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Burton, Dennis
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Burton, Dennis

Faculty Member
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Positions

  • 2017 - Co-Chair, Immunology and Microbiology , Scripps Research
  • 2017 - Professor, Immunology and Microbiology , Scripps Research
  • 2015 - James and Jessie Minor Chair in Immunology, Scripps Research
  • 2012 - Director, Center for HIV/AIDS Vaccine Immunology and Immunogen Discovery (CHAVI-ID)
  • 2012 - Immunologist,, Massachusetts General Hospital
  • 2008 - Visiting Professor, Oxford Centre in Virology, University of Oxford
  • 2002 - Director, IAVI Neutralizing Antibody Center
  • 1991 - Faculty Member, Skaggs Graduate School of Chemical and Biological Sciences , Scripps Research
  • Faculty Member and Program Leader, Ragon Institute of MGH, MIT and Harvard
  • 2015 - 2017 Chairman, Immunology and Microbial Science (IMS) , Scripps Research
  • 1991 - 2017 Professor, Immunology and Microbial Science (IMS) , Scripps Research
  • 2015 Distinguished Lecturer, The American Association of Immunologists
  • - 2012 Professor (Joint Appointment), Molecular Biology , Scripps Research
  • 1990 - 1991 Personal Chair, The University of Sheffield
  • 1989 - 1991 Visiting Member, Research Institute of Scripps Clinic
  • 1985 - 1991 Jenner Fellow, Lister Institute of Preventive Medicine
  • 1987 - 1990 Senior Lecturer in Biochemistry, The University of Sheffield
  • 1981 - 1987 Lecturer in Biochemistry, The University of Sheffield
  • 1980 - 1981 Junior Research Fellow, Wolfson College, University of Oxford
  • 1979 - 1981 Medical Research Council Training Fellowship, University of Oxford
Dr. Dennis Burton focuses his research primarily on human antibody responses to HIV and the design of an HIV vaccine. He has also worked on the interaction of antibodies and other pathogens, including respiratory syncytial virus, Ebola virus and prion proteins.

Research Areas research areas

  • Hepatitis C (UMLS)

Contact

  • burton@scripps.edu

Websites

  • Dennis Burton, Ph.D.
  • Burton Laboratory
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Publications

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  • 138

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  • academic article

    • Burton, D. R., Topol, E. J. Toward superhuman SARS-CoV-2 immunity? Nature Medicine  2021 27:5-6  DOI:10.1038/s41591-020-01180-x  PMID:33257892
    • Wec, A. Z., Wrapp, D., Herbert, A. S., Maurer, D. P., Haslwanter, D., Sakharkar, M., Jangra, R. K., Dieterle, M. E., Lilov, A., Huang, D. L., Tse, L. V., Johnson, N. V., et al. Broad neutralization of SARS-related viruses by human monoclonal antibodies Science  2020 369:731-736  DOI:10.1126/science.abc7424  PMID:32540900  PMCID:PMC7299279
    • Carnathan, D. G., Kaushik, K., Ellebedy, A. H., Enemuo, C. A., Gebru, E. H., Dhadvai, P., Rasheed, M. A. U., Pauthner, M. G., Ozorowski, G., Ahmed, R., Burton, D. R., Ward, A. B., et al. Harnessing Activin A Adjuvanticity to Promote Antibody Responses to BG505 HIV Envelope Trimers Frontiers in Immunology  2020 11  DOI:10.3389/fimmu.2020.01213  PMID:32612608  PMCID:PMC7308430
    • Nogal, B., McCoy, L. E., van Gils, M. J., Cottrell, C. A., Voss, J. E., Andrabi, R., Pauthner, M., Liang, C. H., Messmer, T., Nedellec, R., Shin, M., Turner, H. L., et al. HIV envelope trimer-elicited autologous neutralizing antibodies bind a region overlapping the N332 glycan supersite Science Advances  2020 6  DOI:10.1126/sciadv.aba0512  PMID:32548265  PMCID:PMC7274786
    • Burton, D. R., Walker, L. M. Rational Vaccine Design in the Time of COVID-19 Cell Host & Microbe  2020 27:695-698  DOI:10.1016/j.chom.2020.04.022  PMID:32407707  PMCID:PMC7219357
    • Yang, Y. H. R., McCoy, L. E., van Gils, M. J., Andrabi, R., Turner, H. L., Yuan, M., Cottrell, C. A., Ozorowski, G., Voss, J., Pauthner, M., Polveroni, T. M., Messmer, T., et al. Autologous antibody responses to an HIV envelope glycan hole are not easily broadened in rabbits Journal of Virology  2020 94  DOI:10.1128/jvi.01861-19  PMID:31941772  PMCID:PMC7081899
    • Nogal, B., Bianchi, M., Cottrell, C. A., Kirchdoerfer, R. N., Sewall, L. M., Turner, H. L., Zhao, F., Sok, D., Burton, D. R., Hangartner, L., Ward, A. B. Mapping polyclonal antibody responses in non-human primates vaccinated with HIV env trimer subunit vaccines Cell Reports  2020 30:3755-3765  DOI:10.1016/j.celrep.2020.02.061  PMID:32187547  PMCID:PMC7153566
    • Pedreno-Lopez, N., Dang, C. M., Rosen, B. C., Ricciardi, M. J., Bailey, V. K., Gutman, M. J., Gonzalez-Nieto, L., Pauthner, M. G., Le, K., Song, G., Andrabi, R., Weisgrau, K. L., et al. Induction of transient virus replication facilitates antigen-independent isolation of SIV-specific monoclonal antibodies Molecular Therapy-Methods & Clinical Development  2020 16:225-237  DOI:10.1016/j.omtm.2020.01.010  PMID:32083148  PMCID:PMC7021589
    • Moyer, T. J., Kato, Y., Abraham, W., Chang, J. Y. H., Kulp, D. W., Watson, N., Turner, H. L., Menis, S., Abbott, R. K., Bhiman, J. N., Melo, M. B., Simon, H. A., et al. Engineered immunogen binding to alum adjuvant enhances humoral immunity Nature Medicine  2020 26:430-440  DOI:10.1038/s41591-020-0753-3  PMID:32066977  PMCID:PMC7069805
    • Pedreno-Lopez, N., Ricciardi, M. J., Rosen, B. C., Song, G., Andrabi, R., Burton, D. R., Rakasz, E. G., Watkins, D. I. An Automated Fluorescence-Based Method to Isolate Bone Marrow-Derived Plasma Cells from Rhesus Macaques Using SIVmac239 SOSIP.664 Molecular Therapy-Methods & Clinical Development  2020 18:781-790  DOI:10.1016/j.omtm.2020.08.004  PMID:32953929  PMCID:PMC7476808
    • Saif, L. J., Burton, D., Saphire, E. O., Scangos, G., Georgiou, G., Gerngross, T., Glanville, J. COVID-19 antibodies on trial Nature Biotechnology  2020 38:1242-1252  DOI:10.1038/s41587-020-0732-8  PMID:33087898  PMCID:PMC7576980
    • Joyce, C., Burton, D. R., Briney, B. Comparisons of the antibody repertoires of a humanized rodent and humans by high throughput sequencing Scientific Reports  2020 10  DOI:10.1038/s41598-020-57764-7  PMID:31980672  PMCID:PMC6981180
    • Rogers, T. F., Zhao, F., Huang, D. L., Beutler, N., Burns, A., He, W. T., Limbo, O., Smith, C., Song, G., Woehl, J., Yang, L. L., Abbott, R. K., et al. Isolation of potent SARS-CoV-2 neutralizing antibodies and protection from disease in a small animal model Science  2020 369:956-963  DOI:10.1126/science.abc7520  PMID:32540903  PMCID:PMC7299280
    • Zhao, F., Joyce, C., Burns, A., Nogal, B., Cottrell, C. A., Ramos, A., Biddle, T., Pauthner, M., Nedellec, R., Qureshi, H., Mason, R., Landais, E., et al. Mapping Neutralizing Antibody Epitope Specificities to an HIV Env Trimer in Immunized and in Infected Rhesus Macaques Cell Reports  2020 32  DOI:10.1016/j.celrep.2020.108122  PMID:32905766  PMCID:PMC7487785
    • Cottrell, C. A., van Schooten, J., Bowman, C. A., Yuan, M., Oyen, D., Shin, M., Morpurgo, R., van der Woude, P., van Breemen, M., Torres, J. L., Patel, R., Gross, J., et al. Mapping the immunogenic landscape of near-native HIV-1 envelope trimers in non-human primates PLoS Pathogens  2020 16  DOI:10.1371/journal.ppat.1008753  PMID:32866207  PMCID:PMC7485981
    • Yuan, M., Liu, H. J., Wu, N. C., Lee, C. C. D., Zhu, X. Y., Zhao, F., Huang, D. L., Yu, W. L., Hua, Y. Z., Tien, H., Rogers, T. F., Landais, E., et al. Structural basis of a shared antibody response to SARS-CoV-2 Science  2020 369:1119-1123  DOI:10.1126/science.abd2321  PMID:32661058  PMCID:PMC7402627
    • Ben-Othman, R., Cai, B., Liu, A. R. C., Varankovich, N., He, D. I., Blimkie, T. M., Lee, A. H., Gill, E. E., Novotny, M., Aevermann, B., Drissler, S., Shannon, C. P., et al. Systems Biology Methods Applied to Blood and Tissue for a Comprehensive Analysis of Immune Response to Hepatitis B Vaccine in Adults Frontiers in Immunology  2020 11  DOI:10.3389/fimmu.2020.580373  PMID:33250895  PMCID:PMC7672042
    • Steichen, J. M., Lin, Y. C., Havenar-Daughton, C., Pecetta, S., Ozorowski, G., Willis, J. R., Toy, L., Sok, D., Liguori, A., Kratochvil, S., Torres, J. L., Kalyuzhniy, O., et al. A generalized HIV vaccine design strategy for priming of broadly neutralizing antibody responses Science  2019 366  DOI:10.1126/science.aax4380  PMID:31672916
    • Zhang, L., Irimia, A., He, L., Landais, E., Rantalainen, K., Leaman, D. P., Vollbrecht, T., Stano, A., Sands, D. I., Kim, A. S., Poignard, P., Burton, D. R., et al. An MPER antibody neutralizes HIV-1 using germline features shared among donors Nature Communications  2019 10  DOI:10.1038/s41467-019-12973-1  PMID:31772165  PMCID:PMC6879610
    • Havenar-Daughton, C., Carnathan, D. G., Boopathy, A. V., Upadhyay, A. A., Murrell, B., Reiss, S. M., Enemuo, C. A., Gebru, E. H., Choe, Y., Dhadvai, P., Viviano, F., Kaushik, K., et al. Rapid germinal center and antibody responses in non-human primates after a single nanoparticle vaccine immunization Cell Reports  2019 29:1756-+  DOI:10.1016/j.celrep.2019.10.008  PMID:31722194
    • Haynes, B. F., Burton, D. R., Mascola, J. R. Multiple roles for HIV broadly neutralizing antibodies Science Translational Medicine  2019 11  DOI:10.1126/scitranslmed.aaz2686  PMID:31666399
    • Burton, D. R. Antibody barriers to going viral Journal of Experimental Medicine  2019 216:2226-2228  DOI:10.1084/jem.20191099  PMID:31444247  PMCID:PMC6781000
    • Pegu, A., Borate, B., Huang, Y., Pauthner, M. G., Hessell, A. J., Julg, B., Doria-Rose, N. A., Schmidt, S. D., Carpp, L. N., Cully, M. D., Chen, X., Shaw, G. M., et al. A meta-analysis of passive immunization studies shows that serum-neutralizing antibody titer associates with protection against SHIV challenge Cell Host & Microbe  2019 26:336-346  DOI:10.1016/j.chom.2019.08.014  PMID:31513771  PMCID:PMC6755677
    • Umotoy, J., Bagaya, B. S., Joyce, C., Schiffner, T., Menis, S., Saye-Francisco, K. L., Biddle, T., Mohan, S., Vollbrecht, T., Kalyuzhniy, O., Madzorera, S., Kitchin, D., et al. Rapid and Focused Maturation of a VRC01-Class HIV Broadly Neutralizing Antibody Lineage Involves Both Binding and Accommodation of the N276-Glycan Immunity  2019 51:141-154  DOI:10.1016/j.immuni.2019.06.004  PMID:31315032  PMCID:PMC6642152
    • von Bredow, B., Andrabi, R., Grunst, M., Grandea, A. G., Le, K., Song, G., Berndsen, Z. T., Porter, K., Pallesen, J., Ward, A. B., Burton, D. R., Evans, D. T. Differences in the binding affinity of an HIV-1 V2 apex-specific antibody for the SIVsmm/mac envelope glycoprotein uncouple antibody-dependent cellular cytotoxicity from neutralization Mbio  2019 10:e01255-19  DOI:10.1128/mBio.01255-19  PMID:31266872  PMCID:PMC6606807
    • Seabright, G. E., Doores, K. J., Burton, D. R., Crispin, M. Protein and glycan mimicry in HIV vaccine design Journal of Molecular Biology  2019 431:2223-2247  DOI:10.1016/j.jmb.2019.04.016  PMID:31028779  PMCID:PMC6556556
    • Andrabi, R., Pallesen, J., Allen, J. D., Song, G., Zhang, J., de Val, N., Gegg, G., Porter, K., Su, C., Pauthner, M., Newman, A., Bouton-Verville, H., et al. The chimpanzee SIV envelope trimer: structure and deployment as an HIV vaccine template Cell Reports  2019 27:2426-2441  DOI:10.1016/j.celrep.2019.04.082  PMID:31116986  PMCID:PMC6533203
    • Cirelli, K. M., Carnathan, D. G., Nogal, B., Martin, J. T., Rodriguez, O. L., Upadhyay, A. A., Enemuo, C. A., Gebru, E. H., Choe, Y., Viviano, F., Nakao, C., Pauthner, M. G., et al. Slow delivery immunization enhances HIV neutralizing antibody and germinal center responses via modulation of immunodominance Cell  2019 177:1153-1171  DOI:10.1016/j.cell.2019.04.012  PMID:31080066
    • Briney, B., Inderbitzin, A., Joyce, C., Burton, D. R. Commonality despite exceptional diversity in the baseline human antibody repertoire Nature  2019 566:393-397  DOI:10.1038/s41586-019-0879-y  PMID:30664748
    • Burton, D. R. Advancing an HIV vaccine; advancing vaccinology Nature Reviews Immunology  2019 19:77-78  DOI:10.1038/s41577-018-0103-6  PMID:30560910
    • Voss, J. E., Gonzalez-Martin, A., Andrabi, R., Fuller, R. P., Murrell, B., McCoy, L. E., Porter, K., Huang, D., Li, W., Sok, D., Le, K., Briney, B., et al. Reprogramming the antigen specificity of B cells using genome-editing technologies Elife  2019 8  DOI:10.7554/eLife.42995  PMID:30648968  PMCID:PMC6355199
    • Pauthner, M. G., Nkolola, J. P., Havenar-Daughton, C., Murrell, B., Reiss, S. M., Bastidas, R., Prevost, J., Nedellec, R., von Bredow, B., Abbink, P., Cottrell, C. A., Kulp, D. W., et al. Vaccine-induced protection from homologous tier 2 SHIV challenge in nonhuman primates depends on serum-neutralizing antibody titers Immunity  2019 50:241-252  DOI:10.1016/j.immuni.2018.11.011  PMID:30552025  PMCID:PMC6335502
    • Allen, E. R., Krumm, S. A., Raghwani, J., Halldorsson, S., Elliott, A., Graham, V. A., Koudriakova, E., Harlos, K., Wright, D., Warimwe, G. M., Brennan, B., Huiskonen, J. T., et al. A protective monoclonal antibody targets a site of vulnerability on the surface of Rift Valley fever virus Cell Reports  2018 25:3750-3758  DOI:10.1016/j.celrep.2018.12.001  PMID:30590046  PMCID:PMC6315105
    • He, L., Kumar, S., Allen, J. D., Huang, D. L., Lin, X., Mann, C. J., Saye-Francisco, K. L., Copps, J., Sarkar, A., Blizard, G. S., Ozorowski, G., Sok, D., et al. HIV-1 vaccine design through minimizing envelope metastability Science Advances  2018 4  DOI:10.1126/sciadv.aau6769  PMID:30474059  PMCID:PMC6248932
    • Sok, D., Burton, D. R. Recent progress in broadly neutralizing antibodies to HIV Nature Immunology  2018 19:1179-1188  DOI:10.1038/s41590-018-0235-7  PMID:30333615
    • Cao, L. W., Pauthner, M., Andrabi, R., Rantalainen, K., Berndsen, Z., Diedrich, J. K., Menis, S., Sok, D., Bastidas, R., Park, S. K. R., Delahunty, C. M., He, L., et al. Differential processing of HIV envelope glycans on the virus and soluble recombinant trimer Nature Communications  2018 9  DOI:10.1038/s41467-018-06121-4  PMID:30209313  PMCID:PMC6135743
    • Khan, S. N., Sok, D., Tran, K., Movsesyan, A., Dubrovskaya, V., Burton, D. R., Wyatt, R. T. Targeting the HIV-1 spike and coreceptor with bi- and trispecific antibodies for single-component broad inhibition of entry Journal of Virology  2018 92:e00384-18  DOI:10.1128/jvi.00384-18  PMID:29976677
    • Bianchi, M., Turner, H. L., Nogal, B., Cottrell, C. A., Oyen, D., Pauthner, M., Bastidas, R., Nedellec, R., McCoy, L. E., Wilson, I. A., Burton, D. R., Ward, A. B., et al. Electron-microscopy-based epitope mapping defines specificities of polyclonal antibodies elicited during HIV-1 BG505 envelope trimer immunization Immunity  2018 49:288-300  DOI:10.1016/j.immuni.2018.07.009  PMID:30097292  PMCID:PMC6104742
    • Saphire, E. O., Schendel, S. L., Fusco, M. L., Gangavarapu, K., Gunn, B. M., Wec, A. Z., Halfmann, P. J., Brannan, J. M., Herbert, A. S., Qiu, X. G., Wagh, K., He, S., et al. Systematic analysis of monoclonal antibodies against Ebola virus GP defines features that contribute to protection Cell  2018 174:938-952  DOI:10.1016/j.cell.2018.07.033  PMID:30096313  PMCID:PMC6102396
    • Martins, M. A., Tully, D. C., Pedreno-Lopez, N., von Bredow, B., Pauthner, M. G., Shin, Y. C., Yuan, M. L., Lima, N. S., Bean, D. J., Gonzalez-Nieto, L., Domingues, A., Gutman, M. J., et al. Mamu-B*17(+) rhesus macaques vaccinated with env, vif, and nef manifest early control of SIVmac239 replication Journal of Virology  2018 92:e00690-18  DOI:10.1128/jvi.00690-18  PMID:29875239  PMCID:PMC6069176
    • Andrabi, R., Bhiman, J. N., Burton, D. R. Strategies for a multi-stage neutralizing antibody-based HIV vaccine Current Opinion in Immunology  2018 53:143-151  DOI:10.1016/j.coi.2018.04.025  PMID:29775847  PMCID:PMC6141341
    • Cao, L., Diedrich, J. K., Ma, Y., Wang, N., Pauthner, M., Park, S. K. R., Delahunty, C. M., McLellan, J. S., Burton, D. R., Yates III, J. R., Paulson, J. C. Global site-specific analysis of glycoprotein N-glycan processing Nature Protocols  2018 13:1196-1212  DOI:10.1038/nprot.2018.024  PMID:29725121  PMCID:PMC5941933
    • Walker, L. M., Burton, D. R. Passive immunotherapy of viral infections: 'super-antibodies' enter the fray Nature Reviews Immunology  2018 18:297-308  DOI:10.1038/nri.2017.148  PMID:29379211  PMCID:PMC5918154
    • Magnani, D. M., Rogers, T. F., Maness, N. J., Grubaugh, N. D., Beutler, N., Bailey, V. K., Gonzalez-Nieto, L., Gutman, M. J., Pedreno-Lopez, N., Kwal, J. M., Ricciardi, M. J., Myers, T. A., et al. Fetal demise and failed antibody therapy during Zika virus infection of pregnant macaques Nature Communications  2018 9  DOI:10.1038/s41467-018-04056-4  PMID:29691387  PMCID:PMC5915455
    • Shivatare, V. S., Shivatare, S. S., Lee, C. C. D., Liang, C. H., Liao, K. S., Cheng, Y. Y., Saidachary, G., Wu, C. Y., Lin, N. H., Kwong, P. D., Burton, D. R., Wu, C. Y., et al. Unprecedented role of hybrid N-glycans as ligands for HIV-1 broadly neutralizing antibodies Journal of the American Chemical Society  2018 140:5202-5210  DOI:10.1021/jacs.8b00896  PMID:29578688
    • Zhou, T., Zheng, A., Baxa, U., Chuang, G. Y., Georgiev, I. S., Kong, R., O'Dell, S., Shahzad-Ul-Hussan, S., Shen, C. H., Tsybovsky, Y., Bailer, R. T., Gift, S. K., et al. A neutralizing antibody recognizing primarily N-linked glycan targets the silent face of the HIV envelope Immunity  2018 48:500-513  DOI:10.1016/j.immuni.2018.02.013  PMID:29548671
    • Wagh, K., Seaman, M. S., Zingg, M., Fitzsimons, T., Barouch, D. H., Burton, D. R., Connore, M., Ho, D. D., Mascola, J. R., Nussenzweig, M. C., Ravetch, J., Gautam, R., et al. Potential of conventional & bispecific broadly neutralizing antibodies for prevention of HIV-1 subtype A, C & D infections PLoS Pathogens  2018 14  DOI:10.1371/journal.ppat.1006860  PMID:29505593  PMCID:PMC5854441
    • Teijaro, J. R., Burton, D. R. Taking down defenses to improve vaccines Science  2018 359:277-278  DOI:10.1126/science.aar5421  PMID:29348225
    • Landais, E., Murrell, B., Briney, B., Murrell, S., Rantalainen, K., Berndsen, Z. T., Ramos, A., Wickramasinghe, L., Smith, M. L., Eren, K., de Val, N., Wu, M., et al. HIV envelope glycoform heterogeneity and localized diversity govern the initiation and maturation of a V2 apex broadly neutralizing antibody lineage Immunity  2017 47:990-1003  DOI:10.1016/j.immuni.2017.11.002  PMID:29166592  PMCID:PMC5736302
    • Kulp, D. W., Steichen, J. M., Pauthner, M., Hu, X., Schiffner, T., Liguori, A., Cottrell, C. A., Havenar-Daughton, C., Ozorowski, G., Georgeson, E., Kalyuzhniy, O., Willis, J. R., et al. Structure-based design of native-like HIV-1 envelope trimers to silence non-neutralizing epitopes and eliminate CD4 binding Nature Communications  2017 8  DOI:10.1038/s41467-017-01549-6  PMID:29162799  PMCID:PMC5698488
    • Magnani, D. M., Silveira, C. G. T., Ricciardi, M. J., Gonzalez-Nieto, L., Pedreno-Lopez, N., Bailey, V. K., Gutman, M. J., Maxwell, H. S., Domingues, A., Costa, P. R., Ferrari, L., Goulart, R., et al. Potent plasmablast-derived antibodies elicited by the national institutes of health dengue vaccine Journal of Virology  2017 91:e00867-17  DOI:10.1128/jvi.00867-17  PMID:28878078  PMCID:PMC5660501
    • Burton, D. R. What are the most powerful immunogen design vaccine strategies? Reverse vaccinology 2.0 shows great promise Cold Spring Harbor Perspectives in Biology  2017 9  DOI:10.1101/cshperspect.a030262  PMID:28159875  PMCID:PMC5540812
    • Xu, L., Pegu, A., Rao, E., Doria-Rose, N., Beninga, J., McKee, K., Lord, D. M., Wei, R. R., Deng, G. J., Louder, M., Schmidt, S. D., Mankoff, Z., et al. Trispecific broadly neutralizing HIV antibodies mediate potent SHIV protection in macaques Science  2017 358:85-89  DOI:10.1126/science.aan8630  PMID:28931639
    • Magnani, D. M., Ricciardi, M. J., Bailey, V. K., Gutman, M. J., Pedreno-Lopez, N., Silveira, C. G. T., Maxwell, H. S., Domingues, A., Gonzalez-Nieto, L., Su, Q., Newman, R. M., Pack, M., et al. Dengue virus evades AAV-mediated neutralizing antibody prophylaxis in Rhesus monkeys Molecular Therapy  2017 25:2323-2331  DOI:10.1016/j.ymthe.2017.06.020  PMID:28750738  PMCID:PMC5628771
    • Magnani, D. M., Rogers, T. F., Beutler, N., Ricciardi, M. J., Bailey, V. K., Gonzalez-Nieto, L., Briney, B., Sok, D., Le, K., Strubel, A., Gutman, M. J., Pedreno-Lopez, N., et al. Neutralizing human monoclonal antibodies prevent Zika virus infection in macaques Science Translational Medicine  2017 9  DOI:10.1126/scitranslmed.aan8184  PMID:28978754
    • Voss, J. E., Andrabi, R., McCoy, L. E., de Val, N., Fuller, R. P., Messmer, T., Su, C. Y., Sok, D., Khan, S. N., Garces, F., Pritchard, L. K., Wyatt, R. T., et al. Elicitation of neutralizing antibodies targeting the V2 apex of the HIV Envelope trimer in a wild-type animal model Cell Reports  2017 21:222-235  DOI:10.1016/j.celrep.2017.09.024  PMID:28978475  PMCID:PMC5640805
    • Julg, B., Sok, D., Schmidt, S. D., Abbink, P., Newman, R. M., Broge, T., Linde, C., Nkolola, J., Le, K., Su, D., Torabi, J., Pack, M., et al. Protective efficacy of broadly neutralizing antibodies with incomplete neutralization activity against simian-human immunodeficiency virus in rhesus monkeys Journal of Virology  2017 91:e01187-17  DOI:10.1128/jvi.01187-17  PMID:28768869  PMCID:PMC5625479
    • Julg, B., Liu, P. T., Wagh, K., Fischer, W. M., Abbink, P., Mercado, N. B., Whitney, J. B., Nkolola, J. P., McMahan, K., Tartaglia, L. J., Borducchi, E. N., Khatiwada, S., et al. Protection against a mixed SHIV challenge by a broadly neutralizing antibody cocktail Science Translational Medicine  2017 9  DOI:10.1126/scitranslmed.aao4235  PMID:28931655
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    • Barbas, S. M., Ghazal, P., Barbas, C. F., Burton, D. R. Recognition of DNA by synthetic antibodies Journal of the American Chemical Society  1994 116:2161-2162  DOI:10.1021/ja00084a073
    • Crowe, J. E., Murphy, B. R., Chanock, R. M., Williamson, R. A., Barbas, C. F., Burton, D. R. Recombinant human respiratory syncytial virus (rsv) monoclonal-antibody fab is effective therapeutically when introduced directly into the lungs of rsv-infected mice Proceedings of the National Academy of Sciences of the United States of America  1994 91:1386-1390  DOI:10.1073/pnas.91.4.1386  PMID:8108420
    • Burioni, R., Williamson, R. A., Sanna, P. P., Bloom, F. E., Burton, D. R. Recombinant human fab to glycoprotein-d neutralizes infectivity and prevents cell-to-cell transmission of herpes-simplex virus-1 and virus-2 in-vitro Proceedings of the National Academy of Sciences of the United States of America  1994 91:355-359  DOI:10.1073/pnas.91.1.355  PMID:8278393
    • Hexham, J. M., Partridge, L. J., Furmaniak, J., Petersen, V. B., Colls, J. C., Pegg, C., Rees, S. B., Burton, D. R. Cloning and characterization of tpo autoantibodies using combinatorial phage display libraries Autoimmunity  1994 17:167-179  PMID:7524700
    • Pease, J. E., Burton, D. R., Barker, M. D. Generation of chimeric c5a/formyl peptide receptors - towards the identification of the human c5a receptor-binding site European Journal of Immunology  1994 24:211-215  DOI:10.1002/eji.1830240133  PMID:8020557
    • Burton, D. R., Barbas, C. F. Human-antibodies from combinatorial libraries Advances in Immunology  1994 57:191-280  DOI:10.1016/s0065-2776(08)60674-4  PMID:7872158
    • Prusiner, S. B., Groth, D., Serban, A., Koehler, R., Foster, D., Torchia, M., Burton, D., Yang, S. L., Dearmond, S. J. Ablation of the prion protein (prp) gene in mice prevents scrapie and facilitates production of anti-prp antibodies Proceedings of the National Academy of Sciences of the United States of America  1993 90:10608-10612  DOI:10.1073/pnas.90.22.10608  PMID:7902565
    • Sasano, M., Burton, D. R., Silverman, G. J. Molecular-selection of human-antibodies with an unconventional bacterial b-cell antigen Journal of Immunology  1993 151:5822-5839  PMID:8228264
    • Soultanas, P., Andrews, P. D., Burton, D. R., Hornby, D. P. Modulation of human DNA methyltransferase activity and messenger-rna levels in the monoblast cell-line u937 induced to differentiate with dibutyryl-cyclic-amp and phorbol ester Journal of Molecular Endocrinology  1993 11:191-200  PMID:8297475
    • Burton, D. R. Monoclonal antibodies from combinatorial libraries Accounts of Chemical Research  1993 26:405-411  DOI:10.1021/ar00032a003
    • Chanock, R. M., Crowe, J. E., Murphy, B. R., Burton, D. R. Human monoclonal-antibody fab fragments cloned from combinatorial libraries - potential usefulness in prevention and/or treatment of major human viral diseases Infectious Agents and Disease-Reviews Issues and Commentary  1993 2:118-131  PMID:8173784
    • Williamson, R. A., Burioni, R., Sanna, P. P., Partridge, L. J., Barbas, C. F., Burton, D. R. Human monoclonal-antibodies against a plethora of viral pathogens from single combinatorial libraries Proceedings of the National Academy of Sciences of the United States of America  1993 90:4141-4145  DOI:10.1073/pnas.90.9.4141  PMID:7683424
    • Barbas, C. F., Collet, T. A., Amberg, W., Roben, P., Binley, J. M., Hoekstra, D., Cababa, D., Jones, T. M., Williamson, R. A., Pilkington, G. R., Haigwood, N. L., Cabezas, E., et al. Molecular profile of an antibody-response to hiv-1 as probed by combinatorial libraries Journal of Molecular Biology  1993 230:812-823  DOI:10.1006/jmbi.1993.1203  PMID:8478936
    • Pease, J. E., Burton, D. R., Barker, M. D. The generation of stable cho-cell lines expressing very high-levels of complement c5a receptors and subsequent modulation of binding-affinity for c5a Biochemistry and Molecular Biology International  1993 29:339-347  PMID:8495216
    • Burton, D. R., Barbas, C. F. Human-antibodies to hiv-1 by recombinant-DNA methods Chemical Immunology  1993 56:112-126  PMID:8452652
    • Collet, T. A., Roben, P., Okennedy, R., Barbas, C. F., Burton, D. R., Lerner, R. A. A binary plasmid system for shuffling combinatorial antibody libraries Proceedings of the National Academy of Sciences of the United States of America  1992 89:10026-10030  DOI:10.1073/pnas.89.21.10026  PMID:1438192
    • Barbas, C. F., Crowe, J. E., Cababa, D., Jones, T. M., Zebedee, S. L., Murphy, B. R., Chanock, R. M., Burton, D. R. Human monoclonal fab fragments derived from a combinatorial library bind to respiratory syncytial virus-f glycoprotein and neutralize infectivity Proceedings of the National Academy of Sciences of the United States of America  1992 89:10164-10168  PMID:1279672  PMCID:PMC50298
    • Burton, D. R. Human monoclonal antibodies: achievement and potential Hospital Practice  1992 27:67-74
    • Zebedee, S. L., Barbas, C. F., Hom, Y. L., Caothien, R. H., Graff, R., Degraw, J., Pyati, J., Lapolla, R., Burton, D. R., Lerner, R. A., Thornton, G. B. Human combinatorial antibody libraries to hepatitis-b surface-antigen Proceedings of the National Academy of Sciences of the United States of America  1992 89:3175-3179  DOI:10.1073/pnas.89.8.3175  PMID:1373487
    • Duchosal, M. A., Eming, S. A., Fischer, P., Leturcq, D., Barbas, C. F., McConahey, P. J., Caothien, R. H., Thornton, G. B., Dixon, F. J., Burton, D. R. Immunization of hu-pbl-scid mice and the rescue of human monoclonal fab fragments through combinatorial libraries Nature  1992 355:258-262  DOI:10.1038/355258a0  PMID:1731222
    • Hexham, J. M., Furmaniak, J., Pegg, C., Burton, D. R., Smith, B. R. Cloning of a human autoimmune-response - preparation and sequencing of a human antithyroglobulin autoantibody using a combinatorial approach Autoimmunity  1992 12:135-141  DOI:10.3109/08916939209150320  PMID:1617110
    • Burton, D. R., Woof, J. M. Human antibody effector function Advances in Immunology  1992 51:1-84  DOI:10.1016/s0065-2776(08)60486-1  PMID:1502974
    • Barbas, C. F., Bjorling, E., Chiodi, F., Dunlop, N., Cababa, D., Jones, T. M., Zebedee, S. L., Persson, M. A. A., Nara, P. L., Norrby, E., Burton, D. R. Recombinant human fab fragments neutralize human type-1 immunodeficiency virus in vitro Proceedings of the National Academy of Sciences of the United States of America  1992 89:9339-9343  PMID:1384050  PMCID:PMC50122
    • Kang, A. S., Jones, T. M., Burton, D. R. Antibody redesign by chain shuffling from random combinatorial immunoglobulin libraries Proceedings of the National Academy of Sciences of the United States of America  1991 88:11120-11123  DOI:10.1073/pnas.88.24.11120  PMID:1763028
    • Burton, D. R., Barbas, C. F., Persson, M. A. A., Koenig, S., Chanock, R. M., Lerner, R. A. A large array of human monoclonal-antibodies to type-1 human-immunodeficiency-virus from combinatorial libraries of asymptomatic seropositive individuals Proceedings of the National Academy of Sciences of the United States of America  1991 88:10134-10137  DOI:10.1073/pnas.88.22.10134  PMID:1719545
    • Lerner, R. A., Barbas, C. F., Kang, A. S., Burton, D. R. On the use of combinatorial antibody libraries to clone the fossil record of an individuals immune-response Proceedings of the National Academy of Sciences of the United States of America  1991 88:9705-9706  DOI:10.1073/pnas.88.21.9705  PMID:1946391
    • Lund, J., Winter, G., Jones, P. T., Pound, J. D., Tanaka, T., Walker, M. R., Artymiuk, P. J., Arata, Y., Burton, D. R., Jefferis, R., Woof, J. M. Human fc-gamma-ri and fc-gamma-rii interact with distinct but overlapping sites on human-igg Journal of Immunology  1991 147:2657-2662  PMID:1833457
    • Williamson, R. A., Persson, M. A. A., Burton, D. R. Expression of a human monoclonal anti-(rhesus-d) fab fragment in escherichia-coli with the use of bacteriophage-lambda vectors Biochemical Journal  1991 277:561-563  PMID:1830475  PMCID:PMC1151271
    • Burton, D. R. Human and mouse monoclonal-antibodies by repertoire cloning Trends in Biotechnology  1991 9:169-175  DOI:10.1016/0167-7799(91)90055-m  PMID:1367284
    • Sheth, B., Banks, P., Burton, D. R., Monk, P. N. The regulation of actin polymerization in differentiating u937 cells correlates with increased membrane levels of the pertussis-toxin-sensitive g-protein gi2 Biochemical Journal  1991 275:809-811  PMID:1645523  PMCID:PMC1150128
    • Persson, M. A. A., Caothien, R. H., Burton, D. R. Generation of diverse high-affinity human monoclonal-antibodies by repertoire cloning Proceedings of the National Academy of Sciences of the United States of America  1991 88:2432-2436  DOI:10.1073/pnas.88.6.2432  PMID:1826052
    • Blackburn, G. M., Kingsbury, G., Jayaweera, S., Burton, D. R. Expanded transition-state analogs Ciba Foundation Symposia  1991 159:211-226  PMID:1959449
    • Davis, K. G., Glennie, M., Harding, S. E., Burton, D. R. A model for the solution conformation of rat ige Biochemical Society Transactions  1990 18:935-936  PMID:2083747
    • Burton, D. R. Antibody - the flexible adapter molecule Trends in Biochemical Sciences  1990 15:64-69  DOI:10.1016/0968-0004(90)90178-e  PMID:2186517
    • Kang, A. S., Kingsbury, G. A., Blackburn, G. M., Burton, D. R. Catalytic antibodies - designer enzymes Chemistry in Britain  1990 26:128-132
    • Huse, W. D., Sastry, L., Iverson, S. A., Kang, A. S., Altingmees, M., Burton, D. R., Benkovic, S. J., Lerner, R. A. Generation of a large combinatorial library of the immunoglobulin repertoire in phage-lambda Science  1989 246:1275-1281  DOI:10.1126/science.2531466  PMID:2531466
    • Blackburn, G. M., Kingsbury, G. A., Burton, D. R. Catalytic antibodies Biochemical Journal  1989 262:381-390  PMID:2679548  PMCID:PMC1133279
    • Burton, D., Artymiuk, P., Ford, G. Death by antibody New Scientist  1989 122:42-45
    • Walker, M. R., Woof, J. M., Bruggemann, M., Jefferis, R., Burton, D. R. Interaction of human-igg chimeric antibodies with the human fcri and fcrii receptors - requirements for antibody-mediated host-cell target-cell interaction Molecular Immunology  1989 26:403-411  DOI:10.1016/0161-5890(89)90129-6  PMID:2716734
    • Burton, D. R. Molecular-basis of antibody effector function Biochemical Society Transactions  1988 16:953-956  PMID:3224761
    • Burton, D. R., Jefferis, R., Partridge, L. J., Woof, J. M. Molecular recognition of antibody (igg) by cellular fc receptor (fcri) Molecular Immunology  1988 25:1175-1181  DOI:10.1016/0161-5890(88)90153-8  PMID:2975762
    • Woof, J. M., Burton, D. R. Microassay for measurement of binding of radiolabeled ligands to cell-surface molecules Journal of Immunological Methods  1988 111:205-207  DOI:10.1016/0022-1759(88)90128-7  PMID:2840465
    • Banks, P., Barker, M. D., Burton, D. R. Recruitment of actin to the cytoskeletons of human monocyte-like cells activated by complement fragment-c5a - is protein kinase-c involved Biochemical Journal  1988 252:765-769  PMID:3421921  PMCID:PMC1149213
    • Duncan, A. R., Woof, J. M., Partridge, L. J., Burton, D. R., Winter, G. Localization of the binding-site for the human high-affinity fc receptor on igg Nature  1988 332:563-564  DOI:10.1038/332563a0  PMID:2965792
    • Dransfield, I., Corcoran, D., Partridge, L. J., Hogg, N., Burton, D. R. Comparison of human-monocytes isolated by elutriation and adherence suggests that heterogeneity may reflect a continuum of maturation activation states Immunology  1988 63:491-498  PMID:3350583  PMCID:PMC1454750
    • Sheth, B., Dransfield, I., Partridge, L. J., Barker, M. D., Burton, D. R. Dibutyryl cyclic-amp stimulation of a monocyte-like cell-line, u937 - a model for monocyte chemotaxis and fc receptor-related functions Immunology  1988 63:483-490  PMID:2832314  PMCID:PMC1454775
    • Walker, M. R., Kumpel, B. M., Thompson, K., Woof, J. M., Burton, D. R., Jefferis, R. Immunogenic and antigenic epitopes of immunoglobulins binding of human monoclonal anti-d antibodies to fcri on the monocyte-like u937 cell-line Vox Sanguinis  1988 55:222-228  PMID:2464239
    • Gregory, L., Davis, K. G., Sheth, B., Boyd, J., Jefferis, R., Nave, C., Burton, D. R. The solution conformations of the subclasses of human-igg deduced from sedimentation and small-angle x-ray-scattering studies Molecular Immunology  1987 24:821-829  DOI:10.1016/0161-5890(87)90184-2  PMID:3657808
    • Partridge, L. J., Woof, J. M., Jefferis, R., Burton, D. R. The use of anti-igg monoclonal-antibodies in mapping the monocyte receptor-site on igg Molecular Immunology  1986 23:1365-1372  DOI:10.1016/0161-5890(86)90022-2  PMID:2434846
    • Burton, D. R. Is igm-like dislocation a common feature of antibody function Immunology Today  1986 7:165-167  DOI:10.1016/0167-5699(86)90166-0  PMID:25290200
    • Barker, M. D., Jose, P. J., Williams, T. J., Burton, D. R. The chemoattractant des-arg74-c5a regulates the expression of its own receptor on a monocyte-like cell-line Biochemical Journal  1986 236:621-624  PMID:3019322
    • Woof, J. M., Partridge, L. J., Jefferis, R., Burton, D. R. Localization of the monocyte-binding region on human immunoglobulin-g Molecular Immunology  1986 23:319-330  DOI:10.1016/0161-5890(86)90059-3  PMID:3487030
    • Burton, D. R., Gregory, L., Jefferis, R. Aspects of the molecular-structure of igg subclasses Monographs in Allergy  1986 19:7-35  PMID:2945094
    • Leatherbarrow, R. J., Rademacher, T. W., Dwek, R. A., Woof, J. M., Clark, A., Burton, D. R., Richardson, N., Feinstein, A. Effector functions of a monoclonal aglycosylated mouse igg2a - binding and activation of complement component c1 and interaction with human monocyte fc-receptor Molecular Immunology  1985 22:407-415  DOI:10.1016/0161-5890(85)90125-7  PMID:4033665
    • Burton, D. R. Immunoglobulin-g - functional sites Molecular Immunology  1985 22:161-206  DOI:10.1016/0161-5890(85)90151-8  PMID:3889592
    • Perkins, S. J., Villiers, C. L., Arlaud, G. J., Boyd, J., Burton, D. R., Colomb, M. G., Dwek, R. A. Neutron-scattering studies of subcomponent clq of 1st component cl of human-complement and its association with subunit clr2cls2 within cl Journal of Molecular Biology  1984 179:547-557  DOI:10.1016/0022-2836(84)90079-2  PMID:6096553
    • Woof, J. M., Jaafar, M. I. N., Jefferis, R., Burton, D. R. The monocyte binding domain(s) on human immunoglobulin-g Molecular Immunology  1984 21:523-527  DOI:10.1016/0161-5890(84)90068-3  PMID:6235444
    • Boyd, J., Burton, D. R., Perkins, S. J., Villiers, C. L., Dwek, R. A., Arlaud, G. J. Neutron-scattering studies of the isolated c1r2c1s2 subunit of 1st component of human-complement in solution Proceedings of the National Academy of Sciences of the United States of America  1983 80:3769-3773  DOI:10.1073/pnas.80.12.3769  PMID:6304736
    • Emanuel, E. J., Brampton, A. D., Burton, D. R., Dwek, R. A. Formation of complement subcomponent c1q immunoglobulin-g complex - thermodynamic and chemical-modification studies Biochemical Journal  1982 205:361-372  PMID:6982707  PMCID:PMC1158489
    • Isaksson-Forsen, G., Elgjo, K., Burton, D., Iversen, O. H. Partial purification of the epidermal G2 chalone based on an in vivo assay system Cell Biology International Reports  1981 5:195-199  DOI:10.1016/0309-1651(81)90028-x  PMID:6452953
    • Burton, D. R., Forsen, S., Reimarsson, P. The interaction of polyamines with DNA - a na-23 NMR-study Nucleic Acids Research  1981 9:1219-1228  DOI:10.1093/nar/9.5.1219  PMID:7232215
    • Burton, D. R., Boyd, J., Brampton, A. D., Easterbrooksmith, S. B., Emanuel, E. J., Novotny, J., Rademacher, T. W., Vanschravendijk, M. R., Sternberg, M. J. E., Dwek, R. A. The c1q receptor-site on immunoglobulin-g Nature  1980 288:338-344  DOI:10.1038/288338a0  PMID:6776418
    • Burton, D. R., Forsen, S., Karlstrom, G., Dwek, R. A. Proton relaxation enhancement (pre) in biochemistry - critical survey Progress in Nuclear Magnetic Resonance Spectroscopy  1979 13:1-45  DOI:10.1016/0079-6565(79)80012-6
    • Burton, D. R., Forsen, S., Franek, F., Novotny, J. Proton relaxation enhancement to probe the effects of antigen-binding on pig antibody structure FEBS Letters  1979 102:249-252  DOI:10.1016/0014-5793(79)80011-3  PMID:88375
    • Burton, D. R., Butler, M. J., Hyde, J. E., Phillips, D., Skidmore, C. J., Walker, I. O. Interaction of core histones with DNA - equilibrium binding studies Nucleic Acids Research  1978 5:3643-3663  DOI:10.1093/nar/5.10.3643  PMID:724497
    • Burton, D. R., Reimarsson, P. Na-23 NMR as a probe of ion binding to chromatin FEBS Letters  1978 89:183-186  DOI:10.1016/0014-5793(78)80213-0  PMID:658406
    • Korsgaard, R., Iversen, O. H., Isaksson-Forsen, G., Burton, D. R. Specificity of epidermal chalone extracts for human epidermoid tumour cells in vitro: a preliminary report Cell and Tissue Kinetics  1978 11:441-443  DOI:10.1111/j.1365-2184.1978.tb00816.x  PMID:150948
    • Burton, D. R., Forsen, S., Karlstrom, G., Dwek, R. A., McLaughlin, A. C., Wainhobson, S. Determination of molecular-motion parameters from proton-relaxation-enhancement measurements in a number of gd(iii) antibody-fragment complexes - comparative-study European Journal of Biochemistry  1977 75:445-453  DOI:10.1111/j.1432-1033.1977.tb11547.x  PMID:560299
    • Wright, C., Willan, K. J., Sjodahl, J., Burton, D. R., Dwek, R. A. Interaction of protein-a and fc-fragment of rabbit immunoglobulin-g as probed by complement-fixation and NMR-studies Biochemical Journal  1977 167:661-668  PMID:603628  PMCID:PMC1183712
    • Burton, D. R., Dwek, R. A., Forsen, S., Karlstrom, G. Novel-approach to water proton relaxation in paramagnetic ion macromolecule complexes Biochemistry  1977 16:250-254  DOI:10.1021/bi00621a014  PMID:836785
    • Isaksson-Forsen, G., Burton, D. R., Korsgaard, R., Elgjo, K., Iversen, O. H. Partial purification of epidermal G2 chalone Virchows Archiv B-Cell Pathology Including Molecular Pathology  1977 26:97-103  PMID:146951
    • Korsgaard, R., Iversen, O. H., Burton, D. R., Isaksson-Forsen, G. [Species-non-specific and reversible growth inhibition by chalones in human epidermoid carcinomas in vitro] Zeitschrift für Krebsforschung und Klinische Onkologie  1977 88:217-221  DOI:10.1007/bf00305359  PMID:140538
    • Burton, D. R., Forsen, S., Karlstrom, G., Dwek, R. A., McLaughlin, A. C., Wainhobson, S. Difficulties in determining accurate molecular-motion parameters from proton relaxation enhancement measurements as illustrated by immunoglobulin-g . Gd(iii) system European Journal of Biochemistry  1976 71:519-528  DOI:10.1111/j.1432-1033.1976.tb11140.x  PMID:188653
    • Burton, D. R., Hyde, J. E., Walker, I. O. Histones f2a1 and f3 interact reversibly and cooperatively with DNA to form an equimolar complex in chromatin FEBS Letters  1975 55:77-80  DOI:10.1016/0014-5793(75)80962-8  PMID:1170100
  • chapter

    • Calarese, D., Scanlan, C., Lee, H. K., Rudd, P., Dwek, R. Toward a carbohydrate-based HIV-1 vaccine ACS Symposium Series. 161-185. 2006  DOI:10.1021/bk-2006-0932.ch007

editor of

  • book

    • Barbas III, C., Burton, D., Scott, J. K., Silverman, G. J., eds. Phage display : a laboratory manual Cold Spring Harbor, NY: Cold Spring Harbor Laboratory Press. 2001

featured in

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  • Consortium Led by Scripps Research Institute Scientist Wins Up to $28 Million from NIH to Find Best Proposed Ebola Treatment  News Release
  • New Vaccine-Design Approach Targets HIV and Other Fast-Mutating Viruses  News Release
  • Preclinical Study Offers Hope for New Approach to Controlling HIV  News Release
  • Scientists Capture Most Detailed Picture Yet of Key AIDS Protein  News Release
  • Scientists Reveal Surprising Picture of How Powerful Antibody Neutralizes HIV  News Release
  • Scripps Research Institute Study Explores Barriers to HIV Vaccine Response  News Release
  • TSRI Named ‘Top Institution’ in HIV/AIDS Research; Dennis Burton, ‘Hot Researcher’  Newsletter
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Affiliation

head of

  • IAVI Neutralizing Antibody Center Director
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Research

research overview

  • Antibodies and Infectious Disease

    The perception of man as the easy victor over microbes has changed dramatically in the last two decades. Vaccination has offered protection against a number of viral pathogens, but it is increasingly recognized that the strategies used in the past will not be successful against all viruses. More understanding of viral pathogenesis and the interaction of viruses with the immune system is required. We are focused on the interplay of antibodies and viruses in humans, and it particular, the highly mutable viruses, human immunodeficiency virus type 1 (HIV-1) and hepatitis C virus (HCV). We have developed broadly neutralizing antibodies to these viruses to explore the anti-viral activity of antibodies in vitro and in vivo and to define molecular targets for rational vaccine design.

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Teaching

advisees

  • graduate advising relationship

    • Altman, Pilar , Ph.D.  candidate, 2018 -
    • Joyce, Collin Matthew, Ph.D.  candidate, 2018 -
    • Song, Ge, Ph.D.  candidate, 2017 -
    • Zhao, Fangzhu, Ph.D.  candidate, 2018 -
    • Pauthner, Matthias, Ph.D.  candidate, 2013 - 2017
    • Wold, Erik, Ph.D.  candidate, 2010 - 2015
    • Sok, Devin, Ph.D.  candidate, 2009 - 2014
    • Walker, Laura, Ph.D.  candidate, 2008 - 2011
    • Astronomo, Rena, Ph.D.  candidate, 2004 - 2009
    • Scherer, Erin, Ph.D.  candidate, 2004 - 2009
    • Bowley, Diana, Ph.D.  candidate, 2002 - 2007
    • Gakhal, Amandeep Dhillon , Ph.D.  candidate, 2003 - 2007
    • Barbas-Frederickson, Shana, Ph.D.  candidate, 1990 - 1995
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Background

education and training

  • Ph.D. in Physical Biochemistry, Lund University 1978
  • B.A. in Chemistry, University of Oxford , Oxon 1st Class 1974
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Contact

full name

  • Dennis R. Burton

geographic location

  • Scripps California 
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Identity

eRA Commons ID

  • Dennis_R_Burton

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