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Boldt, Grant E
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Boldt, Grant E

Graduate Student
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Positions

  • 2017 - Executive Vice President, BioPharma Production Solutions, Avantor
  • 2015 - 2017 Senior Vice President & Business Unit Head forMammalian Manufacturing, Lonza
  • 2014 - 2015 Vice President, Research Pharmaceuticals, Sigma-Aldrich
  • 2011 - 2014 Director, Commercial Life Sciences, Sigma-Aldrich
  • 2009 - 2011 Manager, U.S. Sales, Bachem
  • 2007 - 2010 Assistant Director, Scripps-Oxford Laboratory, University of Oxford

Websites

  • Doctoral Dissertation
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Publications

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  • academic article

    • degree-related publication Nieva, J., Song, B. D., Rogel, J. K., Kujawara, D., Altobel, L., Izharrudin, A., Boldt, G. E., Grover, R., Wentworth, A. D., Wentworth, P. Cholesterol secosterol aldehydes induce amyloidogenesis and dysfunction of wild-type tumor protein p53 Chemistry & Biology  2011 18:920-927  DOI:10.1016/j.chembiol.2011.02.018  PMID:21802012  PMCID:PMC3148486
    • degree-related publication Cole, M. A., Tully, S. E., Dodds, A. W., Arnold, J. N., Boldt, G. E., Sim, R. B., Offer, J., Wentworth, P. A chemical approach to immunoprotein engineering: Chemoselective functionalization of thioester proteins in their native state ChemBioChem  2009 10:1340-1343  DOI:10.1002/cbic.200900168  PMID:19402090
    • degree-related publication Witter, D. P., Chen, Y. P., Rogel, J. K., Boldt, G. E., Wentworth, P. The natural products beauveriolide I and III: A new class of β-amyloid-lowering compounds ChemBioChem  2009 10:1344-1347  DOI:10.1002/cbic.200900139  PMID:19396893  PMCID:PMC2812801
    • degree-related publication Scheinost, J. C., Witter, D. P., Boldt, G. E., Offer, J., Wentworth, P. Cholesterol secosterol adduction inhibits the misfolding of a mutant prion protein fragment that induces neurodegeneration Angewandte Chemie-International Edition  2009 48:9469-9472  DOI:10.1002/anie.200904524  PMID:19899085  PMCID:PMC2837945
    • degree-related publication Scheinost, J. C., Wang, H., Boldt, G. E., Offer, J., Wentworth, P. Cholesterol seco-sterol-induced aggregation of methylated amyloid-β peptides - insights into aldehyde-initiated fibrillization of amyloid-β Angewandte Chemie-International Edition  2008 47:3919-3922  DOI:10.1002/anie.200705922  PMID:18404766
    • degree-related publication Silvaggi, N. R., Boldt, G. E., Hixon, M. S., Kennedy, J. P., Tzipori, S., Janda, K. D., Allen, K. N. Structures of clostridium botulinum neurotoxin serotype A light chain complexed with small-molecule inhibitors highlight active-site flexibility Chemistry & Biology  2007 14:533-542  DOI:10.1016/j.chembiol.2007.03.014  PMID:17524984
    • degree-related publication Fu, Z. J., Chen, S., Baldwin, M. R., Boldt, G. E., Crawford, A., Janda, K. D., Barbieri, J. T., Kim, J. J. P. Light chain of botulinum neurotoxin serotype A: Structural resolution of a catalytic intermediate Biochemistry  2006 45:8903-8911  DOI:10.1021/bi060786z  PMID:16846233
    • degree-related publication Xu, Y., Lu, H., Kennedy, J. P., Yan, X. X., McAllister, L. A., Yamamoto, N., Moss, J. A., Boldt, G. E., Jiang, S. B., Janda, K. D. Evaluation of "credit card" libraries for inhibition of HIV-1 gp41 fusogenic core formation Journal of Combinatorial Chemistry  2006 8:531-539  DOI:10.1021/cc0600167  PMID:16827565  PMCID:PMC2529179
    • degree-related publication Boldt, G. E., Kennedy, J. P., Hixon, M. S., McAllister, L. A., Barbieri, J. T., Tzipori, S., Janda, K. D. Synthesis, characterization and development of a high-throughput methodology for the discovery of botulinum neurotoxin A inhibitors Journal of Combinatorial Chemistry  2006 8:513-521  DOI:10.1021/cc060010h  PMID:16827563  PMCID:PMC2644723
    • degree-related publication Boldt, G. E., Kennedy, J. P., Janda, K. D. Identification of a potent botulinum neurotoxin a protease inhibitor using in situ lead identification chemistry Organic Letters  2006 8:1729-1732  DOI:10.1021/ol0603211  PMID:16597152  PMCID:PMC2733786
    • degree-related publication Boldt, G. E., Dickerson, T. J., Janda, K. D. Emerging chemical and biological approaches for the preparation of discovery libraries Drug Discovery Today  2006 11:143-148  DOI:10.1016/s1359-6446(05)03697-4  PMID:16533712
    • degree-related publication Zhang, L. G., Long, H., Boldt, G. E., Janda, K. D., Schatz, G. C., Lewis, F. D. α- and β-Stilbenosides as base-pair surrogates in DNA hairpins Organic & Biomolecular Chemistry  2006 4:314-322  DOI:10.1039/b513694f  PMID:16391774
    • degree-related publication Boldt, G. E., Eubanks, L. M., Janda, K. D. Identification of A botulinum neurotoxin a protease inhibitor displaying efficacy in a cellular model Chemical Communications  2006 3063-3065  DOI:10.1039/b603099h  PMID:16855686
    • Miranda-Soto, V., Parra-Hake, M., Morales-Morales, D., Toscano, R. A., Boldt, G., Koch, A., Grotjahn, D. B. A binding pocket for coordinated water formed by the metal center and two heterocyclic nitrogens in chelating bis-thioethers of the complexes {Cp*M[Im'S(CH2)(2)SIm'](H2O}(2+) (M = Rh, Ir; Im' = 1-alkyl-4-tert-butylimidazol-2-yl) Organometallics  2005 24:5569-5575  DOI:10.1021/om050448e
    • degree-related publication Brogan, A. P., Dickerson, T. J., Boldt, G. E., Janda, K. D. Altered retinoid homeostasis catalyzed by a nicotine metabolite: Implications in macular degenerationand and normal development Proceedings of the National Academy of Sciences of the United States of America  2005 102:10433-10438  DOI:10.1073/pnas.0504721102  PMID:16014706  PMCID:PMC1180800
    • degree-related publication Reed, N. N., Dickerson, T. J., Boldt, G. E., Janda, K. D. Enantioreversal in the sharpless asymmetric epoxidation reaction controlled by the molecular weight of a covalently appended achiral polymer Journal of Organic Chemistry  2005 70:1728-1731  DOI:10.1021/jo048009x  PMID:15730294
    • degree-related publication McKenzie, K. M., Meijler, M. M., Lowery, C. A., Boldt, G. E., Janda, K. D. A furanosyl-carbonate autoinducer in cell-to-cell communication of v-harveyi Chemical Communications  2005 4863-4865  DOI:10.1039/b509396a
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Background

education and training

  • Ph.D. in Chemical Biology, Scripps Research 2004 - 2007
  • M.S. in Chemistry, San Diego State University 2002 - 2003
  • B.S. in Chemistry, San Diego State University 1998 - 2002

advisee of

  • graduate advising relationship

    • Janda, Kim, Ph.D.  candidacy, 2005 - 2007
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Contact

full name

  • Grant E Boldt

geographic location

  • Scripps California 

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