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Chen, Shuibing
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Chen, Shuibing

Graduate Student
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Positions

  • 2011 - Faculty Member, Weill Cornell Medical College , Cornell University
  • 2007 - 2010 Postdoctoral Research Associate, Harvard Stem Cell Institute (HSCI)

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Publications

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    • Li, H., Saucedo-Cuevas, L., Yuan, L., Ross, D., Johansen, A., Sands, D., Stanley, V., Guemez-Gamboa, A., Gregor, A., Evans, T., Chen, S., Tan, L., et al. Zika virus protease cleavage of host protein septin-2 mediates mitotic defects in neural progenitors Neuron  2019 101:1089-1098  DOI:10.1016/j.neuron.2019.01.010  PMID:30713029
    • Chen, S. Screening-based chemical approaches to unravel stem cell biology Stem Cell Reports  2018 11:1312-1323  DOI:10.1016/j.stemcr.2018.11.012  PMID:30540959  PMCID:PMC6294285
    • Zhou, T., Kim, T. W., Chong, C. N., Tan, L., Amin, S., Badieyan, Z. S., Mukherjee, S., Ghazizadeh, Z., Zeng, H., Guo, M., Crespo, M., Zhang, T., et al. A hPSC-based platform to discover gene-environment interactions that impact human β-cell and dopamine neuron survival Nature Communications  2018 9  DOI:10.1038/s41467-018-07201-1  PMID:30446643  PMCID:PMC6240096
    • Scaglione, A., Patzig, J., Liang, J. L., Frawley, R., Bok, J., Mela, A., Yattah, C., Zhang, J., Teo, S., Zhou, T., Chen, S., Bernstein, E., et al. PRMT5-mediated regulation of developmental myelination Nature Communications  2018 9  DOI:10.1038/s41467-018-04863-9  PMID:30026560  PMCID:PMC6053423
    • Amin, S., Cook, B., Zhou, T., Ghazizadeh, Z., Lis, R., Zhang, T., Khalaj, M., Crespo, M., Perera, M., Xiang, J. Z., Zhu, Z. R., Tomishima, M., et al. Discovery of a drug candidate for GLIS3-associated diabetes Nature Communications  2018 9  DOI:10.1038/s41467-018-04918-x  PMID:29992946  PMCID:PMC6041295
    • Mukherjee, S., Zhang, T., Lacko, L. A., Tan, L., Xiang, J. Z., Butler, J. M., Chen, S. Derivation and characterization of a UCP1 reporter human ES cell line Stem Cell Research  2018 30:12-21  DOI:10.1016/j.scr.2018.04.007  PMID:29777802
    • Robinson, C. L., Chong, A. C. N., Ashbrook, A. W., Jeng, G., Jin, J., Chen, H., Tang, E. I., Martin, L. A., Kim, R. S., Kenyon, R. M., Do, E., Luna, J. M., et al. Male germ cells support long-term propagation of Zika virus Nature Communications  2018 9  DOI:10.1038/s41467-018-04444-w  PMID:29844387  PMCID:PMC5974187
    • Tchieu, J., Zimmer, B., Fattahi, F., Amin, S., Zeltner, N., Chen, S., Studer, L. A modular platform for differentiation of human PSCs into all major ectodermal lineages Cell Stem Cell  2017 21:399-410  DOI:10.1016/j.stem.2017.08.015  PMID:28886367  PMCID:PMC5737635
    • Ghazizadeh, Z., Kao, D. I., Amin, S., Cook, B., Rao, S., Zhou, T., Zhang, T., Xiang, Z., Kenyon, R., Kaymakcalan, O., Liu, C., Evans, T., et al. ROCKII inhibition promotes the maturation of human pancreatic beta-like cells Nature Communications  2017 8  DOI:10.1038/s41467-017-00129-y  PMID:28824164  PMCID:PMC5563509
    • Walsh, L. A., Alvarez, M. J., Sabio, E. Y., Reyngold, M., Makarov, V., Mukherjee, S., Lee, K. W., Desrichard, A., Turcan, S., Dalin, M. G., Rajasekhar, V. K., Chen, S., et al. An integrated systems biology approach identifies TRIM25 as a key determinant of breast cancer metastasis Cell Reports  2017 20:1623-1640  DOI:10.1016/j.celrep.2017.07.052  PMID:28813674
    • Zhou, T., Tan, L., Cederquist, G. Y., Fan, Y., Hartley, B. J., Mukherjee, S., Tomishima, M., Brennand, K. J., Zhang, Q., Schwartz, R. E., Evans, T., Studer, L., et al. High-content screening in hPSC-neural progenitors identifies drug candidates that inhibit Zika virus infection in fetal-like organoids and adult brain Cell Stem Cell  2017 21:274-283  DOI:10.1016/j.stem.2017.06.017  PMID:28736217  PMCID:PMC5553280
    • Crespo, M., Vilar, E., Tsai, S. Y., Chang, K., Amin, S., Srinivasan, T., Zhang, T., Pipalia, N. H., Chen, H. J., Witherspoon, M., Gordillo, M., Xiang, J. Z., et al. Colonic organoids derived from human induced pluripotent stem cells for modeling colorectal cancer and drug testing Nature Medicine  2017 23:878-884  DOI:10.1038/nm.4355  PMID:28628110
    • Ghazizadeh, Z., Rassouli, H., Fonoudi, H., Alikhani, M., Talkhabi, M., Darbandi-Azar, A., Chen, S., Baharvand, H., Aghdami, N., Salekdeh, G. H. Transient activation of reprogramming transcription factors using protein transduction facilitates conversion of human fibroblasts toward cardiomyocyte-like cells Molecular Biotechnology  2017 59:207-220  DOI:10.1007/s12033-017-0007-x  PMID:28509990
    • Guo, M., Zhang, T., Dong, X., Xiang, J. Z., Lei, M., Evans, T., Graumann, J., Chen, S. Using hESCs to probe the interaction of the diabetes-associated genes CDKAL1 and MT1E Cell Reports  2017 19:1512-1521  DOI:10.1016/j.celrep.2017.04.070  PMID:28538172
    • Shi, Z., Lee, K., Yang, D., Amin, S., Verma, N., Li, Q. V., Zhu, Z., Soh, C. L., Kumar, R., Evans, T., Chen, S., Huangfu, D. W. Genome editing in hPSCs reveals GATA6 haploinsufficiency and a genetic interaction with GATA4 in human pancreatic development Cell Stem Cell  2017 20:675-688  DOI:10.1016/j.stem.2017.01.001  PMID:28196600  PMCID:PMC5419850
    • Liang, H., Zheng, Q. L., Fang, P., Zhang, J., Zhang, T., Liu, W., Guo, M., Robinson, C. L., Chen, S., Chen, X. P., Chen, F. P., Zeng, H. Targeting the PI3K/AKT pathway via GLI1 inhibition enhanced the drug sensitivity of acute myeloid leukemia cells Scientific Reports  2017 7  DOI:10.1038/srep40361  PMID:28098170  PMCID:PMC5241777
    • Zeng, H., Guo, M., Zhou, T., Tan, L., Chong, C. N., Zhang, T., Dong, X., Xiang, J. Z., Yu, A. S., Yue, L., Qi, Q., Evans, T., et al. An isogenic human ESC platform for functional evaluation of genome-wide-association-study-identified diabetes genes and drug discovery Cell Stem Cell  2016 19:326-340  DOI:10.1016/j.stem.2016.07.002  PMID:27524441
    • Chen, H. J., Wei, Z., Sun, J., Bhattacharya, A., Savage, D. J., Serda, R., Mackeyev, Y., Curley, S. A., Bu, P., Wang, L., Chen, S., Cohen-Gould, L., et al. A recellularized human colon model identifies cancer driver genes Nature Biotechnology  2016 34:845-851  DOI:10.1038/nbt.3586  PMID:27398792  PMCID:PMC4980997
    • Li, G., Wu, B., Ward, M. G., Chong, A. C. N., Mukherjee, S., Chen, S., Hao, M. Multifunctional in vivo imaging of pancreatic islets during diabetes development Journal of Cell Science  2016 129:2865-2875  DOI:10.1242/jcs.190843  PMID:27270669  PMCID:PMC4958299
    • Feng, L., Cook, B., Tsai, S. Y., Zhou, T., LaFlamme, B., Evans, T., Chen, S. Discovery of a small-molecule BMP sensitizer for human embryonic stem cell differentiation Cell Reports  2016 15:2063-2075  DOI:10.1016/j.celrep.2016.04.066  PMID:27210748  PMCID:PMC4889468
    • Simsek, S., Zhou, T., Robinson, C. L., Tsai, S. Y., Crespo, M., Amin, S., Lin, X., Hon, J., Evans, T., Chen, S. Modeling cystic fibrosis using pluripotent stem cell-derived human pancreatic ductal epithelial cells Stem Cells Translational Medicine  2016 5:572-579  DOI:10.5966/sctm.2015-0276  PMID:27034411  PMCID:PMC4835252
    • Fattahi, F., Steinbeck, J. A., Kriks, S., Tchieu, J., Zimmer, B., Kishinevsky, S., Zeltner, N., Mica, Y., El-Nachef, W., Zhao, H., de Stanchina, E., Gershon, M. D., et al. Deriving human ENS lineages for cell therapy and drug discovery in Hirschsprung disease Nature  2016 531:105-109  DOI:10.1038/nature16951  PMID:26863197  PMCID:PMC4846424
    • Song, W., Tung, C. K., Lu, Y. C., Pardo, Y., Wu, M., Das, M., Kao, D. I., Chen, S., Ma, M. Dynamic self-organization of microwell-aggregated cellular mixtures Soft Matter  2016 12:5739-5746  DOI:10.1039/c6sm00456c  PMID:27275624
    • Tsai, S. Y., Maass, K., Lu, J., Fishman, G. I., Chen, S., Evans, T. Efficient generation of cardiac Purkinje cells from ESCs by activating cAMP signaling Stem Cell Reports  2015 4:1089-1102  DOI:10.1016/j.stemcr.2015.04.015  PMID:26028533  PMCID:PMC4471825
    • Kao, D. I., Lacko, L. A., Ding, B. S., Huang, C., Phung, K., Gu, G., Rafii, S., Stuhlmann, H., Chen, S. Endothelial cells control pancreatic cell fate at defined stages through EGFL7 signaling Stem Cell Reports  2015 4:181-189  DOI:10.1016/j.stemcr.2014.12.008  PMID:25601205  PMCID:PMC4325230
    • Song, W., An, D., Kao, D. I., Lu, Y. C., Da, G., Chen, S., Ma, M. Nanofibrous microposts and microwells of controlled shapes and their hybridization with hydrogels for cell encapsulation ACS Applied Materials & Interfaces  2014 6:7038-7044  DOI:10.1021/am502046h  PMID:24806031  PMCID:PMC4039346
    • Kao, D. I., Chen, S. Pluripotent stem cell-derived pancreatic β-cells: potential for regenerative medicine in diabetes Regenerative Medicine  2012 7:583-593  DOI:10.2217/rme.12.27  PMID:22817630
    • Ye, J., Chen, S., Maniatis, T. Cardiac glycosides are potent inhibitors of interferon-beta gene expression Nature Chemical Biology  2011 7:25-33  DOI:10.1038/nchembio.476  PMID:21076398  PMCID:PMC3076628
    • Maehr, R., Chen, S., Snitow, M., Ludwig, T., Yagasaki, L., Goland, R., Leibel, R. L., Melton, D. A. Generation of pluripotent stem cells from patients with type 1 diabetes Proceedings of the National Academy of Sciences of the United States of America  2009 106:15768-15773  DOI:10.1073/pnas.0906894106
    • Borowiak, M., Maehr, R., Chen, S., Chen, A. E., Tang, W., Fox, J. L., Schreiber, S. L., Melton, D. A. Small molecules efficiently direct endodermal differentiation of mouse and human embryonic stem cells Cell Stem Cell  2009 4:348-358  DOI:10.1016/j.stem.2009.01.014  PMID:19341624
    • Chen, S., Borowiak, M., Fox, J. L., Maehr, R., Osafune, K., Davidow, L., Lam, K., Peng, L. F., Schreiber, S. L., Rubin, L. L., Melton, D. A small molecule that directs differentiation of human ESCs into the pancreatic lineage Nature Chemical Biology  2009 5:258-265  DOI:10.1038/nchembio.154  PMID:19287398
    • Huangfu, D., Osafune, K., Maehr, R., Guo, W., Eijkelenboom, A., Chen, S., Muhlestein, W., Melton, D. A. Induction of pluripotent stem cells from primary human fibroblasts with only Oct4 and Sox2 Nature Biotechnology  2008 26:1269-1275  DOI:10.1038/nbt.1502  PMID:18849973
    • degree-related publication Qyang, Y., Martin-Puig, S., Chiravuri, M., Chen, S., Xu, H., Bu, L., Jiang, X., Lin, L., Granger, A., Moretti, A., Caron, L., Wu, X., et al. The renewal and differentiation of Isl1+ cardiovascular progenitors are controlled by a Wnt/beta-catenin pathway Cell Stem Cell  2007 1:165-179  DOI:10.1016/j.stem.2007.05.018  PMID:18371348
    • degree-related publication Chen, S., Takanashi, S. C., Zhang, Q. S., Xiong, W., Zhu, S. T., Peters, E. C., Ding, S., Schultz, P. G. Reversine increases the plasticity of lineage-committed mammalian cells Proceedings of the National Academy of Sciences of the United States of America  2007 104:10482-10487  DOI:10.1073/pnas.0704360104  PMID:17566101  PMCID:PMC1965539
    • degree-related publication Liu, W. S., Brock, A., Chen, S., Chen, S., Schultz, P. G. Genetic incorporation of unnatural amino acids into proteins in mammalian cells Nature Methods  2007 4:239-244  DOI:10.1038/nmeth1016  PMID:17322890
    • degree-related publication Chen, S., Do, J. T., Zhang, Q. S., Yao, S. Y., Yan, F., Peters, E. C., Scholer, H. R., Schultz, P. G., Ding, S. Self-renewal of embryonic stem cells by a small molecule Proceedings of the National Academy of Sciences of the United States of America  2006 103:17266-17271  DOI:10.1073/pnas.0608156103  PMID:17088537  PMCID:PMC1859921
    • degree-related publication Yao, S., Chen, S., Clark, J., Hao, E., Beattie, G. M., Hayek, A., Ding, S. Long-term self-renewal and directed differentiation of human embryonic stem cells in chemically defined conditions Proceedings of the National Academy of Sciences of the United States of America  2006 103:6907-6912  DOI:10.1073/pnas.0602280103  PMID:16632596  PMCID:PMC1458992
    • degree-related publication Chen, S., Hilcove, S., Ding, S. Exploring stem cell biology with small molecules Molecular Biosystems  2006 2:18-24  DOI:10.1039/b512000b  PMID:16880919
    • degree-related publication Chen, S., Zhang, Q. S., Wu, X., Schultz, P. G., Ding, S. Dedifferentiation of lineage-committed cells by a small molecule Journal of the American Chemical Society  2004 126:410-411  DOI:10.1021/ja037390k  PMID:14719906
    • Chen, Z., Tong, Y., Chen, S., Li, Y. M., Chen, Y., Zhao, Y. F., Wang, J. Orientation of the peptide formation of N-phosphoryl amino acids in solution Chinese Science Bulletin  2002 47:1866-1870  DOI:10.1360/02tb9408
    • Chen, Z., Chen, S., Chen, Y., Li, Y. M., Chen, J., Zhao, Y. F. Negative-ion electrospray ionization tandem mass spectrometry of N-phosphoryl amino acids and dipeptides Rapid Communications in Mass Spectrometry  2002 16:790-796  DOI:10.1002/rcm.631  PMID:11921264
    • Chen, S., Li, Y. M., Luo, S. Z., Zhao, G., Tan, B., Zhao, Y. F. The study of phosphoramidite as O-phosphitylation agent and its reactivity Phosphorus Sulfur and Silicon and the Related Elements  2000 164:277-291  DOI:10.1080/10426500008045253
  • chapter

    • degree-related publication Chen, S., Ding, S. GSK-3 and stem cells Glycogen Synthase Kinase 3 (GSK-3) and Its Inhibitors: Drug Discovery and Development. 155-172. 2006
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Background

education and training

  • Ph.D. in Chemistry, Scripps Research 2002 - 2006
  • M.S. in Chemistry, Tsinghua University 1999 - 2002
  • B.S. in Chemistry, Tsinghua University 1996 - 1999

advisee of

  • graduate advising relationship

    • Schultz, Peter, Ph.D.  candidacy, 2003 - 2006
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Contact

full name

  • Shuibing Chen

geographic location

  • Scripps California 

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