Boldt, Grant E

Graduate Student

Positions

2017 - Executive Vice President, BioPharma Production Solutions, Avantor
2015 - 2017 Senior Vice President & Business Unit Head forMammalian Manufacturing, Lonza
2014 - 2015 Vice President, Research Pharmaceuticals, Sigma-Aldrich
2011 - 2014 Director, Commercial Life Sciences, Sigma-Aldrich
2009 - 2011 Manager, U.S. Sales, Bachem
2007 - 2010 Assistant Director, Scripps-Oxford Laboratory, University of Oxford

Websites

Doctoral Dissertation

Publications
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academic article
- Nieva, J., Song, B. D., Rogel, J. K., Kujawara, D., Altobel, L., Izharrudin, A., Boldt, G. E., Grover, R., Wentworth, A. D., Wentworth, P. Cholesterol secosterol aldehydes induce amyloidogenesis and dysfunction of wild-type tumor protein p53 Chemistry & Biology 2011 18:920-927 DOI:10.1016/j.chembiol.2011.02.018 PMID:21802012 PMCID:PMC3148486
- Cole, M. A., Tully, S. E., Dodds, A. W., Arnold, J. N., Boldt, G. E., Sim, R. B., Offer, J., Wentworth, P. A chemical approach to immunoprotein engineering: Chemoselective functionalization of thioester proteins in their native state ChemBioChem 2009 10:1340-1343 DOI:10.1002/cbic.200900168 PMID:19402090
- Witter, D. P., Chen, Y. P., Rogel, J. K., Boldt, G. E., Wentworth, P. The natural products beauveriolide I and III: A new class of β-amyloid-lowering compounds ChemBioChem 2009 10:1344-1347 DOI:10.1002/cbic.200900139 PMID:19396893 PMCID:PMC2812801
- Scheinost, J. C., Witter, D. P., Boldt, G. E., Offer, J., Wentworth, P. Cholesterol secosterol adduction inhibits the misfolding of a mutant prion protein fragment that induces neurodegeneration Angewandte Chemie-International Edition 2009 48:9469-9472 DOI:10.1002/anie.200904524 PMID:19899085 PMCID:PMC2837945
- Scheinost, J. C., Wang, H., Boldt, G. E., Offer, J., Wentworth, P. Cholesterol seco-sterol-induced aggregation of methylated amyloid-β peptides - insights into aldehyde-initiated fibrillization of amyloid-β Angewandte Chemie-International Edition 2008 47:3919-3922 DOI:10.1002/anie.200705922 PMID:18404766
- Silvaggi, N. R., Boldt, G. E., Hixon, M. S., Kennedy, J. P., Tzipori, S., Janda, K. D., Allen, K. N. Structures of clostridium botulinum neurotoxin serotype A light chain complexed with small-molecule inhibitors highlight active-site flexibility Chemistry & Biology 2007 14:533-542 DOI:10.1016/j.chembiol.2007.03.014 PMID:17524984
- Fu, Z. J., Chen, S., Baldwin, M. R., Boldt, G. E., Crawford, A., Janda, K. D., Barbieri, J. T., Kim, J. J. P. Light chain of botulinum neurotoxin serotype A: Structural resolution of a catalytic intermediate Biochemistry 2006 45:8903-8911 DOI:10.1021/bi060786z PMID:16846233
- Xu, Y., Lu, H., Kennedy, J. P., Yan, X. X., McAllister, L. A., Yamamoto, N., Moss, J. A., Boldt, G. E., Jiang, S. B., Janda, K. D. Evaluation of "credit card" libraries for inhibition of HIV-1 gp41 fusogenic core formation Journal of Combinatorial Chemistry 2006 8:531-539 DOI:10.1021/cc0600167 PMID:16827565 PMCID:PMC2529179
- Boldt, G. E., Kennedy, J. P., Hixon, M. S., McAllister, L. A., Barbieri, J. T., Tzipori, S., Janda, K. D. Synthesis, characterization and development of a high-throughput methodology for the discovery of botulinum neurotoxin A inhibitors Journal of Combinatorial Chemistry 2006 8:513-521 DOI:10.1021/cc060010h PMID:16827563 PMCID:PMC2644723
- Boldt, G. E., Kennedy, J. P., Janda, K. D. Identification of a potent botulinum neurotoxin a protease inhibitor using in situ lead identification chemistry Organic Letters 2006 8:1729-1732 DOI:10.1021/ol0603211 PMID:16597152 PMCID:PMC2733786
- Boldt, G. E., Dickerson, T. J., Janda, K. D. Emerging chemical and biological approaches for the preparation of discovery libraries Drug Discovery Today 2006 11:143-148 DOI:10.1016/s1359-6446(05)03697-4 PMID:16533712
- Zhang, L. G., Long, H., Boldt, G. E., Janda, K. D., Schatz, G. C., Lewis, F. D. α- and β-Stilbenosides as base-pair surrogates in DNA hairpins Organic & Biomolecular Chemistry 2006 4:314-322 DOI:10.1039/b513694f PMID:16391774
- Boldt, G. E., Eubanks, L. M., Janda, K. D. Identification of A botulinum neurotoxin a protease inhibitor displaying efficacy in a cellular model Chemical Communications 2006 3063-3065 DOI:10.1039/b603099h PMID:16855686
- Miranda-Soto, V., Parra-Hake, M., Morales-Morales, D., Toscano, R. A., Boldt, G., Koch, A., Grotjahn, D. B. A binding pocket for coordinated water formed by the metal center and two heterocyclic nitrogens in chelating bis-thioethers of the complexes {Cp*M[Im'S(CH2)(2)SIm'](H2O}(2+) (M = Rh, Ir; Im' = 1-alkyl-4-tert-butylimidazol-2-yl) Organometallics 2005 24:5569-5575 DOI:10.1021/om050448e
- Brogan, A. P., Dickerson, T. J., Boldt, G. E., Janda, K. D. Altered retinoid homeostasis catalyzed by a nicotine metabolite: Implications in macular degenerationand and normal development Proceedings of the National Academy of Sciences of the United States of America 2005 102:10433-10438 DOI:10.1073/pnas.0504721102 PMID:16014706 PMCID:PMC1180800
- Reed, N. N., Dickerson, T. J., Boldt, G. E., Janda, K. D. Enantioreversal in the sharpless asymmetric epoxidation reaction controlled by the molecular weight of a covalently appended achiral polymer Journal of Organic Chemistry 2005 70:1728-1731 DOI:10.1021/jo048009x PMID:15730294
- McKenzie, K. M., Meijler, M. M., Lowery, C. A., Boldt, G. E., Janda, K. D. A furanosyl-carbonate autoinducer in cell-to-cell communication of v-harveyi Chemical Communications 2005 4863-4865 DOI:10.1039/b509396a