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Boyce, Christopher William
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Boyce, Christopher William

Graduate Student
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Positions

  • 2013 - Medicinal Chemist, Discovery Pharmaceutical Sciences, Merck & Co., Inc.
  • 2009 - 2013 Medicinal Chemist, Merck & Co., Inc.
  • 1999 - 2009 Principal Scientist, Schering-Pough Research Institute

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Publications

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  • academic article

    • Jia, Y., Mingo, G. G., Hunter, J. C., Lieber, G. B., Palamanda, J. R., Mei, H., Boyce, C. W., Koss, M. C., Yu, Y., Cicmil, M., Hey, J. A., McLeod, R. L. Pharmacological evaluation of selective α2c-adrenergic agonists in experimental animal models of nasal congestion Journal of Pharmacology and Experimental Therapeutics  2014 349:75-84  DOI:10.1124/jpet.113.210666  PMID:24492651
    • Mauser, P. J., House, A., Jones, H., Correll, C., Boyce, C., Chapman, R. W. Pharmacological characterization of the late phase reduction in lung functions and correlations with microvascular leakage and lung edema in allergen-challenged Brown Norway rats Pulmonary Pharmacology & Therapeutics  2013 26:677-684  DOI:10.1016/j.pupt.2013.03.005  PMID:23523662
    • Zeng, Q., Rosenblum, S. B., Yang, Z., Jiang, Y., McCormick, K. D., Aslanian, R. G., Duguma, L., Kozlowski, J. A., Shih, N. Y., Hey, J. A., West, R. E., Korfmacher, W. A., et al. Synthesis and SAR studies of benzimidazolone derivatives as histamine H-3-receptor antagonists Bioorganic & Medicinal Chemistry Letters  2013 23:6001-6003  DOI:10.1016/j.bmcl.2013.08.012  PMID:24050887
    • Corboz, M. R., Rivelli, M. A., Shah, H., Boyce, C. W., McCormick, K. D., Chapman, R. W., Hunter, J. C. Role of alpha(2)-adrenoceptors in electrical field stimulation-induced contraction of pig nasal mucosa and pharmacologic characterization of a novel alpha(2C)-adrenoceptor agonist American Journal of Rhinology & Allergy  2013 27:84-90  DOI:10.2500/ajra.2013.27.3842  PMID:23562194
    • Corboz, M. R., Rivelli, M. A., McCormick, K. D., Wan, Y., Shah, H., Umland, S., Lieber, G., Jia, Y., McLeod, R. L., Morgan, C., Varty, G. B., Wu, J., et al. Pharmacological characterization of a novel α2C-adrenoceptor agonist N-[3,4-dihydro-4-(1H-imidazol-4-ylmethyl)-2H-1, 4-benzoxazin-6-yl]-N-ethyl-N'-methylurea (compound A) Journal of Pharmacology and Experimental Therapeutics  2011 337:256-266  DOI:10.1124/jpet.110.175794  PMID:21233198
    • Berlin, M., Boyce, C. W., Ruiz, M. D. Histamine H3 receptor as a drug discovery target Journal of Medicinal Chemistry  2011 54:26-53  DOI:10.1021/jm100064d  PMID:21062081
    • Berlin, M., Lee, Y. J., Boyce, C. W., Wang, Y., Aslanian, R., McCormick, K. D., Sorota, S., Williams, S. M., West, R. E., Korfmacher, W. Reduction of hERG inhibitory activity in the 4-piperidinyl urea series of H3 antagonists Bioorganic & Medicinal Chemistry Letters  2010 20:2359-2364  DOI:10.1016/j.bmcl.2010.01.121  PMID:20188550
    • Mingo, G. G., Corboz, M. R., Salisbury, B. G., McCormick, K. D., Boyce, C. W., Mukhopadhyay, G., McLeod, R. L. Alpha-2c-adrenergic receptors contribute to basal nasal patency in the anesthetized cat Pharmacology  2010 85:259-263  DOI:10.1159/000284581  PMID:20375536
    • Chan, T. M., Pramanik, B., Aslanian, R., Gullo, V., Patel, M., Cronin, B., Boyce, C., McCormick, K., Berlin, M., Zhu, X., Buevich, A., Heimark, L., et al. Isolation, structural determination, synthesis and quantitative determination of impurities in Intron-A, leached from a silicone tubing Journal of Pharmaceutical and Biomedical Analysis  2009 49:327-332  DOI:10.1016/j.jpba.2008.11.038  PMID:19150187
    • Berlin, M., Boyce, C. W. Recent advances in the development of histamine H-3 antagonists Expert Opinion on Therapeutic Patents  2007 17:675-687  DOI:10.1517/13543776.17.6.675  PMID:20144064
    • degree-related publication Boger, D. L.*, Wolkenberg, S. E.*, Boyce, C. W. A new method of in situ activation for a novel class of DNA alkylating agents: tunable metal cation complexation and activation Journal of the American Chemical Society  2000 122:6325-6326  DOI:10.1021/ja000653f (* = equal contribution)
    • degree-related publication Boger, D. L.*, Boyce, C. W.* Selective metal cation activation of a DNA alkylating agent: Synthesis and evaluation of methyl 1,2,9,9a-Tetrahydrocyclopropa c pyrido 3,2-e indol-4-one-7-carboxylate (CPyl) Journal of Organic Chemistry  2000 65:4088-4100  DOI:10.1021/jo000177b  PMID:10866626 (* = equal contribution)
    • degree-related publication Boger, D. L.*, Soenen, D. R.*, Boyce, C. W., Hedrick, M. P., Jin, Q. Total synthesis of ningalin B utilizing a heterocyclic azadiene Diels-Alder reaction and discovery of a new class of potent multidrug resistant (MDR) reversal agents Journal of Organic Chemistry  2000 65:2479-2483  DOI:10.1021/jo9916535  PMID:10789460 (* = equal contribution)
    • degree-related publication Baraldi, P. G., Cacciari, B., Romagnoli, R., Spalluto, G., Boyce, C. W., Boger, D. L. Resolution of a CPzl precursor, synthesis and biological evaluation of (+) and (-)-NBoc-CPzl: a further validation of the relationship between chemical solvolytic stability and cytotoxicity Bioorganic & Medicinal Chemistry Letters  1999 9:3087-3092  DOI:10.1016/s0960-894x(99)00533-8  PMID:10560730
    • degree-related publication Boger, D. L.*, Boyce, C. W.*, Labroli, M. A., Sehon, C. A., Jin, Q. Total syntheses of ningalin A, lamellarin O, lukianol A, and permethyl storniamide A utilizing heterocyclic azadiene Diels-Alder reactions Journal of the American Chemical Society  1999 121:54-62  DOI:10.1021/ja982078+ (* = equal contribution)
    • degree-related publication Boger, D. L.*, Boyce, C. W.*, Garbaccio, R. M., Searcey, M., Jin, Q. CBI prodrug analogs of CC-1065 and the duocarmycins Synthesis-Stuttgart  1999 1505-1509 (* = equal contribution)
    • degree-related publication Boger, D. L.*, Boyce, C. W.*, Garbaccio, R. M., Searcey, M. Synthesis of CC-1065 and duocarmycin analogs via intramolecular aryl radical cyclization of a tethered vinyl chloride Tetrahedron Letters  1998 39:2227-2230  DOI:10.1016/s0040-4039(98)00232-9 (* = equal contribution)
    • degree-related publication Boger, D. L., McKie, J. A., Boyce, C. W. Asymmetric synthesis of the CBI alkylation subunit of the CC-1065 and duocarmycin analogs Synlett  1997 515-517
    • degree-related publication Boger, D. L.*, Boyce, C. W.*, Garbaccio, R. M., Goldberg, J. A. CC-1065 and the duocarmycins: Synthetic studies Chemical Reviews  1997 97:787-828  DOI:10.1021/cr960095g  PMID:11848889 (* = equal contribution)
    • degree-related publication Boger, D. L.*, Boyce, C. W.*, Johnson, D. S. pH dependence of the rate of DNA alkylation for (+)-duocarmycin SA and (+)-CCBI-TMI Bioorganic & Medicinal Chemistry Letters  1997 7:233-238  DOI:10.1016/s0960-894x(96)00605-1 (* = equal contribution)
    • degree-related publication Boger, D. L., Han, N. H., Tarby, C. M., Boyce, C. W., Cai, H., Jin, Q., Kitos, P. A. Synthesis, chemical properties, and preliminary evaluation of substituted CBI analogs of CC-1065 and the duocarmycins incorporating the 7-cyano-1,2,9,9a-tetrahydrocyclopropa c benz e indol-4-one alkylation subunit: Hammett quantitation of the magnitude of electronic effects on functional reactivity Journal of Organic Chemistry  1996 61:4894-4912  DOI:10.1021/jo9605298
    • Boyce, C. W., Gillies, C. W., Warner, H., Gillies, J. Z., Lovas, F. J., Suenram, R. D. Microwave spectra, structure, and electric dipole moment of the Ar-isocyanic acid van der Waals complex Journal of Molecular Spectroscopy  1995 171:533-545  DOI:10.1006/jmsp.1995.1140
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Background

education and training

  • Ph.D. in Organic Chemistry, Medicinal Chemistry, Scripps Research 1994 - 1999
  • B.S. in Chemistry, Rensselaer Polytechnic Institute 1990 - 1994
  • Swiss Federal Institute of Technology Zurich (ETH) , Exchange, Chemistry 1992 - 1993

advisee of

  • graduate advising relationship

    • Boger, Dale, Ph.D.  candidacy, 1995 - 1999
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Contact

full name

  • Christopher William Boyce

geographic location

  • Scripps California 

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