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Bremer, Paul
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Bremer, Paul

Graduate Student
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Positions

  • 2018 - Director, Research & Development, Cessation Therapeutics
  • 2017 Research Scientist, Vertex Pharmaceuticals
  • 2016 - 2017 Research Associate, Scripps Research
  • 2007 - 2011 Undergraduate Researcher, Organometallics, Dr. Anthony Chianese, Colgate University
  • 2010 Undergraduate Researcher, National Institute of Allergy and Infectious Diseases , National Institutes of Health
  • 2009 Undergraduate Researcher, Stem Cell Research, Dr. Rita Perlingeiro, University of Minnesota

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Publications

recent publications
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  • Publications without PubMed PMIDs

  • academic article

    • Belz, T. F., Bremer, P. T., Zhou, B., Blake, S., Ellis, B., Eubanks, L. M., Janda, K. D. Sulfonate-isosteric replacement examined within heroin-hapten vaccine design Bioorganic & Medicinal Chemistry Letters  2020 30  DOI:10.1016/j.bmcl.2020.127388  PMID:32738981  PMCID:PMC7398700
    • Belz, T. F., Bremer, P. T., Zhou, B., Ellis, B., Eubanks, L. M., Janda, K. D. Enhancement of a Heroin Vaccine through Hapten Deuteration Journal of the American Chemical Society  2020 142:13294-13298  DOI:10.1021/jacs.0c05219  PMID:32700530
    • Townsend, E. A., Bremer, P. T., Faunce, K. E., Negus, S. S., Aster, A. M., Robinson, H. L., Janda, K. D., Banks, M. L. Evaluation of a Dual Fentanyl/Heroin Vaccine on the Antinociceptive and Reinforcing Effects of a Fentanyl/Heroin Mixture in Male and Female Rats ACS Chemical Neuroscience  2020 11:1300-1310  DOI:10.1021/acschemneuro.0c00064  PMID:32271538
    • Schwienteck, K. L., Blake, S., Bremer, P. T., Poklis, J. L., Townsend, E. A., Negus, S. S., Banks, M. L. Effectiveness and selectivity of a heroin conjugate vaccine to attenuate heroin, 6-acetylmorphine, and morphine antinociception in rats: Comparison with naltrexone Drug and Alcohol Dependence  2019 204  DOI:10.1016/j.drugalcdep.2019.06.006  PMID:31479865  PMCID:PMC6878171
    • Tenney, R. D., Blake, S., Bremer, P. T., Zhou, B., Hwang, C. S., Poklis, J. L., Janda, K. D., Banks, M. L. Vaccine blunts fentanyl potency in male rhesus monkeys Neuropharmacology  2019 158  DOI:10.1016/j.neuropharm.2019.107730  PMID:31369740  PMCID:PMC6745253
    • Townsend, E. A., Blake, S., Faunce, K. E., Hwang, C. S., Natori, Y., Zhou, B., Bremer, P. T., Janda, K. D., Banks, M. L. Conjugate vaccine produces long-lasting attenuation of fentanyl vs. food choice and blocks expression of opioid withdrawal-induced increases in fentanyl choice in rats Neuropsychopharmacology  2019 44:1681-1689  DOI:10.1038/s41386-019-0385-9  PMID:31043682
    • Smith, L. C., Bremer, P. T., Hwang, C. S., Zhou, B., Ellis, B., Hixon, M. S., Janda, K. D. Monoclonal antibodies for combating synthetic opioid intoxication Journal of the American Chemical Society  2019 141:10489-10503  DOI:10.1021/jacs.9b04872  PMID:31187995
    • Hwang, C. S., Bremer, P. T., Wenthur, C. J., Ho, S. O., Chiang, S., Ellis, B., Zhou, B., Fuji, G., Janda, K. D. Enhancing efficacy and stability of an antiheroin vaccine: examination of antinociception, opioid binding profile, and lethality Molecular Pharmaceutics  2018 15:1062-1072  DOI:10.1021/acs.molpharmaceut.7b00933  PMID:29420901
    • degree-related publication Bremer, P. T., Janda, K. D. Conjugate vaccine immunotherapy for substance use disorder Pharmacological Reviews  2017 69:298-315  DOI:10.1124/pr.117.013904  PMID:28634286
    • degree-related publication Bremer, P. T., Schlosburg, J. E., Banks, M. L., Steele, F. F., Zhou, B., Poklis, J. L., Janda, K. D. Development of a clinically viable heroin vaccine Journal of the American Chemical Society  2017 139:8601-8611  DOI:10.1021/jacs.7b03334  PMID:28574716
    • degree-related publication Nguyen, J. D., Bremer, P. T., Hwang, C. S., Vandewater, S. A., Collins, K. C., Creehan, K. M., Janda, K. D., Taffe, M. A. Effective active vaccination against methamphetamine in female rats Drug and Alcohol Dependence  2017 175:179-186  DOI:10.1016/j.drugalcdep.2017.03.005  PMID:28437722
    • degree-related publication Bremer, P. T., Pellett, S., Carolan, J. P., Tepp, W. H., Eubanks, L. M., Allen, K. N., Johnson, E. A., Janda, K. D. Metal ions effectively ablate the action of Botulinum neurotoxin A Journal of the American Chemical Society  2017 139:7264-7272  DOI:10.1021/jacs.7b01084  PMID:28475321
    • degree-related publication Adler, M., Phung, C. H., Singh, A. K., Janda, K. D. Newly designed quinolinol inhibitors mitigate the effects of botulinum neurotoxin A in enzymatic, cell-based, and ex vivo assays Journal of Medicinal Chemistry  2017 60:338-348  DOI:10.1021/acs.jmedchem.6b01393  PMID:27966961
    • degree-related publication Nguyen, J. D., Bremer, P. T., Ducime, A., Creehan, K. M., Kisby, B. R., Taffe, M. A., Janda, K. D. Active vaccination attenuates the psychostimulant effects of α-PVP and MDPV in rats Neuropharmacology  2016 116:1-8  DOI:10.1016/j.neuropharm.2016.12.005  PMID:27956054  PMCID:PMC5385148
    • degree-related publication Collins, K. C., Schlosburg, J. E., Bremer, P. T., Janda, K. D. Methamphetamine vaccines: improvement through hapten design Journal of Medicinal Chemistry  2016 59:3878-3885  DOI:10.1021/acs.jmedchem.6b00084  PMID:27054372
    • degree-related publication Taffe, M. A., Nguyen, J. D., Bremer, P. T., Vandewater, S. A., Creehan, K. M., Janda, K. D. Active anti-methamphetamine vaccination attenuates the effects of methamphetamine The FASEB Journal  2016 30
    • degree-related publication Bremer, P. T., Kimishima, A., Schlosburg, J. E., Zhou, B., Collins, K. C., Janda, K. D. Combatting synthetic designer opioids: a conjugate vaccine ablates lethal doses of fentanyl class drugs Angewandte Chemie-International Edition  2016 55:3772-3775  DOI:10.1002/anie.201511654  PMID:26879590  PMCID:PMC4860013
    • degree-related publication Bremer, P. T., Xue, S., Janda, K. D. Picolinic acids as β-exosite inhibitors of botulinum neurotoxin A light chain Chemical Communications  2016 52:12521-12524  DOI:10.1039/c6cc06749b  PMID:27722252  PMCID:PMC5085802
    • degree-related publication Bremer, P. T., Hixon, M. S., Janda, K. D. Benzoquinones as inhibitors of botulinum neurotoxin serotype A Bioorganic & Medicinal Chemistry  2014 22:3971-3981  DOI:10.1016/j.bmc.2014.06.004  PMID:24984937  PMCID:PMC4138410
    • degree-related publication Bremer, P. T., Schlosburg, J. E., Lively, J. M., Janda, K. D. Injection route and TLR9 agonist addition significantly impact heroin vaccine efficacy Molecular Pharmaceutics  2014 11:1075-1080  DOI:10.1021/mp400631w  PMID:24517171  PMCID:PMC3993894
    • degree-related publication Collins, K. C., Schlosburg, J. E., Lockner, J. W., Bremer, P. T., Ellis, B. A., Janda, K. D. Lipid tucaresol as an adjuvant for methamphetamine vaccine development Chemical Communications  2014 50:4079-4081  DOI:10.1039/c4cc00682h  PMID:24615284  PMCID:PMC4033696
    • degree-related publication Schlosburg, J. E., Vendruscolo, L. F., Bremer, P. T., Lockner, J. W., Wade, C. L., Nunes, A. A., Stowe, G. N., Edwards, S., Janda, K. D., Koob, G. F. Dynamic vaccine blocks relapse to compulsive intake of heroin Proceedings of the National Academy of Sciences of the United States of America  2013 110:9036-9041  DOI:10.1073/pnas.1219159110  PMID:23650354  PMCID:PMC3670323
    • Magli, A., Schnettler, E., Rinaldi, F., Bremer, P., Perlingeiro, R. C. R. Functional dissection of Pax3 in paraxial mesoderm development and myogenesis Stem Cells  2013 31:59-70  DOI:10.1002/stem.1254  PMID:23081715  PMCID:PMC3528848
    • degree-related publication Bremer, P. T., Janda, K. D. Investigating the effects of a hydrolytically stable hapten and a Th1 adjuvant on heroin vaccine performance Journal of Medicinal Chemistry  2012 55:10776-10780  DOI:10.1021/jm301262z  PMID:23134263  PMCID:PMC3527012
    • Chianese, A. R., Mo, A., Lampland, N. L., Swartz, R. L., Bremer, P. T. Iridium complexes of CCC-pincer N-heterocyclic carbene ligands: synthesis and catalytic C-H functionalization Organometallics  2010 29:3019-3026  DOI:10.1021/om100302g
    • Chianese, A. R., Bremer, P. T., Wong, C., Reynes, R. J. Rigid, sterically diverse N-heterocyclic carbene-pyridine chelates: synthesis, mild palladation, and palladium-catalyzed allylic substitution Organometallics  2009 28:5244-5252  DOI:10.1021/om900554c
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Background

education and training

  • Ph.D. in Medicinal Chemistry, Scripps Research 2011 - 2016
  • B.A. in Chemistry, Colgate University 2007 - 2011

advisee of

  • graduate advising relationship

    • Janda, Kim, Ph.D.  candidacy, 2012 - 2016
  • postdoc or fellow advising relationship

    • Janda, Kim, Ph.D.  candidacy, 2016 - 2017
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Contact

full name

  • Paul Turco Bremer

geographic location

  • Scripps California 
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Identity

ORCID iD

  • ORCID iD http://orcid.org/0000-0002-8357-1743

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