Chappie, Joshua S

Graduate Student

Positions

2013 - Faculty Member and Nancy and Peter Meinig Family Investigator in the Life Sciences, Cornell University
2009 - 2013 IRTA Postdoctoral Fellow, National Institutes of Health

Websites

Doctoral Dissertation

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academic article
- Murphy, S. G., Alvarez, L., Adams, M. C., Liu, S., Chappie, J. S., Cava, F., Dorr, T. Endopeptidase regulation as a novel function of the Zur-dependent zinc starvation response MBio 2019 10:e02620-18 DOI:10.1128/mBio.02620-18 PMID:30782657 PMCID:PMC6381278
- Varlakhanova, N. V., Alvarez, F. J. D., Brady, T. M., Tornabene, B. A., Hosford, C. J., Chappie, J. S., Zhang, P., Ford, M. G. J. Structures of the fungal dynamin-related protein Vps1 reveal a unique, open helical architecture Journal of Cell Biology 2018 217:3608-3624 DOI:10.1083/jcb.201712021 PMID:30087125 PMCID:PMC6168280
- Hosford, C. J., Chappie, J. S. The crystal structure of the Helicobacter pylori LlaJI.R1 N-terminal domain provides a model for site-specific DNA binding Journal of Biological Chemistry 2018 293:11758-11771 DOI:10.1074/jbc.RA118.001888 PMID:29895618 PMCID:PMC6066307
- Sundborger, A. C., Fang, S., Heymann, J. A., Ray, P., Chappie, J. S., Hinshaw, J. E. A dynamin mutant defines a superconstricted prefission state Cell Reports 2014 8:734-742 DOI:10.1016/j.celrep.2014.06.054 PMID:25088425 PMCID:PMC4142656
- Chappie, J. S., Dyda, F. Building a fission machine - structural insights into dynamin assembly and activation Journal of Cell Science 2013 126:2773-2784 DOI:10.1242/jcs.108845 PMID:23781021 PMCID:PMC4067269
- Maggin, J. E., James, J. A., Chappie, J. S., Dyda, F., Hickman, A. B. The amino acid linker between the endonuclease and helicase domains of adeno-associated virus type 5 Rep plays a critical role in DNA-dependent oligomerization Journal of Virology 2012 86:3337-3346 DOI:10.1128/jvi.06775-11 PMID:22205752 PMCID:PMC3302307
- Chappie, J. S., Mears, J. A., Fang, S. M., Leonard, M., Schmid, S. L., Milligan, R. A., Hinshaw, J. E., Dyda, F. A pseudoatomic model of the dynamin polymer identifies a hydrolysis-dependent powerstroke Cell 2011 147:209-222 DOI:10.1016/j.cell.2011.09.003 PMID:21962517 PMCID:PMC3185303
- Wilson-Kubalek, E. M., Chappie, J. S., Arthur, C. P. Helical crystallization of soluble and membrane binding proteins Methods in Enzymology 2010 481:45-62 DOI:10.1016/s0076-6879(10)81002-x PMID:20887852
- Chappie, J. S., Acharya, S., Leonard, M., Schmid, S. L., Dyda, F. G domain dimerization controls dynamin's assembly-stimulated gtpase activity Nature 2010 465:435-440 DOI:10.1038/nature09032 PMID:20428113 PMCID:PMC2879890
- Chappie, J. S., Acharya, S., Liu, Y. W., Leonard, M., Pucadyil, T. J., Schmid, S. L. An intramolecular signaling element that modulates dynamin function in vitro and in vivo Molecular Biology of the Cell 2009 20:3561-3571 DOI:10.1091/mbc.E09-04-0318 PMID:19515832 PMCID:PMC2719574
- Littlefield, K. P., Ward, A. B., Chappie, J. S., Reedy, M. K., Bernstein, S. I., Milligan, R. A., Reedy, M. C. Similarities and differences between frozen-hydrated, rigor acto-S1 complexes of insect flight and chicken skeletal muscles Journal of Molecular Biology 2008 381:519-528 DOI:10.1016/j.jmb.2008.06.029 PMID:18588896 PMCID:PMC2567842
- Ramachandran, R., Surka, M., Chappie, J. S., Fowler, D. M., Foss, T. R., Song, B. D., Schmid, S. L. The dynamin middle domain is critical for tetramerization and higher-order self-assembly EMBO Journal 2007 26:559-566 DOI:10.1038/sj.emboj.7601491 PMID:17170701 PMCID:PMC1783472
- Cheeseman, I. M., Chappie, J. S., Wilson-Kubalek, E. M., Desai, A. The conserved KMN network constitutes the core microtubule-binding site of the kinetochore Cell 2006 127:983-997 DOI:10.1016/j.cell.2006.09.039 PMID:17129783
- Chappie, J. S., Canaves, J. M., Han, G. W., Rife, C. L., Xu, C. P., Stevens, R. C. The structure of a eukaryotic nicotinic acid phosphoribosyltransferase reveals structural heterogeneity among type iiptrases Structure 2005 13:1385-1396 DOI:10.1016/j.str.2005.05.016 PMID:16154095
- Nimigean, C. M., Chappie, J. S., Miller, C. Electrostatic tuning of ion conductance in potassium channels Biochemistry 2003 42:9263-9268 DOI:10.1021/bi0348720