recent publications
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academic article
- Townsend, E. A., Blake, S., Faunce, K. E., Hwang, C. S., Natori, Y., Zhou, B., Bremer, P. T., Janda, K. D., Banks, M. L. Conjugate vaccine produces long-lasting attenuation of fentanyl vs. food choice and blocks expression of opioid withdrawal-induced increases in fentanyl choice in rats Neuropsychopharmacology 2019 44:1681-1689 DOI:10.1038/s41386-019-0385-9 PMID:31043682
- Smith, L. C., Bremer, P. T., Hwang, C. S., Zhou, B., Ellis, B., Hixon, M. S., Janda, K. D. Monoclonal antibodies for combating synthetic opioid intoxication Journal of the American Chemical Society 2019 141:10489-10503 DOI:10.1021/jacs.9b04872 PMID:31187995
- Tenney, R. D., Blake, S., Bremer, P. T., Zhou, B., Hwang, C. S., Poklis, J. L., Janda, K. D., Banks, M. L. Vaccine blunts fentanyl potency in male rhesus monkeys Neuropharmacology 2019 158 DOI:10.1016/j.neuropharm.2019.107730 PMID:31369740 PMCID:PMC6745253
- Hwang, C. S., Bremer, P. T., Wenthur, C. J., Ho, S. O., Chiang, S., Ellis, B., Zhou, B., Fuji, G., Janda, K. D. Enhancing efficacy and stability of an antiheroin vaccine: examination of antinociception, opioid binding profile, and lethality Molecular Pharmaceutics 2018 15:1062-1072 DOI:10.1021/acs.molpharmaceut.7b00933 PMID:29420901
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Bremer, P. T., Janda, K. D.
Conjugate vaccine immunotherapy for substance use disorder
Pharmacological Reviews
2017
69:298-315
DOI:10.1124/pr.117.013904
PMID:28634286
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Bremer, P. T., Schlosburg, J. E., Banks, M. L., Steele, F. F., Zhou, B., Poklis, J. L., Janda, K. D.
Development of a clinically viable heroin vaccine
Journal of the American Chemical Society
2017
139:8601-8611
DOI:10.1021/jacs.7b03334
PMID:28574716
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Nguyen, J. D., Bremer, P. T., Hwang, C. S., Vandewater, S. A., Collins, K. C., Creehan, K. M., Janda, K. D., Taffe, M. A.
Effective active vaccination against methamphetamine in female rats
Drug and Alcohol Dependence
2017
175:179-186
DOI:10.1016/j.drugalcdep.2017.03.005
PMID:28437722
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Bremer, P. T., Pellett, S., Carolan, J. P., Tepp, W. H., Eubanks, L. M., Allen, K. N., Johnson, E. A., Janda, K. D.
Metal ions effectively ablate the action of Botulinum neurotoxin A
Journal of the American Chemical Society
2017
139:7264-7272
DOI:10.1021/jacs.7b01084
PMID:28475321
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Adler, M., Phung, C. H., Singh, A. K., Janda, K. D.
Newly designed quinolinol inhibitors mitigate the effects of botulinum neurotoxin A in enzymatic, cell-based, and ex vivo assays
Journal of Medicinal Chemistry
2017
60:338-348
DOI:10.1021/acs.jmedchem.6b01393
PMID:27966961
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Taffe, M. A., Nguyen, J. D., Bremer, P. T., Vandewater, S. A., Creehan, K. M., Janda, K. D.
Active anti-methamphetamine vaccination attenuates the effects of methamphetamine
The FASEB Journal
2016
30
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Nguyen, J. D., Bremer, P. T., Ducime, A., Creehan, K. M., Kisby, B. R., Taffe, M. A., Janda, K. D.
Active vaccination attenuates the psychostimulant effects of α-PVP and MDPV in rats
Neuropharmacology
2016
116:1-8
DOI:10.1016/j.neuropharm.2016.12.005
PMID:27956054
PMCID:PMC5385148
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Bremer, P. T., Kimishima, A., Schlosburg, J. E., Zhou, B., Collins, K. C., Janda, K. D.
Combatting synthetic designer opioids: a conjugate vaccine ablates lethal doses of fentanyl class drugs
Angewandte Chemie-International Edition
2016
55:3772-3775
DOI:10.1002/anie.201511654
PMID:26879590
PMCID:PMC4860013
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Collins, K. C., Schlosburg, J. E., Bremer, P. T., Janda, K. D.
Methamphetamine vaccines: improvement through hapten design
Journal of Medicinal Chemistry
2016
59:3878-3885
DOI:10.1021/acs.jmedchem.6b00084
PMID:27054372
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Bremer, P. T., Xue, S., Janda, K. D.
Picolinic acids as β-exosite inhibitors of botulinum neurotoxin A light chain
Chemical Communications
2016
52:12521-12524
DOI:10.1039/c6cc06749b
PMID:27722252
PMCID:PMC5085802
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Bremer, P. T., Hixon, M. S., Janda, K. D.
Benzoquinones as inhibitors of botulinum neurotoxin serotype A
Bioorganic & Medicinal Chemistry
2014
22:3971-3981
DOI:10.1016/j.bmc.2014.06.004
PMID:24984937
PMCID:PMC4138410
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Bremer, P. T., Schlosburg, J. E., Lively, J. M., Janda, K. D.
Injection route and TLR9 agonist addition significantly impact heroin vaccine efficacy
Molecular Pharmaceutics
2014
11:1075-1080
DOI:10.1021/mp400631w
PMID:24517171
PMCID:PMC3993894
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Collins, K. C., Schlosburg, J. E., Lockner, J. W., Bremer, P. T., Ellis, B. A., Janda, K. D.
Lipid tucaresol as an adjuvant for methamphetamine vaccine development
Chemical Communications
2014
50:4079-4081
DOI:10.1039/c4cc00682h
PMID:24615284
PMCID:PMC4033696
- Magli, A., Schnettler, E., Rinaldi, F., Bremer, P., Perlingeiro, R. C. R. Functional dissection of Pax3 in paraxial mesoderm development and myogenesis Stem Cells 2013 31:59-70 DOI:10.1002/stem.1254 PMID:23081715 PMCID:PMC3528848
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Schlosburg, J. E., Vendruscolo, L. F., Bremer, P. T., Lockner, J. W., Wade, C. L., Nunes, A. A., Stowe, G. N., Edwards, S., Janda, K. D., Koob, G. F.
Dynamic vaccine blocks relapse to compulsive intake of heroin
Proceedings of the National Academy of Sciences of the United States of America
2013
110:9036-9041
DOI:10.1073/pnas.1219159110
PMID:23650354
PMCID:PMC3670323
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Bremer, P. T., Janda, K. D.
Investigating the effects of a hydrolytically stable hapten and a Th1 adjuvant on heroin vaccine performance
Journal of Medicinal Chemistry
2012
55:10776-10780
DOI:10.1021/jm301262z
PMID:23134263
PMCID:PMC3527012
- Chianese, A. R., Mo, A., Lampland, N. L., Swartz, R. L., Bremer, P. T. Iridium complexes of CCC-pincer N-heterocyclic carbene ligands: synthesis and catalytic C-H functionalization Organometallics 2010 29:3019-3026 DOI:10.1021/om100302g
- Chianese, A. R., Bremer, P. T., Wong, C., Reynes, R. J. Rigid, sterically diverse N-heterocyclic carbene-pyridine chelates: synthesis, mild palladation, and palladium-catalyzed allylic substitution Organometallics 2009 28:5244-5252 DOI:10.1021/om900554c
