recent publications
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academic article
- Feng, Z., Zou, X., Chen, Y., Wang, H., Duan, Y., Bruick, R. K. Modulation of HIF-2α PAS-B domain contributes to physiological responses Proceedings of the National Academy of Sciences of the United States of America 2018 115:13240-13245 DOI:10.1073/pnas.1810897115 PMID:30523118 PMCID:PMC6310796
- Souza, R. F., Bayeh, L., Spechler, S. J., Tambar, U. K., Bruick, R. K. A new paradigm for GERD pathogenesis. Not acid injury, but cytokine-mediated inflammation driven by HIF-2α: a potential role for targeting HIF-2α to prevent and treat reflux esophagitis Current Opinion in Pharmacology 2017 37:93-99 DOI:10.1016/j.coph.2017.10.004 PMID:29112883
- Huo, X., Agoston, A. T., Dunbar, K. B., Cipher, D. J., Zhang, X., Yu, C., Cheng, E., Zhang, Q., Pham, T. H., Tambar, U. K., Bruick, R. K., Wang, D. H., et al. Hypoxia-inducible factor-2α plays a role in mediating oesophagitis in GORD Gut 2017 66:1542-1554 DOI:10.1136/gutjnl-2016-312595 PMID:27694141 PMCID:PMC5464991
- Cho, H., Du, X., Rizzi, J. P., Liberzon, E., Chakraborty, A. A., Gao, W., Carvo, I., Signoretti, S., Bruick, R. K., Josey, J. A., Wallace, E. M., Kaelin, W. G. On-target efficacy of a HIF-2α antagonist in preclinical kidney cancer models Nature 2016 539:107-111 DOI:10.1038/nature19795 PMID:27595393 PMCID:PMC5499381
- Chen, W., Hill, H., Christie, A., Kim, M. S., Holloman, E., Pavia-Jimenez, A., Homayoun, F., Ma, Y., Patel, N., Yell, P., Hao, G., Yousuf, Q., et al. Targeting renal cell carcinoma with a HIF-2 antagonist Nature 2016 539:112-117 DOI:10.1038/nature19796 PMID:27595394 PMCID:PMC5340502
- Ding, M., Bruick, R. K., Yu, Y. Secreted IGFBP5 mediates mTORC1-dependent feedback inhibition of IGF-1 signalling Nature Cell Biology 2016 18:319-327 DOI:10.1038/ncb3311 PMID:26854565 PMCID:PMC5001501
- Scheuerrnann, T. H., Stroud, D., Sleet, C. E., Bayeh, L., Shokri, C., Wang, H. Z., Caldwell, C. G., Longgood, J., MacMillan, J. B., Bruick, R. K., Gardner, K. H., Tambar, U. K. Isoform-selective and stereoselective inhibition of hypoxia inducible factor-2 Journal of Medicinal Chemistry 2015 58:5930-5941 DOI:10.1021/acs.jmedchem.5b00529 PMID:26226049
- Ruiz, J. C., Bruick, R. K. F-box and leucine-rich repeat protein 5 (FBXL5): sensing intracellular iron and oxygen Journal of Inorganic Biochemistry 2014 133:73-77 DOI:10.1016/j.jinorgbio.2014.01.015 PMID:24508277 PMCID:PMC3959624
- Scheuermann, T. H., Li, Q., Ma, H. W., Key, J., Zhang, L., Chen, R., Garcia, J. A., Naidoo, J., Longgood, J., Frantz, D. E., Tambar, U. K., Gardner, K. H., et al. Allosteric inhibition of hypoxia inducible factor-2 with small molecules Nature Chemical Biology 2013 9:271-276 DOI:10.1038/nchembio.1185 PMID:23434853 PMCID:PMC3604136
- Guo, Y., Partch, C. L., Key, J., Card, P. B., Pashkov, V., Patel, A., Bruick, R. K., Wurdak, H., Gardner, K. H. Regulating the ARNT/TACC3 axis: multiple approaches to manipulating protein/protein interactions with small molecules ACS Chemical Biology 2013 8:626-635 DOI:10.1021/cb300604u PMID:23240775 PMCID:PMC3600089
- Rogers, J. L., Bayeh, L., Scheuermann, T. H., Longgood, J., Key, J., Naidoo, J., Melito, L., Shokri, C., Frantz, D. E., Bruick, R. K., Gardner, K. H., MacMillan, J. B., et al. Development of inhibitors of the PAS-B domain of the HIF-2α transcription factor Journal of Medicinal Chemistry 2013 56:1739-1747 DOI:10.1021/jm301847z PMID:23363003 PMCID:PMC3676484
- Ruiz, J. C., Walker, S. D., Anderson, S. A., Eisenstein, R. S., Bruick, R. K. F-box and leucine-rich repeat protein 5 (FBXL5) is required for maintenance of cellular and systemic iron homeostasis Journal of Biological Chemistry 2013 288:552-560 DOI:10.1074/jbc.M112.426171 PMID:23135277 PMCID:PMC3537052
- Wang, L., Chang, J., Varghese, D., Dellinger, M., Kumar, S., Best, A. M., Ruiz, J., Bruick, R., Pena-Llopis, S., Xu, J., Babinski, D. J., Frantz, D. E., et al. A small molecule modulates Jumonji histone demethylase activity and selectively inhibits cancer growth Nature Communications 2013 4 DOI:10.1038/ncomms3035 PMID:23792809 PMCID:PMC3724450
- Thompson, J. W., Bruick, R. K. Protein degradation and iron homeostasis Biochimica Et Biophysica Acta-Molecular Cell Research 2012 1823:1484-1490 DOI:10.1016/j.bbamcr.2012.02.003
- Chollangi, S., Thompson, J. W., Ruiz, J. C., Gardner, K. H., Bruick, R. K. Hemerythrin-like domain within F-box and leucine-rich repeat protein 5 (FBXL5) communicates cellular iron and oxygen availability by distinct mechanisms Journal of Biological Chemistry 2012 287:23710-23717 DOI:10.1074/jbc.M112.360404 PMID:22648410 PMCID:PMC3390645
- Thompson, J. W., Salahudeen, A. A., Chollangi, S., Ruiz, J. C., Brautigam, C. A., Makris, T. M., Lipscomb, J. D., Tomchick, D. R., Bruick, R. K. Structural and molecular characterization of iron-sensing hemerythrin-like domain within F-box and leucine-rich repeat protein 5 (FBXL5) Journal of Biological Chemistry 2012 287:7357-7365 DOI:10.1074/jbc.M111.308684 PMID:22253436 PMCID:PMC3293540
- Nandal, A., Ruiz, J. C., Subramanian, P., Ghimire-Rijal, S., Sinnamon, R. A., Stemmler, T. L., Bruick, R. K., Philpott, C. C. Activation of the HIF prolyl hydroxylase by the iron chaperones PCBP1 and PCBP2 Cell Metabolism 2011 14:647-657 DOI:10.1016/j.cmet.2011.08.015 PMID:22055506 PMCID:PMC3361910
- Bekeredjian, R., Walton, C. B., MacCannell, K. A., Ecker, J., Kruse, F., Outten, J. T., Sutcliffe, D., Gerard, R. D., Bruick, R. K., Shohet, R. V. Conditional HIF-1α expression produces a reversible cardiomyopathy PLoS One 2010 5 DOI:10.1371/journal.pone.0011693 PMID:20657781 PMCID:PMC2908132
- Salahudeen, A. A., Thompson, J. W., Ruiz, J. C., Ma, H. W., Kinch, L. N., Li, Q., Grishin, N. V., Bruick, R. K. An E3 ligase possessing an iron-responsive hemerythrin domain is a regulator of iron homeostasis Science 2009 326:722-726 DOI:10.1126/science.1176326 PMID:19762597 PMCID:PMC3582197
- Scheuermann, T. H., Tomchick, D. R., Machius, M., Guo, Y., Bruick, R. K., Gardner, K. H. Artificial ligand binding within the HIF2α PAS-B domain of the HIF2 transcription factor Proceedings of the National Academy of Sciences of the United States of America 2009 106:450-455 DOI:10.1073/pnas.0808092106 PMID:19129502 PMCID:PMC2626723
- Salahudeen, A. A., Bruick, R. K. Maintaining Mammalian iron and oxygen homeostasis: sensors, regulation, and cross-talk Annals of the New York Academy of Sciences 2009 1177:30-38 DOI:10.1111/j.1749-6632.2009.05038.x PMID:19845604 PMCID:PMC3586564
- Chang, B., Chen, Y., Zhao, Y., Bruick, R. K. JMJD6 is a histone arginine demethylase Science 2007 318:444-447 DOI:10.1126/science.1145801 PMID:17947579
- Nguyen, A. D., McDonald, J. G., Bruick, R. K., DeBose-Boyd, R. A. Hypoxia stimulates degradation of 3-hydroxy-3-methylglutaryl-coenzyme a reductase through accumulation of lanosterol and hypoxia-inducible factor-mediated induction of Insigs Journal of Biological Chemistry 2007 282:27436-27446 DOI:10.1074/jbc.M704976200 PMID:17635920
- Ozer, A., Bruick, R. K. Non-heme dioxygenases: cellular sensors and regulators jelly rolled into one? Nature Chemical Biology 2007 3:144-153 DOI:10.1038/nchembio863 PMID:17301803
- Scheuermann, T. H., Yang, J., Zhang, L., Gardner, K. H., Bruick, R. K. Hypoxia-inducible factors P-ER/ARNT/S-IM domains: structure and function Methods in Enzymology 2007 435:1-24 DOI:10.1016/s0076-6879(07)35001-5 PMID:17998046
- Dann, C. E., Bruick, R. K. Dioxygenases as O-2-dependent regulators of the hypoxic response pathway Biochemical and Biophysical Research Communications 2005 338:639-647 DOI:10.1016/j.bbrc.2005.08.140
- Yang, J., Zhang, L., Erbel, P. J. A., Gardner, K. H., Ding, K., Garcia, J. A., Bruick, R. K. Functions of the Per/ARNT/Sim domains of the hypoxia-inducible factor Journal of Biological Chemistry 2005 280:36047-36054 DOI:10.1074/jbc.M501755200 PMID:16129688
- Ozer, A., Bruick, R. K. Regulation of HIF by prolyl hydroxylases: recruitment of the candidate tumor suppressor protein ING4 Cell Cycle 2005 4:1153-1156 DOI:10.4161/cc.4.9.2040 PMID:16096374
- Hossain, C. F., Kim, Y. P., Baerson, S. R., Zhang, L., Bruick, R. K., Mohammed, K. A., Agarwal, A. K., Nagle, D. G., Zhou, Y. D. Saururus cernuus lignans - Potent small molecule inhibitors of hypoxia-inducible factor-1 Biochemical and Biophysical Research Communications 2005 333:1026-1033 DOI:10.1016/j.bbrc.2005.05.191 PMID:15967416 PMCID:PMC2905542
- Ozer, A., Wu, L. C., Bruick, R. K. The candidate tumor suppressor ING4 represses activation of the hypoxia inducible factor (HIF) Proceedings of the National Academy of Sciences of the United States of America 2005 102:7481-7486 DOI:10.1073/pnas.0502716102 PMID:15897452 PMCID:PMC1140452
- Mohammed, K. A., Hossain, C. F., Zhang, L., Bruick, R. K., Zhou, Y. D., Nagle, D. G. Laurenditerpenol, a new diterpene from the tropical marine alga Laurencia intricata that potently inhibits HIF-1 mediated hypoxic signaling in breast tumor cells Journal of Natural Products 2004 67:2002-2007 DOI:10.1021/np049753f PMID:15620241 PMCID:PMC2910713
- Salnikow, K., Donald, S. P., Bruick, R. K., Zhitkovich, A., Phang, J. M., Kasprzak, K. S. Depletion of intracellular ascorbate by the carcinogenic metals nickel and cobalt results in the induction of hypoxic stress Journal of Biological Chemistry 2004 279:40337-40344 DOI:10.1074/jbc.M403057200 PMID:15271983
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Barnes, D., Cohen, A., Bruick, R. K., Kantardjieff, K., Fowler, S., Efuet, E., Mayfield, S. P.
Identification and characterization of a novel RNA binding protein that associates with the 5 '-untranslated region of the chloroplast psbA mRNA
Biochemistry
2004
43:8541-8550
DOI:10.1021/bi035909j
PMID:15222765
- Iizuka, K., Bruick, R. K., Liang, G., Horton, J. D., Uyeda, K. Deficiency of carbohydrate response element-binding protein (ChREBP) reduces lipogenesis as well as glycolysis Proceedings of the National Academy of Sciences of the United States of America 2004 101:7281-7286 DOI:10.1073/pnas.0401516101 PMID:15118080 PMCID:PMC409910
- Erbel, P. J. A., Card, P. B., Karakuzu, O., Bruick, R. K., Gardner, K. H. Structural basis for PAS domain heterodimerization in the basic helix-loop-helix-PAS transcription factor hypoxia-inducible factor Proceedings of the National Academy of Sciences of the United States of America 2003 100:15504-15509 DOI:10.1073/pnas.253374100 PMID:14668441 PMCID:PMC307597
- Bruick, R. K. Oxygen sensing in the hypoxic response pathway: regulation of the hypoxia-inducible transcription factor Genes & Development 2003 17:2614-2623 DOI:10.1101/gad.1145503 PMID:14597660
- Dann, C. E., Bruick, R. K., Deisenhofer, J. Structure of factor-inhibiting hypoxia-inducible factor 1: An asparaginyl hydroxylase involved in the hypoxic response pathway Proceedings of the National Academy of Sciences of the United States of America 2002 99:15351-15356 DOI:10.1073/pnas.202614999 PMID:12432100 PMCID:PMC137720
- Lando, D., Peet, D. J., Gorman, J. J., Whelan, D. A., Whitelaw, M. L., Bruick, R. K. FIH-1 is an asparaginyl hydroxylase enzyme that regulates the transcriptional activity of hypoxia-inducible factor Genes & Development 2002 16:1466-1471 DOI:10.1101/gad.991402 PMID:12080085 PMCID:PMC186346
- Bruick, R. K., McKnight, S. L. Transcription: Oxygen sensing gets a second wind Science 2002 295:807-808 DOI:10.1126/science.1069825 PMID:11823627
- Bruick, R. K., McKnight, S. L. A conserved family of prolyl-4-hydroxylases that modify HIF Science 2001 294:1337-1340 DOI:10.1126/science.1066373 PMID:11598268
- Bruick, R. K., McKnight, S. L. Building better vasculature Genes & Development 2001 15:2497-2502 DOI:10.1101/gad.931601 PMID:11581154
- Yamashita, H., Takenoshita, M., Sakurai, M., Bruick, R. K., Henzel, W. J., Shillinglaw, W., Arnot, D., Uyeda, K. A glucose-responsive transcription factor that regulates carbohydrate metabolism in the liver Proceedings of the National Academy of Sciences of the United States of America 2001 98:9116-9121 DOI:10.1073/pnas.161284298 PMID:11470916 PMCID:PMC55382
- Bruick, R. K. Expression of the gene encoding the proapoptotic Nip3 protein is induced by hypoxia Proceedings of the National Academy of Sciences of the United States of America 2000 97:9082-9087 DOI:10.1073/pnas.97.16.9082 PMID:10922063 PMCID:PMC16825
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Bruick, R. K., Mayfield, S. P.
Light-activated translation of chloroplast mRNAs
Trends in Plant Science
1999
4:190-195
DOI:10.1016/S1360-1385(99)01402-8
PMID:10322559
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Bruick, R. K., Mayfield, S. P.
Processing of the psbA 5' untranslated region in Chlamydomonas reinhardtii depends upon factors mediating ribosome association
Journal of Cell Biology
1998
143:1145-1153
PMID:9832545
PMCID:PMC2133069
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Cohen, A., Yohn, C. B., Bruick, R. K., Mayfield, S. P.
Translational regulation of chloroplast gene expression in Chlamydomonas reinhardtii
Methods in Enzymology
1998
297:192-208
DOI:10.1016/S0076-6879(98)97015-X
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Bruick, R. K., Koppitz, M., Joyce, G. F., Orgel, L. E.
A simple procedure for constructing 5'-amino-terminated oligodeoxynucleotides in aqueous solution
Nucleic Acids Research
1997
25:1309-1310
DOI:10.1093/nar/25.6.1309
PMID:9092646
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Bruick, R. K., Dawson, P. E., Kent, S. B., Usman, N., Joyce, G. F.
Template-directed ligation of peptides to oligonucleotides
Chemistry & Biology
1996
3:49-56
DOI:10.1016/s1074-5521(96)90084-8
PMID:8807828