., Zhou, T., Tan, L., Chong, C. N., Zhang, T., Dong, X., Xiang, J. Z., Yu, A. S., Yue, L., Qi, Q., Evans, T., et al. An isogenic human ESC platform for functional evaluation of genome-wide-association-study-identified diabetes genes and drug discovery Cell Stem Cell 2016 19:326-340 DOI:10.1016/j.stem.2016.07.002 PMID:27524441
- Chen, H. J., Wei, Z., Sun, J., Bhattacharya, A., Savage, D. J., Serda, R., Mackeyev, Y., Curley, S. A., Bu, P., Wang, L., Chen, S., Cohen-Gould, L., et al. A recellularized human colon model identifies cancer driver genes Nature Biotechnology 2016 34:845-851 DOI:10.1038/nbt.3586 PMID:27398792 PMCID:PMC4980997
- Li, G., Wu, B., Ward, M. G., Chong, A. C. N., Mukherjee, S., Chen, S., Hao, M. Multifunctional in vivo imaging of pancreatic islets during diabetes development Journal of Cell Science 2016 129:2865-2875 DOI:10.1242/jcs.190843 PMID:27270669 PMCID:PMC4958299
- Feng, L., Cook, B., Tsai, S. Y., Zhou, T., LaFlamme, B., Evans, T., Chen, S. Discovery of a small-molecule BMP sensitizer for human embryonic stem cell differentiation Cell Reports 2016 15:2063-2075 DOI:10.1016/j.celrep.2016.04.066 PMID:27210748 PMCID:PMC4889468
- Simsek, S., Zhou, T., Robinson, C. L., Tsai, S. Y., Crespo, M., Amin, S., Lin, X., Hon, J., Evans, T., Chen, S. Modeling cystic fibrosis using pluripotent stem cell-derived human pancreatic ductal epithelial cells Stem Cells Translational Medicine 2016 5:572-579 DOI:10.5966/sctm.2015-0276 PMID:27034411 PMCID:PMC4835252
- Fattahi, F., Steinbeck, J. A., Kriks, S., Tchieu, J., Zimmer, B., Kishinevsky, S., Zeltner, N., Mica, Y., El-Nachef, W., Zhao, H., de Stanchina, E., Gershon, M. D., et al. Deriving human ENS lineages for cell therapy and drug discovery in Hirschsprung disease Nature 2016 531:105-109 DOI:10.1038/nature16951 PMID:26863197 PMCID:PMC4846424
- Song, W., Tung, C. K., Lu, Y. C., Pardo, Y., Wu, M., Das, M., Kao, D. I., Chen, S., Ma, M. Dynamic self-organization of microwell-aggregated cellular mixtures Soft Matter 2016 12:5739-5746 DOI:10.1039/c6sm00456c PMID:27275624
- Tsai, S. Y., Maass, K., Lu, J., Fishman, G. I., Chen, S., Evans, T. Efficient generation of cardiac Purkinje cells from ESCs by activating cAMP signaling Stem Cell Reports 2015 4:1089-1102 DOI:10.1016/j.stemcr.2015.04.015 PMID:26028533 PMCID:PMC4471825
- Kao, D. I., Lacko, L. A., Ding, B. S., Huang, C., Phung, K., Gu, G., Rafii, S., Stuhlmann, H., Chen, S. Endothelial cells control pancreatic cell fate at defined stages through EGFL7 signaling Stem Cell Reports 2015 4:181-189 DOI:10.1016/j.stemcr.2014.12.008 PMID:25601205 PMCID:PMC4325230
- Song, W., An, D., Kao, D. I., Lu, Y. C., Da, G., Chen, S., Ma, M. Nanofibrous microposts and microwells of controlled shapes and their hybridization with hydrogels for cell encapsulation ACS Applied Materials & Interfaces 2014 6:7038-7044 DOI:10.1021/am502046h PMID:24806031 PMCID:PMC4039346
- Kao, D. I., Chen, S. Pluripotent stem cell-derived pancreatic β-cells: potential for regenerative medicine in diabetes Regenerative Medicine 2012 7:583-593 DOI:10.2217/rme.12.27 PMID:22817630
- Ye, J., Chen, S., Maniatis, T. Cardiac glycosides are potent inhibitors of interferon-beta gene expression Nature Chemical Biology 2011 7:25-33 DOI:10.1038/nchembio.476 PMID:21076398 PMCID:PMC3076628
- Maehr, R., Chen, S., Snitow, M., Ludwig, T., Yagasaki, L., Goland, R., Leibel, R. L., Melton, D. A. Generation of pluripotent stem cells from patients with type 1 diabetes Proceedings of the National Academy of Sciences of the United States of America 2009 106:15768-15773 DOI:10.1073/pnas.0906894106
- Borowiak, M., Maehr, R., Chen, S., Chen, A. E., Tang, W., Fox, J. L., Schreiber, S. L., Melton, D. A. Small molecules efficiently direct endodermal differentiation of mouse and human embryonic stem cells Cell Stem Cell 2009 4:348-358 DOI:10.1016/j.stem.2009.01.014 PMID:19341624
- Chen, S., Borowiak, M., Fox, J. L., Maehr, R., Osafune, K., Davidow, L., Lam, K., Peng, L. F., Schreiber, S. L., Rubin, L. L., Melton, D. A small molecule that directs differentiation of human ESCs into the pancreatic lineage Nature Chemical Biology 2009 5:258-265 DOI:10.1038/nchembio.154 PMID:19287398
- Huangfu, D., Osafune, K., Maehr, R., Guo, W., Eijkelenboom, A., Chen, S., Muhlestein, W., Melton, D. A. Induction of pluripotent stem cells from primary human fibroblasts with only Oct4 and Sox2 Nature Biotechnology 2008 26:1269-1275 DOI:10.1038/nbt.1502 PMID:18849973
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Qyang, Y., Martin-Puig, S., Chiravuri, M., Chen, S., Xu, H., Bu, L., Jiang, X., Lin, L., Granger, A., Moretti, A., Caron, L., Wu, X., et al.
The renewal and differentiation of Isl1+ cardiovascular progenitors are controlled by a Wnt/beta-catenin pathway
Cell Stem Cell
2007
1:165-179
DOI:10.1016/j.stem.2007.05.018
PMID:18371348
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Chen, S., Takanashi, S. C., Zhang, Q. S., Xiong, W., Zhu, S. T., Peters, E. C., Ding, S., Schultz, P. G.
Reversine increases the plasticity of lineage-committed mammalian cells
Proceedings of the National Academy of Sciences of the United States of America
2007
104:10482-10487
DOI:10.1073/pnas.0704360104
PMID:17566101
PMCID:PMC1965539
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Liu, W. S., Brock, A., Chen, S., Chen, S., Schultz, P. G.
Genetic incorporation of unnatural amino acids into proteins in mammalian cells
Nature Methods
2007
4:239-244
DOI:10.1038/nmeth1016
PMID:17322890
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Chen, S., Do, J. T., Zhang, Q. S., Yao, S. Y., Yan, F., Peters, E. C., Scholer, H. R., Schultz, P. G., Ding, S.
Self-renewal of embryonic stem cells by a small molecule
Proceedings of the National Academy of Sciences of the United States of America
2006
103:17266-17271
DOI:10.1073/pnas.0608156103
PMID:17088537
PMCID:PMC1859921
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Yao, S., Chen, S., Clark, J., Hao, E., Beattie, G. M., Hayek, A., Ding, S.
Long-term self-renewal and directed differentiation of human embryonic stem cells in chemically defined conditions
Proceedings of the National Academy of Sciences of the United States of America
2006
103:6907-6912
DOI:10.1073/pnas.0602280103
PMID:16632596
PMCID:PMC1458992
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Chen, S., Hilcove, S., Ding, S.
Exploring stem cell biology with small molecules
Molecular Biosystems
2006
2:18-24
DOI:10.1039/b512000b
PMID:16880919
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Chen, S., Zhang, Q. S., Wu, X., Schultz, P. G., Ding, S.
Dedifferentiation of lineage-committed cells by a small molecule
Journal of the American Chemical Society
2004
126:410-411
DOI:10.1021/ja037390k
PMID:14719906
- Chen, Z., Tong, Y., Chen, S., Li, Y. M., Chen, Y., Zhao, Y. F., Wang, J. Orientation of the peptide formation of N-phosphoryl amino acids in solution Chinese Science Bulletin 2002 47:1866-1870 DOI:10.1360/02tb9408
- Chen, Z., Chen, S., Chen, Y., Li, Y. M., Chen, J., Zhao, Y. F. Negative-ion electrospray ionization tandem mass spectrometry of N-phosphoryl amino acids and dipeptides Rapid Communications in Mass Spectrometry 2002 16:790-796 DOI:10.1002/rcm.631 PMID:11921264
- Chen, S., Li, Y. M., Luo, S. Z., Zhao, G., Tan, B., Zhao, Y. F. The study of phosphoramidite as O-phosphitylation agent and its reactivity Phosphorus Sulfur and Silicon and the Related Elements 2000 164:277-291 DOI:10.1080/10426500008045253
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chapter
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Chen, S., Ding, S.
GSK-3 and stem cells
Glycogen Synthase Kinase 3 (GSK-3) and Its Inhibitors: Drug Discovery and Development.
155-172.
2006
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