Catz, Sergio

Faculty Member

Positions

Professor, Molecular Medicine , The Scripps Research Institute 2017 -
Associate Professor, Molecular Medicine , The Scripps Research Institute 2017
Associate Professor, Molecular and Experimental Medicine (MEM) , The Scripps Research Institute 1998 - 2017

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scatz@scripps.edu

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- Zhang, J., Johnson, J. L., He, J., Napolitano, G., Ramadass, M., Rocca, C., Kiosses, W. B., Bucci, C., Xin, Q., Gavathiotis, E., Cuervo, A. M., Cherqui, S., et al. Cystinosin, the small GTPase Rab11, and the Rab7 effector RILP regulate intracellular trafficking of the chaperone-mediated autophagy receptor LAMP2A Journal of Biological Chemistry 2017 292:10328-10346 DOI:10.1074/jbc.M116.764076 PMID:28465352 PMCID:PMC5481548
- Catz, S. D. Editorial: The secrets of secretion Journal of Leukocyte Biology 2017 102:4-6 DOI:10.1189/jlb.3CE0217-046R PMID:28667084
- Johnson, J. L., Ramadass, M., Haimovich, A., McGeough, M. D., Zhang, J., Hoffman, H. M., Catz, S. D. Increased neutrophil secretion induced by NLRP3 mutation links the inflammasome to azurophilic granule exocytosis Frontiers in Cellular and Infection Microbiology 2017 7 DOI:10.3389/fcimb.2017.00507
- Ramadass, M., Johnson, J. L., Catz, S. D. Rab27a regulates GM-CSF-dependent priming of neutrophil exocytosis Journal of Leukocyte Biology 2017 101:693-702 DOI:10.1189/jlb.3AB0416-189RR PMID:27733578
- Rega, L. R., Polishchuk, E., Montefusco, S., Napolitano, G., Tozzi, G., Zhang, J., Bellomo, F., Taranta, A., Pastore, A., Polishchuk, R., Piemonte, F., Medina, D. L., et al. Activation of the transcription factor EB rescues lysosomal abnormalities in cystinotic kidney cells Kidney International 2016 89:862-873 DOI:10.1016/j.kint.2015.12.045 PMID:26994576
- Johnson, J. L., Ramadass, M., He, J., Brown, S. J., Zhang, J., Abgaryan, L., Biris, N., Gavathiotis, E., Rosen, H., Catz, S. D. Identification of neutrophil exocytosis inhibitors (Nexinhibs), small molecule inhibitors of neutrophil exocytosis and inflammation: druggability of the small GTPase Rab27a Journal of Biological Chemistry 2016 291:25965-25982 DOI:10.1074/jbc.M116.741884 PMID:27702998 PMCID:PMC5207069
- Kurz, A. R. M., Pruenster, M., Rohwedder, I., Ramadass, M., Schafer, K., Harrison, U., Gouveia, G., Nussbaum, C., Immler, R., Wiessner, J. R., Margraf, A., Lim, D. S., et al. MST1-dependent vesicle trafficking regulates neutrophil transmigration through the vascular basement membrane Journal of Clinical Investigation 2016 126:4125-4139 DOI:10.1172/jci87043 PMID:27701149 PMCID:PMC5096904
- Ramadass, M., Catz, S. D. Molecular mechanisms regulating secretory organelles and endosomes in neutrophils and their implications for inflammation Immunological Reviews 2016 273:249-265 DOI:10.1111/imr.12452 PMID:27558339
- Johnson, J. L., He, J., Ramadass, M., Pestonjamasp, K., Kiosses, W. B., Zhang, J. Z., Catz, S. D. Munc13-4 Is a Rab11-binding protein that regulates Rab11-positive vesicle trafficking and docking at the plasma membrane Journal of Biological Chemistry 2016 291:3423-3438 DOI:10.1074/jbc.M115.705871 PMID:26637356 PMCID:PMC4751385
- He, J., Johnson, J. L., Monfregola, J., Ramadass, M., Pestonjamasp, K., Napolitano, G., Zhang, J., Catz, S. D. Munc13-4 interacts with syntaxin 7 and regulates late endosomal maturation, endosomal signaling, and TLR9-initiated cellular responses Molecular Biology of the Cell 2016 27:572-587 DOI:10.1091/mbc.E15-05-0283 PMID:26680738 PMCID:PMC4751605
- Napolitano, G., Johnson, J. L., He, J., Rocca, C. J., Monfregola, J., Pestonjamasp, K., Cherqui, S., Catz, S. D. Impairment of chaperone-mediated autophagy leads to selective lysosomal degradation defects in the lysosomal storage disease cystinosis EMBO Molecular Medicine 2015 7:158-174 DOI:10.15252/emmm.201404223 PMID:25586965 PMCID:PMC4328646
- Sasaki, T., Lian, S., Qi, J., Bayliss, P. E., Carr, C. E., Johnson, J. L., Guha, S., Kobler, P., Catz, S. D., Gill, M., Jia, K., Klionsky, D. J., et al. Aberrant autolysosomal regulation is linked to the induction of embryonic senescence: differential roles of Beclin 1 and p53 in vertebrate Spns1 deficiency PLoS Genetics 2014 10:e1004409 DOI:10.1371/journal.pgen.1004409 PMID:24967584 PMCID:PMC4072523
- Singh, R. K., Mizuno, K., Wasmeier, C., Wavre-Shapton, S. T., Recchi, C., Catz, S. D., Futter, C., Tolmachova, T., Hume, A. N., Seabra, M. C. Distinct and opposing roles for Rab27a/MIph/MyoVa and Rab27b/Munc13-4 in mast cell secretion FEBS Journal 2013 280:892-903 DOI:10.1111/febs.12081 PMID:23281710
- Catz, S. D. Regulation of vesicular trafficking and leukocyte function by Rab27 GTPases and their effectors Journal of Leukocyte Biology 2013 94:613-622 DOI:10.1189/jlb.1112600 PMID:23378593 PMCID:PMC3774847
- Johnson, J. L., Napolitano, G., Monfregola, J., Rocca, C. J., Cherqui, S., Catz, S. D. Upregulation of the Rab27a-dependent trafficking and secretory mechanisms improves lysosomal transport, alleviates endoplasmic reticulum stress, and reduces lysosome overload in cystinosis Molecular and Cellular Biology 2013 33:2950-2962 DOI:10.1128/mcb.00417-13 PMID:23716592 PMCID:PMC3719680
- Johnson, J. L., Monfregola, J., Napolitano, G., Kiosses, W. B., Catz, S. D. Vesicular trafficking through cortical actin during exocytosis is regulated by the Rab27a effector JFC1/Slp1 and the RhoA-GTPase-activating protein Gem-interacting protein Molecular Biology of the Cell 2012 23:1902-1916 DOI:10.1091/mbc.E11-12-1001 PMID:22438581 PMCID:PMC3350554
- Johnson, J. L., Hong, H., Monfregola, J., Catz, S. D. Increased survival and reduced neutrophil infiltration of the liver in Rab27a-but not Munc13-4-deficient mice in lipopolysaccharide-induced systemic inflammation Infection and Immunity 2011 79:3607-3618 DOI:10.1128/iai.05043-11 PMID:21746860 PMCID:PMC3165471
- Johnson, J. L., Hong, H., Monfregola, J., Kiosses, W. B., Catz, S. D. Munc13-4 restricts motility of rab27a-expressing vesicles to facilitate lipopolysaccharide-induced priming of exocytosis in neutrophils Journal of Biological Chemistry 2011 286:5647-5656 DOI:10.1074/jbc.M110.184762 PMID:21148308 PMCID:PMC3037678
- Johnson, J. L., Brzezinska, A. A., Tolmachova, T., Munafo, D. B., Ellis, B. A., Seabra, M. C., Hong, H., Catz, S. D. Rab27a and Rab27b regulate neutrophil azurophilic granule exocytosis and NADPH oxidase activity by independent mechanisms Traffic 2010 11:533-547 DOI:10.1111/j.1600-0854.2009.01029.x PMID:20028487 PMCID:PMC2937183
- Munafo, D. B., Johnson, J. L., Brzezinska, A. A., Ellis, B. A., Wood, M. R., Catz, S. D. DNase I inhibits a late phase of reactive oxygen species production in neutrophils Journal of Innate Immunity 2009 1:527-542 DOI:10.1159/000235860 PMID:20375609 PMCID:PMC2919508
- Brzezinska, A. A., Johnson, J. L., Munafo, D. B., Ellis, B. A., Catz, S. D. Signalling mechanisms for toll-like receptor-activated neutrophil exocytosis: Key roles for interleukin-1-receptor-associated kinase-4 and phosphatidylinositol 3-kinase but not toll/il-1 receptor (tir) domain-containing adaptor inducing ifn-beta (trif) Immunology 2009 127:386-397 DOI:10.1111/j.1365-2567.2008.02980.x PMID:19019092 PMCID:PMC2712107
- Brzezinska, A. A., Johnson, J. L., Munafo, D. B., Crozat, K., Beutler, B., Kiosses, W. B., Ellis, B. A., Catz, S. D. The Rab27a effectors JFC1/Slp1 and Munc13-4 regulate exocytosis of neutrophil granules Traffic 2008 9:2151-2164 DOI:10.1111/j.1600-0854.2008.00838.x PMID:18939952
- Pacquelet, S., Johnson, J. L., Ellis, B. A., Brzezinska, A. A., Lane, W. S., Munafo, D. B., Catz, S. D. Cross-talk between IRAK-4 and the NADPH oxidase Biochemical Journal 2007 403:451-461 DOI:10.1042/bj20061184 PMID:17217339
- Munafo, D. B., Johnson, J. L., Ellis, B. A., Rutschmann, S., Beutler, B., Catz, S. D. Rab27a is a key component of the secretory machinery of azurophilic granules in granulocytes Biochemical Journal 2007 402:229-239 DOI:10.1042/bj20060950 PMID:17090228
- Johnson, J. L., Ellis, B. A., Munafo, D. B., Brzezinska, A. A., Catz, S. D. Gene transfer and expression in human neutrophils. The phox homology domain of p47(phox) translocates to the plasma membrane but not to the membrane of mature phagosomes BMC Immunology 2006 7:28 DOI:10.1186/1471-2172-7-28 PMID:17150107 PMCID:PMC1712351
- Johnson, J. L., Pacquelet, S., Lane, W. S., Eam, B., Catz, S. D. Akt regulates the subcellular localization of the Rab27a-binding protein JFC1 by phosphorylation Traffic 2005 6:667-681 DOI:10.1111/j.1600-0854.2005.00308.x PMID:15998322
- Johnson, J. L., Ellis, B. A., Noack, D., Seabra, M. C., Catz, S. D. The Rab27a-binding protein, JFC1, regulates androgen-dependent secretion of prostate-specific antigen and prostatic-specific acid phosphatase Biochemical Journal 2005 391:699-710 DOI:10.1042/bj20050380 PMID:16004602
- Catz, S. D., Johnson, J. L. BCL-2 in prostate cancer: A minireview Apoptosis 2003 8:29-37 DOI:10.1023/a:1021692801278 PMID:12510149
- Hoyal, C. R., Gutierrez, A., Young, B. M., Catz, S. D., Lin, J. H., Tsichlis, P. N., Babior, B. M. Modulation of p47(PHOX) activity by site-specific phosphorylation: Akt-dependent activation of the NADPH oxidase Proceedings of the National Academy of Sciences of the United States of America 2003 100:5130-5135 DOI:10.1073/pnas.1031526100 PMID:12704229 PMCID:PMC154310
- Catz, S. D., Babior, B. M., Johnson, J. L. JFC1 is transcriptionally activated by nuclear factor-kappa B and up-regulated by tumour necrosis factor alpha in prostate carcinoma cells Biochemical Journal 2002 367:791-799 DOI:10.1042/bj20020345 PMID:12137562
- Catz, S. D., Johnson, J. L., Babior, B. M. The C2A domain of JFC1 binds to 3 '-phosphorylated phosphoinositides and directs plasma membrane association in living cells Proceedings of the National Academy of Sciences of the United States of America 2002 99:11652-11657 DOI:10.1073/pnas.172382799 PMID:12189202 PMCID:PMC129324
- Catz, S. D., Johnson, J. L., Babior, B. M. Characterization of the nucleotide-binding capacity and the ATPase activity of the PIP3-binding protein JFC1 Proceedings of the National Academy of Sciences of the United States of America 2001 98:11230-11235 DOI:10.1073/pnas.191369598 PMID:11553774 PMCID:PMC58712
- Berkowitz, J. K. M., Catz, S. D., Johnson, J. L., Ruedi, J. M., Thon, V., Babior, B. M. JFC1, a novel tandem C2 domain-containing protein associated with the leukocyte NADPH oxidase Journal of Biological Chemistry 2001 276:18855-18862 DOI:10.1074/jbc.M011167200 PMID:11278853
- Catz, S. D., Johnson, J. L. Transcriptional regulation of BCL-2 by nuclear factor kappa B and its significance in prostate cancer Oncogene 2001 20:7342-7351 DOI:10.1038/sj.onc.1204926 PMID:11704864
- Catz, S. D., Speziale, E. H., Sterin-Speziale, N. B. Polyphosphoinositide synthesis in human neutrophils - effects of a low metabolic energy state Prostaglandins & Other Lipid Mediators 1998 55:245-264 DOI:10.1016/s0090-6980(98)00021-5 PMID:9644115
- Catz, S. D., SterinSpeziale, N. B. Bradykinin stimulates phosphoinositide turnover and phospholipase C but not phospholipase D and NADPH oxidase in human neutrophils Journal of Leukocyte Biology 1996 59:591-597 PMID:8613709
- Peralta, J., Reides, C., Garcia, S., Llesuy, S., Pargament, G., Carreras, M. C., Catz, S., Poderoso, J. J. Oxidative stress in rodent closed duodenal loop pancreatitis International Journal of Pancreatology 1996 19:61-69 PMID:8656029
- Kahane, V. L., Cutrin, J. C., Setton, C. P., Fernandez, M. D., Catz, S. D., Sterinspeziale, N. B. Biochemical and morphological-changes in the developing kidney Biology of the Neonate 1995 68:141-152 PMID:8534774
- Catz, S. D., Carreras, M. C., Poderoso, J. J. Nitric oxide synthase inhibitors decrease human polymorphonuclear leukocyte luminol-dependent chemiluminescence Free Radical Biology and Medicine 1995 19:741-748 DOI:10.1016/0891-5849(95)00065-6 PMID:8582646
- Carreras, M. C., Catz, S. D., Pargament, G. A., Delbosco, C. G., Poderoso, J. J. Decreased production of nitric oxide by human neutrophils during septic multiple organ dysfunction syndrome. Comparison with endotoxin and cytokine effects on normal cells Inflammation 1994 18:151-161 DOI:10.1007/bf01534556 PMID:8070900
- Carreras, M. C., Pargament, G. A., Catz, S. D., Poderoso, J. J., Boveris, A. Kinetics of nitric oxide and hydrogen peroxide production and formation of peroxynitrite during the respiratory burst of human neutrophils FEBS Letters 1994 341:65-68 DOI:10.1016/0014-5793(94)80241-6 PMID:8137924
- Hoschoian, J. C., Catz, S. D., Borruel, M. A., Wikinski, R. L., Rodriguez, M. P. Evaluation of the blood components considered as risk predictors in coronary heart-disease Medicina-Buenos Aires 1993 53:13-20 PMID:8246725