recent publications
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academic article
- Angelbello, A. J., Defeo, M. E., Glinkerman, C. M., Boger, D. L., Disney, M. D. Precise Targeted Cleavage of a r(CUG) Repeat Expansion in Cells by Using a Small-Molecule-Deglycobleomycin Conjugate ACS Chemical Biology 2020 15:849-855 DOI:10.1021/acschembio.0c00036 PMCID:32186845
- Wu, Z. C., Isley, N. A., Okano, A., Weiss, W. J., Boger, D. L. C1-CBP-vancomycin: Impact of a vancomycin C-terminus trimethylammonium cation on pharmacological properties and insights into its newly introduced mechanism of action Journal of Organic Chemistry 2020 85:1365-1375 DOI:10.1021/acs.joc.9b02314 PMID:31670958 PMCID:PMC7007832
- Moore, M. J., Qu, S. W., Tan, C. H., Cai, Y., Mogi, Y., Keith, D. J., Boger, D. L. Next-Generation Total Synthesis of Vancomycin Journal of the American Chemical Society 2020 142:16039-16050 DOI:10.1021/jacs.0c07433 PMID:32885969 PMCID:PMC7501256
- Wu, Z. C., Cameron, M. D., Boger, D. L. Vancomycin C-Terminus Guanidine Modifications and Further Insights into an Added Mechanism of Action Imparted by a Peripheral Structural Modification ACS Infectious Diseases 2020 6:2169-2180 DOI:10.1021/acsinfecdis.0c00258 PMID:32598127 PMCID:PMC7429263
- Beekman, A. M., Cominetti, M. M. D., Cartwright, O. C., Boger, D. L., Searcey, M. A small molecule drug conjugate (SMDC) of DUPA and a duocarmycin built on the solid phase MedChemComm 2019 10:2170-2174 DOI:10.1039/c9md00279k
- Plewe, M. B., Whitby, L. R., Naik, S., Brown, E. R., Sokolova, N. V., Gantla, V. R., York, J., Nunberg, J. H., Zhang, L., Kalveram, B., Freiberg, A. N., Boger, D. L., et al. SAR studies of 4-acyl-1,6-dialkylpiperazin-2-one arenavirus cell entry inhibitors Bioorganic & Medicinal Chemistry Letters 2019 29 DOI:10.1016/j.bmcl.2019.08.024 PMID:31537423 PMCID:PMC6803051
- Isley, N. A., Endo, Y., Wu, Z. C., Covington, B. C., Bushin, L. B., Seyedsayamdost, M. R., Boger, D. L. Total synthesis and stereochemical assignment of streptide Journal of the American Chemical Society 2019 141:17361-17369 DOI:10.1021/jacs.9b09067 PMID:31577142 PMCID:PMC6821584
- Ozog, S., Timberlake, N. D., Hermann, K., Garijo, O., Haworth, K. G., Shi, G., Glinkerman, C. M., Schefter, L. E., D'Souza, S., Simpson, E., Sghia-Hughes, G., Carillo, R. R., et al. Resveratrol trimer enhances gene delivery to hematopoietic stem cells by reducing antiviral restriction at endosomes Blood 2019 134:1298-1311 DOI:10.1182/blood.2019000040 PMID:31416800
- Boon, B. A., Boger, D. L. Triarylaminium radical cation promoted coupling of catharanthine with vindoline: diastereospecific synthesis of anhydrovinblastine and reaction scope Journal of the American Chemical Society 2019 141:14349-14355 DOI:10.1021/jacs.9b06968 PMID:31442047 PMCID:PMC6750708
- Wu, Z. C., Boger, D. L. Exploration of the site-specific nature and generalizability of a trimethylammonium salt modification on vancomycin: A-ring derivatives Tetrahedron 2019 75:3160-3165 DOI:10.1016/j.tet.2019.02.008
- Radakovic, A., Boger, D. L. Ultra-potent vinblastine analogues improve on-target activity of the parent microtubulin-targeting compound Bioorganic & Medicinal Chemistry Letters 2019 29:1370-1374 DOI:10.1016/j.bmcl.2019.03.036 PMID:30952593 PMCID:PMC6487230
- Otrubova, K., Chatterjee, S., Ghimire, S., Cravatt, B. F., Boger, D. L. N-acyl pyrazoles: effective and tunable inhibitors of serine hydrolases Bioorganic & Medicinal Chemistry 2019 27:1693-1703 DOI:10.1016/j.bmc.2019.03.020 PMID:30879861
- Su, L., Wang, Y., Wang, J., Mifune, Y., Morin, M. D., Jones, B. T., Moresco, E. M. Y., Boger, D. L., Beutler, B., Zhang, H. Structural basis of TLR2/TLR1 activation by the synthetic agonist diprovocim Journal of Medicinal Chemistry 2019 62:2938-2949 DOI:10.1021/acs.jmedchem.8b01583 PMID:30829478
- Zhang, J., Shukla, V., Boger, D. L. Inverse electron demand Diels-Alder reactions of heterocyclic azadienes, 1-aza-1,3-butadienes, cyclopropenone ketals and related systems. A retrospective Journal of Organic Chemistry 2019 DOI:10.1021/acs.joc.9b00834
- Morin, M. D., Wang, Y., Jones, B. T., Mifune, Y., Su, L., Shi, H., Moresco, E. M. Y., Zhang, H., Beutler, B., Boger, D. L. Diprovocims: A new and exceptionally potent class of toll-like receptor agonists Journal of the American Chemical Society 2018 140:14440-14454 DOI:10.1021/jacs.8b09223 PMID:30272974 PMCID:PMC6209530
- Wu, Z. C., Isley, N. A., Boger, D. L. N-terminus alkylation of vancomycin: ligand binding affinity, antimicrobial activity, and site-specific nature of quaternary trimethylammonium salt modification ACS Infectious Diseases 2018 4:1468-1474 DOI:10.1021/acsinfecdis.8b00152 PMID:30067012 PMCID:PMC6200594
- Wang, Y., Su, L., Morin, M. D., Jones, B. T., Mifune, Y., Shi, H., Wang, K., Zhan, X., Liu, A., Wang, J., Li, X., Tang, M., et al. Adjuvant effect of the novel TLR1/TLR2 agonist Diprovocim synergizes with anti-PD-L1 to eliminate melanoma in mice Proceedings of the National Academy of Sciences of the United States of America 2018 115:E8698-E8706 DOI:10.1073/pnas.1809232115 PMID:30150374 PMCID:PMC6140543
- Boyle, K. E., Boger, D. L., Wroe, A., Vazquez, M. Duocarmycin SA, a potent antitumor antibiotic, sensitizes glioblastoma cells to proton radiation Bioorganic & Medicinal Chemistry Letters 2018 28:2688-2692 DOI:10.1016/j.bmcl.2018.04.008 PMID:29650288
- Glinkerman, C. M., Boger, D. L. Synthesis, characterization, and rapid cycloadditions of 5-nitro-1,2,3-triazine Organic Letters 2018 20:2628-2631 DOI:10.1021/acs.orglett.8b00825 PMID:29659291 PMCID:PMC5935562
- Radakovic, A., Boger, D. L. High expression of class III β-tubulin has no impact on functional cancer cell growth inhibition of a series of key vinblastine analogs Bioorganic & Medicinal Chemistry Letters 2018 28:863-865 DOI:10.1016/j.bmcl.2018.02.006 PMID:29439899 PMCID:PMC5835219
- Boger, D. L. The difference a single atom can make: synthesis and design at the chemistry-biology interface Journal of Organic Chemistry 2017 82:11961-11980 DOI:10.1021/acs.joc.7b02088 PMID:28945374 PMCID:PMC5712263
- Okano, A., Isley, N. A., Boger, D. L. Total syntheses of vancomycin-related glycopeptide antibiotics and key analogues Chemical Reviews 2017 117:11952-11993 DOI:10.1021/acs.chemrev.6b00820 PMID:28437097 PMCID:PMC5617763
- Quinones, R. E., Glinkerman, C. M., Zhu, K., Boger, D. L. Direct synthesis of β-aminoenals through reaction of 1,2,3-triazine with secondary amines Organic Letters 2017 19:3568-3571 DOI:10.1021/acs.orglett.7b01543 PMID:28657329
- Okano, A., Isley, N. A., Boger, D. L. Peripheral modifications of [Ψ[CH2NH]Tpg4]vancomycin with added synergistic mechanisms of action provide durable and potent antibiotics Proceedings of the National Academy of Sciences of the United States of America 2017 114:E5052-E5061 DOI:10.1073/pnas.1704125114 PMID:28559345 PMCID:PMC5495262
- Kornahrens, A. F., Cognetta III, A. B., Brody, D. M., Matthews, M. L., Cravatt, B. F., Boger, D. L. Design of benzoxathiazin-3-one 1,1-dioxides as a new class of irreversible serine hydrolase inhibitors: Discovery of a uniquely selective PNPLA4 inhibitor Journal of the American Chemical Society 2017 139:7052-7061 DOI:10.1021/jacs.7602985 PMID:28498651
- Yang, S., Sankar, K., Skepper, C. K., Barker, T. J., Lukesh, J. C., Brody, D. M., Brutsch, M. M., Boger, D. L. Total synthesis of a key series of vinblastines modified at C4 that define the importance and surprising trends in activity Chemical Science 2017 8:1560-1569 DOI:10.1039/c6sc04146a PMID:28194270 PMCID:PMC5302862
- Lukesh III, J. C., Carney, D. W., Dong, H. J., Cross, R. M., Shukla, V., Duncan, K. K., Yang, S. L., Brody, D. M., Brutsch, M. M., Radakovic, A., Boger, D. L. Vinblastine 20 ' amides: synthetic analogues that maintain or improve potency and simultaneously overcome Pgp-derived efflux and resistance Journal of Medicinal Chemistry 2017 60:7591-7604 DOI:10.1021/acs.jmedchem.7b00958 PMID:28857558 PMCID:PMC5599373
- Chanda, P. B., Boyle, K. E., Brody, D. A., Shukla, V., Boger, D. L. Synthesis and evaluation of duocarmycin SA analogs incorporating the methyl 1,2,8,8a-tetrahydrocyclopropa c imidazolo 4,5-e indol-4-one-6-carboxylat e (CImI) alkylation subunit Bioorganic & Medicinal Chemistry 2016 24:4779-4786 DOI:10.1016/j.bmc.2016.04.050 PMID:27221071 PMCID:PMC5052114
- Glinkerman, C. M., Boger, D. L. Catalysis of heterocyclic azadiene cycloaddition reactions by solvent hydrogen bonding: concise total synthesis of methoxatin Journal of the American Chemical Society 2016 138:12408-12413 DOI:10.1021/jacs.6b05438 PMID:27571404 PMCID:PMC5042865
- Carney, D. W., Lukesh III, J. C., Brody, D. M., Brutsch, M. M., Boger, D. L. Ultrapotent vinblastines in which added molecular complexity further disrupts the target tubulin dimer-dimer interface Proceedings of the National Academy of Sciences of the United States of America 2016 113:9691-9698 DOI:10.1073/pnas.1611405113 PMID:27512044 PMCID:PMC5024590
- Shankar, S., Whitby, L. R., Casquilho-Gray, H. E., York, J., Boger, D. L., Nunberg, J. H. Small-molecule fusion inhibitors bind the pH-sensing stable signal peptide-GP2 subunit interface of the Lassa virus Envelope glycoprotein Journal of Virology 2016 90:6799-6807 DOI:10.1128/jvi.00597-16 PMID:27194767 PMCID:PMC4944282
- Burman, M. A., Szolusha, K., Bind, R., Kerney, K., Boger, D. L., Bilsky, E. J. FAAH inhibitor OL-135 disrupts contextual, but not auditory, fear conditioning in rats Behavioural Brain Research 2016 308:1-5 DOI:10.1016/j.bbr.2016.04.014 PMID:27083303 PMCID:PMC4877211
- Allemann, O., Brutsch, M., Lukesh III, J. C., Brody, D. M., Boger, D. L. Synthesis of a potent vinblastine: rationally designed added benign complexity Journal of the American Chemical Society 2016 138:8376-8379 DOI:10.1021/jacs.6b04330 PMID:27356080 PMCID:PMC4945418
- Morin, M. D., Wang, Y., Jones, B. T., Su, L., Surakattula, M. M. R. P., Berger, M., Huang, H., Beutler, E. K., Zhang, H., Beutler, B., Boger, D. L. Discovery and structure-activity relationships of the neoseptins: a new class of toll-like receptor-4 (TLR4) agonists Journal of Medicinal Chemistry 2016 59:4812-4830 DOI:10.1021/acs.jmedchem.6b00177 PMID:27050713 PMCID:PMC4882283
- Sears, J. E., Boger, D. L. Tandem intramolecular Diels-Alder/1,3-dipolar cycloaddition cascade of 1,3,4-oxadiazoles: initial scope and applications Accounts of Chemical Research 2016 49:241-251 DOI:10.1021/acs.accounts.5b00510 PMID:26813287 PMCID:PMC4755904
- Wang, Y., Su, L., Morin, M. D., Jones, B. T., Whitby, L. R., Surakattula, M. M. R. P., Huang, H., Shi, H., Choi, J. H., Wang, K. W., Moresco, E. M. Y., Berger, M., et al. TLR4/MD-2 activation by a synthetic agonist with no similarity to LPS Proceedings of the National Academy of Sciences of the United States of America 2016 113:E884-E893 DOI:10.1073/pnas.1525639113 PMID:26831104 PMCID:PMC4763747
- Janssen, F. J., Baggelaar, M. P., Hummel, J. J. A., Overkleeft, H. S., Cravatt, B. F., Boger, D. L., van der Stelt, M. Comprehensive analysis of structure-activity relationships of a-ketoheterocycles as sn-1-diacylglycerol lipase a inhibitors Journal of Medicinal Chemistry 2015 58:9742-9753 DOI:10.1021/acs.jmedchem.5b01627 PMID:26584396 PMCID:PMC4690813
- Sears, J. E., Barker, T. J., Boger, D. L. Total synthesis of (-)-vindoline and (+)-4-epi-vindoline based on a 1,3,4-oxadiazole tandem intramolecular 4+2 / 3+2 cycloaddition cascade initiated by an allene dienophile Organic Letters 2015 17:5460-5463 DOI:10.1021/acs.orglett.5b02818 PMID:26457536 PMCID:PMC4636949
- Boger, D. L. When sugar is not so sweet Science 2015 350:275-276 DOI:10.1126/science.aad3298
- Lee, K., Poudel, Y. B., Glinkerman, C. M., Boger, D. L. Total synthesis of dihydrolysergic acid and dihydrolysergol: development of a divergent synthetic strategy applicable to rapid assembly of D-ring analogs Tetrahedron 2015 71:5897-5905 DOI:10.1016/j.tet.2015.05.093 PMID:26273113 PMCID:PMC4528678
- Glinkerman, C. M., Boger, D. L. Cycloadditions of 1,2,3-triazines bearing C5-electron donating substituents: robust pyrimidine synthesis Organic Letters 2015 17:4002-4005 DOI:10.1021/acs.orglett.5b01870 PMID:26172042 PMCID:PMC4546508
- Uematsu, M., Brody, D. M., Boger, D. L. A five-membered lactone prodrug of CBI-based analogs of the duocarmycins Tetrahedron Letters 2015 56:3101-3104 DOI:10.1016/j.tetlet.2014.11.038 PMID:26069351 PMCID:PMC4459655
- Lee, K., Boger, D. L. Total synthesis of (-)-kopsinine and ent-(+)-kopsinine Tetrahedron 2015 71:3741-3746 DOI:10.1016/j.tet.2014.07.094 PMID:26074629 PMCID:PMC4461145
- Okano, A., Nakayama, A., Wu, K., Lindsey, E. A., Schammel, A. W., Feng, Y., Collins, K. C., Boger, D. L. Total syntheses and initial evaluation of [?[C(-S)NH]Tpg(4)]vancomycin, [?[C(-NH)NH]Tpg(4)]vancomycin, [?[CH2NH]Tpg(4)]vancomycin, and their (4-Chlorobiphenyl)methyl derivatives: synergistic binding pocket and peripheral modifications for the glycopeptide antibiotics Journal of the American Chemical Society 2015 137:3693-3704 DOI:10.1021/jacs.5b01008 PMID:25750995 PMCID:PMC4376669
- Sears, J. E., Boger, D. L. Total synthesis of vinblastine, related natural products, and key analogues and development of inspired methodology suitable for the systematic study of their structure-function properties Accounts of Chemical Research 2015 48:653-662 DOI:10.1021/ar500400w PMID:25586069 PMCID:PMC4363169
- Zhao, N., Darby, C. M., Small, J., Bachovchin, D. A., Jiang, X., Burns-Huang, K. E., Botella, H., Ehrt, S., Boger, D. L., Anderson, E. D., Cravatt, B. F., Speers, A. E., et al. Target-based screen against a periplasmic serine protease that regulates intrabacterial pH homeostasis in Mycobacterium tuberculosis ACS Chemical Biology 2015 10:364-371 DOI:10.1021/cb500746z PMID:25457457 PMCID:PMC4340348
- Uematsu, M., Boger, D. L. Asymmetric synthesis of a CBI-based cyclic N-acyl O-amino phenol duocarmycin prodrug Journal of Organic Chemistry 2014 79:9699-9703 DOI:10.1021/jo501839x PMID:25247380 PMCID:PMC4201355
- Anderson, E. D., Duerfeldt, A. S., Zhu, K., Glinkerman, C. M., Boger, D. L. Cycloadditions of noncomplementary substituted 1,2,3-triazines Organic Letters 2014 16:5084-5087 DOI:10.1021/ol502436n PMID:25222918 PMCID:PMC4184932
- Okano, A., Nakayama, A., Schammel, A. W., Boger, D. L. Total synthesis of Psi C(=NH)NH Tpg(4) vancomycin and its ((4)-chlorobiphenyl)methyl derivative: impact of peripheral modifications on vancomycin analogues redesigned for dual D-Ala-D-Ala and D-Ala-D-Lac binding Journal of the American Chemical Society 2014 136:13522-13525 DOI:10.1021/ja507009a PMID:25211770 PMCID:PMC4183650
- Otrubova, K., Srinivasan, V., Boger, D. L. Discovery libraries targeting the major enzyme classes: the serine hydrolases Bioorganic & Medicinal Chemistry Letters 2014 24:3807-3813 DOI:10.1016/j.bmcl.2014.06.063 PMID:25037918 PMCID:PMC4130767
- Sanchez-Cespedes, J., Moyer, C. L., Whitby, L. R., Boger, D. L., Nemerow, G. R. Inhibition of adenovirus replication by a trisubstituted piperazin-2-one derivative Antiviral Research 2014 108:65-73 DOI:10.1016/j.antiviral.2014.05.010 PMID:24907427 PMCID:PMC4101041
- Nakayama, A., Okano, A., Feng, Y. Q., Collins, J. C., Collins, K. C., Walsh, C. T., Boger, D. L. Enzymatic glycosylation of vancomycin aglycon: completion of a total synthesis of vancomycin and N- and C-terminus substituent effects of the aglycon substrate Organic Letters 2014 16:3572-3575 DOI:10.1021/ol501568t PMID:24954524 PMCID:PMC4084835
- Duncan, K. K., Otrubova, K., Boger, D. L. alpha-Ketoheterocycle inhibitors of fatty acid amide hydrolase: exploration of conformational constraints in the acyl side chain Bioorganic & Medicinal Chemistry 2014 22:2763-2770 DOI:10.1016/j.bmc.2014.03.013 PMID:24690529 PMCID:PMC4029506
- Lee, K., Boger, D. L. Total syntheses of (-)-kopsifoline D and (-)-deoxoapodine: divergent total synthesis via late-stage key strategic bond formation Journal of the American Chemical Society 2014 136:3312-3317 DOI:10.1021/ja500548e PMID:24499015 PMCID:PMC3985950
- Dreyton, C. J., Anderson, E. D., Subramanian, V., Boger, D. L., Thompson, P. R. Insights into the mechanism of streptonigrin-induced protein arginine deiminase inactivation Bioorganic & Medicinal Chemistry 2014 22:1362-1369 DOI:10.1016/j.bmc.2013.12.064 PMID:24440480 PMCID:PMC3954981
- Otrubova, K., Cravatt, B. F., Boger, D. L. Design, synthesis, and characterization of alpha-ketoheterocycles that additionally target the cytosolic port Cys269 of fatty acid amide hydrolase Journal of Medicinal Chemistry 2014 57:1079-1089 DOI:10.1021/jm401820q PMID:24456116 PMCID:PMC3940414
- Duerfeldt, A. S., Boger, D. L. Total syntheses of (-)-pyrimidoblamic acid and P-3A Journal of the American Chemical Society 2014 136:2119-2125 DOI:10.1021/ja412298c PMID:24410439 PMCID:PMC3940392
- Campbell, E. L., Skepper, C. K., Sankar, K., Duncan, K. K., Boger, D. L. Transannular Diels-Alder/1,3-dipolar cycloaddition cascade of 1,3,4-oxadiazoles: total synthesis of a unique set of vinblastine analogues Organic Letters 2013 15:5306-5309 DOI:10.1021/oI402549n PMID:24087969
- Barker, T. J., Duncan, K. K., Otrubova, K., Boger, D. L. Potent vinblastine C20' ureas displaying additionally improved activity against a vinblastine-resistant cancer cell line ACS Medicinal Chemistry Letters 2013 4:985-988 DOI:10.1021/ml400281w PMID:24223237 PMCID:PMC3821838
- Wolfe, A. L., Duncan, K. K., Lajiness, J. P., Zhu, K. C., Duerfeldt, A. S., Boger, D. L. A fundamental relationship between hydrophobic properties and biological activity for the duocarmycin class of DNA-alkylating antitumor drugs: hydrophobic-binding-driven bonding Journal of Medicinal Chemistry 2013 56:6845-6857 DOI:10.1021/jm400665c PMID:23944748 PMCID:PMC3793852
- Pinchman, J. R., Boger, D. L. Investigation into the functional impact of the vancomycin C-ring aryl chloride Bioorganic & Medicinal Chemistry Letters 2013 23:4817-4819 DOI:10.1016/j.bmcl.2013.06.080 PMID:23880541 PMCID:PMC3757926
- Connelly, S., DeMartino, J. K., Boger, D. L., Wilson, I. A. Biological and structural evaluation of 10R- and 10S-methylthio-DDACTHF reveals a new role for sulfur in inhibition of glycinamide ribonucleotide transformylase Biochemistry 2013 52:5133-5144 DOI:10.1021/bi4005182 PMID:23869564 PMCID:PMC3823235
- Gochin, M., Whitby, L. R., Phillips, A. H., Boger, D. L. NMR-assisted computational studies of peptidomimetic inhibitors bound in the hydrophobic pocket of HIV-1 glycoprotein 41 Journal of Computer-Aided Molecular Design 2013 27:569-582 DOI:10.1007/s10822-013-9662-6 PMID:23893342 PMCID:PMC3777804
- Vielhauer, G. A., Swink, M., Parelkar, N. K., Lajiness, J. P., Wolfe, A. L., Boger, D. Evaluation of a reductively activated duocarmycin prodrug against murine and human solid cancers Cancer Biology & Therapy 2013 14:527-536 DOI:10.4161/cbt.24348 PMID:23760495 PMCID:PMC3813569
- Wolfe, A. L., Duncan, K. K., Parelkar, N. K., Brown, D., Vielhauer, G. A., Boger, D. L. Efficacious cyclic N-acyl O-amino phenol duocarmycin prodrugs Journal of Medicinal Chemistry 2013 56:4104-4115 DOI:10.1021/jm400413r PMID:23627265 PMCID:PMC3687800
- Pinchman, J. R., Boger, D. L. Probing the role of the vancomycin E-ring aryl chloride: selective divergent synthesis and evaluation of alternatively substituted E-ring analogues Journal of Medicinal Chemistry 2013 56:4116-4124 DOI:10.1021/jm4004494 PMID:23617725 PMCID:PMC3667592
- Otrubova, K., Brown, M., McCormick, M. S., Han, G. W., O'Neal, S. T., Cravatt, B. F., Stevens, R. C., Lichtman, A. H., Boger, D. L. Rational design of fatty acid amide hydrolase inhibitors that act by covalently bonding to two active site residues Journal of the American Chemical Society 2013 135:6289-6299 DOI:10.1021/ja4014997 PMID:23581831 PMCID:PMC3678763
- Turner, T. C., Shibayama, K., Boger, D. L. Hypervalent iodine(III)-promoted intermolecular C-C coupling of vindoline with β-ketoesters and related substrates Organic Letters 2013 15:1100-1103 DOI:10.1021/ol400135n PMID:23421318 PMCID:PMC3607625
- Xie, J., Wolfe, A. L., Boger, D. L. Total synthesis of kopsinine Organic Letters 2013 15:868-870 DOI:10.1021/ol303573f PMID:23391149 PMCID:PMC3578506
- Leggans, E. K., Duncan, K. K., Barker, T. J., Schleicher, K. D., Boger, D. L. A remarkable series of vinblastine analogues displaying enhanced activity and an unprecedented tubulin binding steric tolerance: C20' urea derivatives Journal of Medicinal Chemistry 2013 56:628-639 DOI:10.1021/jm3015684 PMID:23244701 PMCID:PMC3574233
- Breazzano, S. P., Poudel, Y. B., Boger, D. L. A Pd(0)-mediated indole (macro)cyclization reaction Journal of the American Chemical Society 2013 135:1600-1606 DOI:10.1021/ja3121394 PMID:23298368 PMCID:PMC3560319
- Schleicher, K. D., Sasaki, Y., Tam, A., Kato, D., Duncan, K. K., Boger, D. L. Total synthesis and evaluation of vinblastine analogues containing systematic deep-seated modifications in the vindoline subunit ring system: Core redesign Journal of Medicinal Chemistry 2013 56:483-495 DOI:10.1021/jm3014376 PMID:23252481 PMCID:PMC3554876
- Whitby, L. R., Boger, D. L. Comprehensive peptidomimetic libraries targeting protein-protein interactions Accounts of Chemical Research 2012 45:1698-1709 DOI:10.1021/ar300025n PMID:22799570 PMCID:PMC3473115
- Barker, T. J., Boger, D. L. Fe(III)/NaBH4-mediated free radical hydrofluorination of unactivated alkenes Journal of the American Chemical Society 2012 134:13588-13591 DOI:10.1021/ja3063716 PMID:22860624 PMCID:PMC3425717
- Gotoh, H., Sears, J. E., Eschenmoser, A., Boger, D. L. New insights into the mechanism and an expanded scope of the Fe(III)-mediated vinblastine coupling reaction Journal of the American Chemical Society 2012 134:13240-13243 DOI:10.1021/ja306229x PMID:22856867 PMCID:PMC3430138
- Wolfe, A. L., Duncan, K. K., Parelkar, N. K., Weir, S. J., Vielhauer, G. A., Boger, D. L. A novel, unusually efficacious duocarmycin carbamate prodrug that releases no residual byproduct Journal of Medicinal Chemistry 2012 55:5878-5886 DOI:10.1021/jm300330b PMID:22650244 PMCID:PMC3386426
- Okano, A., James, R. C., Pierce, J. G., Xie, J., Boger, D. L. Silver(I)-promoted conversion of thioamides to amidines: divergent synthesis of a key series of vancomycin aglycon residue 4 amidines that clarify binding behavior to model ligands Journal of the American Chemical Society 2012 134:8790-8793 DOI:10.1021/ja302808p PMID:22568755 PMCID:PMC3365631
- James, R. C., Pierce, J. G., Okano, A., Xie, J., Boger, D. L. Redesign of glycopeptide antibiotics: back to the future ACS Chemical Biology 2012 7:797-804 DOI:10.1021/cb300007j PMID:22330049 PMCID:PMC3356478
- Otrubova, K., Boger, D. L. α-Ketoheterocycle-based inhibitors of Fatty Acid Amide Hydrolase (FAAH) ACS Chemical Neuroscience 2012 3:340-348 DOI:10.1021/cn2001206 PMID:22639704 PMCID:PMC3359644
- Lajiness, J. P., Jiang, W. L., Boger, D. L. Divergent total syntheses of (-)-aspidospermine and (+)-spegazzinine Organic Letters 2012 14:2078-2081 DOI:10.1021/ol300599p PMID:22480368 PMCID:PMC3337885
- Whitby, L. R., Boyle, K. E., Cai, L. F., Yu, X. Q., Gochin, M., Boger, D. L. Discovery of HIV fusion inhibitors targeting gp41 using a comprehensive α-helix mimetic library Bioorganic & Medicinal Chemistry Letters 2012 22:2861-2865 DOI:10.1016/j.bmcl.2012.02.062 PMID:22424973 PMCID:PMC3321071
- Booker, L., Kinsey, S. G., Abdullah, R. A., Blankman, J. L., Long, J. Z., Ezzili, C., Boger, D. L., Cravatt, B. F., Lichtman, A. H. The fatty acid amide hydrolase (FAAH) inhibitor PF-3845 acts in the nervous system to reverse LPS-induced tactile allodynia in mice British Journal of Pharmacology 2012 165:2485-2496 DOI:10.1111/j.1476-5381.2011.01445.x PMID:21506952 PMCID:PMC3423256
- Leggans, E. K., Barker, T. J., Duncan, K. K., Boger, D. L. Iron(III)/NaBH4-mediated additions to unactivated alkenes: synthesis of novel 20'-vinblastine analogues Organic Letters 2012 14:1428-1431 DOI:10.1021/ol300173v PMID:22369097 PMCID:PMC3306530
- Xie, J., Okano, A., Pierce, J. G., James, R. C., Stamm, S., Crane, C. M., Boger, D. L. Total synthesis of [Psi[C(═S)NH]Tpg4]vancomycin aglycon, [Psi[C(═NH)NH]Tpg4]vancomycin aglycon, and related key compounds: reengineering vancomycin for dual D-Ala-D-Ala and D-Ala-D-Lac binding Journal of the American Chemical Society 2012 134:1284-1297 DOI:10.1021/ja209937s PMID:22188323 PMCID:PMC3262083
- Gotoh, H., Duncan, K. K., Robertson, W. M., Boger, D. L. 10 '-fluorovinblastine and 10 '-fluorovincristine: synthesis of a key series of modified vinca alkaloids ACS Medicinal Chemistry Letters 2011 2:948-952 DOI:10.1021/ml200236a PMID:22247789 PMCID:PMC3254105
- Breazzano, S. P., Boger, D. L. Synthesis and stereochemical determination of complestatin A and B (neuroprotectin A and B) Journal of the American Chemical Society 2011 133:18495-18502 DOI:10.1021/ja208570q PMID:21991993 PMCID:PMC3217038
- Xie, J., Pierce, J. G., James, R. C., Okano, A., Boger, D. L. A redesigned vancomycin engineered for dual D-Ala-D-ala And D-Ala-D-Lac binding exhibits potent antimicrobial activity against vancomycin-resistant bacteria Journal of the American Chemical Society 2011 133:13946-13949 DOI:10.1021/ja207142h PMID:21823662 PMCID:PMC3164945
- Boger, D. L. Tetrahedron Young Investigator Award 2011: Carolyn R. Bertozzi Bioorganic & Medicinal Chemistry Letters 2011 21:4944-4944 DOI:10.1016/j.bmcl.2011.08.013 PMID:21840475
- Otrubova, K., Ezzili, C., Boger, D. L. The discovery and development of inhibitors of fatty acid amide hydrolase (FAAH) Bioorganic & Medicinal Chemistry Letters 2011 21:4674-4685 DOI:10.1016/j.bmcl.2011.06.096 PMID:21764305 PMCID:PMC3146581
- Anderson, E. D., Boger, D. L. Inverse electron demand Diels-Alder reactions of 1,2,3-triazines: Pronounced substituent effects on reactivity and cycloaddition scope Journal of the American Chemical Society 2011 133:12285-12292 DOI:10.1021/ja204856a PMID:21736324 PMCID:PMC3150293
- Whitby, L. R., Ando, Y., Setola, V., Vogt, P. K., Roth, B. L., Boger, D. L. Design, synthesis, and validation of a β-turn mimetic library targeting protein-protein and peptide-receptor interactions Journal of the American Chemical Society 2011 133:10184-10194 DOI:10.1021/ja201878v PMID:21609016 PMCID:PMC3134394
- Anderson, E. D., Boger, D. L. Scope of the inverse electron demand Diels-Alder reactions of 1,2,3-triazine Organic Letters 2011 13:2492-2494 DOI:10.1021/ol2007428 PMID:21488676 PMCID:PMC3093666
- Boger, D. L., Blagg, B. S. J., Johnson, D. S., Garbaccio, R. M. Recent advances in medicinal chemistry Bioorganic & Medicinal Chemistry Letters 2011 21:2585-2586 DOI:10.1016/j.bmcl.2011.04.019
- Ezzili, C., Mileni, M., McGlinchey, N., Long, J. Z., Kinsey, S. G., Hochstatter, D. G., Stevens, R. C., Lichtman, A. H., Cravatt, B. F., Bilsky, E. J., Boger, D. L. Reversible competitive α-ketoheterocycle inhibitors of fatty acid amide hydrolase containing additional conformational constraints in the acyl side chain: orally active, long-acting analgesics Journal of Medicinal Chemistry 2011 54:2805-2822 DOI:10.1021/jm101597x PMID:21428410 PMCID:PMC3085948
- Mileni, M., Garfunkle, J., Ezzili, C., Cravatt, B. F., Stevens, R. C., Boger, D. L. Fluoride-mediated capture of a noncovalent bound state of a reversible covalent enzyme inhibitor: X-ray crystallographic analysis of an exceptionally potent α-ketoheterocycle inhibitor of fatty acid amide hydrolase Journal of the American Chemical Society 2011 133:4092-4100 DOI:10.1021/ja110877y PMID:21355555 PMCID:PMC3060301
- Thomas, C. J., Casquilho-Gray, H. E., York, J., DeCamp, D. L., Dai, D. C., Petrilli, E. B., Boger, D. L., Slayden, R. A., Amberg, S. M., Sprang, S. R., Nunberg, J. H. A specific interaction of small molecule entry inhibitors with the envelope glycoprotein complex of the Junin hemorrhagic fever arenavirus Journal of Biological Chemistry 2011 286:6192-6200 DOI:10.1074/jbc.M110.196428 PMID:21159779 PMCID:PMC3057843
- Lajiness, J. P., Boger, D. L. Asymmetric synthesis of 1,2,9,9a-tetrahydrocyclopropa[c]benzo[e]indol-4-one (CBI) Journal of Organic Chemistry 2011 76:583-587 DOI:10.1021/jo102136w PMID:21192653 PMCID:PMC3079324
- Burke, C. P., Swingle, M. R., Honkanen, R. E., Boger, D. L. Total synthesis and evaluation of phostriecin and key structural analogues Journal of Organic Chemistry 2010 75:7505-7513 DOI:10.1021/jo1010203 PMID:20669916 PMCID:PMC2978778
- Tam, A., Gotoh, H., Robertson, W. M., Boger, D. L. Catharanthine C16 substituent effects on the biomimetic coupling with vindoline: preparation and evaluation of a key series of vinblastine analogues Bioorganic & Medicinal Chemistry Letters 2010 20:6408-6410 DOI:10.1016/j.bmcl.2010.09.091 PMID:20932748 PMCID:PMC2957881
- Lajiness, J. P., Robertson, W. M., Dunwiddie, I., Broward, M. A., Vielhauer, G. A., Weir, S. J., Boger, D. L. Design, synthesis, and evaluation of duocarmycin O-amino phenol prodrugs subject to tunable reductive activation Journal of Medicinal Chemistry 2010 53:7731-7738 DOI:10.1021/jm1010397 PMID:20942408 PMCID:PMC2974002
- Ambrus, G., Whitby, L. R., Singer, E. L., Trott, O., Choi, E., Olson, A. J., Boger, D. L., Gerace, L. Small molecule peptidomimetic inhibitors of importin α/β mediated nuclear transport Bioorganic & Medicinal Chemistry 2010 18:7611-7620 DOI:10.1016/j.bmc.2010.08.038 PMID:20869252 PMCID:PMC2966498
- Ezzili, C., Otrubova, K., Boger, D. L. Fatty acid amide signaling molecules Bioorganic & Medicinal Chemistry Letters 2010 20:5959-5968 DOI:10.1016/j.bmcl.2010.08.048 PMID:20817522 PMCID:PMC2942981
- Crane, C. M., Pierce, J. G., Leung, S. S. F., Tirado-Rives, J., Jorgensen, W. L., Boger, D. L. Synthesis and evaluation of selected key methyl ether derivatives of vancomycin aglycon Journal of Medicinal Chemistry 2010 53:7229-7235 DOI:10.1021/jm100946e PMID:20853900 PMCID:PMC2981068
- Lajiness, J. P., Boger, D. L. Synthesis and characterization of a cyclobutane duocarmycin derivative incorporating the 1,2,10,11-tetrahydro-9H-cyclobuta[c]benzo[e]indol-4-one (CbBI) alkylation subunit Journal of the American Chemical Society 2010 132:13936-13940 DOI:10.1021/ja106986f PMID:20839806 PMCID:PMC2952436
- Sasaki, Y., Kato, D., Boger, D. L. Asymmetric total synthesis of vindorosine, vindoline, and key vinblastine analogues Journal of the American Chemical Society 2010 132:13533-13544 DOI:10.1021/ja106284s PMID:20809620 PMCID:PMC2944909
- Patel, P. R., Boger, D. L. Intramolecular Diels-Alder reactions of cyclopropenone ketals Organic Letters 2010 12:3540-3543 DOI:10.1021/ol101375a PMID:20614867 PMCID:PMC2912946
- Chang, M. W., Giffin, M. J., Muller, R., Savage, J., Lin, Y. C., Hong, S., Jin, W., Whitby, L. R., Elder, J. H., Boger, D. L., Torbett, B. E. Identification of broad-based HIV-1 protease inhibitors from combinatorial libraries Biochemical Journal 2010 429:527-532 DOI:10.1042/bj20091645 PMID:20507280 PMCID:PMC3084599
- Patel, P. R., Boger, D. L. Intramolecular 1+2 and 3+2 cycloaddition reactions of cyclopropenone ketals Journal of the American Chemical Society 2010 132:8527-8529 DOI:10.1021/ja103933n PMID:20527885 PMCID:PMC2892887
- Va, P., Campbell, E. L., Robertson, W. M., Boger, D. L. Total synthesis and evaluation of a key series of C5-substituted vinblastine derivatives Journal of the American Chemical Society 2010 132:8489-8495 DOI:10.1021/ja1027748 PMID:20518465 PMCID:PMC2903230
- Shimamura, H., Breazzano, S. P., Garfunkle, J., Kimball, F. S., Trzupek, J. D., Boger, D. L. Total synthesis of complestatin: development of a Pd(0)-mediated indole annulation for macrocyclization Journal of the American Chemical Society 2010 132:7776-7783 DOI:10.1021/ja102304p PMID:20469945 PMCID:PMC2892899
- Robertson, W. M., Kastrinsky, D. B., Hwang, I., Boger, D. L. Synthesis and evaluation of a series of C5'-substituted duocarmycin SA analogs Bioorganic & Medicinal Chemistry Letters 2010 20:2722-2725 DOI:10.1016/j.bmcl.2010.03.078 PMID:20381346 PMCID:PMC2867475
- Boyle, K. E., MacMillan, K. S., Ellis, D. A., Lajiness, J. P., Robertson, W. M., Boger, D. L. Synthesis and evaluation of duocarmycin SA analogs incorporating the methyl 1,2,8,8a-tetrahydrocyclopropa[c]oxazolo[2,3-e]indol-4-one-6-carboxylate (COI) alkylation subunit Bioorganic & Medicinal Chemistry Letters 2010 20:1854-1857 DOI:10.1016/j.bmcl.2010.01.145 PMID:20171886 PMCID:PMC2965170
- Campbell, E. L., Zuhl, A. M., Liu, C. M., Boger, D. L. Total synthesis of (+)-fendleridine (aspidoalbidine) and (+)-1-acetylaspidoalbidine Journal of the American Chemical Society 2010 132:3009-3012 DOI:10.1021/ja908819q PMID:20148585 PMCID:PMC2832086
- Oakdale, J. S., Boger, D. L. Total synthesis of lycogarubin C and lycogalic acid Organic Letters 2010 12:1132-1134 DOI:10.1021/ol100146b PMID:20148525 PMCID:PMC2832087
- Burke, C. P., Haq, N., Boger, D. L. Total synthesis, assignment of the relative and absolute stereochemistry, and structural reassignment of phostriecin (aka Sultriecin) Journal of the American Chemical Society 2010 132:2157-2159 DOI:10.1021/ja9097252 PMID:20108904 PMCID:PMC2824046
- Mileni, M., Garfunkle, J., Ezzili, C., Kimball, F. S., Cravatt, B. F., Stevens, R. C., Boger, D. L. X-ray crystallographic analysis of alpha-ketoheterocycle inhibitors bound to a humanized variant of fatty acid amide hydrolase Journal of Medicinal Chemistry 2010 53:230-240 DOI:10.1021/jm9012196 PMID:19924997 PMCID:PMC2804032
- Kato, D., Sasaki, Y., Boger, D. L. Asymmetric total synthesis of vindoline Journal of the American Chemical Society 2010 132:3685-3687 DOI:10.1021/ja910695e PMID:20187641 PMCID:PMC2854892
- Subramanian, V., Williams, R. M., Boger, D. L., Luger, K. Methods to characterize the effect of DNA-modifying compounds on nucleosomal DNA Methods in Molecular Biology 2010 613:173-192 DOI:10.1007/978-1-60327-418-0_11 PMID:19997884
- MacMillan, K. S., Lajiness, J. P., Cara, C. L., Romagnoli, R., Robertson, W. M., Hwang, I., Baraldi, P. G., Boger, D. L. Synthesis and evaluation of a thio analogue of duocarmycin SA Bioorganic & Medicinal Chemistry Letters 2009 19:6962-6965 DOI:10.1016/j.bmcl.2009.10.063 PMID:19879753 PMCID:PMC2784222
- Garfunkle, J., Kimball, F. S., Trzupek, J. D., Takizawa, S., Shimamura, H., Tomishima, M., Boger, D. L. Total synthesis of chloropeptin II (complestatin) and chloropeptin I Journal of the American Chemical Society 2009 131:16036-16038 DOI:10.1021/ja907193b PMID:19839632 PMCID:PMC2783344
- Fang, X., Nam, J., Shin, D., Rew, Y., Boger, D. L., Walker, S. Functional and biochemical analysis of a key series of ramoplanin analogues Bioorganic & Medicinal Chemistry Letters 2009 19:6189-6191 DOI:10.1016/j.bmcl.2009.09.001 PMID:19783144 PMCID:PMC2767165
- Shi, J., Stover, J. S., Whitby, L. R., Vogt, P. K., Boger, D. L. Small molecule inhibitors of Myc/Max dimerization and Myc-induced cell transformation Bioorganic & Medicinal Chemistry Letters 2009 19:6038-6041 DOI:10.1016/j.bmcl.2009.09.044 PMID:19800226 PMCID:PMC2767179
- MacMillan, K. S., Boger, D. L. Fundamental relationships between structure, reactivity, and biological activity for the duocarmycins and CC-1065 Journal of Medicinal Chemistry 2009 52:5771-5780 DOI:10.1021/jm9006214 PMID:19639994 PMCID:PMC2755654
- Swingle, M. R., Amable, L., Lawhorn, B. G., Buck, S. B., Burke, C. P., Ratti, P., Fischer, K. L., Boger, D. L., Honkanen, R. E. Structure-activity relationship studies of fostriecin, cytostatin, and key analogs, with PP1, PP2A, PP5, and( beta12-beta13)-chimeras (PP1/PP2A and PP5/PP2A), provide further insight into the inhibitory actions of fostriecin family inhibitors Journal of Pharmacology and Experimental Therapeutics 2009 331:45-53 DOI:10.1124/jpet.109.155630 PMID:19592665 PMCID:PMC2766224
- Kinsey, S. G., Long, J. Z., O'Neal, S. T., Abdullah, R. A., Poklis, J. L., Boger, D. L., Cravatt, B. F., Lichtman, A. H. Blockade of endocannabinoid-degrading enzymes attenuates neuropathic pain Journal of Pharmacology and Experimental Therapeutics 2009 330:902-910 DOI:10.1124/jpet.109.155465 PMID:19502530 PMCID:PMC2729802
- Gauss, C. M., Hamasaki, A., Parrish, J. P., MacMillan, K. S., Rayl, T. J., Hwang, I., Boger, D. L. Synthesis and preliminary evaluation of duocarmycin analogues incorporating the 1,2,11,11a-tetrahydrocyclopropa c naphtho 2,3-e indol-4-one (CNI) and 1,2,11,11a-tetrahydrocyclopropa c naphtho 1,2-e indol-4-one (iso-CNI) alkylation subunits Tetrahedron 2009 65:6591-6599 DOI:10.1016/j.tet.2009.02.065 PMID:20161204 PMCID:PMC2713043
- Mileni, M., Garfunkle, J., DeMartino, J. K., Cravatt, B. F., Boger, D. L., Stevens, R. C. Binding and inactivation mechanism of a humanized fatty acid amide hydrolase by alpha-ketoheterocycle inhibitors revealed from cocrystal structures Journal of the American Chemical Society 2009 131:10497-10506 DOI:10.1021/ja902694n PMID:19722626 PMCID:PMC2739126
- Hauschild, K. E., Stover, J. S., Boger, D. L., Ansari, A. Z. CSI-FID: high throughput label-free detection of DNA binding molecules Bioorganic & Medicinal Chemistry Letters 2009 19:3779-3782 DOI:10.1016/j.bmcl.2009.04.097 PMID:19435662 PMCID:PMC2760306
- Whitby, L. R., Lee, A. M., Kunz, S., Oldstone, M. B. A., Boger, D. L. Characterization of lassa virus cell entry inhibitors: Determination of the active enantiomer by asymmetric synthesis Bioorganic & Medicinal Chemistry Letters 2009 19:3771-3774 DOI:10.1016/j.bmcl.2009.04.098 PMID:19428249 PMCID:PMC2742202
- Clark, R. C., Lee, S. Y., Hwang, I., Searcey, M., Boger, D. L. Evaluation of chlorofusin, its seven chromophore diastereomers, and key analogues Tetrahedron Letters 2009 50:3151-3153 DOI:10.1016/j.tetlet.2009.01.081 PMID:20161293 PMCID:PMC2697908
- Shaginian, A., Whitby, L. R., Hong, S., Hwang, I., Farooqi, B., Searcey, M., Chen, J. C., Vogt, P. K., Boger, D. L. Design, synthesis, and evaluation of an α-helix mimetic library targeting protein-protein interactions Journal of the American Chemical Society 2009 131:5564-5572 DOI:10.1021/ja810025g PMID:19334711 PMCID:PMC2765553
- Lee, S. Y., Boger, D. L. Synthesis of the chlorofusin cyclic peptide Tetrahedron 2009 65:3281-3284 DOI:10.1016/j.tet.2008.09.029 PMID:20047009 PMCID:PMC2665043
- Ishikawa, H., Colby, D. A., Seto, S., Va, P., Tam, A., Kakei, H., Rayl, T. J., Hwang, I., Boger, D. L. Total synthesis of vinblastine, vincristine, related natural products, and key structural analogues Journal of the American Chemical Society 2009 131:4904-4916 DOI:10.1021/ja809842b PMID:19292450 PMCID:PMC2727944
- Schlosburg, J. E., Boger, D. L., Cravatt, B. F., Lichtman, A. H. Endocannabinoid modulation of scratching response in an acute allergenic model: a new prospective neural therapeutic target for pruritus Journal of Pharmacology and Experimental Therapeutics 2009 329:314-323 DOI:10.1124/jpet.108.150136 PMID:19168707 PMCID:PMC2670585
- Crane, C. M., Boger, D. L. Synthesis and evaluation of vancomycin aglycon analogues that bear modifications in the N-terminal D-leucyl amino acid Journal of Medicinal Chemistry 2009 52:1471-1476 DOI:10.1021/jm801549b PMID:19209892 PMCID:PMC2765482
- Stover, J. S., Shi, J., Jin, W., Vogt, P. K., Boger, D. L. Discovery of inhibitors of aberrant gene transcription from libraries of DNA binding molecules: Inhibition of LEF-1-mediated gene transcription and oncogenic transformation Journal of the American Chemical Society 2009 131:3342-3348 DOI:10.1021/ja809083d PMID:19216569 PMCID:PMC2787879
- Ishikawa, H., Boger, D. L. Total synthesis of vindoline and related alkaloids Journal of Synthetic Organic Chemistry Japan 2009 67:123-133 DOI:10.5059/yukigoseikyokaishi.67.123
- MacMillan, K. S., Nguyen, T., Hwang, I., Boger, D. L. Total synthesis and evaluation of iso-duocarmycin SA and iso-yatakemycin Journal of the American Chemical Society 2009 131:1187-1194 DOI:10.1021/ja808108q PMID:19154178 PMCID:PMC2646182
- Clark, R. C., Lee, S. Y., Searcey, M., Boger, D. L. The isolation, total synthesis and structure elucidation of chlorofusin, a natural product inhibitor of the p53-mDM2 protein-protein interaction Natural Product Reports 2009 26:465-477 DOI:10.1039/b821676b PMID:19642417 PMCID:PMC2719831
- MacMillan, K. S., Boger, D. L. An additional spirocyclization for duocarmycin SA Journal of the American Chemical Society 2008 130:16521-16523 DOI:10.1021/ja806593w PMID:19554689 PMCID:PMC2891557
- Slaymaker, I. M., Bracey, M., Mileni, M., Garfunkle, J., Cravatt, B. F., Boger, D. L., Stevens, R. C. Correlation of inhibitor effects on enzyme activity and thermal stability for the integral membrane protein fatty acid amide hydrolase Bioorganic & Medicinal Chemistry Letters 2008 18:5847-5850 DOI:10.1016/j.bmcl.2008.06.086 PMID:18644727 PMCID:PMC2794692
- DeMartino, J. K., Garfunkle, J., Hochstatter, D. G., Cravatt, B. F., Boger, D. L. Exploration of a fundamental substituent effect of α-ketoheterocycle enzyme inhibitors: Potent and selective inhibitors of fatty acid amide hydrolase Bioorganic & Medicinal Chemistry Letters 2008 18:5842-5846 DOI:10.1016/j.bmcl.2008.06.084 PMID:18639454 PMCID:PMC2582052
- DeMartino, J. K., Boger, D. L. Glycinamide ribonucleotide transformylase (GAR Tfase) as a target for cancer therapy Drugs of the Future 2008 33:969-979 DOI:10.1358/dof.2008.33.11.1247542
- Clark, R. C., Lee, S. Y., Boger, D. L. Total synthesis of chlorofusin, its seven chromophore diastereomers, and key partial structures Journal of the American Chemical Society 2008 130:12355-12369 DOI:10.1021/ja8012819 PMID:18712872 PMCID:PMC2587114
- DeMartino, J. K., Hwang, I., Connelly, S., Wilson, I. A., Boger, D. L. Asymmetric synthesis of inhibitors of glycinamide ribonucleotide transformylase Journal of Medicinal Chemistry 2008 51:5441-5448 DOI:10.1021/jm800555h PMID:18686942 PMCID:PMC2559975
- Garfunkle, J., Ezzili, C., Rayl, T. J., Hochstatter, D. G., Hwang, I., Boger, D. L. Optimization of the central heterocycle of alpha-ketoheterocycle inhibitors of fatty acid amide hydrolase Journal of Medicinal Chemistry 2008 51:4392-4403 DOI:10.1021/jm800136b PMID:18630870 PMCID:PMC2556205
- Lee, A. M., Rojek, J. M., Spiropoulou, C. F., Gundersen, A. T., Jin, W., Shaginian, A., York, J., Nunberg, J. H., Boger, D. L., Oldstone, M. B. A., Kunz, S. Unique small molecule entry inhibitors of hemorrhagic fever arenaviruses Journal of Biological Chemistry 2008 283:18734-18742 DOI:10.1074/jbc.M802089200 PMID:18474596 PMCID:PMC2441566
- Di Micco, S., Boger, D. L., Riccio, R., Bifulco, G. Structural features of the (+)-Yatakemycin/d(GACTAATTGAC)-(GTCAATTAGTC) complex: Quantum mechanical calculation of NMR parameters as a tool for the characterization of ligand/DNA Interactions European Journal of Organic Chemistry 2008 2454-2462 DOI:10.1002/ejoc.200701212
- Lu, X. H., Vogt, P. K., Boger, D. L., Lunec, J. Disruption of the MYC transcriptional function by a small-molecule antagonist of MYC/MAX dimerization Oncology Reports 2008 19:825-830 PMID:18288422
- Kimball, F. S., Romero, F. A., Ezzili, C., Garfunkle, J., Rayl, T. J., Hochstatter, D. G., Hwang, I., Boger, D. L. Optimization of alpha-ketooxazole inhibitors of fatty acid amide hydrolase Journal of Medicinal Chemistry 2008 51:937-947 DOI:10.1021/jm701210y PMID:18247553 PMCID:PMC2734917
- Ishikawa, H., Colby, D. A., Boger, D. L. Direct coupling of catharanthine and vindoline to provide vinblastine: Total synthesis of (+)- and ent-(-)-vinblastine Journal of the American Chemical Society 2008 130:420-421 DOI:10.1021/ja078192m PMID:18081297 PMCID:PMC2570212
- Tichenor, M. S., Boger, D. L. Yatakemycin: Total synthesis, DNA alkylation, and biological properties Natural Product Reports 2008 25:220-226 DOI:10.1039/b705665f PMID:18389136
- Jin, W., Trzupek, J. D., Rayl, T. J., Broward, M. A., Vielhauer, G. A., Weir, S. J., Hwang, I., Boger, D. L. A unique class of duocarmycin and CC-1065 analogues subject to reductive activation Journal of the American Chemical Society 2007 129:15391-15397 DOI:10.1021/ja075398e PMID:18020335 PMCID:PMC2519901
- Tichenor, M. S., MacMillan, K. S., Stover, J. S., Wolkenberg, S. E., Pavani, M. G., Zanella, L., Zaid, A. N., Spalluto, G., Rayl, T. J., Hwang, I., Baraldi, P. G., Boger, D. L. Rational design, synthesis, and evaluation of key analogues of CC-1065 and the duocarmycins Journal of the American Chemical Society 2007 129:14092-14099 DOI:10.1021/ja073989z PMID:17948994 PMCID:PMC2531197
- Tichenor, M. S., MacMillan, K. S., Trzupek, J. D., Rayl, T. J., Hwang, I., Boger, D. L. Systematic exploration of the structural features of yatakemycin impacting DNA alkylation and biological activity Journal of the American Chemical Society 2007 129:10858-10869 DOI:10.1021/ja072777z PMID:17691783 PMCID:PMC2519902
- Lee, S. Y., Clark, R. C., Boger, D. L. Total synthesis, stereochemical reassignment, and absolute configuration of chlorofusin Journal of the American Chemical Society 2007 129:9860-9861 DOI:10.1021/ja073264v PMID:17637057 PMCID:PMC2531192
- Nam, J., Shin, D., Rew, Y., Boger, D. L. Alanine scan of [L-Dap2]ramoplanin A2 aglycon: Assessment of the importance of each residue Journal of the American Chemical Society 2007 129:8747-8755 DOI:10.1021/ja068573k PMID:17592838 PMCID:PMC2593884
- Hardouin, C., Kelso, M. J., Romero, F. A., Rayl, T. J., Leung, D., Hwang, I., Cravatt, B. F., Boger, D. L. Structure-activity relationships of alpha-ketooxazole inhibitors of fatty acid amide hydrolase Journal of Medicinal Chemistry 2007 50:3359-3368 DOI:10.1021/jm061414r PMID:17559203 PMCID:PMC2531194
- Xu, L., Chong, Y. H., Hwang, I. Y., D'Onofrio, A., Amore, K., Beardsley, G. P., Li, C. L., Olson, A. J., Boger, D. L., Wilson, I. A. Structure-based design, synthesis, evaluation, and crystal structures of transition state analogue inhibitors of inosine monophosphate cyclohydrolase Journal of Biological Chemistry 2007 282:13033-13046 DOI:10.1074/jbc.M607293200 PMID:17324932
- Ishikawa, H., Boger, D. L. Total synthesis of (-)- and ent-(+)-4-desacetoxy-5-desethylvindoline Heterocycles 2007 72:95-102 DOI:10.3987/COM-06-S(K)8
- Romero, F. A., Du, W., Hwang, I., Rayl, T. J., Kimball, F. S., Leung, D., Hoover, H. S., Apodaca, R. L., Breitenbucher, J. G., Cravatt, B. F., Boger, D. L. Potent and selective alpha-ketoheterocycle-based inhibitors of the anandamide and oleamide catabolizing enzyme, fatty acid amide hydrolase Journal of Medicinal Chemistry 2007 50:1058-1068 DOI:10.1021/jm0611509 PMID:17279740 PMCID:PMC2531193
- Dickerson, T. J., Clancy, C. M., Johnson, E. A., Baldwin, M. R., Jin, W., Barbieri, J. T., Tepp, W. H., Eubanks, L. M., Malizio, C. J., Goodnough, M. C., Janda, K. D., Hong, S., et al. An in vitro and in vivo disconnect uncovered through high-throughput identification of botulinum neurotoxin A antagonists Proceedings of the National Academy of Sciences of the United States of America 2007 104:2602-2607 DOI:10.1073/pnas.0611213104 PMID:17293454 PMCID:PMC1815229
- Lawhorn, B. G., Boga, S. B., Wolkenberg, S. E., Boger, D. L. Total synthesis of cytostatin Heterocycles 2006 70:65-70 DOI:10.3987/COM-06-S(W)13
- Lawhorn, B. G., Boga, S. B., Wolkenberg, S. E., Colby, D. A., Gauss, C. M., Swingle, M. R., Amable, L., Honkanen, R. E., Boger, D. L. Total synthesis and evaluation of cytostatin, its C10-C11 diastereomers, and additional key analogues: Impact on PP2A inhibition Journal of the American Chemical Society 2006 128:16720-16732 DOI:10.1021/ja066477d PMID:17177422 PMCID:PMC2566737
- Tichenor, M. S., Trzupek, J. D., Kastrinsky, D. B., Shiga, F., Hwang, I., Boger, D. L. Asymmetric total synthesis of (+)- and ent-(-)-yatakemycin and duocarmycin SA: evaluation of yatakemycin key partial structures and its unnatural enantiomer Journal of the American Chemical Society 2006 128:15683-15696 DOI:10.1021/ja064228j PMID:17147378 PMCID:PMC2515590
- Romero, F. A., Hwang, I., Boger, D. L. Delineation of a fundamental alpha-ketoheterocycle substituent effect for use in the design of enzyme inhibitors Journal of the American Chemical Society 2006 128:14004-14005 DOI:10.1021/ja064522b PMID:17061864 PMCID:PMC2501112
- Schnermann, M. J., Romero, F. A., Hwang, I., Nakamaru-Ogiso, E., Yagi, T., Boger, D. L. Total synthesis of piericidin A1 and B1 and key analogues Journal of the American Chemical Society 2006 128:11799-11807 DOI:10.1021/ja0632862 PMID:16953619 PMCID:PMC2531196
- Elliott, G. I., Fuchs, J. R., Blagg, B. S. J., Ishikawa, H., Tao, H. C., Yuan, Z. Q., Boger, D. L. Intramolecular Diels-Alder/1,3-dipolar cycloaddition cascade of 1,3,4-oxadiazoles Journal of the American Chemical Society 2006 128:10589-10595 DOI:10.1021/ja0612549 PMID:16895427 PMCID:PMC2587417
- Ishikawa, H., Elliott, G. I., Velcicky, J., Choi, Y., Boger, D. L. Total synthesis of (-)- and ent-(+)-vindoline and related alkaloids Journal of the American Chemical Society 2006 128:10596-10612 DOI:10.1021/ja061256t PMID:16895428 PMCID:PMC2531198
- DeMartino, J. K., Hwang, I., Xu, L., Wilson, I. A., Boger, D. L. Discovery of a potent, nonpolyglutamatable inhibitor of glycinamide ribonucleotide transformylase Journal of Medicinal Chemistry 2006 49:2998-3002 DOI:10.1021/jm0601147 PMID:16686541 PMCID:PMC2531195
- Crowley, B. M., Boger, D. L. Total synthesis and evaluation of [Ψ[CH(2)NH]Tpg(4)]vancomycin aglycon: reengineering vancomycin for dual D-Ala-D-Ala and D-Ala-D-Lac binding Journal of the American Chemical Society 2006 128:2885-2892 DOI:10.1021/ja0572912 PMID:16506767 PMCID:PMC2586002
- Clark, R. C., Pfeiffer, S. S., Boger, D. L. Diastereoselective Diels-Alder reactions of N-sulfonyl-1-aza-1,3-butadienes with optically active enol ethers: An asymmetric variant of the 1-azadiene Diels-Alder reaction Journal of the American Chemical Society 2006 128:2587-2593 DOI:10.1021/ja0571646 PMID:16492042 PMCID:PMC2525448
- Trzupek, J. D., Gottesfeld, J. M., Boger, D. L. Alkylation of duplex DNA in nucleosome core particles by duocarmycin SA and yatakemycin Nature Chemical Biology 2006 2:79-82 DOI:10.1038/nchembio761 PMID:16415862
- Hamasaki, A., Ducray, R., Boger, D. L. Two novel 1,2,4,5-tetrazines that participate in inverse electron demand Diels-Alder reactions with an unexpected regioselectivity Journal of Organic Chemistry 2006 71:185-193 DOI:10.1021/jo051832o PMID:16388634 PMCID:PMC2525609
- Fang, X., Tiyanont, K., Zhang, Y., Wanner, J., Boger, D., Walker, S. The mechanism of action of ramoplanin and enduracidin Molecular Biosystems 2006 2:69-76 DOI:10.1039/b515328j PMID:16880924
- Elliott, G. I., Velcicky, J., Ishikawa, H., Li, Y. K., Boger, D. L. Total synthesis of (-)- and ent-(+)-vindorosine: Tandem intramolecular Diels-Alder/1,3-dipolar cycloaddition of 1,3,4-oxadiazoles Angewandte Chemie-International Edition 2006 45:620-622 DOI:10.1002/anie.200503024 PMID:16355429
- Guimaraes, C. R. W., Boger, D. L., Jorgensen, W. L. Elucidation of fatty acid amide hydrolase inhibition by potent alpha-ketoheterocycle derivatives from Monte Carlo simulations Journal of the American Chemical Society 2005 127:17377-17384 DOI:10.1021/ja055438j PMID:16332087
- Schnermann, M. J., Boger, D. L. Total synthesis of piericidin A1 and B1 Journal of the American Chemical Society 2005 127:15704-15705 DOI:10.1021/ja055041f PMID:16277503 PMCID:PMC2504520
- Chou, T. C., Guan, Y. B., Soenen, D. R., Danishefsky, S. J., Boger, D. L. Potent reversal of multidrug resistance by ningalins and its use in drug combinations against human colon carcinoma xenograft in nude mice Cancer Chemotherapy and Pharmacology 2005 56:379-390 DOI:10.1007/s00280-005-1019-y PMID:15875185
- Choi, Y. G., Ishikawa, H., Velcicky, J., Elliott, G. I., Miller, M. M., Boger, D. L. Total synthesis of (-)- and ent-(+)-vindoline Organic Letters 2005 7:4539-4542 DOI:10.1021/o1051975x PMID:16178578
- Boger, D. L. Bioorganic & Medicinal Chemistry Letters Symposia-in-Print Bioorganic & Medicinal Chemistry Letters 2005 15:3652-3652 DOI:10.1016/j.bmcl.2005.07.002
- Hamasaki, A., Zimpleman, J. M., Hwang, I., Boger, D. L. Total synthesis of ningalin D Journal of the American Chemical Society 2005 127:10767-10770 DOI:10.1021/ja0526416 PMID:16045367 PMCID:PMC2480523
- Capps, K. J., Humiston, J., Dominique, R., Hwang, I., Boger, D. L. Discovery of aicar tfase inhibitors that disrupt requisite enzyme dimerization Bioorganic & Medicinal Chemistry Letters 2005 15:2840-2844 DOI:10.1016/j.bcml.2005.03.094 PMID:15911265
- Cheng, H., Chong, Y. H., Hwang, I., Tavassoli, A., Zhang, Y., Wilson, I. A., Benkovic, S. J., Boger, D. L. Design, synthesis, and biological evaluation of 10-methanesulfonyl-DDACTHF, 10-methanesulfonyl-5-DACTHF, and 10-methylthio-DDACTHF as potent inhibitors of GAR Tfase and the de novo purine biosynthetic pathway Bioorganic & Medicinal Chemistry 2005 13:3577-3585 DOI:10.1016/j.bmc.2004.12.004 PMID:15848770
- Cheng, H., Hwang, I., Chong, Y. H., Tavassoli, A., Webb, M. E., Zhang, Y., Wilson, I. A., Benkovic, S. J., Boger, D. L. Synthesis and biological evaluation of N-{4- 5-(2,4-diamino-6-oxo-1,6-dihydropyrimidin-5-yl)-2-(2,2,2-trifluoro acetyl)pentyl)benzoyl}-L-glutamic acid as a potential inhibitor of GAR Tfase and the de novo purine biosynthetic pathway Bioorganic & Medicinal Chemistry 2005 13:3593-3599 DOI:10.1016/j.bme.2004.11.049 PMID:15848772
- Chong, Y., Hwang, I., Tavassoli, A., Zhang, Y., Wilson, I. A., Benkovic, S. J., Boger, D. L. Synthesis and biological evaluation of α- and γ-carboxamide derivatives of 10-CF3CO-DDACTHF Bioorganic & Medicinal Chemistry 2005 13:3587-3592 DOI:10.1016/j.bme.2004.11.050 PMID:15848771
- Boger, D. L., Miyauchi, H., Du, W., Hardouin, C., Fecik, R. A., Cheng, H., Hwang, I., Hedrick, M. P., Leung, D., Acevedo, O., Guimaraes, C. R. W., Jorgensen, W. L., et al. Discovery of a potent, selective, and efficacious class of reversible alpha-ketoheterocycle inhibitors of fatty acid amide hydrolase effective as analgesics Journal of Medicinal Chemistry 2005 48:1849-1856 DOI:10.1021/jm049614v PMID:15771430 PMCID:PMC2492884
- Leung, D., Du, W., Hardouin, C., Cheng, H., Hwang, I., Cravatt, B. F., Boger, D. L. Discovery of an exceptionally potent and selective class of fatty acid amide hydrolase inhibitors enlisting proteome-wide selectivity screening: concurrent optimization of enzyme inhibitor potency and selectivity Bioorganic & Medicinal Chemistry Letters 2005 15:1423-1428 DOI:10.1016/j.bmcl.2004.12.085 PMID:15713400
- Walker, S., Chen, L., Hu, Y. N., Rew, Y., Shin, D. W., Boger, D. L. Chemistry and biology of ramoplanin: A lipoglycodepsipeptide with potent antibiotic activity Chemical Reviews 2005 105:449-475 DOI:10.1021/cr030106n PMID:15700952
- Du, W., Hardouin, C., Cheng, H., Hwang, I., Boger, D. L. Heterocyclic sulfoxide and sulfone inhibitors of fatty acid amide hydrolase Bioorganic & Medicinal Chemistry Letters 2005 15:103-106 DOI:10.1016/j.bmcl.2004.10.025 PMID:15582420
- Yuan, Z. Q., Ishikawa, H., Boger, D. L. Total synthesis of natural (-)- and ent-(+)-4-desacetoxy-6,7-dihydrovindorosine and natural and ent-minovine: Oxadiazole tandem intramolecular Diels-Alder/1,3-dipolar cycloaddition reaction Organic Letters 2005 7:741-744 DOI:10.1021/ol050017s PMID:15704939 PMCID:PMC2587128
- Tao, H. C., Hwang, I. K., Boger, D. L. Multidrug resistance reversal activity of permethyl ningalin B amide derivatives Bioorganic & Medicinal Chemistry Letters 2004 14:5979-5981 DOI:10.1016/j.bmcl.2004.10.002 PMID:15546712
- Tse, W. C., Boger, D. L. Sequence-selective DNA recognition: natural products and nature's lessons Chemistry & Biology 2004 11:1607-1617 DOI:10.1016/j.chembiol.2003.08.012 PMID:15610844
- Parrish, J. P., Trzupek, J. D., Hughes, T. V., Hwang, I., Boger, D. L. Synthesis and evaluation of N-aryl and N-alkenyl CBI derivatives Bioorganic & Medicinal Chemistry 2004 12:5845-5856 DOI:10.1016/j.bmc.2004.08.032 PMID:15498660
- Lichtman, A. H., Leung, D., Shelton, C. C., Saghatelian, A., Hardouin, C., Boger, D. L., Cravatt, B. F. Reversible inhibitors of fatty acid amide hydrolase that promote analgesia: evidence for an unprecedented combination of potency and selectivity Journal of Pharmacology and Experimental Therapeutics 2004 311:441-448 DOI:10.1124/jpet.104.069401 PMID:15229230
- Shin, D., Rew, Y., Boger, D. L. Total synthesis and structure of the ramoplanin A1 and A3 aglycons: two minor components of the ramoplanin complex Proceedings of the National Academy of Sciences of the United States of America 2004 101:11977-11979 DOI:10.1073/pnas.0401419101 PMID:15175429 PMCID:PMC514419
- Lee, P. S., Du, W., Boger, D. L., Jorgensen, W. L. Energetic preferences for alpha,beta versus beta,gamma unsaturation Journal of Organic Chemistry 2004 69:5448-5453 DOI:10.1021/jo049365y PMID:15287795
- Ham, Y. W., Boger, D. L. A powerful selection assay for mixture libraries of DNA alkylating agents Journal of the American Chemical Society 2004 126:9194-9195 DOI:10.1021/ja0477930 PMID:15281804
- Tichenor, M. S., Kastrinsky, D. B., Boger, D. L. Total synthesis, structure revision, and absolute configuration of (+)-yatakemycin Journal of the American Chemical Society 2004 126:8396-8398 DOI:10.1021/ja0472735 PMID:15237994
- Lillo, A. M., Sun, C. Z., Gao, C., Ditzel, H., Parrish, J., Gauss, C. M., Moss, J., Felding-Habermann, B., Wirsching, P., Boger, D. L., Janda, K. D. A human single-chain antibody specific for integrin alpha(3)beta(1) capable of cell internalization and delivery of antitumor agents Chemistry & Biology 2004 11:897-906 DOI:10.1016/j.chembiol.2004.04.018 PMID:15271348
- Chen, L., Yuan, Y. Q., Helm, J. S., Hu, Y. N., Rew, Y., Shin, D. W., Boger, D. L., Walker, S. Dissecting ramoplanin: mechanistic analysis of synthetic ramoplanin analogues as a guide to the design of improved antibiotics Journal of the American Chemical Society 2004 126:7462-7463 DOI:10.1021/ja047879t PMID:15198592
- Crowley, B. M., Mori, Y., McComas, C. C., Tang, D. T., Boger, D. L. Total synthesis of the ristocetin aglycon Journal of the American Chemical Society 2004 126:4310-4317 DOI:10.1021/ja039795a PMID:15053621
- Kastrinsky, D. B., Boger, D. L. Effective asymmetric synthesis of 1,2,9,9a-tetrahydrocyclopropa c benzo e indol-4-one (cbi) Journal of Organic Chemistry 2004 69:2284-2289 DOI:10.1021/jo035465x PMID:15049620
- Rew, Y., Shin, D., Hwang, I., Boger, D. L. Total synthesis and examination of three key analogues of ramoplanin: a lipoglycodepsipeptide with potent antibiotic activity Journal of the American Chemical Society 2004 126:1041-1043 DOI:10.1021/ja039671y PMID:14746470
- Parrish, J. P., Hughes, T. V., Hwang, I. Y., Boger, D. L. Establishing the parabolic relationship between reactivity and activity for derivatives and analogues of the duocarmycin and CC-1065 alkylation subunits Journal of the American Chemical Society 2004 126:80-81 DOI:10.1021/ja038162t PMID:14709069
- Tse, W. C., Boger, D. L. A fluorescent intercalator displacement assay for establishing DNA binding selectivity and affinity Accounts of Chemical Research 2004 37:61-69 DOI:10.1021/ar030113y PMID:14730995
- Desai, P., Pfeiffer, S. S., Boger, D. L. Synthesis of the chlorofusin cyclic peptide: assignment of the asparagine stereochemistry Organic Letters 2003 5:5047-5050 DOI:10.1021/ol036083g PMID:14682761
- Buck, S. B., Hardouin, C., Ichikawa, S., Soenen, D. R., Gauss, C. M., Hwang, I., Swingle, M. R., Bonness, K. M., Honkanen, R. E., Boger, D. L. Fundamental role of the fostriecin unsaturated lactone and implications for selective protein phosphatase inhibition Journal of the American Chemical Society 2003 125:15694-15695 DOI:10.1021/ja038672n PMID:14677930
- Parrish, J. P., Kastrinsky, D. B., Hwang, I., Boger, D. L. Synthesis and evaluation of duocarmycin and CC-1065 analogues incorporating the 1,2,9,9a-tetrahydrocyclopropa c benz e -3-azaindol-4-one (CBA) alkylation subunit Journal of Organic Chemistry 2003 68:8984-8990 DOI:10.1021/jo035119f PMID:14604371
- Bassarello, C., Cimino, P., Bifulco, G., Boger, D. L., Smith, J. A., Chazin, W. J., Gomez-Paloma, L. NMR structure of the (+)-CPI-indole/d(GACTAATTGAC)-d(GTCAATTAGTC) covalent complex ChemBioChem 2003 4:1188-1193 DOI:10.1002/cbic.200300642 PMID:14613110
- Yeung, B. K. S., Tse, W. C., Boger, D. L. Determination of binding affinities of triplex forming oligonucleotides using a fluorescent intercalator displacement (FID) assay Bioorganic & Medicinal Chemistry Letters 2003 13:3801-3804 DOI:10.1016/j.bmcl.2003.07.005 PMID:14552783
- Ham, Y. W., Tse, W. C., Boger, D. L. High-resolution assessment of protein DNA binding affinity and selectivity utilizing a fluorescent intercalator displacement (FID) assay Bioorganic & Medicinal Chemistry Letters 2003 13:3805-3807 DOI:10.1016/j.bmcl.2003.06.002 PMID:14552784
- Marsilje, T. H., Hedrick, M. P., Desharnais, J., Capps, K., Tavassoli, A., Zhang, Y., Wilson, I. A., Benkovic, S. J., Boger, D. L. 10-(2-benzoxazolcarbonyl)-5,10-dideaza-acyclic-5,6,7,8-tetrahydrofolic acid: a potential inhibitor of GAR transformylase and AICAR transformylase Bioorganic & Medicinal Chemistry 2003 11:4503-4509 DOI:10.1016/s0968-0896(03)00457-7 PMID:13129586
- Tse, W. C., Ishii, T., Boger, D. L. Comprehensive high-resolution analysis of hairpin polyamides utilizing a fluorescent intercalator displacement (FID) assay Bioorganic & Medicinal Chemistry 2003 11:4479-4486 DOI:10.1016/s0968-0896(03)00455-3 PMID:13129584
- Desharnais, J., Hwang, I., Zhang, Y., Tavassoli, A., Baboval, J., Benkovic, S. J., Wilson, I. A., Boger, D. L. Design, synthesis and biological evaluation of 10-CF3CO-DDACTHF analogues and derivatives as inhibitors of GAR Tfase and the de novo purine biosynthetic pathway Bioorganic & Medicinal Chemistry 2003 11:4511-4521 DOI:10.1016/s0968-0896(03)00458-9 PMID:13129587
- Marsilje, T. H., Hedrick, M. P., Desharnais, J., Tavassoli, A., Zhang, Y., Wilson, I. A., Benkovic, S. J., Boger, D. L. Design, synthesis, and biological evaluation of simplified alpha-keto heterocycle, trifluoromethyl ketone, and formyl substituted folate analogues as potential inhibitors of GAR transformylase and AICAR transformylase Bioorganic & Medicinal Chemistry 2003 11:4487-4501 DOI:10.1016/s0968-0896(03)00456-5 PMID:13129585
- Parrish, J. P., Kastrinsky, D. B., Wolkenberg, S. E., Igarashi, Y., Boger, D. L. DNA alkylation properties of yatakemycin Journal of the American Chemical Society 2003 125:10971-10976 DOI:10.1021/ja035984h PMID:12952479
- Parrish, J. P., Kastrinsky, D. B., Stauffer, F., Hedrick, M. P., Hwang, I., Boger, D. L. Establishment of substituent effects in the DNA binding subunit of CBI analogues of the duocarmycins and CC-1065 Bioorganic & Medicinal Chemistry 2003 11:3815-3838 DOI:10.1016/s0968-0896(03)00194-9 PMID:12901927
- McComas, C. C., Crowley, B. M., Boger, D. L. Partitioning the loss in vancomycin binding affinity for D-Ala-D-Lac into lost H-bond and repulsive lone pair contributions Journal of the American Chemical Society 2003 125:9314-9315 DOI:10.1021/ja035901x PMID:12889959
- Parrish, J. P., Kastrinsky, D. B., Boger, D. L. Synthesis and X-ray analysis of an unprecedented and stable 2-aza-4,4-spirocyclopropacyclohexadienone Organic Letters 2003 5:2577-2579 DOI:10.1021/ol035000t PMID:12841785
- Yeung, B. K. S., Boger, D. L. Synthesis of isochrysohermidin-distamycin hybrids Journal of Organic Chemistry 2003 68:5249-5253 DOI:10.1021/jo034326c PMID:12816485
- Leung, D., Hardouin, C., Boger, D. L., Cravatt, B. F. Discovering potent and selective reversible inhibitors of enzymes in complex proteomes Nature Biotechnology 2003 21:687-691 DOI:10.1038/nbt826 PMID:12740587
- Zhang, Y., Desharnais, J., Marsilje, T. H., Li, C. L., Hedrick, M. P., Gooljarsingh, L. T., Tavassoli, A., Benkovic, S. J., Olson, A. J., Boger, D. L., Wilson, I. A. Rational design, synthesis, evaluation, and crystal structure of a potent inhibitor of human GAR Tfase: 10-(trifluoroacetyl)-5,10-dideazaacyclic-5,6,7,8-tetrahydrofolic acid Biochemistry 2003 42:6043-6056 DOI:10.1021/bi034219c PMID:12755606
- Soenen, D. R., Hwang, I., Hedrick, M. P., Boger, D. L. Multidrug resistance reversal activity of key ningalin analogues Bioorganic & Medicinal Chemistry Letters 2003 13:1777-1781 DOI:10.1016/s0960-894x(03)00294-4 PMID:12729663
- Krenitsky, P. J., Boger, D. L. Synthesis of the (S,S,S)-diastereomer of the 15-membered biaryl ring system of RP 66453 Tetrahedron Letters 2003 44:4019-4022 DOI:10.1016/s0040-4039(03)00856-6
- Soenen, D. R., Zimpleman, J. M., Boger, D. L. Synthesis and inverse electron demand Diels-Alder reactions of 3,6-bis(3,4-dimethoxybenzoyl)-1,2,4,5-tetrazine Journal of Organic Chemistry 2003 68:3593-3598 DOI:10.1021/jo020713v PMID:12713365
- Boger, D. L. Solution-phase synthesis of combinatorial libraries designed to modulate protein-protein or protein-DNA interactions Bioorganic & Medicinal Chemistry 2003 11:1607-1613 DOI:10.1016/s0968-0896(03)00031-2 PMID:12659745
- Wanner, J., Tang, D. T., McComas, C. C., Crowley, B. M., Jiang, W. L., Moss, J., Boger, D. L. A new and improved method for deglycosidation of glycopeptide antibiotics exemplified with vancomycin, ristocetin, and ramoplanin Bioorganic & Medicinal Chemistry Letters 2003 13:1169-1173 DOI:10.1016/s0960-894x(03)00051-9 PMID:12643936
- Jiang, W. L., Wanner, J., Bounaud, P. Y., Boger, D. L. Total synthesis of the ramoplanin a2 and ramoplanose aglycon Journal of the American Chemical Society 2003 125:1877-1887 DOI:10.1021/ja0212314 PMID:12580615
- Boger, D. L., Desharnais, J., Capps, K. Solution-phase combinatorial libraries: modulating cellular signaling by targeting protein-protein or protein-DNA interactions Angewandte Chemie-International Edition 2003 42:4138-4176 DOI:10.1002/anie.200300574 PMID:14502729
- McComas, C. C., Crowley, B. M., Hwang, I., Boger, D. L. Synthesis and evaluation of methyl ether derivatives of the vancomycin, teicoplanin, and ristocetin aglycon methyl esters Bioorganic & Medicinal Chemistry Letters 2003 13:2933-2936 DOI:10.1016/s0960-894x(03)00513-4 PMID:14611861
- Zhang, Y., Desharnais, J., Greasley, S. E., Beardsley, G. P., Boger, D. L., Wilson, I. A. Crystal structures of human GAR Tfase at low and high pH and with substrate β-GAR Biochemistry 2002 41:14206-14215 DOI:10.1021/bi020522m PMID:12450384
- Lewy, D. S., Gauss, C. M., Soenen, D. R., Boger, D. L. Fostriecin: Chemistry and biology Current Medicinal Chemistry 2002 9:2005-2032 PMID:12369868
- Ambroise, Y., Yaspan, B., Ginsberg, M. H., Boger, D. L. Inhibitors of cell migration that inhibit intracellular paxillin/alpha a binding: A well-documented use of positional scanning libraries Chemistry & Biology 2002 9:1219-1226 DOI:10.1016/s1074-5521(02)00246-6 PMID:12445772
- Wolkenberg, S. E., Boger, D. L. Total synthesis of anhydrolycorinone utilizing sequential intramolecular Diels-Alder reactions of a 1,3,4-oxadiazole Journal of Organic Chemistry 2002 67:7361-7364 DOI:10.1021/jo030437k PMID:12375965
- Wilkie, G. D., Elliott, G. I., Blagg, B. S. J., Wolkenberg, S. E., Soenen, D. R., Miller, M. M., Pollack, S., Boger, D. L. Intramolecular Diels-Alder and tandem intramolecular Diels-Alder/1,3-dipolar cycloaddition reactions of 1,3,4-oxadiazoles Journal of the American Chemical Society 2002 124:11292-11294 DOI:10.1021/ja027533n PMID:12236743
- Woods, C. R., Faucher, N., Eschgfaller, B., Bair, K. W., Boger, D. L. Synthesis and DNA binding properties of saturated distamycin analogues Bioorganic & Medicinal Chemistry Letters 2002 12:2647-2650 DOI:10.1016/s0960-894x(02)00467-5 PMID:12182879
- Woods, C. R., Ishii, T., Boger, D. L. Synthesis and DNA binding properties of iminodiacetic acid-linked polyamides: characterization of cooperative extended 2 : 1 side-by-side parallel binding Journal of the American Chemical Society 2002 124:10676-10682 DOI:10.1021/ja026588m PMID:12207521
- Blagg, B. S. J., Boger, D. L. Total synthesis of (+)-camptothecin Tetrahedron 2002 58:6343-6349 DOI:10.1016/s0040-4020(02)00633-6
- Marsilje, T. H., Labroli, M. A., Hedrick, M. P., Jin, Q., Desharnais, J., Baker, S. J., Gooljarsingh, L. T., Ramcharan, J., Tavassoli, A., Zhang, Y., Wilson, I. A., Beardsley, G. P., et al. 10-formyl-5,10-dideaza-acyclic-5,6,7,8-tetrahydrofolic acid (10-formyl-DDACTHF): a potent cytotoxic agent acting by selective inhibition of human GAR Tfase and the de novo purine biosynthetic pathway Bioorganic & Medicinal Chemistry 2002 10:2739-2749 DOI:10.1016/s0968-0896(02)00102-5 PMID:12057663
- Wolkenberg, S. E., Boger, D. L. Mechanisms of in situ activation for DNA-targeting antitumor agents Chemical Reviews 2002 102:2477-2495 DOI:10.1021/cr010046q PMID:12105933
- Chen, Y., Bilban, M., Foster, C. A., Boger, D. L. Solution-phase parallel synthesis of a pharmacophore library of hun-7293 analogues: a general chemical mutagenesis approach to defining structure-function properties of naturally occurring cyclic (depsi)peptides Journal of the American Chemical Society 2002 124:5431-5440 DOI:10.1021/ja020166v PMID:11996584
- Jiang, W. L., Wanner, J., Bounaud, P. Y., Boger, D. L. Total synthesis of the ramoplanin a2 and ramoplanose aglycon Journal of the American Chemical Society 2002 124:5288-5290 DOI:10.1021/ja020237q PMID:11996568
- McAtee, J. J., Castle, S. L., Jin, Q., Boger, D. L. Synthesis and evaluation of vancomycin and vancomycin aglycon analogues that bear modifications in the residue 3 asparagine Bioorganic & Medicinal Chemistry Letters 2002 12:1319-1322 DOI:10.1016/s0960-894x(02)00130-0 PMID:11965380
- Berg, T., Cohen, S. B., Desharnais, J., Sonderegger, C., Maslyar, D. J., Goldberg, J., Boger, D. L., Vogt, P. K. Small-molecule antagonists of Myc/Max dimerization inhibit Myc-induced transformation of chicken embryo fibroblasts Proceedings of the National Academy of Sciences of the United States of America 2002 99:3830-3835 DOI:10.1073/pnas.062036999 PMID:11891322 PMCID:PMC122609
- Woods, C. R., Ishii, T., Wu, B., Bair, K. W., Boger, D. L. Hairpin versus extended DNA binding of a substituted beta-alanine linked polyamide Journal of the American Chemical Society 2002 124:2148-2152 DOI:10.1021/ja0122039 PMID:11878968
- Ambroise, Y., Boger, D. L. The DNA phosphate backbone is not involved in catalysis of the duocarmycin and CC-1065 DNA alkylation reaction Bioorganic & Medicinal Chemistry Letters 2002 12:303-306 DOI:10.1016/s0960-894x(01)00740-5 PMID:11814783
- Goldberg, J., Jin, Q., Ambroise, Y., Satoh, S., Desharnais, J., Capps, K., Boger, D. L. Erythropoietin mimetics derived from solution phase combinatorial libraries Journal of the American Chemical Society 2002 124:544-555 DOI:10.1021/ja0118789 PMID:11804483
- Krenitsky, P. J., Boger, D. L. Preparation of the 14-membered L,L-cycloisodityrosine subunit of RP 66453 Tetrahedron Letters 2002 43:407-410 DOI:10.1016/s0040-4039(01)02194-3
- Greasley, S. E., Marsilje, T. H., Cai, H., Baker, S., Benkovic, S. J., Boger, D. L., Wilson, I. A. Unexpected formation of an epoxide-derived multisubstrate adduct inhibitor on the active site of GAR transformylase Biochemistry 2001 40:13538-13547 DOI:10.1021/bi011482+ PMID:11695901
- Boger, D. L., Schmitt, H. W., Fink, B. E., Hedrick, M. P. Parallel synthesis and evaluation of 132 (+)-1,2,9,9a-tetrahydrocyclopropa c benz e indol-4-one (CBI) analogues of CC-1065 and the duocarmycins defining the contribution of the DNA-binding domain Journal of Organic Chemistry 2001 66:6654-6661 DOI:10.1021/jo010454u PMID:11578217
- Fedorova, I., Hashimoto, A., Fecik, R. A., Hedrick, M. P., Hanus, L. O., Boger, D. L., Rice, K. C., Basile, A. S. Behavioral evidence for the interaction of oleamide with multiple neurotransmitter systems Journal of Pharmacology and Experimental Therapeutics 2001 299:332-342 PMID:11561096
- Ellis, D. A., Wolkenberg, S. E., Boger, D. L. Metal cation complexation and activation of reversed CPyi analogues of CC-1065 and duocarmycin SA: Partitioning the effects of binding and catalysis Journal of the American Chemical Society 2001 123:9299-9306 DOI:10.1021/ja010769r PMID:11562212
- Boger, D. L.*, Hong, J. Y.* Asymmetric total synthesis of ent-(-)-roseophilin: Assignment of absolute configuration Journal of the American Chemical Society 2001 123:8515-8519 DOI:10.1021/ja011271s PMID:11525659 (* = equal contribution)
- Boger, D. L.*, Tse, W. C.* Thiazole orange as the fluorescent intercalator in a high resolution fid assay for determining DNA binding affinity and sequence selectivity of small molecules Bioorganic & Medicinal Chemistry 2001 9:2511-2518 DOI:10.1016/s0968-0896(01)00243-7 PMID:11553493 (* = equal contribution)
- Boger, D. L. Vancomycin, teicoplanin, and ramoplanin: Synthetic and mechanistic studies Medicinal Research Reviews 2001 21:356-381 DOI:10.1002/med.1014 PMID:11579438
- Mori, Y., McAtee, J. J., Rogel, O., Boger, D. L. Alternative synthesis and thermal atropisomerism of a fully functionalized DEFG ring system of teicoplanin Tetrahedron Letters 2001 42:6061-6064 DOI:10.1016/s0040-4039(01)01199-6
- Boger, D. L., Stauffer, F., Hedrick, M. P. Substituent effects within the DNA binding subunit of CBI analogues of the duocarmycins and CC-1065 Bioorganic & Medicinal Chemistry Letters 2001 11:2021-2024 DOI:10.1016/s0960-894x(01)00372-9 PMID:11454471
- Boger, D. L., Brunette, S. R., Garbaccio, R. M. Synthesis and evaluation of a series of C3-substituted CBI analogues of CC-1065 and the duocarmycins Journal of Organic Chemistry 2001 66:5163-5173 DOI:10.1021/jo010309g PMID:11463270
- Boger, D. L., Fink, B. E., Brunette, S. R., Tse, W. C., Hedrick, M. P. A simple, high-resolution method for establishing DNA binding affinity and sequence selectivity Journal of the American Chemical Society 2001 123:5878-5891 DOI:10.1021/ja010041a PMID:11414820
- Boger, D. L., Miyauchi, H., Hedrick, M. P. Alpha-Keto heterocycle inhibitors of fatty acid amide hydrolase: carbonyl group modification and alpha-substitution Bioorganic & Medicinal Chemistry Letters 2001 11:1517-1520 DOI:10.1016/s0960-894x(01)00211-6 PMID:11412972
- Boger, D. L. Recent advances in bioorganic and medicinal chemistry. Preface. Bioorganic & Medicinal Chemistry Letters 2001 11:ix DOI:10.1016/s0960-894x(01)00337-7
- Boger, D. L., Ichikawa, S., Zhong, W. Total synthesis of fostriecin (CI-920) Journal of the American Chemical Society 2001 123:4161-4167 DOI:10.1021/ja010195q PMID:11457179
- Boger, D. L., Hughes, T. V., Hedrick, M. P. Synthesis, chemical properties, and biological evaluation of CC-1065 and duocarmycin analogues incorporating the 5-methoxycarbonyl-1,2,9,9a-tetrahydrocyclopropa c benz e indol-4-one alkylation subunit Journal of Organic Chemistry 2001 66:2207-2216 DOI:10.1021/jo001772g PMID:11281757
- Boger, D. L., Kim, S. H., Mori, Y., Weng, J. H., Rogel, O., Castle, S. L., McAtee, J. J. First and second generation total synthesis of the teicoplanin aglycon Journal of the American Chemical Society 2001 123:1862-1871 DOI:10.1021/ja003835i PMID:11456806
- Boger, D. L.*, Goldberg, J.* Cytokine receptor dimerization and activation: prospects for small molecule agonists Bioorganic & Medicinal Chemistry 2001 9:557-562 DOI:10.1016/s0968-0896(00)00276-5 PMID:11310589 (* = equal contribution)
- Boger, D. L.*, Goldberg, J.*, Silletti, S., Kessler, T., Cheresh, D. A. Identification of a novel class of small-molecule antiangiogenic agents through the screening of combinatorial libraries which function by inhibiting the binding and localization of proteinase MMP2 to integrin alpha(V)beta(3) Journal of the American Chemical Society 2001 123:1280-1288 DOI:10.1021/ja003579+ PMID:11456699 (* = equal contribution)
- Boger, D. L., Ichikawa, S., Tse, W. C., Hedrick, M. P., Jin, Q. Total syntheses of thiocoraline and be-22179 and assessment of their DNA binding and biological properties Journal of the American Chemical Society 2001 123:561-568 DOI:10.1021/ja003602r PMID:11456568
- Silletti, S., Kessler, T., Goldberg, J., Boger, D. L., Cheresh, D. A. Disruption of matrix metalloproteinase 2 binding to integrin alpha(v)beta(3) by an organic molecule inhibits angiogenesis and tumor growth in vivo Proceedings of the National Academy of Sciences of the United States of America 2001 98:119-124 DOI:10.1073/pnas.011343298 PMID:11134507 PMCID:PMC14554
- Boger, D. L.*, Wolkenberg, S. E.* Total synthesis of Amaryllidaceae alkaloids utilizing sequential intramolecular heterocyclic azadiene Diels-Alder reactions of an unsymmetrical 1,2,4,5-tetrazine Journal of Organic Chemistry 2000 65:9120-9124 DOI:10.1021/jo0012546 PMID:11149859 (* = equal contribution)
- Boger, D. L., Ichikawa, S., Jiang, H. J. Total synthesis of the rubrolone aglycon Journal of the American Chemical Society 2000 122:12169-12173 DOI:10.1021/ja002997b
- Boger, D. L., Fecik, R. A., Patterson, J. E., Miyauchi, H., Patricelli, M. P., Cravatt, B. F. Fatty acid amide hydrolase substrate specificity Bioorganic & Medicinal Chemistry Letters 2000 10:2613-2616 DOI:10.1016/s0960-894x(00)00528-x PMID:11128635
- Boger, D. L., Aquila, B. M., Tse, W. C., Searcey, M. Synthesis and evaluation of a novel bleomycin A(2) analogue: Continuing assessment of the linker domain Tetrahedron Letters 2000 41:9493-9498 DOI:10.1016/s0040-4039(00)01633-6
- Boger, D. L., Weng, J. H., Miyazaki, S., McAtee, J. J., Castle, S. L., Kim, S. H., Mori, Y., Rogel, O., Strittmatter, H., Jin, Q. Thermal atropisomerism of teicoplanin aglycon derivatives: Preparation of the P,P,P and M,P,P atropisomers of the teicoplanin aglycon via selective equilibration of the DE ring system Journal of the American Chemical Society 2000 122:10047-10055 DOI:10.1021/ja002376i
- Boger, D. L., Lee, R. J., Bounaud, P. Y., Meier, P. Asymmetric synthesis of orthogonally protected L-threo-beta-hydroxyasparagine Journal of Organic Chemistry 2000 65:6770-6772 DOI:10.1021/jo000628s PMID:11052134
- Boger, D. L., Lee, J. K. Development of a solution-phase synthesis of minor groove binding bis-intercalators based on triostin A suitable for combinatorial synthesis Journal of Organic Chemistry 2000 65:5996-6000 DOI:10.1021/jo000382r PMID:10987932
- Boger, D. L., Chen, Y., Foster, C. A. Synthesis and evaluation of aza HUN-7293 Bioorganic & Medicinal Chemistry Letters 2000 10:1741-1744 DOI:10.1016/s0960-894x(00)00336-x PMID:10937737
- Boger, D. L., Kim, S. H., Miyazaki, S., Strittmatter, H., Weng, J. H., Mori, Y., Rogel, O., Castle, S. L., McAtee, J. J. Total synthesis of the teicoplanin aglycon Journal of the American Chemical Society 2000 122:7416-7417 DOI:10.1021/ja001663j
- Boger, D. L., Dechantsreiter, M. A., Ishii, T., Fink, B. E., Hedrick, M. P. Assessment of solution-phase positional scanning libraries based on distamycin A for the discovery of new DNA binding agents Bioorganic & Medicinal Chemistry 2000 8:2049-2057 DOI:10.1016/s0968-0896(00)00137-1 PMID:11003149
- Smith, J. A., Bifulco, G., Case, D. A., Boger, D. L., Gomez-Paloma, L., Chazin, W. J. The structural basis for in situ activation of DNA alkylation by duocarmycin sa Journal of Molecular Biology 2000 300:1195-1204 DOI:10.1006/jmbi.2000.3887 PMID:10903864
- Boger, D. L., Fink, B. E., Hedrick, M. P. Total synthesis of distamycin A and 2640 analogues: A solution-phase combinatorial approach to the discovery of new, bioactive DNA binding agents and development of a rapid, high-throughput screen for determining relative DNA binding affinity or DNA binding sequence selectivity Journal of the American Chemical Society 2000 122:6382-6394 DOI:10.1021/ja994192d
- Boger, D. L.*, Wolkenberg, S. E.*, Boyce, C. W. A new method of in situ activation for a novel class of DNA alkylating agents: tunable metal cation complexation and activation Journal of the American Chemical Society 2000 122:6325-6326 DOI:10.1021/ja000653f (* = equal contribution)
- Boger, D. L., Marsilje, T. H., Castro, R. A., Hedrick, M. P., Jin, Q., Baker, S. J., Shim, J. H., Benkovic, S. J. Design, synthesis, and biological evaluation of fluoronitrophenyl substituted folate analogues as potential inhibitors of GAR transformylase and AICAR transformylase Bioorganic & Medicinal Chemistry Letters 2000 10:1471-1475 DOI:10.1016/s0960-894x(00)00271-7 PMID:10888335
- Boger, D. L.*, Boyce, C. W.* Selective metal cation activation of a DNA alkylating agent: Synthesis and evaluation of methyl 1,2,9,9a-Tetrahydrocyclopropa c pyrido 3,2-e indol-4-one-7-carboxylate (CPyl) Journal of Organic Chemistry 2000 65:4088-4100 DOI:10.1021/jo000177b PMID:10866626 (* = equal contribution)
- Boger, D. L., Santillan, A., Searcey, M., Brunette, S. R., Wolkenberg, S. E., Hedrick, M. P., Jin, Q. Synthesis and evaluation of 1,2,8, 8a-Tetrahydrocyclopropa[c]pyrrolo[3,2-e]indol-4(5H)-one, the parent alkylation subunit of CC-1065 and the duocarmycins: impact of the alkylation subunit substituents and its implications for DNA alkylation catalysis Journal of Organic Chemistry 2000 65:4101-4111 DOI:10.1021/jo000297j PMID:10866627
- Boger, D. L., Fink, B. E., Hedrick, M. P. A new class of highly cytotoxic diketopiperazines Bioorganic & Medicinal Chemistry Letters 2000 10:1019-1020 DOI:10.1016/s0960-894x(00)00152-9 PMID:10843206
- Boger, D. L., Sato, H., Lerner, A. E., Hedrick, M. P., Fecik, R. A., Miyauchi, H., Wilkie, G. D., Austin, B. J., Patricelli, M. P., Cravatt, B. F. Exceptionally potent inhibitors of fatty acid amide hydrolase: the enzyme responsible for degradation of endogenous oleamide and anandamide Proceedings of the National Academy of Sciences of the United States of America 2000 97:5044-5049 DOI:10.1073/pnas.97.10.5044 PMID:10805767 PMCID:PMC25778
- Boger, D. L., Labroli, M. A., Marsilje, T. H., Jin, Q., Hedrick, M. P., Baker, S. J., Shim, J. H., Benkovic, S. J. Conformationally restricted analogues designed for selective inhibition of GAR Tfase versus thymidylate synthase or dihydrofolate reductase Bioorganic & Medicinal Chemistry 2000 8:1075-1086 DOI:10.1016/s0968-0896(00)00051-1 PMID:10882019
- Boger, D. L.*, Soenen, D. R.*, Boyce, C. W., Hedrick, M. P., Jin, Q. Total synthesis of ningalin B utilizing a heterocyclic azadiene Diels-Alder reaction and discovery of a new class of potent multidrug resistant (MDR) reversal agents Journal of Organic Chemistry 2000 65:2479-2483 DOI:10.1021/jo9916535 PMID:10789460 (* = equal contribution)
- Boger, D. L., Ichikawa, S. Total syntheses of thiocoraline and be-22179: Establishment of relative and absolute stereochemistry Journal of the American Chemical Society 2000 122:2956-2957 DOI:10.1021/ja0001660
- Boger, D. L., Lee, J. K., Goldberg, J., Jin, Q. Two comparisons of the performance of positional scanning and deletion synthesis for the identification of active constituents in mixture combinatorial libraries Journal of Organic Chemistry 2000 65:1467-1474 DOI:10.1021/jo9916481 PMID:10814111
- Boger, D. L., Searcey, M., Tse, W. C., Jin, Q. Bifunctional alkylating agents derived from duocarmycin SA: Potent antitumor activity with altered sequence selectivity Bioorganic & Medicinal Chemistry Letters 2000 10:495-498 DOI:10.1016/s0960-894x(00)00042-1 PMID:10743956
- Boger, D. L.*, Goldberg, J.*, Satoh, S., Ambroise, Y., Cohen, S. B., Vogt, P. K. Non-amide-based combinatorial libraries derived from N-BOC-iminodiacetic acid: solution-phase synthesis of piperazinone libraries with activity against LEF-1/β-catenin-mediated transcription Helvetica Chimica Acta 2000 83:1825-1845 DOI:10.1002/1522-2675(20000809)83:8<1825::aid-hlca1825>3.0.co;2-4 (* = equal contribution)
- Greasley, S. E., Yamashita, M. M., Cai, H., Benkovic, S. J., Boger, D. L., Wilson, I. A. New insights into inhibitor design from the crystal structure and NMR studies of escherichia coli GAR and 10-formyl-5,8,10-trideazafolic acid Biochemistry 1999 38:16783-16793 DOI:10.1021/bi991888a PMID:10606510
- Boger, D. L., Ledeboer, M. W., Kume, M., Searcey, M., Jin, Q. Total synthesis and comparative evaluation of luzopeptin A-C and quinoxapeptin A-C Journal of the American Chemical Society 1999 121:11375-11383 DOI:10.1021/ja993019e
- Boger, D. L.*, Garbaccio, R. M.* Shape-dependent catalysis: Insights into the source of catalysis for the CC-1065 and duocarmycin DNA alkylation reaction Accounts of Chemical Research 1999 32:1043-1052 DOI:10.1021/ar9800946 (* = equal contribution)
- Baraldi, P. G., Cacciari, B., Romagnoli, R., Spalluto, G., Boyce, C. W., Boger, D. L. Resolution of a CPzl precursor, synthesis and biological evaluation of (+) and (-)-NBoc-CPzl: a further validation of the relationship between chemical solvolytic stability and cytotoxicity Bioorganic & Medicinal Chemistry Letters 1999 9:3087-3092 DOI:10.1016/s0960-894x(99)00533-8 PMID:10560730
- Boger, D. L.*, Garbaccio, R. M.* A novel class of CC-1065 and duocarmycin analogues subject to mitomycin-related reductive activation Journal of Organic Chemistry 1999 64:8350-8362 DOI:10.1021/jo991301y PMID:11674758 (* = equal contribution)
- Boger, D. L., Jiang, W. Q., Goldberg, J. Convergent solution-phase combinatorial synthesis with multiplication of diversity through rigid biaryl and diarylacetylene couplings Journal of Organic Chemistry 1999 64:7094-7100 DOI:10.1021/jo990639p
- Boger, D. L.*, Garbaccio, R. M.* Are the duocarmycin and CC-1065 DNA alkylation reactions acid-catalyzed? Solvolysis pH-rate profiles suggest they are not Journal of Organic Chemistry 1999 64:5666-5669 DOI:10.1021/jo990762g PMID:11674637 (* = equal contribution)
- Boger, D. L., Santillan, A., Searcey, M., Jin, Q. Synthesis and evaluation of duocarmycin and CC-1065 analogues containing modifications in the subunit linking amide Journal of Organic Chemistry 1999 64:5241-5244 DOI:10.1021/jo990452y
- Boger, D. L., Keim, H., Oberhauser, B., Schreiner, E. P., Foster, C. A. Total synthesis of HUN-7293 Journal of the American Chemical Society 1999 121:6197-6205 DOI:10.1021/ja990918u
- Schnell, J. R., Ketchem, R. R., Boger, D. L., Chazin, W. J. Binding-induced activation of DNA alkylation by duocarmycin SA: Insights from the structure of an indole derivative-DNA adduct Journal of the American Chemical Society 1999 121:5645-5652 DOI:10.1021/ja983556j
- Boger, D. L., Sato, H., Lerner, A. E., Guan, X. J., Gilula, N. B. Arachidonic acid amide inhibitors of gap junction cell-cell communication Bioorganic & Medicinal Chemistry Letters 1999 9:1151-1154 DOI:10.1016/s0960-894x(99)00148-1 PMID:10328303
- Boger, D. L., Miyazaki, S., Kim, S. H., Wu, J. H., Loiseleur, O., Castle, S. L. Diastereoselective total synthesis of the vancomycin aglycon with ordered atropisomer equilibrations Journal of the American Chemical Society 1999 121:3226-3227 DOI:10.1021/ja990189i
- Boger, D. L.*, Goldberg, J.*, Andersson, C. M. Solution phase combinatorial synthesis of biaryl libraries employing heterogeneous conditions for catalysis and isolation with size exclusion chromatography for purification Journal of Organic Chemistry 1999 64:2422-2427 DOI:10.1021/jo982234v (* = equal contribution)
- Boger, D. L.*, Hong, J.*, Hikota, M., Ishida, M. Total synthesis of phomazarin Journal of the American Chemical Society 1999 121:2471-2477 DOI:10.1021/ja983631q (* = equal contribution)
- Wilcox, B. J., Ritenour-Rodgers, K. J., Asser, A. S., Baumgart, L. E., Baumgart, M. A., Boger, D. L., DeBlassio, J. L., deLong, M. A., Glufke, U., Henz, M. E., King, L., Merkler, K. A., et al. N-acylglycine amidation: implications for the biosynthesis of fatty acid primary amides Biochemistry 1999 38:3235-3245 DOI:10.1021/bi982255j PMID:10079066
- Boger, D. L., Ledeboer, M. W., Kume, M. Total synthesis of luzopeptins A-C Journal of the American Chemical Society 1999 121:1098-1099 DOI:10.1021/ja983925b
- Boger, D. L., Saionz, K. W. DNA binding properties of key sandramycin analogues: systematic examination of the intercalation chromophore Bioorganic & Medicinal Chemistry 1999 7:315-321 DOI:10.1016/s0968-0896(98)00206-5 PMID:10218823
- Boger, D. L., Sato, H., Lerner, A. E., Austin, B. J., Patterson, J. E., Patricelli, M. P., Cravatt, B. F. Trifluoromethyl ketone inhibitors of fatty acid amide hydrolase: a probe of structural and conformational features contributing to inhibition Bioorganic & Medicinal Chemistry Letters 1999 9:265-270 DOI:10.1016/s0960-894x(98)00734-3 PMID:10021942
- Boger, D. L.*, Boyce, C. W.*, Labroli, M. A., Sehon, C. A., Jin, Q. Total syntheses of ningalin A, lamellarin O, lukianol A, and permethyl storniamide A utilizing heterocyclic azadiene Diels-Alder reactions Journal of the American Chemical Society 1999 121:54-62 DOI:10.1021/ja982078+ (* = equal contribution)
- Boger, D. L.*, Castle, S. L.*, Miyazaki, S., Wu, J. H., Beresis, R. T., Loiseleur, O. Vancomycin CD and DE macrocyclization and atropisomerism studies Journal of Organic Chemistry 1999 64:70-80 DOI:10.1021/jo980880o PMID:11674087 (* = equal contribution)
- Boger, D. L., Cai, H. Bleomycin: synthetic and mechanistic studies Angewandte Chemie-International Edition 1999 38:448-476 DOI:10.1002/(sici)1521-3773(19990215)38:4<448::aid-anie448>3.0.co;2-w
- Boger, D. L.*, Boyce, C. W.*, Garbaccio, R. M., Searcey, M., Jin, Q. CBI prodrug analogs of CC-1065 and the duocarmycins Synthesis-Stuttgart 1999 1505-1509 (* = equal contribution)
- Boger, D. L., Ledeboer, M. W., Kume, M., Jin, Q. Total synthesis of quinoxapeptin A-C: Establishment of absolute stereochemistry Angewandte Chemie-International Edition 1999 38:2424-2426 DOI:10.1002/(sici)1521-3773(19990816)38:16<2424::aid-anie2424>3.0.co;2-9 PMID:10458810
- Boger, D. L., Miyazaki, S., Kim, S. H., Wu, J. H., Castle, S. L., Loiseleur, O., Jin, Q. Total synthesis of the vancomycin aglycon Journal of the American Chemical Society 1999 121:10004-10011 DOI:10.1021/ja992577q
- Boger, D. L., Santillan, A., Searcey, M., Jin, Q. Critical role of the linking amide in CC-1065 and the duocarmycins: implications on the source of DNA alkylation catalysis Journal of the American Chemical Society 1998 120:11554-11557 DOI:10.1021/ja9818093
- Boger, D. L., Turnbull, P. Synthesis and evaluation of a carbocyclic analogue of the CC-1065 and duocarmycin alkylation subunits: role of the vinylogous amide and implications on DNA alkylation catalysis Journal of Organic Chemistry 1998 63:8004-8011 DOI:10.1021/jo981698q
- Boger, D. L., Ramsey, T. M., Cai, H., Hoehn, S. T., Stubbe, J. A. A systematic evaluation of the bleomycin A(2) L-threonine side chain: its role in preorganization of a compact conformation implicated in sequence-selective DNA cleavage Journal of the American Chemical Society 1998 120:9139-9148 DOI:10.1021/ja9816638
- Boger, D. L., Ramsey, T. M., Cai, H., Hoehn, S. T., Stubbe, J. Definition of the effect and role of the bleomycin A(2) valerate substituents: preorganization of a rigid, compact conformation implicated in sequence-selective DNA cleavage Journal of the American Chemical Society 1998 120:9149-9158 DOI:10.1021/ja9816640
- Boger, D. L., Miyazaki, S., Loiseleur, O., Beresis, R. T., Castle, S. L., Wu, J. H., Jin, Q. Thermal atropisomerism of aglucovancomycin derivatives: preparation of (M,M,M)- and (P,M,M)-aglucovancomycins Journal of the American Chemical Society 1998 120:8920-8926 DOI:10.1021/ja981928i
- Boger, D. L. Combinatorial chemistry Bioorganic & Medicinal Chemistry Letters 1998 8:VII-VII DOI:10.1016/s0960-894x(98)90007-5
- Boger, D. L., Ducray, P., Chai, W. Y., Jiang, W. Q., Goldberg, J. Higher order iminodiacetic acid libraries for probing protein-protein interactions Bioorganic & Medicinal Chemistry Letters 1998 8:2339-2344 DOI:10.1016/s0960-894x(98)00423-5 PMID:9873538
- Boger, D. L., Schaum, R. P., Garbaccio, R. M. Regioselective inverse electron demand Diels-Alder reactions of N-acyl 6-amino-3-(methylthio)-1,2,4,5-tetrazines Journal of Organic Chemistry 1998 63:6329-6337 DOI:10.1021/jo980795g PMID:11672266
- Boger, D. L., Schule, G. Synthesis of acyclic precursors to (3S,4S)-4-hydroxy-2,3,4,5-tetrahydro-pyridazine-3-carboxylic acid and incorporation into a luzopeptin/quinoxapeptin dipeptide Journal of Organic Chemistry 1998 63:6421-6424 DOI:10.1021/jo980765d PMID:11672282
- Boger, D. L. Heterocyclic and acyclic azadiene Diels-Alder reactions: total synthesis of nothapodytine B Journal of Heterocyclic Chemistry 1998 35:1003-1011 DOI:10.1002/jhet.5570350502
- Boger, D. L.*, Goldberg, J.*, Jiang, W. Q., Chai, W. Y., Ducray, P., Lee, J. K., Ozer, R. S., Andersson, C. M. Higher order iminodiacetic acid libraries for probing protein-protein interactions Bioorganic & Medicinal Chemistry 1998 6:1347-1378 DOI:10.1016/s0968-0896(98)00128-x PMID:9784874 (* = equal contribution)
- Boger, D. L., Henriksen, S. J., Cravatt, B. F. Oleamide: an endogenous sleep-inducing lipid and prototypical member of a new class of biological signaling molecules Current Pharmaceutical Design 1998 4:303-314 PMID:10197045
- Boger, D. L., Chai, W. Y., Jin, Q. Multistep convergent solution-phase combinatorial synthesis and deletion synthesis deconvolution Journal of the American Chemical Society 1998 120:7220-7225 DOI:10.1021/ja9803557
- Boger, D. L., Kochanny, M. J., Cai, H., Wyatt, D., Kitos, P. A., Warren, M. S., Ramcharan, J., Gooljarsingh, L. T., Benkovic, S. J. Design, synthesis, and evaluation of potential GAR and AICAR transformylase inhibitors Bioorganic & Medicinal Chemistry 1998 6:643-659 DOI:10.1016/s0968-0896(98)00040-6 PMID:9681131
- Boger, D. L.*, Patterson, J. E.*, Guan, X., Cravatt, B. F., Lerner, R. A., Gilula, N. B. Chemical requirements for inhibition of gap junction communication by the biologically active lipid oleamide Proceedings of the National Academy of Sciences of the United States of America 1998 95:4810-4815 DOI:10.1073/pnas.95.9.4810 PMID:9560184 PMCID:PMC20169 (* = equal contribution)
- Boger, D. L., Chai, W. Y. Solution-phase combinatorial synthesis: Convergent multiplication of diversity via the olefin metathesis reaction Tetrahedron 1998 54:3955-3970 DOI:10.1016/s0040-4020(98)00128-8
- Boger, D. L.*, Boyce, C. W.*, Garbaccio, R. M., Searcey, M. Synthesis of CC-1065 and duocarmycin analogs via intramolecular aryl radical cyclization of a tethered vinyl chloride Tetrahedron Letters 1998 39:2227-2230 DOI:10.1016/s0040-4039(98)00232-9 (* = equal contribution)
- Boger, D. L.*, Patterson, J. E.*, Jin, Q. Structural requirements for 5-HT2A and 5-HT1A serotonin receptor potentiation by the biologically active lipid oleamide Proceedings of the National Academy of Sciences of the United States of America 1998 95:4102-4107 DOI:10.1073/pnas.95.8.4102 PMID:9539697 (* = equal contribution)
- Boger, D. L., Beresis, R. T., Loiseleur, O., Wu, J. H., Castle, S. L. Synthesis of the vancomycin CDE ring system Bioorganic & Medicinal Chemistry Letters 1998 8:721-724 DOI:10.1016/s0960-894x(98)00110-3 PMID:9871529
- Wu, W., Vanderwall, D. E., Teramoto, S., Lui, S. M., Hoehn, S. T., Tang, X. J., Turner, C. J., Boger, D. L., Kozarich, J. W., Stubbe, J. NMR studies of Co.deglycoBleomycin A2 green and its complex with d(CCAGGCCTGG) Journal of the American Chemical Society 1998 120:2239-2250 DOI:10.1021/ja972125i
- Patricelli, M. P., Patterson, J. E., Boger, D. L., Cravatt, B. F. An endogenous sleep-inducing compound is a novel competitive inhibitor of fatty acid amide hydrolase Bioorganic & Medicinal Chemistry Letters 1998 8:613-618 DOI:10.1016/s0960-894x(98)00073-0 PMID:9871570
- Boger, D. L.*, Hong, J. Y.* Total synthesis of nothapodytine B and (-)-mappicine Journal of the American Chemical Society 1998 120:1218-1222 DOI:10.1021/ja973007y (* = equal contribution)
- Boger, D. L., Ramsey, T. M., Cai, H., Hoehn, S. T., Kozarich, J. W., Stubbe, J. Assessment of the role of the bleomycin A(2) pyrimidoblamic acid C4 amino group Journal of the American Chemical Society 1998 120:53-65 DOI:10.1021/ja971889v
- Boger, D. L., Chen, J. H., Saionz, K. W., Jin, Q. Synthesis of key sandramycin analogs: Systematic examination of the intercalation chromophore Bioorganic & Medicinal Chemistry 1998 6:85-102 DOI:10.1016/s0968-0896(97)10014-1 PMID:9502108
- Boger, D. L., Searcey, M. The first synthesis of a daphnane diterpene: the enantiocontrolled total synthesis of (+)-resiniferatoxin Chemtracts 1998 11:647-651
- Guan, X. J., Cravatt, B. F., Ehring, C. R., Hall, J. E., Boger, D. L., Lerner, R. A., Gilula, N. B. The sleep-inducing lipid oleamide deconvolutes gap junction communication and calcium wave transmission in glial cells Journal of Cell Biology 1997 139:1785-1792 DOI:10.1083/jcb.139.7.1785 PMID:9412472 PMCID:PMC2132638
- Boger, D. L., Loiseleur, O., Castle, S. L., Beresis, R. T., Wu, J. H. Thermal atropisomerism of fully functionalized vancomycin CD, DE, and CDE ring systems Bioorganic & Medicinal Chemistry Letters 1997 7:3199-3202 DOI:10.1016/s0960-894x(97)10182-2
- Boger, D. L.*, Garbaccio, R. M.*, Jin, Q. Synthesis and evaluation of CC-1065 and duocarmycin analogues incorporating the iso-CI and iso-CBI alkylation subunits: impact of relocation of the C-4 carbonyl Journal of Organic Chemistry 1997 62:8875-8891 DOI:10.1021/jo971686p (* = equal contribution)
- Eis, P. S., Smith, J. A., Rydzewski, J. M., Case, D. A., Boger, D. L., Chazin, W. J. High resolution solution structure of a DNA duplex alkylated by the antitumor agent duocarmycin SA Journal of Molecular Biology 1997 272:237-252 DOI:10.1006/jmbi.1997.1223 PMID:9299351
- Boger, D. L.*, Haynes, N. E.*, Kitos, P. A., Warren, M. S., Ramcharan, J., Marolewski, A. E., Benkovic, S. J. 10-formyl-5,8,10-trideazafolic acid (10-formyl-TDAF): a potent inhibitor of glycinamide ribonucleotide transformylase Bioorganic & Medicinal Chemistry 1997 5:1817-1830 DOI:10.1016/s0968-0896(97)00120-x PMID:9354237 (* = equal contribution)
- Boger, D. L.*, Haynes, N. E.*, Warren, M. S., Ramcharan, J., Marolewski, A. E., Kitos, P. A., Benkovic, S. J. Abenzyl 10-formyl-trideazafolic acid (abenzyl 10-formyl-TDAF): an effective inhibitor of glycinamide ribonucleotide transformylase Bioorganic & Medicinal Chemistry 1997 5:1847-1852 DOI:10.1016/s0968-0896(97)00123-5 PMID:9354240 (* = equal contribution)
- Boger, D. L.*, Haynes, N. E.*, Warren, M. S., Ramcharan, J., Kitos, P. A., Benkovic, S. J. Functionalized analogues of 5,8,10-trideazafolate: Development of an enzyme-assembled tight binding inhibitor of GAR Tfase and a potential irreversible inhibitor of AICAR Tfase Bioorganic & Medicinal Chemistry 1997 5:1839-1846 DOI:10.1016/s0968-0896(97)00122-3 PMID:9354239 (* = equal contribution)
- Boger, D. L.*, Haynes, N. E.*, Warren, M. S., Ramcharan, J., Kitos, P. A., Benkovic, S. J. Multisubstrate analogue based on 5,8,10-trideazafolate Bioorganic & Medicinal Chemistry 1997 5:1853-1857 DOI:10.1016/s0968-0896(97)00124-7 PMID:9354241 (* = equal contribution)
- Boger, D. L., Turnbull, P. Synthesis and evaluation of CC-1065 and duocarmycin analogs incorporating the 1,2,3,4,11,11a-hexahydrocyclopropa c naphtho 2,1-b azepin-6-one (CNA) alkylation subunit: Structural features that govern reactivity and reaction regioselectivity Journal of Organic Chemistry 1997 62:5849-5863 DOI:10.1021/jo9707085
- Boger, D. L., Teramoto, S., Cai, H. N-methyl threonine analogues of deglycobleomycin A(2): Synthesis and evaluation Bioorganic & Medicinal Chemistry 1997 5:1577-1589 DOI:10.1016/s0968-0896(97)00107-7 PMID:9313863
- Boger, D. L.*, Ozer, R. S.*, Andersson, C. M. Generation of targeted C-2-symmetrical compound libraries by solution-phase combinatorial chemistry Bioorganic & Medicinal Chemistry Letters 1997 7:1903-1908 DOI:10.1016/s0960-894x(97)00330-2 (* = equal contribution)
- Boger, D. L., Borzilleri, R. M., Nukui, S., Beresis, R. T. Synthesis of the vancomycin CD and DE ring systems Journal of Organic Chemistry 1997 62:4721-4736 DOI:10.1021/jo970560p
- Sakya, S. M., Groskopf, K. K., Boger, D. L. Preparation and inverse electron demand diels-alder reactions of 3-methoxy-6-methylthio-1,2,4,5-tetrazine Tetrahedron Letters 1997 38:3805-3808 DOI:10.1016/s0040-4039(97)00751-x
- Boger, D. L., Hertzog, D. L., Bollinger, B., Johnson, D. S., Cai, H., Goldberg, J., Turnbull, P. Duocarmycin SA shortened, simplified, and extended agents: A systematic examination of the role of the DNA binding subunit Journal of the American Chemical Society 1997 119:4977-4986 DOI:10.1021/ja9637208
- Boger, D. L., Bollinger, B., Hertzog, D. L., Johnson, D. S., Cai, H., Mesini, P., Garbaccio, R. M., Jin, Q., Kitos, P. A. Reversed and sandwiched analogs of duocarmycin SA: Establishment of the origin of the sequence-selective alkylation of DNA and new insights into the source of catalysis Journal of the American Chemical Society 1997 119:4987-4998 DOI:10.1021/ja9637210
- Boger, D. L., McKie, J. A., Boyce, C. W. Asymmetric synthesis of the CBI alkylation subunit of the CC-1065 and duocarmycin analogs Synlett 1997 515-517
- Boger, D. L.*, Boyce, C. W.*, Garbaccio, R. M., Goldberg, J. A. CC-1065 and the duocarmycins: Synthetic studies Chemical Reviews 1997 97:787-828 DOI:10.1021/cr960095g PMID:11848889 (* = equal contribution)
- Boger, D. L., Chen, J. H. An exceptionally potent analog of sandramycin Bioorganic & Medicinal Chemistry Letters 1997 7:919-922 DOI:10.1016/s0960-894x(97)00129-7
- Boger, D. L.*, Zhou, J. C.*, Borzilleri, R. M., Nukui, S., Castle, S. L. Synthesis of (9R,12S)- and (9S,12S)-cycloisodityrosine and their N-methyl derivatives Journal of Organic Chemistry 1997 62:2054-2069 DOI:10.1021/jo961346o PMID:11671510 (* = equal contribution)
- Boger, D. L., Hikota, M., Lewis, B. M. Determination of the relative and absolute stereochemistry of fostriecin (CL-920) Journal of Organic Chemistry 1997 62:1748-1753 DOI:10.1021/jo962166h
- Boger, D. L., Chai, W. Y., Ozer, R. S., Andersson, C. M. Solution-phase combinatorial synthesis via the olefin metathesis reaction Bioorganic & Medicinal Chemistry Letters 1997 7:463-468 DOI:10.1016/s0960-894x(97)00043-7
- Boger, D. L., Han, N. H. CC-1065/duocarmycin and bleomycin A(2) hybrid agents: lack of enhancement of DNA alkylation by attachment to noncomplementary DNA binding subunits Bioorganic & Medicinal Chemistry 1997 5:233-243 DOI:10.1016/s0968-0896(96)00237-4 PMID:9061188
- Boger, D. L.*, Garbaccio, R. M.* Catalysis of the CC-1065 and duocarmycin DNA alkylation reaction: DNA binding induced conformational change in the agent results in activation Bioorganic & Medicinal Chemistry 1997 5:263-276 DOI:10.1016/s0968-0896(96)00238-6 PMID:9061191 (* = equal contribution)
- Boger, D. L.*, Boyce, C. W.*, Johnson, D. S. pH dependence of the rate of DNA alkylation for (+)-duocarmycin SA and (+)-CCBI-TMI Bioorganic & Medicinal Chemistry Letters 1997 7:233-238 DOI:10.1016/s0960-894x(96)00605-1 (* = equal contribution)
- Boger, D. L., McKie, J. A., Nishi, T., Ogiku, T. Total synthesis of (+)-duocarmycin A, epi-(+)-duocarmycin A and their unnatural enantiomers: assessment of chemical and biological properties Journal of the American Chemical Society 1997 119:311-325 DOI:10.1021/ja962431g
- Boger, D. L. Applications of free radicals in organic synthesis Israel Journal of Chemistry 1997 37:119-129
- Boger, D. L.*, Haynes, N. E.*, Warren, M. S., Gooljarsingh, L. T., Ramcharan, J., Kitos, P. A., Benkovic, S. J. Functionalized analogues of 5,8,10-trideazafolate as potential inhibitors of gar tfase or aicar tfase Bioorganic & Medicinal Chemistry 1997 5:1831-1838 DOI:10.1016/s0968-0896(97)00121-1 PMID:9354238 (* = equal contribution)
- Boger, D. L.*, Cai, H.* Solution structures of Co·Bleomycin A2 green and its complex with d(CCAGGCCTGG)2 Chemtracts 1997 10:497-502 (* = equal contribution)
- Cravatt, B. F., Giang, D. K., Mayfield, S. P., Boger, D. L., Lerner, R. A., Gilula, N. B. Molecular characterization of an enzyme that degrades neuromodulatory fatty-acid amides Nature 1996 384:83-87 DOI:10.1038/384083a0 PMID:8900284
- Boger, D. L.*, Zhou, J. C.* Key analogues of the tetrapeptide subunit of RA-VII and deoxybouvardin Bioorganic & Medicinal Chemistry 1996 4:1597-1603 DOI:10.1016/0968-0896(96)00151-4 PMID:8931929 (* = equal contribution)
- Boger, D. L., Jenkins, T. J. Synthesis, X-ray structure, and properties of fluorocyclopropane analogs of the duocarmycins incorporating the 9,9-difluoro-1,2,9,9a-tetrahydrocyclopropa c benzo e indol-4-one (F2CBI) alkylation subunit Journal of the American Chemical Society 1996 118:8860-8870 DOI:10.1021/ja961888n
- Boger, D. L., Bollinger, B., Johnson, D. S. Examination of the role of the duocarmycin SA methoxy substituents: Identification of the minimum, fully potent DNA binding subunit Bioorganic & Medicinal Chemistry Letters 1996 6:2207-2210 DOI:10.1016/0960-894x(96)00401-5
- Boger, D. L. Azadiene Diels-Alder reactions: scope and applications. Total synthesis of natural and ent-fredericamycin A Journal of Heterocyclic Chemistry 1996 33:1519-1531 DOI:10.1002/jhet.5570330508
- Boger, D. L.*, Goldberg, J.*, McKie, J. A. A comparative study of the solvolysis reactivity, regioselectivity, and stereochemistry of the duocarmycin A and SA alkylation subunits Bioorganic & Medicinal Chemistry Letters 1996 6:1955-1960 DOI:10.1016/0960-894x(96)00346-0 (* = equal contribution)
- Boger, D. L.*, Johnson, D. S.* CC-1065 and the duocarmycins: understanding their biological function through mechanistic studies Angewandte Chemie-International Edition 1996 35:1438-1474 DOI:10.1002/anie.199614381 (* = equal contribution)
- Boger, D. L., Han, N. H., Tarby, C. M., Boyce, C. W., Cai, H., Jin, Q., Kitos, P. A. Synthesis, chemical properties, and preliminary evaluation of substituted CBI analogs of CC-1065 and the duocarmycins incorporating the 7-cyano-1,2,9,9a-tetrahydrocyclopropa c benz e indol-4-one alkylation subunit: Hammett quantitation of the magnitude of electronic effects on functional reactivity Journal of Organic Chemistry 1996 61:4894-4912 DOI:10.1021/jo9605298
- Patterson, J. E., Ollmann, I. R., Cravatt, B. F., Boger, D. L., Wong, C. H., Lerner, R. A. Inhibition of oleamide hydrolase catalyzed hydrolysis of the endogenous sleep-inducing lipid cis-9-octadecenamide Journal of the American Chemical Society 1996 118:5938-5945 DOI:10.1021/ja954064z
- Boger, D. L.*, Zhou, J. C.* Alternative synthesis of the cycloisodityrosine subunit of deoxybouvardin, RA-VII, and related agents: reassignment of the stereochemistry of prior intermediates Journal of Organic Chemistry 1996 61:3938-3939 DOI:10.1021/jo9604144 PMID:11667262 (* = equal contribution)
- Boger, D. L.*, Zhou, J. C.*, Cai, H. Demonstration and definition of the noncovalent binding selectivity of agents related to CC-1065 by an affinity cleavage agent: Noncovalent binding coincidental with alkylation Bioorganic & Medicinal Chemistry 1996 4:859-867 DOI:10.1016/0968-0896(96)00073-9 PMID:8818235 (* = equal contribution)
- Boger, D. L.*, Zhou, J. C.*, Borzilleri, R. M., Nukui, S. Synthesis of (9S,12S)-cycloisodityrosine and its unnatural (9R,12S)-diastereomer Bioorganic & Medicinal Chemistry Letters 1996 6:1089-1092 DOI:10.1016/0960-894x(96)00179-5 (* = equal contribution)
- Boger, D. L., Borzilleri, R. M., Nukui, S. Synthesis of (r)-(4-methoxy-3,5-dihydroxyphenyl)glycine derivatives: The central amino acid of vancomycin and related agents Journal of Organic Chemistry 1996 61:3561-3565 DOI:10.1021/jo960085f
- Cheng, S., Tarby, C. M., Comer, D. D., Williams, J. P., Caporale, L. H., Myers, P. L., Boger, D. L. A solution-phase strategy for the synthesis of chemical libraries containing small organic molecules: a universal and dipeptide mimetic template Bioorganic & Medicinal Chemistry 1996 4:727-737 DOI:10.1016/0968-0896(96)00069-7 PMID:8804539
- Cheng, S., Comer, D. D., Williams, J. P., Myers, P. L., Boger, D. L. Novel solution phase strategy for the synthesis of chemical libraries containing small organic molecules Journal of the American Chemical Society 1996 118:2567-2573 DOI:10.1021/ja9530681
- Boger, D. L., McKie, J. A., Han, N. H., Tarby, C. M., Riggs, H. Q. W., Kitos, P. A. A Hammett correlation for CC-1065 and duocarmycin analogs: magnitude of substituent electronic effects on functional reactivity Bioorganic & Medicinal Chemistry Letters 1996 6:659-664 DOI:10.1016/0960-894x(96)00093-5
- Boger, D. L., McKie, J. A., Cai, H., Cacciari, B., Baraldi, P. G. Synthesis and properties of substituted CBI analogs of CC-1065 and the duocarmycins incorporating the 7-methoxy-1,2,9,9a-tetrahydrocyclopropa c benz e indol-4-one (MCBI) alkylation subunit: magnitude of electronic effects on the functional reactivity Journal of Organic Chemistry 1996 61:1710-1729 DOI:10.1021/jo952033g PMID:11667041
- Boger, D. L., McKie, J. A., Nishi, T., Ogiku, T. Enantioselective total synthesis of (+)-duocarmycin A, epi-(+)-duocarmycin a, and their unnatural enantiomers Journal of the American Chemical Society 1996 118:2301-2302 DOI:10.1021/ja953777e
- Boger, D. L.*, Tarby, C. M.*, Myers, P. L., Caporale, L. H. Generalized dipeptidomimetic template: solution phase parallel synthesis of combinatorial libraries Journal of the American Chemical Society 1996 118:2109-2110 DOI:10.1021/ja9539711 (* = equal contribution)
- Boger, D. L., Chen, J. H., Saionz, K. W. (-)-Sandramycin: total synthesis and characterization of DNA binding properties Journal of the American Chemical Society 1996 118:1629-1644 DOI:10.1021/ja952799y
- Boger, D. L., Teramoto, S., Cai, H. Synthesis and evaluation of deglycobleomycin A(2) analogues containing a tertiary N-methyl amide and simple ester replacement for the L-histidine secondary amide: Direct functional characterization of the requirement for secondary amide metal complexation Bioorganic & Medicinal Chemistry 1996 4:179-193 DOI:10.1016/0968-0896(95)00183-2 PMID:8814877
- Boger, D. L., Ramsey, T. M., Cai, H. Synthesis and evaluation of potential N-pi and N-sigma metal chelation sites within the beta-hydroxy-L-histidine subunit of bleomycin A(2): Functional characterization of imidazole N-pi metal complexation Bioorganic & Medicinal Chemistry 1996 4:195-207 DOI:10.1016/0968-0896(95)00184-0 PMID:8814878
- Cravatt, B. F., Lerner, R. A., Boger, D. L. Structure determination of an endogenous sleep-inducing lipid, cis-9-octadecenamide (oleamide): A synthetic approach to the chemical analysis of trace quantities of a natural product Journal of the American Chemical Society 1996 118:580-590 DOI:10.1021/ja9532345
- Boger, D. L. Editorial Bioorganic & Medicinal Chemistry Letters 1996 6:R3-R3 DOI:10.1016/s0960-894x(96)90241-3
- Johnson, D. S., Boger, D. L. Control of chemoselectivity in catalytic rhodium carbenoid reactions through ligand modification. Comments Chemtracts: Inorganic Chemistry 1996 8:116-122
- Boger, D. L. Cycloaddition reactions of azadienes, cyclopropenone ketals, and related systems: scope and applications Chemtracts: Organic Chemistry 1996 9:149-189
- Boger, D. L., Borzilleri, R. M., Nukui, S. Synthesis of appropriately functionalized vancomycin CD and DE ring systems Bioorganic & Medicinal Chemistry Letters 1995 5:3091-3096 DOI:10.1016/0960-894x(95)00543-9
- Boger, D. L., Takahashi, K. Total synthesis of granditropone, grandirubrine, imerubrine, and isoimerubrine Journal of the American Chemical Society 1995 117:12452-12459 DOI:10.1021/ja00155a009
- Boger, D. L., Huter, O., Mbiya, K., Zhang, M. S. Total synthesis of natural and ent-fredericamycin-a Journal of the American Chemical Society 1995 117:11839-11849 DOI:10.1021/ja00153a004
- Boger, D. L.*, Zhou, J. C.*, Winter, B., Kitos, P. A. Key analogs of the tetrapeptide subunit of RA-VII and deoxybouvardin Bioorganic & Medicinal Chemistry 1995 3:1579-1593 DOI:10.1016/0968-0896(95)00141-7 PMID:8770383 (* = equal contribution)
- Boger, D. L., Mesini, P. DNA alkylation properties of CC-1065 and duocarmycin analogs incorporating the 2,3,10,10a-tetrahydrocyclopropa d benzo f quinol-5-one alkylation subunit - identification of subtle structural features that contribute to the regioselectivity of the adenine N3 alkylation reaction Journal of the American Chemical Society 1995 117:11647-11655 DOI:10.1021/ja00152a004
- Boger, D. L., Chen, J. H. A modified friedlander condensation for the synthesis of 3-hydroxyquinoline-2-carboxylates Journal of Organic Chemistry 1995 60:7369-7371 DOI:10.1021/jo00127a055
- Boger, D. L., Yun, W. Y., Han, N. H. 1,2,9,9a-tetrahydrocyclopropa[c]benz[e]indol-4-one (CBI) analogs of CC-1065 and the duocarmycins: synthesis and evaluation Bioorganic & Medicinal Chemistry 1995 3:1429-1453 DOI:10.1016/0968-0896(95)00130-9 PMID:8634824
- Boger, D. L., Colletti, S. L., Teramoto, S., Ramsey, T. M., Zhou, J. C. Synthesis of key analogs of bleomycin A(2) that permit a systematic evaluation of the linker region - identification of an exceptionally prominent role for the L-threonine substituent Bioorganic & Medicinal Chemistry 1995 3:1281-1295 DOI:10.1016/0968-0896(95)00113-u PMID:8564421
- Boger, D. L., Teramoto, S., Zhou, J. C. Key synthetic analogs of bleomycin A(2) that directly address the effect and role of the disaccharide - demannosylbleomycin A(2) and alpha-D-mannopyranosyldeglycobleomycin A(2) Journal of the American Chemical Society 1995 117:7344-7356 DOI:10.1021/ja00133a008
- Boger, D. L.*, Zhou, J. C.* N-desmethyl derivatives of deoxybouvardin and RA-VII: synthesis and evaluation Journal of the American Chemical Society 1995 117:7364-7378 DOI:10.1021/ja00133a010 (* = equal contribution)
- Boger, D. L., Patane, M. A., Zhou, J. C. Solution-phase conformational studies of the cyclic peptide RA-VII: lithium-chloride perturbation of the conformational equilibria Journal of the American Chemical Society 1995 117:7357-7363 DOI:10.1021/ja00133a009
- Boger, D. L., Teramoto, S., Honda, T., Zhou, J. C. Synthesis and evaluation of the fully functionalized bleomycin A(2) metal-binding domain-containing the 2-O-(3-O-carbamoyl-alpha-D-mannopyranosyl)-alpha-L-gulopyranosyl disaccharide Journal of the American Chemical Society 1995 117:7338-7343 DOI:10.1021/ja00133a007
- Cravatt, B. F., Prosperogarcia, O., Siuzdak, G., Gilula, N. B., Henriksen, S. J., Boger, D. L., Lerner, R. A. Chemical characterization of a family of brain lipids that induce sleep Science 1995 268:1506-1509 DOI:10.1126/science.7770779 PMID:7770779
- Boger, D. L., Borzilleri, R. M. An unusually facile SNAr 14-membered biaryl ether macrocyclization reaction suitable for preparation of the cycloisodityrosine subunit of bouvardin, deoxybouvardin and related agents Bioorganic & Medicinal Chemistry Letters 1995 5:1187-1190 DOI:10.1016/0960-894x(95)00192-v
- Boger, D. L., Yun, W. Y., Cai, H., Han, N. H. CBI-CDPBO1 and CBI-CDPBI1 - CC-1065 analogs containing deep-seated modifications in the DNA-binding subunit Bioorganic & Medicinal Chemistry 1995 3:761-775 DOI:10.1016/0968-0896(95)00066-p PMID:7582954
- Boger, D. L., Yun, W. Y., Han, N. H., Johnson, D. S. CC-1065 CBI analogs - an example of enhancement of DNA alkylation efficiency through introduction of stabilizing electrostatic interactions Bioorganic & Medicinal Chemistry 1995 3:611-621 DOI:10.1016/0968-0896(95)00048-l PMID:7582940
- Boger, D. L.*, Johnson, D. S.* CC-1065 and the duocarmycins - unraveling the keys to a new class of naturally derived DNA alkylating-agents Proceedings of the National Academy of Sciences of the United States of America 1995 92:3642-3649 DOI:10.1073/pnas.92.9.3642 PMID:7731958 (* = equal contribution)
- Boger, D. L., McKie, J. A. An efficient synthesis of 1,2,9,9a-tetrahydrocyclopropa c benz e indol-4-one (CBI) - an enhanced and simplified analog of the CC-1065 and duocarmycin alkylation subunits Journal of Organic Chemistry 1995 60:1271-1275 DOI:10.1021/jo00110a034
- Boger, D. L.*, Johnson, D. S.* Second definitive test of proposed models for the origin of the CC-1065 and duocarmycin DNA alkylation selectivity Journal of the American Chemical Society 1995 117:1443-1444 DOI:10.1021/ja00109a035 (* = equal contribution)
- Boger, D. L., Nishi, T. Diastereoselective dieckmann condensation suitable for introduction of the duocarmycin A C6 center - development of a divergent strategy for the total synthesis of duocarmycins A and SA Bioorganic & Medicinal Chemistry 1995 3:67-77 DOI:10.1016/0968-0896(94)00147-u PMID:8612048
- Boger, D. L. The duocarmycins: synthetic and mechanistic studies Accounts of Chemical Research 1995 28:20-29 DOI:10.1021/ar00049a004
- Boger, D. L. Total synthesis of (+)- and ent-(-)-duocarmycin SA Advances in Nitrogen Heterocycles 1995 1:229-247
- Boger, D. L., Mesini, P. Design, synthesis, and evaluation of CC-1065 and duocarmycin analogs incorporating the 2,3,10,10a-tetrahydro-1H-cyclopropa d benzo f quinol-5-one (CBQ) alkylation subunit - identification and structural origin of subtle stereoelectronic features that govern reactivity and regioselectivity Journal of the American Chemical Society 1994 116:11335-11348 DOI:10.1021/ja00104a013
- Lerner, R. A., Siuzdak, G., Prosperogarcia, O., Henriksen, S. J., Boger, D. L., Cravatt, B. F. Cerebrodiene: A brain lipid isolated from sleep-deprived cats Proceedings of the National Academy of Sciences of the United States of America 1994 91:9505-9508 DOI:10.1073/pnas.91.20.9505 PMID:7937797 PMCID:PMC44841
- Boger, D. L., Patane, M. A., Zhou, J. C. Total synthesis of bouvardin, O-methylbouvardin, and O-methyl-N-9-desmethylbouvardin Journal of the American Chemical Society 1994 116:8544-8556 DOI:10.1021/ja00098a015
- Boger, D. L., Yun, W. Y. CBI-TMI - synthesis and evaluation of a key analog of the duocarmycins - validation of a direct relationship between chemical solvolytic stability and cytotoxic potency and confirmation of the structural features responsible for the distinguishing behavior of enantiomeric pairs of agents Journal of the American Chemical Society 1994 116:7996-8006 DOI:10.1021/ja00097a006
- Boger, D. L., Kochanny, M. J. Inverse electron demand Diels-Alder reactions of heterocyclic azadienes - 4+2 -cycloaddition reaction of amidines with 1,3,5-triazines Journal of Organic Chemistry 1994 59:4950-4955 DOI:10.1021/jo00096a044
- Boger, D. L., Nishi, T., Teegarden, B. R. P-quinonemethide analog of the CC-1065 and duocarmycin alkylation subunits Journal of Organic Chemistry 1994 59:4943-4949 DOI:10.1021/jo00096a043
- Boger, D. L., Lerner, R. A., Cravatt, B. F. Synthesis of a functionalized rigid bicyclo[2.2.1]heptane: a useful hapten for eliciting catalytic antibodies Journal of Organic Chemistry 1994 59:5078-5079 DOI:10.1021/jo00096a064
- Boger, D. L., Mesini, P., Tarby, C. M. Chemical and structural comparison of N-BOC-CBQ and N-BOC-CBI - identification and structural origin of an unappreciated but productive stability of the CC-1065 and duocarmycin SA alkylation subunits Journal of the American Chemical Society 1994 116:6461-6462 DOI:10.1021/ja00093a067
- Cravatt, B. F., Ashley, J. A., Janda, K. D., Boger, D. L., Lerner, R. A. Crossing extreme mechanistic barriers by antibody catalysis: Syn elimination to a cis olefin Journal of the American Chemical Society 1994 116:6013-6014 DOI:10.1021/ja00092a080
- Boger, D. L., Honda, T. Total synthesis of bleomycin A(2) and related agents .4. Synthesis of the disaccharide subunit - 2-O-(3-O-carbamoyl-alpha-D-mannopyranosyl)-L-gulopyranose and completion of the total synthesis of bleomycin a(2) Journal of the American Chemical Society 1994 116:5647-5656 DOI:10.1021/ja00092a014
- Boger, D. L., Colletti, S. L., Honda, T., Menezes, R. F. Total synthesis of bleomycin-A(2) and related agents .1. Synthesis and DNA-binding properties of the extended C-terminus - tripeptide-S, tetrapeptide-S, pentapeptide-S, and related agents Journal of the American Chemical Society 1994 116:5607-5618 DOI:10.1021/ja00092a011
- Boger, D. L., Honda, T., Dang, Q. Total synthesis of bleomycin-A(2) and related agents .2. Synthesis of (-)-pyrimidoblamic acid, epi-(+)-pyrimidoblamic acid, (+)-desacetamidopyrimidoblamic acid, and (-)-descarboxamidopyrimidoblamic acid Journal of the American Chemical Society 1994 116:5619-5630 DOI:10.1021/ja00092a012
- Boger, D. L., Honda, T., Menezes, R. F., Colletti, S. L. Total synthesis of bleomycin-A(2) and related agents .3. Synthesis and comparative-evaluation of deglycobleomycin-A(2), epideglycobleomycin-A(2), deglycobleomycin-A(1), and desacetamidodeglycobleomycin, descarboxamidodeglycobleomycin, desmethyldeglycobleomycin, and desimidazolyldeglycobleomycin-A(2) Journal of the American Chemical Society 1994 116:5631-5646 DOI:10.1021/ja00092a013
- Boger, D. L.*, Zhu, Y.* Diels-Alder reactions of cyclopropenone ketals - a concise tropolone annulation applicable to rubrolone-C ring introduction Journal of Organic Chemistry 1994 59:3453-3458 DOI:10.1021/jo00091a040 (* = equal contribution)
- Boger, D. L., Yun, W. Y. Role of the CC-1065 and duocarmycin N-2 substituent - validation of a direct relationship between solvolysis chemical-stability and in-vitro biological potency Journal of the American Chemical Society 1994 116:5523-5524 DOI:10.1021/ja00091a088
- Boger, D. L. Design, synthesis, and evaluation of DNA minor-groove binding-agents - the duocarmycins Pure and Applied Chemistry 1994 66:837-844 DOI:10.1351/pac199466040837
- Wrasidlo, W., Johnson, D. S., Boger, D. L. Induction of endonucleolytic DNA fragmentation and apoptosis by the duocarmycins Bioorganic & Medicinal Chemistry Letters 1994 4:631-636 DOI:10.1016/s0960-894x(01)80168-2
- Mohamadi, F., Spees, M. M., Staten, G. S., Marder, P., Kipka, J. K., Johnson, D. A., Boger, D. L., Zarrinmayeh, H. Total synthesis and biological properties of novel antineoplastic (chloromethyl)furanoindolines - an asymmetric hydroboration mediated synthesis of the alkylation subunits Journal of Medicinal Chemistry 1994 37:232-239 DOI:10.1021/jm00028a005 PMID:8295210
- Boger, D. L., Honda, T., Menezes, R. F., Colletti, S. L., Dang, Q., Yang, W. J. Total syntheses of (+)-p-3a, epi-(-)-p-3a, and (-)-desacetamido p-3a Journal of the American Chemical Society 1994 116:82-92 DOI:10.1021/ja00080a010
- Boger, D. L.*, Johnson, D. S.*, Yun, W. Y. (+)- and ent-(-)-duocarmycin SA and (+)- and ent-(-)-N-BOC-DSA DNA alkylation properties - alkylation site models that accommodate the offset AT-rich adenine N3 alkylation selectivity of the enantiomeric agents Journal of the American Chemical Society 1994 116:1635-1656 DOI:10.1021/ja00084a004 (* = equal contribution)
- Johnson, D. S., Boger, D. L. Control of chemoselectivity in catalytic rhodium carbenoid reactions through ligand modification Chemtracts: Organic Chemistry 1994 7:31-37
- Boger, D. L., Patane, M. A., Jin, Q., Kitos, P. A. Design, synthesis and evaluation of bouvardin, deoxybouvardin and RA-I-XIV pharmacophore analogs Bioorganic & Medicinal Chemistry 1994 2:85-100 DOI:10.1016/s0968-0896(00)82005-2 PMID:7922127
- Boger, D. L.*, Johnson, D. S.*, Yun, W., Tarby, C. M. Molecular basis for sequence selective DNA alkylation by (+)- and ent-(-)-CC-1065 and related agents: alkylation site models that accommodate the offset AT-rich adenine N3 alkylation selectivity Bioorganic & Medicinal Chemistry 1994 2:115-135 DOI:10.1016/S0968-0896(00)82007-6 PMID:7922122 (* = equal contribution)
- Boger, D. L., Chen, J. H. (-)-sandramycin - total synthesis and preliminary DNA-binding properties Journal of the American Chemical Society 1993 115:11624-11625 DOI:10.1021/ja00077a082
- Boger, D. L., Baldino, C. M. D, l- and meso-isochrysohermidin - total synthesis and interstrand DNA cross-linking Journal of the American Chemical Society 1993 115:11418-11425 DOI:10.1021/ja00077a046
- Boger, D. L.*, Zhou, J. C.* Total synthesis of (+)-piperazinomycin Journal of the American Chemical Society 1993 115:11426-11433 DOI:10.1021/ja00077a047 (* = equal contribution)
- Boger, D. L., Cassidy, K. C., Nakahara, S. Total synthesis of streptonigrone Journal of the American Chemical Society 1993 115:10733-10741 DOI:10.1021/ja00076a035
- Boger, D. L., Yun, W. Y. Reversibility of the duocarmycin-A and SA DNA alkylation reaction Journal of the American Chemical Society 1993 115:9872-9873 DOI:10.1021/ja00074a093
- Boger, D. L., Machiya, K., Hertzog, D. L., Kitos, P. A., Holmes, D. Total synthesis and preliminary evaluation of (+)-duocarmycin and ent-(-)-duocarmycin SA Journal of the American Chemical Society 1993 115:9025-9036 DOI:10.1021/ja00073a019
- Wasserman, H. H., Desimone, R. W., Boger, D. L., Baldino, C. M. Singlet oxygen oxidation of bipyrroles - total synthesis of d,l-isochrysohermidin and meso-isochrysohermidin Journal of the American Chemical Society 1993 115:8457-8458 DOI:10.1021/ja00071a069
- Boger, D. L. Design, synthesis, and evaluation of DNA minor-groove binding-agents Pure and Applied Chemistry 1993 65:1123-1132 DOI:10.1351/pac199365061123
- Boger, D. L.*, Zhou, J. C.* CDPI3-enediyne and CDPI3-EDTA conjugates - a new class of DNA cleaving agents Journal of Organic Chemistry 1993 58:3018-3024 DOI:10.1021/jo00063a019 (* = equal contribution)
- Boger, D. L., Yohannes, D., Zhou, J. C., Patane, M. A. Total synthesis of cycloisodityrosine, RA-VII, deoxybouvardin, and N29-desmethyl-RA-VII - identification of the pharmacophore and reversal of the subunit functional roles Journal of the American Chemical Society 1993 115:3420-3430 DOI:10.1021/ja00062a004
- Boger, D. L., Nomoto, Y., Teegarden, B. R. Vancomycin and ristocetin models - synthesis via the Ullmann macrocyclization reaction Journal of Organic Chemistry 1993 58:1425-1433 DOI:10.1021/jo00058a024
- Boger, D. L., Honda, T. Studies on the synthesis of bleomycin-A(2) - observations on a diastereoselective imine addition-reaction for C2-acetamido side-chain introduction Tetrahedron Letters 1993 34:1567-1570 DOI:10.1016/0040-4039(93)85008-k
- Boger, D. L., Yohannes, D. K-13 and OF4949 - evaluation of key partial structures and pharmacophore delineation Bioorganic & Medicinal Chemistry Letters 1993 3:245-250 DOI:10.1016/s0960-894x(01)80885-4
- Boger, D. L., Corbett, W. L. 4pi participation of 1-aza-1,3-butadienes in [4 + 2] cycloaddition reactions: intramolecular Diels-Alder reactions of alpha,beta-unsaturated N-sulfonylimines Journal of Organic Chemistry 1993 58:2068-2074 DOI:10.1021/jo00060a022
- Boger, D. L.*, Johnson, D. S.*, Palanki, M. S., Kitos, P. A., Chang, J., Dowell, P. Evaluation of functional analogs of CC-1065 and the duocarmycins incorporating the cross-linking 9a-chloromethyl-1,2,9,9a-tetrahydrocyclopropa[c]benz[e]indol-4-on e (C2BI) alkylation subunit Bioorganic & Medicinal Chemistry 1993 1:27-38 DOI:10.1016/S0968-0896(00)82100-8 PMID:8081835 (* = equal contribution)
- Boger, D. L., Menezes, R. F., Honda, T. Total synthesis of (-)-pyrimidoblamic acid and deglycobleomycin A2 Angewandte Chemie-International Edition 1993 32:273-275 DOI:10.1002/anie.199302731
- Boger, D. L., Machiya, K. Total synthesis of (+)-duocarmycin SA Journal of the American Chemical Society 1992 114:10056-10058 DOI:10.1021/ja00051a045
- Boger, D. L., Yang, W. J. P-3A and (-)-desacetamido P-3A - demonstration and study of their effective functional cleavage of duplex DNA Bioorganic & Medicinal Chemistry Letters 1992 2:1649-1654 DOI:10.1016/s0960-894x(00)80449-7
- Boger, D. L., Palanki, M. S. S. Functional analogs of CC-1065 and the duocarmycins incorporating the 9A-(chloromethyl)-1,2,9,9a-tetrahydrocyclopropa c benz e indol-4-one (C2BI) alkylation subunit - synthesis and preliminary DNA alkylation studies Journal of the American Chemical Society 1992 114:9318-9327 DOI:10.1021/ja00050a012
- Boger, D. L., Menezes, R. F., Yang, W. J. A simple method for the purification and isolation of bleomycin-A2 Bioorganic & Medicinal Chemistry Letters 1992 2:959-962 DOI:10.1016/s0960-894x(00)80597-1
- Boger, D. L., Corbett, W. L. A convenient and general preparation of n-sulfonylimines Journal of Organic Chemistry 1992 57:4777-4780 DOI:10.1021/jo00043a047
- Boger, D. L., Zhang, M. S. A concise synthesis of the fredericamycin-a DEF ring-system - 4+2 cycloaddition reactions of 1-aza-1,3-butadienes Journal of Organic Chemistry 1992 57:3974-3977 DOI:10.1021/jo00040a044
- Boger, D. L., Munk, S. A. DNA alkylation properties of enhanced functional analogs of cc-1065 incorporating the 1,2,9,9a-tetrahydrocyclopropa 1,2-c benz 1,2-e indol-4-one (cbi) alkylation subunit Journal of the American Chemical Society 1992 114:5487-5496 DOI:10.1021/ja00040a001
- Boger, D. L., Yun, W. Y., Teegarden, B. R. An improved synthesis of 1,2,9,9a-tetrahydrocyclopropa c benz e indol-4-one (CBI) - a simplified analog of the CC-1065 alkylation subunit Journal of Organic Chemistry 1992 57:2873-2876 DOI:10.1021/jo00036a023
- Boger, D. L., Curran, T. T. Synthesis of the lower subunit of rhizoxin Journal of Organic Chemistry 1992 57:2235-2244 DOI:10.1021/jo00034a010
- Boger, D. L., Dang, Q. Synthesis of desacetamido P-3A: 1,3,5-triazine .fwdarw. pyrimidine heteroaromatic azadiene Diels-Alder reaction Journal of Organic Chemistry 1992 57:1631-1633 DOI:10.1021/jo00032a001
- Boger, D. L., Mathvink, R. J. Acyl radicals - intermolecular and intramolecular alkene addition-reactions Journal of Organic Chemistry 1992 57:1429-1443 DOI:10.1021/jo00031a021
- Boger, D. L., Yohannes, D., Myers, J. B. Synthesis of N29-desmethyl RA-VII. Identification of the pharmacophore of RA-I-VII and deoxybouvardin and reassignment of the subunit functional roles Journal of Organic Chemistry 1992 57:1319-1321 DOI:10.1021/jo00031a001
- Boger, D. L., Sakya, S. M. CC-1065 partial structures - enhancement of noncovalent affinity for DNA minor groove binding through introduction of stabilizing electrostatic interactions Journal of Organic Chemistry 1992 57:1277-1284 DOI:10.1021/jo00030a042
- Boger, D. L., Yun, W. Y., Terashima, S., Fukuda, Y., Nakatani, K., Kitos, P. A., Jin, Q. DNA alkylation properties of enhanced functional analogs of CC-1065 incorporating the 1,2,9,9a-tetrahydrocyclopropa[1,2-c]benz[1,2-e]indol-4-one (CBI) alkylation subunit Bioorganic & Medicinal Chemistry Letters 1992 2:759-765 DOI:10.1016/s0960-894x(00)80407-2
- Boger, D. L., Menezes, R. F., Dang, Q., Yang, W. J. Deglyco GABA,gly-desacetamidobleomycin-A2 - a simplified synthetic model for bleomycin-A2 Bioorganic & Medicinal Chemistry Letters 1992 2:261-266 DOI:10.1016/s0960-894x(01)81076-3
- Boger, D. L. Design, synthesis, and evaluation of functional analogs of CC-1065 and the duocarmycins: a study of structural features effecting DNA binding selectivity Advances in Heterocyclic Natural Product Synthesis 1992 2:1-188
- Boger, D. L., Panek, J. S., Patel, M. Preparation and Diels-Alder reaction of a reactive, electron-deficient heterocyclic azadiene: dimethyl 1,2,4,5-tetrazine-3,6-dicarboxylate. 1,2-Diazine and pyrrole introduction Organic Syntheses 1992 70:79-92
- Boger, D. L., Menezes, R. F., Dang, Q. Synthesis of desacetamidopyrimidoblamic acid and deglyco desacetamidobleomycin A2 Journal of Organic Chemistry 1992 57:4333-4336 DOI:10.1021/jo00042a004
- Boger, D. L., Menezes, R. F. Synthesis of tri- and tetrapeptide S: the extended C-terminus of bleomycin A2 Journal of Organic Chemistry 1992 57:4331-4333 DOI:10.1021/jo00042a003
- Boger, D. L.*, Zhu, Y.* Studies on the synthesis of rubrolone: 4π participation of O-alkyl α,β-unsaturated oximes in intramolecular [4 + 2] cycloaddition reactions Tetrahedron Letters 1991 32:7643-7646 DOI:10.1016/0040-4039(91)80554-j (* = equal contribution)
- Boger, D. L., Baldino, C. M. Singlet oxygen mediated oxidative decarboxylation of pyrrole-2-carboxylic acids Journal of Organic Chemistry 1991 56:6942-6944 DOI:10.1021/jo00024a045
- Boger, D. L., Myers, J. B. Design and synthesis of a conformational analog of deoxybouvardin Journal of Organic Chemistry 1991 56:5385-5390 DOI:10.1021/jo00018a035
- Boger, D. L., Ishizaki, T., Zarrinmayeh, H. Isolation and characterization of the duocarmycin adenine DNA adduct Journal of the American Chemical Society 1991 113:6645-6649 DOI:10.1021/ja00017a042
- Boger, D. L., Sakya, S. M., Yohannes, D. Total synthesis of combretastatin D-2 - intramolecular ullmann macrocyclization reaction Journal of Organic Chemistry 1991 56:4204-4207 DOI:10.1021/jo00013a024
- Boger, D. L., Zhang, M. S. Total synthesis of (+/-)-cis-trikentrin-A and (+/-)-trans-trikentrin-A - Diels-Alder reactions of heteroaromatic azadienes Journal of the American Chemical Society 1991 113:4230-4234 DOI:10.1021/ja00011a026
- Boger, D. L., Munk, S. A., Zarrinmayeh, H. (+)-CC-1065 DNA alkylation - key studies demonstrating a noncovalent binding selectivity contribution to the alkylation selectivity Journal of the American Chemical Society 1991 113:3980-3983 DOI:10.1021/ja00010a046
- Boger, D. L., Munk, S. A., Zarrinmayeh, H., Ishizaki, T., Haught, J., Bina, M. An alternative and convenient strategy for generation of substantial quantities of singly 5-32P-end-labeled double-stranded DNA for binding-studies - development of a protocol for examination of functional features of (+)-CC-1065 and the duocarmycins that contribute to their sequence-selective DNA alkylation properties Tetrahedron 1991 47:2661-2682 DOI:10.1016/s0040-4020(01)81798-1
- Boger, D. L. Recent advances in bioorganic chemistry. Preface Tetrahedron 1991 47:xv DOI:10.1016/s0040-4020(01)81771-3
- Boger, D. L., Munk, S. A., Ishizaki, T. (+)-CC-1065 DNA alkylation - observation of an unexpected relationship between cyclopropane electrophile reactivity and the intensity of DNA alkylation Journal of the American Chemical Society 1991 113:2779-2780 DOI:10.1021/ja00007a077
- Boger, D. L., Jacobson, I. C. Synthesis and preliminary evaluation of the fredericamycin-A ABCDE ring-system Journal of Organic Chemistry 1991 56:2115-2122 DOI:10.1021/jo00006a029
- Boger, D. L., Yohannes, D. Intramolecular Ullmann condensation reaction - an effective approach to macrocyclic diaryl ethers Journal of Organic Chemistry 1991 56:1763-1767 DOI:10.1021/jo00005a020
- Boger, D. L., Corbett, W. L., Curran, T. T., Kasper, A. M. Inverse electron demand Diels-Alder reactions of N-sulfonyl alpha,beta-unsaturated imines - a general-approach to implementation of the 4-pi participation of 1-aza-1,3-butadienes in Diels-Alder reactions Journal of the American Chemical Society 1991 113:1713-1729 DOI:10.1021/ja00005a040
- Boger, D. L., Yohannes, D. Total synthesis of deoxybouvardin and RA-VII - macrocyclization via an intramolecular Ullmann reaction Journal of the American Chemical Society 1991 113:1427-1429 DOI:10.1021/ja00004a062
- Boger, D. L., Zarrinmayeh, H., Munk, S. A., Kitos, P. A., Suntornwat, O. Demonstration of a pronounced effect of noncovalent binding selectivity on the (+)-CC-1065 DNA alkylation and identification of the pharmacophore of the alkylation subunit Proceedings of the National Academy of Sciences of the United States of America 1991 88:1431-1435 DOI:10.1073/pnas.88.4.1431 PMID:1847523
- Boger, D. L., Nakahara, S. Diels-Alder reactions of N-sulfonyl-1-aza-1,3-butadienes: Development of a synthetic approach to the streptonigrone C ring Journal of Organic Chemistry 1991 56:880-884 DOI:10.1021/jo00002a077
- Boger, D. L., Ishizaki, T., Zarrinmayeh, H., Kitos, P. A., Suntornwat, O. A potent, simple derivative of an analog of the CC-1065 alkylation subunit Bioorganic & Medicinal Chemistry Letters 1991 1:55-58 DOI:10.1016/s0960-894x(01)81090-8
- Boger, D. L. Duocarmycins: a new class of sequence selective DNA minor groove alkylating agents Chemtracts: Organic Chemistry 1991 4:329-349
- Boger, D. L., Myers, J. B., Yohannes, D., Kitos, P. A., Suntornwat, O., Kitos, J. C. Evaluation of bouvardin, deoxybouvardin, and RA-I - RA-VII partial structures - reassignment of the pharmacophore Bioorganic & Medicinal Chemistry Letters 1991 1:313-316 DOI:10.1016/s0960-894x(01)80815-5
- Boger, D. L., Zhang, M. Solution structure of FKBP, a rotamase enzyme and receptor for FK506 and rapamycin. Atomic structure of FKBP-FK506, an immunophilin-immunosuppressant complex Chemtracts: Organic Chemistry 1991 4:272-278
- Boger, D. L., Ishizaki, T., Sakya, S. M., Munk, S. A., Kitos, P. A., Jin, Q., Besterman, J. M. Synthesis and preliminary evaluation of (+)-CBI-indole2 - an enhanced functional analog of (+)-CC-1065 Bioorganic & Medicinal Chemistry Letters 1991 1:115-120 DOI:10.1016/s0960-894x(00)80243-7
- Cable, M. P., Coleman, R. S., Danishefsky, S. J., Boger, D. L., Sakya, S. M. Total synthesis of calicheamicinone: a solution to the problem of the elusive urethane Chemtracts: Organic Chemistry 1991 4:129-134
- Boger, D. L., Yohannes, D. Total synthesis of L,L-isodityrosine and isodityrosine-derived agents - K-13, OF4949-III, and OF4949-IV Journal of Organic Chemistry 1990 55:6000-6017 DOI:10.1021/jo00311a019
- Boger, D. L., Ishizaki, T., Zarrinmayeh, H., Munk, S. A., Kitos, P. A., Suntornwat, O. Duocarmycin pyrindamycin DNA alkylation properties and identification, synthesis, and evaluation of agents incorporating the pharmacophore of the duocarmycin pyrindamycin alkylation subunit - identification of the CC-1065-duocarmycin common pharmacophore Journal of the American Chemical Society 1990 112:8961-8971 DOI:10.1021/ja00180a048
- Boger, D. L., Ishizaki, T., Kitos, P. A., Suntornwat, O. Synthesis of N-(tert-butyloxycarbonyl)-CBI, CBI, CBI-CBI1, and CBI-CDPI2 - enhanced functional analogs of CC-1065 incorporating the 1,2,9,9a-tetrahydrocyclopropa c benz e indol-4-one (CBI) left-hand subunit Journal of Organic Chemistry 1990 55:5823-5832 DOI:10.1021/jo00310a013
- Boger, D. L., Curran, T. T. Diels-Alder reactions of 1-aza-1,3-butadienes: room temperature, endo-selective LUMOdiene-controlled [4 + 2] cycloaddition reactions of N-sulfonyl-4-(ethoxycarbonyl)-1-aza-1,3-butadienes Journal of Organic Chemistry 1990 55:5439-5442 DOI:10.1021/jo00307a009
- Boger, D. L., Mathvink, R. J. Tandem free-radical ring expansion and 5-exo-dig 5-hexynyl radical cyclization: a useful approach to fused bicyclic carbocycles Journal of Organic Chemistry 1990 55:5442-5444 DOI:10.1021/jo00307a010
- Boger, D. L. Diels-Alder reactions of azadienes: scope and applications Bulletin des Societes Chimiques Belges 1990 99:599-615 DOI:10.1002/bscb.19900990902
- Boger, D. L., Ishizaki, T., Zarrinmayeh, H., Kitos, P. A., Suntornwat, O. Synthesis and preliminary evaluation of agents incorporating the pharmacophore of the duocarmycin pyrindamycin alkylation subunit - identification of the cc-1065 duocarmycin common pharmacophore Journal of Organic Chemistry 1990 55:4499-4502 DOI:10.1021/jo00302a002
- Boger, D. L., Ishizaki, T., Zarrinmayeh, H., Kitos, P. A., Suntornwat, O. Synthesis and preliminary evaluation of agents incorporating the pharmacophore of the duocarmycin/pyrindamycin alkylation subunit: identification of the CC-1065/duocarmycin common pharmacophore Journal of Organic Chemistry 1990 55:4499-4502 DOI:10.1021/jo00302a002
- Boger, D. L., Wysocki, R. J., Ishizaki, T. Synthesis of n-(phenylsulfonyl)-CI, N-((tert-butyloxy)carbonyl)-CI, CI-CDPI1, and CI-CDPI2 - CC-1065 functional analogs incorporating the parent 1,2,7,7a-tetrahydrocycloprop 1,2-c indol-4-one (CI) left-hand subunit Journal of the American Chemical Society 1990 112:5230-5240 DOI:10.1021/ja00169a034
- Boger, D. L., Corbett, W. L., Wiggins, J. M. Room-temperature, endo-specific 1-aza-1,3-butadiene Diels-Alder reactions: acceleration of the LUMOdiene-controlled [4 + 2] cycloaddition reactions through noncomplementary aza diene substitution Journal of Organic Chemistry 1990 55:2999-3000 DOI:10.1021/jo00297a006
- Boger, D. L., Mathvink, R. J. Intramolecular acyl radical alkene addition-reactions - macrocyclization reactions Journal of the American Chemical Society 1990 112:4008-4011 DOI:10.1021/ja00166a044
- Boger, D. L., Mathvink, R. J. Tandem free-radical alkene addition-reactions of acyl radicals Journal of the American Chemical Society 1990 112:4003-4008 DOI:10.1021/ja00166a043
- Boger, D. L., Jacobson, I. C. Studies of the total synthesis of fredericamycin-A - preparation of key partial structures and development of an intermolecular alkyne chromium carbene complex benzannulation cyclization approach to the ABCD(E) ring-system Journal of Organic Chemistry 1990 55:1919-1928 DOI:10.1021/jo00293a043
- Boger, D. L., Zarrinmayeh, H. Regiocontrolled nucleophilic-addition to selectively activated para-quinone diimines - alternative preparation of a key intermediate employed in the preparation of the CC-1065 left-hand subunit Journal of Organic Chemistry 1990 55:1379-1390 DOI:10.1021/jo00291a059
- Boger, D. L., Invergo, B. J., Coleman, R. S., Zarrinmayeh, H., Kitos, P. A., Thompson, S. C., Leong, T., McLaughlin, L. W. A demonstration of the intrinsic importance of stabilizing hydrophobic binding and noncovalent van der Waals contacts dominant in the noncovalent CC-1065/b-DNA binding Chemico-Biological Interactions 1990 73:29-52 DOI:10.1016/0009-2797(90)90107-x PMID:2406033
- Boger, D. L., Yohannes, D. Design and total synthesis of a conformational analog of bouvardin deoxybouvardin Synlett 1990 33-36
- Boger, D. L., Yohannes, D. Photolytic reactions of chromium aminocarbene complexes. Conversion of amides to α-amino acids Chemtracts: Organic Chemistry 1990 3:323-326
- Boger, D. L. Polyethylene-bound soluble recoverable palladium(0) catalysts Chemtracts: Organic Chemistry 1990 3:85-87
- Boger, D. L., Ishizaki, T. Resolution of a CBI precursor and incorporation into the synthesis of (+)-CBI, (+)-CBI-CDPI1, (+)-CBI-CDPI2 - enhanced functional analogs of (+)-CC-1065 - a critical-appraisal of a proposed relationship between electrophile reactivity, DNA-binding properties, and cytotoxic potency Tetrahedron Letters 1990 31:793-796 DOI:10.1016/s0040-4039(00)94629-x
- Boger, D. L., Coleman, R. S., Invergo, B. J., Sakya, S. M., Ishizaki, T., Munk, S. A., Zarrinmayeh, H., Kitos, P. A., Thompson, S. C. Synthesis and evaluation of aborted and extended CC-1065 functional analogs - (+)-CPI-PDE-1, and (-)-CPI-PDE-1, (+)-CPI-PDE-1, and (-)-CPI-CDPI1, and (+/-)-CPI-PDE-i1, (+)-CPI-PDE-i1, and (-)-CPI-CDPI3 - preparation of key partial structures and definition of an additional functional-role of the CC-1065 central and right-hand subunits Journal of the American Chemical Society 1990 112:4623-4632 DOI:10.1021/ja00168a002
- Boger, D. L. The absolute configuration and synthesis of natural (-)-dolastatin 10 Chemtracts: Organic Chemistry 1990 3:54-57
- Boger, D. L. Use of methylenecyclopropanone ketals for cyclopentane synthesis. A new efficient thermal [3 + 2] cycloaddition Chemtracts: Organic Chemistry 1990 3:47-50
- Boger, D. L., Ishizaki, T., Wysocki, R. J., Munk, S. A., Kitos, P. A., Suntornwat, O. Total synthesis and evaluation of (+/-)-N-(tert-butyloxycarbonyl)-CBI, (+/-)-CBI-CDPI1, and (+/-)-CBI-CDPI2 - CC-1065 functional agents incorporating the equivalent 1,2,9,9a-tetrahydrocycloprop 1,2-c benz 1,2-e indol-4-one (CBI) left-hand subunit Journal of the American Chemical Society 1989 111:6461-6463 DOI:10.1021/ja00198a089
- Boger, D. L., Yohannes, D. Total synthesis of K-13 Journal of Organic Chemistry 1989 54:2498-2502 DOI:10.1021/jo00272a003
- Boger, D. L., Wysocki, R. J. Total synthesis of (.+-.)-N-(phenylsulfonyl)- and (.+-.)-N-(tert-butyloxycarbonyl)-CI, (.+-.)-CI-CDPI1, and (.+-.)-CI-CDPI2: CC-1065 functional analogs incorporating the parent 1,2,7,7a-tetrahydrocycloprop[1,2-c]indol-4-one (CI) left-hand subunit Journal of Organic Chemistry 1989 54:1238-1240 DOI:10.1021/jo00267a004
- Boger, D. L., Kasper, A. M. A general-solution to implementing the 4-p participation of 1-aza-1,3-butadienes in Diels-Alder reactions - inverse electron demand Diels-Alder reactions of alpha,beta-unsaturated n-benzenesulfonyl imines Journal of the American Chemical Society 1989 111:1517-1519 DOI:10.1021/ja00186a067
- Boger, D. L., Wysocki, R. J. A study of the scope of the 4+2 cyclo-addition reactions of unactivated 1,3-oxazin-6-ones Journal of Organic Chemistry 1989 54:714-718 DOI:10.1021/jo00264a041
- Boger, D. L. Diels-Alder reactions of heterocyclic azadienes: development of a strategy for the total synthesis of streptonigrin, lavendamycin, and synthetic quinoline-5,8-quinones Strategies and Tactics in Organic Synthesis 1989 2:1-56 DOI:10.1016/B978-0-08-092429-8.50006-4
- Boger, D. L., Mathvink, R. J. Phenylselenoesters as effective precursors of acyl radicals for use in intermolecular alkene addition reactions Journal of Organic Chemistry 1989 54:1777-1779 DOI:10.1021/jo00269a001
- Boger, D. L., Patel, M. Recent applications of the inverse electron demand Diels-Alder reaction Progress in Heterocyclic Chemistry 1989 1:30-64
- Boger, D. L., Jacobson, I. C. Studies on the total synthesis of fredericamycin-a - development of an intermolecular alkyne-chromium carbene complex cyclization approach to the abcde ring-system Tetrahedron Letters 1989 30:2037-2040 DOI:10.1016/s0040-4039(01)93705-0
- Boger, D. L., Yohannes, D. Synthesis of isodityrosine Tetrahedron Letters 1989 30:2053-2056 DOI:10.1016/s0040-4039(01)93709-8
- Boger, D. L., Yohannes, D. Total synthesis of OF4949-III and OF4949-IV - unusual effects of remote substituents on the rate of macrocyclization reactions Tetrahedron Letters 1989 30:5061-5064 DOI:10.1016/s0040-4039(01)93447-1
- Boger, D. L., Cerbone, L. R., Yohannes, D. Oxidative coupling of methyl 6-hydroxyindole-2-carboxylate with primary amines - preparation of 2-substituted methyl pyrrolo 2,3-e benzoxazole-5-carboxylates Journal of Organic Chemistry 1988 53:5163-5166 DOI:10.1021/jo00256a053
- Boger, D. L., Wysocki, R. J. Thermal cyclo-addition reactions of pi-delocalized singlet vinylcarbenes - 3-carbon 1,1-dipoles/1,3-dipoles - the thermal 3-carbon + 2-carbon cyclo-addition Journal of Organic Chemistry 1988 53:3408-3421 DOI:10.1021/jo00250a002
- Boger, D. L., Mathvink, R. J. Acyl radicals: functionalized free radicals for intramolecular cyclization reactions Journal of Organic Chemistry 1988 53:3377-3379 DOI:10.1021/jo00249a053
- Boger, D. L., Coleman, R. S. Total synthesis of (+/-)-n-2-(phenylsulfonyl)-cpi, (+/-)-cc-1065, (+)-cc-1065, ent-(-)-cc-1065, and the precise, functional agents (+/-)-cpi-cdpi2, (+)-cpi-cdpi2, and (-)-cpi-cdpi2 (+/-)-(3br-star,4as-star)-deoxy-cc-1065, (+)-(3br,4as)-deoxy-cc-1065, and (-)-(3bs,4ar)-deoxy-cc-1065 Journal of the American Chemical Society 1988 110:4796-4807 DOI:10.1021/ja00222a043
- Boger, D. L., Sakya, S. M. Inverse electron demand Diels-Alder reactions of 3,6-bis(methylthio)-1,2,4,5-tetrazine - 1,2-diazine introduction and direct implementation of a divergent 1,2,4,5-tetrazine- 1,2-diazine- benzene (indoline indole) Diels-Alder strategy Journal of Organic Chemistry 1988 53:1415-1423 DOI:10.1021/jo00242a014
- Boger, D. L., Patel, M. Total synthesis of prodigiosin, prodigiosene, and desmethoxyprodigiosin - Diels-Alder reactions of heterocyclic azadienes and development of an effective palladium(II)-promoted 2,2'-bipyrrole coupling procedure Journal of Organic Chemistry 1988 53:1405-1415 DOI:10.1021/jo00242a013
- Boger, D. L., Yohannes, D. Studies on the total synthesis of bouvardin and deoxybouvardin - cyclic hexapeptide cyclization studies and preparation of key partial structures Journal of Organic Chemistry 1988 53:487-499 DOI:10.1021/jo00238a005
- Boger, D. L., Coleman, R. S. Total synthesis of (+)CPI-CDPI2 and (-)-CPI-CDPI2 - (+)-(3br,4as)-deoxy-CC-1065 and (-)-(3bs,4ar)-deoxy-CC-1065 Journal of Organic Chemistry 1988 53:695-698 DOI:10.1021/jo00238a042
- Boger, D. L., Robarge, K. D. A divergent de novo synthesis of carbohydrates based on an accelerated inverse electron demand Diels-Alder reaction of 1-oxa-1,3-butadienes Journal of Organic Chemistry 1988 53:5793-5796 DOI:10.1021/jo00259a040
- Boger, D. L., Robarge, K. D. Accelerated inverse electron demand Diels-Alder reactions of 1-oxa-1,3-butadienes: [4 + 2] cycloaddition reactions of beta,gamma-unsaturated alpha-keto esters Journal of Organic Chemistry 1988 53:3373-3377 DOI:10.1021/jo00249a052
- Boger, D. L., Dang, Q. Inverse electron demand Diels-Alder reactions of 2,4,6-tris(ethoxycarbonyl)-1,3,5-triazine and 2,4,6-tris(methylthio)-1,3,5-triazine - pyrimidine introduction Tetrahedron 1988 44:3379-3390 DOI:10.1016/s0040-4020(01)85973-1
- Boger, D. L., Panek, J. S., Yasuda, M. Preparation and inverse electron demand Diels-Alder reaction of an electron-deficient heterocyclic azadiene - triethyl 1,2,4-triazine-3,5,6-tricarboxylate Organic Syntheses 1988 66:142-149
- Boger, D. L., Panek, J. S., Yasuda, M. Preparation and inverse-electron-demand Diels-Alder reaction of an electron-deficient heterocyclic azadiene: triethyl 1,2,4-triazine-3,5,6-tricarboxylate and 2,3,6-tricarboethoxypyridine Organic Syntheses 1988 66:142-149
- Boger, D. L., Coleman, R. S. Total synthesis of (+)-CC-1065 and ent-(-)-CC-1065 Journal of the American Chemical Society 1988 110:1321-1323 DOI:10.1021/ja00212a067
- Boger, D. L., Yohannes, D. Selectively protected L-dopa derivatives - application of the benzylic hydroperoxide rearrangement Journal of Organic Chemistry 1987 52:5283-5286 DOI:10.1021/jo00232a044
- Boger, D. L., Yasuda, M., Mitscher, L. A., Drake, S. D., Kitos, P. A., Thompson, S. C. Streptonigrin and lavendamycin partial structures - probes for the minimum, potent pharmacophore of streptonigrin, lavendamycin, and synthetic quinoline-5,8-diones Journal of Medicinal Chemistry 1987 30:1918-1928 DOI:10.1021/jm00393a040 PMID:3656364
- Yasuda, M., Boger, D. L. Streptonigrin and lavendamycin partial structures. Preparation of 7-amino-2-(2′-pyridyl)quinoline-5,8-quinone-6′-carboxylic acid: a probe for the minimum, potent pharmacophore of the naturally occurring antitumor-antibiotics Journal of Heterocyclic Chemistry 1987 24:1253-1260 DOI:10.1002/jhet.5570240504
- Boger, D. L., Patel, M. Indole N-carbonyl compounds - preparation and coupling of indole-1-carboxylic acid anhydride Journal of Organic Chemistry 1987 52:3934-3936 DOI:10.1021/jo00226a044
- Boger, D. L., Patel, M. Activation and coupling of pyrrole-1-carboxylic acid in the formation of pyrrole N-carbonyl compounds - pyrrole-1-carboxylic acid anhydride Journal of Organic Chemistry 1987 52:2319-2323 DOI:10.1021/jo00387a046
- Boger, D. L., Coleman, R. S. Diels-alder reactions of heterocyclic azadienes - total synthesis of pde-i, pde-ii, and pde-i dimer methyl-ester Journal of the American Chemical Society 1987 109:2717-2727 DOI:10.1021/ja00243a027
- Boger, D. L., Coleman, R. S., Invergo, B. J. Studies on the total synthesis of CC-1065 - preparation of a synthetic, simplified 3-carbamoyl-1,2-dihydro-3h-pyrrolo 3,2-e indole dimer/trimer/tetramer (CDPI dimer/trimer/tetramer) and development of methodology for PDE-I dimer methyl-ester formation Journal of Organic Chemistry 1987 52:1521-1530 DOI:10.1021/jo00384a026
- Boger, D. L., Coleman, R. S. Further observations on the Lewis acid-catalyzed benzylic hydroperoxide rearrangement - use of a boron-trifluoride hydrogen-peroxide preformed, aged reagent Tetrahedron Letters 1987 28:1027-1030 DOI:10.1016/s0040-4039(00)95902-1
- Boger, D. L., Mullican, M. D. Preparation and inverse electron demand Diels-Alder reaction of an electron-deficient diene: methyl 2-oxo-5,6,7,8-tetrahydro-2H-1-benzopyran-3-carboxylate (2H-1-benzopyran-3-carboxylic acid, 5,6,7,8-tetrahydro-2-oxo-, methyl ester) Organic Syntheses 1987 65:98-107
- Boger, D. L., Brotherton, C. E., Georg, G. I. Preparation and three-carbon + two-carbon cycloaddition of a cyclopropenone ketal: cyclopropenone 1,3-propanediol ketal (4,8-dioxaspiro[2.5]oct-1-ene) Organic Syntheses 1987 65:32-41
- Boger, D. L., Patel, M. Total synthesis of prodigiosin Tetrahedron Letters 1987 28:2499-2502 DOI:10.1016/s0040-4039(00)95451-0
- Boger, D. L., Coleman, R. S. Benzylic hydroperoxide rearrangement - observations on a viable and convenient alternative to the Baeyer Villiger rearrangement Journal of Organic Chemistry 1986 51:5436-5439 DOI:10.1021/jo00376a079
- Boger, D. L., Brotherton, C. E. Thermal-reactions of cyclopropenone ketals - application of the cycloaddition reactions of delocalized singlet vinylcarbenes - 3-carbon 1,1-dipoles 1,3-dipoles - an alternative synthesis of deacetamidocolchiceine - formal total synthesis of colchicine Journal of the American Chemical Society 1986 108:6713-6719 DOI:10.1021/ja00281a042
- Boger, D. L., Brotherton, C. E. Thermal-reactions of cyclopropenone ketals - key mechanistic features and scope of the cycloaddition reactions of delocalized singlet vinylcarbenes - 3-carbon 1,1-dipoles 1,3-dipoles Journal of the American Chemical Society 1986 108:6695-6713 DOI:10.1021/ja00281a041
- Boger, D. L. Diels-Alder reactions of heterocyclic azadienes: scope and applications Chemical Reviews 1986 86:781-793 DOI:10.1021/cr00075a004
- Boger, D. L., Coleman, R. S. Diels-Alder reactions of heterocyclic azadienes: total synthesis of PDE-II methyl ester Journal of Organic Chemistry 1986 51:3250-3252 DOI:10.1021/jo00366a048
- Boger, D. L., Yasuda, M. An improved and divergent introduction of the streptonigrin and lavendamycin quinoline-5,8-quinone AB ring-systems Heterocycles 1986 24:1067-1073 DOI:10.3987/R-1986-04-1067
- Boger, D. L., Brotherton, C. E. Diels-Alder cycloaddition reactions of cyclopropenone ketals: dual participation in inverse electron demand (LUMOdiene controlled) and normal HOMOdiene controlled) Diels-Alder reactions, approaches to the preparation of tropones Tetrahedron 1986 42:2777-2785 DOI:10.1016/s0040-4020(01)90567-8
- Boger, D. L., Patel, M. Diels-Alder cycloadditions of rigid dienophiles: a probe for allylic axial substituent control of the pi-facial selectivity in the Diels-Alder reaction Tetrahedron Letters 1986 27:683-686 DOI:10.1016/s0040-4039(00)84072-1
- Boger, D. L., Duff, S. R., Panek, J. S., Yasuda, M. Inverse electron demand Diels-Alder reactions of heterocyclic aza dienes - studies on the total synthesis of lavendamycin - investigative studies on the preparation of the CDE beta-carboline ring-system and AB quinoline-5,8-quinone ring-system Journal of Organic Chemistry 1985 50:5782-5789 DOI:10.1021/jo00350a069
- Boger, D. L., Duff, S. R., Panek, J. S., Yasuda, M. Total synthesis of lavendamycin methyl-ester Journal of Organic Chemistry 1985 50:5790-5795 DOI:10.1021/jo00350a070
- Boger, D. L., Coleman, R. S., Panek, J. S., Huber, F. X. A detailed, convenient preparation of dimethyl "1,2,4,5-tetrazine-3,6-dicarboxylate Journal of Organic Chemistry 1985 50:5377-5379 DOI:10.1021/jo00225a076
- Boger, D. L., Mitscher, L. A., Mullican, M. D., Drake, S. D., Kitos, P. Antimicrobial and cytotoxic properties of 9,10-dihydrophenanthrenes: structure activity studies on juncusol Journal of Medicinal Chemistry 1985 28:1543-1547 DOI:10.1021/jm00148a031 PMID:4045930
- Boger, D. L., Panek, J. S. Inverse electron demand Diels-Alder reactions of heterocyclic azadienes - formal total synthesis of streptonigrin Journal of the American Chemical Society 1985 107:5745-5754 DOI:10.1021/ja00306a024
- Boger, D. L., Mullican, M. D., Hellberg, M. R., Patel, M. Preparation of optically-active, functionalized cis-delta-6-1-octalones Journal of Organic Chemistry 1985 50:1904-1911 DOI:10.1021/jo00211a024
- Boger, D. L., Patel, M., Takusagawa, F. Regioselectivity of the intermolecular Diels-Alder reaction of acyl nitroso-compounds (C-nitrosocarbonyl compounds) and nitrosoformates (O-nitrosocarbonyl compounds) - preparation of functionalized cis-delta-6-1-octalones Journal of Organic Chemistry 1985 50:1911-1916 DOI:10.1021/jo00211a025
- Boger, D. L., Brotherton, C. E. Thermal, four-carbon + three-carbon cycloaddition reaction of cyclopropenone ketals. Total synthesis of deacetamidocolchiceine: formal total synthesis of colchicine Journal of Organic Chemistry 1985 50:3425-3427 DOI:10.1021/jo00218a042
- Boger, D. L., Brotherton, C. E., Panek, J. S., Yohannes, D. Direct introduction of nitriles via use of unstable reissert intermediates - convenient procedures for the preparation of 2-cyanoquinolines and 1-cyanoisoquinolines Journal of Organic Chemistry 1984 49:4056-4058 DOI:10.1021/jo00195a036
- Boger, D. L., Brotherton, C. E. Effective, thermal 3-carbon + 2-carbon cycloaddition for cyclopentenone formation - formal 1,3-dipolar cycloaddition of cyclopropenone ketals Journal of the American Chemical Society 1984 106:805-807 DOI:10.1021/ja00315a065
- Boger, D. L., Brotherton, C. E. Effective, thermal one-carbon + 2-carbon cycloaddition of cyclopropenone ketals with electron deficient olefins - cyclopropane formation Tetrahedron Letters 1984 25:5611-5614 DOI:10.1016/s0040-4039(01)91393-0
- Boger, D. L., Coleman, R. S. Intramolecular diels-alder reactions of 1,2-diazines - general indoline synthesis - studies on the preparation of the central and right-hand segments of cc-1065 Journal of Organic Chemistry 1984 49:2240-2245 DOI:10.1021/jo00186a032
- Boger, D. L., Mullican, M. D. Inverse electron demand Diels-Alder reactions of 3-carbomethoxy-2-pyrones - controlled introduction of oxygenated aromatics - benzene, phenol, catechol, resorcinol, and pyrogallol annulation - regiospecific total synthesis of sendaverine and a preparation of 6,7-benzomorphans Journal of Organic Chemistry 1984 49:4033-4044 DOI:10.1021/jo00195a033
- Boger, D. L., Panek, J. S. Palladium (0) mediated beta-carboline synthesis - preparation of the CDE ring-system of lavendamycin Tetrahedron Letters 1984 25:3175-3178
- Boger, D. L., Patel, M. Regioselectivity in the intermolecular Diels-Alder reaction of acyl nitroso compounds (C-nitrosocarbonyl compounds) and nitrosoformates (O-nitrosocarbonyl compounds) Journal of Organic Chemistry 1984 49:4098-4099 DOI:10.1021/jo00195a057
- Boger, D. L., Mullican, M. D. Regiospecific total synthesis of juncusol Journal of Organic Chemistry 1984 49:4045-4050 DOI:10.1021/jo00195a034
- Boger, D. L., Coleman, R. S., Panek, J. S., Yohannes, D. Thermal cycloaddition of dimethyl "1,2,4,5-tetrazine-3,6-dicarboxylate with electron-rich olefins - 1,2-diazine and pyrrole introduction - preparation of octamethylporphin (OMP) Journal of Organic Chemistry 1984 49:4405-4409 DOI:10.1021/jo00197a015
- Boger, D. L., Brotherton, C. E., Georg, G. I. Thermal, 3-carbon + 2-atom cycloaddition of cyclopropenone ketals with carbon-heteroatom double-bonds - butenolide, furan, and gamma-keto ester preparation Tetrahedron Letters 1984 25:5615-5618 DOI:10.1016/s0040-4039(01)91394-2
- Boger, D. L., Brotherton, C. E. Total syntheses of azafluoranthene alkaloids: rufescine and imeluteine Journal of Organic Chemistry 1984 49:4050-4055 DOI:10.1021/jo00195a035
- Boger, D. L., Panek, J. S. 1,2,4-triazine preparation via thermal cycloaddition of dimethyl 1,2,4,5-tetrazine-3,6-dicarboxylate with aryl thioimidates Tetrahedron Letters 1983 24:4511-4514 DOI:10.1016/s0040-4039(00)85941-9
- Boger, D. L. Diels-Alder reactions of azadienes Tetrahedron 1983 39:2869-2939 DOI:10.1016/s0040-4020(01)92154-4
- Boger, D. L., Panek, J. S. Formal total synthesis of streptonigrin Journal of Organic Chemistry 1983 48:621-623 DOI:10.1021/jo00152a049
- Boger, D. L., Mullican, M. D. Inverse electron demand Diels-Alder reactions of 3-carbomethoxy-2-pyrones - controlled introduction of oxygenated aromatics - benzene, phenol, catechol, resorcinol, pyrogallol annulation Tetrahedron Letters 1983 24:4939-4942 DOI:10.1016/s0040-4039(01)99816-8
- Boger, D. L., Panek, J. S., Meier, M. M. Diels-Alder reaction of heterocyclic azadienes. 2. Catalytic Diels-Alder reaction of in situ generated enamines with 1,2,4-triazines: general pyridine annulation Journal of Organic Chemistry 1982 47:895-897 DOI:10.1021/jo00344a031
- Boger, D. L., Mullican, M. D. Inverse electron demand diels-alder reaction of 3-carbomethoxy-2-pyrones with 1,1-dimethoxyethylene - a simple and mild method of aryl annulation Tetrahedron Letters 1982 23:4551-4554 DOI:10.1016/s0040-4039(00)85651-8
- Boger, D. L., Panek, J. S. Pyridine construction via thermal cycloaddition of 1,2,4-triazines with enamines - studies on the preparation of the bi-aryl CD rings of streptonigrin Journal of Organic Chemistry 1982 47:3763-3765 DOI:10.1021/jo00140a035
- Boger, D. L., Mullican, M. D. Regiospecific total synthesis of juncusol Tetrahedron Letters 1982 23:4555-4558 DOI:10.1016/s0040-4039(00)85652-x
- Boger, D. L., Patel, M., Mullican, M. D. Synthetic analgesics - preparation of racemic 6,7-benzomorphans Tetrahedron Letters 1982 23:4559-4562 DOI:10.1016/s0040-4039(00)85653-1
- Boger, D. L., Schumacher, J., Mullican, M. D., Patel, M., Panek, J. S. Thermal cycloaddition of 1,3,5-triazine with enamines - regiospecific pyrimidine annulation Journal of Organic Chemistry 1982 47:2673-2675 DOI:10.1021/jo00134a034
- Boger, D. L., Brotherton, C. E., Kelley, M. D. A simplified isoquinoline synthesis Tetrahedron 1981 37:3977-3980 DOI:10.1016/s0040-4020(01)93272-7
- Boger, D. L., Panek, J. S. Diels-alder reaction of heterocyclic azadienes .1. Thermal cycloaddition of 1,2,4-triazine with enamines - simple preparation of substituted pyridines Journal of Organic Chemistry 1981 46:2179-2182 DOI:10.1021/jo00323a044
- Boger, D. L., Panek, J. S. Preparation of (R)-(+) and (S)-(-)-4-iodo-1,2-epoxybutane (R)-(2-iodoethyl)oxirane and (S)-(2-iodoethyl)oxirane , useful chiral synthons Journal of Organic Chemistry 1981 46:1208-1210 DOI:10.1021/jo00319a034
- Boger, D. L., Brotherton, C. E. Preparation of 3-methyl-4-vinyl-1,2,5-oxadiazole and 3-methyl-4-vinyl-1,2,5-thiadiazole Journal of Heterocyclic Chemistry 1981 18:1247-1249 DOI:10.1002/jhet.5570180636
- Boger, D. L., Mullican, M. D. A simple and convenient phenol annelation Journal of Organic Chemistry 1980 45:5002-5004 DOI:10.1021/jo01312a044
- Corey, E. J., Boger, D. L. Application of benzothiazoles to carbon-carbon bond formation in organic-synthesis Tetrahedron Letters 1978 9-12
- Corey, E. J., Boger, D. L. Benzothiazoles as carbonyl equivalents Tetrahedron Letters 1978 5-8
- Boger, D. L. Concerning the stereochemistry of 9-methyl-Δ1-3-octalone Tetrahedron Letters 1978 17-18 DOI:10.1016/S0040-4039(01)88970-X
- Boger, D. L. Convenient preparation of 2-substituted benzothiazoles Journal of Organic Chemistry 1978 43:2296-2297 DOI:10.1021/jo00405a050
- Corey, E. J., Boger, D. L. New and unusually flexible scheme for annulation to form fused cyclohexenone units Tetrahedron Letters 1978 4597-4600 DOI:10.1016/S0040-4039(01)85680-X
- Corey, E. J., Boger, D. L. New annulation processes for fused and spiro rings based on chemistry of benzothiazoles Tetrahedron Letters 1978 13-16
- Corey, E. J., Boger, D. L. Oxidative cationic cyclization reactions effected by pyridinium chlorochromate Tetrahedron Letters 1978 2461-2464 DOI:10.1016/S0040-4039(01)94800-2
- Burgstahler, A. W., Boger, D. L., Naik, N. C. Synthesis and chiroptical properties of some asymmetric planar cisoid dienes Tetrahedron 1976 32:309-315 DOI:10.1016/0040-4020(76)80042-7
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report
- Dreyton, C. J., Jones, J. E., Knuckley, B. A., Subramanian, V., Anderson, E. D., Brown, S. J., Fernandez-Vega, V., Eberhart, C., Spicer, T., Zuhl, A. M., Ferguson, J., Speers, A. E., et al. Optimization and characterization of a pan protein arginine deiminase (PAD) inhibitor Probe Reports from the NIH Molecular Libraries Program. 2010 PMID:23833800
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thesis