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Chapados, Brian R
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Chapados, Brian R

Graduate Student
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Positions

  • 2013 - Software Engineer, Anki
  • 2012 - Senior Software Engineer, Hang, Inc.
  • 2010 - 2012 Software Engineer, Booyah, Inc.
  • 2005 - 2010 Postdoctoral Research Fellow, Scripps Research

Websites

  • Doctoral Dissertation
  • Publications
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Publications

recent publications
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  • academic article

    • Tsutakawa, S. E., Classen, S., Chapados, B. R., Arvai, A. S., Finger, L. D., Guenther, G., Tomlinson, C. G., Thompson, P., Sarker, A. H., Shen, B. H., Cooper, P. K., Grasby, J. A., et al. Human flap endonuclease structures, DNA double-base flipping, and a unified understanding of the fen1 superfamily Cell  2011 145:198-211  DOI:10.1016/j.cell.2011.03.004  PMID:21496641  PMCID:PMC3086263
    • Zeitlin, S. G., Chapados, B. R., Baker, N. M., Tai, C., Slupphaug, G., Wang, J. Y. J. Uracil DNA N-glycosylase promotes assembly of human centromere protein A PLoS One  2011 6  DOI:10.1371/journal.pone.0017151  PMID:21399697  PMCID:PMC3047565
    • Tomlinson, C. G., Atack, J. M., Chapados, B., Tainer, J. A., Grasby, J. A. Substrate recognition and catalysis by flap endonucleases and related enzymes Biochemical Society Transactions  2010 38:433-437  DOI:10.1042/BST0380433  PMID:20298197
    • Zeitlin, S. G., Baker, N. M., Chapados, B. R., Soutoglou, E., Wang, J. Y. J., Berns, M. W., Cleveland, D. W. Double-strand DNA breaks recruit the centromeric histone CENP-A Proceedings of the National Academy of Sciences of the United States of America  2009 106:15762-15767  DOI:10.1073/pnas.0908233106  PMID:19717431  PMCID:PMC2747192
    • Syson, K., Tomlinson, C., Chapados, B. R., Sayers, J. R., Tainer, J. A., Williams, N. H., Grasby, J. A. Three metal ions participate in the reaction catalyzed by t5 flap endonuclease Journal of Biological Chemistry  2008 283:28741-28746  DOI:10.1074/jbc.M801264200  PMID:18697748  PMCID:PMC2568906
    • Williams, R., Sengerowa, B., Osborne, S., Syson, K., Ault, S., Kilgour, A., Chapados, B. R., Tainer, J. A., Sayers, J. R., Grasby, J. A. Comparison of the catalytic parameters and reaction specificities of a phage and an archaeal flap endonuclease Journal of Molecular Biology  2007 371:34-48  DOI:10.1016/j.jmb.2007.04.063  PMID:17559871  PMCID:PMC1993357
    • Vijayakumar, S., Chapados, B. R., Schmidt, K. H., Kolodner, R. D., Tainer, J. A., Tomkinson, A. E. The c-terminal domain of yeast pcna is required for physical and functional interactions with cdc9 DNA ligase Nucleic Acids Research  2007 35:1624-1637  DOI:10.1093/nar/gkm006  PMID:17308348  PMCID:PMC1865074
    • Ivanov, I., Chapados, B. R., McCammon, J. A., Tainer, J. A. Proliferating cell nuclear antigen loaded onto double-stranded DNA: Dynamics, minor groove interactions and functional implications Nucleic Acids Research  2006 34:6023-6033  DOI:10.1093/nar/gkl744  PMID:17071716  PMCID:PMC1635319
    • degree-related publication Chao, J. A., Lee, J. H., Chapados, B. R., Debler, E. W., Schneemann, A., Williamson, J. R. Dual modes of RNA-silencing suppression by Flock House virus protein B2 Nature Structural & Molecular Biology  2005 12:952-957  DOI:10.1038/nsmb1005  PMID:16228003
    • degree-related publication Qiu, J. Z., Liu, R., Chapados, B. R., Sherman, M., Tainer, J. A., Shen, B. H. Interaction interface of human flap endonuclease-1 with its DNA substrates Journal of Biological Chemistry  2004 279:24394-24402  DOI:10.1074/jbc.M401464200  PMID:15037610
    • degree-related publication Chapados, B. R., Hosfield, D. J., Han, S., Qiu, J. Z., Yelent, B., Shen, B. H., Tainer, J. A. Structural basis for FEN-1 substrate specificity and PCNA-mediated activation in DNA replication and repair Cell  2004 116:39-50  DOI:10.1016/s0092-8674(03)01036-5  PMID:14718165
    • degree-related publication Chai, Q., Qiu, J., Chapados, B. R., Shen, B. Archaeoglobus fulgidus RNase HII in DNA replication: enzymological functions and activity regulation via metal cofactors Biochemical and Biophysical Research Communications  2001 286:1073-1081  DOI:10.1006/bbrc.2001.5523  PMID:11527410
    • degree-related publication Chapados, B. R., Chai, Q., Hosfield, D. J., Qiu, J. Z., Shen, B. H., Tainer, J. A. Structural biochemistry of a type 2 rnase h: Rna primer recognition and removal during DNA replication Journal of Molecular Biology  2001 307:541-556  DOI:10.1006/jmbi.2001.4494  PMID:11254381
    • Kabza, K. G., Chapados, B. R., Gestwicki, J. E., McGrath, J. L. Microwave-induced esterification using heterogeneous acid catalyst in a low dielectric constant medium Journal of Organic Chemistry  2000 65:1210-1214  DOI:10.1021/jo990515c  PMID:10814074
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Background

education and training

  • Ph.D. in Macromolecular and Cellular Structure and Chemistry, Scripps Research 1999 - 2005

advisee of

  • graduate advising relationship

    • Tainer, John, Ph.D.  candidacy, 2000 - 2005
  • postdoc or fellow advising relationship

    • Tainer, John, Ph.D.  candidacy, 2005 - 2010
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Contact

full name

  • Brian R Chapados

geographic location

  • Scripps California 

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