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Burton, Dennis
Faculty Member
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Positions
- 2017 - Co-Chair, Immunology and Microbiology , Scripps Research
- 2017 - Professor, Immunology and Microbiology , Scripps Research
- 2015 - James and Jessie Minor Chair in Immunology, Scripps Research
- 2012 - Director, Center for HIV/AIDS Vaccine Immunology and Immunogen Discovery (CHAVI-ID)
- 2012 - Immunologist,, Massachusetts General Hospital
- 2008 - Visiting Professor, Oxford Centre in Virology, University of Oxford
- 2002 - Director, IAVI Neutralizing Antibody Center
- 1991 - Faculty Member, Skaggs Graduate School of Chemical and Biological Sciences , Scripps Research
- Faculty Member and Program Leader, Ragon Institute of MGH, MIT and Harvard
- 2015 - 2017 Chairman, Immunology and Microbial Science (IMS) , Scripps Research
- 1991 - 2017 Professor, Immunology and Microbial Science (IMS) , Scripps Research
- 2015 Distinguished Lecturer, The American Association of Immunologists
- - 2012 Professor (Joint Appointment), Molecular Biology , Scripps Research
- 1990 - 1991 Personal Chair, The University of Sheffield
- 1989 - 1991 Visiting Member, Research Institute of Scripps Clinic
- 1985 - 1991 Jenner Fellow, Lister Institute of Preventive Medicine
- 1987 - 1990 Senior Lecturer in Biochemistry, The University of Sheffield
- 1981 - 1987 Lecturer in Biochemistry, The University of Sheffield
- 1980 - 1981 Junior Research Fellow, Wolfson College, University of Oxford
- 1979 - 1981 Medical Research Council Training Fellowship, University of Oxford
Dr. Dennis Burton focuses his research primarily on human antibody responses to HIV and the design of an HIV vaccine. He has also worked on the interaction of antibodies and other pathogens, including respiratory syncytial virus, Ebola virus and prion proteins.
Research Areas
- Hepatitis C (UMLS)
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Publications
recent publications
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academic article
- Burton, D. R. Advancing an HIV vaccine; advancing vaccinology Nature Reviews Immunology 2019 19:77-78 DOI:10.1038/s41577-018-0103-6 PMID:30560910
- Briney, B., Inderbitzin, A., Joyce, C., Burton, D. R. Commonality despite exceptional diversity in the baseline human antibody repertoire Nature 2019 566:393-397 DOI:10.1038/s41586-019-0879-y PMID:30664748
- Voss, J. E., Gonzalez-Martin, A., Andrabi, R., Fuller, R. P., Murrell, B., McCoy, L. E., Porter, K., Huang, D., Li, W., Sok, D., Le, K., Briney, B., et al. Reprogramming the antigen specificity of B cells using genome-editing technologies ELife 2019 8 DOI:10.7554/eLife.42995 PMID:30648968 PMCID:PMC6355199
- Cirelli, K. M., Carnathan, D. G., Nogal, B., Martin, J. T., Rodriguez, O. L., Upadhyay, A. A., Enemuo, C. A., Gebru, E. H., Choe, Y., Viviano, F., Nakao, C., Pauthner, M. G., et al. Slow delivery immunization enhances HIV neutralizing antibody and germinal center responses via modulation of immunodominance Cell 2019 177:1153-1171 DOI:10.1016/j.cell.2019.04.012 PMID:31080066
- Andrabi, R., Pallesen, J., Allen, J. D., Song, G., Zhang, J., de Val, N., Gegg, G., Porter, K., Su, C., Pauthner, M., Newman, A., Bouton-Verville, H., et al. The chimpanzee SIV envelope trimer: structure and deployment as an HIV vaccine template Cell Reports 2019 27:2426-2441 DOI:10.1016/j.celrep.2019.04.082 PMID:31116986 PMCID:PMC6533203
- Pauthner, M. G., Nkolola, J. P., Havenar-Daughton, C., Murrell, B., Reiss, S. M., Bastidas, R., Prevost, J., Nedellec, R., von Bredow, B., Abbink, P., Cottrell, C. A., Kulp, D. W., et al. Vaccine-induced protection from homologous tier 2 SHIV challenge in nonhuman primates depends on serum-neutralizing antibody titers Immunity 2019 50:241-252 DOI:10.1016/j.immuni.2018.11.011 PMID:30552025 PMCID:PMC6335502
- Zhou, T., Zheng, A., Baxa, U., Chuang, G. Y., Georgiev, I. S., Kong, R., O'Dell, S., Shahzad-Ul-Hussan, S., Shen, C. H., Tsybovsky, Y., Bailer, R. T., Gift, S. K., et al. A neutralizing antibody recognizing primarily N-linked glycan targets the silent face of the HIV envelope Immunity 2018 48:500-513 DOI:10.1016/j.immuni.2018.02.013 PMID:29548671
- Allen, E. R., Krumm, S. A., Raghwani, J., Halldorsson, S., Elliott, A., Graham, V. A., Koudriakova, E., Harlos, K., Wright, D., Warimwe, G. M., Brennan, B., Huiskonen, J. T., et al. A protective monoclonal antibody targets a site of vulnerability on the surface of Rift Valley fever virus Cell Reports 2018 25:3750-3758 DOI:10.1016/j.celrep.2018.12.001 PMID:30590046 PMCID:PMC6315105
- Cao, L. W., Pauthner, M., Andrabi, R., Rantalainen, K., Berndsen, Z., Diedrich, J. K., Menis, S., Sok, D., Bastidas, R., Park, S. K. R., Delahunty, C. M., He, L., et al. Differential processing of HIV envelope glycans on the virus and soluble recombinant trimer Nature Communications 2018 9 DOI:10.1038/s41467-018-06121-4 PMID:30209313 PMCID:PMC6135743
- Bianchi, M., Turner, H. L., Nogal, B., Cottrell, C. A., Oyen, D., Pauthner, M., Bastidas, R., Nedellec, R., McCoy, L. E., Wilson, I. A., Burton, D. R., Ward, A. B., et al. Electron-microscopy-based epitope mapping defines specificities of polyclonal antibodies elicited during HIV-1 BG505 envelope trimer immunization Immunity 2018 49:288-300 DOI:10.1016/j.immuni.2018.07.009 PMID:30097292 PMCID:PMC6104742
- Magnani, D. M., Rogers, T. F., Maness, N. J., Grubaugh, N. D., Beutler, N., Bailey, V. K., Gonzalez-Nieto, L., Gutman, M. J., Pedreno-Lopez, N., Kwal, J. M., Ricciardi, M. J., Myers, T. A., et al. Fetal demise and failed antibody therapy during Zika virus infection of pregnant macaques Nature Communications 2018 9 DOI:10.1038/s41467-018-04056-4 PMID:29691387 PMCID:PMC5915455
- Cao, L., Diedrich, J. K., Ma, Y., Wang, N., Pauthner, M., Park, S. K. R., Delahunty, C. M., McLellan, J. S., Burton, D. R., Yates III, J. R., Paulson, J. C. Global site-specific analysis of glycoprotein N-glycan processing Nature Protocols 2018 13:1196-1212 DOI:10.1038/nprot.2018.024 PMID:29725121 PMCID:PMC5941933
- He, L., Kumar, S., Allen, J. D., Huang, D. L., Lin, X., Mann, C. J., Saye-Francisco, K. L., Copps, J., Sarkar, A., Blizard, G. S., Ozorowski, G., Sok, D., et al. HIV-1 vaccine design through minimizing envelope metastability Science Advances 2018 4 DOI:10.1126/sciadv.aau6769 PMID:30474059 PMCID:PMC6248932
- Martins, M. A., Tully, D. C., Pedreno-Lopez, N., von Bredow, B., Pauthner, M. G., Shin, Y. C., Yuan, M. L., Lima, N. S., Bean, D. J., Gonzalez-Nieto, L., Domingues, A., Gutman, M. J., et al. Mamu-B*17(+) rhesus macaques vaccinated with env, vif, and nef manifest early control of SIVmac239 replication Journal of Virology 2018 92:e00690-18 DOI:10.1128/jvi.00690-18 PMID:29875239 PMCID:PMC6069176
- Walker, L. M., Burton, D. R. Passive immunotherapy of viral infections: 'super-antibodies' enter the fray Nature Reviews Immunology 2018 18:297-308 DOI:10.1038/nri.2017.148 PMID:29379211 PMCID:PMC5918154
- Wagh, K., Seaman, M. S., Zingg, M., Fitzsimons, T., Barouch, D. H., Burton, D. R., Connore, M., Ho, D. D., Mascola, J. R., Nussenzweig, M. C., Ravetch, J., Gautam, R., et al. Potential of conventional & bispecific broadly neutralizing antibodies for prevention of HIV-1 subtype A, C & D infections PLoS Pathogens 2018 14 DOI:10.1371/journal.ppat.1006860 PMID:29505593 PMCID:PMC5854441
- Sok, D., Burton, D. R. Recent progress in broadly neutralizing antibodies to HIV Nature Immunology 2018 19:1179-1188 DOI:10.1038/s41590-018-0235-7 PMID:30333615
- Andrabi, R., Bhiman, J. N., Burton, D. R. Strategies for a multi-stage neutralizing antibody-based HIV vaccine Current Opinion in Immunology 2018 53:143-151 DOI:10.1016/j.coi.2018.04.025 PMID:29775847 PMCID:PMC6141341
- Saphire, E. O., Schendel, S. L., Fusco, M. L., Gangavarapu, K., Gunn, B. M., Wec, A. Z., Halfmann, P. J., Brannan, J. M., Herbert, A. S., Qiu, X. G., Wagh, K., He, S., et al. Systematic analysis of monoclonal antibodies against Ebola virus GP defines features that contribute to protection Cell 2018 174:938-952 DOI:10.1016/j.cell.2018.07.033 PMID:30096313 PMCID:PMC6102396
- Teijaro, J. R., Burton, D. R. Taking down defenses to improve vaccines Science 2018 359:277-278 DOI:10.1126/science.aar5421 PMID:29348225
- Khan, S. N., Sok, D., Tran, K., Movsesyan, A., Dubrovskaya, V., Burton, D. R., Wyatt, R. T. Targeting the HIV-1 spike and coreceptor with bi- and trispecific antibodies for single-component broad inhibition of entry Journal of Virology 2018 92:e00384-18 DOI:10.1128/jvi.00384-18 PMID:29976677
- Shivatare, V. S., Shivatare, S. S., Lee, C. C. D., Liang, C. H., Liao, K. S., Cheng, Y. Y., Saidachary, G., Wu, C. Y., Lin, N. H., Kwong, P. D., Burton, D. R., Wu, C. Y., et al. Unprecedented role of hybrid N-glycans as ligands for HIV-1 broadly neutralizing antibodies Journal of the American Chemical Society 2018 140:5202-5210 DOI:10.1021/jacs.8b00896 PMID:29578688
- Lee, J. H., Andrabi, R., Su, C. Y., Yasmeen, A., Julien, J. P., Kong, L., Wu, N. C., McBride, R., Sok, D., Pauthner, M., Cottrell, C. A., Nieusma, T., et al. A broadly neutralizing antibody targets the dynamic HIV envelope trimer apex via a long, rigidified, and anionic β-hairpin structure Immunity 2017 46:690-702 DOI:10.1016/j.immuni.2017.03.017 PMID:28423342 PMCID:PMC5400778
- Magnani, D. M., Silveira, C. G. T., Rosen, B. C., Ricciardi, M. J., Pedreno-Lopez, N., Gutman, M. J., Bailey, V. K., Maxwell, H. S., Domingues, A., Gonzalez-Nieto, L., Avelino-Silva, V. I., Trindade, M., et al. A human inferred germline antibody binds to an immunodominant epitope and neutralizes Zika virus PLoS Neglected Tropical Diseases 2017 11 DOI:10.1371/journal.pntd.0005655 PMID:28604797 PMCID:PMC5481143
- Julg, B., Tartaglia, L. J., Keele, B. F., Wagh, K., Pegu, A., Sok, D., Abbink, P., Schmidt, S. D., Wang, K., Chen, X., Joyce, M. G., Georgiev, I. S., et al. Broadly neutralizing antibodies targeting the HIV-1 envelope V2 apex confer protection against a clade C SHIV challenge Science Translational Medicine 2017 9 DOI:10.1126/scitranslmed.aal1321 PMID:28878010
- Freund, N. T., Wang, H., Scharf, L., Nogueira, L., Horwitz, J. A., Bar-On, Y., Golijanin, J., Sievers, S. A., Sok, D., Cai, H., Lorenzi, J. C. C., Halper-Stromberg, A., et al. Coexistence of potent HIV-1 broadly neutralizing antibodies and antibody-sensitive viruses in a viremic controller Science Translational Medicine 2017 9 DOI:10.1126/scitranslmed.aal2144 PMID:28100831
- Magnani, D. M., Ricciardi, M. J., Bailey, V. K., Gutman, M. J., Pedreno-Lopez, N., Silveira, C. G. T., Maxwell, H. S., Domingues, A., Gonzalez-Nieto, L., Su, Q., Newman, R. M., Pack, M., et al. Dengue virus evades AAV-mediated neutralizing antibody prophylaxis in Rhesus monkeys Molecular Therapy 2017 25:2323-2331 DOI:10.1016/j.ymthe.2017.06.020 PMID:28750738 PMCID:PMC5628771
- Morris, C. D., Azadnia, P., de Val, N., Vora, N., Honda, A., Giang, E., Saye-Francisco, K., Cheng, Y. S., Lin, X., Mann, C. J., Tang, J., Sok, D., et al. Differential antibody responses to conserved HIV-1 neutralizing epitopes in the context of multivalent scaffolds and native-like gp140 trimers mBio 2017 8:e00036-17 DOI:10.1128/mBio.00036-17 PMID:28246356 PMCID:PMC5347340
- Voss, J. E., Andrabi, R., McCoy, L. E., de Val, N., Fuller, R. P., Messmer, T., Su, C. Y., Sok, D., Khan, S. N., Garces, F., Pritchard, L. K., Wyatt, R. T., et al. Elicitation of neutralizing antibodies targeting the V2 apex of the HIV Envelope trimer in a wild-type animal model Cell Reports 2017 21:222-235 DOI:10.1016/j.celrep.2017.09.024 PMID:28978475 PMCID:PMC5640805
- Pauthner, M., Havenar-Daughton, C., Sok, D., Nkolola, J. P., Bastidas, R., Boopathy, A. V., Carnathan, D. G., Chandrashekar, A., Cirelli, K. M., Cottrell, C. A., Eroshkin, A. M., Guenaga, J., et al. Elicitation of robust tier 2 neutralizing antibody responses in nonhuman primates by HIV envelope trimer immunization using optimized approaches Immunity 2017 46:1073-1088 DOI:10.1016/j.immuni.2017.05.007 PMID:28636956 PMCID:PMC5483234
- Cao, L., Diedrich, J. K., Kulp, D. W., Pauthner, M., He, L., Park, S. K. R., Sok, D., Su, C. Y., Delahunty, C. M., Menis, S., Andrabi, R., Guenaga, J., et al. Global site-specific N-glycosylation analysis of HIV envelope glycoprotein Nature Communications 2017 8 DOI:10.1038/ncomms14954 PMID:28348411
- Andrabi, R., Su, C. Y., Liang, C. H., Shivatare, S. S., Briney, B., Voss, J. E., Nawazi, S. K., Wu, C. Y., Wong, C. H., Burton, D. R. Glycans function as anchors for antibodies and help drive HIV broadly neutralizing antibody development Immunity 2017 47:524-537 DOI:10.1016/j.immuni.2017.08.006 PMID:28916265 PMCID:PMC5613947
- Haynes, B. F., Burton, D. R. HIV Developing an HIV vaccine Science 2017 355:1129-1130 DOI:10.1126/science.aan0662 PMID:28302812
- Landais, E., Murrell, B., Briney, B., Murrell, S., Rantalainen, K., Berndsen, Z. T., Ramos, A., Wickramasinghe, L., Smith, M. L., Eren, K., de Val, N., Wu, M., et al. HIV envelope glycoform heterogeneity and localized diversity govern the initiation and maturation of a V2 apex broadly neutralizing antibody lineage Immunity 2017 47:990-1003 DOI:10.1016/j.immuni.2017.11.002 PMID:29166592 PMCID:PMC5736302
- He, L., Lin, X., de Val, N., Saye-Francisco, K. L., Mann, C. J., Augst, R., Morris, C. D., Azadnia, P., Zhou, B., Sok, D., Ozorowski, G., Ward, A. B., et al. Hidden lineage complexity of glycan-dependent HIV-1 broadly neutralizing antibodies uncovered by digital panning and native-like gp140 trimer Frontiers in Immunology 2017 8 DOI:10.3389/fimmu.2017.01025
- McCoy, L. E., Burton, D. R. Identification and specificity of broadly neutralizing antibodies against HIV Immunological Reviews 2017 275:11-20 DOI:10.1111/imr.12484 PMID:28133814 PMCID:PMC5299474
- Xie, J., Sok, D., Wu, N. C., Zheng, T., Zhang, W., Burton, D. R., Lerner, R. A. Immunochemical engineering of cell surfaces to generate virus resistance Proceedings of the National Academy of Sciences of the United States of America 2017 114:4655-4660 DOI:10.1073/pnas.1702764114 PMID:28396429 PMCID:PMC5422804
- Irimia, A., Serra, A. M., Sarkar, A., Jacak, R., Kalyuzhniy, O., Sok, D., Saye-Francisco, K. L., Schiffner, T., Tingle, R., Kubitz, M., Adachi, Y., Stanfield, R. L., et al. Lipid interactions and angle of approach to the HIV-1 viral membrane of broadly neutralizing antibody 10E8: Insights for vaccine and therapeutic design PLoS Pathogens 2017 13 DOI:10.1371/journal.ppat.1006212 PMID:28225819 PMCID:PMC5338832
- Magnani, D. M., Rogers, T. F., Beutler, N., Ricciardi, M. J., Bailey, V. K., Gonzalez-Nieto, L., Briney, B., Sok, D., Le, K., Strubel, A., Gutman, M. J., Pedreno-Lopez, N., et al. Neutralizing human monoclonal antibodies prevent Zika virus infection in macaques Science Translational Medicine 2017 9 DOI:10.1126/scitranslmed.aan8184 PMID:28978754
- Nandin, I. S., Fong, C., Deantonio, C., Torreno-Pina, J. A., Pecetta, S., Maldonado, P., Gasparrini, F., Ordovas-Montanes, J., Kazer, S. W., Kjaer, S., Borley, D. W., Nair, U., et al. Novel in vitro booster vaccination to rapidly generate antigen-specific human monoclonal antibodies Journal of Experimental Medicine 2017 214:2471-2490 DOI:10.1084/jem.20170633 PMID:28739603 PMCID:PMC5551578
- Magnani, D. M., Silveira, C. G. T., Ricciardi, M. J., Gonzalez-Nieto, L., Pedreno-Lopez, N., Bailey, V. K., Gutman, M. J., Maxwell, H. S., Domingues, A., Costa, P. R., Ferrari, L., Goulart, R., et al. Potent plasmablast-derived antibodies elicited by the national institutes of health dengue vaccine Journal of Virology 2017 91:e00867-17 DOI:10.1128/jvi.00867-17 PMID:28878078 PMCID:PMC5660501
- Julg, B., Liu, P. T., Wagh, K., Fischer, W. M., Abbink, P., Mercado, N. B., Whitney, J. B., Nkolola, J. P., McMahan, K., Tartaglia, L. J., Borducchi, E. N., Khatiwada, S., et al. Protection against a mixed SHIV challenge by a broadly neutralizing antibody cocktail Science Translational Medicine 2017 9 DOI:10.1126/scitranslmed.aao4235 PMID:28931655
- Julg, B., Sok, D., Schmidt, S. D., Abbink, P., Newman, R. M., Broge, T., Linde, C., Nkolola, J., Le, K., Su, D., Torabi, J., Pack, M., et al. Protective efficacy of broadly neutralizing antibodies with incomplete neutralization activity against simian-human immunodeficiency virus in rhesus monkeys Journal of Virology 2017 91:e01187-17 DOI:10.1128/jvi.01187-17 PMID:28768869 PMCID:PMC5625479
- Sok, D., Le, K. M., Vadnais, M. L., Saye-Francisco, K. L., Jardine, J. G., Torres, J. L., Berndsen, Z. T., Kong, L., Tanfield, R. S., Ruiz, J., Ramos, A., Liang, C. H., et al. Rapid elicitation of broadly neutralizing antibodies to HIV by immunization in cows Nature 2017 548:108-111 DOI:10.1038/nature23301 PMID:28726771
- Wibmer, C. K., Gorman, J., Ozorowski, G., Bhiman, J. N., Sheward, D. J., Elliott, D. H., Rouelle, J., Smira, A., Joyce, M. G., Ndabambi, N., Druz, A., Asokan, M., et al. Structure and recognition of a novel HIV-1 gp120-gp41 interface antibody that caused MPER exposure through viral escape PLoS Pathogens 2017 13 DOI:10.1371/journal.ppat.1006074 PMID:28076415 PMCID:PMC5226681
- Kulp, D. W., Steichen, J. M., Pauthner, M., Hu, X., Schiffner, T., Liguori, A., Cottrell, C. A., Havenar-Daughton, C., Ozorowski, G., Georgeson, E., Kalyuzhniy, O., Willis, J. R., et al. Structure-based design of native-like HIV-1 envelope trimers to silence non-neutralizing epitopes and eliminate CD4 binding Nature Communications 2017 8 DOI:10.1038/s41467-017-01549-6 PMID:29162799 PMCID:PMC5698488
- Xu, L., Pegu, A., Rao, E., Doria-Rose, N., Beninga, J., McKee, K., Lord, D. M., Wei, R. R., Deng, G. J., Louder, M., Schmidt, S. D., Mankoff, Z., et al. Trispecific broadly neutralizing HIV antibodies mediate potent SHIV protection in macaques Science 2017 358:85-89 DOI:10.1126/science.aan8630 PMID:28931639
- Martins, M. A., Shin, Y. C., Gonzalez-Nieto, L., Domingues, A., Gutman, M. J., Maxwell, H. S., Castro, I., Magnani, D. M., Ricciardi, M., Pedreno-Lopez, N., Bailey, V., Betancourt, D., et al. Vaccine-induced immune responses against both Gag and Env improve control of simian immunodeficiency virus replication in rectally challenged rhesus macaques PLoS Pathogens 2017 13 DOI:10.1371/journal.ppat.1006529 PMID:28732035 PMCID:PMC5540612
- Burton, D. R. What are the most powerful immunogen design vaccine strategies? Reverse vaccinology 2.0 shows great promise Cold Spring Harbor Perspectives in Biology 2017 9 DOI:10.1101/cshperspect.a030262 PMID:28159875 PMCID:PMC5540812
- Rogers, T. F., Goodwin, E. C., Briney, B., Sok, D., Beutler, N., Strubel, A., Nedellec, R., Le, K., Brown, M. E., Burton, D. R., Walker, L. M. Zika virus activates de novo and cross-reactive memory B cell responses in dengue-experienced donors Science Immunology 2017 2 DOI:10.1126/sciimmunol.aan6809 PMID:28821561 PMCID:PMC5892203
- Sok, D., Pauthner, M., Briney, B., Lee, J. H., Saye-Francisco, K. L., Hsueh, J., Ramos, A., Le, K. M., Jones, M., Jardine, J. G., Bastidas, R., Sarkar, A., et al. A prominent site of antibody vulnerability on HIV envelope incorporates a motif associated with CCR5 binding and its camouflaging glycans Immunity 2016 45:31-45 DOI:10.1016/j.immuni.2016.06.026 PMID:27438765 PMCID:PMC4990068
- van Gils, M. J., van den Kerkhof, T. L., Ozorowski, G., Cottrell, C. A., Sok, D., Pauthner, M., Pallesen, J., de Val, N., Yasmeen, A., de Taeye, S. W., Schorcht, A., Gumbs, S., et al. An HIV-1 antibody from an elite neutralizer implicates the fusion peptide as a site of vulnerability Nature Microbiology 2016 2 DOI:10.1038/nmicrobiol.2016.199 PMID:27841852 PMCID:PMC5372380
- Larrick, J. W., Alfenito, M. R., Scott, J. K., Parren, P. W. H. I., Burton, D. R., Bradbury, A. R. M., Lemere, C. A., Messer, A., Huston, J. S., Carter, P. J., Veldman, T., Chester, K. A., et al. Antibody Engineering & Therapeutics 2016: The Antibody Society's annual meeting, December 11-15, 2016, San Diego, CA MAbs 2016 8:1425-1434 DOI:10.1080/19420862.2016.1227665 PMID:27557809
- Liu, J., Ghneim, K., Sok, D., Bosche, W. J., Li, Y., Chipriano, E., Berkemeier, B., Oswald, K., Borducchi, E., Cabral, C., Peter, L., Brinkman, A., et al. Antibody-mediated protection against SHIV challenge includes systemic clearance of distal virus Science 2016 353:1045-1049 DOI:10.1126/science.aag0491 PMID:27540005
- Burton, D. R., Hangartner, L. Broadly neutralizing antibodies to HIV and their role in vaccine design Annual Review of Immunology 2016 34:635-659 DOI:10.1146/annurev-immunol-041015-055515 PMID:27168247
- Briney, B., Le, K., Zhu, J., Burton, D. R. Clonify: unseeded antibody lineage assignment from next-generation sequencing data Scientific Reports 2016 6 DOI:10.1038/srep23901 PMID:27102563 PMCID:PMC4840318
- von Bredow, B., Arias, J. F., Heyer, L. N., Moldt, B., Le, K., Robinson, J. E., Zolla-Pazner, S., Burton, D. R., Evans, D. T. Comparison of antibody-dependent cell-mediated cytotoxicity and virus neutralization by HIV-1 Env-specific monoclonal antibodies Journal of Virology 2016 90:6127-6139 DOI:10.1128/jvi.00347-16 PMID:27122574 PMCID:PMC4907221
- Behrens, A. J., Vasiljevic, S., Pritchard, L. K., Harvey, D. J., Andev, R. S., Krumm, S. A., Struwe, W. B., Cupo, A., Kumar, A., Zitzmann, N., Seabright, G. E., Kramer, H. B., et al. Composition and antigenic effects of individual glycan sites of a trimeric HIV-1 envelope glycoprotein Cell Reports 2016 14:2695-2706 DOI:10.1016/j.celrep.2016.02.058 PMID:26972002 PMCID:PMC4805854
- Havenar-Daughton, C., Carnathan, D. G., Torrents de la Peña, A., Pauthner, M., Briney, B., Reiss, S. M., Wood, J. S., Kaushik, K., van Gils, M. J., Rosales, S. L., van der Woude, P., Locci, M., et al. Direct probing of germinal center responses reveals immunological features and bottlenecks for neutralizing antibody responses to HIV Env trimer Cell Reports 2016 17:2195-2209 DOI:10.1016/j.celrep.2016.10.085 PMID:27880897 PMCID:PMC5142765
- MacLeod, D. T., Choi, N. M., Briney, B., Garces, F., Ver, L. S., Landais, E., Murrell, B., Wrin, T., Kilembe, W., Liang, C. H., Ramos, A., Bian, C. B., et al. Early antibody lineage diversification and independent limb maturation lead to broad HIV-1 neutralization targeting the Env high-mannose patch Immunity 2016 44:1215-1226 DOI:10.1016/j.immuni.2016.04.016 PMID:27192579 PMCID:PMC5003182
- Kong, R., Xu, K., Zhou, T., Acharya, P., Lemmin, T., Liu, K., Ozorowski, G., Soto, C., Taft, J. D., Bailer, R. T., Cale, E. M., Chen, L., et al. Fusion peptide of HIV-1 as a site of vulnerability to neutralizing antibody Science 2016 352:828-833 DOI:10.1126/science.aae0474 PMID:27174988 PMCID:PMC4917739
- Sok, D., Burton, D. R. HIV broadly neutralizing antibodies: taking good care of the 98% Immunity 2016 45:958-960 DOI:10.1016/j.immuni.2016.10.033 PMID:27851923
- Steichen, J. M., Kulp, D. W., Tokatlian, T., Escolano, A., Dosenovic, P., Stanfield, R. L., McCoy, L. E., Ozorowski, G., Hu, X., Kalyuzhniy, O., Briney, B., Schiffner, T., et al. HIV vaccine design to target germline precursors of glycan-dependent broadly neutralizing antibodies Immunity 2016 45:483-496 DOI:10.1016/j.immuni.2016.08.016 PMID:27617678 PMCID:PMC5040827
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- Parren, Pwhi, Marx, P. A., Hessell, A. J., Luckay, A., Harouse, J., Cheng-Mayer, C., Moore, J. P., Burton, D. R. Antibody protects macaques against vaginal challenge with a pathogenic r5 simian/human immunodeficiency virus at serum levels giving complete neutralization in vitro Journal of Virology 2001 75:8340-8347 DOI:10.1128/jvi.75.17.8340-8347.2001 PMID:11483779
- Schaller, M., Burton, D. R., Ditzel, H. J. Autoantibodies to gpi in rheumatoid arthritis: Linkage between an animal model and human disease Nature Immunology 2001 2:746-753 DOI:10.1038/90696 PMID:11477412
- Zwick, M. B., Labrijn, A. F., Wang, M., Spenlehauer, C., Saphire, E. O., Binley, J. M., Moore, J. P., Stiegler, G., Katinger, H., Burton, D. R., Parren, P. W. Broadly neutralizing antibodies targeted to the membrane-proximal external region of human immunodeficiency virus type 1 glycoprotein gp41 Journal of Virology 2001 75:10892-10905 DOI:10.1128/jvi.75.22.10892-10905.2001 PMID:11602729 PMCID:PMC114669
- Matsunaga, Y., Peretz, D., Williamson, A., Burton, D., Mehlhorn, I., Groth, D., Cohen, F. E., Prusiner, S. B., Baldwin, M. A. Cryptic epitopes in n-terminally truncated prion protein are exposed in the full-length molecule: Dependence of conformation on ph Proteins-Structure Function and Bioinformatics 2001 44:110-118 DOI:10.1002/prot.1077 PMID:11391773
- Saphire, E. O., Parren, P. W. H. I., Pantophlet, R., Zwick, M. B., Morris, G. M., Rudd, P. M., Dwek, R. A., Stanfield, R. L., Burton, D. R., Wilson, I. A. Crystal structure of a neutralizing human IGG against HIV-1: a template for vaccine design Science 2001 293:1155-1159 DOI:10.1126/science.1061692 PMID:11498595
- Saphire, E. O., Parren, P. W., Barbas, C. F., 3rd, Burton, D. R., Wilson, I. A. Crystallization and preliminary structure determination of an intact human immunoglobulin, b12: An antibody that broadly neutralizes primary isolates of HIV-1 Acta Crystallographica Section D-Biological Crystallography 2001 57:168-171 DOI:10.1107/s0907444900017376 PMID:11134947
- Carrasco, B., de la Torre, J. G., Davis, K. G., Jones, S., Athwal, D., Walters, C., Burton, D. R., Harding, S. E. Crystallohydrodynamics for solving the hydration problem for multi-domain proteins: Open physiological conformations for human IgG Biophysical Chemistry 2001 93:181-196 DOI:10.1016/s0301-4622(01)00220-4 PMID:11804725
- Moore, J. P., Parren, Pwhi, Burton, D. R. Genetic subtypes, humoral immunity, and human immunodeficiency virus type 1 vaccine development Journal of Virology 2001 75:5721-5729 DOI:10.1128/jvi.75.13.5721-5729.2001 PMID:11390574
- Poignard, P., Saphire, E. O., Parren, P. W. H. I., Burton, D. R. Gp120: Biologic aspects of structural features Annual Review of Immunology 2001 19:253-274 DOI:10.1146/annurev.immunol.19.1.253 PMID:11244037
- Zwick, M. B., Bonnycastle, L. L. C., Menendez, A., Irving, M. B., Barbas, C. F., Parren, Pwhi, Burton, D. R., Scott, J. K. Identification and characterization of a peptide that specifically binds the human, broadly neutralizing anti-human immunodeficiency virus type 1 antibody b12 Journal of Virology 2001 75:6692-6699 DOI:10.1128/jvi.75.14.6692-6699.2001 PMID:11413337
- Leclerc, E., Peretz, D., Ball, H., Sakurai, H., Legname, G., Serban, A., Prusiner, S. B., Burton, D. R., Williamson, R. A. Immobilized prion protein undergoes spontaneous rearrangement to a conformation having features in common with the infectious form EMBO Journal 2001 20:1547-1554 DOI:10.1093/emboj/20.7.1547 PMID:11285219 PMCID:PMC145482
- Gilden, D. H., Burgoon, M. P., Kleinschmidt-DeMasters, B. K., Williamson, R. A., Ghausi, O., Burton, D. R., Owens, G. P. Molecular immunologic strategies to identify antigens and b-cell responses unique to multiple sclerosis Archives of Neurology 2001 58:43-48 DOI:10.1001/archneur.58.1.43 PMID:11176935
- Bugli, F., Bastidas, R., Burton, D. R., Williamson, R. A., Clementi, M., Burioni, R. Molecular profile of a human monoclonal antibody fab fragment specific for epstein-barr virus gp350/220 antigen Human Immunology 2001 62:362-367 DOI:10.1016/s0198-8859(01)00216-6 PMID:11295468
- Zwick, M. B., Wang, M., Poignard, P., Stiegler, G., Katinger, H., Burton, D. R., Parren, Pwhi Neutralization synergy of human immunodeficiency virus type 1 primary isolates by cocktails of broadly neutralizing antibodies Journal of Virology 2001 75:12198-12208 DOI:10.1128/jvi.75.24.12198-12208.2001 PMID:11711611
- Xu, W. D., Smith-Franklin, B. A., Li, P. L., Wood, C., He, J., Du, Q. J., Bhat, G. J., Kankasa, C., Katinger, H., Cavacini, L. A., Posner, M. R., Burton, D. R., et al. Potent neutralization of primary human immunodeficiency virus clade c isolates with a synergistic combination of human monoclonal antibodies raised against clade b Journal of Human Virology 2001 4:55-61 PMID:11437315
- Burton, D. R. Shots in the dark: The wayward search for an aids vaccine Nature 2001 414:251-252 DOI:10.1038/35104670
- Peretz, D., Scott, M. R., Groth, D., Williamson, R. A., Burton, D. R., Cohen, F. E., Prusiner, S. B. Strain-specified relative conformational stability of the scrapie prion protein Protein Science 2001 10:854-863 DOI:10.1110/ps.39201 PMID:11274476 PMCID:PMC2373967
- Parren, Pwhi, Burton, D. R. The antiviral activity of antibodies in vitro and in vivo Advances in Immunology 2001 77:195-262 DOI:10.1016/s0065-2776(01)77018-6 PMID:11293117
- Dorrell, L., Hessell, A. J., Wang, M., Whittle, H., Sabally, S., Rowland-Jones, S., Burton, D. R., Parren, Pwhi Absence of specific mucosal antibody responses in hiv-exposed uninfected sex workers from the gambia AIDS 2000 14:1117-1122 DOI:10.1097/00002030-200006160-00008 PMID:10894275
- Parren, Pwhi, Poignard, P., Ditzel, H. J., Williamson, R. A., Burton, D. R. Antibodies in human infectious disease Immunologic Research 2000 21:265-278 DOI:10.1385/ir:21:2-3:265 PMID:10852127
- Burton, D. R., Williamson, R. A., Parren, Pwhi Antibody and virus: Binding and neutralization Virology 2000 270:1-3 DOI:10.1006/viro.2000.0239 PMID:10772973
- Ditzel, H. J., Masaki, Y., Nielsen, H., Farnaes, L., Burton, D. R. Cloning and expression of a novel human antibody-antigen pair associated with felty's syndrome Proceedings of the National Academy of Sciences of the United States of America 2000 97:9234-9239 DOI:10.1073/pnas.97.16.9234 PMID:10922075
- Owens, G. P., Williamson, R. A., Burgoon, M. P., Ghausi, O., Burton, D. R., Gilden, D. H. Cloning the antibody response in humans with chronic inflammatory disease: Immunopanning of subacute sclerosing panencephalitis (sspe) brain sections with antibody phage libraries prepared from sspe brain enriches for antibody recognizing measles virus antigens in situ Journal of Virology 2000 74:1533-1537 DOI:10.1128/jvi.74.3.1533-1537.2000 PMID:10627565
- Wong, B. S., Venien-Bryan, C., Williamson, R. A., Burton, D. R., Gambetti, P., Sy, M. S., Brown, D. R., Jones, I. M. Copper refolding of prion protein Biochemical and Biophysical Research Communications 2000 276:1217-1224 DOI:10.1006/bbrc.2000.3604 PMID:11027613
- Wang, H., Griffiths, M. N., Burton, D. R., Ghazal, P. Rapid antibody responses by low-dose, single-step, dendritic cell-targeted immunization Proceedings of the National Academy of Sciences of the United States of America 2000 97:847-852 DOI:10.1073/pnas.97.2.847 PMID:10639168
- Sanna, P. P., Burton, D. R. Role of antibodies in controlling viral disease: lessons from experiments of nature and gene knockouts Journal of Virology 2000 74:9813-9817 DOI:10.1128/jvi.74.21.9813-9817.2000 PMID:11024107 PMCID:PMC102017
- Kanyo, Z. F., Pan, K. M., Williamson, R. A., Burton, D. R., Prusiner, S. B., Fletterick, R. J., Cohen, F. E. Antibody binding defines a structure for an epitope that participates in the prpc -> prpsc conformational change Journal of Molecular Biology 1999 293:855-863 DOI:10.1006/jmbi.1999.3193 PMID:10543972
- Crawford, J. M., Earl, P. L., Moss, B., Reimann, K. A., Wyand, M. S., Manson, K. H., Bilska, M., Zhou, J. T., Pauza, C. D., Parren, Pwhi, Burton, D. R., Sodroski, J. G., et al. Characterization of primary isolate-like variants of simian-human immunodeficiency virus Journal of Virology 1999 73:10199-10207 PMID:10559336 PMCID:PMC113073
- Burgoon, M. P., Williamson, R. A., Owens, G. P., Ghausi, O., Bastidas, R. B., Burton, D. R., Gilden, D. H. Cloning the antibody response in humans with inflammatory cns disease: Isolation of measles virus-specific antibodies from phage display libraries of a subacute sclerosing panencephalitis brain Journal of Neuroimmunology 1999 94:204-211 DOI:10.1016/s0165-5728(98)00243-4 PMID:10376954
- Maruyama, T., Rodriguez, L. L., Jahrling, P. B., Sanchez, A., Khan, A. S., Nichol, S. T., Peters, C. J., Parren, Pwhi, Burton, D. R. Ebola virus can be effectively neutralized by antibody produced in natural human infection Journal of Virology 1999 73:6024-6030 PMID:10364354 PMCID:PMC112663
- Sakurai, H., Williamson, R. A., Crowe, J. E., Beeler, J. A., Poignard, P., Bastidas, R. B., Chanock, R. M., Burton, D. R. Human antibody responses to mature and immature forms of viral envelope in respiratory syncytial virus infection: Significance for subunit vaccines Journal of Virology 1999 73:2956-2962 PMID:10074145 PMCID:PMC104055
- Maruyama, T., Parren, Pwhi, Sanchez, A., Rensink, I., Rodriguez, L. L., Khan, A. S., Peters, C. J., Burton, D. R. Recombinant human monoclonal antibodies to ebola virus Journal of Infectious Diseases 1999 179:S235-S239 DOI:10.1086/514280 PMID:9988189
- Parren, Pwhi, Moore, J. P., Burton, D. R., Sattentau, Q. J. The neutralizing antibody response to hiv-1: Viral evasion and escape from humoral immunity AIDS 1999 13:S137-S162 PMID:10885772
- Sanna, P. P., Samson, M. E., Moon, J. S., Rozenshteyn, R., De Logu, A., Williamson, R. A., Burton, D. R. pFab-CMV, a single vector system for the rapid conversion of recombinant Fabs into whole IgG1 antibodies Immunotechnology 1999 4:185-188 DOI:10.1016/s1380-2933(98)00022-0 PMID:10231088
- Parren, Pwhi, Wang, M., Trkola, A., Binley, J. M., Purtscher, M., Katinger, H., Moore, J. P., Burton, D. R. Antibody neutralization-resistant primary isolates of human immunodeficiency virus type 1 Journal of Virology 1998 72:10270-10274 PMID:9811774 PMCID:PMC110612
- De Logu, A., Williamson, R. A., Rozenshteyn, R., Ramiro-Ibanez, F., Simpson, C. D., Burton, D. R., Sanna, P. P. Characterization of a type-common human recombinant monoclonal antibody to herpes simplex virus with high therapeutic potential Journal of Clinical Microbiology 1998 36:3198-3204 PMID:9774565 PMCID:PMC105301
- Sullivan, N., Sun, Y., Binley, J., Lee, J., Barbas, C. F., Parren, Pwhi, Burton, D. R., Sodroski, J. Determinants of human immunodeficiency virus type 1 envelope glycoprotein activation by soluble cd4 and monoclonal antibodies Journal of Virology 1998 72:6332-6338 PMID:9658072 PMCID:PMC109776
- Salonen, E. M., Parren, Pwhi, Graus, Y. F., Lundkvist, A., Fisicaro, P., Vapalahti, O., Kallio-Kokko, H., Vaheri, A., Burton, D. R. Human recombinant puumala virus antibodies: Cross-reaction with other hantaviruses and use in diagnostics Journal of General Virology 1998 79:659-665 PMID:9568958
- Williamson, R. A., Peretz, D., Pinilla, C., Ball, H., Bastidas, R. B., Rozenshteyn, R., Houghten, R. A., Prusiner, S. B., Burton, D. R. Mapping the prion protein using recombinant antibodies Journal of Virology 1998 72:9413-9418 PMID:9765500 PMCID:PMC110372
- Crowe, J. E., Firestone, C. Y., Crim, R., Beeler, J. A., Coelingh, K. L., Barbas, C. F., Burton, D. R., Chanock, R. M., Murphy, B. R. Monoclonal antibody-resistant mutants selected with a respiratory syncytial virus-neutralizing human antibody fab fragment (fab 19) define a unique epitope on the fusion (f) glycoprotein Virology 1998 252:373-375 DOI:10.1006/viro.1998.9462 PMID:9878616
- Parren, Pwhi, Mondor, I., Naniche, D., Ditzel, H. J., Klasse, P. J., Burton, D. R., Sattentau, Q. J. Neutralization of human immunodeficiency virus type 1 by antibody to gp120 is determined primarily by occupancy of sites on the virion irrespective of epitope specificity Journal of Virology 1998 72:3512-3519 PMID:9557629 PMCID:PMC109569
- Frankel, S. S., Steinman, R. M., Michael, N. L., Kim, S. R., Bhardwaj, N., Pope, M., Louder, M. K., Ehrenberg, P. K., Parren, Pwhi, Burton, D. R., Katinger, H., VanCott, T. C., et al. Neutralizing monoclonal antibodies block human immunodeficiency virus type 1 infection of dendritic cells and transmission to t cells Journal of Virology 1998 72:9788-9794 PMID:9811714 PMCID:PMC110490
- LeBlanc, J. F., McLane, K. E., Parren, Pwhi, Burton, D. R., Ghazal, P. Recognition properties of a sequence-specific DNA binding antibody Biochemistry 1998 37:6015-6022 DOI:10.1021/bi9730792 PMID:9558339
- Graus, Y. F., Verschuuren, J. J., Degenhardt, A., Vriesman, P. J. V., De Baets, M. H., Posner, J. B., Burton, D. R., Dalmau, J. Selection of recombinant anti-hud fab fragments from a phage display antibody library of a lung cancer patient with paraneoplastic encephalomyelitis Journal of Neuroimmunology 1998 82:200-209 DOI:10.1016/s0165-5728(97)00199-9 PMID:9585817
- Glamann, J., Burton, D. R., Parren, Pwhi, Ditzel, H. J., Kent, K. A., Arnold, C., Montefiori, D., Hirsch, V. M. Simian immunodeficiency virus (siv) envelope-specific fabs with high-level homologous neutralizing activity: Recovery from a long-term-nonprogressor siv-infected macaque Journal of Virology 1998 72:585-592 PMID:9420262 PMCID:PMC109411
- Ditzel, H. J., Rosenkilde, M. M., Garred, P., Wang, M., Koefoed, K., Pedersen, C., Burton, D. R., Schwartz, T. W. The ccr5 receptor acts as an alloantigen in ccr5 delta 32 homozygous individuals: Identification of chemokine- and hiv-1-blocking human antibodies Proceedings of the National Academy of Sciences of the United States of America 1998 95:5241-5245 DOI:10.1073/pnas.95.9.5241 PMID:9560260
- Peretz, D., Williamson, R. A., Matsunaga, Y., Serban, H., Pinilla, C., Bastidas, R. B., Rozenshteyn, R., James, T. L., Houghten, R. A., Cohen, F. E., Prusiner, S. B., Burton, D. R. A conformational transition at the n terminus of the prion protein features in formation of the scrapie isoform Journal of Molecular Biology 1997 273:614-622 DOI:10.1006/jmbi.1997.1328 PMID:9356250
- Burton, D. R. A vaccine for hiv type 1: The antibody perspective Proceedings of the National Academy of Sciences of the United States of America 1997 94:10018-10023 DOI:10.1073/pnas.94.19.10018 PMID:9294155
- Graus, Y. F., deBaets, M. H., Vriesman, P. J. V., Burton, D. R. Anti-acetylcholine receptor fab fragments isolated from thymus-derived phage display libraries from myasthenia gravis patients reflect predominant specificities in serum and block the action of pathogenic serum antibodies Immunology Letters 1997 57:59-62 DOI:10.1016/s0165-2478(97)00046-1 PMID:9232426
- Parren, Pwhi, Burton, D. R. Antibodies against hiv-1 from phage display libraries: Mapping of an immune response and progress towards antiviral immunotherapy Antibody Engineering 1997 65:18-56 PMID:9018871
- Cattani, P., Rossolini, G. M., Cresti, S., Santangelo, R., Burton, D. R., Williamson, R. A., Sanna, P. P., Fadda, G. Detection and typing of herpes simplex viruses by using recombinant immunoglobulin fragments produced in bacteria Journal of Clinical Microbiology 1997 35:1504-1509 PMID:9163470 PMCID:PMC229775
- Graus, Y. F., deBaets, M. H., Parren, Pwhi, Berrih-Aknin, S., Wokke, J., Vriesman, P. J. V., Burton, D. R. Human anti-nicotinic acetylcholine receptor recombinant fab fragments isolated from thymus-derived phage display libraries from myasthenia gravis patients reflect predominant specificities in serum and block the action of pathogenic serum antibodies Journal of Immunology 1997 158:1919-1929 PMID:9029134
- Mo, H. M., Stamatatos, L., Ip, J. E., Barbas, C. F., Parren, Pwhi, Burton, D. R., Moore, J. P., Ho, D. D. Human immunodeficiency virus type 1 mutants that escape neutralization by human monoclonal antibody igg1b12 Journal of Virology 1997 71:6869-6874 PMID:9261412 PMCID:PMC191968
- Ugolini, S., Mondor, I., Parren, Pwhi, Burton, D. R., Tilley, S. A., Klasse, P. J., Sattentau, Q. J. Inhibition of virus attachment to cd4(+) target cells is a major mechanism of t cell line-adapted hiv-1 neutralization Journal of Experimental Medicine 1997 186:1287-1298 DOI:10.1084/jem.186.8.1287 PMID:9334368
- Ditzel, H. J., Parren, Pwhi, Binley, J. M., Sodroski, J., Moore, J. P., Barbas, C. F., Burton, D. R. Mapping the protein surface of human immunodeficiency virus type 1 gp120 using human monoclonal antibodies from phage display libraries Journal of Molecular Biology 1997 267:684-695 DOI:10.1006/jmbi.1997.0912 PMID:9126846
- Gauduin, M. C., Parren, Pwhi, Weir, R., Barbas, C. F., Burton, D. R., Koup, R. A. Passive immunization with a human monoclonal antibody protects hu-pbl-scid mice against challenge by primary isolates of hiv-1 Nature Medicine 1997 3:1389-1393 DOI:10.1038/nm1297-1389 PMID:9396610
- Kessler, J. A., McKenna, P. M., Emini, E. A., Chan, C. P., Patel, M. D., Gupta, S. K., Mark, G. E., Barbas, C. F., Burton, D. R., Conley, A. J. Recombinant human monoclonal antibody igg1b12 neutralizes diverse human immunodeficiency virus type 1 primary isolates AIDS Research and Human Retroviruses 1997 13:575-582 DOI:10.1089/aid.1997.13.575 PMID:9135875
- Parren, Pwhi, Gauduin, M. C., Koup, R. A., Poignard, P., Fisicaro, P., Burton, D. R., Sattentau, Q. J. Relevance of the antibody response against human immunodeficiency virus type 1 envelope to vaccine design Immunology Letters 1997 57:105-112 DOI:10.1016/s0165-2478(97)00043-6 PMID:9232434
- Baba, T. W., Sodroski, J., ZollaPazner, S., Gorny, M. K., Robinson, J., Posner, M. R., Katinger, H., Barbas, C. F., Burton, D. R., Chou, T. C., Ruprecht, R. M., Li, A. Synergistic neutralization of a chimeric SIV/HIV type 1 virus with combinations of human anti-HIV type 1 envelope monoclonal antibodies or hyperimmune globulins AIDS Research and Human Retroviruses 1997 13:647-656 DOI:10.1089/aid.1997.13.647 PMID:9168233
- Burton, D. R., Montefiori, D. C. The antibody response in HIV-1 infection AIDS 1997 11:S87-S98 PMID:9451972
- Williamson, R. A., Lazzarotto, T., Sanna, P. P., Bastidas, R. B., Casa, B. D., Campisi, G., Burioni, R., Landini, M. P., Burton, D. R. Use of recombinant human antibody fragments for detection of cytomegalovirus antigenemia Journal of Clinical Microbiology 1997 35:2047-2050 PMID:9230379 PMCID:PMC229900
- Seligman, S. J., Binley, J. M., Gorny, M. K., Burton, D. R., ZollaPazner, S., Sokolowski, K. A. Characterization by serial deletion competition elisas of hiv-1 v3 loop epitopes recognized by monoclonal antibodies Molecular Immunology 1996 33:737-745 DOI:10.1016/0161-5890(96)00044-2 PMID:8811069
- Williamson, R. A., Peretz, D., Smorodinsky, N., Bastidas, R., Serban, H., Mehlhorn, I., DeArmond, S. J., Prusiner, S. B., Burton, D. R. Circumventing tolerance to generate autologous monoclonal antibodies to the prion protein Proceedings of the National Academy of Sciences of the United States of America 1996 93:7279-7282 DOI:10.1073/pnas.93.14.7279 PMID:8692983
- Ditzel, H. J., Itoh, K., Burton, D. R. Determinants of polyreactivity in a large panel of recombinant human antibodies from hiv-1 infection Journal of Immunology 1996 157:739-749 PMID:8752924
- Gauduin, M. C., Allaway, G. P., Maddon, P. J., Barbas, C. F., Burton, D. R., Koup, R. A. Effective ex vivo neutralization of human immunodeficiency virus type 1 in plasma by recombinant immunoglobulin molecules Journal of Virology 1996 70:2586-2592 PMID:8642690 PMCID:PMC190106
- Binley, J. M., Ditzel, H. J., Barbas, C. F., Sullivan, N., Sodroski, J., Parren, Pwhi, Burton, D. R. Human antibody responses to hiv type 1 glycoprotein 41 cloned in phage display libraries suggest three major epitopes are recognized and give evidence for conserved antibody motifs in antigen binding AIDS Research and Human Retroviruses 1996 12:911-924 DOI:10.1089/aid.1996.12.911 PMID:8798976
- Parren, Pwhi, Fisicaro, P., Labrijn, A. F., Binley, J. M., Yang, W. P., Ditzel, H. J., Barbas, C. F., Burton, D. R. In vitro antigen challenge of human antibody libraries for vaccine evaluation: The human immunodeficiency virus type 1 envelope Journal of Virology 1996 70:9046-9050 PMID:8971041 PMCID:PMC191009
- Sanna, P. P., deLogu, A., Williamson, R. A., Hom, Y. L., Straus, S. E., Bloom, F. E., Burton, D. R. Protection of nude mice by passive immunization with a type-common human recombinant monoclonal antibody against hsv Virology 1996 215:101-106 DOI:10.1006/viro.1996.0011 PMID:8553581
- Barbas, C. F., Burton, D. R. Selection and evolution of high-affinity human anti-viral antibodies Trends in Biotechnology 1996 14:230-234 DOI:10.1016/0167-7799(96)10029-9 PMID:8771795
- McKenzie, I. F. C., Osman, N., Cohney, S., Vaughan, H. A., Patton, K., Mouhtouris, E., Atkin, J. D., Elliott, E., Fodor, W. L., Squinto, S. P., Burton, D., Gallop, M. A., et al. Strategies to overcome the anti-gal alpha(1-3)gal reaction in xenotransplantation Transplantation Proceedings 1996 28:537-537 PMID:8623253
- Zeitlin, L., Whaley, K. J., Sanna, P. P., Moench, T. R., Bastidas, R., DeLogu, A., Williamson, R. A., Burton, D. R., Cone, R. A. Topically applied human recombinant monoclonal igg(1) antibody and its fab and f(ab')(2) fragments protect mice from vaginal transmission of hsv-2 Virology 1996 225:213-215 DOI:10.1006/viro.1996.0589 PMID:8918548
- Yang, W. P., Green, K., Pinzsweeney, S., Briones, A. T., Burton, D. R., Barbas, C. F. Cdr walking mutagenesis for the affinity maturation of a potent human anti-hiv-1 antibody into the picomolar range Journal of Molecular Biology 1995 254:392-403 DOI:10.1006/jmbi.1995.0626 PMID:7490758
- Trkola, A., Pomales, A. B., Yuan, H., Korber, B., Maddon, P. J., Allaway, G. P., Katinger, H., Barbas, C. F., Burton, D. R., Ho, D. D., Moore, J. P. Cross-clade neutralization of primary isolates of human immunodeficiency virus type 1 by human monoclonal antibodies and tetrameric CD4-IgG Journal of Virology 1995 69:6609-6617 PMID:7474069 PMCID:PMC189569
- Sanna, P. P., Williamson, R. A., Delogu, A., Bloom, F. E., Burton, D. R. Directed selection of recombinant human monoclonal-antibodies to herpes-simplex virus glycoproteins from phage display libraries Proceedings of the National Academy of Sciences of the United States of America 1995 92:6439-6443 DOI:10.1073/pnas.92.14.6439 PMID:7604009
- Barbas, S. M., Ditzel, H. J., Salonen, E. M., Yang, W. P., Silverman, G. J., Burton, D. R. Human autoantibody recognition of DNA Proceedings of the National Academy of Sciences of the United States of America 1995 92:2529-2533 DOI:10.1073/pnas.92.7.2529 PMID:7708679
- Dealboran, I. M., Martinezalonso, C., Barbas, C. F., Burton, D. R., Ditzel, H. J. Human monoclonal fab fragments specific for viral-antigens from combinatorial iga libraries Immunotechnology 1995 1:21-28 DOI:10.1016/1380-2933(95)00002-x PMID:9373330
- Ditzel, H. J., Binley, J. M., Moore, J. P., Sodroski, J., Sullivan, N., Sawyer, L. S. W., Hendry, R. M., Yang, W. P., Barbas, C. F., Burton, D. R. Neutralizing recombinant human-antibodies to a conformational v2-binding and cd4-binding site-sensitive epitope of hiv-1 gp120 isolated by using an epitope-masking procedure Journal of Immunology 1995 154:893-906 PMID:7529290
- Burton, D. R. Phage display Immunotechnology 1995 1:87-94 DOI:10.1016/1380-2933(95)00013-5 PMID:9373337
- Moore, J. P., Cao, Y. Z., Qing, L., Sattentau, Q. J., Pyati, J., Koduri, R., Robinson, J., Barbas, C. F., Burton, D. R., Ho, D. D. Primary isolates of human-immunodeficiency-virus type-1 are relatively resistant to neutralization by monoclonal-antibodies to gp120, and their neutralization is not predicted by studies with monomeric gp120 Journal of Virology 1995 69:101-109 PMID:7527081 PMCID:PMC188553
- Parren, Pwhi, Ditzel, H. J., Gulizia, R. J., Binley, J. M., Barbas, C. F., Burton, D. R., Mosier, D. E. Protection against HIV-1 infection in hu-PBL-SCID mice by passive immunization with a neutralizing human monoclonal antibody against the gp120 CD4-binding site AIDS 1995 9:F1-F6 PMID:7662189
- Sanna, P. P., Delogu, A., Williamson, R. A., Samson, M. E., Altieri, D. C., Bloom, F. E., Burton, D. R. Rapid assay of phage-derived recombinant human Fabs as bispecific antibodies Bio-Technology 1995 13:1221-1224 DOI:10.1038/nbt1195-1221 PMID:9636296
- McLane, K. E., Burton, D. R., Ghazal, P. Transplantation of a 17-amino acid alpha-helical DNA-binding domain into an antibody molecule confers sequence-dependent DNA recognition Proceedings of the National Academy of Sciences of the United States of America 1995 92:5214-5218 DOI:10.1073/pnas.92.11.5214 PMID:7761476
- Hexham, J. M., Partridge, L. J., Furmaniak, J., Petersen, V. B., Colls, J. C., Pegg, C., Rees, S. B., Burton, D. R. Cloning and characterization of tpo autoantibodies using combinatorial phage display libraries Autoimmunity 1994 17:167-179 PMID:7524700
- Burton, D. R., Pyati, J., Koduri, R., Sharp, S. J., Thornton, G. B., Parren, Pwhi, Sawyer, L. S. W., Hendry, R. M., Dunlop, N., Nara, P. L., Lamacchia, M., Garratty, E., et al. Efficient neutralization of primary isolates of hiv-1 by a recombinant human monoclonal-antibody Science 1994 266:1024-1027 DOI:10.1126/science.7973652 PMID:7973652
- Pease, J. E., Burton, D. R., Barker, M. D. Generation of chimeric c5a/formyl peptide receptors - towards the identification of the human c5a receptor-binding site European Journal of Immunology 1994 24:211-215 DOI:10.1002/eji.1830240133 PMID:8020557
- Burton, D. R., Barbas, C. F. Human monoclonal antibodies: Recent achievements Hospital Practice 1994 29:111, 114-116, 119 passim PMID:7962228
- Burton, D. R., Barbas, C. F. Human-antibodies from combinatorial libraries Advances in Immunology 1994 57:191-280 DOI:10.1016/s0065-2776(08)60674-4 PMID:7872158
- Barbas, C. F., Hu, D., Dunlop, N., Sawyer, L., Cababa, D., Hendry, R. M., Nara, P. L., Burton, D. R. In-vitro evolution of a neutralizing human-antibody to human-immunodeficiency-virus type-1 to enhance affinity and broaden strain cross-reactivity Proceedings of the National Academy of Sciences of the United States of America 1994 91:3809-3813 PMID:8170992 PMCID:PMC43671
- Barbas, S. M., Ghazal, P., Barbas, C. F., Burton, D. R. Recognition of DNA by synthetic antibodies Journal of the American Chemical Society 1994 116:2161-2162 DOI:10.1021/ja00084a073
- Roben, P., Moore, J. P., Thali, M., Sodroski, J., Barbas, C. F., Burton, D. R. Recognition properties of a panel of human recombinant fab fragments to the cd4 binding-site of gp120 that show differing abilities to neutralize human-immunodeficiency-virus type-1 Journal of Virology 1994 68:4821-4828 PMID:7518527 PMCID:PMC236421
- Burioni, R., Williamson, R. A., Sanna, P. P., Bloom, F. E., Burton, D. R. Recombinant human fab to glycoprotein-d neutralizes infectivity and prevents cell-to-cell transmission of herpes-simplex virus-1 and virus-2 in-vitro Proceedings of the National Academy of Sciences of the United States of America 1994 91:355-359 DOI:10.1073/pnas.91.1.355 PMID:8278393
- Crowe, J. E., Murphy, B. R., Chanock, R. M., Williamson, R. A., Barbas, C. F., Burton, D. R. Recombinant human respiratory syncytial virus (rsv) monoclonal-antibody fab is effective therapeutically when introduced directly into the lungs of rsv-infected mice Proceedings of the National Academy of Sciences of the United States of America 1994 91:1386-1390 DOI:10.1073/pnas.91.4.1386 PMID:8108420
- Pease, J. E., Burton, D. R., Barker, M. D. Site-directed mutagenesis of the complement c5a receptor - examination of a model for its interaction with the ligand c5a Molecular Immunology 1994 31:733-737 DOI:10.1016/0161-5890(94)90147-3 PMID:8035835
- Ditzel, H. J., Barbas, S. M., Barbas, C. F., Burton, D. R. The nature of the autoimmune antibody repertoire in human-immunodeficiency-virus type-1 infection Proceedings of the National Academy of Sciences of the United States of America 1994 91:3710-3714 DOI:10.1073/pnas.91.9.3710 PMID:8170974
- Prusiner, S. B., Groth, D., Serban, A., Koehler, R., Foster, D., Torchia, M., Burton, D., Yang, S. L., Dearmond, S. J. Ablation of the prion protein (prp) gene in mice prevents scrapie and facilitates production of anti-prp antibodies Proceedings of the National Academy of Sciences of the United States of America 1993 90:10608-10612 DOI:10.1073/pnas.90.22.10608 PMID:7902565
- Williamson, R. A., Burioni, R., Sanna, P. P., Partridge, L. J., Barbas, C. F., Burton, D. R. Human monoclonal-antibodies against a plethora of viral pathogens from single combinatorial libraries Proceedings of the National Academy of Sciences of the United States of America 1993 90:4141-4145 DOI:10.1073/pnas.90.9.4141 PMID:7683424
- Chanock, R. M., Crowe, J. E., Murphy, B. R., Burton, D. R. Human monoclonal-antibody fab fragments cloned from combinatorial libraries - potential usefulness in prevention and/or treatment of major human viral diseases Infectious Agents and Disease-Reviews Issues and Commentary 1993 2:118-131 PMID:8173784
- Burton, D. R., Barbas, C. F. Human-antibodies to hiv-1 by recombinant-DNA methods Chemical Immunology 1993 56:112-126 PMID:8452652
- Soultanas, P., Andrews, P. D., Burton, D. R., Hornby, D. P. Modulation of human DNA methyltransferase activity and messenger-rna levels in the monoblast cell-line u937 induced to differentiate with dibutyryl-cyclic-amp and phorbol ester Journal of Molecular Endocrinology 1993 11:191-200 PMID:8297475
- Barbas, C. F., Collet, T. A., Amberg, W., Roben, P., Binley, J. M., Hoekstra, D., Cababa, D., Jones, T. M., Williamson, R. A., Pilkington, G. R., Haigwood, N. L., Cabezas, E., et al. Molecular profile of an antibody-response to hiv-1 as probed by combinatorial libraries Journal of Molecular Biology 1993 230:812-823 DOI:10.1006/jmbi.1993.1203 PMID:8478936
- Sasano, M., Burton, D. R., Silverman, G. J. Molecular-selection of human-antibodies with an unconventional bacterial b-cell antigen Journal of Immunology 1993 151:5822-5839 PMID:8228264
- Burton, D. R. Monoclonal antibodies from combinatorial libraries Accounts of Chemical Research 1993 26:405-411 DOI:10.1021/ar00032a003
- Pease, J. E., Burton, D. R., Barker, M. D. The generation of stable cho-cell lines expressing very high-levels of complement c5a receptors and subsequent modulation of binding-affinity for c5a Biochemistry and Molecular Biology International 1993 29:339-347 PMID:8495216
- Collet, T. A., Roben, P., Okennedy, R., Barbas, C. F., Burton, D. R., Lerner, R. A. A binary plasmid system for shuffling combinatorial antibody libraries Proceedings of the National Academy of Sciences of the United States of America 1992 89:10026-10030 DOI:10.1073/pnas.89.21.10026 PMID:1438192
- Hexham, J. M., Furmaniak, J., Pegg, C., Burton, D. R., Smith, B. R. Cloning of a human autoimmune-response - preparation and sequencing of a human antithyroglobulin autoantibody using a combinatorial approach Autoimmunity 1992 12:135-141 DOI:10.3109/08916939209150320 PMID:1617110
- Burton, D. R., Woof, J. M. Human antibody effector function Advances in Immunology 1992 51:1-84 DOI:10.1016/s0065-2776(08)60486-1 PMID:1502974
- Zebedee, S. L., Barbas, C. F., Hom, Y. L., Caothien, R. H., Graff, R., Degraw, J., Pyati, J., Lapolla, R., Burton, D. R., Lerner, R. A., Thornton, G. B. Human combinatorial antibody libraries to hepatitis-b surface-antigen Proceedings of the National Academy of Sciences of the United States of America 1992 89:3175-3179 DOI:10.1073/pnas.89.8.3175 PMID:1373487
- Burton, D. R. Human monoclonal antibodies: achievement and potential Hospital Practice 1992 27:67-74
- Barbas, C. F., Crowe, J. E., Cababa, D., Jones, T. M., Zebedee, S. L., Murphy, B. R., Chanock, R. M., Burton, D. R. Human monoclonal fab fragments derived from a combinatorial library bind to respiratory syncytial virus-f glycoprotein and neutralize infectivity Proceedings of the National Academy of Sciences of the United States of America 1992 89:10164-10168 PMID:1279672 PMCID:PMC50298
- Duchosal, M. A., Eming, S. A., Fischer, P., Leturcq, D., Barbas, C. F., McConahey, P. J., Caothien, R. H., Thornton, G. B., Dixon, F. J., Burton, D. R. Immunization of hu-pbl-scid mice and the rescue of human monoclonal fab fragments through combinatorial libraries Nature 1992 355:258-262 DOI:10.1038/355258a0 PMID:1731222
- Barbas, C. F., Bjorling, E., Chiodi, F., Dunlop, N., Cababa, D., Jones, T. M., Zebedee, S. L., Persson, M. A. A., Nara, P. L., Norrby, E., Burton, D. R. Recombinant human fab fragments neutralize human type-1 immunodeficiency virus in vitro Proceedings of the National Academy of Sciences of the United States of America 1992 89:9339-9343 PMID:1384050 PMCID:PMC50122
- Burton, D. R., Barbas, C. F., Persson, M. A. A., Koenig, S., Chanock, R. M., Lerner, R. A. A large array of human monoclonal-antibodies to type-1 human-immunodeficiency-virus from combinatorial libraries of asymptomatic seropositive individuals Proceedings of the National Academy of Sciences of the United States of America 1991 88:10134-10137 DOI:10.1073/pnas.88.22.10134 PMID:1719545
- Kang, A. S., Jones, T. M., Burton, D. R. Antibody redesign by chain shuffling from random combinatorial immunoglobulin libraries Proceedings of the National Academy of Sciences of the United States of America 1991 88:11120-11123 DOI:10.1073/pnas.88.24.11120 PMID:1763028
- Blackburn, G. M., Kingsbury, G., Jayaweera, S., Burton, D. R. Expanded transition-state analogs Ciba Foundation Symposia 1991 159:211-226 PMID:1959449
- Williamson, R. A., Persson, M. A. A., Burton, D. R. Expression of a human monoclonal anti-(rhesus-d) fab fragment in escherichia-coli with the use of bacteriophage-lambda vectors Biochemical Journal 1991 277:561-563 PMID:1830475 PMCID:PMC1151271
- Persson, M. A. A., Caothien, R. H., Burton, D. R. Generation of diverse high-affinity human monoclonal-antibodies by repertoire cloning Proceedings of the National Academy of Sciences of the United States of America 1991 88:2432-2436 DOI:10.1073/pnas.88.6.2432 PMID:1826052
- Burton, D. R. Human and mouse monoclonal-antibodies by repertoire cloning Trends in Biotechnology 1991 9:169-175 DOI:10.1016/0167-7799(91)90055-m PMID:1367284
- Lund, J., Winter, G., Jones, P. T., Pound, J. D., Tanaka, T., Walker, M. R., Artymiuk, P. J., Arata, Y., Burton, D. R., Jefferis, R., Woof, J. M. Human fc-gamma-ri and fc-gamma-rii interact with distinct but overlapping sites on human-igg Journal of Immunology 1991 147:2657-2662 PMID:1833457
- Lerner, R. A., Barbas, C. F., Kang, A. S., Burton, D. R. On the use of combinatorial antibody libraries to clone the fossil record of an individuals immune-response Proceedings of the National Academy of Sciences of the United States of America 1991 88:9705-9706 DOI:10.1073/pnas.88.21.9705 PMID:1946391
- Sheth, B., Banks, P., Burton, D. R., Monk, P. N. The regulation of actin polymerization in differentiating u937 cells correlates with increased membrane levels of the pertussis-toxin-sensitive g-protein gi2 Biochemical Journal 1991 275:809-811 PMID:1645523 PMCID:PMC1150128
- Davis, K. G., Glennie, M., Harding, S. E., Burton, D. R. A model for the solution conformation of rat ige Biochemical Society Transactions 1990 18:935-936 PMID:2083747
- Burton, D. R. Antibody - the flexible adapter molecule Trends in Biochemical Sciences 1990 15:64-69 DOI:10.1016/0968-0004(90)90178-e PMID:2186517
- Kang, A. S., Kingsbury, G. A., Blackburn, G. M., Burton, D. R. Catalytic antibodies - designer enzymes Chemistry in Britain 1990 26:128-132
- Blackburn, G. M., Kingsbury, G. A., Burton, D. R. Catalytic antibodies Biochemical Journal 1989 262:381-390 PMID:2679548 PMCID:PMC1133279
- Burton, D., Artymiuk, P., Ford, G. Death by antibody New Scientist 1989 122:42-45
- Huse, W. D., Sastry, L., Iverson, S. A., Kang, A. S., Altingmees, M., Burton, D. R., Benkovic, S. J., Lerner, R. A. Generation of a large combinatorial library of the immunoglobulin repertoire in phage-lambda Science 1989 246:1275-1281 DOI:10.1126/science.2531466 PMID:2531466
- Walker, M. R., Woof, J. M., Bruggemann, M., Jefferis, R., Burton, D. R. Interaction of human-igg chimeric antibodies with the human fcri and fcrii receptors - requirements for antibody-mediated host-cell target-cell interaction Molecular Immunology 1989 26:403-411 DOI:10.1016/0161-5890(89)90129-6 PMID:2716734
- Dransfield, I., Corcoran, D., Partridge, L. J., Hogg, N., Burton, D. R. Comparison of human-monocytes isolated by elutriation and adherence suggests that heterogeneity may reflect a continuum of maturation activation states Immunology 1988 63:491-498 PMID:3350583 PMCID:PMC1454750
- Sheth, B., Dransfield, I., Partridge, L. J., Barker, M. D., Burton, D. R. Dibutyryl cyclic-amp stimulation of a monocyte-like cell-line, u937 - a model for monocyte chemotaxis and fc receptor-related functions Immunology 1988 63:483-490 PMID:2832314 PMCID:PMC1454775
- Walker, M. R., Kumpel, B. M., Thompson, K., Woof, J. M., Burton, D. R., Jefferis, R. Immunogenic and antigenic epitopes of immunoglobulins binding of human monoclonal anti-d antibodies to fcri on the monocyte-like u937 cell-line Vox Sanguinis 1988 55:222-228 PMID:2464239
- Duncan, A. R., Woof, J. M., Partridge, L. J., Burton, D. R., Winter, G. Localization of the binding-site for the human high-affinity fc receptor on igg Nature 1988 332:563-564 DOI:10.1038/332563a0 PMID:2965792
- Woof, J. M., Burton, D. R. Microassay for measurement of binding of radiolabeled ligands to cell-surface molecules Journal of Immunological Methods 1988 111:205-207 DOI:10.1016/0022-1759(88)90128-7 PMID:2840465
- Burton, D. R., Jefferis, R., Partridge, L. J., Woof, J. M. Molecular recognition of antibody (igg) by cellular fc receptor (fcri) Molecular Immunology 1988 25:1175-1181 DOI:10.1016/0161-5890(88)90153-8 PMID:2975762
- Burton, D. R. Molecular-basis of antibody effector function Biochemical Society Transactions 1988 16:953-956 PMID:3224761
- Banks, P., Barker, M. D., Burton, D. R. Recruitment of actin to the cytoskeletons of human monocyte-like cells activated by complement fragment-c5a - is protein kinase-c involved Biochemical Journal 1988 252:765-769 PMID:3421921 PMCID:PMC1149213
- Gregory, L., Davis, K. G., Sheth, B., Boyd, J., Jefferis, R., Nave, C., Burton, D. R. The solution conformations of the subclasses of human-igg deduced from sedimentation and small-angle x-ray-scattering studies Molecular Immunology 1987 24:821-829 DOI:10.1016/0161-5890(87)90184-2 PMID:3657808
- Burton, D. R., Gregory, L., Jefferis, R. Aspects of the molecular-structure of igg subclasses Monographs in Allergy 1986 19:7-35 PMID:2945094
- Burton, D. R. Is igm-like dislocation a common feature of antibody function Immunology Today 1986 7:165-167 DOI:10.1016/0167-5699(86)90166-0 PMID:25290200
- Woof, J. M., Partridge, L. J., Jefferis, R., Burton, D. R. Localization of the monocyte-binding region on human immunoglobulin-g Molecular Immunology 1986 23:319-330 DOI:10.1016/0161-5890(86)90059-3 PMID:3487030
- Barker, M. D., Jose, P. J., Williams, T. J., Burton, D. R. The chemoattractant des-arg74-c5a regulates the expression of its own receptor on a monocyte-like cell-line Biochemical Journal 1986 236:621-624 PMID:3019322
- Partridge, L. J., Woof, J. M., Jefferis, R., Burton, D. R. The use of anti-igg monoclonal-antibodies in mapping the monocyte receptor-site on igg Molecular Immunology 1986 23:1365-1372 DOI:10.1016/0161-5890(86)90022-2 PMID:2434846
- Leatherbarrow, R. J., Rademacher, T. W., Dwek, R. A., Woof, J. M., Clark, A., Burton, D. R., Richardson, N., Feinstein, A. Effector functions of a monoclonal aglycosylated mouse igg2a - binding and activation of complement component c1 and interaction with human monocyte fc-receptor Molecular Immunology 1985 22:407-415 DOI:10.1016/0161-5890(85)90125-7 PMID:4033665
- Burton, D. R. Immunoglobulin-g - functional sites Molecular Immunology 1985 22:161-206 DOI:10.1016/0161-5890(85)90151-8 PMID:3889592
- Perkins, S. J., Villiers, C. L., Arlaud, G. J., Boyd, J., Burton, D. R., Colomb, M. G., Dwek, R. A. Neutron-scattering studies of subcomponent clq of 1st component cl of human-complement and its association with subunit clr2cls2 within cl Journal of Molecular Biology 1984 179:547-557 DOI:10.1016/0022-2836(84)90079-2 PMID:6096553
- Woof, J. M., Jaafar, M. I. N., Jefferis, R., Burton, D. R. The monocyte binding domain(s) on human immunoglobulin-g Molecular Immunology 1984 21:523-527 DOI:10.1016/0161-5890(84)90068-3 PMID:6235444
- Boyd, J., Burton, D. R., Perkins, S. J., Villiers, C. L., Dwek, R. A., Arlaud, G. J. Neutron-scattering studies of the isolated c1r2c1s2 subunit of 1st component of human-complement in solution Proceedings of the National Academy of Sciences of the United States of America 1983 80:3769-3773 DOI:10.1073/pnas.80.12.3769 PMID:6304736
- Emanuel, E. J., Brampton, A. D., Burton, D. R., Dwek, R. A. Formation of complement subcomponent c1q immunoglobulin-g complex - thermodynamic and chemical-modification studies Biochemical Journal 1982 205:361-372 PMID:6982707 PMCID:PMC1158489
- Isaksson-Forsen, G., Elgjo, K., Burton, D., Iversen, O. H. Partial purification of the epidermal G2 chalone based on an in vivo assay system Cell Biology International Reports 1981 5:195-199 DOI:10.1016/0309-1651(81)90028-x PMID:6452953
- Burton, D. R., Forsen, S., Reimarsson, P. The interaction of polyamines with DNA - a na-23 NMR-study Nucleic Acids Research 1981 9:1219-1228 DOI:10.1093/nar/9.5.1219 PMID:7232215
- Burton, D. R., Boyd, J., Brampton, A. D., Easterbrooksmith, S. B., Emanuel, E. J., Novotny, J., Rademacher, T. W., Vanschravendijk, M. R., Sternberg, M. J. E., Dwek, R. A. The c1q receptor-site on immunoglobulin-g Nature 1980 288:338-344 DOI:10.1038/288338a0 PMID:6776418
- Burton, D. R., Forsen, S., Karlstrom, G., Dwek, R. A. Proton relaxation enhancement (pre) in biochemistry - critical survey Progress in Nuclear Magnetic Resonance Spectroscopy 1979 13:1-45 DOI:10.1016/0079-6565(79)80012-6
- Burton, D. R., Forsen, S., Franek, F., Novotny, J. Proton relaxation enhancement to probe the effects of antigen-binding on pig antibody structure FEBS Letters 1979 102:249-252 DOI:10.1016/0014-5793(79)80011-3 PMID:88375
- Burton, D. R., Butler, M. J., Hyde, J. E., Phillips, D., Skidmore, C. J., Walker, I. O. Interaction of core histones with DNA - equilibrium binding studies Nucleic Acids Research 1978 5:3643-3663 DOI:10.1093/nar/5.10.3643 PMID:724497
- Burton, D. R., Reimarsson, P. Na-23 NMR as a probe of ion binding to chromatin FEBS Letters 1978 89:183-186 DOI:10.1016/0014-5793(78)80213-0 PMID:658406
- Korsgaard, R., Iversen, O. H., Isaksson-Forsen, G., Burton, D. R. Specificity of epidermal chalone extracts for human epidermoid tumour cells in vitro: a preliminary report Cell and Tissue Kinetics 1978 11:441-443 DOI:10.1111/j.1365-2184.1978.tb00816.x PMID:150948
- Burton, D. R., Forsen, S., Karlstrom, G., Dwek, R. A., McLaughlin, A. C., Wainhobson, S. Determination of molecular-motion parameters from proton-relaxation-enhancement measurements in a number of gd(iii) antibody-fragment complexes - comparative-study European Journal of Biochemistry 1977 75:445-453 DOI:10.1111/j.1432-1033.1977.tb11547.x PMID:560299
- Wright, C., Willan, K. J., Sjodahl, J., Burton, D. R., Dwek, R. A. Interaction of protein-a and fc-fragment of rabbit immunoglobulin-g as probed by complement-fixation and NMR-studies Biochemical Journal 1977 167:661-668 PMID:603628 PMCID:PMC1183712
- Burton, D. R., Dwek, R. A., Forsen, S., Karlstrom, G. Novel-approach to water proton relaxation in paramagnetic ion macromolecule complexes Biochemistry 1977 16:250-254 DOI:10.1021/bi00621a014 PMID:836785
- Isaksson-Forsen, G., Burton, D. R., Korsgaard, R., Elgjo, K., Iversen, O. H. Partial purification of epidermal G2 chalone Virchows Archiv B-Cell Pathology Including Molecular Pathology 1977 26:97-103 PMID:146951
- Korsgaard, R., Iversen, O. H., Burton, D. R., Isaksson-Forsen, G. [Species-non-specific and reversible growth inhibition by chalones in human epidermoid carcinomas in vitro] Zeitschrift für Krebsforschung und Klinische Onkologie 1977 88:217-221 DOI:10.1007/bf00305359 PMID:140538
- Burton, D. R., Forsen, S., Karlstrom, G., Dwek, R. A., McLaughlin, A. C., Wainhobson, S. Difficulties in determining accurate molecular-motion parameters from proton relaxation enhancement measurements as illustrated by immunoglobulin-g . Gd(iii) system European Journal of Biochemistry 1976 71:519-528 DOI:10.1111/j.1432-1033.1976.tb11140.x PMID:188653
- Burton, D. R., Hyde, J. E., Walker, I. O. Histones f2a1 and f3 interact reversibly and cooperatively with DNA to form an equimolar complex in chromatin FEBS Letters 1975 55:77-80 DOI:10.1016/0014-5793(75)80962-8 PMID:1170100
-
chapter
- Calarese, D., Scanlan, C., Lee, H. K., Rudd, P., Dwek, R. Toward a carbohydrate-based HIV-1 vaccine ACS Symposium Series. 161-185. 2006 DOI:10.1021/bk-2006-0932.ch007
editor of
-
book
- Barbas III, C., Burton, D., Scott, J. K., Silverman, G. J., eds. Phage display : a laboratory manual Cold Spring Harbor, NY: Cold Spring Harbor Laboratory Press. 2001
featured in
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- TSRI Named ‘Top Institution’ in HIV/AIDS Research; Dennis Burton, ‘Hot Researcher’ Newsletter
Affiliation
head of
- IAVI Neutralizing Antibody Center Director
Research
research overview
-
Antibodies and Infectious Disease
The perception of man as the easy victor over microbes has changed dramatically in the last two decades. Vaccination has offered protection against a number of viral pathogens, but it is increasingly recognized that the strategies used in the past will not be successful against all viruses. More understanding of viral pathogenesis and the interaction of viruses with the immune system is required. We are focused on the interplay of antibodies and viruses in humans, and it particular, the highly mutable viruses, human immunodeficiency virus type 1 (HIV-1) and hepatitis C virus (HCV). We have developed broadly neutralizing antibodies to these viruses to explore the anti-viral activity of antibodies in vitro and in vivo and to define molecular targets for rational vaccine design.
Teaching
advisees
-
graduate advising relationship
- Altman, Pilar , Ph.D. candidate, 2018 -
- Joyce, Collin Matthew, Ph.D. candidate, 2018 -
- Song, Ge, Ph.D. candidate, 2017 -
- Zhao, Fangzhu, Ph.D. candidate, 2018 -
- Pauthner, Matthias, Ph.D. candidate, 2013 - 2017
- Wold, Erik, Ph.D. candidate, 2010 - 2015
- Sok, Devin, Ph.D. candidate, 2009 - 2014
- Walker, Laura, Ph.D. candidate, 2008 - 2011
- Astronomo, Rena, Ph.D. candidate, 2004 - 2009
- Scherer, Erin, Ph.D. candidate, 2004 - 2009
- Bowley, Diana, Ph.D. candidate, 2002 - 2007
- Gakhal, Amandeep Dhillon , Ph.D. candidate, 2003 - 2007
- Barbas-Frederickson, Shana, Ph.D. candidate, 1990 - 1995
Background
education and training
- Ph.D. in Physical Biochemistry, Lund University 1978
- B.A. in Chemistry, University of Oxford , Oxon 1st Class 1974
Contact
full name
- Dennis R. Burton
geographic location
Identity
eRA Commons ID
- Dennis_R_Burton