recent publications
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academic article
- Jia, Y., Mingo, G. G., Hunter, J. C., Lieber, G. B., Palamanda, J. R., Mei, H., Boyce, C. W., Koss, M. C., Yu, Y., Cicmil, M., Hey, J. A., McLeod, R. L. Pharmacological evaluation of selective α2c-adrenergic agonists in experimental animal models of nasal congestion Journal of Pharmacology and Experimental Therapeutics 2014 349:75-84 DOI:10.1124/jpet.113.210666 PMID:24492651
- Mauser, P. J., House, A., Jones, H., Correll, C., Boyce, C., Chapman, R. W. Pharmacological characterization of the late phase reduction in lung functions and correlations with microvascular leakage and lung edema in allergen-challenged Brown Norway rats Pulmonary Pharmacology & Therapeutics 2013 26:677-684 DOI:10.1016/j.pupt.2013.03.005 PMID:23523662
- Corboz, M. R., Rivelli, M. A., Shah, H., Boyce, C. W., McCormick, K. D., Chapman, R. W., Hunter, J. C. Role of alpha(2)-adrenoceptors in electrical field stimulation-induced contraction of pig nasal mucosa and pharmacologic characterization of a novel alpha(2C)-adrenoceptor agonist American Journal of Rhinology & Allergy 2013 27:84-90 DOI:10.2500/ajra.2013.27.3842 PMID:23562194
- Zeng, Q., Rosenblum, S. B., Yang, Z., Jiang, Y., McCormick, K. D., Aslanian, R. G., Duguma, L., Kozlowski, J. A., Shih, N. Y., Hey, J. A., West, R. E., Korfmacher, W. A., et al. Synthesis and SAR studies of benzimidazolone derivatives as histamine H-3-receptor antagonists Bioorganic & Medicinal Chemistry Letters 2013 23:6001-6003 DOI:10.1016/j.bmcl.2013.08.012 PMID:24050887
- Berlin, M., Boyce, C. W., Ruiz, M. D. Histamine H3 receptor as a drug discovery target Journal of Medicinal Chemistry 2011 54:26-53 DOI:10.1021/jm100064d PMID:21062081
- Corboz, M. R., Rivelli, M. A., McCormick, K. D., Wan, Y., Shah, H., Umland, S., Lieber, G., Jia, Y., McLeod, R. L., Morgan, C., Varty, G. B., Wu, J., et al. Pharmacological characterization of a novel α2C-adrenoceptor agonist N-[3,4-dihydro-4-(1H-imidazol-4-ylmethyl)-2H-1, 4-benzoxazin-6-yl]-N-ethyl-N'-methylurea (compound A) Journal of Pharmacology and Experimental Therapeutics 2011 337:256-266 DOI:10.1124/jpet.110.175794 PMID:21233198
- Mingo, G. G., Corboz, M. R., Salisbury, B. G., McCormick, K. D., Boyce, C. W., Mukhopadhyay, G., McLeod, R. L. Alpha-2c-adrenergic receptors contribute to basal nasal patency in the anesthetized cat Pharmacology 2010 85:259-263 DOI:10.1159/000284581 PMID:20375536
- Berlin, M., Lee, Y. J., Boyce, C. W., Wang, Y., Aslanian, R., McCormick, K. D., Sorota, S., Williams, S. M., West, R. E., Korfmacher, W. Reduction of hERG inhibitory activity in the 4-piperidinyl urea series of H3 antagonists Bioorganic & Medicinal Chemistry Letters 2010 20:2359-2364 DOI:10.1016/j.bmcl.2010.01.121 PMID:20188550
- Chan, T. M., Pramanik, B., Aslanian, R., Gullo, V., Patel, M., Cronin, B., Boyce, C., McCormick, K., Berlin, M., Zhu, X., Buevich, A., Heimark, L., et al. Isolation, structural determination, synthesis and quantitative determination of impurities in Intron-A, leached from a silicone tubing Journal of Pharmaceutical and Biomedical Analysis 2009 49:327-332 DOI:10.1016/j.jpba.2008.11.038 PMID:19150187
- Berlin, M., Boyce, C. W. Recent advances in the development of histamine H-3 antagonists Expert Opinion on Therapeutic Patents 2007 17:675-687 DOI:10.1517/13543776.17.6.675 PMID:20144064
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Boger, D. L.*, Wolkenberg, S. E.*, Boyce, C. W.
A new method of in situ activation for a novel class of DNA alkylating agents: tunable metal cation complexation and activation
Journal of the American Chemical Society
2000
122:6325-6326
DOI:10.1021/ja000653f
(* = equal contribution)
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Boger, D. L.*, Boyce, C. W.*
Selective metal cation activation of a DNA alkylating agent: Synthesis and evaluation of methyl 1,2,9,9a-Tetrahydrocyclopropa c pyrido 3,2-e indol-4-one-7-carboxylate (CPyl)
Journal of Organic Chemistry
2000
65:4088-4100
DOI:10.1021/jo000177b
PMID:10866626
(* = equal contribution)
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Boger, D. L.*, Soenen, D. R.*, Boyce, C. W., Hedrick, M. P., Jin, Q.
Total synthesis of ningalin B utilizing a heterocyclic azadiene Diels-Alder reaction and discovery of a new class of potent multidrug resistant (MDR) reversal agents
Journal of Organic Chemistry
2000
65:2479-2483
DOI:10.1021/jo9916535
PMID:10789460
(* = equal contribution)
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Boger, D. L.*, Boyce, C. W.*, Garbaccio, R. M., Searcey, M., Jin, Q.
CBI prodrug analogs of CC-1065 and the duocarmycins
Synthesis-Stuttgart
1999
1505-1509
(* = equal contribution)
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Baraldi, P. G., Cacciari, B., Romagnoli, R., Spalluto, G., Boyce, C. W., Boger, D. L.
Resolution of a CPzl precursor, synthesis and biological evaluation of (+) and (-)-NBoc-CPzl: a further validation of the relationship between chemical solvolytic stability and cytotoxicity
Bioorganic & Medicinal Chemistry Letters
1999
9:3087-3092
DOI:10.1016/s0960-894x(99)00533-8
PMID:10560730
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Boger, D. L.*, Boyce, C. W.*, Labroli, M. A., Sehon, C. A., Jin, Q.
Total syntheses of ningalin A, lamellarin O, lukianol A, and permethyl storniamide A utilizing heterocyclic azadiene Diels-Alder reactions
Journal of the American Chemical Society
1999
121:54-62
DOI:10.1021/ja982078+
(* = equal contribution)
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Boger, D. L.*, Boyce, C. W.*, Garbaccio, R. M., Searcey, M.
Synthesis of CC-1065 and duocarmycin analogs via intramolecular aryl radical cyclization of a tethered vinyl chloride
Tetrahedron Letters
1998
39:2227-2230
DOI:10.1016/s0040-4039(98)00232-9
(* = equal contribution)
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Boger, D. L., McKie, J. A., Boyce, C. W.
Asymmetric synthesis of the CBI alkylation subunit of the CC-1065 and duocarmycin analogs
Synlett
1997
515-517
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Boger, D. L.*, Boyce, C. W.*, Garbaccio, R. M., Goldberg, J. A.
CC-1065 and the duocarmycins: Synthetic studies
Chemical Reviews
1997
97:787-828
DOI:10.1021/cr960095g
PMID:11848889
(* = equal contribution)
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Boger, D. L.*, Boyce, C. W.*, Johnson, D. S.
pH dependence of the rate of DNA alkylation for (+)-duocarmycin SA and (+)-CCBI-TMI
Bioorganic & Medicinal Chemistry Letters
1997
7:233-238
DOI:10.1016/s0960-894x(96)00605-1
(* = equal contribution)
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Boger, D. L., Han, N. H., Tarby, C. M., Boyce, C. W., Cai, H., Jin, Q., Kitos, P. A.
Synthesis, chemical properties, and preliminary evaluation of substituted CBI analogs of CC-1065 and the duocarmycins incorporating the 7-cyano-1,2,9,9a-tetrahydrocyclopropa c benz e indol-4-one alkylation subunit: Hammett quantitation of the magnitude of electronic effects on functional reactivity
Journal of Organic Chemistry
1996
61:4894-4912
DOI:10.1021/jo9605298
- Boyce, C. W., Gillies, C. W., Warner, H., Gillies, J. Z., Lovas, F. J., Suenram, R. D. Microwave spectra, structure, and electric dipole moment of the Ar-isocyanic acid van der Waals complex Journal of Molecular Spectroscopy 1995 171:533-545 DOI:10.1006/jmsp.1995.1140