recent publications
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academic article
- Cornelissen, J. C., Blough, B. E., Bohn, L. M., Negus, S. S., Banks, M. L. Some effects of putative G-protein biased mu-opioid receptor agonists in male rhesus monkeys Behavioural Pharmacology 2021 32:453-458 DOI:10.1097/fbp.0000000000000634 PMID:33883450 PMCID:PMC8266741
- Stahl, E. L., Bohn, L. M. Decaf or regular? Energizing the caffeine receptor Cell 2021 184:1659-1660 DOI:10.1016/j.cell.2021.03.016 PMID:33798438
- Jiang, S., Iliopoulos-Tsoutsouvas, C., Tong, F., Brust, C. A., Keenan, C. M., Raghav, J. G., Hua, T., Wu, S. M., Ho, J. H., Wu, Y. R., Grim, T. W., Zvonok, N., et al. Novel Functionalized Cannabinoid Receptor Probes: Development of Exceptionally Potent Agonists Journal of Medicinal Chemistry 2021 64:3870-3884 DOI:10.1021/acs.jmedchem.0c02053 PMID:33761251
- Wang, X. Y., Liu, D. S., Shen, L., Li, F. H., Li, Y. Z., Yang, L. Y., Xu, T. D., Tao, H. C., Yao, D. Q., Wu, L. J., Hirata, K., Bohn, L. M., et al. A Genetically Encoded F-19 NMR Probe Reveals the Allosteric Modulation Mechanism of Cannabinoid Receptor 1 Journal of the American Chemical Society 2021 143:16320-16325 DOI:10.1021/jacs.1c06847 PMID:34596399
- Stahl, E. L., Schmid, C. L., Acevedo-Canabal, A., Read, C., Grim, T. W., Kennedy, N. M., Bannister, T. D., Bohn, L. M. G protein signaling-biased mu opioid receptor agonists that produce sustained G protein activation are noncompetitive agonists Proceedings of the National Academy of Sciences of the United States of America 2021 118 DOI:10.1073/pnas.2102178118 PMID:34819362 PMCID:PMC8640941
- Frankowski, K. J., Brust, T., Lovell, K. M., Yoo, E., Bohn, L. M., Aube, J. Structure-activity relationship investigation of triazole-based kappa opioid receptor agonists Medicinal Chemistry Research 2021 DOI:10.1007/s00044-021-02746-1
- Pantouli, F., Grim, T. W., Schmid, C. L., Acevedo-Canabal, A., Kennedy, N. M., Cameron, M. D., Bannister, T. D., Bohn, L. M. Comparison of morphine, oxycodone and the biased MOR agonist SR-17018 for tolerance and efficacy in mouse models of pain Neuropharmacology 2020 185 DOI:10.1016/j.neuropharm.2020.108439 PMID:33345829 PMCID:PMC7887086
- Hua, T., Li, X., Wu, L., Iliopoulos-Tsoutsouvas, C., Wang, Y., Wu, M., Shen, L., Johnston, C. A., Nikas, S. P., Song, F., Song, X., Yuan, S., et al. Activation and signaling mechanism revealed by cannabinoid receptor-G(i) complex structures Cell 2020 180:655-665 DOI:10.1016/j.cell.2020.01.008 PMID:32004463
- Grim, T. W., Schmid, C. L., Stahl, E. L., Pantouli, F., Ho, J. H., Acevedo-Canabal, A., Kennedy, N. M., Cameron, M. D., Bannister, T. D., Bohn, L. M. A G protein signaling-biased agonist at the μ-opioid receptor reverses morphine tolerance while preventing morphine withdrawal Neuropsychopharmacology 2020 45:416-425 DOI:10.1038/s41386-019-0491-8 PMID:31443104
- Grim, T. W., Acevedo-Canabal, A., Bohn, L. M. Toward directing opioid receptor signaling to refine opioid therapeutics Biological Psychiatry 2020 87:15-21 DOI:10.1016/j.biopsych.2019.10.020 PMID:31806082
- Laprairie, R. B., Vemuri, K., Stahl, E. L., Korde, A., Ho, J. H., Grim, T. W., Hua, T., Wu, Y., Stevens, R. C., Liu, Z. J., Makriyannis, A., Bohn, L. M. Probing the CB1 Cannabinoid Receptor Binding Pocket with AM6538, a High-Affinity Irreversible Antagonist Molecular Pharmacology 2019 96:619-628 DOI:10.1124/mol.119.116483
- Li, X., Hua, T., Vemuri, K., Ho, J. H., Wu, Y., Wu, L., Popov, P., Benchama, O., Zvonok, N., Locke, K., Qu, L., Han, G. W., et al. Crystal structure of the human cannabinoid receptor CB2 Cell 2019 176:459-467 DOI:10.1016/j.cell.2018.12.011 PMID:30639103
- Kennedy, N. M., Schmid, C. L., Ross, N. C., Lovell, K. M., Yue, Z., Chen, Y. T., Cameron, M. D., Bohn, L. M., Bannister, T. D. Optimization of a series of mu opioid receptor (MOR) agonists with high G protein signaling bias Journal of Medicinal Chemistry 2018 61:8895-8907 DOI:10.1021/acs.jmedchem.8b01136 PMID:30199635
- Tosh, D. K., Ciancetta, A., Mannes, P., Warnick, E., Janowsky, A., Eshleman, A. J., Gizewski, E., Brust, T. F., Bohn, L. M., Auchampach, J. A., Gao, Z. G., Jacobson, K. A. Repurposing of a nucleoside scaffold from adenosine receptor agonists to opioid receptor Antagonists ACS Omega 2018 3:12658-12678 DOI:10.1021/acsomega.8b01237 PMID:30411015 PMCID:PMC6210068
- Grim, T. W., Park, S. J., Schmid, C. L., Laprairie, R. B., Cameron, M., Bohn, L. M. The effect of quinine in two bottle choice procedures in C57BL6 mice: Opioid preference, somatic withdrawal, and pharmacokinetic outcomes Drug and Alcohol Dependence 2018 191:195-202 DOI:10.1016/j.drugalcdep.2018.05.034 PMID:30138791
- Hirasawa, S., Cho, M., Brust, T. F., Roach, J. J., Bohn, L. M., Shenvi, R. A. O6C-20-nor-salvinorin A is a stable and potent KOR agonist Bioorganic & Medicinal Chemistry Letters 2018 28:2770-2772 DOI:10.1016/j.bmcl.2018.01.055 PMID:29426768 PMCID:PMC6067998
- Donthamsetti, P., Gallo, E. F., Buck, D. C., Stahl, E. L., Zhu, Y., Lane, J. R., Bohn, L. M., Neve, K. A., Kellendonk, C., Javitch, J. A. Arrestin recruitment to dopamine D2 receptor mediates locomotion but not incentive motivation Molecular Psychiatry 2018 25:2086-2100 DOI:10.1038/s41380-018-0212-4 PMID:30120413 PMCID:PMC6378141
- Ho, J. H., Stahl, E. L., Schmid, C. L., Scarry, S. M., Aube, J., Bohn, L. M. G protein signaling-biased agonism at the κ-opioid receptor is maintained in striatal neurons Science Signaling 2018 11 DOI:10.1126/scisignal.aar4309 PMID:30087177
- Roach, J. J., Sasano, Y., Schmid, C. L., Zaidi, S., Katritch, V., Stevens, R. C., Bohn, L. M., Shenvi, R. A. Dynamic strategic bond analysis yields a ten-step synthesis of 20-nor-salvinorin A, a potent κ-OR agonist ACS Central Science 2017 3:1329-1336 DOI:10.1021/acscentsci.7b00488 PMID:29296674 PMCID:PMC5746855
- Schmid, C. L., Kennedy, N. M., Ross, N. C., Lovell, K. M., Yue, Z., Morgenweck, J., Cameron, M. D., Bannister, T. D., Bohn, L. M. Bias factor and therapeutic window correlate to predict safer opioid analgesics Cell 2017 171:1165-1175 DOI:10.1016/j.cell.2017.10.035 PMID:29149605
- Hua, T., Vemuri, K., Nikas, S. P., Laprairie, R. B., Wu, Y., Qu, L., Pu, M., Korde, A., Jiang, S., Ho, J. H., Han, G. W., Ding, K., et al. Crystal structures of agonist-bound human cannabinoid receptor CB1 Nature 2017 547:468-471 DOI:10.1038/nature23272 PMID:28678776
- Bohn, L. M., Aube, J. Seeking (and finding) biased ligands of the kappa opioid receptor ACS Medicinal Chemistry Letters 2017 8:694-700 DOI:10.1021/acsmedchemlett.7b00224 PMID:28740600 PMCID:PMC5512133
- Mason, J. W., Schmid, C. L., Bohn, L. M., Roush, W. R. Stolonidiol: Synthesis, target identification, and mechanism for choline acetyltransferase activation Journal of the American Chemical Society 2017 139:5865-5869 DOI:10.1021/jacs.7b01083 PMID:28414442
- Laprairie, R. B., Stahl, E. L., Bohn, L. M. Approaches to assess biased signaling at the CB1R receptor Methods in Enzymology 2017 593:259-279 DOI:10.1016/bs.mie.2017.06.031 PMID:28750807
- Brust, T. F., Morgenweck, J., Kim, S. A., Rose, J. H., Locke, J. L., Schmid, C. L., Zhou, L., Stahl, E. L., Cameron, M. D., Scarry, S. M., Aube, J., Jone, S. R., et al. Biased agonists of the kappa opioid receptor suppress pain and itch without causing sedation or dysphoria Science Signaling 2016 9 DOI:10.1126/scisignal.aai8441 PMID:27899527
- Shahani, N., Swarnkar, S., Giovinazzo, V., Morgenweck, J., Bohn, L. M., Scharager-Tapia, C., Pascal, B., Martinez-Acedo, P., Khare, K., Subramaniam, S. RasGRP1 promotes amphetamine-induced motor behavior through a Rhes interaction network ("Rhesactome") in the striatum Science Signaling 2016 9 DOI:10.1126/scisignal.aaf6670 PMID:27902448 PMCID:PMC5142824
- Scarry, S. M., Lovell, K. M., Frankowski, K. J., Bohn, L. M., Aube, J. Synthesis of kappa opioid antagonists based on pyrrolo[1,2-α]quinoxalinones using an N-arylation/condensation/oxidation reaction sequence Journal of Organic Chemistry 2016 81:10538-10550 DOI:10.1021/acs.joc.6b01350 PMID:27399050
- Hua, T., Vemuri, K., Pu, M., Qu, L., Han, G. W., Wu, Y., Zhao, S., Shui, W., Li, S., Korde, A., Laprairie, R. B., Stahl, E. L., et al. Crystal structure of the human cannabinoid receptor CB1 Cell 2016 167:750-762 DOI:10.1016/j.cell.2016.10.004 PMID:27768894
- Rodrigues, P. R., Kaul, T. K., Ho, J. H., Lucanic, M., Burkewitz, K., Mair, W. B., Held, J. M., Bohn, L. M., Gill, M. S. Synthetic ligands of cannabinoid receptors affect dauer formation in the nematode Caenorhabditis elegans G3-Genes Genomes Genetics 2016 6:1695-1705 DOI:10.1534/g3.116.026997 PMID:27172180 PMCID:PMC4889665
- You, I. J., Wright, S. R., Garcia-Garcia, A. L., Tapper, A. R., Gardner, P. D., Koob, G. F., Leonardo, E. D., Bohn, L. M., Wee, S. 5-HT1A autoreceptors in the dorsal raphe nucleus convey vulnerability to compulsive cocaine seeking Neuropsychopharmacology 2016 41:1210-1222 DOI:10.1038/npp.2015.268 PMID:26324408 PMCID:PMC4793105
- Ho, J. H., Lovell, K., Zhou, L., Frankowski, K., Aube, J., Bohn, L. M. Characterization of novel biased KOR agonist-mediated cell signaling FASEB Journal 2016 30
- Rankovic, Z., Brust, T. F., Bohn, L. M. Biased agonism: An emerging paradigm in GPCR drug discovery Bioorganic & Medicinal Chemistry Letters 2016 26:241-250 DOI:10.1016/j.bmcl.2015.12.024 PMID:26707396
- Green, J. A., Schmid, C. L., Bley, E., Monsma, P. C., Brown, A., Bohn, L. M., Mykytyn, K. Recruitment of β-arrestin into neuronal cilia modulates somatostatin receptor subtype 3 ciliary localization Molecular and Cellular Biology 2016 36:223-235 DOI:10.1128/mcb.00765-15 PMID:26503786
- Zhou, L., Stahl, E. L., Lovell, K. M., Frankowski, K. J., Prisinzano, T. E., Aube, J., Bohn, L. M. Characterization of kappa opioid receptor mediated, dynorphin-stimulated [(35)S]GTPγS binding in mouse striatum for the evaluation of selective KOR ligands in an endogenous setting Neuropharmacology 2015 99:131-141 DOI:10.1016/j.neuropharm.2015.07.001 PMID:26160155 PMCID:PMC4655192
- Morgenweck, J., Frankowski, K. J., Prisinzano, T. E., Aube, J., Bohn, L. M. Investigation of the role of βarrestin2 in kappa opioid receptor modulation in a mouse model of pruritus Neuropharmacology 2015 99:600-609 DOI:10.1016/j.neuropharm.2015.08.027 PMID:26318102 PMCID:PMC4739521
- Bohn, L. M., Lohse, M. J., Nitabach, M. N., Taghert, P. H., Smit, M. J. Exploring the biology of G protein-coupled receptors from in vitro to in vivo Molecular Pharmacology 2015 88:534-535 DOI:10.1124/mol.115.100750 PMID:26162863
- Luttrell, L. M., Maudsley, S., Bohn, L. M. Fulfilling the promise of "biased" G protein-coupled receptor agonism Molecular Pharmacology 2015 88:579-588 DOI:10.1124/mol.115.099630 PMID:26134495 PMCID:PMC4551052
- Janero, D. R., Yaddanapudi, S., Zvonok, N., Subramanian, K. V., Shukla, V. G., Stahl, E., Zhou, L., Hurst, D., Wager-Miler, J., Bohn, L. M., Reggio, P. H., Mackie, K., et al. Molecular-interaction and signaling profiles of AM3677, a novel covalent agonist selective for the cannabinoid 1 receptor ACS Chemical Neuroscience 2015 6:1400-1410 DOI:10.1021/acschemneuro.5b00090 PMID:25978068 PMCID:PMC4804703
- Lovell, K. M., Frankowski, K. J., Stahl, E. L., Slauson, S. R., Yoo, E., Prisinzano, T. E., Aubé, J., Bohn, L. M. Structure-activity relationship studies of functionally selective kappa opioid receptor agonists that modulate ERK 1/2 phosphorylation while preserving G protein over βarrestin2 signaling bias ACS Chemical Neuroscience 2015 6:1411-1419 DOI:10.1021/acschemneuro.5b00092 PMID:25891774 PMCID:PMC4830356
- Frankowski, K. J., Slauson, S. R., Lovell, K. M., Phillips, A. M., Streicher, J. M., Zhou, L., Whipple, D. A., Schoenen, F. J., Prisinzano, T. E., Bohn, L. M., Aube, J. Potency enhancement of the κ-opioid receptor antagonist probe ML140 through sulfonamide constraint utilizing a tetrahydroisoquinoline motif Bioorganic & Medicinal Chemistry 2015 23:3948-3956 DOI:10.1016/j.bmc.2014.12.033 PMID:25593096 PMCID:PMC4468036
- Stahl, E. L., Zhou, L., Ehlert, F. J., Bohn, L. M. A novel method for analyzing extremely biased agonism at G protein-coupled receptors Molecular Pharmacology 2015 87:866-877 DOI:10.1124/mol.114.096503 PMID:25680753 PMCID:PMC4407734
- Bohn, L. M., Zhou, L., Ho, J. H. Approaches to assess functional selectivity in GPCRs: evaluating G protein signaling in an endogenous environment Methods in Molecular Biology 2015 1335:177-189 DOI:10.1007/978-1-4939-2914-6_12 PMID:26260601 PMCID:PMC4804702
- Zhou, L., Bohn, L. M. Functional selectivity of GPCR signaling in animals Current Opinion in Cell Biology 2014 27:102-108 DOI:10.1016/j.ceb.2013.11.010 PMID:24680435 PMCID:PMC4349326
- Raehal, K. M., Bohn, L. M. beta-arrestins: regulatory role and therapeutic potential in opioid and cannabinoid receptor-mediated analgesia Handbook of Experimental Pharmacology 2014 219:427-443 DOI:10.1007/978-3-642-41199-1_22 PMID:24292843 PMCID:PMC4804701
- Zhou, L., Lovell, K. M., Frankowski, K. J., Slauson, S. R., Phillips, A. M., Streicher, J. M., Stahl, E., Schmid, C. L., Hodder, P., Madoux, F., Cameron, M. D., Prisinzano, T. E., et al. Development of functionally selective, small molecule agonists at kappa opioid receptors Journal of Biological Chemistry 2013 288:36703-36716 DOI:10.1074/jbc.M113.504381 PMID:24187130 PMCID:PMC3868780
- Schmid, C. L., Streicher, J. M., Groer, C. E., Munro, T. A., Zhou, L., Bohn, L. M. Functional selectivity of 6'-guanidinonaltrindole (6'-GNTI) at kappa-opioid receptors in striatal neurons Journal of Biological Chemistry 2013 288:22387-22398 DOI:10.1074/jbc.M113.476234 PMID:23775075 PMCID:PMC3829329
- Zhou, H., Chisari, M., Raehal, K. M., Kaltenbronn, K. M., Bohn, L. M., Mennerick, S. J., Blumer, K. J. Girk channel modulation by assembly with allosterically regulated RGS proteins Proceedings of the National Academy of Sciences of the United States of America 2012 109:19977-19982 DOI:10.1073/pnas.1214337109 PMID:23169654 PMCID:PMC3523866
- Nguyen, P. T., Schmid, C. L., Raehal, K. M., Selley, D. E., Bohn, L. M., Sim-Selley, L. J. Beta-arrestin2 regulates cannabinoid CB1 receptor signaling and adaptation in a central nervous system region-dependent manner Biological Psychiatry 2012 71:714-724 DOI:10.1016/j.biopsych.2011.11.027 PMID:22264443 PMCID:PMC3319102
- Lamb, K., Tidgewell, K., Simpson, D. S., Bohn, L. M., Prisinzano, T. E. Antinociceptive effects of herkinorin, a MOP receptor agonist derived from salvinorin A in the formalin test in rats: New concepts in mu opioid receptor pharmacology: From a symposium on new concepts in mu-opioid pharmacology Drug and Alcohol Dependence 2012 121:181-188 DOI:10.1016/j.drugalcdep.2011.10.026 PMID:22119134 PMCID:PMC3288203
- Frankowski, K. J., Hedrick, M. P., Gosalia, P., Li, K. L., Shi, S. H., Whipple, D., Ghosh, P., Prisinzano, T. E., Schoenen, F. J., Su, Y., Vasile, S., Sergienko, E., et al. Discovery of small molecule kappa opioid receptor agonist and antagonist chemotypes through a HTS and Hit refinement strategy ACS Chemical Neuroscience 2012 3:221-236 DOI:10.1021/cn200128x PMID:22737280 PMCID:PMC3378255
- Beguin, C., Potuzak, J., Xu, W., Liu-Chen, L. Y., Streicher, J. M., Groer, C. E., Bohn, L. M., Carlezon, W. A., Cohen, B. M. Differential signaling properties at the kappa opioid receptor of 12-epi-salvinorin A and its analogues Bioorganic & Medicinal Chemistry Letters 2012 22:1023-1026 DOI:10.1016/j.bmcl.2011.11.128 PMID:22204910 PMCID:PMC3926198
- Raehal, K. M., Schmid, C. L., Groer, C. E., Bohn, L. M. Functional selectivity at the mu-opioid receptor: Implications for understanding opioid analgesia and tolerance Pharmacological Reviews 2011 63:1001-1019 DOI:10.1124/pr.111.004598 PMID:21873412 PMCID:PMC3186080
- Groer, C. E., Schmid, C. L., Jaeger, A. M., Bohn, L. M. Agonist-directed interactions with specific beta-arrestins determine mu-opioid receptor trafficking, ubiquitination, and dephosphorylation Journal of Biological Chemistry 2011 286:31731-31741 DOI:10.1074/jbc.M111.248310 PMID:21757712 PMCID:PMC3173119
- Tarselli, M. A., Raehal, K. M., Brasher, A. K., Streicher, J. M., Groer, C. E., Cameron, M. D., Bohn, L. M., Micalizio, G. C. Synthesis of conolidine, a potent non-opioid analgesic for tonic and persistent pain Nature Chemistry 2011 3:449-453 DOI:10.1038/nchem.1050 PMID:21602859
- Sun, X. H., Wang, X. Y., Wang, G. D., Xia, Y., Liu, S. M., Qu, M. H., Needleman, B. J., Mikami, D. J., Melvin, W. S., Bohn, L. M., Ueno, R., Wood, J. D. Lubiprostone reverses the inhibitory action of morphine on mucosal secretion in human small intestine Digestive Diseases and Sciences 2011 56:330-338 DOI:10.1007/s10620-010-1515-8 PMID:21181441 PMCID:PMC4757489
- Bohn, L. M., McDonald, P. H. Detecting the role of arrestins in G protein-coupled receptor regulation Neuromethods 2011 60:347-358 DOI:10.1007/978-1-61779-179-6_17
- Raehal, K. M., Bohn, L. M. The role of beta-arrestin2 in the severity of antinociceptive tolerance and physical dependence induced by different opioid pain therapeutics Neuropharmacology 2011 60:58-65 DOI:10.1016/j.neuropharm.2010.08.003 PMID:20713067 PMCID:PMC2981657
- Bohn, L. M., Schmid, C. L. Serotonin receptor signaling and regulation via beta-arrestins Critical Reviews in Biochemistry and Molecular Biology 2010 45:555-566 DOI:10.3109/10409238.2010.516741 PMID:20925600 PMCID:PMC4776633
- Schmid, C. L., Bohn, L. M. Serotonin, but not N-methyltryptamines, activates the serotonin 2A receptor via a beta-arrestin2/Src/Akt signaling complex in vivo Journal of Neuroscience 2010 30:13513-13524 DOI:10.1523/jneurosci.1665-10.2010 PMID:20926677 PMCID:PMC3001293
- Fei, G. J., Raehal, K., Liu, S. M., Qu, M. H., Sun, X. H., Wang, G. D., Wang, X. Y., Xia, Y., Schmid, C. L., Bohn, L. M., Wood, J. D. Lubiprostone reverses the inhibitory action of morphine on intestinal secretion in guinea pig and mouse Journal of Pharmacology and Experimental Therapeutics 2010 334:333-340 DOI:10.1124/jpet.110.166116 PMID:20406855 PMCID:PMC2912047
- Bohn, L. M., McDonald, P. H. Seeking ligand bias: assessing GPCR coupling to beta-arrestins for drug discovery Drug Discovery Today. Technologies 2010 7:e37-e42 DOI:10.1016/j.ddtec.2010.06.005 PMID:21218149 PMCID:PMC3014586
- Raehal, K. M., Schmid, C. L., Medvedev, I. O., Gainetdinov, R. R., Premont, R. T., Bohn, L. M. Morphine-induced physiological and behavioral responses in mice lacking g protein-coupled receptor kinase 6 Drug and Alcohol Dependence 2009 104:187-196 DOI:10.1016/j.drugalcdep.2009.04.011 PMID:19497686 PMCID:PMC2771341
- Zhang, L., Nothacker, H. P., Wang, Z. W., Bohn, L. M., Civelli, O. Pharmacological characterization of a selective agonist for bombesin receptor subtype-3 Biochemical and Biophysical Research Communications 2009 387:283-288 DOI:10.1016/j.bbrc.2009.07.006 PMID:19580790 PMCID:PMC2747518
- Fei, G. J., Wang, Y. Z., Liu, S. M., Hu, H. Z., Wang, G. D., Qu, M. H., Wang, X. Y., Xia, Y., Sun, X. H., Bohn, L. M., Cooke, H. J., Wood, J. D. Stimulation of mucosal secretion by lubiprostone (SPI-0211) in guinea pig small intestine and colon American Journal of Physiology-Gastrointestinal and Liver Physiology 2009 296:G823-G832 DOI:10.1152/ajpgi.90447.2008 PMID:19179625 PMCID:PMC2670663
- Schmid, C. L., Bohn, L. M. Physiological and pharmacological implications of beta-arrestin regulation Pharmacology & Therapeutics 2009 121:285-293 DOI:10.1016/j.pharmthera.2008.11.005 PMID:19100766 PMCID:PMC2656564
- McLennan, G. P., Kiss, A., Miyatake, M., Belcheva, M. M., Chambers, K. T., Pozek, J. J., Mohabbat, Y., Moyer, R. A., Bohn, L. M., Coscia, C. J. Kappa opioids promote the proliferation of astrocytes via Gbetagamma and beta-arrestin 2-dependent MAPK-mediated pathways Journal of Neurochemistry 2008 107:1753-1765 DOI:10.1111/j.1471-4159.2008.05745.x PMID:19014370 PMCID:PMC2606093
- Tidgewell, K., Groer, C. E., Harding, W. W., Lozama, A., Schmidt, M., Marquam, A., Hiemstra, J., Partilla, J. S., Dersch, C. M., Rothman, R. B., Bohn, L. M., Prisinzano, T. E. Herkinorin analogues with differential beta-arrestin-2 interactions Journal of Medicinal Chemistry 2008 51:2421-2431 DOI:10.1021/jm701162g PMID:18380425 PMCID:PMC2494883
- Gupta, A., Rozenfeld, R., Gomes, I., Raehal, K. M., Decaillot, F. M., Bohn, L. M., Devi, L. A. Post-activation-mediated changes in opioid receptors detected by N-terminal antibodies Journal of Biological Chemistry 2008 283:10735-10744 DOI:10.1074/jbc.M709454200 PMID:18256033 PMCID:PMC2447646
- Schmid, C. L., Raehal, K. M., Bohn, L. M. Agonist-directed signaling of the serotonin 2A receptor depends on beta-arrestin-2 interactions in vivo Proceedings of the National Academy of Sciences of the United States of America 2008 105:1079-1084 DOI:10.1073/pnas.0708862105 PMID:18195357 PMCID:PMC2242710
- Xu, H., Partilla, J. S., Wang, X. Y., Rutherford, J. M., Tidgewell, K., Prisinzano, T. E., Bohn, L. M., Rothman, R. B. A comparison of noninternalizing (herkinorin) and internalizing (DAMGO) mu-opioid agonists on cellular markers related to opioid tolerance and dependence Synapse 2007 61:166-175 DOI:10.1002/syn.20356 PMID:17152090
- Groer, C. E., Tidgewell, K., Moyer, R. A., Harding, W. W., Rothman, R. B., Prisinzano, T. E., Bohn, L. M. An opioid agonist that does not induce mu-opioid receptor - arrestin interactions or receptor internalization Molecular Pharmacology 2007 71:549-557 DOI:10.1124/mol.106.028258 PMID:17090705 PMCID:PMC3926195
- Bohn, L. M., Raehal, K. M. Opioid receptor signaling: relevance for gastrointestinal therapy Current Opinion in Pharmacology 2006 6:559-563 DOI:10.1016/j.coph.2006.06.007 PMID:16935560
- Raehal, K. M., Walker, J. K. L., Bohn, L. M. Morphine side effects in beta-arrestin 2 knockout mice Journal of Pharmacology and Experimental Therapeutics 2005 314:1195-1201 DOI:10.1124/jpet.105.087254 PMID:15917400
- Medvedev, I. O., Gainetdinov, R. R., Sotnikova, T. D., Bohn, L. M., Caron, M. G., Dykstra, L. A. Characterization of conditioned place preference to cocaine in congenic dopamine transporter knockout female mice Psychopharmacology 2005 180:408-413 DOI:10.1007/s00213-005-2173-y PMID:15719221
- Wang, D. X., Sun, X. C., Bohn, L. M., Sadee, W. Opioid receptor homo- and heterodimerization in living cells by quantitative bioluminescence resonance energy transfer Molecular Pharmacology 2005 67:2173-2184 DOI:10.1124/mol.104.010272. PMID:15778451
- Raehal, K. M., Bohn, L. M. Mu opioid receptor regulation and opiate responsiveness AAPS Journal 2005 7:E587-E591 DOI:10.1208/aapsj070360 PMID:16353937 PMCID:PMC2751262
- Bohn, L. M., Dykstra, L. A., Lefkowitz, R. J., Caron, M. G., Barak, L. S. Relative opioid efficacy is determined by the complements of the G protein-coupled receptor desensitization machinery Molecular Pharmacology 2004 66:106-112 DOI:10.1124/mol.66.1.106 PMID:15213301
- Johnson, E. C., Bohn, L. M., Taghert, P. H. Drosophila CG8422 encodes a functional diuretic hormone receptor Journal of Experimental Biology 2004 207:743-748 DOI:10.1242/jeb.00818 PMID:14747406
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news release
- The search for the perfect painkiller The Guardian. 2018
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