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Bruick, Richard Keith
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Bruick, Richard Keith

Graduate Student
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Positions

  • 2003 - Faculty Member, The University of Texas Southwestern Medical Center
  • 1999 - 2002 Postdoctoral Fellow, The University of Texas Southwestern Medical Center
  • 1991 Teaching Assistant, The University of North Carolina at Chapel Hill
  • 1990 Summer Intern, Abbott Laboratories

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  • Doctoral Dissertation
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Publications

recent publications
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  • academic article

    • Feng, Z., Zou, X., Chen, Y., Wang, H., Duan, Y., Bruick, R. K. Modulation of HIF-2α PAS-B domain contributes to physiological responses Proceedings of the National Academy of Sciences of the United States of America  2018 115:13240-13245  DOI:10.1073/pnas.1810897115  PMID:30523118  PMCID:PMC6310796
    • Souza, R. F., Bayeh, L., Spechler, S. J., Tambar, U. K., Bruick, R. K. A new paradigm for GERD pathogenesis. Not acid injury, but cytokine-mediated inflammation driven by HIF-2α: a potential role for targeting HIF-2α to prevent and treat reflux esophagitis Current Opinion in Pharmacology  2017 37:93-99  DOI:10.1016/j.coph.2017.10.004  PMID:29112883
    • Huo, X., Agoston, A. T., Dunbar, K. B., Cipher, D. J., Zhang, X., Yu, C., Cheng, E., Zhang, Q., Pham, T. H., Tambar, U. K., Bruick, R. K., Wang, D. H., et al. Hypoxia-inducible factor-2α plays a role in mediating oesophagitis in GORD Gut  2017 66:1542-1554  DOI:10.1136/gutjnl-2016-312595  PMID:27694141  PMCID:PMC5464991
    • Cho, H., Du, X., Rizzi, J. P., Liberzon, E., Chakraborty, A. A., Gao, W., Carvo, I., Signoretti, S., Bruick, R. K., Josey, J. A., Wallace, E. M., Kaelin, W. G. On-target efficacy of a HIF-2α antagonist in preclinical kidney cancer models Nature  2016 539:107-111  DOI:10.1038/nature19795  PMID:27595393  PMCID:PMC5499381
    • Chen, W., Hill, H., Christie, A., Kim, M. S., Holloman, E., Pavia-Jimenez, A., Homayoun, F., Ma, Y., Patel, N., Yell, P., Hao, G., Yousuf, Q., et al. Targeting renal cell carcinoma with a HIF-2 antagonist Nature  2016 539:112-117  DOI:10.1038/nature19796  PMID:27595394  PMCID:PMC5340502
    • Ding, M., Bruick, R. K., Yu, Y. Secreted IGFBP5 mediates mTORC1-dependent feedback inhibition of IGF-1 signalling Nature Cell Biology  2016 18:319-327  DOI:10.1038/ncb3311  PMID:26854565  PMCID:PMC5001501
    • Scheuerrnann, T. H., Stroud, D., Sleet, C. E., Bayeh, L., Shokri, C., Wang, H. Z., Caldwell, C. G., Longgood, J., MacMillan, J. B., Bruick, R. K., Gardner, K. H., Tambar, U. K. Isoform-selective and stereoselective inhibition of hypoxia inducible factor-2 Journal of Medicinal Chemistry  2015 58:5930-5941  DOI:10.1021/acs.jmedchem.5b00529  PMID:26226049
    • Ruiz, J. C., Bruick, R. K. F-box and leucine-rich repeat protein 5 (FBXL5): sensing intracellular iron and oxygen Journal of Inorganic Biochemistry  2014 133:73-77  DOI:10.1016/j.jinorgbio.2014.01.015  PMID:24508277  PMCID:PMC3959624
    • Scheuermann, T. H., Li, Q., Ma, H. W., Key, J., Zhang, L., Chen, R., Garcia, J. A., Naidoo, J., Longgood, J., Frantz, D. E., Tambar, U. K., Gardner, K. H., et al. Allosteric inhibition of hypoxia inducible factor-2 with small molecules Nature Chemical Biology  2013 9:271-276  DOI:10.1038/nchembio.1185  PMID:23434853  PMCID:PMC3604136
    • Guo, Y., Partch, C. L., Key, J., Card, P. B., Pashkov, V., Patel, A., Bruick, R. K., Wurdak, H., Gardner, K. H. Regulating the ARNT/TACC3 axis: multiple approaches to manipulating protein/protein interactions with small molecules ACS Chemical Biology  2013 8:626-635  DOI:10.1021/cb300604u  PMID:23240775  PMCID:PMC3600089
    • Rogers, J. L., Bayeh, L., Scheuermann, T. H., Longgood, J., Key, J., Naidoo, J., Melito, L., Shokri, C., Frantz, D. E., Bruick, R. K., Gardner, K. H., MacMillan, J. B., et al. Development of inhibitors of the PAS-B domain of the HIF-2α transcription factor Journal of Medicinal Chemistry  2013 56:1739-1747  DOI:10.1021/jm301847z  PMID:23363003  PMCID:PMC3676484
    • Ruiz, J. C., Walker, S. D., Anderson, S. A., Eisenstein, R. S., Bruick, R. K. F-box and leucine-rich repeat protein 5 (FBXL5) is required for maintenance of cellular and systemic iron homeostasis Journal of Biological Chemistry  2013 288:552-560  DOI:10.1074/jbc.M112.426171  PMID:23135277  PMCID:PMC3537052
    • Wang, L., Chang, J., Varghese, D., Dellinger, M., Kumar, S., Best, A. M., Ruiz, J., Bruick, R., Pena-Llopis, S., Xu, J., Babinski, D. J., Frantz, D. E., et al. A small molecule modulates Jumonji histone demethylase activity and selectively inhibits cancer growth Nature Communications  2013 4  DOI:10.1038/ncomms3035  PMID:23792809  PMCID:PMC3724450
    • Thompson, J. W., Bruick, R. K. Protein degradation and iron homeostasis Biochimica Et Biophysica Acta-Molecular Cell Research  2012 1823:1484-1490  DOI:10.1016/j.bbamcr.2012.02.003
    • Chollangi, S., Thompson, J. W., Ruiz, J. C., Gardner, K. H., Bruick, R. K. Hemerythrin-like domain within F-box and leucine-rich repeat protein 5 (FBXL5) communicates cellular iron and oxygen availability by distinct mechanisms Journal of Biological Chemistry  2012 287:23710-23717  DOI:10.1074/jbc.M112.360404  PMID:22648410  PMCID:PMC3390645
    • Thompson, J. W., Salahudeen, A. A., Chollangi, S., Ruiz, J. C., Brautigam, C. A., Makris, T. M., Lipscomb, J. D., Tomchick, D. R., Bruick, R. K. Structural and molecular characterization of iron-sensing hemerythrin-like domain within F-box and leucine-rich repeat protein 5 (FBXL5) Journal of Biological Chemistry  2012 287:7357-7365  DOI:10.1074/jbc.M111.308684  PMID:22253436  PMCID:PMC3293540
    • Nandal, A., Ruiz, J. C., Subramanian, P., Ghimire-Rijal, S., Sinnamon, R. A., Stemmler, T. L., Bruick, R. K., Philpott, C. C. Activation of the HIF prolyl hydroxylase by the iron chaperones PCBP1 and PCBP2 Cell Metabolism  2011 14:647-657  DOI:10.1016/j.cmet.2011.08.015  PMID:22055506  PMCID:PMC3361910
    • Bekeredjian, R., Walton, C. B., MacCannell, K. A., Ecker, J., Kruse, F., Outten, J. T., Sutcliffe, D., Gerard, R. D., Bruick, R. K., Shohet, R. V. Conditional HIF-1α expression produces a reversible cardiomyopathy PLoS One  2010 5  DOI:10.1371/journal.pone.0011693  PMID:20657781  PMCID:PMC2908132
    • Salahudeen, A. A., Thompson, J. W., Ruiz, J. C., Ma, H. W., Kinch, L. N., Li, Q., Grishin, N. V., Bruick, R. K. An E3 ligase possessing an iron-responsive hemerythrin domain is a regulator of iron homeostasis Science  2009 326:722-726  DOI:10.1126/science.1176326  PMID:19762597  PMCID:PMC3582197
    • Scheuermann, T. H., Tomchick, D. R., Machius, M., Guo, Y., Bruick, R. K., Gardner, K. H. Artificial ligand binding within the HIF2α PAS-B domain of the HIF2 transcription factor Proceedings of the National Academy of Sciences of the United States of America  2009 106:450-455  DOI:10.1073/pnas.0808092106  PMID:19129502  PMCID:PMC2626723
    • Salahudeen, A. A., Bruick, R. K. Maintaining Mammalian iron and oxygen homeostasis: sensors, regulation, and cross-talk Annals of the New York Academy of Sciences  2009 1177:30-38  DOI:10.1111/j.1749-6632.2009.05038.x  PMID:19845604  PMCID:PMC3586564
    • Chang, B., Chen, Y., Zhao, Y., Bruick, R. K. JMJD6 is a histone arginine demethylase Science  2007 318:444-447  DOI:10.1126/science.1145801  PMID:17947579
    • Nguyen, A. D., McDonald, J. G., Bruick, R. K., DeBose-Boyd, R. A. Hypoxia stimulates degradation of 3-hydroxy-3-methylglutaryl-coenzyme a reductase through accumulation of lanosterol and hypoxia-inducible factor-mediated induction of Insigs Journal of Biological Chemistry  2007 282:27436-27446  DOI:10.1074/jbc.M704976200  PMID:17635920
    • Ozer, A., Bruick, R. K. Non-heme dioxygenases: cellular sensors and regulators jelly rolled into one? Nature Chemical Biology  2007 3:144-153  DOI:10.1038/nchembio863  PMID:17301803
    • Scheuermann, T. H., Yang, J., Zhang, L., Gardner, K. H., Bruick, R. K. Hypoxia-inducible factors P-ER/ARNT/S-IM domains: structure and function Methods in Enzymology  2007 435:1-24  DOI:10.1016/s0076-6879(07)35001-5  PMID:17998046
    • Dann, C. E., Bruick, R. K. Dioxygenases as O-2-dependent regulators of the hypoxic response pathway Biochemical and Biophysical Research Communications  2005 338:639-647  DOI:10.1016/j.bbrc.2005.08.140
    • Yang, J., Zhang, L., Erbel, P. J. A., Gardner, K. H., Ding, K., Garcia, J. A., Bruick, R. K. Functions of the Per/ARNT/Sim domains of the hypoxia-inducible factor Journal of Biological Chemistry  2005 280:36047-36054  DOI:10.1074/jbc.M501755200  PMID:16129688
    • Ozer, A., Bruick, R. K. Regulation of HIF by prolyl hydroxylases: recruitment of the candidate tumor suppressor protein ING4 Cell Cycle  2005 4:1153-1156  DOI:10.4161/cc.4.9.2040  PMID:16096374
    • Hossain, C. F., Kim, Y. P., Baerson, S. R., Zhang, L., Bruick, R. K., Mohammed, K. A., Agarwal, A. K., Nagle, D. G., Zhou, Y. D. Saururus cernuus lignans - Potent small molecule inhibitors of hypoxia-inducible factor-1 Biochemical and Biophysical Research Communications  2005 333:1026-1033  DOI:10.1016/j.bbrc.2005.05.191  PMID:15967416  PMCID:PMC2905542
    • Ozer, A., Wu, L. C., Bruick, R. K. The candidate tumor suppressor ING4 represses activation of the hypoxia inducible factor (HIF) Proceedings of the National Academy of Sciences of the United States of America  2005 102:7481-7486  DOI:10.1073/pnas.0502716102  PMID:15897452  PMCID:PMC1140452
    • Mohammed, K. A., Hossain, C. F., Zhang, L., Bruick, R. K., Zhou, Y. D., Nagle, D. G. Laurenditerpenol, a new diterpene from the tropical marine alga Laurencia intricata that potently inhibits HIF-1 mediated hypoxic signaling in breast tumor cells Journal of Natural Products  2004 67:2002-2007  DOI:10.1021/np049753f  PMID:15620241  PMCID:PMC2910713
    • Salnikow, K., Donald, S. P., Bruick, R. K., Zhitkovich, A., Phang, J. M., Kasprzak, K. S. Depletion of intracellular ascorbate by the carcinogenic metals nickel and cobalt results in the induction of hypoxic stress Journal of Biological Chemistry  2004 279:40337-40344  DOI:10.1074/jbc.M403057200  PMID:15271983
    • degree-related publication Barnes, D., Cohen, A., Bruick, R. K., Kantardjieff, K., Fowler, S., Efuet, E., Mayfield, S. P. Identification and characterization of a novel RNA binding protein that associates with the 5 '-untranslated region of the chloroplast psbA mRNA Biochemistry  2004 43:8541-8550  DOI:10.1021/bi035909j  PMID:15222765
    • Iizuka, K., Bruick, R. K., Liang, G., Horton, J. D., Uyeda, K. Deficiency of carbohydrate response element-binding protein (ChREBP) reduces lipogenesis as well as glycolysis Proceedings of the National Academy of Sciences of the United States of America  2004 101:7281-7286  DOI:10.1073/pnas.0401516101  PMID:15118080  PMCID:PMC409910
    • Erbel, P. J. A., Card, P. B., Karakuzu, O., Bruick, R. K., Gardner, K. H. Structural basis for PAS domain heterodimerization in the basic helix-loop-helix-PAS transcription factor hypoxia-inducible factor Proceedings of the National Academy of Sciences of the United States of America  2003 100:15504-15509  DOI:10.1073/pnas.253374100  PMID:14668441  PMCID:PMC307597
    • Bruick, R. K. Oxygen sensing in the hypoxic response pathway: regulation of the hypoxia-inducible transcription factor Genes & Development  2003 17:2614-2623  DOI:10.1101/gad.1145503  PMID:14597660
    • Dann, C. E., Bruick, R. K., Deisenhofer, J. Structure of factor-inhibiting hypoxia-inducible factor 1: An asparaginyl hydroxylase involved in the hypoxic response pathway Proceedings of the National Academy of Sciences of the United States of America  2002 99:15351-15356  DOI:10.1073/pnas.202614999  PMID:12432100  PMCID:PMC137720
    • Lando, D., Peet, D. J., Gorman, J. J., Whelan, D. A., Whitelaw, M. L., Bruick, R. K. FIH-1 is an asparaginyl hydroxylase enzyme that regulates the transcriptional activity of hypoxia-inducible factor Genes & Development  2002 16:1466-1471  DOI:10.1101/gad.991402  PMID:12080085  PMCID:PMC186346
    • Bruick, R. K., McKnight, S. L. Transcription: Oxygen sensing gets a second wind Science  2002 295:807-808  DOI:10.1126/science.1069825  PMID:11823627
    • Bruick, R. K., McKnight, S. L. A conserved family of prolyl-4-hydroxylases that modify HIF Science  2001 294:1337-1340  DOI:10.1126/science.1066373  PMID:11598268
    • Bruick, R. K., McKnight, S. L. Building better vasculature Genes & Development  2001 15:2497-2502  DOI:10.1101/gad.931601  PMID:11581154
    • Yamashita, H., Takenoshita, M., Sakurai, M., Bruick, R. K., Henzel, W. J., Shillinglaw, W., Arnot, D., Uyeda, K. A glucose-responsive transcription factor that regulates carbohydrate metabolism in the liver Proceedings of the National Academy of Sciences of the United States of America  2001 98:9116-9121  DOI:10.1073/pnas.161284298  PMID:11470916  PMCID:PMC55382
    • Bruick, R. K. Expression of the gene encoding the proapoptotic Nip3 protein is induced by hypoxia Proceedings of the National Academy of Sciences of the United States of America  2000 97:9082-9087  DOI:10.1073/pnas.97.16.9082  PMID:10922063  PMCID:PMC16825
    • degree-related publication Bruick, R. K., Mayfield, S. P. Light-activated translation of chloroplast mRNAs Trends in Plant Science  1999 4:190-195  DOI:10.1016/S1360-1385(99)01402-8  PMID:10322559
    • degree-related publication Bruick, R. K., Mayfield, S. P. Processing of the psbA 5' untranslated region in Chlamydomonas reinhardtii depends upon factors mediating ribosome association Journal of Cell Biology  1998 143:1145-1153  PMID:9832545  PMCID:PMC2133069
    • degree-related publication Cohen, A., Yohn, C. B., Bruick, R. K., Mayfield, S. P. Translational regulation of chloroplast gene expression in Chlamydomonas reinhardtii Methods in Enzymology  1998 297:192-208  DOI:10.1016/S0076-6879(98)97015-X
    • degree-related publication Bruick, R. K., Koppitz, M., Joyce, G. F., Orgel, L. E. A simple procedure for constructing 5'-amino-terminated oligodeoxynucleotides in aqueous solution Nucleic Acids Research  1997 25:1309-1310  DOI:10.1093/nar/25.6.1309  PMID:9092646
    • degree-related publication Bruick, R. K., Dawson, P. E., Kent, S. B., Usman, N., Joyce, G. F. Template-directed ligation of peptides to oligonucleotides Chemistry & Biology  1996 3:49-56  DOI:10.1016/s1074-5521(96)90084-8  PMID:8807828
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Background

education and training

  • Ph.D. in Biology, Scripps Research 1992 - 1998
  • B.S. in Chemistry, The University of North Carolina at Chapel Hill 1988 - 1992

awards and honors

  • Merck Scholar Award, conferred by The University of North Carolina at Chapel Hill, 1992
  • Graduated with Highest Honors, conferred by The University of North Carolina at Chapel Hill, 1992
  • NASA Specialized Center of Research and Training (NSCORT) Adjunct Fellow, 1993 - 1998
  • National Science Foundation Graduate Research Fellowship, 1993 - 1996

advisee of

  • graduate advising relationship

    • Mayfield, Stephen, Ph.D.  candidacy, 1993 - 1998
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Contact

full name

  • Richard Keith Bruick

geographic location

  • Scripps California 
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Identity

Scopus ID

  • 6603541522

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