Burton, Dennis

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- Wec, A. Z., Wrapp, D., Herbert, A. S., Maurer, D. P., Haslwanter, D., Sakharkar, M., Jangra, R. K., Dieterle, M. E., Lilov, A., Huang, D. L., Tse, L. V., Johnson, N. V., et al. Broad neutralization of SARS-related viruses by human monoclonal antibodies Science 2020 369:731-736 DOI:10.1126/science.abc7424 PMID:32540900 PMCID:PMC7299279
- Carnathan, D. G., Kaushik, K., Ellebedy, A. H., Enemuo, C. A., Gebru, E. H., Dhadvai, P., Rasheed, M. A. U., Pauthner, M. G., Ozorowski, G., Ahmed, R., Burton, D. R., Ward, A. B., et al. Harnessing Activin A Adjuvanticity to Promote Antibody Responses to BG505 HIV Envelope Trimers Frontiers in Immunology 2020 11 DOI:10.3389/fimmu.2020.01213 PMID:32612608 PMCID:PMC7308430
- Nogal, B., McCoy, L. E., van Gils, M. J., Cottrell, C. A., Voss, J. E., Andrabi, R., Pauthner, M., Liang, C. H., Messmer, T., Nedellec, R., Shin, M., Turner, H. L., et al. HIV envelope trimer-elicited autologous neutralizing antibodies bind a region overlapping the N332 glycan supersite Science Advances 2020 6 DOI:10.1126/sciadv.aba0512 PMID:32548265 PMCID:PMC7274786
- Burton, D. R., Walker, L. M. Rational Vaccine Design in the Time of COVID-19 Cell Host & Microbe 2020 27:695-698 DOI:10.1016/j.chom.2020.04.022 PMID:32407707 PMCID:PMC7219357
- Yang, Y. H. R., McCoy, L. E., van Gils, M. J., Andrabi, R., Turner, H. L., Yuan, M., Cottrell, C. A., Ozorowski, G., Voss, J., Pauthner, M., Polveroni, T. M., Messmer, T., et al. Autologous antibody responses to an HIV envelope glycan hole are not easily broadened in rabbits Journal of Virology 2020 94 DOI:10.1128/jvi.01861-19 PMID:31941772 PMCID:PMC7081899
- Nogal, B., Bianchi, M., Cottrell, C. A., Kirchdoerfer, R. N., Sewall, L. M., Turner, H. L., Zhao, F., Sok, D., Burton, D. R., Hangartner, L., Ward, A. B. Mapping polyclonal antibody responses in non-human primates vaccinated with HIV env trimer subunit vaccines Cell Reports 2020 30:3755-3765 DOI:10.1016/j.celrep.2020.02.061 PMID:32187547 PMCID:PMC7153566
- Pedreno-Lopez, N., Dang, C. M., Rosen, B. C., Ricciardi, M. J., Bailey, V. K., Gutman, M. J., Gonzalez-Nieto, L., Pauthner, M. G., Le, K., Song, G., Andrabi, R., Weisgrau, K. L., et al. Induction of transient virus replication facilitates antigen-independent isolation of SIV-specific monoclonal antibodies Molecular Therapy-Methods & Clinical Development 2020 16:225-237 DOI:10.1016/j.omtm.2020.01.010 PMID:32083148 PMCID:PMC7021589
- Moyer, T. J., Kato, Y., Abraham, W., Chang, J. Y. H., Kulp, D. W., Watson, N., Turner, H. L., Menis, S., Abbott, R. K., Bhiman, J. N., Melo, M. B., Simon, H. A., et al. Engineered immunogen binding to alum adjuvant enhances humoral immunity Nature Medicine 2020 26:430-440 DOI:10.1038/s41591-020-0753-3 PMID:32066977 PMCID:PMC7069805
- Pedreno-Lopez, N., Ricciardi, M. J., Rosen, B. C., Song, G., Andrabi, R., Burton, D. R., Rakasz, E. G., Watkins, D. I. An Automated Fluorescence-Based Method to Isolate Bone Marrow-Derived Plasma Cells from Rhesus Macaques Using SIVmac239 SOSIP.664 Molecular Therapy-Methods & Clinical Development 2020 18:781-790 DOI:10.1016/j.omtm.2020.08.004 PMID:32953929 PMCID:PMC7476808
- Joyce, C., Burton, D. R., Briney, B. Comparisons of the antibody repertoires of a humanized rodent and humans by high throughput sequencing Scientific Reports 2020 10 DOI:10.1038/s41598-020-57764-7 PMID:31980672 PMCID:PMC6981180
- Rogers, T. F., Zhao, F., Huang, D. L., Beutler, N., Burns, A., He, W. T., Limbo, O., Smith, C., Song, G., Woehl, J., Yang, L. L., Abbott, R. K., et al. Isolation of potent SARS-CoV-2 neutralizing antibodies and protection from disease in a small animal model Science 2020 369:956-963 DOI:10.1126/science.abc7520 PMID:32540903 PMCID:PMC7299280
- Zhao, F., Joyce, C., Burns, A., Nogal, B., Cottrell, C. A., Ramos, A., Biddle, T., Pauthner, M., Nedellec, R., Qureshi, H., Mason, R., Landais, E., et al. Mapping Neutralizing Antibody Epitope Specificities to an HIV Env Trimer in Immunized and in Infected Rhesus Macaques Cell Reports 2020 32 DOI:10.1016/j.celrep.2020.108122 PMID:32905766 PMCID:PMC7487785
- Cottrell, C. A., van Schooten, J., Bowman, C. A., Yuan, M., Oyen, D., Shin, M., Morpurgo, R., van der Woude, P., van Breemen, M., Torres, J. L., Patel, R., Gross, J., et al. Mapping the immunogenic landscape of near-native HIV-1 envelope trimers in non-human primates PLoS Pathogens 2020 16 DOI:10.1371/journal.ppat.1008753 PMID:32866207 PMCID:PMC7485981
- Yuan, M., Liu, H. J., Wu, N. C., Lee, C. C. D., Zhu, X. Y., Zhao, F., Huang, D. L., Yu, W. L., Hua, Y. Z., Tien, H., Rogers, T. F., Landais, E., et al. Structural basis of a shared antibody response to SARS-CoV-2 Science 2020 369:1119-1123 DOI:10.1126/science.abd2321 PMID:32661058 PMCID:PMC7402627
- Steichen, J. M., Lin, Y. C., Havenar-Daughton, C., Pecetta, S., Ozorowski, G., Willis, J. R., Toy, L., Sok, D., Liguori, A., Kratochvil, S., Torres, J. L., Kalyuzhniy, O., et al. A generalized HIV vaccine design strategy for priming of broadly neutralizing antibody responses Science 2019 366 DOI:10.1126/science.aax4380 PMID:31672916
- Zhang, L., Irimia, A., He, L., Landais, E., Rantalainen, K., Leaman, D. P., Vollbrecht, T., Stano, A., Sands, D. I., Kim, A. S., Poignard, P., Burton, D. R., et al. An MPER antibody neutralizes HIV-1 using germline features shared among donors Nature Communications 2019 10 DOI:10.1038/s41467-019-12973-1 PMID:31772165 PMCID:PMC6879610
- Havenar-Daughton, C., Carnathan, D. G., Boopathy, A. V., Upadhyay, A. A., Murrell, B., Reiss, S. M., Enemuo, C. A., Gebru, E. H., Choe, Y., Dhadvai, P., Viviano, F., Kaushik, K., et al. Rapid germinal center and antibody responses in non-human primates after a single nanoparticle vaccine immunization Cell Reports 2019 29:1756-+ DOI:10.1016/j.celrep.2019.10.008 PMID:31722194
- Haynes, B. F., Burton, D. R., Mascola, J. R. Multiple roles for HIV broadly neutralizing antibodies Science Translational Medicine 2019 11 DOI:10.1126/scitranslmed.aaz2686 PMID:31666399
- Burton, D. R. Antibody barriers to going viral Journal of Experimental Medicine 2019 216:2226-2228 DOI:10.1084/jem.20191099 PMID:31444247 PMCID:PMC6781000
- Pegu, A., Borate, B., Huang, Y., Pauthner, M. G., Hessell, A. J., Julg, B., Doria-Rose, N. A., Schmidt, S. D., Carpp, L. N., Cully, M. D., Chen, X., Shaw, G. M., et al. A meta-analysis of passive immunization studies shows that serum-neutralizing antibody titer associates with protection against SHIV challenge Cell Host & Microbe 2019 26:336-346 DOI:10.1016/j.chom.2019.08.014 PMID:31513771 PMCID:PMC6755677
- Umotoy, J., Bagaya, B. S., Joyce, C., Schiffner, T., Menis, S., Saye-Francisco, K. L., Biddle, T., Mohan, S., Vollbrecht, T., Kalyuzhniy, O., Madzorera, S., Kitchin, D., et al. Rapid and Focused Maturation of a VRC01-Class HIV Broadly Neutralizing Antibody Lineage Involves Both Binding and Accommodation of the N276-Glycan Immunity 2019 51:141-154 DOI:10.1016/j.immuni.2019.06.004 PMID:31315032 PMCID:PMC6642152
- von Bredow, B., Andrabi, R., Grunst, M., Grandea, A. G., Le, K., Song, G., Berndsen, Z. T., Porter, K., Pallesen, J., Ward, A. B., Burton, D. R., Evans, D. T. Differences in the binding affinity of an HIV-1 V2 apex-specific antibody for the SIVsmm/mac envelope glycoprotein uncouple antibody-dependent cellular cytotoxicity from neutralization Mbio 2019 10:e01255-19 DOI:10.1128/mBio.01255-19 PMID:31266872 PMCID:PMC6606807
- Seabright, G. E., Doores, K. J., Burton, D. R., Crispin, M. Protein and glycan mimicry in HIV vaccine design Journal of Molecular Biology 2019 431:2223-2247 DOI:10.1016/j.jmb.2019.04.016 PMID:31028779 PMCID:PMC6556556
- Andrabi, R., Pallesen, J., Allen, J. D., Song, G., Zhang, J., de Val, N., Gegg, G., Porter, K., Su, C., Pauthner, M., Newman, A., Bouton-Verville, H., et al. The chimpanzee SIV envelope trimer: structure and deployment as an HIV vaccine template Cell Reports 2019 27:2426-2441 DOI:10.1016/j.celrep.2019.04.082 PMID:31116986 PMCID:PMC6533203
- Cirelli, K. M., Carnathan, D. G., Nogal, B., Martin, J. T., Rodriguez, O. L., Upadhyay, A. A., Enemuo, C. A., Gebru, E. H., Choe, Y., Viviano, F., Nakao, C., Pauthner, M. G., et al. Slow delivery immunization enhances HIV neutralizing antibody and germinal center responses via modulation of immunodominance Cell 2019 177:1153-1171 DOI:10.1016/j.cell.2019.04.012 PMID:31080066
- Briney, B., Inderbitzin, A., Joyce, C., Burton, D. R. Commonality despite exceptional diversity in the baseline human antibody repertoire Nature 2019 566:393-397 DOI:10.1038/s41586-019-0879-y PMID:30664748
- Burton, D. R. Advancing an HIV vaccine; advancing vaccinology Nature Reviews Immunology 2019 19:77-78 DOI:10.1038/s41577-018-0103-6 PMID:30560910
- Voss, J. E., Gonzalez-Martin, A., Andrabi, R., Fuller, R. P., Murrell, B., McCoy, L. E., Porter, K., Huang, D., Li, W., Sok, D., Le, K., Briney, B., et al. Reprogramming the antigen specificity of B cells using genome-editing technologies Elife 2019 8 DOI:10.7554/eLife.42995 PMID:30648968 PMCID:PMC6355199
- Pauthner, M. G., Nkolola, J. P., Havenar-Daughton, C., Murrell, B., Reiss, S. M., Bastidas, R., Prevost, J., Nedellec, R., von Bredow, B., Abbink, P., Cottrell, C. A., Kulp, D. W., et al. Vaccine-induced protection from homologous tier 2 SHIV challenge in nonhuman primates depends on serum-neutralizing antibody titers Immunity 2019 50:241-252 DOI:10.1016/j.immuni.2018.11.011 PMID:30552025 PMCID:PMC6335502
- Allen, E. R., Krumm, S. A., Raghwani, J., Halldorsson, S., Elliott, A., Graham, V. A., Koudriakova, E., Harlos, K., Wright, D., Warimwe, G. M., Brennan, B., Huiskonen, J. T., et al. A protective monoclonal antibody targets a site of vulnerability on the surface of Rift Valley fever virus Cell Reports 2018 25:3750-3758 DOI:10.1016/j.celrep.2018.12.001 PMID:30590046 PMCID:PMC6315105
- He, L., Kumar, S., Allen, J. D., Huang, D. L., Lin, X., Mann, C. J., Saye-Francisco, K. L., Copps, J., Sarkar, A., Blizard, G. S., Ozorowski, G., Sok, D., et al. HIV-1 vaccine design through minimizing envelope metastability Science Advances 2018 4 DOI:10.1126/sciadv.aau6769 PMID:30474059 PMCID:PMC6248932
- Sok, D., Burton, D. R. Recent progress in broadly neutralizing antibodies to HIV Nature Immunology 2018 19:1179-1188 DOI:10.1038/s41590-018-0235-7 PMID:30333615
- Cao, L. W., Pauthner, M., Andrabi, R., Rantalainen, K., Berndsen, Z., Diedrich, J. K., Menis, S., Sok, D., Bastidas, R., Park, S. K. R., Delahunty, C. M., He, L., et al. Differential processing of HIV envelope glycans on the virus and soluble recombinant trimer Nature Communications 2018 9 DOI:10.1038/s41467-018-06121-4 PMID:30209313 PMCID:PMC6135743
- Khan, S. N., Sok, D., Tran, K., Movsesyan, A., Dubrovskaya, V., Burton, D. R., Wyatt, R. T. Targeting the HIV-1 spike and coreceptor with bi- and trispecific antibodies for single-component broad inhibition of entry Journal of Virology 2018 92:e00384-18 DOI:10.1128/jvi.00384-18 PMID:29976677
- Bianchi, M., Turner, H. L., Nogal, B., Cottrell, C. A., Oyen, D., Pauthner, M., Bastidas, R., Nedellec, R., McCoy, L. E., Wilson, I. A., Burton, D. R., Ward, A. B., et al. Electron-microscopy-based epitope mapping defines specificities of polyclonal antibodies elicited during HIV-1 BG505 envelope trimer immunization Immunity 2018 49:288-300 DOI:10.1016/j.immuni.2018.07.009 PMID:30097292 PMCID:PMC6104742
- Saphire, E. O., Schendel, S. L., Fusco, M. L., Gangavarapu, K., Gunn, B. M., Wec, A. Z., Halfmann, P. J., Brannan, J. M., Herbert, A. S., Qiu, X. G., Wagh, K., He, S., et al. Systematic analysis of monoclonal antibodies against Ebola virus GP defines features that contribute to protection Cell 2018 174:938-952 DOI:10.1016/j.cell.2018.07.033 PMID:30096313 PMCID:PMC6102396
- Martins, M. A., Tully, D. C., Pedreno-Lopez, N., von Bredow, B., Pauthner, M. G., Shin, Y. C., Yuan, M. L., Lima, N. S., Bean, D. J., Gonzalez-Nieto, L., Domingues, A., Gutman, M. J., et al. Mamu-B*17(+) rhesus macaques vaccinated with env, vif, and nef manifest early control of SIVmac239 replication Journal of Virology 2018 92:e00690-18 DOI:10.1128/jvi.00690-18 PMID:29875239 PMCID:PMC6069176
- Andrabi, R., Bhiman, J. N., Burton, D. R. Strategies for a multi-stage neutralizing antibody-based HIV vaccine Current Opinion in Immunology 2018 53:143-151 DOI:10.1016/j.coi.2018.04.025 PMID:29775847 PMCID:PMC6141341
- Cao, L., Diedrich, J. K., Ma, Y., Wang, N., Pauthner, M., Park, S. K. R., Delahunty, C. M., McLellan, J. S., Burton, D. R., Yates III, J. R., Paulson, J. C. Global site-specific analysis of glycoprotein N-glycan processing Nature Protocols 2018 13:1196-1212 DOI:10.1038/nprot.2018.024 PMID:29725121 PMCID:PMC5941933
- Walker, L. M., Burton, D. R. Passive immunotherapy of viral infections: 'super-antibodies' enter the fray Nature Reviews Immunology 2018 18:297-308 DOI:10.1038/nri.2017.148 PMID:29379211 PMCID:PMC5918154
- Magnani, D. M., Rogers, T. F., Maness, N. J., Grubaugh, N. D., Beutler, N., Bailey, V. K., Gonzalez-Nieto, L., Gutman, M. J., Pedreno-Lopez, N., Kwal, J. M., Ricciardi, M. J., Myers, T. A., et al. Fetal demise and failed antibody therapy during Zika virus infection of pregnant macaques Nature Communications 2018 9 DOI:10.1038/s41467-018-04056-4 PMID:29691387 PMCID:PMC5915455
- Shivatare, V. S., Shivatare, S. S., Lee, C. C. D., Liang, C. H., Liao, K. S., Cheng, Y. Y., Saidachary, G., Wu, C. Y., Lin, N. H., Kwong, P. D., Burton, D. R., Wu, C. Y., et al. Unprecedented role of hybrid N-glycans as ligands for HIV-1 broadly neutralizing antibodies Journal of the American Chemical Society 2018 140:5202-5210 DOI:10.1021/jacs.8b00896 PMID:29578688
- Zhou, T., Zheng, A., Baxa, U., Chuang, G. Y., Georgiev, I. S., Kong, R., O'Dell, S., Shahzad-Ul-Hussan, S., Shen, C. H., Tsybovsky, Y., Bailer, R. T., Gift, S. K., et al. A neutralizing antibody recognizing primarily N-linked glycan targets the silent face of the HIV envelope Immunity 2018 48:500-513 DOI:10.1016/j.immuni.2018.02.013 PMID:29548671
- Wagh, K., Seaman, M. S., Zingg, M., Fitzsimons, T., Barouch, D. H., Burton, D. R., Connore, M., Ho, D. D., Mascola, J. R., Nussenzweig, M. C., Ravetch, J., Gautam, R., et al. Potential of conventional & bispecific broadly neutralizing antibodies for prevention of HIV-1 subtype A, C & D infections PLoS Pathogens 2018 14 DOI:10.1371/journal.ppat.1006860 PMID:29505593 PMCID:PMC5854441
- Teijaro, J. R., Burton, D. R. Taking down defenses to improve vaccines Science 2018 359:277-278 DOI:10.1126/science.aar5421 PMID:29348225
- Landais, E., Murrell, B., Briney, B., Murrell, S., Rantalainen, K., Berndsen, Z. T., Ramos, A., Wickramasinghe, L., Smith, M. L., Eren, K., de Val, N., Wu, M., et al. HIV envelope glycoform heterogeneity and localized diversity govern the initiation and maturation of a V2 apex broadly neutralizing antibody lineage Immunity 2017 47:990-1003 DOI:10.1016/j.immuni.2017.11.002 PMID:29166592 PMCID:PMC5736302
- Kulp, D. W., Steichen, J. M., Pauthner, M., Hu, X., Schiffner, T., Liguori, A., Cottrell, C. A., Havenar-Daughton, C., Ozorowski, G., Georgeson, E., Kalyuzhniy, O., Willis, J. R., et al. Structure-based design of native-like HIV-1 envelope trimers to silence non-neutralizing epitopes and eliminate CD4 binding Nature Communications 2017 8 DOI:10.1038/s41467-017-01549-6 PMID:29162799 PMCID:PMC5698488
- Magnani, D. M., Silveira, C. G. T., Ricciardi, M. J., Gonzalez-Nieto, L., Pedreno-Lopez, N., Bailey, V. K., Gutman, M. J., Maxwell, H. S., Domingues, A., Costa, P. R., Ferrari, L., Goulart, R., et al. Potent plasmablast-derived antibodies elicited by the national institutes of health dengue vaccine Journal of Virology 2017 91:e00867-17 DOI:10.1128/jvi.00867-17 PMID:28878078 PMCID:PMC5660501
- Burton, D. R. What are the most powerful immunogen design vaccine strategies? Reverse vaccinology 2.0 shows great promise Cold Spring Harbor Perspectives in Biology 2017 9 DOI:10.1101/cshperspect.a030262 PMID:28159875 PMCID:PMC5540812
- Xu, L., Pegu, A., Rao, E., Doria-Rose, N., Beninga, J., McKee, K., Lord, D. M., Wei, R. R., Deng, G. J., Louder, M., Schmidt, S. D., Mankoff, Z., et al. Trispecific broadly neutralizing HIV antibodies mediate potent SHIV protection in macaques Science 2017 358:85-89 DOI:10.1126/science.aan8630 PMID:28931639
- Magnani, D. M., Ricciardi, M. J., Bailey, V. K., Gutman, M. J., Pedreno-Lopez, N., Silveira, C. G. T., Maxwell, H. S., Domingues, A., Gonzalez-Nieto, L., Su, Q., Newman, R. M., Pack, M., et al. Dengue virus evades AAV-mediated neutralizing antibody prophylaxis in Rhesus monkeys Molecular Therapy 2017 25:2323-2331 DOI:10.1016/j.ymthe.2017.06.020 PMID:28750738 PMCID:PMC5628771
- Magnani, D. M., Rogers, T. F., Beutler, N., Ricciardi, M. J., Bailey, V. K., Gonzalez-Nieto, L., Briney, B., Sok, D., Le, K., Strubel, A., Gutman, M. J., Pedreno-Lopez, N., et al. Neutralizing human monoclonal antibodies prevent Zika virus infection in macaques Science Translational Medicine 2017 9 DOI:10.1126/scitranslmed.aan8184 PMID:28978754
- Voss, J. E., Andrabi, R., McCoy, L. E., de Val, N., Fuller, R. P., Messmer, T., Su, C. Y., Sok, D., Khan, S. N., Garces, F., Pritchard, L. K., Wyatt, R. T., et al. Elicitation of neutralizing antibodies targeting the V2 apex of the HIV Envelope trimer in a wild-type animal model Cell Reports 2017 21:222-235 DOI:10.1016/j.celrep.2017.09.024 PMID:28978475 PMCID:PMC5640805
- Julg, B., Sok, D., Schmidt, S. D., Abbink, P., Newman, R. M., Broge, T., Linde, C., Nkolola, J., Le, K., Su, D., Torabi, J., Pack, M., et al. Protective efficacy of broadly neutralizing antibodies with incomplete neutralization activity against simian-human immunodeficiency virus in rhesus monkeys Journal of Virology 2017 91:e01187-17 DOI:10.1128/jvi.01187-17 PMID:28768869 PMCID:PMC5625479
- Julg, B., Liu, P. T., Wagh, K., Fischer, W. M., Abbink, P., Mercado, N. B., Whitney, J. B., Nkolola, J. P., McMahan, K., Tartaglia, L. J., Borducchi, E. N., Khatiwada, S., et al. Protection against a mixed SHIV challenge by a broadly neutralizing antibody cocktail Science Translational Medicine 2017 9 DOI:10.1126/scitranslmed.aao4235 PMID:28931655
- Julg, B., Tartaglia, L. J., Keele, B. F., Wagh, K., Pegu, A., Sok, D., Abbink, P., Schmidt, S. D., Wang, K., Chen, X., Joyce, M. G., Georgiev, I. S., et al. Broadly neutralizing antibodies targeting the HIV-1 envelope V2 apex confer protection against a clade C SHIV challenge Science Translational Medicine 2017 9 DOI:10.1126/scitranslmed.aal1321 PMID:28878010
- He, L., Lin, X., de Val, N., Saye-Francisco, K. L., Mann, C. J., Augst, R., Morris, C. D., Azadnia, P., Zhou, B., Sok, D., Ozorowski, G., Ward, A. B., et al. Hidden lineage complexity of glycan-dependent HIV-1 broadly neutralizing antibodies uncovered by digital panning and native-like gp140 trimer Frontiers in Immunology 2017 8 DOI:10.3389/fimmu.2017.01025
- Sok, D., Le, K. M., Vadnais, M. L., Saye-Francisco, K. L., Jardine, J. G., Torres, J. L., Berndsen, Z. T., Kong, L., Tanfield, R. S., Ruiz, J., Ramos, A., Liang, C. H., et al. Rapid elicitation of broadly neutralizing antibodies to HIV by immunization in cows Nature 2017 548:108-111 DOI:10.1038/nature23301 PMID:28726771
- Rogers, T. F., Goodwin, E. C., Briney, B., Sok, D., Beutler, N., Strubel, A., Nedellec, R., Le, K., Brown, M. E., Burton, D. R., Walker, L. M. Zika virus activates de novo and cross-reactive memory B cell responses in dengue-experienced donors Science Immunology 2017 2 DOI:10.1126/sciimmunol.aan6809 PMID:28821561 PMCID:PMC5892203
- Martins, M. A., Shin, Y. C., Gonzalez-Nieto, L., Domingues, A., Gutman, M. J., Maxwell, H. S., Castro, I., Magnani, D. M., Ricciardi, M., Pedreno-Lopez, N., Bailey, V., Betancourt, D., et al. Vaccine-induced immune responses against both Gag and Env improve control of simian immunodeficiency virus replication in rectally challenged rhesus macaques PLoS Pathogens 2017 13 DOI:10.1371/journal.ppat.1006529 PMID:28732035 PMCID:PMC5540612
- Pauthner, M., Havenar-Daughton, C., Sok, D., Nkolola, J. P., Bastidas, R., Boopathy, A. V., Carnathan, D. G., Chandrashekar, A., Cirelli, K. M., Cottrell, C. A., Eroshkin, A. M., Guenaga, J., et al. Elicitation of robust tier 2 neutralizing antibody responses in nonhuman primates by HIV envelope trimer immunization using optimized approaches Immunity 2017 46:1073-1088 DOI:10.1016/j.immuni.2017.05.007 PMID:28636956 PMCID:PMC5483234
- Xie, J., Sok, D., Wu, N. C., Zheng, T., Zhang, W., Burton, D. R., Lerner, R. A. Immunochemical engineering of cell surfaces to generate virus resistance Proceedings of the National Academy of Sciences of the United States of America 2017 114:4655-4660 DOI:10.1073/pnas.1702764114 PMID:28396429 PMCID:PMC5422804
- Lee, J. H., Andrabi, R., Su, C. Y., Yasmeen, A., Julien, J. P., Kong, L., Wu, N. C., McBride, R., Sok, D., Pauthner, M., Cottrell, C. A., Nieusma, T., et al. A broadly neutralizing antibody targets the dynamic HIV envelope trimer apex via a long, rigidified, and anionic β-hairpin structure Immunity 2017 46:690-702 DOI:10.1016/j.immuni.2017.03.017 PMID:28423342 PMCID:PMC5400778
- Cao, L., Diedrich, J. K., Kulp, D. W., Pauthner, M., He, L., Park, S. K. R., Sok, D., Su, C. Y., Delahunty, C. M., Menis, S., Andrabi, R., Guenaga, J., et al. Global site-specific N-glycosylation analysis of HIV envelope glycoprotein Nature Communications 2017 8 DOI:10.1038/ncomms14954 PMID:28348411
- Haynes, B. F., Burton, D. R. HIV Developing an HIV vaccine Science 2017 355:1129-1130 DOI:10.1126/science.aan0662 PMID:28302812
- Irimia, A., Serra, A. M., Sarkar, A., Jacak, R., Kalyuzhniy, O., Sok, D., Saye-Francisco, K. L., Schiffner, T., Tingle, R., Kubitz, M., Adachi, Y., Stanfield, R. L., et al. Lipid interactions and angle of approach to the HIV-1 viral membrane of broadly neutralizing antibody 10E8: Insights for vaccine and therapeutic design PLoS Pathogens 2017 13 DOI:10.1371/journal.ppat.1006212 PMID:28225819 PMCID:PMC5338832
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- Burton, D. R. Shots in the dark: The wayward search for an aids vaccine Nature 2001 414:251-252 DOI:10.1038/35104670
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- Parren, Pwhi, Marx, P. A., Hessell, A. J., Luckay, A., Harouse, J., Cheng-Mayer, C., Moore, J. P., Burton, D. R. Antibody protects macaques against vaginal challenge with a pathogenic r5 simian/human immunodeficiency virus at serum levels giving complete neutralization in vitro Journal of Virology 2001 75:8340-8347 DOI:10.1128/jvi.75.17.8340-8347.2001 PMID:11483779
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- Bugli, F., Bastidas, R., Burton, D. R., Williamson, R. A., Clementi, M., Burioni, R. Molecular profile of a human monoclonal antibody fab fragment specific for epstein-barr virus gp350/220 antigen Human Immunology 2001 62:362-367 DOI:10.1016/s0198-8859(01)00216-6 PMID:11295468
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- Williamson, R. A., Burgoon, M. P., Owens, G. P., Ghausi, O., Leclerc, E., Firme, L., Carlson, S., Corboy, J., Parren, Pwhi, Sanna, P. P., Gilden, D. H., Burton, D. R. Anti-DNA antibodies are a major component of the intrathecal B cell response in multiple sclerosis Proceedings of the National Academy of Sciences of the United States of America 2001 98:1793-1798 DOI:10.1073/pnas.031567598 PMID:11172030 PMCID:PMC29336
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- Gilden, D. H., Burgoon, M. P., Kleinschmidt-DeMasters, B. K., Williamson, R. A., Ghausi, O., Burton, D. R., Owens, G. P. Molecular immunologic strategies to identify antigens and b-cell responses unique to multiple sclerosis Archives of Neurology 2001 58:43-48 DOI:10.1001/archneur.58.1.43 PMID:11176935
- Parren, Pwhi, Burton, D. R. The antiviral activity of antibodies in vitro and in vivo Advances in Immunology 2001 77:195-262 DOI:10.1016/s0065-2776(01)77018-6 PMID:11293117
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- Ditzel, H. J., Masaki, Y., Nielsen, H., Farnaes, L., Burton, D. R. Cloning and expression of a novel human antibody-antigen pair associated with felty's syndrome Proceedings of the National Academy of Sciences of the United States of America 2000 97:9234-9239 DOI:10.1073/pnas.97.16.9234 PMID:10922075
- Dorrell, L., Hessell, A. J., Wang, M., Whittle, H., Sabally, S., Rowland-Jones, S., Burton, D. R., Parren, Pwhi Absence of specific mucosal antibody responses in hiv-exposed uninfected sex workers from the gambia AIDS 2000 14:1117-1122 DOI:10.1097/00002030-200006160-00008 PMID:10894275
- Burton, D. R., Williamson, R. A., Parren, Pwhi Antibody and virus: Binding and neutralization Virology 2000 270:1-3 DOI:10.1006/viro.2000.0239 PMID:10772973
- Owens, G. P., Williamson, R. A., Burgoon, M. P., Ghausi, O., Burton, D. R., Gilden, D. H. Cloning the antibody response in humans with chronic inflammatory disease: Immunopanning of subacute sclerosing panencephalitis (sspe) brain sections with antibody phage libraries prepared from sspe brain enriches for antibody recognizing measles virus antigens in situ Journal of Virology 2000 74:1533-1537 DOI:10.1128/jvi.74.3.1533-1537.2000 PMID:10627565
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- Kanyo, Z. F., Pan, K. M., Williamson, R. A., Burton, D. R., Prusiner, S. B., Fletterick, R. J., Cohen, F. E. Antibody binding defines a structure for an epitope that participates in the prpc -> prpsc conformational change Journal of Molecular Biology 1999 293:855-863 DOI:10.1006/jmbi.1999.3193 PMID:10543972
- Maruyama, T., Rodriguez, L. L., Jahrling, P. B., Sanchez, A., Khan, A. S., Nichol, S. T., Peters, C. J., Parren, Pwhi, Burton, D. R. Ebola virus can be effectively neutralized by antibody produced in natural human infection Journal of Virology 1999 73:6024-6030 PMID:10364354 PMCID:PMC112663
- Sakurai, H., Williamson, R. A., Crowe, J. E., Beeler, J. A., Poignard, P., Bastidas, R. B., Chanock, R. M., Burton, D. R. Human antibody responses to mature and immature forms of viral envelope in respiratory syncytial virus infection: Significance for subunit vaccines Journal of Virology 1999 73:2956-2962 PMID:10074145 PMCID:PMC104055
- Sanna, P. P., Samson, M. E., Moon, J. S., Rozenshteyn, R., De Logu, A., Williamson, R. A., Burton, D. R. pFab-CMV, a single vector system for the rapid conversion of recombinant Fabs into whole IgG1 antibodies Immunotechnology 1999 4:185-188 DOI:10.1016/s1380-2933(98)00022-0 PMID:10231088
- Burgoon, M. P., Williamson, R. A., Owens, G. P., Ghausi, O., Bastidas, R. B., Burton, D. R., Gilden, D. H. Cloning the antibody response in humans with inflammatory cns disease: Isolation of measles virus-specific antibodies from phage display libraries of a subacute sclerosing panencephalitis brain Journal of Neuroimmunology 1999 94:204-211 DOI:10.1016/s0165-5728(98)00243-4 PMID:10376954
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- Frankel, S. S., Steinman, R. M., Michael, N. L., Kim, S. R., Bhardwaj, N., Pope, M., Louder, M. K., Ehrenberg, P. K., Parren, Pwhi, Burton, D. R., Katinger, H., VanCott, T. C., et al. Neutralizing monoclonal antibodies block human immunodeficiency virus type 1 infection of dendritic cells and transmission to t cells Journal of Virology 1998 72:9788-9794 PMID:9811714 PMCID:PMC110490
- De Logu, A., Williamson, R. A., Rozenshteyn, R., Ramiro-Ibanez, F., Simpson, C. D., Burton, D. R., Sanna, P. P. Characterization of a type-common human recombinant monoclonal antibody to herpes simplex virus with high therapeutic potential Journal of Clinical Microbiology 1998 36:3198-3204 PMID:9774565 PMCID:PMC105301
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- Parren, Pwhi, Mondor, I., Naniche, D., Ditzel, H. J., Klasse, P. J., Burton, D. R., Sattentau, Q. J. Neutralization of human immunodeficiency virus type 1 by antibody to gp120 is determined primarily by occupancy of sites on the virion irrespective of epitope specificity Journal of Virology 1998 72:3512-3519 PMID:9557629 PMCID:PMC109569
- LeBlanc, J. F., McLane, K. E., Parren, Pwhi, Burton, D. R., Ghazal, P. Recognition properties of a sequence-specific DNA binding antibody Biochemistry 1998 37:6015-6022 DOI:10.1021/bi9730792 PMID:9558339
- Ditzel, H. J., Rosenkilde, M. M., Garred, P., Wang, M., Koefoed, K., Pedersen, C., Burton, D. R., Schwartz, T. W. The ccr5 receptor acts as an alloantigen in ccr5 delta 32 homozygous individuals: Identification of chemokine- and hiv-1-blocking human antibodies Proceedings of the National Academy of Sciences of the United States of America 1998 95:5241-5245 DOI:10.1073/pnas.95.9.5241 PMID:9560260
- Salonen, E. M., Parren, Pwhi, Graus, Y. F., Lundkvist, A., Fisicaro, P., Vapalahti, O., Kallio-Kokko, H., Vaheri, A., Burton, D. R. Human recombinant puumala virus antibodies: Cross-reaction with other hantaviruses and use in diagnostics Journal of General Virology 1998 79:659-665 PMID:9568958
- Graus, Y. F., Verschuuren, J. J., Degenhardt, A., Vriesman, P. J. V., De Baets, M. H., Posner, J. B., Burton, D. R., Dalmau, J. Selection of recombinant anti-hud fab fragments from a phage display antibody library of a lung cancer patient with paraneoplastic encephalomyelitis Journal of Neuroimmunology 1998 82:200-209 DOI:10.1016/s0165-5728(97)00199-9 PMID:9585817
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- Gauduin, M. C., Parren, Pwhi, Weir, R., Barbas, C. F., Burton, D. R., Koup, R. A. Passive immunization with a human monoclonal antibody protects hu-pbl-scid mice against challenge by primary isolates of hiv-1 Nature Medicine 1997 3:1389-1393 DOI:10.1038/nm1297-1389 PMID:9396610
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- Mo, H. M., Stamatatos, L., Ip, J. E., Barbas, C. F., Parren, Pwhi, Burton, D. R., Moore, J. P., Ho, D. D. Human immunodeficiency virus type 1 mutants that escape neutralization by human monoclonal antibody igg1b12 Journal of Virology 1997 71:6869-6874 PMID:9261412 PMCID:PMC191968
- Williamson, R. A., Lazzarotto, T., Sanna, P. P., Bastidas, R. B., Casa, B. D., Campisi, G., Burioni, R., Landini, M. P., Burton, D. R. Use of recombinant human antibody fragments for detection of cytomegalovirus antigenemia Journal of Clinical Microbiology 1997 35:2047-2050 PMID:9230379 PMCID:PMC229900
- Graus, Y. F., deBaets, M. H., Vriesman, P. J. V., Burton, D. R. Anti-acetylcholine receptor fab fragments isolated from thymus-derived phage display libraries from myasthenia gravis patients reflect predominant specificities in serum and block the action of pathogenic serum antibodies Immunology Letters 1997 57:59-62 DOI:10.1016/s0165-2478(97)00046-1 PMID:9232426
- Cattani, P., Rossolini, G. M., Cresti, S., Santangelo, R., Burton, D. R., Williamson, R. A., Sanna, P. P., Fadda, G. Detection and typing of herpes simplex viruses by using recombinant immunoglobulin fragments produced in bacteria Journal of Clinical Microbiology 1997 35:1504-1509 PMID:9163470 PMCID:PMC229775
- Kessler, J. A., McKenna, P. M., Emini, E. A., Chan, C. P., Patel, M. D., Gupta, S. K., Mark, G. E., Barbas, C. F., Burton, D. R., Conley, A. J. Recombinant human monoclonal antibody igg1b12 neutralizes diverse human immunodeficiency virus type 1 primary isolates AIDS Research and Human Retroviruses 1997 13:575-582 DOI:10.1089/aid.1997.13.575 PMID:9135875
- Ditzel, H. J., Parren, Pwhi, Binley, J. M., Sodroski, J., Moore, J. P., Barbas, C. F., Burton, D. R. Mapping the protein surface of human immunodeficiency virus type 1 gp120 using human monoclonal antibodies from phage display libraries Journal of Molecular Biology 1997 267:684-695 DOI:10.1006/jmbi.1997.0912 PMID:9126846
- Graus, Y. F., deBaets, M. H., Parren, Pwhi, Berrih-Aknin, S., Wokke, J., Vriesman, P. J. V., Burton, D. R. Human anti-nicotinic acetylcholine receptor recombinant fab fragments isolated from thymus-derived phage display libraries from myasthenia gravis patients reflect predominant specificities in serum and block the action of pathogenic serum antibodies Journal of Immunology 1997 158:1919-1929 PMID:9029134
- Parren, Pwhi, Burton, D. R. Antibodies against hiv-1 from phage display libraries: Mapping of an immune response and progress towards antiviral immunotherapy Antibody Engineering 1997 65:18-56 PMID:9018871
- Parren, Pwhi, Gauduin, M. C., Koup, R. A., Poignard, P., Fisicaro, P., Burton, D. R., Sattentau, Q. J. Relevance of the antibody response against human immunodeficiency virus type 1 envelope to vaccine design Immunology Letters 1997 57:105-112 DOI:10.1016/s0165-2478(97)00043-6 PMID:9232434
- Baba, T. W., Sodroski, J., ZollaPazner, S., Gorny, M. K., Robinson, J., Posner, M. R., Katinger, H., Barbas, C. F., Burton, D. R., Chou, T. C., Ruprecht, R. M., Li, A. Synergistic neutralization of a chimeric SIV/HIV type 1 virus with combinations of human anti-HIV type 1 envelope monoclonal antibodies or hyperimmune globulins AIDS Research and Human Retroviruses 1997 13:647-656 DOI:10.1089/aid.1997.13.647 PMID:9168233
- Burton, D. R., Montefiori, D. C. The antibody response in HIV-1 infection AIDS 1997 11:S87-S98 PMID:9451972
- Parren, Pwhi, Fisicaro, P., Labrijn, A. F., Binley, J. M., Yang, W. P., Ditzel, H. J., Barbas, C. F., Burton, D. R. In vitro antigen challenge of human antibody libraries for vaccine evaluation: The human immunodeficiency virus type 1 envelope Journal of Virology 1996 70:9046-9050 PMID:8971041 PMCID:PMC191009
- Zeitlin, L., Whaley, K. J., Sanna, P. P., Moench, T. R., Bastidas, R., DeLogu, A., Williamson, R. A., Burton, D. R., Cone, R. A. Topically applied human recombinant monoclonal igg(1) antibody and its fab and f(ab')(2) fragments protect mice from vaginal transmission of hsv-2 Virology 1996 225:213-215 DOI:10.1006/viro.1996.0589 PMID:8918548
- Ditzel, H. J., Itoh, K., Burton, D. R. Determinants of polyreactivity in a large panel of recombinant human antibodies from hiv-1 infection Journal of Immunology 1996 157:739-749 PMID:8752924
- Williamson, R. A., Peretz, D., Smorodinsky, N., Bastidas, R., Serban, H., Mehlhorn, I., DeArmond, S. J., Prusiner, S. B., Burton, D. R. Circumventing tolerance to generate autologous monoclonal antibodies to the prion protein Proceedings of the National Academy of Sciences of the United States of America 1996 93:7279-7282 DOI:10.1073/pnas.93.14.7279 PMID:8692983
- Binley, J. M., Ditzel, H. J., Barbas, C. F., Sullivan, N., Sodroski, J., Parren, Pwhi, Burton, D. R. Human antibody responses to hiv type 1 glycoprotein 41 cloned in phage display libraries suggest three major epitopes are recognized and give evidence for conserved antibody motifs in antigen binding AIDS Research and Human Retroviruses 1996 12:911-924 DOI:10.1089/aid.1996.12.911 PMID:8798976
- Barbas, C. F., Burton, D. R. Selection and evolution of high-affinity human anti-viral antibodies Trends in Biotechnology 1996 14:230-234 DOI:10.1016/0167-7799(96)10029-9 PMID:8771795
- Seligman, S. J., Binley, J. M., Gorny, M. K., Burton, D. R., ZollaPazner, S., Sokolowski, K. A. Characterization by serial deletion competition elisas of hiv-1 v3 loop epitopes recognized by monoclonal antibodies Molecular Immunology 1996 33:737-745 DOI:10.1016/0161-5890(96)00044-2 PMID:8811069
- Gauduin, M. C., Allaway, G. P., Maddon, P. J., Barbas, C. F., Burton, D. R., Koup, R. A. Effective ex vivo neutralization of human immunodeficiency virus type 1 in plasma by recombinant immunoglobulin molecules Journal of Virology 1996 70:2586-2592 PMID:8642690 PMCID:PMC190106
- McKenzie, I. F. C., Osman, N., Cohney, S., Vaughan, H. A., Patton, K., Mouhtouris, E., Atkin, J. D., Elliott, E., Fodor, W. L., Squinto, S. P., Burton, D., Gallop, M. A., et al. Strategies to overcome the anti-gal alpha(1-3)gal reaction in xenotransplantation Transplantation Proceedings 1996 28:537-537 PMID:8623253
- Sanna, P. P., deLogu, A., Williamson, R. A., Hom, Y. L., Straus, S. E., Bloom, F. E., Burton, D. R. Protection of nude mice by passive immunization with a type-common human recombinant monoclonal antibody against hsv Virology 1996 215:101-106 DOI:10.1006/viro.1996.0011 PMID:8553581
- Yang, W. P., Green, K., Pinzsweeney, S., Briones, A. T., Burton, D. R., Barbas, C. F. Cdr walking mutagenesis for the affinity maturation of a potent human anti-hiv-1 antibody into the picomolar range Journal of Molecular Biology 1995 254:392-403 DOI:10.1006/jmbi.1995.0626 PMID:7490758
- Trkola, A., Pomales, A. B., Yuan, H., Korber, B., Maddon, P. J., Allaway, G. P., Katinger, H., Barbas, C. F., Burton, D. R., Ho, D. D., Moore, J. P. Cross-clade neutralization of primary isolates of human immunodeficiency virus type 1 by human monoclonal antibodies and tetrameric CD4-IgG Journal of Virology 1995 69:6609-6617 PMID:7474069 PMCID:PMC189569
- Sanna, P. P., Delogu, A., Williamson, R. A., Samson, M. E., Altieri, D. C., Bloom, F. E., Burton, D. R. Rapid assay of phage-derived recombinant human Fabs as bispecific antibodies Bio-Technology 1995 13:1221-1224 DOI:10.1038/nbt1195-1221 PMID:9636296
- Burton, D. R. Phage display Immunotechnology 1995 1:87-94 DOI:10.1016/1380-2933(95)00013-5 PMID:9373337
- Sanna, P. P., Williamson, R. A., Delogu, A., Bloom, F. E., Burton, D. R. Directed selection of recombinant human monoclonal-antibodies to herpes-simplex virus glycoproteins from phage display libraries Proceedings of the National Academy of Sciences of the United States of America 1995 92:6439-6443 DOI:10.1073/pnas.92.14.6439 PMID:7604009
- Parren, Pwhi, Ditzel, H. J., Gulizia, R. J., Binley, J. M., Barbas, C. F., Burton, D. R., Mosier, D. E. Protection against HIV-1 infection in hu-PBL-SCID mice by passive immunization with a neutralizing human monoclonal antibody against the gp120 CD4-binding site AIDS 1995 9:F1-F6 PMID:7662189
- McLane, K. E., Burton, D. R., Ghazal, P. Transplantation of a 17-amino acid alpha-helical DNA-binding domain into an antibody molecule confers sequence-dependent DNA recognition Proceedings of the National Academy of Sciences of the United States of America 1995 92:5214-5218 DOI:10.1073/pnas.92.11.5214 PMID:7761476
- Dealboran, I. M., Martinezalonso, C., Barbas, C. F., Burton, D. R., Ditzel, H. J. Human monoclonal fab fragments specific for viral-antigens from combinatorial iga libraries Immunotechnology 1995 1:21-28 DOI:10.1016/1380-2933(95)00002-x PMID:9373330
- Barbas, S. M., Ditzel, H. J., Salonen, E. M., Yang, W. P., Silverman, G. J., Burton, D. R. Human autoantibody recognition of DNA Proceedings of the National Academy of Sciences of the United States of America 1995 92:2529-2533 DOI:10.1073/pnas.92.7.2529 PMID:7708679
- Ditzel, H. J., Binley, J. M., Moore, J. P., Sodroski, J., Sullivan, N., Sawyer, L. S. W., Hendry, R. M., Yang, W. P., Barbas, C. F., Burton, D. R. Neutralizing recombinant human-antibodies to a conformational v2-binding and cd4-binding site-sensitive epitope of hiv-1 gp120 isolated by using an epitope-masking procedure Journal of Immunology 1995 154:893-906 PMID:7529290
- Moore, J. P., Cao, Y. Z., Qing, L., Sattentau, Q. J., Pyati, J., Koduri, R., Robinson, J., Barbas, C. F., Burton, D. R., Ho, D. D. Primary isolates of human-immunodeficiency-virus type-1 are relatively resistant to neutralization by monoclonal-antibodies to gp120, and their neutralization is not predicted by studies with monomeric gp120 Journal of Virology 1995 69:101-109 PMID:7527081 PMCID:PMC188553
- Burton, D. R., Barbas, C. F. Human monoclonal antibodies: Recent achievements Hospital Practice 1994 29:111, 114-116, 119 passim PMID:7962228
- Burton, D. R., Pyati, J., Koduri, R., Sharp, S. J., Thornton, G. B., Parren, Pwhi, Sawyer, L. S. W., Hendry, R. M., Dunlop, N., Nara, P. L., Lamacchia, M., Garratty, E., et al. Efficient neutralization of primary isolates of hiv-1 by a recombinant human monoclonal-antibody Science 1994 266:1024-1027 DOI:10.1126/science.7973652 PMID:7973652
- Roben, P., Moore, J. P., Thali, M., Sodroski, J., Barbas, C. F., Burton, D. R. Recognition properties of a panel of human recombinant fab fragments to the cd4 binding-site of gp120 that show differing abilities to neutralize human-immunodeficiency-virus type-1 Journal of Virology 1994 68:4821-4828 PMID:7518527 PMCID:PMC236421
- Pease, J. E., Burton, D. R., Barker, M. D. Site-directed mutagenesis of the complement c5a receptor - examination of a model for its interaction with the ligand c5a Molecular Immunology 1994 31:733-737 DOI:10.1016/0161-5890(94)90147-3 PMID:8035835
- Barbas, C. F., Hu, D., Dunlop, N., Sawyer, L., Cababa, D., Hendry, R. M., Nara, P. L., Burton, D. R. In-vitro evolution of a neutralizing human-antibody to human-immunodeficiency-virus type-1 to enhance affinity and broaden strain cross-reactivity Proceedings of the National Academy of Sciences of the United States of America 1994 91:3809-3813 PMID:8170992 PMCID:PMC43671
- Ditzel, H. J., Barbas, S. M., Barbas, C. F., Burton, D. R. The nature of the autoimmune antibody repertoire in human-immunodeficiency-virus type-1 infection Proceedings of the National Academy of Sciences of the United States of America 1994 91:3710-3714 DOI:10.1073/pnas.91.9.3710 PMID:8170974
- Barbas, S. M., Ghazal, P., Barbas, C. F., Burton, D. R. Recognition of DNA by synthetic antibodies Journal of the American Chemical Society 1994 116:2161-2162 DOI:10.1021/ja00084a073
- Crowe, J. E., Murphy, B. R., Chanock, R. M., Williamson, R. A., Barbas, C. F., Burton, D. R. Recombinant human respiratory syncytial virus (rsv) monoclonal-antibody fab is effective therapeutically when introduced directly into the lungs of rsv-infected mice Proceedings of the National Academy of Sciences of the United States of America 1994 91:1386-1390 DOI:10.1073/pnas.91.4.1386 PMID:8108420
- Burioni, R., Williamson, R. A., Sanna, P. P., Bloom, F. E., Burton, D. R. Recombinant human fab to glycoprotein-d neutralizes infectivity and prevents cell-to-cell transmission of herpes-simplex virus-1 and virus-2 in-vitro Proceedings of the National Academy of Sciences of the United States of America 1994 91:355-359 DOI:10.1073/pnas.91.1.355 PMID:8278393
- Hexham, J. M., Partridge, L. J., Furmaniak, J., Petersen, V. B., Colls, J. C., Pegg, C., Rees, S. B., Burton, D. R. Cloning and characterization of tpo autoantibodies using combinatorial phage display libraries Autoimmunity 1994 17:167-179 PMID:7524700
- Pease, J. E., Burton, D. R., Barker, M. D. Generation of chimeric c5a/formyl peptide receptors - towards the identification of the human c5a receptor-binding site European Journal of Immunology 1994 24:211-215 DOI:10.1002/eji.1830240133 PMID:8020557
- Burton, D. R., Barbas, C. F. Human-antibodies from combinatorial libraries Advances in Immunology 1994 57:191-280 DOI:10.1016/s0065-2776(08)60674-4 PMID:7872158
- Prusiner, S. B., Groth, D., Serban, A., Koehler, R., Foster, D., Torchia, M., Burton, D., Yang, S. L., Dearmond, S. J. Ablation of the prion protein (prp) gene in mice prevents scrapie and facilitates production of anti-prp antibodies Proceedings of the National Academy of Sciences of the United States of America 1993 90:10608-10612 DOI:10.1073/pnas.90.22.10608 PMID:7902565
- Sasano, M., Burton, D. R., Silverman, G. J. Molecular-selection of human-antibodies with an unconventional bacterial b-cell antigen Journal of Immunology 1993 151:5822-5839 PMID:8228264
- Soultanas, P., Andrews, P. D., Burton, D. R., Hornby, D. P. Modulation of human DNA methyltransferase activity and messenger-rna levels in the monoblast cell-line u937 induced to differentiate with dibutyryl-cyclic-amp and phorbol ester Journal of Molecular Endocrinology 1993 11:191-200 PMID:8297475
- Burton, D. R. Monoclonal antibodies from combinatorial libraries Accounts of Chemical Research 1993 26:405-411 DOI:10.1021/ar00032a003
- Chanock, R. M., Crowe, J. E., Murphy, B. R., Burton, D. R. Human monoclonal-antibody fab fragments cloned from combinatorial libraries - potential usefulness in prevention and/or treatment of major human viral diseases Infectious Agents and Disease-Reviews Issues and Commentary 1993 2:118-131 PMID:8173784
- Williamson, R. A., Burioni, R., Sanna, P. P., Partridge, L. J., Barbas, C. F., Burton, D. R. Human monoclonal-antibodies against a plethora of viral pathogens from single combinatorial libraries Proceedings of the National Academy of Sciences of the United States of America 1993 90:4141-4145 DOI:10.1073/pnas.90.9.4141 PMID:7683424
- Barbas, C. F., Collet, T. A., Amberg, W., Roben, P., Binley, J. M., Hoekstra, D., Cababa, D., Jones, T. M., Williamson, R. A., Pilkington, G. R., Haigwood, N. L., Cabezas, E., et al. Molecular profile of an antibody-response to hiv-1 as probed by combinatorial libraries Journal of Molecular Biology 1993 230:812-823 DOI:10.1006/jmbi.1993.1203 PMID:8478936
- Pease, J. E., Burton, D. R., Barker, M. D. The generation of stable cho-cell lines expressing very high-levels of complement c5a receptors and subsequent modulation of binding-affinity for c5a Biochemistry and Molecular Biology International 1993 29:339-347 PMID:8495216
- Burton, D. R., Barbas, C. F. Human-antibodies to hiv-1 by recombinant-DNA methods Chemical Immunology 1993 56:112-126 PMID:8452652
- Collet, T. A., Roben, P., Okennedy, R., Barbas, C. F., Burton, D. R., Lerner, R. A. A binary plasmid system for shuffling combinatorial antibody libraries Proceedings of the National Academy of Sciences of the United States of America 1992 89:10026-10030 DOI:10.1073/pnas.89.21.10026 PMID:1438192
- Barbas, C. F., Crowe, J. E., Cababa, D., Jones, T. M., Zebedee, S. L., Murphy, B. R., Chanock, R. M., Burton, D. R. Human monoclonal fab fragments derived from a combinatorial library bind to respiratory syncytial virus-f glycoprotein and neutralize infectivity Proceedings of the National Academy of Sciences of the United States of America 1992 89:10164-10168 PMID:1279672 PMCID:PMC50298
- Burton, D. R. Human monoclonal antibodies: achievement and potential Hospital Practice 1992 27:67-74
- Zebedee, S. L., Barbas, C. F., Hom, Y. L., Caothien, R. H., Graff, R., Degraw, J., Pyati, J., Lapolla, R., Burton, D. R., Lerner, R. A., Thornton, G. B. Human combinatorial antibody libraries to hepatitis-b surface-antigen Proceedings of the National Academy of Sciences of the United States of America 1992 89:3175-3179 DOI:10.1073/pnas.89.8.3175 PMID:1373487
- Duchosal, M. A., Eming, S. A., Fischer, P., Leturcq, D., Barbas, C. F., McConahey, P. J., Caothien, R. H., Thornton, G. B., Dixon, F. J., Burton, D. R. Immunization of hu-pbl-scid mice and the rescue of human monoclonal fab fragments through combinatorial libraries Nature 1992 355:258-262 DOI:10.1038/355258a0 PMID:1731222
- Hexham, J. M., Furmaniak, J., Pegg, C., Burton, D. R., Smith, B. R. Cloning of a human autoimmune-response - preparation and sequencing of a human antithyroglobulin autoantibody using a combinatorial approach Autoimmunity 1992 12:135-141 DOI:10.3109/08916939209150320 PMID:1617110
- Burton, D. R., Woof, J. M. Human antibody effector function Advances in Immunology 1992 51:1-84 DOI:10.1016/s0065-2776(08)60486-1 PMID:1502974
- Barbas, C. F., Bjorling, E., Chiodi, F., Dunlop, N., Cababa, D., Jones, T. M., Zebedee, S. L., Persson, M. A. A., Nara, P. L., Norrby, E., Burton, D. R. Recombinant human fab fragments neutralize human type-1 immunodeficiency virus in vitro Proceedings of the National Academy of Sciences of the United States of America 1992 89:9339-9343 PMID:1384050 PMCID:PMC50122
- Kang, A. S., Jones, T. M., Burton, D. R. Antibody redesign by chain shuffling from random combinatorial immunoglobulin libraries Proceedings of the National Academy of Sciences of the United States of America 1991 88:11120-11123 DOI:10.1073/pnas.88.24.11120 PMID:1763028
- Burton, D. R., Barbas, C. F., Persson, M. A. A., Koenig, S., Chanock, R. M., Lerner, R. A. A large array of human monoclonal-antibodies to type-1 human-immunodeficiency-virus from combinatorial libraries of asymptomatic seropositive individuals Proceedings of the National Academy of Sciences of the United States of America 1991 88:10134-10137 DOI:10.1073/pnas.88.22.10134 PMID:1719545
- Lerner, R. A., Barbas, C. F., Kang, A. S., Burton, D. R. On the use of combinatorial antibody libraries to clone the fossil record of an individuals immune-response Proceedings of the National Academy of Sciences of the United States of America 1991 88:9705-9706 DOI:10.1073/pnas.88.21.9705 PMID:1946391
- Lund, J., Winter, G., Jones, P. T., Pound, J. D., Tanaka, T., Walker, M. R., Artymiuk, P. J., Arata, Y., Burton, D. R., Jefferis, R., Woof, J. M. Human fc-gamma-ri and fc-gamma-rii interact with distinct but overlapping sites on human-igg Journal of Immunology 1991 147:2657-2662 PMID:1833457
- Williamson, R. A., Persson, M. A. A., Burton, D. R. Expression of a human monoclonal anti-(rhesus-d) fab fragment in escherichia-coli with the use of bacteriophage-lambda vectors Biochemical Journal 1991 277:561-563 PMID:1830475 PMCID:PMC1151271
- Burton, D. R. Human and mouse monoclonal-antibodies by repertoire cloning Trends in Biotechnology 1991 9:169-175 DOI:10.1016/0167-7799(91)90055-m PMID:1367284
- Sheth, B., Banks, P., Burton, D. R., Monk, P. N. The regulation of actin polymerization in differentiating u937 cells correlates with increased membrane levels of the pertussis-toxin-sensitive g-protein gi2 Biochemical Journal 1991 275:809-811 PMID:1645523 PMCID:PMC1150128
- Persson, M. A. A., Caothien, R. H., Burton, D. R. Generation of diverse high-affinity human monoclonal-antibodies by repertoire cloning Proceedings of the National Academy of Sciences of the United States of America 1991 88:2432-2436 DOI:10.1073/pnas.88.6.2432 PMID:1826052
- Blackburn, G. M., Kingsbury, G., Jayaweera, S., Burton, D. R. Expanded transition-state analogs Ciba Foundation Symposia 1991 159:211-226 PMID:1959449
- Davis, K. G., Glennie, M., Harding, S. E., Burton, D. R. A model for the solution conformation of rat ige Biochemical Society Transactions 1990 18:935-936 PMID:2083747
- Burton, D. R. Antibody - the flexible adapter molecule Trends in Biochemical Sciences 1990 15:64-69 DOI:10.1016/0968-0004(90)90178-e PMID:2186517
- Kang, A. S., Kingsbury, G. A., Blackburn, G. M., Burton, D. R. Catalytic antibodies - designer enzymes Chemistry in Britain 1990 26:128-132
- Huse, W. D., Sastry, L., Iverson, S. A., Kang, A. S., Altingmees, M., Burton, D. R., Benkovic, S. J., Lerner, R. A. Generation of a large combinatorial library of the immunoglobulin repertoire in phage-lambda Science 1989 246:1275-1281 DOI:10.1126/science.2531466 PMID:2531466
- Blackburn, G. M., Kingsbury, G. A., Burton, D. R. Catalytic antibodies Biochemical Journal 1989 262:381-390 PMID:2679548 PMCID:PMC1133279
- Burton, D., Artymiuk, P., Ford, G. Death by antibody New Scientist 1989 122:42-45
- Walker, M. R., Woof, J. M., Bruggemann, M., Jefferis, R., Burton, D. R. Interaction of human-igg chimeric antibodies with the human fcri and fcrii receptors - requirements for antibody-mediated host-cell target-cell interaction Molecular Immunology 1989 26:403-411 DOI:10.1016/0161-5890(89)90129-6 PMID:2716734
- Burton, D. R. Molecular-basis of antibody effector function Biochemical Society Transactions 1988 16:953-956 PMID:3224761
- Burton, D. R., Jefferis, R., Partridge, L. J., Woof, J. M. Molecular recognition of antibody (igg) by cellular fc receptor (fcri) Molecular Immunology 1988 25:1175-1181 DOI:10.1016/0161-5890(88)90153-8 PMID:2975762
- Woof, J. M., Burton, D. R. Microassay for measurement of binding of radiolabeled ligands to cell-surface molecules Journal of Immunological Methods 1988 111:205-207 DOI:10.1016/0022-1759(88)90128-7 PMID:2840465
- Banks, P., Barker, M. D., Burton, D. R. Recruitment of actin to the cytoskeletons of human monocyte-like cells activated by complement fragment-c5a - is protein kinase-c involved Biochemical Journal 1988 252:765-769 PMID:3421921 PMCID:PMC1149213
- Duncan, A. R., Woof, J. M., Partridge, L. J., Burton, D. R., Winter, G. Localization of the binding-site for the human high-affinity fc receptor on igg Nature 1988 332:563-564 DOI:10.1038/332563a0 PMID:2965792
- Dransfield, I., Corcoran, D., Partridge, L. J., Hogg, N., Burton, D. R. Comparison of human-monocytes isolated by elutriation and adherence suggests that heterogeneity may reflect a continuum of maturation activation states Immunology 1988 63:491-498 PMID:3350583 PMCID:PMC1454750
- Sheth, B., Dransfield, I., Partridge, L. J., Barker, M. D., Burton, D. R. Dibutyryl cyclic-amp stimulation of a monocyte-like cell-line, u937 - a model for monocyte chemotaxis and fc receptor-related functions Immunology 1988 63:483-490 PMID:2832314 PMCID:PMC1454775
- Walker, M. R., Kumpel, B. M., Thompson, K., Woof, J. M., Burton, D. R., Jefferis, R. Immunogenic and antigenic epitopes of immunoglobulins binding of human monoclonal anti-d antibodies to fcri on the monocyte-like u937 cell-line Vox Sanguinis 1988 55:222-228 PMID:2464239
- Gregory, L., Davis, K. G., Sheth, B., Boyd, J., Jefferis, R., Nave, C., Burton, D. R. The solution conformations of the subclasses of human-igg deduced from sedimentation and small-angle x-ray-scattering studies Molecular Immunology 1987 24:821-829 DOI:10.1016/0161-5890(87)90184-2 PMID:3657808
- Partridge, L. J., Woof, J. M., Jefferis, R., Burton, D. R. The use of anti-igg monoclonal-antibodies in mapping the monocyte receptor-site on igg Molecular Immunology 1986 23:1365-1372 DOI:10.1016/0161-5890(86)90022-2 PMID:2434846
- Burton, D. R. Is igm-like dislocation a common feature of antibody function Immunology Today 1986 7:165-167 DOI:10.1016/0167-5699(86)90166-0 PMID:25290200
- Barker, M. D., Jose, P. J., Williams, T. J., Burton, D. R. The chemoattractant des-arg74-c5a regulates the expression of its own receptor on a monocyte-like cell-line Biochemical Journal 1986 236:621-624 PMID:3019322
- Woof, J. M., Partridge, L. J., Jefferis, R., Burton, D. R. Localization of the monocyte-binding region on human immunoglobulin-g Molecular Immunology 1986 23:319-330 DOI:10.1016/0161-5890(86)90059-3 PMID:3487030
- Burton, D. R., Gregory, L., Jefferis, R. Aspects of the molecular-structure of igg subclasses Monographs in Allergy 1986 19:7-35 PMID:2945094
- Leatherbarrow, R. J., Rademacher, T. W., Dwek, R. A., Woof, J. M., Clark, A., Burton, D. R., Richardson, N., Feinstein, A. Effector functions of a monoclonal aglycosylated mouse igg2a - binding and activation of complement component c1 and interaction with human monocyte fc-receptor Molecular Immunology 1985 22:407-415 DOI:10.1016/0161-5890(85)90125-7 PMID:4033665
- Burton, D. R. Immunoglobulin-g - functional sites Molecular Immunology 1985 22:161-206 DOI:10.1016/0161-5890(85)90151-8 PMID:3889592
- Perkins, S. J., Villiers, C. L., Arlaud, G. J., Boyd, J., Burton, D. R., Colomb, M. G., Dwek, R. A. Neutron-scattering studies of subcomponent clq of 1st component cl of human-complement and its association with subunit clr2cls2 within cl Journal of Molecular Biology 1984 179:547-557 DOI:10.1016/0022-2836(84)90079-2 PMID:6096553
- Woof, J. M., Jaafar, M. I. N., Jefferis, R., Burton, D. R. The monocyte binding domain(s) on human immunoglobulin-g Molecular Immunology 1984 21:523-527 DOI:10.1016/0161-5890(84)90068-3 PMID:6235444
- Boyd, J., Burton, D. R., Perkins, S. J., Villiers, C. L., Dwek, R. A., Arlaud, G. J. Neutron-scattering studies of the isolated c1r2c1s2 subunit of 1st component of human-complement in solution Proceedings of the National Academy of Sciences of the United States of America 1983 80:3769-3773 DOI:10.1073/pnas.80.12.3769 PMID:6304736
- Emanuel, E. J., Brampton, A. D., Burton, D. R., Dwek, R. A. Formation of complement subcomponent c1q immunoglobulin-g complex - thermodynamic and chemical-modification studies Biochemical Journal 1982 205:361-372 PMID:6982707 PMCID:PMC1158489
- Isaksson-Forsen, G., Elgjo, K., Burton, D., Iversen, O. H. Partial purification of the epidermal G2 chalone based on an in vivo assay system Cell Biology International Reports 1981 5:195-199 DOI:10.1016/0309-1651(81)90028-x PMID:6452953
- Burton, D. R., Forsen, S., Reimarsson, P. The interaction of polyamines with DNA - a na-23 NMR-study Nucleic Acids Research 1981 9:1219-1228 DOI:10.1093/nar/9.5.1219 PMID:7232215
- Burton, D. R., Boyd, J., Brampton, A. D., Easterbrooksmith, S. B., Emanuel, E. J., Novotny, J., Rademacher, T. W., Vanschravendijk, M. R., Sternberg, M. J. E., Dwek, R. A. The c1q receptor-site on immunoglobulin-g Nature 1980 288:338-344 DOI:10.1038/288338a0 PMID:6776418
- Burton, D. R., Forsen, S., Karlstrom, G., Dwek, R. A. Proton relaxation enhancement (pre) in biochemistry - critical survey Progress in Nuclear Magnetic Resonance Spectroscopy 1979 13:1-45 DOI:10.1016/0079-6565(79)80012-6
- Burton, D. R., Forsen, S., Franek, F., Novotny, J. Proton relaxation enhancement to probe the effects of antigen-binding on pig antibody structure FEBS Letters 1979 102:249-252 DOI:10.1016/0014-5793(79)80011-3 PMID:88375
- Burton, D. R., Butler, M. J., Hyde, J. E., Phillips, D., Skidmore, C. J., Walker, I. O. Interaction of core histones with DNA - equilibrium binding studies Nucleic Acids Research 1978 5:3643-3663 DOI:10.1093/nar/5.10.3643 PMID:724497
- Burton, D. R., Reimarsson, P. Na-23 NMR as a probe of ion binding to chromatin FEBS Letters 1978 89:183-186 DOI:10.1016/0014-5793(78)80213-0 PMID:658406
- Korsgaard, R., Iversen, O. H., Isaksson-Forsen, G., Burton, D. R. Specificity of epidermal chalone extracts for human epidermoid tumour cells in vitro: a preliminary report Cell and Tissue Kinetics 1978 11:441-443 DOI:10.1111/j.1365-2184.1978.tb00816.x PMID:150948
- Burton, D. R., Forsen, S., Karlstrom, G., Dwek, R. A., McLaughlin, A. C., Wainhobson, S. Determination of molecular-motion parameters from proton-relaxation-enhancement measurements in a number of gd(iii) antibody-fragment complexes - comparative-study European Journal of Biochemistry 1977 75:445-453 DOI:10.1111/j.1432-1033.1977.tb11547.x PMID:560299
- Wright, C., Willan, K. J., Sjodahl, J., Burton, D. R., Dwek, R. A. Interaction of protein-a and fc-fragment of rabbit immunoglobulin-g as probed by complement-fixation and NMR-studies Biochemical Journal 1977 167:661-668 PMID:603628 PMCID:PMC1183712
- Burton, D. R., Dwek, R. A., Forsen, S., Karlstrom, G. Novel-approach to water proton relaxation in paramagnetic ion macromolecule complexes Biochemistry 1977 16:250-254 DOI:10.1021/bi00621a014 PMID:836785
- Isaksson-Forsen, G., Burton, D. R., Korsgaard, R., Elgjo, K., Iversen, O. H. Partial purification of epidermal G2 chalone Virchows Archiv B-Cell Pathology Including Molecular Pathology 1977 26:97-103 PMID:146951
- Korsgaard, R., Iversen, O. H., Burton, D. R., Isaksson-Forsen, G. [Species-non-specific and reversible growth inhibition by chalones in human epidermoid carcinomas in vitro] Zeitschrift für Krebsforschung und Klinische Onkologie 1977 88:217-221 DOI:10.1007/bf00305359 PMID:140538
- Burton, D. R., Forsen, S., Karlstrom, G., Dwek, R. A., McLaughlin, A. C., Wainhobson, S. Difficulties in determining accurate molecular-motion parameters from proton relaxation enhancement measurements as illustrated by immunoglobulin-g . Gd(iii) system European Journal of Biochemistry 1976 71:519-528 DOI:10.1111/j.1432-1033.1976.tb11140.x PMID:188653
- Burton, D. R., Hyde, J. E., Walker, I. O. Histones f2a1 and f3 interact reversibly and cooperatively with DNA to form an equimolar complex in chromatin FEBS Letters 1975 55:77-80 DOI:10.1016/0014-5793(75)80962-8 PMID:1170100
chapter
- Calarese, D., Scanlan, C., Lee, H. K., Rudd, P., Dwek, R. Toward a carbohydrate-based HIV-1 vaccine ACS Symposium Series. 161-185. 2006 DOI:10.1021/bk-2006-0932.ch007

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education and training

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