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Boger, Dale
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Boger, Dale

Richard and Alice Cramer Professor of Chemistry
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Positions

  • 1996 - Member, The Skaggs Institute for Chemical Biology , Scripps Research
  • 1991 - Professor, Chemistry , Scripps Research
  • 1991 - Faculty Member, Skaggs Graduate School of Chemical and Biological Sciences , Scripps Research
  • Richard and Alice Cramer Professor of Chemistry, Chemistry , Scripps Research
  • 2017 - 2018 co-Chair, Chemistry , Scripps Research
  • 2013 - 2017 Chairman, Chemistry , Scripps Research
  • 1985 - 1991 Associate Professor / Professor of Chemistry, Purdue University
  • 1979 - 1985 Assistant Professor / Associate Professor of Medicinal Chemistry, The University of Kansas
Dr. Dale Boger works on the total synthesis of biologically active natural products using the tools of organic synthesis to identify, imitate, understand, exploit, and sometimes surpass what nature provides.

Research Areas research areas

  • neoplasms (UMLS)

Contact

  • boger@scripps.edu

Websites

  • Dale Boger, Ph.D.
  • Boger Laboratory
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Publications

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    • Angelbello, A. J., Defeo, M. E., Glinkerman, C. M., Boger, D. L., Disney, M. D. Precise Targeted Cleavage of a r(CUG) Repeat Expansion in Cells by Using a Small-Molecule-Deglycobleomycin Conjugate ACS Chemical Biology  2020 15:849-855  DOI:10.1021/acschembio.0c00036  PMCID:32186845
    • Wu, Z. C., Isley, N. A., Okano, A., Weiss, W. J., Boger, D. L. C1-CBP-vancomycin: Impact of a vancomycin C-terminus trimethylammonium cation on pharmacological properties and insights into its newly introduced mechanism of action Journal of Organic Chemistry  2020 85:1365-1375  DOI:10.1021/acs.joc.9b02314  PMID:31670958  PMCID:PMC7007832
    • Moore, M. J., Qu, S. W., Tan, C. H., Cai, Y., Mogi, Y., Keith, D. J., Boger, D. L. Next-Generation Total Synthesis of Vancomycin Journal of the American Chemical Society  2020 142:16039-16050  DOI:10.1021/jacs.0c07433  PMID:32885969  PMCID:PMC7501256
    • Wu, Z. C., Cameron, M. D., Boger, D. L. Vancomycin C-Terminus Guanidine Modifications and Further Insights into an Added Mechanism of Action Imparted by a Peripheral Structural Modification ACS Infectious Diseases  2020 6:2169-2180  DOI:10.1021/acsinfecdis.0c00258  PMID:32598127  PMCID:PMC7429263
    • Beekman, A. M., Cominetti, M. M. D., Cartwright, O. C., Boger, D. L., Searcey, M. A small molecule drug conjugate (SMDC) of DUPA and a duocarmycin built on the solid phase MedChemComm  2019 10:2170-2174  DOI:10.1039/c9md00279k
    • Plewe, M. B., Whitby, L. R., Naik, S., Brown, E. R., Sokolova, N. V., Gantla, V. R., York, J., Nunberg, J. H., Zhang, L., Kalveram, B., Freiberg, A. N., Boger, D. L., et al. SAR studies of 4-acyl-1,6-dialkylpiperazin-2-one arenavirus cell entry inhibitors Bioorganic & Medicinal Chemistry Letters  2019 29  DOI:10.1016/j.bmcl.2019.08.024  PMID:31537423  PMCID:PMC6803051
    • Isley, N. A., Endo, Y., Wu, Z. C., Covington, B. C., Bushin, L. B., Seyedsayamdost, M. R., Boger, D. L. Total synthesis and stereochemical assignment of streptide Journal of the American Chemical Society  2019 141:17361-17369  DOI:10.1021/jacs.9b09067  PMID:31577142  PMCID:PMC6821584
    • Ozog, S., Timberlake, N. D., Hermann, K., Garijo, O., Haworth, K. G., Shi, G., Glinkerman, C. M., Schefter, L. E., D'Souza, S., Simpson, E., Sghia-Hughes, G., Carillo, R. R., et al. Resveratrol trimer enhances gene delivery to hematopoietic stem cells by reducing antiviral restriction at endosomes Blood  2019 134:1298-1311  DOI:10.1182/blood.2019000040  PMID:31416800
    • Boon, B. A., Boger, D. L. Triarylaminium radical cation promoted coupling of catharanthine with vindoline: diastereospecific synthesis of anhydrovinblastine and reaction scope Journal of the American Chemical Society  2019 141:14349-14355  DOI:10.1021/jacs.9b06968  PMID:31442047  PMCID:PMC6750708
    • Wu, Z. C., Boger, D. L. Exploration of the site-specific nature and generalizability of a trimethylammonium salt modification on vancomycin: A-ring derivatives Tetrahedron  2019 75:3160-3165  DOI:10.1016/j.tet.2019.02.008
    • Radakovic, A., Boger, D. L. Ultra-potent vinblastine analogues improve on-target activity of the parent microtubulin-targeting compound Bioorganic & Medicinal Chemistry Letters  2019 29:1370-1374  DOI:10.1016/j.bmcl.2019.03.036  PMID:30952593  PMCID:PMC6487230
    • Otrubova, K., Chatterjee, S., Ghimire, S., Cravatt, B. F., Boger, D. L. N-acyl pyrazoles: effective and tunable inhibitors of serine hydrolases Bioorganic & Medicinal Chemistry  2019 27:1693-1703  DOI:10.1016/j.bmc.2019.03.020  PMID:30879861
    • Su, L., Wang, Y., Wang, J., Mifune, Y., Morin, M. D., Jones, B. T., Moresco, E. M. Y., Boger, D. L., Beutler, B., Zhang, H. Structural basis of TLR2/TLR1 activation by the synthetic agonist diprovocim Journal of Medicinal Chemistry  2019 62:2938-2949  DOI:10.1021/acs.jmedchem.8b01583  PMID:30829478
    • Zhang, J., Shukla, V., Boger, D. L. Inverse electron demand Diels-Alder reactions of heterocyclic azadienes, 1-aza-1,3-butadienes, cyclopropenone ketals and related systems. A retrospective Journal of Organic Chemistry  2019  DOI:10.1021/acs.joc.9b00834
    • Morin, M. D., Wang, Y., Jones, B. T., Mifune, Y., Su, L., Shi, H., Moresco, E. M. Y., Zhang, H., Beutler, B., Boger, D. L. Diprovocims: A new and exceptionally potent class of toll-like receptor agonists Journal of the American Chemical Society  2018 140:14440-14454  DOI:10.1021/jacs.8b09223  PMID:30272974  PMCID:PMC6209530
    • Wu, Z. C., Isley, N. A., Boger, D. L. N-terminus alkylation of vancomycin: ligand binding affinity, antimicrobial activity, and site-specific nature of quaternary trimethylammonium salt modification ACS Infectious Diseases  2018 4:1468-1474  DOI:10.1021/acsinfecdis.8b00152  PMID:30067012  PMCID:PMC6200594
    • Wang, Y., Su, L., Morin, M. D., Jones, B. T., Mifune, Y., Shi, H., Wang, K., Zhan, X., Liu, A., Wang, J., Li, X., Tang, M., et al. Adjuvant effect of the novel TLR1/TLR2 agonist Diprovocim synergizes with anti-PD-L1 to eliminate melanoma in mice Proceedings of the National Academy of Sciences of the United States of America  2018 115:E8698-E8706  DOI:10.1073/pnas.1809232115  PMID:30150374  PMCID:PMC6140543
    • Boyle, K. E., Boger, D. L., Wroe, A., Vazquez, M. Duocarmycin SA, a potent antitumor antibiotic, sensitizes glioblastoma cells to proton radiation Bioorganic & Medicinal Chemistry Letters  2018 28:2688-2692  DOI:10.1016/j.bmcl.2018.04.008  PMID:29650288
    • Glinkerman, C. M., Boger, D. L. Synthesis, characterization, and rapid cycloadditions of 5-nitro-1,2,3-triazine Organic Letters  2018 20:2628-2631  DOI:10.1021/acs.orglett.8b00825  PMID:29659291  PMCID:PMC5935562
    • Radakovic, A., Boger, D. L. High expression of class III β-tubulin has no impact on functional cancer cell growth inhibition of a series of key vinblastine analogs Bioorganic & Medicinal Chemistry Letters  2018 28:863-865  DOI:10.1016/j.bmcl.2018.02.006  PMID:29439899  PMCID:PMC5835219
    • Boger, D. L. The difference a single atom can make: synthesis and design at the chemistry-biology interface Journal of Organic Chemistry  2017 82:11961-11980  DOI:10.1021/acs.joc.7b02088  PMID:28945374  PMCID:PMC5712263
    • Okano, A., Isley, N. A., Boger, D. L. Total syntheses of vancomycin-related glycopeptide antibiotics and key analogues Chemical Reviews  2017 117:11952-11993  DOI:10.1021/acs.chemrev.6b00820  PMID:28437097  PMCID:PMC5617763
    • Quinones, R. E., Glinkerman, C. M., Zhu, K., Boger, D. L. Direct synthesis of β-aminoenals through reaction of 1,2,3-triazine with secondary amines Organic Letters  2017 19:3568-3571  DOI:10.1021/acs.orglett.7b01543  PMID:28657329
    • Okano, A., Isley, N. A., Boger, D. L. Peripheral modifications of [Ψ[CH2NH]Tpg4]vancomycin with added synergistic mechanisms of action provide durable and potent antibiotics Proceedings of the National Academy of Sciences of the United States of America  2017 114:E5052-E5061  DOI:10.1073/pnas.1704125114  PMID:28559345  PMCID:PMC5495262
    • Kornahrens, A. F., Cognetta III, A. B., Brody, D. M., Matthews, M. L., Cravatt, B. F., Boger, D. L. Design of benzoxathiazin-3-one 1,1-dioxides as a new class of irreversible serine hydrolase inhibitors: Discovery of a uniquely selective PNPLA4 inhibitor Journal of the American Chemical Society  2017 139:7052-7061  DOI:10.1021/jacs.7602985  PMID:28498651
    • Yang, S., Sankar, K., Skepper, C. K., Barker, T. J., Lukesh, J. C., Brody, D. M., Brutsch, M. M., Boger, D. L. Total synthesis of a key series of vinblastines modified at C4 that define the importance and surprising trends in activity Chemical Science  2017 8:1560-1569  DOI:10.1039/c6sc04146a  PMID:28194270  PMCID:PMC5302862
    • Lukesh III, J. C., Carney, D. W., Dong, H. J., Cross, R. M., Shukla, V., Duncan, K. K., Yang, S. L., Brody, D. M., Brutsch, M. M., Radakovic, A., Boger, D. L. Vinblastine 20 ' amides: synthetic analogues that maintain or improve potency and simultaneously overcome Pgp-derived efflux and resistance Journal of Medicinal Chemistry  2017 60:7591-7604  DOI:10.1021/acs.jmedchem.7b00958  PMID:28857558  PMCID:PMC5599373
    • Chanda, P. B., Boyle, K. E., Brody, D. A., Shukla, V., Boger, D. L. Synthesis and evaluation of duocarmycin SA analogs incorporating the methyl 1,2,8,8a-tetrahydrocyclopropa c imidazolo 4,5-e indol-4-one-6-carboxylat e (CImI) alkylation subunit Bioorganic & Medicinal Chemistry  2016 24:4779-4786  DOI:10.1016/j.bmc.2016.04.050  PMID:27221071  PMCID:PMC5052114
    • Glinkerman, C. M., Boger, D. L. Catalysis of heterocyclic azadiene cycloaddition reactions by solvent hydrogen bonding: concise total synthesis of methoxatin Journal of the American Chemical Society  2016 138:12408-12413  DOI:10.1021/jacs.6b05438  PMID:27571404  PMCID:PMC5042865
    • Carney, D. W., Lukesh III, J. C., Brody, D. M., Brutsch, M. M., Boger, D. L. Ultrapotent vinblastines in which added molecular complexity further disrupts the target tubulin dimer-dimer interface Proceedings of the National Academy of Sciences of the United States of America  2016 113:9691-9698  DOI:10.1073/pnas.1611405113  PMID:27512044  PMCID:PMC5024590
    • Shankar, S., Whitby, L. R., Casquilho-Gray, H. E., York, J., Boger, D. L., Nunberg, J. H. Small-molecule fusion inhibitors bind the pH-sensing stable signal peptide-GP2 subunit interface of the Lassa virus Envelope glycoprotein Journal of Virology  2016 90:6799-6807  DOI:10.1128/jvi.00597-16  PMID:27194767  PMCID:PMC4944282
    • Burman, M. A., Szolusha, K., Bind, R., Kerney, K., Boger, D. L., Bilsky, E. J. FAAH inhibitor OL-135 disrupts contextual, but not auditory, fear conditioning in rats Behavioural Brain Research  2016 308:1-5  DOI:10.1016/j.bbr.2016.04.014  PMID:27083303  PMCID:PMC4877211
    • Allemann, O., Brutsch, M., Lukesh III, J. C., Brody, D. M., Boger, D. L. Synthesis of a potent vinblastine: rationally designed added benign complexity Journal of the American Chemical Society  2016 138:8376-8379  DOI:10.1021/jacs.6b04330  PMID:27356080  PMCID:PMC4945418
    • Morin, M. D., Wang, Y., Jones, B. T., Su, L., Surakattula, M. M. R. P., Berger, M., Huang, H., Beutler, E. K., Zhang, H., Beutler, B., Boger, D. L. Discovery and structure-activity relationships of the neoseptins: a new class of toll-like receptor-4 (TLR4) agonists Journal of Medicinal Chemistry  2016 59:4812-4830  DOI:10.1021/acs.jmedchem.6b00177  PMID:27050713  PMCID:PMC4882283
    • Sears, J. E., Boger, D. L. Tandem intramolecular Diels-Alder/1,3-dipolar cycloaddition cascade of 1,3,4-oxadiazoles: initial scope and applications Accounts of Chemical Research  2016 49:241-251  DOI:10.1021/acs.accounts.5b00510  PMID:26813287  PMCID:PMC4755904
    • Wang, Y., Su, L., Morin, M. D., Jones, B. T., Whitby, L. R., Surakattula, M. M. R. P., Huang, H., Shi, H., Choi, J. H., Wang, K. W., Moresco, E. M. Y., Berger, M., et al. TLR4/MD-2 activation by a synthetic agonist with no similarity to LPS Proceedings of the National Academy of Sciences of the United States of America  2016 113:E884-E893  DOI:10.1073/pnas.1525639113  PMID:26831104  PMCID:PMC4763747
    • Janssen, F. J., Baggelaar, M. P., Hummel, J. J. A., Overkleeft, H. S., Cravatt, B. F., Boger, D. L., van der Stelt, M. Comprehensive analysis of structure-activity relationships of a-ketoheterocycles as sn-1-diacylglycerol lipase a inhibitors Journal of Medicinal Chemistry  2015 58:9742-9753  DOI:10.1021/acs.jmedchem.5b01627  PMID:26584396  PMCID:PMC4690813
    • Sears, J. E., Barker, T. J., Boger, D. L. Total synthesis of (-)-vindoline and (+)-4-epi-vindoline based on a 1,3,4-oxadiazole tandem intramolecular 4+2 / 3+2 cycloaddition cascade initiated by an allene dienophile Organic Letters  2015 17:5460-5463  DOI:10.1021/acs.orglett.5b02818  PMID:26457536  PMCID:PMC4636949
    • Boger, D. L. When sugar is not so sweet Science  2015 350:275-276  DOI:10.1126/science.aad3298
    • Lee, K., Poudel, Y. B., Glinkerman, C. M., Boger, D. L. Total synthesis of dihydrolysergic acid and dihydrolysergol: development of a divergent synthetic strategy applicable to rapid assembly of D-ring analogs Tetrahedron  2015 71:5897-5905  DOI:10.1016/j.tet.2015.05.093  PMID:26273113  PMCID:PMC4528678
    • Glinkerman, C. M., Boger, D. L. Cycloadditions of 1,2,3-triazines bearing C5-electron donating substituents: robust pyrimidine synthesis Organic Letters  2015 17:4002-4005  DOI:10.1021/acs.orglett.5b01870  PMID:26172042  PMCID:PMC4546508
    • Uematsu, M., Brody, D. M., Boger, D. L. A five-membered lactone prodrug of CBI-based analogs of the duocarmycins Tetrahedron Letters  2015 56:3101-3104  DOI:10.1016/j.tetlet.2014.11.038  PMID:26069351  PMCID:PMC4459655
    • Lee, K., Boger, D. L. Total synthesis of (-)-kopsinine and ent-(+)-kopsinine Tetrahedron  2015 71:3741-3746  DOI:10.1016/j.tet.2014.07.094  PMID:26074629  PMCID:PMC4461145
    • Okano, A., Nakayama, A., Wu, K., Lindsey, E. A., Schammel, A. W., Feng, Y., Collins, K. C., Boger, D. L. Total syntheses and initial evaluation of [?[C(-S)NH]Tpg(4)]vancomycin, [?[C(-NH)NH]Tpg(4)]vancomycin, [?[CH2NH]Tpg(4)]vancomycin, and their (4-Chlorobiphenyl)methyl derivatives: synergistic binding pocket and peripheral modifications for the glycopeptide antibiotics Journal of the American Chemical Society  2015 137:3693-3704  DOI:10.1021/jacs.5b01008  PMID:25750995  PMCID:PMC4376669
    • Sears, J. E., Boger, D. L. Total synthesis of vinblastine, related natural products, and key analogues and development of inspired methodology suitable for the systematic study of their structure-function properties Accounts of Chemical Research  2015 48:653-662  DOI:10.1021/ar500400w  PMID:25586069  PMCID:PMC4363169
    • Zhao, N., Darby, C. M., Small, J., Bachovchin, D. A., Jiang, X., Burns-Huang, K. E., Botella, H., Ehrt, S., Boger, D. L., Anderson, E. D., Cravatt, B. F., Speers, A. E., et al. Target-based screen against a periplasmic serine protease that regulates intrabacterial pH homeostasis in Mycobacterium tuberculosis ACS Chemical Biology  2015 10:364-371  DOI:10.1021/cb500746z  PMID:25457457  PMCID:PMC4340348
    • Uematsu, M., Boger, D. L. Asymmetric synthesis of a CBI-based cyclic N-acyl O-amino phenol duocarmycin prodrug Journal of Organic Chemistry  2014 79:9699-9703  DOI:10.1021/jo501839x  PMID:25247380  PMCID:PMC4201355
    • Anderson, E. D., Duerfeldt, A. S., Zhu, K., Glinkerman, C. M., Boger, D. L. Cycloadditions of noncomplementary substituted 1,2,3-triazines Organic Letters  2014 16:5084-5087  DOI:10.1021/ol502436n  PMID:25222918  PMCID:PMC4184932
    • Okano, A., Nakayama, A., Schammel, A. W., Boger, D. L. Total synthesis of Psi C(=NH)NH Tpg(4) vancomycin and its ((4)-chlorobiphenyl)methyl derivative: impact of peripheral modifications on vancomycin analogues redesigned for dual D-Ala-D-Ala and D-Ala-D-Lac binding Journal of the American Chemical Society  2014 136:13522-13525  DOI:10.1021/ja507009a  PMID:25211770  PMCID:PMC4183650
    • Otrubova, K., Srinivasan, V., Boger, D. L. Discovery libraries targeting the major enzyme classes: the serine hydrolases Bioorganic & Medicinal Chemistry Letters  2014 24:3807-3813  DOI:10.1016/j.bmcl.2014.06.063  PMID:25037918  PMCID:PMC4130767
    • Sanchez-Cespedes, J., Moyer, C. L., Whitby, L. R., Boger, D. L., Nemerow, G. R. Inhibition of adenovirus replication by a trisubstituted piperazin-2-one derivative Antiviral Research  2014 108:65-73  DOI:10.1016/j.antiviral.2014.05.010  PMID:24907427  PMCID:PMC4101041
    • Nakayama, A., Okano, A., Feng, Y. Q., Collins, J. C., Collins, K. C., Walsh, C. T., Boger, D. L. Enzymatic glycosylation of vancomycin aglycon: completion of a total synthesis of vancomycin and N- and C-terminus substituent effects of the aglycon substrate Organic Letters  2014 16:3572-3575  DOI:10.1021/ol501568t  PMID:24954524  PMCID:PMC4084835
    • Duncan, K. K., Otrubova, K., Boger, D. L. alpha-Ketoheterocycle inhibitors of fatty acid amide hydrolase: exploration of conformational constraints in the acyl side chain Bioorganic & Medicinal Chemistry  2014 22:2763-2770  DOI:10.1016/j.bmc.2014.03.013  PMID:24690529  PMCID:PMC4029506
    • Lee, K., Boger, D. L. Total syntheses of (-)-kopsifoline D and (-)-deoxoapodine: divergent total synthesis via late-stage key strategic bond formation Journal of the American Chemical Society  2014 136:3312-3317  DOI:10.1021/ja500548e  PMID:24499015  PMCID:PMC3985950
    • Dreyton, C. J., Anderson, E. D., Subramanian, V., Boger, D. L., Thompson, P. R. Insights into the mechanism of streptonigrin-induced protein arginine deiminase inactivation Bioorganic & Medicinal Chemistry  2014 22:1362-1369  DOI:10.1016/j.bmc.2013.12.064  PMID:24440480  PMCID:PMC3954981
    • Otrubova, K., Cravatt, B. F., Boger, D. L. Design, synthesis, and characterization of alpha-ketoheterocycles that additionally target the cytosolic port Cys269 of fatty acid amide hydrolase Journal of Medicinal Chemistry  2014 57:1079-1089  DOI:10.1021/jm401820q  PMID:24456116  PMCID:PMC3940414
    • Duerfeldt, A. S., Boger, D. L. Total syntheses of (-)-pyrimidoblamic acid and P-3A Journal of the American Chemical Society  2014 136:2119-2125  DOI:10.1021/ja412298c  PMID:24410439  PMCID:PMC3940392
    • Campbell, E. L., Skepper, C. K., Sankar, K., Duncan, K. K., Boger, D. L. Transannular Diels-Alder/1,3-dipolar cycloaddition cascade of 1,3,4-oxadiazoles: total synthesis of a unique set of vinblastine analogues Organic Letters  2013 15:5306-5309  DOI:10.1021/oI402549n  PMID:24087969
    • Barker, T. J., Duncan, K. K., Otrubova, K., Boger, D. L. Potent vinblastine C20' ureas displaying additionally improved activity against a vinblastine-resistant cancer cell line ACS Medicinal Chemistry Letters  2013 4:985-988  DOI:10.1021/ml400281w  PMID:24223237  PMCID:PMC3821838
    • Wolfe, A. L., Duncan, K. K., Lajiness, J. P., Zhu, K. C., Duerfeldt, A. S., Boger, D. L. A fundamental relationship between hydrophobic properties and biological activity for the duocarmycin class of DNA-alkylating antitumor drugs: hydrophobic-binding-driven bonding Journal of Medicinal Chemistry  2013 56:6845-6857  DOI:10.1021/jm400665c  PMID:23944748  PMCID:PMC3793852
    • Pinchman, J. R., Boger, D. L. Investigation into the functional impact of the vancomycin C-ring aryl chloride Bioorganic & Medicinal Chemistry Letters  2013 23:4817-4819  DOI:10.1016/j.bmcl.2013.06.080  PMID:23880541  PMCID:PMC3757926
    • Connelly, S., DeMartino, J. K., Boger, D. L., Wilson, I. A. Biological and structural evaluation of 10R- and 10S-methylthio-DDACTHF reveals a new role for sulfur in inhibition of glycinamide ribonucleotide transformylase Biochemistry  2013 52:5133-5144  DOI:10.1021/bi4005182  PMID:23869564  PMCID:PMC3823235
    • Gochin, M., Whitby, L. R., Phillips, A. H., Boger, D. L. NMR-assisted computational studies of peptidomimetic inhibitors bound in the hydrophobic pocket of HIV-1 glycoprotein 41 Journal of Computer-Aided Molecular Design  2013 27:569-582  DOI:10.1007/s10822-013-9662-6  PMID:23893342  PMCID:PMC3777804
    • Vielhauer, G. A., Swink, M., Parelkar, N. K., Lajiness, J. P., Wolfe, A. L., Boger, D. Evaluation of a reductively activated duocarmycin prodrug against murine and human solid cancers Cancer Biology & Therapy  2013 14:527-536  DOI:10.4161/cbt.24348  PMID:23760495  PMCID:PMC3813569
    • Wolfe, A. L., Duncan, K. K., Parelkar, N. K., Brown, D., Vielhauer, G. A., Boger, D. L. Efficacious cyclic N-acyl O-amino phenol duocarmycin prodrugs Journal of Medicinal Chemistry  2013 56:4104-4115  DOI:10.1021/jm400413r  PMID:23627265  PMCID:PMC3687800
    • Pinchman, J. R., Boger, D. L. Probing the role of the vancomycin E-ring aryl chloride: selective divergent synthesis and evaluation of alternatively substituted E-ring analogues Journal of Medicinal Chemistry  2013 56:4116-4124  DOI:10.1021/jm4004494  PMID:23617725  PMCID:PMC3667592
    • Otrubova, K., Brown, M., McCormick, M. S., Han, G. W., O'Neal, S. T., Cravatt, B. F., Stevens, R. C., Lichtman, A. H., Boger, D. L. Rational design of fatty acid amide hydrolase inhibitors that act by covalently bonding to two active site residues Journal of the American Chemical Society  2013 135:6289-6299  DOI:10.1021/ja4014997  PMID:23581831  PMCID:PMC3678763
    • Turner, T. C., Shibayama, K., Boger, D. L. Hypervalent iodine(III)-promoted intermolecular C-C coupling of vindoline with β-ketoesters and related substrates Organic Letters  2013 15:1100-1103  DOI:10.1021/ol400135n  PMID:23421318  PMCID:PMC3607625
    • Xie, J., Wolfe, A. L., Boger, D. L. Total synthesis of kopsinine Organic Letters  2013 15:868-870  DOI:10.1021/ol303573f  PMID:23391149  PMCID:PMC3578506
    • Leggans, E. K., Duncan, K. K., Barker, T. J., Schleicher, K. D., Boger, D. L. A remarkable series of vinblastine analogues displaying enhanced activity and an unprecedented tubulin binding steric tolerance: C20' urea derivatives Journal of Medicinal Chemistry  2013 56:628-639  DOI:10.1021/jm3015684  PMID:23244701  PMCID:PMC3574233
    • Breazzano, S. P., Poudel, Y. B., Boger, D. L. A Pd(0)-mediated indole (macro)cyclization reaction Journal of the American Chemical Society  2013 135:1600-1606  DOI:10.1021/ja3121394  PMID:23298368  PMCID:PMC3560319
    • Schleicher, K. D., Sasaki, Y., Tam, A., Kato, D., Duncan, K. K., Boger, D. L. Total synthesis and evaluation of vinblastine analogues containing systematic deep-seated modifications in the vindoline subunit ring system: Core redesign Journal of Medicinal Chemistry  2013 56:483-495  DOI:10.1021/jm3014376  PMID:23252481  PMCID:PMC3554876
    • Whitby, L. R., Boger, D. L. Comprehensive peptidomimetic libraries targeting protein-protein interactions Accounts of Chemical Research  2012 45:1698-1709  DOI:10.1021/ar300025n  PMID:22799570  PMCID:PMC3473115
    • Barker, T. J., Boger, D. L. Fe(III)/NaBH4-mediated free radical hydrofluorination of unactivated alkenes Journal of the American Chemical Society  2012 134:13588-13591  DOI:10.1021/ja3063716  PMID:22860624  PMCID:PMC3425717
    • Gotoh, H., Sears, J. E., Eschenmoser, A., Boger, D. L. New insights into the mechanism and an expanded scope of the Fe(III)-mediated vinblastine coupling reaction Journal of the American Chemical Society  2012 134:13240-13243  DOI:10.1021/ja306229x  PMID:22856867  PMCID:PMC3430138
    • Wolfe, A. L., Duncan, K. K., Parelkar, N. K., Weir, S. J., Vielhauer, G. A., Boger, D. L. A novel, unusually efficacious duocarmycin carbamate prodrug that releases no residual byproduct Journal of Medicinal Chemistry  2012 55:5878-5886  DOI:10.1021/jm300330b  PMID:22650244  PMCID:PMC3386426
    • Okano, A., James, R. C., Pierce, J. G., Xie, J., Boger, D. L. Silver(I)-promoted conversion of thioamides to amidines: divergent synthesis of a key series of vancomycin aglycon residue 4 amidines that clarify binding behavior to model ligands Journal of the American Chemical Society  2012 134:8790-8793  DOI:10.1021/ja302808p  PMID:22568755  PMCID:PMC3365631
    • James, R. C., Pierce, J. G., Okano, A., Xie, J., Boger, D. L. Redesign of glycopeptide antibiotics: back to the future ACS Chemical Biology  2012 7:797-804  DOI:10.1021/cb300007j  PMID:22330049  PMCID:PMC3356478
    • Otrubova, K., Boger, D. L. α-Ketoheterocycle-based inhibitors of Fatty Acid Amide Hydrolase (FAAH) ACS Chemical Neuroscience  2012 3:340-348  DOI:10.1021/cn2001206  PMID:22639704  PMCID:PMC3359644
    • Lajiness, J. P., Jiang, W. L., Boger, D. L. Divergent total syntheses of (-)-aspidospermine and (+)-spegazzinine Organic Letters  2012 14:2078-2081  DOI:10.1021/ol300599p  PMID:22480368  PMCID:PMC3337885
    • Whitby, L. R., Boyle, K. E., Cai, L. F., Yu, X. Q., Gochin, M., Boger, D. L. Discovery of HIV fusion inhibitors targeting gp41 using a comprehensive α-helix mimetic library Bioorganic & Medicinal Chemistry Letters  2012 22:2861-2865  DOI:10.1016/j.bmcl.2012.02.062  PMID:22424973  PMCID:PMC3321071
    • Booker, L., Kinsey, S. G., Abdullah, R. A., Blankman, J. L., Long, J. Z., Ezzili, C., Boger, D. L., Cravatt, B. F., Lichtman, A. H. The fatty acid amide hydrolase (FAAH) inhibitor PF-3845 acts in the nervous system to reverse LPS-induced tactile allodynia in mice British Journal of Pharmacology  2012 165:2485-2496  DOI:10.1111/j.1476-5381.2011.01445.x  PMID:21506952  PMCID:PMC3423256
    • Leggans, E. K., Barker, T. J., Duncan, K. K., Boger, D. L. Iron(III)/NaBH4-mediated additions to unactivated alkenes: synthesis of novel 20'-vinblastine analogues Organic Letters  2012 14:1428-1431  DOI:10.1021/ol300173v  PMID:22369097  PMCID:PMC3306530
    • Xie, J., Okano, A., Pierce, J. G., James, R. C., Stamm, S., Crane, C. M., Boger, D. L. Total synthesis of [Psi[C(═S)NH]Tpg4]vancomycin aglycon, [Psi[C(═NH)NH]Tpg4]vancomycin aglycon, and related key compounds: reengineering vancomycin for dual D-Ala-D-Ala and D-Ala-D-Lac binding Journal of the American Chemical Society  2012 134:1284-1297  DOI:10.1021/ja209937s  PMID:22188323  PMCID:PMC3262083
    • Gotoh, H., Duncan, K. K., Robertson, W. M., Boger, D. L. 10 '-fluorovinblastine and 10 '-fluorovincristine: synthesis of a key series of modified vinca alkaloids ACS Medicinal Chemistry Letters  2011 2:948-952  DOI:10.1021/ml200236a  PMID:22247789  PMCID:PMC3254105
    • Breazzano, S. P., Boger, D. L. Synthesis and stereochemical determination of complestatin A and B (neuroprotectin A and B) Journal of the American Chemical Society  2011 133:18495-18502  DOI:10.1021/ja208570q  PMID:21991993  PMCID:PMC3217038
    • Xie, J., Pierce, J. G., James, R. C., Okano, A., Boger, D. L. A redesigned vancomycin engineered for dual D-Ala-D-ala And D-Ala-D-Lac binding exhibits potent antimicrobial activity against vancomycin-resistant bacteria Journal of the American Chemical Society  2011 133:13946-13949  DOI:10.1021/ja207142h  PMID:21823662  PMCID:PMC3164945
    • Boger, D. L. Tetrahedron Young Investigator Award 2011: Carolyn R. Bertozzi Bioorganic & Medicinal Chemistry Letters  2011 21:4944-4944  DOI:10.1016/j.bmcl.2011.08.013  PMID:21840475
    • Otrubova, K., Ezzili, C., Boger, D. L. The discovery and development of inhibitors of fatty acid amide hydrolase (FAAH) Bioorganic & Medicinal Chemistry Letters  2011 21:4674-4685  DOI:10.1016/j.bmcl.2011.06.096  PMID:21764305  PMCID:PMC3146581
    • Anderson, E. D., Boger, D. L. Inverse electron demand Diels-Alder reactions of 1,2,3-triazines: Pronounced substituent effects on reactivity and cycloaddition scope Journal of the American Chemical Society  2011 133:12285-12292  DOI:10.1021/ja204856a  PMID:21736324  PMCID:PMC3150293
    • Whitby, L. R., Ando, Y., Setola, V., Vogt, P. K., Roth, B. L., Boger, D. L. Design, synthesis, and validation of a β-turn mimetic library targeting protein-protein and peptide-receptor interactions Journal of the American Chemical Society  2011 133:10184-10194  DOI:10.1021/ja201878v  PMID:21609016  PMCID:PMC3134394
    • Anderson, E. D., Boger, D. L. Scope of the inverse electron demand Diels-Alder reactions of 1,2,3-triazine Organic Letters  2011 13:2492-2494  DOI:10.1021/ol2007428  PMID:21488676  PMCID:PMC3093666
    • Boger, D. L., Blagg, B. S. J., Johnson, D. S., Garbaccio, R. M. Recent advances in medicinal chemistry Bioorganic & Medicinal Chemistry Letters  2011 21:2585-2586  DOI:10.1016/j.bmcl.2011.04.019
    • Ezzili, C., Mileni, M., McGlinchey, N., Long, J. Z., Kinsey, S. G., Hochstatter, D. G., Stevens, R. C., Lichtman, A. H., Cravatt, B. F., Bilsky, E. J., Boger, D. L. Reversible competitive α-ketoheterocycle inhibitors of fatty acid amide hydrolase containing additional conformational constraints in the acyl side chain: orally active, long-acting analgesics Journal of Medicinal Chemistry  2011 54:2805-2822  DOI:10.1021/jm101597x  PMID:21428410  PMCID:PMC3085948
    • Mileni, M., Garfunkle, J., Ezzili, C., Cravatt, B. F., Stevens, R. C., Boger, D. L. Fluoride-mediated capture of a noncovalent bound state of a reversible covalent enzyme inhibitor: X-ray crystallographic analysis of an exceptionally potent α-ketoheterocycle inhibitor of fatty acid amide hydrolase Journal of the American Chemical Society  2011 133:4092-4100  DOI:10.1021/ja110877y  PMID:21355555  PMCID:PMC3060301
    • Thomas, C. J., Casquilho-Gray, H. E., York, J., DeCamp, D. L., Dai, D. C., Petrilli, E. B., Boger, D. L., Slayden, R. A., Amberg, S. M., Sprang, S. R., Nunberg, J. H. A specific interaction of small molecule entry inhibitors with the envelope glycoprotein complex of the Junin hemorrhagic fever arenavirus Journal of Biological Chemistry  2011 286:6192-6200  DOI:10.1074/jbc.M110.196428  PMID:21159779  PMCID:PMC3057843
    • Lajiness, J. P., Boger, D. L. Asymmetric synthesis of 1,2,9,9a-tetrahydrocyclopropa[c]benzo[e]indol-4-one (CBI) Journal of Organic Chemistry  2011 76:583-587  DOI:10.1021/jo102136w  PMID:21192653  PMCID:PMC3079324
    • Burke, C. P., Swingle, M. R., Honkanen, R. E., Boger, D. L. Total synthesis and evaluation of phostriecin and key structural analogues Journal of Organic Chemistry  2010 75:7505-7513  DOI:10.1021/jo1010203  PMID:20669916  PMCID:PMC2978778
    • Tam, A., Gotoh, H., Robertson, W. M., Boger, D. L. Catharanthine C16 substituent effects on the biomimetic coupling with vindoline: preparation and evaluation of a key series of vinblastine analogues Bioorganic & Medicinal Chemistry Letters  2010 20:6408-6410  DOI:10.1016/j.bmcl.2010.09.091  PMID:20932748  PMCID:PMC2957881
    • Lajiness, J. P., Robertson, W. M., Dunwiddie, I., Broward, M. A., Vielhauer, G. A., Weir, S. J., Boger, D. L. Design, synthesis, and evaluation of duocarmycin O-amino phenol prodrugs subject to tunable reductive activation Journal of Medicinal Chemistry  2010 53:7731-7738  DOI:10.1021/jm1010397  PMID:20942408  PMCID:PMC2974002
    • Ambrus, G., Whitby, L. R., Singer, E. L., Trott, O., Choi, E., Olson, A. J., Boger, D. L., Gerace, L. Small molecule peptidomimetic inhibitors of importin α/β mediated nuclear transport Bioorganic & Medicinal Chemistry  2010 18:7611-7620  DOI:10.1016/j.bmc.2010.08.038  PMID:20869252  PMCID:PMC2966498
    • Ezzili, C., Otrubova, K., Boger, D. L. Fatty acid amide signaling molecules Bioorganic & Medicinal Chemistry Letters  2010 20:5959-5968  DOI:10.1016/j.bmcl.2010.08.048  PMID:20817522  PMCID:PMC2942981
    • Crane, C. M., Pierce, J. G., Leung, S. S. F., Tirado-Rives, J., Jorgensen, W. L., Boger, D. L. Synthesis and evaluation of selected key methyl ether derivatives of vancomycin aglycon Journal of Medicinal Chemistry  2010 53:7229-7235  DOI:10.1021/jm100946e  PMID:20853900  PMCID:PMC2981068
    • Lajiness, J. P., Boger, D. L. Synthesis and characterization of a cyclobutane duocarmycin derivative incorporating the 1,2,10,11-tetrahydro-9H-cyclobuta[c]benzo[e]indol-4-one (CbBI) alkylation subunit Journal of the American Chemical Society  2010 132:13936-13940  DOI:10.1021/ja106986f  PMID:20839806  PMCID:PMC2952436
    • Sasaki, Y., Kato, D., Boger, D. L. Asymmetric total synthesis of vindorosine, vindoline, and key vinblastine analogues Journal of the American Chemical Society  2010 132:13533-13544  DOI:10.1021/ja106284s  PMID:20809620  PMCID:PMC2944909
    • Patel, P. R., Boger, D. L. Intramolecular Diels-Alder reactions of cyclopropenone ketals Organic Letters  2010 12:3540-3543  DOI:10.1021/ol101375a  PMID:20614867  PMCID:PMC2912946
    • Chang, M. W., Giffin, M. J., Muller, R., Savage, J., Lin, Y. C., Hong, S., Jin, W., Whitby, L. R., Elder, J. H., Boger, D. L., Torbett, B. E. Identification of broad-based HIV-1 protease inhibitors from combinatorial libraries Biochemical Journal  2010 429:527-532  DOI:10.1042/bj20091645  PMID:20507280  PMCID:PMC3084599
    • Patel, P. R., Boger, D. L. Intramolecular 1+2 and 3+2 cycloaddition reactions of cyclopropenone ketals Journal of the American Chemical Society  2010 132:8527-8529  DOI:10.1021/ja103933n  PMID:20527885  PMCID:PMC2892887
    • Va, P., Campbell, E. L., Robertson, W. M., Boger, D. L. Total synthesis and evaluation of a key series of C5-substituted vinblastine derivatives Journal of the American Chemical Society  2010 132:8489-8495  DOI:10.1021/ja1027748  PMID:20518465  PMCID:PMC2903230
    • Shimamura, H., Breazzano, S. P., Garfunkle, J., Kimball, F. S., Trzupek, J. D., Boger, D. L. Total synthesis of complestatin: development of a Pd(0)-mediated indole annulation for macrocyclization Journal of the American Chemical Society  2010 132:7776-7783  DOI:10.1021/ja102304p  PMID:20469945  PMCID:PMC2892899
    • Robertson, W. M., Kastrinsky, D. B., Hwang, I., Boger, D. L. Synthesis and evaluation of a series of C5'-substituted duocarmycin SA analogs Bioorganic & Medicinal Chemistry Letters  2010 20:2722-2725  DOI:10.1016/j.bmcl.2010.03.078  PMID:20381346  PMCID:PMC2867475
    • Boyle, K. E., MacMillan, K. S., Ellis, D. A., Lajiness, J. P., Robertson, W. M., Boger, D. L. Synthesis and evaluation of duocarmycin SA analogs incorporating the methyl 1,2,8,8a-tetrahydrocyclopropa[c]oxazolo[2,3-e]indol-4-one-6-carboxylate (COI) alkylation subunit Bioorganic & Medicinal Chemistry Letters  2010 20:1854-1857  DOI:10.1016/j.bmcl.2010.01.145  PMID:20171886  PMCID:PMC2965170
    • Campbell, E. L., Zuhl, A. M., Liu, C. M., Boger, D. L. Total synthesis of (+)-fendleridine (aspidoalbidine) and (+)-1-acetylaspidoalbidine Journal of the American Chemical Society  2010 132:3009-3012  DOI:10.1021/ja908819q  PMID:20148585  PMCID:PMC2832086
    • Oakdale, J. S., Boger, D. L. Total synthesis of lycogarubin C and lycogalic acid Organic Letters  2010 12:1132-1134  DOI:10.1021/ol100146b  PMID:20148525  PMCID:PMC2832087
    • Burke, C. P., Haq, N., Boger, D. L. Total synthesis, assignment of the relative and absolute stereochemistry, and structural reassignment of phostriecin (aka Sultriecin) Journal of the American Chemical Society  2010 132:2157-2159  DOI:10.1021/ja9097252  PMID:20108904  PMCID:PMC2824046
    • Mileni, M., Garfunkle, J., Ezzili, C., Kimball, F. S., Cravatt, B. F., Stevens, R. C., Boger, D. L. X-ray crystallographic analysis of alpha-ketoheterocycle inhibitors bound to a humanized variant of fatty acid amide hydrolase Journal of Medicinal Chemistry  2010 53:230-240  DOI:10.1021/jm9012196  PMID:19924997  PMCID:PMC2804032
    • Kato, D., Sasaki, Y., Boger, D. L. Asymmetric total synthesis of vindoline Journal of the American Chemical Society  2010 132:3685-3687  DOI:10.1021/ja910695e  PMID:20187641  PMCID:PMC2854892
    • Subramanian, V., Williams, R. M., Boger, D. L., Luger, K. Methods to characterize the effect of DNA-modifying compounds on nucleosomal DNA Methods in Molecular Biology  2010 613:173-192  DOI:10.1007/978-1-60327-418-0_11  PMID:19997884
    • MacMillan, K. S., Lajiness, J. P., Cara, C. L., Romagnoli, R., Robertson, W. M., Hwang, I., Baraldi, P. G., Boger, D. L. Synthesis and evaluation of a thio analogue of duocarmycin SA Bioorganic & Medicinal Chemistry Letters  2009 19:6962-6965  DOI:10.1016/j.bmcl.2009.10.063  PMID:19879753  PMCID:PMC2784222
    • Garfunkle, J., Kimball, F. S., Trzupek, J. D., Takizawa, S., Shimamura, H., Tomishima, M., Boger, D. L. Total synthesis of chloropeptin II (complestatin) and chloropeptin I Journal of the American Chemical Society  2009 131:16036-16038  DOI:10.1021/ja907193b  PMID:19839632  PMCID:PMC2783344
    • Fang, X., Nam, J., Shin, D., Rew, Y., Boger, D. L., Walker, S. Functional and biochemical analysis of a key series of ramoplanin analogues Bioorganic & Medicinal Chemistry Letters  2009 19:6189-6191  DOI:10.1016/j.bmcl.2009.09.001  PMID:19783144  PMCID:PMC2767165
    • Shi, J., Stover, J. S., Whitby, L. R., Vogt, P. K., Boger, D. L. Small molecule inhibitors of Myc/Max dimerization and Myc-induced cell transformation Bioorganic & Medicinal Chemistry Letters  2009 19:6038-6041  DOI:10.1016/j.bmcl.2009.09.044  PMID:19800226  PMCID:PMC2767179
    • MacMillan, K. S., Boger, D. L. Fundamental relationships between structure, reactivity, and biological activity for the duocarmycins and CC-1065 Journal of Medicinal Chemistry  2009 52:5771-5780  DOI:10.1021/jm9006214  PMID:19639994  PMCID:PMC2755654
    • Swingle, M. R., Amable, L., Lawhorn, B. G., Buck, S. B., Burke, C. P., Ratti, P., Fischer, K. L., Boger, D. L., Honkanen, R. E. Structure-activity relationship studies of fostriecin, cytostatin, and key analogs, with PP1, PP2A, PP5, and( beta12-beta13)-chimeras (PP1/PP2A and PP5/PP2A), provide further insight into the inhibitory actions of fostriecin family inhibitors Journal of Pharmacology and Experimental Therapeutics  2009 331:45-53  DOI:10.1124/jpet.109.155630  PMID:19592665  PMCID:PMC2766224
    • Kinsey, S. G., Long, J. Z., O'Neal, S. T., Abdullah, R. A., Poklis, J. L., Boger, D. L., Cravatt, B. F., Lichtman, A. H. Blockade of endocannabinoid-degrading enzymes attenuates neuropathic pain Journal of Pharmacology and Experimental Therapeutics  2009 330:902-910  DOI:10.1124/jpet.109.155465  PMID:19502530  PMCID:PMC2729802
    • Gauss, C. M., Hamasaki, A., Parrish, J. P., MacMillan, K. S., Rayl, T. J., Hwang, I., Boger, D. L. Synthesis and preliminary evaluation of duocarmycin analogues incorporating the 1,2,11,11a-tetrahydrocyclopropa c naphtho 2,3-e indol-4-one (CNI) and 1,2,11,11a-tetrahydrocyclopropa c naphtho 1,2-e indol-4-one (iso-CNI) alkylation subunits Tetrahedron  2009 65:6591-6599  DOI:10.1016/j.tet.2009.02.065  PMID:20161204  PMCID:PMC2713043
    • Mileni, M., Garfunkle, J., DeMartino, J. K., Cravatt, B. F., Boger, D. L., Stevens, R. C. Binding and inactivation mechanism of a humanized fatty acid amide hydrolase by alpha-ketoheterocycle inhibitors revealed from cocrystal structures Journal of the American Chemical Society  2009 131:10497-10506  DOI:10.1021/ja902694n  PMID:19722626  PMCID:PMC2739126
    • Hauschild, K. E., Stover, J. S., Boger, D. L., Ansari, A. Z. CSI-FID: high throughput label-free detection of DNA binding molecules Bioorganic & Medicinal Chemistry Letters  2009 19:3779-3782  DOI:10.1016/j.bmcl.2009.04.097  PMID:19435662  PMCID:PMC2760306
    • Whitby, L. R., Lee, A. M., Kunz, S., Oldstone, M. B. A., Boger, D. L. Characterization of lassa virus cell entry inhibitors: Determination of the active enantiomer by asymmetric synthesis Bioorganic & Medicinal Chemistry Letters  2009 19:3771-3774  DOI:10.1016/j.bmcl.2009.04.098  PMID:19428249  PMCID:PMC2742202
    • Clark, R. C., Lee, S. Y., Hwang, I., Searcey, M., Boger, D. L. Evaluation of chlorofusin, its seven chromophore diastereomers, and key analogues Tetrahedron Letters  2009 50:3151-3153  DOI:10.1016/j.tetlet.2009.01.081  PMID:20161293  PMCID:PMC2697908
    • Shaginian, A., Whitby, L. R., Hong, S., Hwang, I., Farooqi, B., Searcey, M., Chen, J. C., Vogt, P. K., Boger, D. L. Design, synthesis, and evaluation of an α-helix mimetic library targeting protein-protein interactions Journal of the American Chemical Society  2009 131:5564-5572  DOI:10.1021/ja810025g  PMID:19334711  PMCID:PMC2765553
    • Lee, S. Y., Boger, D. L. Synthesis of the chlorofusin cyclic peptide Tetrahedron  2009 65:3281-3284  DOI:10.1016/j.tet.2008.09.029  PMID:20047009  PMCID:PMC2665043
    • Ishikawa, H., Colby, D. A., Seto, S., Va, P., Tam, A., Kakei, H., Rayl, T. J., Hwang, I., Boger, D. L. Total synthesis of vinblastine, vincristine, related natural products, and key structural analogues Journal of the American Chemical Society  2009 131:4904-4916  DOI:10.1021/ja809842b  PMID:19292450  PMCID:PMC2727944
    • Schlosburg, J. E., Boger, D. L., Cravatt, B. F., Lichtman, A. H. Endocannabinoid modulation of scratching response in an acute allergenic model: a new prospective neural therapeutic target for pruritus Journal of Pharmacology and Experimental Therapeutics  2009 329:314-323  DOI:10.1124/jpet.108.150136  PMID:19168707  PMCID:PMC2670585
    • Crane, C. M., Boger, D. L. Synthesis and evaluation of vancomycin aglycon analogues that bear modifications in the N-terminal D-leucyl amino acid Journal of Medicinal Chemistry  2009 52:1471-1476  DOI:10.1021/jm801549b  PMID:19209892  PMCID:PMC2765482
    • Stover, J. S., Shi, J., Jin, W., Vogt, P. K., Boger, D. L. Discovery of inhibitors of aberrant gene transcription from libraries of DNA binding molecules: Inhibition of LEF-1-mediated gene transcription and oncogenic transformation Journal of the American Chemical Society  2009 131:3342-3348  DOI:10.1021/ja809083d  PMID:19216569  PMCID:PMC2787879
    • Ishikawa, H., Boger, D. L. Total synthesis of vindoline and related alkaloids Journal of Synthetic Organic Chemistry Japan  2009 67:123-133  DOI:10.5059/yukigoseikyokaishi.67.123
    • MacMillan, K. S., Nguyen, T., Hwang, I., Boger, D. L. Total synthesis and evaluation of iso-duocarmycin SA and iso-yatakemycin Journal of the American Chemical Society  2009 131:1187-1194  DOI:10.1021/ja808108q  PMID:19154178  PMCID:PMC2646182
    • Clark, R. C., Lee, S. Y., Searcey, M., Boger, D. L. The isolation, total synthesis and structure elucidation of chlorofusin, a natural product inhibitor of the p53-mDM2 protein-protein interaction Natural Product Reports  2009 26:465-477  DOI:10.1039/b821676b  PMID:19642417  PMCID:PMC2719831
    • MacMillan, K. S., Boger, D. L. An additional spirocyclization for duocarmycin SA Journal of the American Chemical Society  2008 130:16521-16523  DOI:10.1021/ja806593w  PMID:19554689  PMCID:PMC2891557
    • Slaymaker, I. M., Bracey, M., Mileni, M., Garfunkle, J., Cravatt, B. F., Boger, D. L., Stevens, R. C. Correlation of inhibitor effects on enzyme activity and thermal stability for the integral membrane protein fatty acid amide hydrolase Bioorganic & Medicinal Chemistry Letters  2008 18:5847-5850  DOI:10.1016/j.bmcl.2008.06.086  PMID:18644727  PMCID:PMC2794692
    • DeMartino, J. K., Garfunkle, J., Hochstatter, D. G., Cravatt, B. F., Boger, D. L. Exploration of a fundamental substituent effect of α-ketoheterocycle enzyme inhibitors: Potent and selective inhibitors of fatty acid amide hydrolase Bioorganic & Medicinal Chemistry Letters  2008 18:5842-5846  DOI:10.1016/j.bmcl.2008.06.084  PMID:18639454  PMCID:PMC2582052
    • DeMartino, J. K., Boger, D. L. Glycinamide ribonucleotide transformylase (GAR Tfase) as a target for cancer therapy Drugs of the Future  2008 33:969-979  DOI:10.1358/dof.2008.33.11.1247542
    • Clark, R. C., Lee, S. Y., Boger, D. L. Total synthesis of chlorofusin, its seven chromophore diastereomers, and key partial structures Journal of the American Chemical Society  2008 130:12355-12369  DOI:10.1021/ja8012819  PMID:18712872  PMCID:PMC2587114
    • DeMartino, J. K., Hwang, I., Connelly, S., Wilson, I. A., Boger, D. L. Asymmetric synthesis of inhibitors of glycinamide ribonucleotide transformylase Journal of Medicinal Chemistry  2008 51:5441-5448  DOI:10.1021/jm800555h  PMID:18686942  PMCID:PMC2559975
    • Garfunkle, J., Ezzili, C., Rayl, T. J., Hochstatter, D. G., Hwang, I., Boger, D. L. Optimization of the central heterocycle of alpha-ketoheterocycle inhibitors of fatty acid amide hydrolase Journal of Medicinal Chemistry  2008 51:4392-4403  DOI:10.1021/jm800136b  PMID:18630870  PMCID:PMC2556205
    • Lee, A. M., Rojek, J. M., Spiropoulou, C. F., Gundersen, A. T., Jin, W., Shaginian, A., York, J., Nunberg, J. H., Boger, D. L., Oldstone, M. B. A., Kunz, S. Unique small molecule entry inhibitors of hemorrhagic fever arenaviruses Journal of Biological Chemistry  2008 283:18734-18742  DOI:10.1074/jbc.M802089200  PMID:18474596  PMCID:PMC2441566
    • Di Micco, S., Boger, D. L., Riccio, R., Bifulco, G. Structural features of the (+)-Yatakemycin/d(GACTAATTGAC)-(GTCAATTAGTC) complex: Quantum mechanical calculation of NMR parameters as a tool for the characterization of ligand/DNA Interactions European Journal of Organic Chemistry  2008 2454-2462  DOI:10.1002/ejoc.200701212
    • Lu, X. H., Vogt, P. K., Boger, D. L., Lunec, J. Disruption of the MYC transcriptional function by a small-molecule antagonist of MYC/MAX dimerization Oncology Reports  2008 19:825-830  PMID:18288422
    • Kimball, F. S., Romero, F. A., Ezzili, C., Garfunkle, J., Rayl, T. J., Hochstatter, D. G., Hwang, I., Boger, D. L. Optimization of alpha-ketooxazole inhibitors of fatty acid amide hydrolase Journal of Medicinal Chemistry  2008 51:937-947  DOI:10.1021/jm701210y  PMID:18247553  PMCID:PMC2734917
    • Ishikawa, H., Colby, D. A., Boger, D. L. Direct coupling of catharanthine and vindoline to provide vinblastine: Total synthesis of (+)- and ent-(-)-vinblastine Journal of the American Chemical Society  2008 130:420-421  DOI:10.1021/ja078192m  PMID:18081297  PMCID:PMC2570212
    • Tichenor, M. S., Boger, D. L. Yatakemycin: Total synthesis, DNA alkylation, and biological properties Natural Product Reports  2008 25:220-226  DOI:10.1039/b705665f  PMID:18389136
    • Jin, W., Trzupek, J. D., Rayl, T. J., Broward, M. A., Vielhauer, G. A., Weir, S. J., Hwang, I., Boger, D. L. A unique class of duocarmycin and CC-1065 analogues subject to reductive activation Journal of the American Chemical Society  2007 129:15391-15397  DOI:10.1021/ja075398e  PMID:18020335  PMCID:PMC2519901
    • Tichenor, M. S., MacMillan, K. S., Stover, J. S., Wolkenberg, S. E., Pavani, M. G., Zanella, L., Zaid, A. N., Spalluto, G., Rayl, T. J., Hwang, I., Baraldi, P. G., Boger, D. L. Rational design, synthesis, and evaluation of key analogues of CC-1065 and the duocarmycins Journal of the American Chemical Society  2007 129:14092-14099  DOI:10.1021/ja073989z  PMID:17948994  PMCID:PMC2531197
    • Tichenor, M. S., MacMillan, K. S., Trzupek, J. D., Rayl, T. J., Hwang, I., Boger, D. L. Systematic exploration of the structural features of yatakemycin impacting DNA alkylation and biological activity Journal of the American Chemical Society  2007 129:10858-10869  DOI:10.1021/ja072777z  PMID:17691783  PMCID:PMC2519902
    • Lee, S. Y., Clark, R. C., Boger, D. L. Total synthesis, stereochemical reassignment, and absolute configuration of chlorofusin Journal of the American Chemical Society  2007 129:9860-9861  DOI:10.1021/ja073264v  PMID:17637057  PMCID:PMC2531192
    • Nam, J., Shin, D., Rew, Y., Boger, D. L. Alanine scan of [L-Dap2]ramoplanin A2 aglycon:  Assessment of the importance of each residue Journal of the American Chemical Society  2007 129:8747-8755  DOI:10.1021/ja068573k  PMID:17592838  PMCID:PMC2593884
    • Hardouin, C., Kelso, M. J., Romero, F. A., Rayl, T. J., Leung, D., Hwang, I., Cravatt, B. F., Boger, D. L. Structure-activity relationships of alpha-ketooxazole inhibitors of fatty acid amide hydrolase Journal of Medicinal Chemistry  2007 50:3359-3368  DOI:10.1021/jm061414r  PMID:17559203  PMCID:PMC2531194
    • Xu, L., Chong, Y. H., Hwang, I. Y., D'Onofrio, A., Amore, K., Beardsley, G. P., Li, C. L., Olson, A. J., Boger, D. L., Wilson, I. A. Structure-based design, synthesis, evaluation, and crystal structures of transition state analogue inhibitors of inosine monophosphate cyclohydrolase Journal of Biological Chemistry  2007 282:13033-13046  DOI:10.1074/jbc.M607293200  PMID:17324932
    • Ishikawa, H., Boger, D. L. Total synthesis of (-)- and ent-(+)-4-desacetoxy-5-desethylvindoline Heterocycles  2007 72:95-102  DOI:10.3987/COM-06-S(K)8
    • Romero, F. A., Du, W., Hwang, I., Rayl, T. J., Kimball, F. S., Leung, D., Hoover, H. S., Apodaca, R. L., Breitenbucher, J. G., Cravatt, B. F., Boger, D. L. Potent and selective alpha-ketoheterocycle-based inhibitors of the anandamide and oleamide catabolizing enzyme, fatty acid amide hydrolase Journal of Medicinal Chemistry  2007 50:1058-1068  DOI:10.1021/jm0611509  PMID:17279740  PMCID:PMC2531193
    • Dickerson, T. J., Clancy, C. M., Johnson, E. A., Baldwin, M. R., Jin, W., Barbieri, J. T., Tepp, W. H., Eubanks, L. M., Malizio, C. J., Goodnough, M. C., Janda, K. D., Hong, S., et al. An in vitro and in vivo disconnect uncovered through high-throughput identification of botulinum neurotoxin A antagonists Proceedings of the National Academy of Sciences of the United States of America  2007 104:2602-2607  DOI:10.1073/pnas.0611213104  PMID:17293454  PMCID:PMC1815229
    • Lawhorn, B. G., Boga, S. B., Wolkenberg, S. E., Boger, D. L. Total synthesis of cytostatin Heterocycles  2006 70:65-70  DOI:10.3987/COM-06-S(W)13
    • Lawhorn, B. G., Boga, S. B., Wolkenberg, S. E., Colby, D. A., Gauss, C. M., Swingle, M. R., Amable, L., Honkanen, R. E., Boger, D. L. Total synthesis and evaluation of cytostatin, its C10-C11 diastereomers, and additional key analogues: Impact on PP2A inhibition Journal of the American Chemical Society  2006 128:16720-16732  DOI:10.1021/ja066477d  PMID:17177422  PMCID:PMC2566737
    • Tichenor, M. S., Trzupek, J. D., Kastrinsky, D. B., Shiga, F., Hwang, I., Boger, D. L. Asymmetric total synthesis of (+)- and ent-(-)-yatakemycin and duocarmycin SA: evaluation of yatakemycin key partial structures and its unnatural enantiomer Journal of the American Chemical Society  2006 128:15683-15696  DOI:10.1021/ja064228j  PMID:17147378  PMCID:PMC2515590
    • Romero, F. A., Hwang, I., Boger, D. L. Delineation of a fundamental alpha-ketoheterocycle substituent effect for use in the design of enzyme inhibitors Journal of the American Chemical Society  2006 128:14004-14005  DOI:10.1021/ja064522b  PMID:17061864  PMCID:PMC2501112
    • Schnermann, M. J., Romero, F. A., Hwang, I., Nakamaru-Ogiso, E., Yagi, T., Boger, D. L. Total synthesis of piericidin A1 and B1 and key analogues Journal of the American Chemical Society  2006 128:11799-11807  DOI:10.1021/ja0632862  PMID:16953619  PMCID:PMC2531196
    • Elliott, G. I., Fuchs, J. R., Blagg, B. S. J., Ishikawa, H., Tao, H. C., Yuan, Z. Q., Boger, D. L. Intramolecular Diels-Alder/1,3-dipolar cycloaddition cascade of 1,3,4-oxadiazoles Journal of the American Chemical Society  2006 128:10589-10595  DOI:10.1021/ja0612549  PMID:16895427  PMCID:PMC2587417
    • Ishikawa, H., Elliott, G. I., Velcicky, J., Choi, Y., Boger, D. L. Total synthesis of (-)- and ent-(+)-vindoline and related alkaloids Journal of the American Chemical Society  2006 128:10596-10612  DOI:10.1021/ja061256t  PMID:16895428  PMCID:PMC2531198
    • DeMartino, J. K., Hwang, I., Xu, L., Wilson, I. A., Boger, D. L. Discovery of a potent, nonpolyglutamatable inhibitor of glycinamide ribonucleotide transformylase Journal of Medicinal Chemistry  2006 49:2998-3002  DOI:10.1021/jm0601147  PMID:16686541  PMCID:PMC2531195
    • Crowley, B. M., Boger, D. L. Total synthesis and evaluation of [Ψ[CH(2)NH]Tpg(4)]vancomycin aglycon: reengineering vancomycin for dual D-Ala-D-Ala and D-Ala-D-Lac binding Journal of the American Chemical Society  2006 128:2885-2892  DOI:10.1021/ja0572912  PMID:16506767  PMCID:PMC2586002
    • Clark, R. C., Pfeiffer, S. S., Boger, D. L. Diastereoselective Diels-Alder reactions of N-sulfonyl-1-aza-1,3-butadienes with optically active enol ethers: An asymmetric variant of the 1-azadiene Diels-Alder reaction Journal of the American Chemical Society  2006 128:2587-2593  DOI:10.1021/ja0571646  PMID:16492042  PMCID:PMC2525448
    • Trzupek, J. D., Gottesfeld, J. M., Boger, D. L. Alkylation of duplex DNA in nucleosome core particles by duocarmycin SA and yatakemycin Nature Chemical Biology  2006 2:79-82  DOI:10.1038/nchembio761  PMID:16415862
    • Hamasaki, A., Ducray, R., Boger, D. L. Two novel 1,2,4,5-tetrazines that participate in inverse electron demand Diels-Alder reactions with an unexpected regioselectivity Journal of Organic Chemistry  2006 71:185-193  DOI:10.1021/jo051832o  PMID:16388634  PMCID:PMC2525609
    • Fang, X., Tiyanont, K., Zhang, Y., Wanner, J., Boger, D., Walker, S. The mechanism of action of ramoplanin and enduracidin Molecular Biosystems  2006 2:69-76  DOI:10.1039/b515328j  PMID:16880924
    • Elliott, G. I., Velcicky, J., Ishikawa, H., Li, Y. K., Boger, D. L. Total synthesis of (-)- and ent-(+)-vindorosine: Tandem intramolecular Diels-Alder/1,3-dipolar cycloaddition of 1,3,4-oxadiazoles Angewandte Chemie-International Edition  2006 45:620-622  DOI:10.1002/anie.200503024  PMID:16355429
    • Guimaraes, C. R. W., Boger, D. L., Jorgensen, W. L. Elucidation of fatty acid amide hydrolase inhibition by potent alpha-ketoheterocycle derivatives from Monte Carlo simulations Journal of the American Chemical Society  2005 127:17377-17384  DOI:10.1021/ja055438j  PMID:16332087
    • Schnermann, M. J., Boger, D. L. Total synthesis of piericidin A1 and B1 Journal of the American Chemical Society  2005 127:15704-15705  DOI:10.1021/ja055041f  PMID:16277503  PMCID:PMC2504520
    • Chou, T. C., Guan, Y. B., Soenen, D. R., Danishefsky, S. J., Boger, D. L. Potent reversal of multidrug resistance by ningalins and its use in drug combinations against human colon carcinoma xenograft in nude mice Cancer Chemotherapy and Pharmacology  2005 56:379-390  DOI:10.1007/s00280-005-1019-y  PMID:15875185
    • Choi, Y. G., Ishikawa, H., Velcicky, J., Elliott, G. I., Miller, M. M., Boger, D. L. Total synthesis of (-)- and ent-(+)-vindoline Organic Letters  2005 7:4539-4542  DOI:10.1021/o1051975x  PMID:16178578
    • Boger, D. L. Bioorganic & Medicinal Chemistry Letters Symposia-in-Print Bioorganic & Medicinal Chemistry Letters  2005 15:3652-3652  DOI:10.1016/j.bmcl.2005.07.002
    • Hamasaki, A., Zimpleman, J. M., Hwang, I., Boger, D. L. Total synthesis of ningalin D Journal of the American Chemical Society  2005 127:10767-10770  DOI:10.1021/ja0526416  PMID:16045367  PMCID:PMC2480523
    • Capps, K. J., Humiston, J., Dominique, R., Hwang, I., Boger, D. L. Discovery of aicar tfase inhibitors that disrupt requisite enzyme dimerization Bioorganic & Medicinal Chemistry Letters  2005 15:2840-2844  DOI:10.1016/j.bcml.2005.03.094  PMID:15911265
    • Cheng, H., Chong, Y. H., Hwang, I., Tavassoli, A., Zhang, Y., Wilson, I. A., Benkovic, S. J., Boger, D. L. Design, synthesis, and biological evaluation of 10-methanesulfonyl-DDACTHF, 10-methanesulfonyl-5-DACTHF, and 10-methylthio-DDACTHF as potent inhibitors of GAR Tfase and the de novo purine biosynthetic pathway Bioorganic & Medicinal Chemistry  2005 13:3577-3585  DOI:10.1016/j.bmc.2004.12.004  PMID:15848770
    • Cheng, H., Hwang, I., Chong, Y. H., Tavassoli, A., Webb, M. E., Zhang, Y., Wilson, I. A., Benkovic, S. J., Boger, D. L. Synthesis and biological evaluation of N-{4- 5-(2,4-diamino-6-oxo-1,6-dihydropyrimidin-5-yl)-2-(2,2,2-trifluoro acetyl)pentyl)benzoyl}-L-glutamic acid as a potential inhibitor of GAR Tfase and the de novo purine biosynthetic pathway Bioorganic & Medicinal Chemistry  2005 13:3593-3599  DOI:10.1016/j.bme.2004.11.049  PMID:15848772
    • Chong, Y., Hwang, I., Tavassoli, A., Zhang, Y., Wilson, I. A., Benkovic, S. J., Boger, D. L. Synthesis and biological evaluation of α- and γ-carboxamide derivatives of 10-CF3CO-DDACTHF Bioorganic & Medicinal Chemistry  2005 13:3587-3592  DOI:10.1016/j.bme.2004.11.050  PMID:15848771
    • Boger, D. L., Miyauchi, H., Du, W., Hardouin, C., Fecik, R. A., Cheng, H., Hwang, I., Hedrick, M. P., Leung, D., Acevedo, O., Guimaraes, C. R. W., Jorgensen, W. L., et al. Discovery of a potent, selective, and efficacious class of reversible alpha-ketoheterocycle inhibitors of fatty acid amide hydrolase effective as analgesics Journal of Medicinal Chemistry  2005 48:1849-1856  DOI:10.1021/jm049614v  PMID:15771430  PMCID:PMC2492884
    • Leung, D., Du, W., Hardouin, C., Cheng, H., Hwang, I., Cravatt, B. F., Boger, D. L. Discovery of an exceptionally potent and selective class of fatty acid amide hydrolase inhibitors enlisting proteome-wide selectivity screening: concurrent optimization of enzyme inhibitor potency and selectivity Bioorganic & Medicinal Chemistry Letters  2005 15:1423-1428  DOI:10.1016/j.bmcl.2004.12.085  PMID:15713400
    • Walker, S., Chen, L., Hu, Y. N., Rew, Y., Shin, D. W., Boger, D. L. Chemistry and biology of ramoplanin: A lipoglycodepsipeptide with potent antibiotic activity Chemical Reviews  2005 105:449-475  DOI:10.1021/cr030106n  PMID:15700952
    • Du, W., Hardouin, C., Cheng, H., Hwang, I., Boger, D. L. Heterocyclic sulfoxide and sulfone inhibitors of fatty acid amide hydrolase Bioorganic & Medicinal Chemistry Letters  2005 15:103-106  DOI:10.1016/j.bmcl.2004.10.025  PMID:15582420
    • Yuan, Z. Q., Ishikawa, H., Boger, D. L. Total synthesis of natural (-)- and ent-(+)-4-desacetoxy-6,7-dihydrovindorosine and natural and ent-minovine: Oxadiazole tandem intramolecular Diels-Alder/1,3-dipolar cycloaddition reaction Organic Letters  2005 7:741-744  DOI:10.1021/ol050017s  PMID:15704939  PMCID:PMC2587128
    • Tao, H. C., Hwang, I. K., Boger, D. L. Multidrug resistance reversal activity of permethyl ningalin B amide derivatives Bioorganic & Medicinal Chemistry Letters  2004 14:5979-5981  DOI:10.1016/j.bmcl.2004.10.002  PMID:15546712
    • Tse, W. C., Boger, D. L. Sequence-selective DNA recognition: natural products and nature's lessons Chemistry & Biology  2004 11:1607-1617  DOI:10.1016/j.chembiol.2003.08.012  PMID:15610844
    • Parrish, J. P., Trzupek, J. D., Hughes, T. V., Hwang, I., Boger, D. L. Synthesis and evaluation of N-aryl and N-alkenyl CBI derivatives Bioorganic & Medicinal Chemistry  2004 12:5845-5856  DOI:10.1016/j.bmc.2004.08.032  PMID:15498660
    • Lichtman, A. H., Leung, D., Shelton, C. C., Saghatelian, A., Hardouin, C., Boger, D. L., Cravatt, B. F. Reversible inhibitors of fatty acid amide hydrolase that promote analgesia: evidence for an unprecedented combination of potency and selectivity Journal of Pharmacology and Experimental Therapeutics  2004 311:441-448  DOI:10.1124/jpet.104.069401  PMID:15229230
    • Shin, D., Rew, Y., Boger, D. L. Total synthesis and structure of the ramoplanin A1 and A3 aglycons: two minor components of the ramoplanin complex Proceedings of the National Academy of Sciences of the United States of America  2004 101:11977-11979  DOI:10.1073/pnas.0401419101  PMID:15175429  PMCID:PMC514419
    • Lee, P. S., Du, W., Boger, D. L., Jorgensen, W. L. Energetic preferences for alpha,beta versus beta,gamma unsaturation Journal of Organic Chemistry  2004 69:5448-5453  DOI:10.1021/jo049365y  PMID:15287795
    • Ham, Y. W., Boger, D. L. A powerful selection assay for mixture libraries of DNA alkylating agents Journal of the American Chemical Society  2004 126:9194-9195  DOI:10.1021/ja0477930  PMID:15281804
    • Tichenor, M. S., Kastrinsky, D. B., Boger, D. L. Total synthesis, structure revision, and absolute configuration of (+)-yatakemycin Journal of the American Chemical Society  2004 126:8396-8398  DOI:10.1021/ja0472735  PMID:15237994
    • Lillo, A. M., Sun, C. Z., Gao, C., Ditzel, H., Parrish, J., Gauss, C. M., Moss, J., Felding-Habermann, B., Wirsching, P., Boger, D. L., Janda, K. D. A human single-chain antibody specific for integrin alpha(3)beta(1) capable of cell internalization and delivery of antitumor agents Chemistry & Biology  2004 11:897-906  DOI:10.1016/j.chembiol.2004.04.018  PMID:15271348
    • Chen, L., Yuan, Y. Q., Helm, J. S., Hu, Y. N., Rew, Y., Shin, D. W., Boger, D. L., Walker, S. Dissecting ramoplanin: mechanistic analysis of synthetic ramoplanin analogues as a guide to the design of improved antibiotics Journal of the American Chemical Society  2004 126:7462-7463  DOI:10.1021/ja047879t  PMID:15198592
    • Crowley, B. M., Mori, Y., McComas, C. C., Tang, D. T., Boger, D. L. Total synthesis of the ristocetin aglycon Journal of the American Chemical Society  2004 126:4310-4317  DOI:10.1021/ja039795a  PMID:15053621
    • Kastrinsky, D. B., Boger, D. L. Effective asymmetric synthesis of 1,2,9,9a-tetrahydrocyclopropa c benzo e indol-4-one (cbi) Journal of Organic Chemistry  2004 69:2284-2289  DOI:10.1021/jo035465x  PMID:15049620
    • Rew, Y., Shin, D., Hwang, I., Boger, D. L. Total synthesis and examination of three key analogues of ramoplanin: a lipoglycodepsipeptide with potent antibiotic activity Journal of the American Chemical Society  2004 126:1041-1043  DOI:10.1021/ja039671y  PMID:14746470
    • Parrish, J. P., Hughes, T. V., Hwang, I. Y., Boger, D. L. Establishing the parabolic relationship between reactivity and activity for derivatives and analogues of the duocarmycin and CC-1065 alkylation subunits Journal of the American Chemical Society  2004 126:80-81  DOI:10.1021/ja038162t  PMID:14709069
    • Tse, W. C., Boger, D. L. A fluorescent intercalator displacement assay for establishing DNA binding selectivity and affinity Accounts of Chemical Research  2004 37:61-69  DOI:10.1021/ar030113y  PMID:14730995
    • Desai, P., Pfeiffer, S. S., Boger, D. L. Synthesis of the chlorofusin cyclic peptide: assignment of the asparagine stereochemistry Organic Letters  2003 5:5047-5050  DOI:10.1021/ol036083g  PMID:14682761
    • Buck, S. B., Hardouin, C., Ichikawa, S., Soenen, D. R., Gauss, C. M., Hwang, I., Swingle, M. R., Bonness, K. M., Honkanen, R. E., Boger, D. L. Fundamental role of the fostriecin unsaturated lactone and implications for selective protein phosphatase inhibition Journal of the American Chemical Society  2003 125:15694-15695  DOI:10.1021/ja038672n  PMID:14677930
    • Parrish, J. P., Kastrinsky, D. B., Hwang, I., Boger, D. L. Synthesis and evaluation of duocarmycin and CC-1065 analogues incorporating the 1,2,9,9a-tetrahydrocyclopropa c benz e -3-azaindol-4-one (CBA) alkylation subunit Journal of Organic Chemistry  2003 68:8984-8990  DOI:10.1021/jo035119f  PMID:14604371
    • Bassarello, C., Cimino, P., Bifulco, G., Boger, D. L., Smith, J. A., Chazin, W. J., Gomez-Paloma, L. NMR structure of the (+)-CPI-indole/d(GACTAATTGAC)-d(GTCAATTAGTC) covalent complex ChemBioChem  2003 4:1188-1193  DOI:10.1002/cbic.200300642  PMID:14613110
    • Yeung, B. K. S., Tse, W. C., Boger, D. L. Determination of binding affinities of triplex forming oligonucleotides using a fluorescent intercalator displacement (FID) assay Bioorganic & Medicinal Chemistry Letters  2003 13:3801-3804  DOI:10.1016/j.bmcl.2003.07.005  PMID:14552783
    • Ham, Y. W., Tse, W. C., Boger, D. L. High-resolution assessment of protein DNA binding affinity and selectivity utilizing a fluorescent intercalator displacement (FID) assay Bioorganic & Medicinal Chemistry Letters  2003 13:3805-3807  DOI:10.1016/j.bmcl.2003.06.002  PMID:14552784
    • Marsilje, T. H., Hedrick, M. P., Desharnais, J., Capps, K., Tavassoli, A., Zhang, Y., Wilson, I. A., Benkovic, S. J., Boger, D. L. 10-(2-benzoxazolcarbonyl)-5,10-dideaza-acyclic-5,6,7,8-tetrahydrofolic acid: a potential inhibitor of GAR transformylase and AICAR transformylase Bioorganic & Medicinal Chemistry  2003 11:4503-4509  DOI:10.1016/s0968-0896(03)00457-7  PMID:13129586
    • Tse, W. C., Ishii, T., Boger, D. L. Comprehensive high-resolution analysis of hairpin polyamides utilizing a fluorescent intercalator displacement (FID) assay Bioorganic & Medicinal Chemistry  2003 11:4479-4486  DOI:10.1016/s0968-0896(03)00455-3  PMID:13129584
    • Desharnais, J., Hwang, I., Zhang, Y., Tavassoli, A., Baboval, J., Benkovic, S. J., Wilson, I. A., Boger, D. L. Design, synthesis and biological evaluation of 10-CF3CO-DDACTHF analogues and derivatives as inhibitors of GAR Tfase and the de novo purine biosynthetic pathway Bioorganic & Medicinal Chemistry  2003 11:4511-4521  DOI:10.1016/s0968-0896(03)00458-9  PMID:13129587
    • Marsilje, T. H., Hedrick, M. P., Desharnais, J., Tavassoli, A., Zhang, Y., Wilson, I. A., Benkovic, S. J., Boger, D. L. Design, synthesis, and biological evaluation of simplified alpha-keto heterocycle, trifluoromethyl ketone, and formyl substituted folate analogues as potential inhibitors of GAR transformylase and AICAR transformylase Bioorganic & Medicinal Chemistry  2003 11:4487-4501  DOI:10.1016/s0968-0896(03)00456-5  PMID:13129585
    • Parrish, J. P., Kastrinsky, D. B., Wolkenberg, S. E., Igarashi, Y., Boger, D. L. DNA alkylation properties of yatakemycin Journal of the American Chemical Society  2003 125:10971-10976  DOI:10.1021/ja035984h  PMID:12952479
    • Parrish, J. P., Kastrinsky, D. B., Stauffer, F., Hedrick, M. P., Hwang, I., Boger, D. L. Establishment of substituent effects in the DNA binding subunit of CBI analogues of the duocarmycins and CC-1065 Bioorganic & Medicinal Chemistry  2003 11:3815-3838  DOI:10.1016/s0968-0896(03)00194-9  PMID:12901927
    • McComas, C. C., Crowley, B. M., Boger, D. L. Partitioning the loss in vancomycin binding affinity for D-Ala-D-Lac into lost H-bond and repulsive lone pair contributions Journal of the American Chemical Society  2003 125:9314-9315  DOI:10.1021/ja035901x  PMID:12889959
    • Parrish, J. P., Kastrinsky, D. B., Boger, D. L. Synthesis and X-ray analysis of an unprecedented and stable 2-aza-4,4-spirocyclopropacyclohexadienone Organic Letters  2003 5:2577-2579  DOI:10.1021/ol035000t  PMID:12841785
    • Yeung, B. K. S., Boger, D. L. Synthesis of isochrysohermidin-distamycin hybrids Journal of Organic Chemistry  2003 68:5249-5253  DOI:10.1021/jo034326c  PMID:12816485
    • Leung, D., Hardouin, C., Boger, D. L., Cravatt, B. F. Discovering potent and selective reversible inhibitors of enzymes in complex proteomes Nature Biotechnology  2003 21:687-691  DOI:10.1038/nbt826  PMID:12740587
    • Zhang, Y., Desharnais, J., Marsilje, T. H., Li, C. L., Hedrick, M. P., Gooljarsingh, L. T., Tavassoli, A., Benkovic, S. J., Olson, A. J., Boger, D. L., Wilson, I. A. Rational design, synthesis, evaluation, and crystal structure of a potent inhibitor of human GAR Tfase: 10-(trifluoroacetyl)-5,10-dideazaacyclic-5,6,7,8-tetrahydrofolic acid Biochemistry  2003 42:6043-6056  DOI:10.1021/bi034219c  PMID:12755606
    • Soenen, D. R., Hwang, I., Hedrick, M. P., Boger, D. L. Multidrug resistance reversal activity of key ningalin analogues Bioorganic & Medicinal Chemistry Letters  2003 13:1777-1781  DOI:10.1016/s0960-894x(03)00294-4  PMID:12729663
    • Krenitsky, P. J., Boger, D. L. Synthesis of the (S,S,S)-diastereomer of the 15-membered biaryl ring system of RP 66453 Tetrahedron Letters  2003 44:4019-4022  DOI:10.1016/s0040-4039(03)00856-6
    • Soenen, D. R., Zimpleman, J. M., Boger, D. L. Synthesis and inverse electron demand Diels-Alder reactions of 3,6-bis(3,4-dimethoxybenzoyl)-1,2,4,5-tetrazine Journal of Organic Chemistry  2003 68:3593-3598  DOI:10.1021/jo020713v  PMID:12713365
    • Boger, D. L. Solution-phase synthesis of combinatorial libraries designed to modulate protein-protein or protein-DNA interactions Bioorganic & Medicinal Chemistry  2003 11:1607-1613  DOI:10.1016/s0968-0896(03)00031-2  PMID:12659745
    • Wanner, J., Tang, D. T., McComas, C. C., Crowley, B. M., Jiang, W. L., Moss, J., Boger, D. L. A new and improved method for deglycosidation of glycopeptide antibiotics exemplified with vancomycin, ristocetin, and ramoplanin Bioorganic & Medicinal Chemistry Letters  2003 13:1169-1173  DOI:10.1016/s0960-894x(03)00051-9  PMID:12643936
    • Jiang, W. L., Wanner, J., Bounaud, P. Y., Boger, D. L. Total synthesis of the ramoplanin a2 and ramoplanose aglycon Journal of the American Chemical Society  2003 125:1877-1887  DOI:10.1021/ja0212314  PMID:12580615
    • Boger, D. L., Desharnais, J., Capps, K. Solution-phase combinatorial libraries: modulating cellular signaling by targeting protein-protein or protein-DNA interactions Angewandte Chemie-International Edition  2003 42:4138-4176  DOI:10.1002/anie.200300574  PMID:14502729
    • McComas, C. C., Crowley, B. M., Hwang, I., Boger, D. L. Synthesis and evaluation of methyl ether derivatives of the vancomycin, teicoplanin, and ristocetin aglycon methyl esters Bioorganic & Medicinal Chemistry Letters  2003 13:2933-2936  DOI:10.1016/s0960-894x(03)00513-4  PMID:14611861
    • Zhang, Y., Desharnais, J., Greasley, S. E., Beardsley, G. P., Boger, D. L., Wilson, I. A. Crystal structures of human GAR Tfase at low and high pH and with substrate β-GAR Biochemistry  2002 41:14206-14215  DOI:10.1021/bi020522m  PMID:12450384
    • Lewy, D. S., Gauss, C. M., Soenen, D. R., Boger, D. L. Fostriecin: Chemistry and biology Current Medicinal Chemistry  2002 9:2005-2032  PMID:12369868
    • Ambroise, Y., Yaspan, B., Ginsberg, M. H., Boger, D. L. Inhibitors of cell migration that inhibit intracellular paxillin/alpha a binding: A well-documented use of positional scanning libraries Chemistry & Biology  2002 9:1219-1226  DOI:10.1016/s1074-5521(02)00246-6  PMID:12445772
    • Wolkenberg, S. E., Boger, D. L. Total synthesis of anhydrolycorinone utilizing sequential intramolecular Diels-Alder reactions of a 1,3,4-oxadiazole Journal of Organic Chemistry  2002 67:7361-7364  DOI:10.1021/jo030437k  PMID:12375965
    • Wilkie, G. D., Elliott, G. I., Blagg, B. S. J., Wolkenberg, S. E., Soenen, D. R., Miller, M. M., Pollack, S., Boger, D. L. Intramolecular Diels-Alder and tandem intramolecular Diels-Alder/1,3-dipolar cycloaddition reactions of 1,3,4-oxadiazoles Journal of the American Chemical Society  2002 124:11292-11294  DOI:10.1021/ja027533n  PMID:12236743
    • Woods, C. R., Faucher, N., Eschgfaller, B., Bair, K. W., Boger, D. L. Synthesis and DNA binding properties of saturated distamycin analogues Bioorganic & Medicinal Chemistry Letters  2002 12:2647-2650  DOI:10.1016/s0960-894x(02)00467-5  PMID:12182879
    • Woods, C. R., Ishii, T., Boger, D. L. Synthesis and DNA binding properties of iminodiacetic acid-linked polyamides: characterization of cooperative extended 2 : 1 side-by-side parallel binding Journal of the American Chemical Society  2002 124:10676-10682  DOI:10.1021/ja026588m  PMID:12207521
    • Blagg, B. S. J., Boger, D. L. Total synthesis of (+)-camptothecin Tetrahedron  2002 58:6343-6349  DOI:10.1016/s0040-4020(02)00633-6
    • Marsilje, T. H., Labroli, M. A., Hedrick, M. P., Jin, Q., Desharnais, J., Baker, S. J., Gooljarsingh, L. T., Ramcharan, J., Tavassoli, A., Zhang, Y., Wilson, I. A., Beardsley, G. P., et al. 10-formyl-5,10-dideaza-acyclic-5,6,7,8-tetrahydrofolic acid (10-formyl-DDACTHF): a potent cytotoxic agent acting by selective inhibition of human GAR Tfase and the de novo purine biosynthetic pathway Bioorganic & Medicinal Chemistry  2002 10:2739-2749  DOI:10.1016/s0968-0896(02)00102-5  PMID:12057663
    • Wolkenberg, S. E., Boger, D. L. Mechanisms of in situ activation for DNA-targeting antitumor agents Chemical Reviews  2002 102:2477-2495  DOI:10.1021/cr010046q  PMID:12105933
    • Chen, Y., Bilban, M., Foster, C. A., Boger, D. L. Solution-phase parallel synthesis of a pharmacophore library of hun-7293 analogues: a general chemical mutagenesis approach to defining structure-function properties of naturally occurring cyclic (depsi)peptides Journal of the American Chemical Society  2002 124:5431-5440  DOI:10.1021/ja020166v  PMID:11996584
    • Jiang, W. L., Wanner, J., Bounaud, P. Y., Boger, D. L. Total synthesis of the ramoplanin a2 and ramoplanose aglycon Journal of the American Chemical Society  2002 124:5288-5290  DOI:10.1021/ja020237q  PMID:11996568
    • McAtee, J. J., Castle, S. L., Jin, Q., Boger, D. L. Synthesis and evaluation of vancomycin and vancomycin aglycon analogues that bear modifications in the residue 3 asparagine Bioorganic & Medicinal Chemistry Letters  2002 12:1319-1322  DOI:10.1016/s0960-894x(02)00130-0  PMID:11965380
    • Berg, T., Cohen, S. B., Desharnais, J., Sonderegger, C., Maslyar, D. J., Goldberg, J., Boger, D. L., Vogt, P. K. Small-molecule antagonists of Myc/Max dimerization inhibit Myc-induced transformation of chicken embryo fibroblasts Proceedings of the National Academy of Sciences of the United States of America  2002 99:3830-3835  DOI:10.1073/pnas.062036999  PMID:11891322  PMCID:PMC122609
    • Woods, C. R., Ishii, T., Wu, B., Bair, K. W., Boger, D. L. Hairpin versus extended DNA binding of a substituted beta-alanine linked polyamide Journal of the American Chemical Society  2002 124:2148-2152  DOI:10.1021/ja0122039  PMID:11878968
    • Ambroise, Y., Boger, D. L. The DNA phosphate backbone is not involved in catalysis of the duocarmycin and CC-1065 DNA alkylation reaction Bioorganic & Medicinal Chemistry Letters  2002 12:303-306  DOI:10.1016/s0960-894x(01)00740-5  PMID:11814783
    • Goldberg, J., Jin, Q., Ambroise, Y., Satoh, S., Desharnais, J., Capps, K., Boger, D. L. Erythropoietin mimetics derived from solution phase combinatorial libraries Journal of the American Chemical Society  2002 124:544-555  DOI:10.1021/ja0118789  PMID:11804483
    • Krenitsky, P. J., Boger, D. L. Preparation of the 14-membered L,L-cycloisodityrosine subunit of RP 66453 Tetrahedron Letters  2002 43:407-410  DOI:10.1016/s0040-4039(01)02194-3
    • Greasley, S. E., Marsilje, T. H., Cai, H., Baker, S., Benkovic, S. J., Boger, D. L., Wilson, I. A. Unexpected formation of an epoxide-derived multisubstrate adduct inhibitor on the active site of GAR transformylase Biochemistry  2001 40:13538-13547  DOI:10.1021/bi011482+  PMID:11695901
    • Boger, D. L., Schmitt, H. W., Fink, B. E., Hedrick, M. P. Parallel synthesis and evaluation of 132 (+)-1,2,9,9a-tetrahydrocyclopropa c benz e indol-4-one (CBI) analogues of CC-1065 and the duocarmycins defining the contribution of the DNA-binding domain Journal of Organic Chemistry  2001 66:6654-6661  DOI:10.1021/jo010454u  PMID:11578217
    • Fedorova, I., Hashimoto, A., Fecik, R. A., Hedrick, M. P., Hanus, L. O., Boger, D. L., Rice, K. C., Basile, A. S. Behavioral evidence for the interaction of oleamide with multiple neurotransmitter systems Journal of Pharmacology and Experimental Therapeutics  2001 299:332-342  PMID:11561096
    • Ellis, D. A., Wolkenberg, S. E., Boger, D. L. Metal cation complexation and activation of reversed CPyi analogues of CC-1065 and duocarmycin SA: Partitioning the effects of binding and catalysis Journal of the American Chemical Society  2001 123:9299-9306  DOI:10.1021/ja010769r  PMID:11562212
    • Boger, D. L.*, Hong, J. Y.* Asymmetric total synthesis of ent-(-)-roseophilin: Assignment of absolute configuration Journal of the American Chemical Society  2001 123:8515-8519  DOI:10.1021/ja011271s  PMID:11525659 (* = equal contribution)
    • Boger, D. L.*, Tse, W. C.* Thiazole orange as the fluorescent intercalator in a high resolution fid assay for determining DNA binding affinity and sequence selectivity of small molecules Bioorganic & Medicinal Chemistry  2001 9:2511-2518  DOI:10.1016/s0968-0896(01)00243-7  PMID:11553493 (* = equal contribution)
    • Boger, D. L. Vancomycin, teicoplanin, and ramoplanin: Synthetic and mechanistic studies Medicinal Research Reviews  2001 21:356-381  DOI:10.1002/med.1014  PMID:11579438
    • Mori, Y., McAtee, J. J., Rogel, O., Boger, D. L. Alternative synthesis and thermal atropisomerism of a fully functionalized DEFG ring system of teicoplanin Tetrahedron Letters  2001 42:6061-6064  DOI:10.1016/s0040-4039(01)01199-6
    • Boger, D. L., Stauffer, F., Hedrick, M. P. Substituent effects within the DNA binding subunit of CBI analogues of the duocarmycins and CC-1065 Bioorganic & Medicinal Chemistry Letters  2001 11:2021-2024  DOI:10.1016/s0960-894x(01)00372-9  PMID:11454471
    • Boger, D. L., Brunette, S. R., Garbaccio, R. M. Synthesis and evaluation of a series of C3-substituted CBI analogues of CC-1065 and the duocarmycins Journal of Organic Chemistry  2001 66:5163-5173  DOI:10.1021/jo010309g  PMID:11463270
    • Boger, D. L., Fink, B. E., Brunette, S. R., Tse, W. C., Hedrick, M. P. A simple, high-resolution method for establishing DNA binding affinity and sequence selectivity Journal of the American Chemical Society  2001 123:5878-5891  DOI:10.1021/ja010041a  PMID:11414820
    • Boger, D. L., Miyauchi, H., Hedrick, M. P. Alpha-Keto heterocycle inhibitors of fatty acid amide hydrolase: carbonyl group modification and alpha-substitution Bioorganic & Medicinal Chemistry Letters  2001 11:1517-1520  DOI:10.1016/s0960-894x(01)00211-6  PMID:11412972
    • Boger, D. L. Recent advances in bioorganic and medicinal chemistry. Preface. Bioorganic & Medicinal Chemistry Letters  2001 11:ix  DOI:10.1016/s0960-894x(01)00337-7
    • Boger, D. L., Ichikawa, S., Zhong, W. Total synthesis of fostriecin (CI-920) Journal of the American Chemical Society  2001 123:4161-4167  DOI:10.1021/ja010195q  PMID:11457179
    • Boger, D. L., Hughes, T. V., Hedrick, M. P. Synthesis, chemical properties, and biological evaluation of CC-1065 and duocarmycin analogues incorporating the 5-methoxycarbonyl-1,2,9,9a-tetrahydrocyclopropa c benz e indol-4-one alkylation subunit Journal of Organic Chemistry  2001 66:2207-2216  DOI:10.1021/jo001772g  PMID:11281757
    • Boger, D. L., Kim, S. H., Mori, Y., Weng, J. H., Rogel, O., Castle, S. L., McAtee, J. J. First and second generation total synthesis of the teicoplanin aglycon Journal of the American Chemical Society  2001 123:1862-1871  DOI:10.1021/ja003835i  PMID:11456806
    • Boger, D. L.*, Goldberg, J.* Cytokine receptor dimerization and activation: prospects for small molecule agonists Bioorganic & Medicinal Chemistry  2001 9:557-562  DOI:10.1016/s0968-0896(00)00276-5  PMID:11310589 (* = equal contribution)
    • Boger, D. L.*, Goldberg, J.*, Silletti, S., Kessler, T., Cheresh, D. A. Identification of a novel class of small-molecule antiangiogenic agents through the screening of combinatorial libraries which function by inhibiting the binding and localization of proteinase MMP2 to integrin alpha(V)beta(3) Journal of the American Chemical Society  2001 123:1280-1288  DOI:10.1021/ja003579+  PMID:11456699 (* = equal contribution)
    • Boger, D. L., Ichikawa, S., Tse, W. C., Hedrick, M. P., Jin, Q. Total syntheses of thiocoraline and be-22179 and assessment of their DNA binding and biological properties Journal of the American Chemical Society  2001 123:561-568  DOI:10.1021/ja003602r  PMID:11456568
    • Silletti, S., Kessler, T., Goldberg, J., Boger, D. L., Cheresh, D. A. Disruption of matrix metalloproteinase 2 binding to integrin alpha(v)beta(3) by an organic molecule inhibits angiogenesis and tumor growth in vivo Proceedings of the National Academy of Sciences of the United States of America  2001 98:119-124  DOI:10.1073/pnas.011343298  PMID:11134507  PMCID:PMC14554
    • Boger, D. L.*, Wolkenberg, S. E.* Total synthesis of Amaryllidaceae alkaloids utilizing sequential intramolecular heterocyclic azadiene Diels-Alder reactions of an unsymmetrical 1,2,4,5-tetrazine Journal of Organic Chemistry  2000 65:9120-9124  DOI:10.1021/jo0012546  PMID:11149859 (* = equal contribution)
    • Boger, D. L., Ichikawa, S., Jiang, H. J. Total synthesis of the rubrolone aglycon Journal of the American Chemical Society  2000 122:12169-12173  DOI:10.1021/ja002997b
    • Boger, D. L., Fecik, R. A., Patterson, J. E., Miyauchi, H., Patricelli, M. P., Cravatt, B. F. Fatty acid amide hydrolase substrate specificity Bioorganic & Medicinal Chemistry Letters  2000 10:2613-2616  DOI:10.1016/s0960-894x(00)00528-x  PMID:11128635
    • Boger, D. L., Aquila, B. M., Tse, W. C., Searcey, M. Synthesis and evaluation of a novel bleomycin A(2) analogue: Continuing assessment of the linker domain Tetrahedron Letters  2000 41:9493-9498  DOI:10.1016/s0040-4039(00)01633-6
    • Boger, D. L., Weng, J. H., Miyazaki, S., McAtee, J. J., Castle, S. L., Kim, S. H., Mori, Y., Rogel, O., Strittmatter, H., Jin, Q. Thermal atropisomerism of teicoplanin aglycon derivatives: Preparation of the P,P,P and M,P,P atropisomers of the teicoplanin aglycon via selective equilibration of the DE ring system Journal of the American Chemical Society  2000 122:10047-10055  DOI:10.1021/ja002376i
    • Boger, D. L., Lee, R. J., Bounaud, P. Y., Meier, P. Asymmetric synthesis of orthogonally protected L-threo-beta-hydroxyasparagine Journal of Organic Chemistry  2000 65:6770-6772  DOI:10.1021/jo000628s  PMID:11052134
    • Boger, D. L., Lee, J. K. Development of a solution-phase synthesis of minor groove binding bis-intercalators based on triostin A suitable for combinatorial synthesis Journal of Organic Chemistry  2000 65:5996-6000  DOI:10.1021/jo000382r  PMID:10987932
    • Boger, D. L., Chen, Y., Foster, C. A. Synthesis and evaluation of aza HUN-7293 Bioorganic & Medicinal Chemistry Letters  2000 10:1741-1744  DOI:10.1016/s0960-894x(00)00336-x  PMID:10937737
    • Boger, D. L., Kim, S. H., Miyazaki, S., Strittmatter, H., Weng, J. H., Mori, Y., Rogel, O., Castle, S. L., McAtee, J. J. Total synthesis of the teicoplanin aglycon Journal of the American Chemical Society  2000 122:7416-7417  DOI:10.1021/ja001663j
    • Boger, D. L., Dechantsreiter, M. A., Ishii, T., Fink, B. E., Hedrick, M. P. Assessment of solution-phase positional scanning libraries based on distamycin A for the discovery of new DNA binding agents Bioorganic & Medicinal Chemistry  2000 8:2049-2057  DOI:10.1016/s0968-0896(00)00137-1  PMID:11003149
    • Smith, J. A., Bifulco, G., Case, D. A., Boger, D. L., Gomez-Paloma, L., Chazin, W. J. The structural basis for in situ activation of DNA alkylation by duocarmycin sa Journal of Molecular Biology  2000 300:1195-1204  DOI:10.1006/jmbi.2000.3887  PMID:10903864
    • Boger, D. L., Fink, B. E., Hedrick, M. P. Total synthesis of distamycin A and 2640 analogues: A solution-phase combinatorial approach to the discovery of new, bioactive DNA binding agents and development of a rapid, high-throughput screen for determining relative DNA binding affinity or DNA binding sequence selectivity Journal of the American Chemical Society  2000 122:6382-6394  DOI:10.1021/ja994192d
    • Boger, D. L.*, Wolkenberg, S. E.*, Boyce, C. W. A new method of in situ activation for a novel class of DNA alkylating agents: tunable metal cation complexation and activation Journal of the American Chemical Society  2000 122:6325-6326  DOI:10.1021/ja000653f (* = equal contribution)
    • Boger, D. L., Marsilje, T. H., Castro, R. A., Hedrick, M. P., Jin, Q., Baker, S. J., Shim, J. H., Benkovic, S. J. Design, synthesis, and biological evaluation of fluoronitrophenyl substituted folate analogues as potential inhibitors of GAR transformylase and AICAR transformylase Bioorganic & Medicinal Chemistry Letters  2000 10:1471-1475  DOI:10.1016/s0960-894x(00)00271-7  PMID:10888335
    • Boger, D. L.*, Boyce, C. W.* Selective metal cation activation of a DNA alkylating agent: Synthesis and evaluation of methyl 1,2,9,9a-Tetrahydrocyclopropa c pyrido 3,2-e indol-4-one-7-carboxylate (CPyl) Journal of Organic Chemistry  2000 65:4088-4100  DOI:10.1021/jo000177b  PMID:10866626 (* = equal contribution)
    • Boger, D. L., Santillan, A., Searcey, M., Brunette, S. R., Wolkenberg, S. E., Hedrick, M. P., Jin, Q. Synthesis and evaluation of 1,2,8, 8a-Tetrahydrocyclopropa[c]pyrrolo[3,2-e]indol-4(5H)-one, the parent alkylation subunit of CC-1065 and the duocarmycins: impact of the alkylation subunit substituents and its implications for DNA alkylation catalysis Journal of Organic Chemistry  2000 65:4101-4111  DOI:10.1021/jo000297j  PMID:10866627
    • Boger, D. L., Fink, B. E., Hedrick, M. P. A new class of highly cytotoxic diketopiperazines Bioorganic & Medicinal Chemistry Letters  2000 10:1019-1020  DOI:10.1016/s0960-894x(00)00152-9  PMID:10843206
    • Boger, D. L., Sato, H., Lerner, A. E., Hedrick, M. P., Fecik, R. A., Miyauchi, H., Wilkie, G. D., Austin, B. J., Patricelli, M. P., Cravatt, B. F. Exceptionally potent inhibitors of fatty acid amide hydrolase: the enzyme responsible for degradation of endogenous oleamide and anandamide Proceedings of the National Academy of Sciences of the United States of America  2000 97:5044-5049  DOI:10.1073/pnas.97.10.5044  PMID:10805767  PMCID:PMC25778
    • Boger, D. L., Labroli, M. A., Marsilje, T. H., Jin, Q., Hedrick, M. P., Baker, S. J., Shim, J. H., Benkovic, S. J. Conformationally restricted analogues designed for selective inhibition of GAR Tfase versus thymidylate synthase or dihydrofolate reductase Bioorganic & Medicinal Chemistry  2000 8:1075-1086  DOI:10.1016/s0968-0896(00)00051-1  PMID:10882019
    • Boger, D. L.*, Soenen, D. R.*, Boyce, C. W., Hedrick, M. P., Jin, Q. Total synthesis of ningalin B utilizing a heterocyclic azadiene Diels-Alder reaction and discovery of a new class of potent multidrug resistant (MDR) reversal agents Journal of Organic Chemistry  2000 65:2479-2483  DOI:10.1021/jo9916535  PMID:10789460 (* = equal contribution)
    • Boger, D. L., Ichikawa, S. Total syntheses of thiocoraline and be-22179: Establishment of relative and absolute stereochemistry Journal of the American Chemical Society  2000 122:2956-2957  DOI:10.1021/ja0001660
    • Boger, D. L., Lee, J. K., Goldberg, J., Jin, Q. Two comparisons of the performance of positional scanning and deletion synthesis for the identification of active constituents in mixture combinatorial libraries Journal of Organic Chemistry  2000 65:1467-1474  DOI:10.1021/jo9916481  PMID:10814111
    • Boger, D. L., Searcey, M., Tse, W. C., Jin, Q. Bifunctional alkylating agents derived from duocarmycin SA: Potent antitumor activity with altered sequence selectivity Bioorganic & Medicinal Chemistry Letters  2000 10:495-498  DOI:10.1016/s0960-894x(00)00042-1  PMID:10743956
    • Boger, D. L.*, Goldberg, J.*, Satoh, S., Ambroise, Y., Cohen, S. B., Vogt, P. K. Non-amide-based combinatorial libraries derived from N-BOC-iminodiacetic acid: solution-phase synthesis of piperazinone libraries with activity against LEF-1/β-catenin-mediated transcription Helvetica Chimica Acta  2000 83:1825-1845  DOI:10.1002/1522-2675(20000809)83:8<1825::aid-hlca1825>3.0.co;2-4 (* = equal contribution)
    • Greasley, S. E., Yamashita, M. M., Cai, H., Benkovic, S. J., Boger, D. L., Wilson, I. A. New insights into inhibitor design from the crystal structure and NMR studies of escherichia coli GAR and 10-formyl-5,8,10-trideazafolic acid Biochemistry  1999 38:16783-16793  DOI:10.1021/bi991888a  PMID:10606510
    • Boger, D. L., Ledeboer, M. W., Kume, M., Searcey, M., Jin, Q. Total synthesis and comparative evaluation of luzopeptin A-C and quinoxapeptin A-C Journal of the American Chemical Society  1999 121:11375-11383  DOI:10.1021/ja993019e
    • Boger, D. L.*, Garbaccio, R. M.* Shape-dependent catalysis: Insights into the source of catalysis for the CC-1065 and duocarmycin DNA alkylation reaction Accounts of Chemical Research  1999 32:1043-1052  DOI:10.1021/ar9800946 (* = equal contribution)
    • Baraldi, P. G., Cacciari, B., Romagnoli, R., Spalluto, G., Boyce, C. W., Boger, D. L. Resolution of a CPzl precursor, synthesis and biological evaluation of (+) and (-)-NBoc-CPzl: a further validation of the relationship between chemical solvolytic stability and cytotoxicity Bioorganic & Medicinal Chemistry Letters  1999 9:3087-3092  DOI:10.1016/s0960-894x(99)00533-8  PMID:10560730
    • Boger, D. L.*, Garbaccio, R. M.* A novel class of CC-1065 and duocarmycin analogues subject to mitomycin-related reductive activation Journal of Organic Chemistry  1999 64:8350-8362  DOI:10.1021/jo991301y  PMID:11674758 (* = equal contribution)
    • Boger, D. L., Jiang, W. Q., Goldberg, J. Convergent solution-phase combinatorial synthesis with multiplication of diversity through rigid biaryl and diarylacetylene couplings Journal of Organic Chemistry  1999 64:7094-7100  DOI:10.1021/jo990639p
    • Boger, D. L.*, Garbaccio, R. M.* Are the duocarmycin and CC-1065 DNA alkylation reactions acid-catalyzed? Solvolysis pH-rate profiles suggest they are not Journal of Organic Chemistry  1999 64:5666-5669  DOI:10.1021/jo990762g  PMID:11674637 (* = equal contribution)
    • Boger, D. L., Santillan, A., Searcey, M., Jin, Q. Synthesis and evaluation of duocarmycin and CC-1065 analogues containing modifications in the subunit linking amide Journal of Organic Chemistry  1999 64:5241-5244  DOI:10.1021/jo990452y
    • Boger, D. L., Keim, H., Oberhauser, B., Schreiner, E. P., Foster, C. A. Total synthesis of HUN-7293 Journal of the American Chemical Society  1999 121:6197-6205  DOI:10.1021/ja990918u
    • Schnell, J. R., Ketchem, R. R., Boger, D. L., Chazin, W. J. Binding-induced activation of DNA alkylation by duocarmycin SA: Insights from the structure of an indole derivative-DNA adduct Journal of the American Chemical Society  1999 121:5645-5652  DOI:10.1021/ja983556j
    • Boger, D. L., Sato, H., Lerner, A. E., Guan, X. J., Gilula, N. B. Arachidonic acid amide inhibitors of gap junction cell-cell communication Bioorganic & Medicinal Chemistry Letters  1999 9:1151-1154  DOI:10.1016/s0960-894x(99)00148-1  PMID:10328303
    • Boger, D. L., Miyazaki, S., Kim, S. H., Wu, J. H., Loiseleur, O., Castle, S. L. Diastereoselective total synthesis of the vancomycin aglycon with ordered atropisomer equilibrations Journal of the American Chemical Society  1999 121:3226-3227  DOI:10.1021/ja990189i
    • Boger, D. L.*, Goldberg, J.*, Andersson, C. M. Solution phase combinatorial synthesis of biaryl libraries employing heterogeneous conditions for catalysis and isolation with size exclusion chromatography for purification Journal of Organic Chemistry  1999 64:2422-2427  DOI:10.1021/jo982234v (* = equal contribution)
    • Boger, D. L.*, Hong, J.*, Hikota, M., Ishida, M. Total synthesis of phomazarin Journal of the American Chemical Society  1999 121:2471-2477  DOI:10.1021/ja983631q (* = equal contribution)
    • Wilcox, B. J., Ritenour-Rodgers, K. J., Asser, A. S., Baumgart, L. E., Baumgart, M. A., Boger, D. L., DeBlassio, J. L., deLong, M. A., Glufke, U., Henz, M. E., King, L., Merkler, K. A., et al. N-acylglycine amidation: implications for the biosynthesis of fatty acid primary amides Biochemistry  1999 38:3235-3245  DOI:10.1021/bi982255j  PMID:10079066
    • Boger, D. L., Ledeboer, M. W., Kume, M. Total synthesis of luzopeptins A-C Journal of the American Chemical Society  1999 121:1098-1099  DOI:10.1021/ja983925b
    • Boger, D. L., Saionz, K. W. DNA binding properties of key sandramycin analogues: systematic examination of the intercalation chromophore Bioorganic & Medicinal Chemistry  1999 7:315-321  DOI:10.1016/s0968-0896(98)00206-5  PMID:10218823
    • Boger, D. L., Sato, H., Lerner, A. E., Austin, B. J., Patterson, J. E., Patricelli, M. P., Cravatt, B. F. Trifluoromethyl ketone inhibitors of fatty acid amide hydrolase: a probe of structural and conformational features contributing to inhibition Bioorganic & Medicinal Chemistry Letters  1999 9:265-270  DOI:10.1016/s0960-894x(98)00734-3  PMID:10021942
    • Boger, D. L.*, Boyce, C. W.*, Labroli, M. A., Sehon, C. A., Jin, Q. Total syntheses of ningalin A, lamellarin O, lukianol A, and permethyl storniamide A utilizing heterocyclic azadiene Diels-Alder reactions Journal of the American Chemical Society  1999 121:54-62  DOI:10.1021/ja982078+ (* = equal contribution)
    • Boger, D. L.*, Castle, S. L.*, Miyazaki, S., Wu, J. H., Beresis, R. T., Loiseleur, O. Vancomycin CD and DE macrocyclization and atropisomerism studies Journal of Organic Chemistry  1999 64:70-80  DOI:10.1021/jo980880o  PMID:11674087 (* = equal contribution)
    • Boger, D. L., Cai, H. Bleomycin: synthetic and mechanistic studies Angewandte Chemie-International Edition  1999 38:448-476  DOI:10.1002/(sici)1521-3773(19990215)38:4<448::aid-anie448>3.0.co;2-w
    • Boger, D. L.*, Boyce, C. W.*, Garbaccio, R. M., Searcey, M., Jin, Q. CBI prodrug analogs of CC-1065 and the duocarmycins Synthesis-Stuttgart  1999 1505-1509 (* = equal contribution)
    • Boger, D. L., Ledeboer, M. W., Kume, M., Jin, Q. Total synthesis of quinoxapeptin A-C: Establishment of absolute stereochemistry Angewandte Chemie-International Edition  1999 38:2424-2426  DOI:10.1002/(sici)1521-3773(19990816)38:16<2424::aid-anie2424>3.0.co;2-9  PMID:10458810
    • Boger, D. L., Miyazaki, S., Kim, S. H., Wu, J. H., Castle, S. L., Loiseleur, O., Jin, Q. Total synthesis of the vancomycin aglycon Journal of the American Chemical Society  1999 121:10004-10011  DOI:10.1021/ja992577q
    • Boger, D. L., Santillan, A., Searcey, M., Jin, Q. Critical role of the linking amide in CC-1065 and the duocarmycins: implications on the source of DNA alkylation catalysis Journal of the American Chemical Society  1998 120:11554-11557  DOI:10.1021/ja9818093
    • Boger, D. L., Turnbull, P. Synthesis and evaluation of a carbocyclic analogue of the CC-1065 and duocarmycin alkylation subunits: role of the vinylogous amide and implications on DNA alkylation catalysis Journal of Organic Chemistry  1998 63:8004-8011  DOI:10.1021/jo981698q
    • Boger, D. L., Ramsey, T. M., Cai, H., Hoehn, S. T., Stubbe, J. A. A systematic evaluation of the bleomycin A(2) L-threonine side chain: its role in preorganization of a compact conformation implicated in sequence-selective DNA cleavage Journal of the American Chemical Society  1998 120:9139-9148  DOI:10.1021/ja9816638
    • Boger, D. L., Ramsey, T. M., Cai, H., Hoehn, S. T., Stubbe, J. Definition of the effect and role of the bleomycin A(2) valerate substituents: preorganization of a rigid, compact conformation implicated in sequence-selective DNA cleavage Journal of the American Chemical Society  1998 120:9149-9158  DOI:10.1021/ja9816640
    • Boger, D. L., Miyazaki, S., Loiseleur, O., Beresis, R. T., Castle, S. L., Wu, J. H., Jin, Q. Thermal atropisomerism of aglucovancomycin derivatives: preparation of (M,M,M)- and (P,M,M)-aglucovancomycins Journal of the American Chemical Society  1998 120:8920-8926  DOI:10.1021/ja981928i
    • Boger, D. L. Combinatorial chemistry Bioorganic & Medicinal Chemistry Letters  1998 8:VII-VII  DOI:10.1016/s0960-894x(98)90007-5
    • Boger, D. L., Ducray, P., Chai, W. Y., Jiang, W. Q., Goldberg, J. Higher order iminodiacetic acid libraries for probing protein-protein interactions Bioorganic & Medicinal Chemistry Letters  1998 8:2339-2344  DOI:10.1016/s0960-894x(98)00423-5  PMID:9873538
    • Boger, D. L., Schaum, R. P., Garbaccio, R. M. Regioselective inverse electron demand Diels-Alder reactions of N-acyl 6-amino-3-(methylthio)-1,2,4,5-tetrazines Journal of Organic Chemistry  1998 63:6329-6337  DOI:10.1021/jo980795g  PMID:11672266
    • Boger, D. L., Schule, G. Synthesis of acyclic precursors to (3S,4S)-4-hydroxy-2,3,4,5-tetrahydro-pyridazine-3-carboxylic acid and incorporation into a luzopeptin/quinoxapeptin dipeptide Journal of Organic Chemistry  1998 63:6421-6424  DOI:10.1021/jo980765d  PMID:11672282
    • Boger, D. L. Heterocyclic and acyclic azadiene Diels-Alder reactions: total synthesis of nothapodytine B Journal of Heterocyclic Chemistry  1998 35:1003-1011  DOI:10.1002/jhet.5570350502
    • Boger, D. L.*, Goldberg, J.*, Jiang, W. Q., Chai, W. Y., Ducray, P., Lee, J. K., Ozer, R. S., Andersson, C. M. Higher order iminodiacetic acid libraries for probing protein-protein interactions Bioorganic & Medicinal Chemistry  1998 6:1347-1378  DOI:10.1016/s0968-0896(98)00128-x  PMID:9784874 (* = equal contribution)
    • Boger, D. L., Henriksen, S. J., Cravatt, B. F. Oleamide: an endogenous sleep-inducing lipid and prototypical member of a new class of biological signaling molecules Current Pharmaceutical Design  1998 4:303-314  PMID:10197045
    • Boger, D. L., Chai, W. Y., Jin, Q. Multistep convergent solution-phase combinatorial synthesis and deletion synthesis deconvolution Journal of the American Chemical Society  1998 120:7220-7225  DOI:10.1021/ja9803557
    • Boger, D. L., Kochanny, M. J., Cai, H., Wyatt, D., Kitos, P. A., Warren, M. S., Ramcharan, J., Gooljarsingh, L. T., Benkovic, S. J. Design, synthesis, and evaluation of potential GAR and AICAR transformylase inhibitors Bioorganic & Medicinal Chemistry  1998 6:643-659  DOI:10.1016/s0968-0896(98)00040-6  PMID:9681131
    • Boger, D. L.*, Patterson, J. E.*, Guan, X., Cravatt, B. F., Lerner, R. A., Gilula, N. B. Chemical requirements for inhibition of gap junction communication by the biologically active lipid oleamide Proceedings of the National Academy of Sciences of the United States of America  1998 95:4810-4815  DOI:10.1073/pnas.95.9.4810  PMID:9560184  PMCID:PMC20169 (* = equal contribution)
    • Boger, D. L., Chai, W. Y. Solution-phase combinatorial synthesis: Convergent multiplication of diversity via the olefin metathesis reaction Tetrahedron  1998 54:3955-3970  DOI:10.1016/s0040-4020(98)00128-8
    • Boger, D. L.*, Boyce, C. W.*, Garbaccio, R. M., Searcey, M. Synthesis of CC-1065 and duocarmycin analogs via intramolecular aryl radical cyclization of a tethered vinyl chloride Tetrahedron Letters  1998 39:2227-2230  DOI:10.1016/s0040-4039(98)00232-9 (* = equal contribution)
    • Boger, D. L.*, Patterson, J. E.*, Jin, Q. Structural requirements for 5-HT2A and 5-HT1A serotonin receptor potentiation by the biologically active lipid oleamide Proceedings of the National Academy of Sciences of the United States of America  1998 95:4102-4107  DOI:10.1073/pnas.95.8.4102  PMID:9539697 (* = equal contribution)
    • Boger, D. L., Beresis, R. T., Loiseleur, O., Wu, J. H., Castle, S. L. Synthesis of the vancomycin CDE ring system Bioorganic & Medicinal Chemistry Letters  1998 8:721-724  DOI:10.1016/s0960-894x(98)00110-3  PMID:9871529
    • Wu, W., Vanderwall, D. E., Teramoto, S., Lui, S. M., Hoehn, S. T., Tang, X. J., Turner, C. J., Boger, D. L., Kozarich, J. W., Stubbe, J. NMR studies of Co.deglycoBleomycin A2 green and its complex with d(CCAGGCCTGG) Journal of the American Chemical Society  1998 120:2239-2250  DOI:10.1021/ja972125i
    • Patricelli, M. P., Patterson, J. E., Boger, D. L., Cravatt, B. F. An endogenous sleep-inducing compound is a novel competitive inhibitor of fatty acid amide hydrolase Bioorganic & Medicinal Chemistry Letters  1998 8:613-618  DOI:10.1016/s0960-894x(98)00073-0  PMID:9871570
    • Boger, D. L.*, Hong, J. Y.* Total synthesis of nothapodytine B and (-)-mappicine Journal of the American Chemical Society  1998 120:1218-1222  DOI:10.1021/ja973007y (* = equal contribution)
    • Boger, D. L., Ramsey, T. M., Cai, H., Hoehn, S. T., Kozarich, J. W., Stubbe, J. Assessment of the role of the bleomycin A(2) pyrimidoblamic acid C4 amino group Journal of the American Chemical Society  1998 120:53-65  DOI:10.1021/ja971889v
    • Boger, D. L., Chen, J. H., Saionz, K. W., Jin, Q. Synthesis of key sandramycin analogs: Systematic examination of the intercalation chromophore Bioorganic & Medicinal Chemistry  1998 6:85-102  DOI:10.1016/s0968-0896(97)10014-1  PMID:9502108
    • Boger, D. L., Searcey, M. The first synthesis of a daphnane diterpene: the enantiocontrolled total synthesis of (+)-resiniferatoxin Chemtracts  1998 11:647-651
    • Guan, X. J., Cravatt, B. F., Ehring, C. R., Hall, J. E., Boger, D. L., Lerner, R. A., Gilula, N. B. The sleep-inducing lipid oleamide deconvolutes gap junction communication and calcium wave transmission in glial cells Journal of Cell Biology  1997 139:1785-1792  DOI:10.1083/jcb.139.7.1785  PMID:9412472  PMCID:PMC2132638
    • Boger, D. L., Loiseleur, O., Castle, S. L., Beresis, R. T., Wu, J. H. Thermal atropisomerism of fully functionalized vancomycin CD, DE, and CDE ring systems Bioorganic & Medicinal Chemistry Letters  1997 7:3199-3202  DOI:10.1016/s0960-894x(97)10182-2
    • Boger, D. L.*, Garbaccio, R. M.*, Jin, Q. Synthesis and evaluation of CC-1065 and duocarmycin analogues incorporating the iso-CI and iso-CBI alkylation subunits: impact of relocation of the C-4 carbonyl Journal of Organic Chemistry  1997 62:8875-8891  DOI:10.1021/jo971686p (* = equal contribution)
    • Eis, P. S., Smith, J. A., Rydzewski, J. M., Case, D. A., Boger, D. L., Chazin, W. J. High resolution solution structure of a DNA duplex alkylated by the antitumor agent duocarmycin SA Journal of Molecular Biology  1997 272:237-252  DOI:10.1006/jmbi.1997.1223  PMID:9299351
    • Boger, D. L.*, Haynes, N. E.*, Kitos, P. A., Warren, M. S., Ramcharan, J., Marolewski, A. E., Benkovic, S. J. 10-formyl-5,8,10-trideazafolic acid (10-formyl-TDAF): a potent inhibitor of glycinamide ribonucleotide transformylase Bioorganic & Medicinal Chemistry  1997 5:1817-1830  DOI:10.1016/s0968-0896(97)00120-x  PMID:9354237 (* = equal contribution)
    • Boger, D. L.*, Haynes, N. E.*, Warren, M. S., Ramcharan, J., Marolewski, A. E., Kitos, P. A., Benkovic, S. J. Abenzyl 10-formyl-trideazafolic acid (abenzyl 10-formyl-TDAF): an effective inhibitor of glycinamide ribonucleotide transformylase Bioorganic & Medicinal Chemistry  1997 5:1847-1852  DOI:10.1016/s0968-0896(97)00123-5  PMID:9354240 (* = equal contribution)
    • Boger, D. L.*, Haynes, N. E.*, Warren, M. S., Ramcharan, J., Kitos, P. A., Benkovic, S. J. Functionalized analogues of 5,8,10-trideazafolate: Development of an enzyme-assembled tight binding inhibitor of GAR Tfase and a potential irreversible inhibitor of AICAR Tfase Bioorganic & Medicinal Chemistry  1997 5:1839-1846  DOI:10.1016/s0968-0896(97)00122-3  PMID:9354239 (* = equal contribution)
    • Boger, D. L.*, Haynes, N. E.*, Warren, M. S., Ramcharan, J., Kitos, P. A., Benkovic, S. J. Multisubstrate analogue based on 5,8,10-trideazafolate Bioorganic & Medicinal Chemistry  1997 5:1853-1857  DOI:10.1016/s0968-0896(97)00124-7  PMID:9354241 (* = equal contribution)
    • Boger, D. L., Turnbull, P. Synthesis and evaluation of CC-1065 and duocarmycin analogs incorporating the 1,2,3,4,11,11a-hexahydrocyclopropa c naphtho 2,1-b azepin-6-one (CNA) alkylation subunit: Structural features that govern reactivity and reaction regioselectivity Journal of Organic Chemistry  1997 62:5849-5863  DOI:10.1021/jo9707085
    • Boger, D. L., Teramoto, S., Cai, H. N-methyl threonine analogues of deglycobleomycin A(2): Synthesis and evaluation Bioorganic & Medicinal Chemistry  1997 5:1577-1589  DOI:10.1016/s0968-0896(97)00107-7  PMID:9313863
    • Boger, D. L.*, Ozer, R. S.*, Andersson, C. M. Generation of targeted C-2-symmetrical compound libraries by solution-phase combinatorial chemistry Bioorganic & Medicinal Chemistry Letters  1997 7:1903-1908  DOI:10.1016/s0960-894x(97)00330-2 (* = equal contribution)
    • Boger, D. L., Borzilleri, R. M., Nukui, S., Beresis, R. T. Synthesis of the vancomycin CD and DE ring systems Journal of Organic Chemistry  1997 62:4721-4736  DOI:10.1021/jo970560p
    • Sakya, S. M., Groskopf, K. K., Boger, D. L. Preparation and inverse electron demand diels-alder reactions of 3-methoxy-6-methylthio-1,2,4,5-tetrazine Tetrahedron Letters  1997 38:3805-3808  DOI:10.1016/s0040-4039(97)00751-x
    • Boger, D. L., Hertzog, D. L., Bollinger, B., Johnson, D. S., Cai, H., Goldberg, J., Turnbull, P. Duocarmycin SA shortened, simplified, and extended agents: A systematic examination of the role of the DNA binding subunit Journal of the American Chemical Society  1997 119:4977-4986  DOI:10.1021/ja9637208
    • Boger, D. L., Bollinger, B., Hertzog, D. L., Johnson, D. S., Cai, H., Mesini, P., Garbaccio, R. M., Jin, Q., Kitos, P. A. Reversed and sandwiched analogs of duocarmycin SA: Establishment of the origin of the sequence-selective alkylation of DNA and new insights into the source of catalysis Journal of the American Chemical Society  1997 119:4987-4998  DOI:10.1021/ja9637210
    • Boger, D. L., McKie, J. A., Boyce, C. W. Asymmetric synthesis of the CBI alkylation subunit of the CC-1065 and duocarmycin analogs Synlett  1997 515-517
    • Boger, D. L.*, Boyce, C. W.*, Garbaccio, R. M., Goldberg, J. A. CC-1065 and the duocarmycins: Synthetic studies Chemical Reviews  1997 97:787-828  DOI:10.1021/cr960095g  PMID:11848889 (* = equal contribution)
    • Boger, D. L., Chen, J. H. An exceptionally potent analog of sandramycin Bioorganic & Medicinal Chemistry Letters  1997 7:919-922  DOI:10.1016/s0960-894x(97)00129-7
    • Boger, D. L.*, Zhou, J. C.*, Borzilleri, R. M., Nukui, S., Castle, S. L. Synthesis of (9R,12S)- and (9S,12S)-cycloisodityrosine and their N-methyl derivatives Journal of Organic Chemistry  1997 62:2054-2069  DOI:10.1021/jo961346o  PMID:11671510 (* = equal contribution)
    • Boger, D. L., Hikota, M., Lewis, B. M. Determination of the relative and absolute stereochemistry of fostriecin (CL-920) Journal of Organic Chemistry  1997 62:1748-1753  DOI:10.1021/jo962166h
    • Boger, D. L., Chai, W. Y., Ozer, R. S., Andersson, C. M. Solution-phase combinatorial synthesis via the olefin metathesis reaction Bioorganic & Medicinal Chemistry Letters  1997 7:463-468  DOI:10.1016/s0960-894x(97)00043-7
    • Boger, D. L., Han, N. H. CC-1065/duocarmycin and bleomycin A(2) hybrid agents: lack of enhancement of DNA alkylation by attachment to noncomplementary DNA binding subunits Bioorganic & Medicinal Chemistry  1997 5:233-243  DOI:10.1016/s0968-0896(96)00237-4  PMID:9061188
    • Boger, D. L.*, Garbaccio, R. M.* Catalysis of the CC-1065 and duocarmycin DNA alkylation reaction: DNA binding induced conformational change in the agent results in activation Bioorganic & Medicinal Chemistry  1997 5:263-276  DOI:10.1016/s0968-0896(96)00238-6  PMID:9061191 (* = equal contribution)
    • Boger, D. L.*, Boyce, C. W.*, Johnson, D. S. pH dependence of the rate of DNA alkylation for (+)-duocarmycin SA and (+)-CCBI-TMI Bioorganic & Medicinal Chemistry Letters  1997 7:233-238  DOI:10.1016/s0960-894x(96)00605-1 (* = equal contribution)
    • Boger, D. L., McKie, J. A., Nishi, T., Ogiku, T. Total synthesis of (+)-duocarmycin A, epi-(+)-duocarmycin A and their unnatural enantiomers: assessment of chemical and biological properties Journal of the American Chemical Society  1997 119:311-325  DOI:10.1021/ja962431g
    • Boger, D. L. Applications of free radicals in organic synthesis Israel Journal of Chemistry  1997 37:119-129
    • Boger, D. L.*, Haynes, N. E.*, Warren, M. S., Gooljarsingh, L. T., Ramcharan, J., Kitos, P. A., Benkovic, S. J. Functionalized analogues of 5,8,10-trideazafolate as potential inhibitors of gar tfase or aicar tfase Bioorganic & Medicinal Chemistry  1997 5:1831-1838  DOI:10.1016/s0968-0896(97)00121-1  PMID:9354238 (* = equal contribution)
    • Boger, D. L.*, Cai, H.* Solution structures of Co·Bleomycin A2 green and its complex with d(CCAGGCCTGG)​2 Chemtracts  1997 10:497-502 (* = equal contribution)
    • Cravatt, B. F., Giang, D. K., Mayfield, S. P., Boger, D. L., Lerner, R. A., Gilula, N. B. Molecular characterization of an enzyme that degrades neuromodulatory fatty-acid amides Nature  1996 384:83-87  DOI:10.1038/384083a0  PMID:8900284
    • Boger, D. L.*, Zhou, J. C.* Key analogues of the tetrapeptide subunit of RA-VII and deoxybouvardin Bioorganic & Medicinal Chemistry  1996 4:1597-1603  DOI:10.1016/0968-0896(96)00151-4  PMID:8931929 (* = equal contribution)
    • Boger, D. L., Jenkins, T. J. Synthesis, X-ray structure, and properties of fluorocyclopropane analogs of the duocarmycins incorporating the 9,9-difluoro-1,2,9,9a-tetrahydrocyclopropa c benzo e indol-4-one (F2CBI) alkylation subunit Journal of the American Chemical Society  1996 118:8860-8870  DOI:10.1021/ja961888n
    • Boger, D. L., Bollinger, B., Johnson, D. S. Examination of the role of the duocarmycin SA methoxy substituents: Identification of the minimum, fully potent DNA binding subunit Bioorganic & Medicinal Chemistry Letters  1996 6:2207-2210  DOI:10.1016/0960-894x(96)00401-5
    • Boger, D. L. Azadiene Diels-Alder reactions: scope and applications. Total synthesis of natural and ent-fredericamycin A Journal of Heterocyclic Chemistry  1996 33:1519-1531  DOI:10.1002/jhet.5570330508
    • Boger, D. L.*, Goldberg, J.*, McKie, J. A. A comparative study of the solvolysis reactivity, regioselectivity, and stereochemistry of the duocarmycin A and SA alkylation subunits Bioorganic & Medicinal Chemistry Letters  1996 6:1955-1960  DOI:10.1016/0960-894x(96)00346-0 (* = equal contribution)
    • Boger, D. L.*, Johnson, D. S.* CC-1065 and the duocarmycins: understanding their biological function through mechanistic studies Angewandte Chemie-International Edition  1996 35:1438-1474  DOI:10.1002/anie.199614381 (* = equal contribution)
    • Boger, D. L., Han, N. H., Tarby, C. M., Boyce, C. W., Cai, H., Jin, Q., Kitos, P. A. Synthesis, chemical properties, and preliminary evaluation of substituted CBI analogs of CC-1065 and the duocarmycins incorporating the 7-cyano-1,2,9,9a-tetrahydrocyclopropa c benz e indol-4-one alkylation subunit: Hammett quantitation of the magnitude of electronic effects on functional reactivity Journal of Organic Chemistry  1996 61:4894-4912  DOI:10.1021/jo9605298
    • Patterson, J. E., Ollmann, I. R., Cravatt, B. F., Boger, D. L., Wong, C. H., Lerner, R. A. Inhibition of oleamide hydrolase catalyzed hydrolysis of the endogenous sleep-inducing lipid cis-9-octadecenamide Journal of the American Chemical Society  1996 118:5938-5945  DOI:10.1021/ja954064z
    • Boger, D. L.*, Zhou, J. C.* Alternative synthesis of the cycloisodityrosine subunit of deoxybouvardin, RA-VII, and related agents: reassignment of the stereochemistry of prior intermediates Journal of Organic Chemistry  1996 61:3938-3939  DOI:10.1021/jo9604144  PMID:11667262 (* = equal contribution)
    • Boger, D. L.*, Zhou, J. C.*, Cai, H. Demonstration and definition of the noncovalent binding selectivity of agents related to CC-1065 by an affinity cleavage agent: Noncovalent binding coincidental with alkylation Bioorganic & Medicinal Chemistry  1996 4:859-867  DOI:10.1016/0968-0896(96)00073-9  PMID:8818235 (* = equal contribution)
    • Boger, D. L.*, Zhou, J. C.*, Borzilleri, R. M., Nukui, S. Synthesis of (9S,12S)-cycloisodityrosine and its unnatural (9R,12S)-diastereomer Bioorganic & Medicinal Chemistry Letters  1996 6:1089-1092  DOI:10.1016/0960-894x(96)00179-5 (* = equal contribution)
    • Boger, D. L., Borzilleri, R. M., Nukui, S. Synthesis of (r)-(4-methoxy-3,5-dihydroxyphenyl)glycine derivatives: The central amino acid of vancomycin and related agents Journal of Organic Chemistry  1996 61:3561-3565  DOI:10.1021/jo960085f
    • Cheng, S., Tarby, C. M., Comer, D. D., Williams, J. P., Caporale, L. H., Myers, P. L., Boger, D. L. A solution-phase strategy for the synthesis of chemical libraries containing small organic molecules: a universal and dipeptide mimetic template Bioorganic & Medicinal Chemistry  1996 4:727-737  DOI:10.1016/0968-0896(96)00069-7  PMID:8804539
    • Cheng, S., Comer, D. D., Williams, J. P., Myers, P. L., Boger, D. L. Novel solution phase strategy for the synthesis of chemical libraries containing small organic molecules Journal of the American Chemical Society  1996 118:2567-2573  DOI:10.1021/ja9530681
    • Boger, D. L., McKie, J. A., Han, N. H., Tarby, C. M., Riggs, H. Q. W., Kitos, P. A. A Hammett correlation for CC-1065 and duocarmycin analogs: magnitude of substituent electronic effects on functional reactivity Bioorganic & Medicinal Chemistry Letters  1996 6:659-664  DOI:10.1016/0960-894x(96)00093-5
    • Boger, D. L., McKie, J. A., Cai, H., Cacciari, B., Baraldi, P. G. Synthesis and properties of substituted CBI analogs of CC-1065 and the duocarmycins incorporating the 7-methoxy-1,2,9,9a-tetrahydrocyclopropa c benz e indol-4-one (MCBI) alkylation subunit: magnitude of electronic effects on the functional reactivity Journal of Organic Chemistry  1996 61:1710-1729  DOI:10.1021/jo952033g  PMID:11667041
    • Boger, D. L., McKie, J. A., Nishi, T., Ogiku, T. Enantioselective total synthesis of (+)-duocarmycin A, epi-(+)-duocarmycin a, and their unnatural enantiomers Journal of the American Chemical Society  1996 118:2301-2302  DOI:10.1021/ja953777e
    • Boger, D. L.*, Tarby, C. M.*, Myers, P. L., Caporale, L. H. Generalized dipeptidomimetic template: solution phase parallel synthesis of combinatorial libraries Journal of the American Chemical Society  1996 118:2109-2110  DOI:10.1021/ja9539711 (* = equal contribution)
    • Boger, D. L., Chen, J. H., Saionz, K. W. (-)-Sandramycin: total synthesis and characterization of DNA binding properties Journal of the American Chemical Society  1996 118:1629-1644  DOI:10.1021/ja952799y
    • Boger, D. L., Teramoto, S., Cai, H. Synthesis and evaluation of deglycobleomycin A(2) analogues containing a tertiary N-methyl amide and simple ester replacement for the L-histidine secondary amide: Direct functional characterization of the requirement for secondary amide metal complexation Bioorganic & Medicinal Chemistry  1996 4:179-193  DOI:10.1016/0968-0896(95)00183-2  PMID:8814877
    • Boger, D. L., Ramsey, T. M., Cai, H. Synthesis and evaluation of potential N-pi and N-sigma metal chelation sites within the beta-hydroxy-L-histidine subunit of bleomycin A(2): Functional characterization of imidazole N-pi metal complexation Bioorganic & Medicinal Chemistry  1996 4:195-207  DOI:10.1016/0968-0896(95)00184-0  PMID:8814878
    • Cravatt, B. F., Lerner, R. A., Boger, D. L. Structure determination of an endogenous sleep-inducing lipid, cis-9-octadecenamide (oleamide): A synthetic approach to the chemical analysis of trace quantities of a natural product Journal of the American Chemical Society  1996 118:580-590  DOI:10.1021/ja9532345
    • Boger, D. L. Editorial Bioorganic & Medicinal Chemistry Letters  1996 6:R3-R3  DOI:10.1016/s0960-894x(96)90241-3
    • Johnson, D. S., Boger, D. L. Control of chemoselectivity in catalytic rhodium carbenoid reactions through ligand modification. Comments Chemtracts: Inorganic Chemistry  1996 8:116-122
    • Boger, D. L. Cycloaddition reactions of azadienes, cyclopropenone ketals, and related systems: scope and applications Chemtracts: Organic Chemistry  1996 9:149-189
    • Boger, D. L., Borzilleri, R. M., Nukui, S. Synthesis of appropriately functionalized vancomycin CD and DE ring systems Bioorganic & Medicinal Chemistry Letters  1995 5:3091-3096  DOI:10.1016/0960-894x(95)00543-9
    • Boger, D. L., Takahashi, K. Total synthesis of granditropone, grandirubrine, imerubrine, and isoimerubrine Journal of the American Chemical Society  1995 117:12452-12459  DOI:10.1021/ja00155a009
    • Boger, D. L., Huter, O., Mbiya, K., Zhang, M. S. Total synthesis of natural and ent-fredericamycin-a Journal of the American Chemical Society  1995 117:11839-11849  DOI:10.1021/ja00153a004
    • Boger, D. L.*, Zhou, J. C.*, Winter, B., Kitos, P. A. Key analogs of the tetrapeptide subunit of RA-VII and deoxybouvardin Bioorganic & Medicinal Chemistry  1995 3:1579-1593  DOI:10.1016/0968-0896(95)00141-7  PMID:8770383 (* = equal contribution)
    • Boger, D. L., Mesini, P. DNA alkylation properties of CC-1065 and duocarmycin analogs incorporating the 2,3,10,10a-tetrahydrocyclopropa d benzo f quinol-5-one alkylation subunit - identification of subtle structural features that contribute to the regioselectivity of the adenine N3 alkylation reaction Journal of the American Chemical Society  1995 117:11647-11655  DOI:10.1021/ja00152a004
    • Boger, D. L., Chen, J. H. A modified friedlander condensation for the synthesis of 3-hydroxyquinoline-2-carboxylates Journal of Organic Chemistry  1995 60:7369-7371  DOI:10.1021/jo00127a055
    • Boger, D. L., Yun, W. Y., Han, N. H. 1,2,9,9a-tetrahydrocyclopropa[c]benz[e]indol-4-one (CBI) analogs of CC-1065 and the duocarmycins: synthesis and evaluation Bioorganic & Medicinal Chemistry  1995 3:1429-1453  DOI:10.1016/0968-0896(95)00130-9  PMID:8634824
    • Boger, D. L., Colletti, S. L., Teramoto, S., Ramsey, T. M., Zhou, J. C. Synthesis of key analogs of bleomycin A(2) that permit a systematic evaluation of the linker region - identification of an exceptionally prominent role for the L-threonine substituent Bioorganic & Medicinal Chemistry  1995 3:1281-1295  DOI:10.1016/0968-0896(95)00113-u  PMID:8564421
    • Boger, D. L., Teramoto, S., Zhou, J. C. Key synthetic analogs of bleomycin A(2) that directly address the effect and role of the disaccharide - demannosylbleomycin A(2) and alpha-D-mannopyranosyldeglycobleomycin A(2) Journal of the American Chemical Society  1995 117:7344-7356  DOI:10.1021/ja00133a008
    • Boger, D. L.*, Zhou, J. C.* N-desmethyl derivatives of deoxybouvardin and RA-VII: synthesis and evaluation Journal of the American Chemical Society  1995 117:7364-7378  DOI:10.1021/ja00133a010 (* = equal contribution)
    • Boger, D. L., Patane, M. A., Zhou, J. C. Solution-phase conformational studies of the cyclic peptide RA-VII: lithium-chloride perturbation of the conformational equilibria Journal of the American Chemical Society  1995 117:7357-7363  DOI:10.1021/ja00133a009
    • Boger, D. L., Teramoto, S., Honda, T., Zhou, J. C. Synthesis and evaluation of the fully functionalized bleomycin A(2) metal-binding domain-containing the 2-O-(3-O-carbamoyl-alpha-D-mannopyranosyl)-alpha-L-gulopyranosyl disaccharide Journal of the American Chemical Society  1995 117:7338-7343  DOI:10.1021/ja00133a007
    • Cravatt, B. F., Prosperogarcia, O., Siuzdak, G., Gilula, N. B., Henriksen, S. J., Boger, D. L., Lerner, R. A. Chemical characterization of a family of brain lipids that induce sleep Science  1995 268:1506-1509  DOI:10.1126/science.7770779  PMID:7770779
    • Boger, D. L., Borzilleri, R. M. An unusually facile SNAr 14-membered biaryl ether macrocyclization reaction suitable for preparation of the cycloisodityrosine subunit of bouvardin, deoxybouvardin and related agents Bioorganic & Medicinal Chemistry Letters  1995 5:1187-1190  DOI:10.1016/0960-894x(95)00192-v
    • Boger, D. L., Yun, W. Y., Cai, H., Han, N. H. CBI-CDPBO1 and CBI-CDPBI1 - CC-1065 analogs containing deep-seated modifications in the DNA-binding subunit Bioorganic & Medicinal Chemistry  1995 3:761-775  DOI:10.1016/0968-0896(95)00066-p  PMID:7582954
    • Boger, D. L., Yun, W. Y., Han, N. H., Johnson, D. S. CC-1065 CBI analogs - an example of enhancement of DNA alkylation efficiency through introduction of stabilizing electrostatic interactions Bioorganic & Medicinal Chemistry  1995 3:611-621  DOI:10.1016/0968-0896(95)00048-l  PMID:7582940
    • Boger, D. L.*, Johnson, D. S.* CC-1065 and the duocarmycins - unraveling the keys to a new class of naturally derived DNA alkylating-agents Proceedings of the National Academy of Sciences of the United States of America  1995 92:3642-3649  DOI:10.1073/pnas.92.9.3642  PMID:7731958 (* = equal contribution)
    • Boger, D. L., McKie, J. A. An efficient synthesis of 1,2,9,9a-tetrahydrocyclopropa c benz e indol-4-one (CBI) - an enhanced and simplified analog of the CC-1065 and duocarmycin alkylation subunits Journal of Organic Chemistry  1995 60:1271-1275  DOI:10.1021/jo00110a034
    • Boger, D. L.*, Johnson, D. S.* Second definitive test of proposed models for the origin of the CC-1065 and duocarmycin DNA alkylation selectivity Journal of the American Chemical Society  1995 117:1443-1444  DOI:10.1021/ja00109a035 (* = equal contribution)
    • Boger, D. L., Nishi, T. Diastereoselective dieckmann condensation suitable for introduction of the duocarmycin A C6 center - development of a divergent strategy for the total synthesis of duocarmycins A and SA Bioorganic & Medicinal Chemistry  1995 3:67-77  DOI:10.1016/0968-0896(94)00147-u  PMID:8612048
    • Boger, D. L. The duocarmycins: synthetic and mechanistic studies Accounts of Chemical Research  1995 28:20-29  DOI:10.1021/ar00049a004
    • Boger, D. L. Total synthesis of (+)- and ent-(-)-duocarmycin SA Advances in Nitrogen Heterocycles  1995 1:229-247
    • Boger, D. L., Mesini, P. Design, synthesis, and evaluation of CC-1065 and duocarmycin analogs incorporating the 2,3,10,10a-tetrahydro-1H-cyclopropa d benzo f quinol-5-one (CBQ) alkylation subunit - identification and structural origin of subtle stereoelectronic features that govern reactivity and regioselectivity Journal of the American Chemical Society  1994 116:11335-11348  DOI:10.1021/ja00104a013
    • Lerner, R. A., Siuzdak, G., Prosperogarcia, O., Henriksen, S. J., Boger, D. L., Cravatt, B. F. Cerebrodiene: A brain lipid isolated from sleep-deprived cats Proceedings of the National Academy of Sciences of the United States of America  1994 91:9505-9508  DOI:10.1073/pnas.91.20.9505  PMID:7937797  PMCID:PMC44841
    • Boger, D. L., Patane, M. A., Zhou, J. C. Total synthesis of bouvardin, O-methylbouvardin, and O-methyl-N-9-desmethylbouvardin Journal of the American Chemical Society  1994 116:8544-8556  DOI:10.1021/ja00098a015
    • Boger, D. L., Yun, W. Y. CBI-TMI - synthesis and evaluation of a key analog of the duocarmycins - validation of a direct relationship between chemical solvolytic stability and cytotoxic potency and confirmation of the structural features responsible for the distinguishing behavior of enantiomeric pairs of agents Journal of the American Chemical Society  1994 116:7996-8006  DOI:10.1021/ja00097a006
    • Boger, D. L., Kochanny, M. J. Inverse electron demand Diels-Alder reactions of heterocyclic azadienes - 4+2 -cycloaddition reaction of amidines with 1,3,5-triazines Journal of Organic Chemistry  1994 59:4950-4955  DOI:10.1021/jo00096a044
    • Boger, D. L., Nishi, T., Teegarden, B. R. P-quinonemethide analog of the CC-1065 and duocarmycin alkylation subunits Journal of Organic Chemistry  1994 59:4943-4949  DOI:10.1021/jo00096a043
    • Boger, D. L., Lerner, R. A., Cravatt, B. F. Synthesis of a functionalized rigid bicyclo[2.2.1]heptane: a useful hapten for eliciting catalytic antibodies Journal of Organic Chemistry  1994 59:5078-5079  DOI:10.1021/jo00096a064
    • Boger, D. L., Mesini, P., Tarby, C. M. Chemical and structural comparison of N-BOC-CBQ and N-BOC-CBI - identification and structural origin of an unappreciated but productive stability of the CC-1065 and duocarmycin SA alkylation subunits Journal of the American Chemical Society  1994 116:6461-6462  DOI:10.1021/ja00093a067
    • Cravatt, B. F., Ashley, J. A., Janda, K. D., Boger, D. L., Lerner, R. A. Crossing extreme mechanistic barriers by antibody catalysis: Syn elimination to a cis olefin Journal of the American Chemical Society  1994 116:6013-6014  DOI:10.1021/ja00092a080
    • Boger, D. L., Honda, T. Total synthesis of bleomycin A(2) and related agents .4. Synthesis of the disaccharide subunit - 2-O-(3-O-carbamoyl-alpha-D-mannopyranosyl)-L-gulopyranose and completion of the total synthesis of bleomycin a(2) Journal of the American Chemical Society  1994 116:5647-5656  DOI:10.1021/ja00092a014
    • Boger, D. L., Colletti, S. L., Honda, T., Menezes, R. F. Total synthesis of bleomycin-A(2) and related agents .1. Synthesis and DNA-binding properties of the extended C-terminus - tripeptide-S, tetrapeptide-S, pentapeptide-S, and related agents Journal of the American Chemical Society  1994 116:5607-5618  DOI:10.1021/ja00092a011
    • Boger, D. L., Honda, T., Dang, Q. Total synthesis of bleomycin-A(2) and related agents .2. Synthesis of (-)-pyrimidoblamic acid, epi-(+)-pyrimidoblamic acid, (+)-desacetamidopyrimidoblamic acid, and (-)-descarboxamidopyrimidoblamic acid Journal of the American Chemical Society  1994 116:5619-5630  DOI:10.1021/ja00092a012
    • Boger, D. L., Honda, T., Menezes, R. F., Colletti, S. L. Total synthesis of bleomycin-A(2) and related agents .3. Synthesis and comparative-evaluation of deglycobleomycin-A(2), epideglycobleomycin-A(2), deglycobleomycin-A(1), and desacetamidodeglycobleomycin, descarboxamidodeglycobleomycin, desmethyldeglycobleomycin, and desimidazolyldeglycobleomycin-A(2) Journal of the American Chemical Society  1994 116:5631-5646  DOI:10.1021/ja00092a013
    • Boger, D. L.*, Zhu, Y.* Diels-Alder reactions of cyclopropenone ketals - a concise tropolone annulation applicable to rubrolone-C ring introduction Journal of Organic Chemistry  1994 59:3453-3458  DOI:10.1021/jo00091a040 (* = equal contribution)
    • Boger, D. L., Yun, W. Y. Role of the CC-1065 and duocarmycin N-2 substituent - validation of a direct relationship between solvolysis chemical-stability and in-vitro biological potency Journal of the American Chemical Society  1994 116:5523-5524  DOI:10.1021/ja00091a088
    • Boger, D. L. Design, synthesis, and evaluation of DNA minor-groove binding-agents - the duocarmycins Pure and Applied Chemistry  1994 66:837-844  DOI:10.1351/pac199466040837
    • Wrasidlo, W., Johnson, D. S., Boger, D. L. Induction of endonucleolytic DNA fragmentation and apoptosis by the duocarmycins Bioorganic & Medicinal Chemistry Letters  1994 4:631-636  DOI:10.1016/s0960-894x(01)80168-2
    • Mohamadi, F., Spees, M. M., Staten, G. S., Marder, P., Kipka, J. K., Johnson, D. A., Boger, D. L., Zarrinmayeh, H. Total synthesis and biological properties of novel antineoplastic (chloromethyl)furanoindolines - an asymmetric hydroboration mediated synthesis of the alkylation subunits Journal of Medicinal Chemistry  1994 37:232-239  DOI:10.1021/jm00028a005  PMID:8295210
    • Boger, D. L., Honda, T., Menezes, R. F., Colletti, S. L., Dang, Q., Yang, W. J. Total syntheses of (+)-p-3a, epi-(-)-p-3a, and (-)-desacetamido p-3a Journal of the American Chemical Society  1994 116:82-92  DOI:10.1021/ja00080a010
    • Boger, D. L.*, Johnson, D. S.*, Yun, W. Y. (+)- and ent-(-)-duocarmycin SA and (+)- and ent-(-)-N-BOC-DSA DNA alkylation properties - alkylation site models that accommodate the offset AT-rich adenine N3 alkylation selectivity of the enantiomeric agents Journal of the American Chemical Society  1994 116:1635-1656  DOI:10.1021/ja00084a004 (* = equal contribution)
    • Johnson, D. S., Boger, D. L. Control of chemoselectivity in catalytic rhodium carbenoid reactions through ligand modification Chemtracts: Organic Chemistry  1994 7:31-37
    • Boger, D. L., Patane, M. A., Jin, Q., Kitos, P. A. Design, synthesis and evaluation of bouvardin, deoxybouvardin and RA-I-XIV pharmacophore analogs Bioorganic & Medicinal Chemistry  1994 2:85-100  DOI:10.1016/s0968-0896(00)82005-2  PMID:7922127
    • Boger, D. L.*, Johnson, D. S.*, Yun, W., Tarby, C. M. Molecular basis for sequence selective DNA alkylation by (+)- and ent-(-)-CC-1065 and related agents: alkylation site models that accommodate the offset AT-rich adenine N3 alkylation selectivity Bioorganic & Medicinal Chemistry  1994 2:115-135  DOI:10.1016/S0968-0896(00)82007-6  PMID:7922122 (* = equal contribution)
    • Boger, D. L., Chen, J. H. (-)-sandramycin - total synthesis and preliminary DNA-binding properties Journal of the American Chemical Society  1993 115:11624-11625  DOI:10.1021/ja00077a082
    • Boger, D. L., Baldino, C. M. D, l- and meso-isochrysohermidin - total synthesis and interstrand DNA cross-linking Journal of the American Chemical Society  1993 115:11418-11425  DOI:10.1021/ja00077a046
    • Boger, D. L.*, Zhou, J. C.* Total synthesis of (+)-piperazinomycin Journal of the American Chemical Society  1993 115:11426-11433  DOI:10.1021/ja00077a047 (* = equal contribution)
    • Boger, D. L., Cassidy, K. C., Nakahara, S. Total synthesis of streptonigrone Journal of the American Chemical Society  1993 115:10733-10741  DOI:10.1021/ja00076a035
    • Boger, D. L., Yun, W. Y. Reversibility of the duocarmycin-A and SA DNA alkylation reaction Journal of the American Chemical Society  1993 115:9872-9873  DOI:10.1021/ja00074a093
    • Boger, D. L., Machiya, K., Hertzog, D. L., Kitos, P. A., Holmes, D. Total synthesis and preliminary evaluation of (+)-duocarmycin and ent-(-)-duocarmycin SA Journal of the American Chemical Society  1993 115:9025-9036  DOI:10.1021/ja00073a019
    • Wasserman, H. H., Desimone, R. W., Boger, D. L., Baldino, C. M. Singlet oxygen oxidation of bipyrroles - total synthesis of d,l-isochrysohermidin and meso-isochrysohermidin Journal of the American Chemical Society  1993 115:8457-8458  DOI:10.1021/ja00071a069
    • Boger, D. L. Design, synthesis, and evaluation of DNA minor-groove binding-agents Pure and Applied Chemistry  1993 65:1123-1132  DOI:10.1351/pac199365061123
    • Boger, D. L.*, Zhou, J. C.* CDPI3-enediyne and CDPI3-EDTA conjugates - a new class of DNA cleaving agents Journal of Organic Chemistry  1993 58:3018-3024  DOI:10.1021/jo00063a019 (* = equal contribution)
    • Boger, D. L., Yohannes, D., Zhou, J. C., Patane, M. A. Total synthesis of cycloisodityrosine, RA-VII, deoxybouvardin, and N29-desmethyl-RA-VII - identification of the pharmacophore and reversal of the subunit functional roles Journal of the American Chemical Society  1993 115:3420-3430  DOI:10.1021/ja00062a004
    • Boger, D. L., Nomoto, Y., Teegarden, B. R. Vancomycin and ristocetin models - synthesis via the Ullmann macrocyclization reaction Journal of Organic Chemistry  1993 58:1425-1433  DOI:10.1021/jo00058a024
    • Boger, D. L., Honda, T. Studies on the synthesis of bleomycin-A(2) - observations on a diastereoselective imine addition-reaction for C2-acetamido side-chain introduction Tetrahedron Letters  1993 34:1567-1570  DOI:10.1016/0040-4039(93)85008-k
    • Boger, D. L., Yohannes, D. K-13 and OF4949 - evaluation of key partial structures and pharmacophore delineation Bioorganic & Medicinal Chemistry Letters  1993 3:245-250  DOI:10.1016/s0960-894x(01)80885-4
    • Boger, D. L., Corbett, W. L. 4pi participation of 1-aza-1,3-butadienes in [4 + 2] cycloaddition reactions: intramolecular Diels-Alder reactions of alpha,beta-unsaturated N-sulfonylimines Journal of Organic Chemistry  1993 58:2068-2074  DOI:10.1021/jo00060a022
    • Boger, D. L.*, Johnson, D. S.*, Palanki, M. S., Kitos, P. A., Chang, J., Dowell, P. Evaluation of functional analogs of CC-1065 and the duocarmycins incorporating the cross-linking 9a-chloromethyl-1,2,9,9a-tetrahydrocyclopropa[c]benz[e]indol-4-on e (C2BI) alkylation subunit Bioorganic & Medicinal Chemistry  1993 1:27-38  DOI:10.1016/S0968-0896(00)82100-8  PMID:8081835 (* = equal contribution)
    • Boger, D. L., Menezes, R. F., Honda, T. Total synthesis of (-)-pyrimidoblamic acid and deglycobleomycin A2 Angewandte Chemie-International Edition  1993 32:273-275  DOI:10.1002/anie.199302731
    • Boger, D. L., Machiya, K. Total synthesis of (+)-duocarmycin SA Journal of the American Chemical Society  1992 114:10056-10058  DOI:10.1021/ja00051a045
    • Boger, D. L., Yang, W. J. P-3A and (-)-desacetamido P-3A - demonstration and study of their effective functional cleavage of duplex DNA Bioorganic & Medicinal Chemistry Letters  1992 2:1649-1654  DOI:10.1016/s0960-894x(00)80449-7
    • Boger, D. L., Palanki, M. S. S. Functional analogs of CC-1065 and the duocarmycins incorporating the 9A-(chloromethyl)-1,2,9,9a-tetrahydrocyclopropa c benz e indol-4-one (C2BI) alkylation subunit - synthesis and preliminary DNA alkylation studies Journal of the American Chemical Society  1992 114:9318-9327  DOI:10.1021/ja00050a012
    • Boger, D. L., Menezes, R. F., Yang, W. J. A simple method for the purification and isolation of bleomycin-A2 Bioorganic & Medicinal Chemistry Letters  1992 2:959-962  DOI:10.1016/s0960-894x(00)80597-1
    • Boger, D. L., Corbett, W. L. A convenient and general preparation of n-sulfonylimines Journal of Organic Chemistry  1992 57:4777-4780  DOI:10.1021/jo00043a047
    • Boger, D. L., Zhang, M. S. A concise synthesis of the fredericamycin-a DEF ring-system - 4+2 cycloaddition reactions of 1-aza-1,3-butadienes Journal of Organic Chemistry  1992 57:3974-3977  DOI:10.1021/jo00040a044
    • Boger, D. L., Munk, S. A. DNA alkylation properties of enhanced functional analogs of cc-1065 incorporating the 1,2,9,9a-tetrahydrocyclopropa 1,2-c benz 1,2-e indol-4-one (cbi) alkylation subunit Journal of the American Chemical Society  1992 114:5487-5496  DOI:10.1021/ja00040a001
    • Boger, D. L., Yun, W. Y., Teegarden, B. R. An improved synthesis of 1,2,9,9a-tetrahydrocyclopropa c benz e indol-4-one (CBI) - a simplified analog of the CC-1065 alkylation subunit Journal of Organic Chemistry  1992 57:2873-2876  DOI:10.1021/jo00036a023
    • Boger, D. L., Curran, T. T. Synthesis of the lower subunit of rhizoxin Journal of Organic Chemistry  1992 57:2235-2244  DOI:10.1021/jo00034a010
    • Boger, D. L., Dang, Q. Synthesis of desacetamido P-3A: 1,3,5-triazine .fwdarw. pyrimidine heteroaromatic azadiene Diels-Alder reaction Journal of Organic Chemistry  1992 57:1631-1633  DOI:10.1021/jo00032a001
    • Boger, D. L., Mathvink, R. J. Acyl radicals - intermolecular and intramolecular alkene addition-reactions Journal of Organic Chemistry  1992 57:1429-1443  DOI:10.1021/jo00031a021
    • Boger, D. L., Yohannes, D., Myers, J. B. Synthesis of N29-desmethyl RA-VII. Identification of the pharmacophore of RA-I-VII and deoxybouvardin and reassignment of the subunit functional roles Journal of Organic Chemistry  1992 57:1319-1321  DOI:10.1021/jo00031a001
    • Boger, D. L., Sakya, S. M. CC-1065 partial structures - enhancement of noncovalent affinity for DNA minor groove binding through introduction of stabilizing electrostatic interactions Journal of Organic Chemistry  1992 57:1277-1284  DOI:10.1021/jo00030a042
    • Boger, D. L., Yun, W. Y., Terashima, S., Fukuda, Y., Nakatani, K., Kitos, P. A., Jin, Q. DNA alkylation properties of enhanced functional analogs of CC-1065 incorporating the 1,2,9,9a-tetrahydrocyclopropa[1,2-c]benz[1,2-e]indol-4-one (CBI) alkylation subunit Bioorganic & Medicinal Chemistry Letters  1992 2:759-765  DOI:10.1016/s0960-894x(00)80407-2
    • Boger, D. L., Menezes, R. F., Dang, Q., Yang, W. J. Deglyco GABA,gly-desacetamidobleomycin-A2 - a simplified synthetic model for bleomycin-A2 Bioorganic & Medicinal Chemistry Letters  1992 2:261-266  DOI:10.1016/s0960-894x(01)81076-3
    • Boger, D. L. Design, synthesis, and evaluation of functional analogs of CC-1065 and the duocarmycins: a study of structural features effecting DNA binding selectivity Advances in Heterocyclic Natural Product Synthesis  1992 2:1-188
    • Boger, D. L., Panek, J. S., Patel, M. Preparation and Diels-Alder reaction of a reactive, electron-deficient heterocyclic azadiene: dimethyl 1,2,4,5-tetrazine-3,6-dicarboxylate. 1,2-Diazine and pyrrole introduction Organic Syntheses  1992 70:79-92
    • Boger, D. L., Menezes, R. F., Dang, Q. Synthesis of desacetamidopyrimidoblamic acid and deglyco desacetamidobleomycin A2 Journal of Organic Chemistry  1992 57:4333-4336  DOI:10.1021/jo00042a004
    • Boger, D. L., Menezes, R. F. Synthesis of tri- and tetrapeptide S: the extended C-terminus of bleomycin A2 Journal of Organic Chemistry  1992 57:4331-4333  DOI:10.1021/jo00042a003
    • Boger, D. L.*, Zhu, Y.* Studies on the synthesis of rubrolone: 4π participation of O-alkyl α,β-unsaturated oximes in intramolecular [4 + 2] cycloaddition reactions Tetrahedron Letters  1991 32:7643-7646  DOI:10.1016/0040-4039(91)80554-j (* = equal contribution)
    • Boger, D. L., Baldino, C. M. Singlet oxygen mediated oxidative decarboxylation of pyrrole-2-carboxylic acids Journal of Organic Chemistry  1991 56:6942-6944  DOI:10.1021/jo00024a045
    • Boger, D. L., Myers, J. B. Design and synthesis of a conformational analog of deoxybouvardin Journal of Organic Chemistry  1991 56:5385-5390  DOI:10.1021/jo00018a035
    • Boger, D. L., Ishizaki, T., Zarrinmayeh, H. Isolation and characterization of the duocarmycin adenine DNA adduct Journal of the American Chemical Society  1991 113:6645-6649  DOI:10.1021/ja00017a042
    • Boger, D. L., Sakya, S. M., Yohannes, D. Total synthesis of combretastatin D-2 - intramolecular ullmann macrocyclization reaction Journal of Organic Chemistry  1991 56:4204-4207  DOI:10.1021/jo00013a024
    • Boger, D. L., Zhang, M. S. Total synthesis of (+/-)-cis-trikentrin-A and (+/-)-trans-trikentrin-A - Diels-Alder reactions of heteroaromatic azadienes Journal of the American Chemical Society  1991 113:4230-4234  DOI:10.1021/ja00011a026
    • Boger, D. L., Munk, S. A., Zarrinmayeh, H. (+)-CC-1065 DNA alkylation - key studies demonstrating a noncovalent binding selectivity contribution to the alkylation selectivity Journal of the American Chemical Society  1991 113:3980-3983  DOI:10.1021/ja00010a046
    • Boger, D. L., Munk, S. A., Zarrinmayeh, H., Ishizaki, T., Haught, J., Bina, M. An alternative and convenient strategy for generation of substantial quantities of singly 5-32P-end-labeled double-stranded DNA for binding-studies - development of a protocol for examination of functional features of (+)-CC-1065 and the duocarmycins that contribute to their sequence-selective DNA alkylation properties Tetrahedron  1991 47:2661-2682  DOI:10.1016/s0040-4020(01)81798-1
    • Boger, D. L. Recent advances in bioorganic chemistry. Preface Tetrahedron  1991 47:xv  DOI:10.1016/s0040-4020(01)81771-3
    • Boger, D. L., Munk, S. A., Ishizaki, T. (+)-CC-1065 DNA alkylation - observation of an unexpected relationship between cyclopropane electrophile reactivity and the intensity of DNA alkylation Journal of the American Chemical Society  1991 113:2779-2780  DOI:10.1021/ja00007a077
    • Boger, D. L., Jacobson, I. C. Synthesis and preliminary evaluation of the fredericamycin-A ABCDE ring-system Journal of Organic Chemistry  1991 56:2115-2122  DOI:10.1021/jo00006a029
    • Boger, D. L., Yohannes, D. Intramolecular Ullmann condensation reaction - an effective approach to macrocyclic diaryl ethers Journal of Organic Chemistry  1991 56:1763-1767  DOI:10.1021/jo00005a020
    • Boger, D. L., Corbett, W. L., Curran, T. T., Kasper, A. M. Inverse electron demand Diels-Alder reactions of N-sulfonyl alpha,beta-unsaturated imines - a general-approach to implementation of the 4-pi participation of 1-aza-1,3-butadienes in Diels-Alder reactions Journal of the American Chemical Society  1991 113:1713-1729  DOI:10.1021/ja00005a040
    • Boger, D. L., Yohannes, D. Total synthesis of deoxybouvardin and RA-VII - macrocyclization via an intramolecular Ullmann reaction Journal of the American Chemical Society  1991 113:1427-1429  DOI:10.1021/ja00004a062
    • Boger, D. L., Zarrinmayeh, H., Munk, S. A., Kitos, P. A., Suntornwat, O. Demonstration of a pronounced effect of noncovalent binding selectivity on the (+)-CC-1065 DNA alkylation and identification of the pharmacophore of the alkylation subunit Proceedings of the National Academy of Sciences of the United States of America  1991 88:1431-1435  DOI:10.1073/pnas.88.4.1431  PMID:1847523
    • Boger, D. L., Nakahara, S. Diels-Alder reactions of N-sulfonyl-1-aza-1,3-butadienes: Development of a synthetic approach to the streptonigrone C ring Journal of Organic Chemistry  1991 56:880-884  DOI:10.1021/jo00002a077
    • Boger, D. L., Ishizaki, T., Zarrinmayeh, H., Kitos, P. A., Suntornwat, O. A potent, simple derivative of an analog of the CC-1065 alkylation subunit Bioorganic & Medicinal Chemistry Letters  1991 1:55-58  DOI:10.1016/s0960-894x(01)81090-8
    • Boger, D. L. Duocarmycins: a new class of sequence selective DNA minor groove alkylating agents Chemtracts: Organic Chemistry  1991 4:329-349
    • Boger, D. L., Myers, J. B., Yohannes, D., Kitos, P. A., Suntornwat, O., Kitos, J. C. Evaluation of bouvardin, deoxybouvardin, and RA-I - RA-VII partial structures - reassignment of the pharmacophore Bioorganic & Medicinal Chemistry Letters  1991 1:313-316  DOI:10.1016/s0960-894x(01)80815-5
    • Boger, D. L., Zhang, M. Solution structure of FKBP, a rotamase enzyme and receptor for FK506 and rapamycin. Atomic structure of FKBP-FK506, an immunophilin-immunosuppressant complex Chemtracts: Organic Chemistry  1991 4:272-278
    • Boger, D. L., Ishizaki, T., Sakya, S. M., Munk, S. A., Kitos, P. A., Jin, Q., Besterman, J. M. Synthesis and preliminary evaluation of (+)-CBI-indole2 - an enhanced functional analog of (+)-CC-1065 Bioorganic & Medicinal Chemistry Letters  1991 1:115-120  DOI:10.1016/s0960-894x(00)80243-7
    • Cable, M. P., Coleman, R. S., Danishefsky, S. J., Boger, D. L., Sakya, S. M. Total synthesis of calicheamicinone: a solution to the problem of the elusive urethane Chemtracts: Organic Chemistry  1991 4:129-134
    • Boger, D. L., Yohannes, D. Total synthesis of L,L-isodityrosine and isodityrosine-derived agents - K-13, OF4949-III, and OF4949-IV Journal of Organic Chemistry  1990 55:6000-6017  DOI:10.1021/jo00311a019
    • Boger, D. L., Ishizaki, T., Zarrinmayeh, H., Munk, S. A., Kitos, P. A., Suntornwat, O. Duocarmycin pyrindamycin DNA alkylation properties and identification, synthesis, and evaluation of agents incorporating the pharmacophore of the duocarmycin pyrindamycin alkylation subunit - identification of the CC-1065-duocarmycin common pharmacophore Journal of the American Chemical Society  1990 112:8961-8971  DOI:10.1021/ja00180a048
    • Boger, D. L., Ishizaki, T., Kitos, P. A., Suntornwat, O. Synthesis of N-(tert-butyloxycarbonyl)-CBI, CBI, CBI-CBI1, and CBI-CDPI2 - enhanced functional analogs of CC-1065 incorporating the 1,2,9,9a-tetrahydrocyclopropa c benz e indol-4-one (CBI) left-hand subunit Journal of Organic Chemistry  1990 55:5823-5832  DOI:10.1021/jo00310a013
    • Boger, D. L., Curran, T. T. Diels-Alder reactions of 1-aza-1,3-butadienes: room temperature, endo-selective LUMOdiene-controlled [4 + 2] cycloaddition reactions of N-sulfonyl-4-(ethoxycarbonyl)-1-aza-1,3-butadienes Journal of Organic Chemistry  1990 55:5439-5442  DOI:10.1021/jo00307a009
    • Boger, D. L., Mathvink, R. J. Tandem free-radical ring expansion and 5-exo-dig 5-hexynyl radical cyclization: a useful approach to fused bicyclic carbocycles Journal of Organic Chemistry  1990 55:5442-5444  DOI:10.1021/jo00307a010
    • Boger, D. L. Diels-Alder reactions of azadienes: scope and applications Bulletin des Societes Chimiques Belges  1990 99:599-615  DOI:10.1002/bscb.19900990902
    • Boger, D. L., Ishizaki, T., Zarrinmayeh, H., Kitos, P. A., Suntornwat, O. Synthesis and preliminary evaluation of agents incorporating the pharmacophore of the duocarmycin pyrindamycin alkylation subunit - identification of the cc-1065 duocarmycin common pharmacophore Journal of Organic Chemistry  1990 55:4499-4502  DOI:10.1021/jo00302a002
    • Boger, D. L., Ishizaki, T., Zarrinmayeh, H., Kitos, P. A., Suntornwat, O. Synthesis and preliminary evaluation of agents incorporating the pharmacophore of the duocarmycin/pyrindamycin alkylation subunit: identification of the CC-1065/duocarmycin common pharmacophore Journal of Organic Chemistry  1990 55:4499-4502  DOI:10.1021/jo00302a002
    • Boger, D. L., Wysocki, R. J., Ishizaki, T. Synthesis of n-(phenylsulfonyl)-CI, N-((tert-butyloxy)carbonyl)-CI, CI-CDPI1, and CI-CDPI2 - CC-1065 functional analogs incorporating the parent 1,2,7,7a-tetrahydrocycloprop 1,2-c indol-4-one (CI) left-hand subunit Journal of the American Chemical Society  1990 112:5230-5240  DOI:10.1021/ja00169a034
    • Boger, D. L., Corbett, W. L., Wiggins, J. M. Room-temperature, endo-specific 1-aza-1,3-butadiene Diels-Alder reactions: acceleration of the LUMOdiene-controlled [4 + 2] cycloaddition reactions through noncomplementary aza diene substitution Journal of Organic Chemistry  1990 55:2999-3000  DOI:10.1021/jo00297a006
    • Boger, D. L., Mathvink, R. J. Intramolecular acyl radical alkene addition-reactions - macrocyclization reactions Journal of the American Chemical Society  1990 112:4008-4011  DOI:10.1021/ja00166a044
    • Boger, D. L., Mathvink, R. J. Tandem free-radical alkene addition-reactions of acyl radicals Journal of the American Chemical Society  1990 112:4003-4008  DOI:10.1021/ja00166a043
    • Boger, D. L., Jacobson, I. C. Studies of the total synthesis of fredericamycin-A - preparation of key partial structures and development of an intermolecular alkyne chromium carbene complex benzannulation cyclization approach to the ABCD(E) ring-system Journal of Organic Chemistry  1990 55:1919-1928  DOI:10.1021/jo00293a043
    • Boger, D. L., Zarrinmayeh, H. Regiocontrolled nucleophilic-addition to selectively activated para-quinone diimines - alternative preparation of a key intermediate employed in the preparation of the CC-1065 left-hand subunit Journal of Organic Chemistry  1990 55:1379-1390  DOI:10.1021/jo00291a059
    • Boger, D. L., Invergo, B. J., Coleman, R. S., Zarrinmayeh, H., Kitos, P. A., Thompson, S. C., Leong, T., McLaughlin, L. W. A demonstration of the intrinsic importance of stabilizing hydrophobic binding and noncovalent van der Waals contacts dominant in the noncovalent CC-1065/b-DNA binding Chemico-Biological Interactions  1990 73:29-52  DOI:10.1016/0009-2797(90)90107-x  PMID:2406033
    • Boger, D. L., Yohannes, D. Design and total synthesis of a conformational analog of bouvardin deoxybouvardin Synlett  1990 33-36
    • Boger, D. L., Yohannes, D. Photolytic reactions of chromium aminocarbene complexes. Conversion of amides to α-amino acids Chemtracts: Organic Chemistry  1990 3:323-326
    • Boger, D. L. Polyethylene-bound soluble recoverable palladium(0) catalysts Chemtracts: Organic Chemistry  1990 3:85-87
    • Boger, D. L., Ishizaki, T. Resolution of a CBI precursor and incorporation into the synthesis of (+)-CBI, (+)-CBI-CDPI1, (+)-CBI-CDPI2 - enhanced functional analogs of (+)-CC-1065 - a critical-appraisal of a proposed relationship between electrophile reactivity, DNA-binding properties, and cytotoxic potency Tetrahedron Letters  1990 31:793-796  DOI:10.1016/s0040-4039(00)94629-x
    • Boger, D. L., Coleman, R. S., Invergo, B. J., Sakya, S. M., Ishizaki, T., Munk, S. A., Zarrinmayeh, H., Kitos, P. A., Thompson, S. C. Synthesis and evaluation of aborted and extended CC-1065 functional analogs - (+)-CPI-PDE-1, and (-)-CPI-PDE-1, (+)-CPI-PDE-1, and (-)-CPI-CDPI1, and (+/-)-CPI-PDE-i1, (+)-CPI-PDE-i1, and (-)-CPI-CDPI3 - preparation of key partial structures and definition of an additional functional-role of the CC-1065 central and right-hand subunits Journal of the American Chemical Society  1990 112:4623-4632  DOI:10.1021/ja00168a002
    • Boger, D. L. The absolute configuration and synthesis of natural (-)-dolastatin 10 Chemtracts: Organic Chemistry  1990 3:54-57
    • Boger, D. L. Use of methylenecyclopropanone ketals for cyclopentane synthesis. A new efficient thermal [3 + 2] cycloaddition Chemtracts: Organic Chemistry  1990 3:47-50
    • Boger, D. L., Ishizaki, T., Wysocki, R. J., Munk, S. A., Kitos, P. A., Suntornwat, O. Total synthesis and evaluation of (+/-)-N-(tert-butyloxycarbonyl)-CBI, (+/-)-CBI-CDPI1, and (+/-)-CBI-CDPI2 - CC-1065 functional agents incorporating the equivalent 1,2,9,9a-tetrahydrocycloprop 1,2-c benz 1,2-e indol-4-one (CBI) left-hand subunit Journal of the American Chemical Society  1989 111:6461-6463  DOI:10.1021/ja00198a089
    • Boger, D. L., Yohannes, D. Total synthesis of K-13 Journal of Organic Chemistry  1989 54:2498-2502  DOI:10.1021/jo00272a003
    • Boger, D. L., Wysocki, R. J. Total synthesis of (.+-.)-N-(phenylsulfonyl)- and (.+-.)-N-(tert-butyloxycarbonyl)-CI, (.+-.)-CI-CDPI1, and (.+-.)-CI-CDPI2: CC-1065 functional analogs incorporating the parent 1,2,7,7a-tetrahydrocycloprop[1,2-c]indol-4-one (CI) left-hand subunit Journal of Organic Chemistry  1989 54:1238-1240  DOI:10.1021/jo00267a004
    • Boger, D. L., Kasper, A. M. A general-solution to implementing the 4-p participation of 1-aza-1,3-butadienes in Diels-Alder reactions - inverse electron demand Diels-Alder reactions of alpha,beta-unsaturated n-benzenesulfonyl imines Journal of the American Chemical Society  1989 111:1517-1519  DOI:10.1021/ja00186a067
    • Boger, D. L., Wysocki, R. J. A study of the scope of the 4+2 cyclo-addition reactions of unactivated 1,3-oxazin-6-ones Journal of Organic Chemistry  1989 54:714-718  DOI:10.1021/jo00264a041
    • Boger, D. L. Diels-Alder reactions of heterocyclic azadienes: development of a strategy for the total synthesis of streptonigrin, lavendamycin, and synthetic quinoline-5,8-quinones Strategies and Tactics in Organic Synthesis  1989 2:1-56  DOI:10.1016/B978-0-08-092429-8.50006-4
    • Boger, D. L., Mathvink, R. J. Phenylselenoesters as effective precursors of acyl radicals for use in intermolecular alkene addition reactions Journal of Organic Chemistry  1989 54:1777-1779  DOI:10.1021/jo00269a001
    • Boger, D. L., Patel, M. Recent applications of the inverse electron demand Diels-Alder reaction Progress in Heterocyclic Chemistry  1989 1:30-64
    • Boger, D. L., Jacobson, I. C. Studies on the total synthesis of fredericamycin-a - development of an intermolecular alkyne-chromium carbene complex cyclization approach to the abcde ring-system Tetrahedron Letters  1989 30:2037-2040  DOI:10.1016/s0040-4039(01)93705-0
    • Boger, D. L., Yohannes, D. Synthesis of isodityrosine Tetrahedron Letters  1989 30:2053-2056  DOI:10.1016/s0040-4039(01)93709-8
    • Boger, D. L., Yohannes, D. Total synthesis of OF4949-III and OF4949-IV - unusual effects of remote substituents on the rate of macrocyclization reactions Tetrahedron Letters  1989 30:5061-5064  DOI:10.1016/s0040-4039(01)93447-1
    • Boger, D. L., Cerbone, L. R., Yohannes, D. Oxidative coupling of methyl 6-hydroxyindole-2-carboxylate with primary amines - preparation of 2-substituted methyl pyrrolo 2,3-e benzoxazole-5-carboxylates Journal of Organic Chemistry  1988 53:5163-5166  DOI:10.1021/jo00256a053
    • Boger, D. L., Wysocki, R. J. Thermal cyclo-addition reactions of pi-delocalized singlet vinylcarbenes - 3-carbon 1,1-dipoles/1,3-dipoles - the thermal 3-carbon + 2-carbon cyclo-addition Journal of Organic Chemistry  1988 53:3408-3421  DOI:10.1021/jo00250a002
    • Boger, D. L., Mathvink, R. J. Acyl radicals: functionalized free radicals for intramolecular cyclization reactions Journal of Organic Chemistry  1988 53:3377-3379  DOI:10.1021/jo00249a053
    • Boger, D. L., Coleman, R. S. Total synthesis of (+/-)-n-2-(phenylsulfonyl)-cpi, (+/-)-cc-1065, (+)-cc-1065, ent-(-)-cc-1065, and the precise, functional agents (+/-)-cpi-cdpi2, (+)-cpi-cdpi2, and (-)-cpi-cdpi2 (+/-)-(3br-star,4as-star)-deoxy-cc-1065, (+)-(3br,4as)-deoxy-cc-1065, and (-)-(3bs,4ar)-deoxy-cc-1065 Journal of the American Chemical Society  1988 110:4796-4807  DOI:10.1021/ja00222a043
    • Boger, D. L., Sakya, S. M. Inverse electron demand Diels-Alder reactions of 3,6-bis(methylthio)-1,2,4,5-tetrazine - 1,2-diazine introduction and direct implementation of a divergent 1,2,4,5-tetrazine- 1,2-diazine- benzene (indoline indole) Diels-Alder strategy Journal of Organic Chemistry  1988 53:1415-1423  DOI:10.1021/jo00242a014
    • Boger, D. L., Patel, M. Total synthesis of prodigiosin, prodigiosene, and desmethoxyprodigiosin - Diels-Alder reactions of heterocyclic azadienes and development of an effective palladium(II)-promoted 2,2'-bipyrrole coupling procedure Journal of Organic Chemistry  1988 53:1405-1415  DOI:10.1021/jo00242a013
    • Boger, D. L., Yohannes, D. Studies on the total synthesis of bouvardin and deoxybouvardin - cyclic hexapeptide cyclization studies and preparation of key partial structures Journal of Organic Chemistry  1988 53:487-499  DOI:10.1021/jo00238a005
    • Boger, D. L., Coleman, R. S. Total synthesis of (+)CPI-CDPI2 and (-)-CPI-CDPI2 - (+)-(3br,4as)-deoxy-CC-1065 and (-)-(3bs,4ar)-deoxy-CC-1065 Journal of Organic Chemistry  1988 53:695-698  DOI:10.1021/jo00238a042
    • Boger, D. L., Robarge, K. D. A divergent de novo synthesis of carbohydrates based on an accelerated inverse electron demand Diels-Alder reaction of 1-oxa-1,3-butadienes Journal of Organic Chemistry  1988 53:5793-5796  DOI:10.1021/jo00259a040
    • Boger, D. L., Robarge, K. D. Accelerated inverse electron demand Diels-Alder reactions of 1-oxa-1,3-butadienes: [4 + 2] cycloaddition reactions of beta,gamma-unsaturated alpha-keto esters Journal of Organic Chemistry  1988 53:3373-3377  DOI:10.1021/jo00249a052
    • Boger, D. L., Dang, Q. Inverse electron demand Diels-Alder reactions of 2,4,6-tris(ethoxycarbonyl)-1,3,5-triazine and 2,4,6-tris(methylthio)-1,3,5-triazine - pyrimidine introduction Tetrahedron  1988 44:3379-3390  DOI:10.1016/s0040-4020(01)85973-1
    • Boger, D. L., Panek, J. S., Yasuda, M. Preparation and inverse electron demand Diels-Alder reaction of an electron-deficient heterocyclic azadiene - triethyl 1,2,4-triazine-3,5,6-tricarboxylate Organic Syntheses  1988 66:142-149
    • Boger, D. L., Panek, J. S., Yasuda, M. Preparation and inverse-​electron-​demand Diels-​Alder reaction of an electron-​deficient heterocyclic azadiene: triethyl 1,​2,​4-​triazine-​3,​5,​6-​tricarboxylate and 2,​3,​6-​tricarboethoxypyridine Organic Syntheses  1988 66:142-149
    • Boger, D. L., Coleman, R. S. Total synthesis of (+)-CC-1065 and ent-(-)-CC-1065 Journal of the American Chemical Society  1988 110:1321-1323  DOI:10.1021/ja00212a067
    • Boger, D. L., Yohannes, D. Selectively protected L-dopa derivatives - application of the benzylic hydroperoxide rearrangement Journal of Organic Chemistry  1987 52:5283-5286  DOI:10.1021/jo00232a044
    • Boger, D. L., Yasuda, M., Mitscher, L. A., Drake, S. D., Kitos, P. A., Thompson, S. C. Streptonigrin and lavendamycin partial structures - probes for the minimum, potent pharmacophore of streptonigrin, lavendamycin, and synthetic quinoline-5,8-diones Journal of Medicinal Chemistry  1987 30:1918-1928  DOI:10.1021/jm00393a040  PMID:3656364
    • Yasuda, M., Boger, D. L. Streptonigrin and lavendamycin partial structures. Preparation of 7-amino-2-(2′-pyridyl)quinoline-5,8-quinone-6′-carboxylic acid: a probe for the minimum, potent pharmacophore of the naturally occurring antitumor-antibiotics Journal of Heterocyclic Chemistry  1987 24:1253-1260  DOI:10.1002/jhet.5570240504
    • Boger, D. L., Patel, M. Indole N-carbonyl compounds - preparation and coupling of indole-1-carboxylic acid anhydride Journal of Organic Chemistry  1987 52:3934-3936  DOI:10.1021/jo00226a044
    • Boger, D. L., Patel, M. Activation and coupling of pyrrole-1-carboxylic acid in the formation of pyrrole N-carbonyl compounds - pyrrole-1-carboxylic acid anhydride Journal of Organic Chemistry  1987 52:2319-2323  DOI:10.1021/jo00387a046
    • Boger, D. L., Coleman, R. S. Diels-alder reactions of heterocyclic azadienes - total synthesis of pde-i, pde-ii, and pde-i dimer methyl-ester Journal of the American Chemical Society  1987 109:2717-2727  DOI:10.1021/ja00243a027
    • Boger, D. L., Coleman, R. S., Invergo, B. J. Studies on the total synthesis of CC-1065 - preparation of a synthetic, simplified 3-carbamoyl-1,2-dihydro-3h-pyrrolo 3,2-e indole dimer/trimer/tetramer (CDPI dimer/trimer/tetramer) and development of methodology for PDE-I dimer methyl-ester formation Journal of Organic Chemistry  1987 52:1521-1530  DOI:10.1021/jo00384a026
    • Boger, D. L., Coleman, R. S. Further observations on the Lewis acid-catalyzed benzylic hydroperoxide rearrangement - use of a boron-trifluoride hydrogen-peroxide preformed, aged reagent Tetrahedron Letters  1987 28:1027-1030  DOI:10.1016/s0040-4039(00)95902-1
    • Boger, D. L., Mullican, M. D. Preparation and inverse electron demand Diels-Alder reaction of an electron-deficient diene: methyl 2-oxo-5,6,7,8-tetrahydro-2H-1-benzopyran-3-carboxylate (2H-1-benzopyran-3-carboxylic acid, 5,6,7,8-tetrahydro-2-oxo-, methyl ester) Organic Syntheses  1987 65:98-107
    • Boger, D. L., Brotherton, C. E., Georg, G. I. Preparation and three-carbon + two-carbon cycloaddition of a cyclopropenone ketal: cyclopropenone 1,3-propanediol ketal (4,8-dioxaspiro[2.5]oct-1-ene) Organic Syntheses  1987 65:32-41
    • Boger, D. L., Patel, M. Total synthesis of prodigiosin Tetrahedron Letters  1987 28:2499-2502  DOI:10.1016/s0040-4039(00)95451-0
    • Boger, D. L., Coleman, R. S. Benzylic hydroperoxide rearrangement - observations on a viable and convenient alternative to the Baeyer Villiger rearrangement Journal of Organic Chemistry  1986 51:5436-5439  DOI:10.1021/jo00376a079
    • Boger, D. L., Brotherton, C. E. Thermal-reactions of cyclopropenone ketals - application of the cycloaddition reactions of delocalized singlet vinylcarbenes - 3-carbon 1,1-dipoles 1,3-dipoles - an alternative synthesis of deacetamidocolchiceine - formal total synthesis of colchicine Journal of the American Chemical Society  1986 108:6713-6719  DOI:10.1021/ja00281a042
    • Boger, D. L., Brotherton, C. E. Thermal-reactions of cyclopropenone ketals - key mechanistic features and scope of the cycloaddition reactions of delocalized singlet vinylcarbenes - 3-carbon 1,1-dipoles 1,3-dipoles Journal of the American Chemical Society  1986 108:6695-6713  DOI:10.1021/ja00281a041
    • Boger, D. L. Diels-Alder reactions of heterocyclic azadienes: scope and applications Chemical Reviews  1986 86:781-793  DOI:10.1021/cr00075a004
    • Boger, D. L., Coleman, R. S. Diels-Alder reactions of heterocyclic azadienes: total synthesis of PDE-II methyl ester Journal of Organic Chemistry  1986 51:3250-3252  DOI:10.1021/jo00366a048
    • Boger, D. L., Yasuda, M. An improved and divergent introduction of the streptonigrin and lavendamycin quinoline-5,8-quinone AB ring-systems Heterocycles  1986 24:1067-1073  DOI:10.3987/R-1986-04-1067
    • Boger, D. L., Brotherton, C. E. Diels-Alder cycloaddition reactions of cyclopropenone ketals: dual participation in inverse electron demand (LUMOdiene controlled) and normal HOMOdiene controlled) Diels-Alder reactions, approaches to the preparation of tropones Tetrahedron  1986 42:2777-2785  DOI:10.1016/s0040-4020(01)90567-8
    • Boger, D. L., Patel, M. Diels-Alder cycloadditions of rigid dienophiles: a probe for allylic axial substituent control of the pi-facial selectivity in the Diels-Alder reaction Tetrahedron Letters  1986 27:683-686  DOI:10.1016/s0040-4039(00)84072-1
    • Boger, D. L., Duff, S. R., Panek, J. S., Yasuda, M. Inverse electron demand Diels-Alder reactions of heterocyclic aza dienes - studies on the total synthesis of lavendamycin - investigative studies on the preparation of the CDE beta-carboline ring-system and AB quinoline-5,8-quinone ring-system Journal of Organic Chemistry  1985 50:5782-5789  DOI:10.1021/jo00350a069
    • Boger, D. L., Duff, S. R., Panek, J. S., Yasuda, M. Total synthesis of lavendamycin methyl-ester Journal of Organic Chemistry  1985 50:5790-5795  DOI:10.1021/jo00350a070
    • Boger, D. L., Coleman, R. S., Panek, J. S., Huber, F. X. A detailed, convenient preparation of dimethyl "1,2,4,5-tetrazine-3,6-dicarboxylate Journal of Organic Chemistry  1985 50:5377-5379  DOI:10.1021/jo00225a076
    • Boger, D. L., Mitscher, L. A., Mullican, M. D., Drake, S. D., Kitos, P. Antimicrobial and cytotoxic properties of 9,10-dihydrophenanthrenes: structure activity studies on juncusol Journal of Medicinal Chemistry  1985 28:1543-1547  DOI:10.1021/jm00148a031  PMID:4045930
    • Boger, D. L., Panek, J. S. Inverse electron demand Diels-Alder reactions of heterocyclic azadienes - formal total synthesis of streptonigrin Journal of the American Chemical Society  1985 107:5745-5754  DOI:10.1021/ja00306a024
    • Boger, D. L., Mullican, M. D., Hellberg, M. R., Patel, M. Preparation of optically-active, functionalized cis-delta-6-1-octalones Journal of Organic Chemistry  1985 50:1904-1911  DOI:10.1021/jo00211a024
    • Boger, D. L., Patel, M., Takusagawa, F. Regioselectivity of the intermolecular Diels-Alder reaction of acyl nitroso-compounds (C-nitrosocarbonyl compounds) and nitrosoformates (O-nitrosocarbonyl compounds) - preparation of functionalized cis-delta-6-1-octalones Journal of Organic Chemistry  1985 50:1911-1916  DOI:10.1021/jo00211a025
    • Boger, D. L., Brotherton, C. E. Thermal, four-carbon + three-carbon cycloaddition reaction of cyclopropenone ketals. Total synthesis of deacetamidocolchiceine: formal total synthesis of colchicine Journal of Organic Chemistry  1985 50:3425-3427  DOI:10.1021/jo00218a042
    • Boger, D. L., Brotherton, C. E., Panek, J. S., Yohannes, D. Direct introduction of nitriles via use of unstable reissert intermediates - convenient procedures for the preparation of 2-cyanoquinolines and 1-cyanoisoquinolines Journal of Organic Chemistry  1984 49:4056-4058  DOI:10.1021/jo00195a036
    • Boger, D. L., Brotherton, C. E. Effective, thermal 3-carbon + 2-carbon cycloaddition for cyclopentenone formation - formal 1,3-dipolar cycloaddition of cyclopropenone ketals Journal of the American Chemical Society  1984 106:805-807  DOI:10.1021/ja00315a065
    • Boger, D. L., Brotherton, C. E. Effective, thermal one-carbon + 2-carbon cycloaddition of cyclopropenone ketals with electron deficient olefins - cyclopropane formation Tetrahedron Letters  1984 25:5611-5614  DOI:10.1016/s0040-4039(01)91393-0
    • Boger, D. L., Coleman, R. S. Intramolecular diels-alder reactions of 1,2-diazines - general indoline synthesis - studies on the preparation of the central and right-hand segments of cc-1065 Journal of Organic Chemistry  1984 49:2240-2245  DOI:10.1021/jo00186a032
    • Boger, D. L., Mullican, M. D. Inverse electron demand Diels-Alder reactions of 3-carbomethoxy-2-pyrones - controlled introduction of oxygenated aromatics - benzene, phenol, catechol, resorcinol, and pyrogallol annulation - regiospecific total synthesis of sendaverine and a preparation of 6,7-benzomorphans Journal of Organic Chemistry  1984 49:4033-4044  DOI:10.1021/jo00195a033
    • Boger, D. L., Panek, J. S. Palladium (0) mediated beta-carboline synthesis - preparation of the CDE ring-system of lavendamycin Tetrahedron Letters  1984 25:3175-3178
    • Boger, D. L., Patel, M. Regioselectivity in the intermolecular Diels-Alder reaction of acyl nitroso compounds (C-nitrosocarbonyl compounds) and nitrosoformates (O-nitrosocarbonyl compounds) Journal of Organic Chemistry  1984 49:4098-4099  DOI:10.1021/jo00195a057
    • Boger, D. L., Mullican, M. D. Regiospecific total synthesis of juncusol Journal of Organic Chemistry  1984 49:4045-4050  DOI:10.1021/jo00195a034
    • Boger, D. L., Coleman, R. S., Panek, J. S., Yohannes, D. Thermal cycloaddition of dimethyl "1,2,4,5-tetrazine-3,6-dicarboxylate with electron-rich olefins - 1,2-diazine and pyrrole introduction - preparation of octamethylporphin (OMP) Journal of Organic Chemistry  1984 49:4405-4409  DOI:10.1021/jo00197a015
    • Boger, D. L., Brotherton, C. E., Georg, G. I. Thermal, 3-carbon + 2-atom cycloaddition of cyclopropenone ketals with carbon-heteroatom double-bonds - butenolide, furan, and gamma-keto ester preparation Tetrahedron Letters  1984 25:5615-5618  DOI:10.1016/s0040-4039(01)91394-2
    • Boger, D. L., Brotherton, C. E. Total syntheses of azafluoranthene alkaloids: rufescine and imeluteine Journal of Organic Chemistry  1984 49:4050-4055  DOI:10.1021/jo00195a035
    • Boger, D. L., Panek, J. S. 1,2,4-triazine preparation via thermal cycloaddition of dimethyl 1,2,4,5-tetrazine-3,6-dicarboxylate with aryl thioimidates Tetrahedron Letters  1983 24:4511-4514  DOI:10.1016/s0040-4039(00)85941-9
    • Boger, D. L. Diels-Alder reactions of azadienes Tetrahedron  1983 39:2869-2939  DOI:10.1016/s0040-4020(01)92154-4
    • Boger, D. L., Panek, J. S. Formal total synthesis of streptonigrin Journal of Organic Chemistry  1983 48:621-623  DOI:10.1021/jo00152a049
    • Boger, D. L., Mullican, M. D. Inverse electron demand Diels-Alder reactions of 3-carbomethoxy-2-pyrones - controlled introduction of oxygenated aromatics - benzene, phenol, catechol, resorcinol, pyrogallol annulation Tetrahedron Letters  1983 24:4939-4942  DOI:10.1016/s0040-4039(01)99816-8
    • Boger, D. L., Panek, J. S., Meier, M. M. Diels-Alder reaction of heterocyclic azadienes. 2. Catalytic Diels-Alder reaction of in situ generated enamines with 1,2,4-triazines: general pyridine annulation Journal of Organic Chemistry  1982 47:895-897  DOI:10.1021/jo00344a031
    • Boger, D. L., Mullican, M. D. Inverse electron demand diels-alder reaction of 3-carbomethoxy-2-pyrones with 1,1-dimethoxyethylene - a simple and mild method of aryl annulation Tetrahedron Letters  1982 23:4551-4554  DOI:10.1016/s0040-4039(00)85651-8
    • Boger, D. L., Panek, J. S. Pyridine construction via thermal cycloaddition of 1,2,4-triazines with enamines - studies on the preparation of the bi-aryl CD rings of streptonigrin Journal of Organic Chemistry  1982 47:3763-3765  DOI:10.1021/jo00140a035
    • Boger, D. L., Mullican, M. D. Regiospecific total synthesis of juncusol Tetrahedron Letters  1982 23:4555-4558  DOI:10.1016/s0040-4039(00)85652-x
    • Boger, D. L., Patel, M., Mullican, M. D. Synthetic analgesics - preparation of racemic 6,7-benzomorphans Tetrahedron Letters  1982 23:4559-4562  DOI:10.1016/s0040-4039(00)85653-1
    • Boger, D. L., Schumacher, J., Mullican, M. D., Patel, M., Panek, J. S. Thermal cycloaddition of 1,3,5-triazine with enamines - regiospecific pyrimidine annulation Journal of Organic Chemistry  1982 47:2673-2675  DOI:10.1021/jo00134a034
    • Boger, D. L., Brotherton, C. E., Kelley, M. D. A simplified isoquinoline synthesis Tetrahedron  1981 37:3977-3980  DOI:10.1016/s0040-4020(01)93272-7
    • Boger, D. L., Panek, J. S. Diels-alder reaction of heterocyclic azadienes .1. Thermal cycloaddition of 1,2,4-triazine with enamines - simple preparation of substituted pyridines Journal of Organic Chemistry  1981 46:2179-2182  DOI:10.1021/jo00323a044
    • Boger, D. L., Panek, J. S. Preparation of (R)-(+) and (S)-(-)-4-iodo-1,2-epoxybutane (R)-(2-iodoethyl)oxirane and (S)-(2-iodoethyl)oxirane , useful chiral synthons Journal of Organic Chemistry  1981 46:1208-1210  DOI:10.1021/jo00319a034
    • Boger, D. L., Brotherton, C. E. Preparation of 3-methyl-4-vinyl-1,2,5-oxadiazole and 3-methyl-4-vinyl-1,2,5-thiadiazole Journal of Heterocyclic Chemistry  1981 18:1247-1249  DOI:10.1002/jhet.5570180636
    • Boger, D. L., Mullican, M. D. A simple and convenient phenol annelation Journal of Organic Chemistry  1980 45:5002-5004  DOI:10.1021/jo01312a044
    • Corey, E. J., Boger, D. L. Application of benzothiazoles to carbon-carbon bond formation in organic-synthesis Tetrahedron Letters  1978 9-12
    • Corey, E. J., Boger, D. L. Benzothiazoles as carbonyl equivalents Tetrahedron Letters  1978 5-8
    • Boger, D. L. Concerning the stereochemistry of 9-methyl-Δ1-3-octalone Tetrahedron Letters  1978 17-18  DOI:10.1016/S0040-4039(01)88970-X
    • Boger, D. L. Convenient preparation of 2-substituted benzothiazoles Journal of Organic Chemistry  1978 43:2296-2297  DOI:10.1021/jo00405a050
    • Corey, E. J., Boger, D. L. New and unusually flexible scheme for annulation to form fused cyclohexenone units Tetrahedron Letters  1978 4597-4600  DOI:10.1016/S0040-4039(01)85680-X
    • Corey, E. J., Boger, D. L. New annulation processes for fused and spiro rings based on chemistry of benzothiazoles Tetrahedron Letters  1978 13-16
    • Corey, E. J., Boger, D. L. Oxidative cationic cyclization reactions effected by pyridinium chlorochromate Tetrahedron Letters  1978 2461-2464  DOI:10.1016/S0040-4039(01)94800-2
    • Burgstahler, A. W., Boger, D. L., Naik, N. C. Synthesis and chiroptical properties of some asymmetric planar cisoid dienes Tetrahedron  1976 32:309-315  DOI:10.1016/0040-4020(76)80042-7
  • report

    • Dreyton, C. J., Jones, J. E., Knuckley, B. A., Subramanian, V., Anderson, E. D., Brown, S. J., Fernandez-Vega, V., Eberhart, C., Spicer, T., Zuhl, A. M., Ferguson, J., Speers, A. E., et al. Optimization and characterization of a pan protein arginine deiminase (PAD) inhibitor Probe Reports from the NIH Molecular Libraries Program. 2010  PMID:23833800
  • thesis

    • I. New annulation processes ; II. Studies directed toward a biomimetic syntheic approach to prostaglandins 1980

featured in

  • Dale Boger Appointed as Chair of Department of Chemistry; Thomas Kodadek, Vice Chair  Newsletter
  • Perspective articles on the utility and application of solution-phase combinatorial chemistry  Academic Article
  • Retro Synthetic Analysis, or Is Nature Perfect?  Newsletter
  • Scripps Research Institute Scientists Create Extremely Potent and Improved New Derivatives of Successful Anticancer Drug  News Release
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Research

research overview

  • Synthetic Organic and Bioorganic Chemistry

    Our research interests include the total synthesis of natural products, development of new synthetic methodology, heterocyclic chemistry, bioorganic and medicinal chemistry, the study of DNA-agent interactions, and the chemistry of antitumor antibiotics. We place special emphasis on investigations to define the structure-function relationships of natural or designed agents.

    Synthetic Methodology

    Our ongoing investigations emphasize the development and application of hetero Diels-Alder reactions, the thermal reactions of cyclopropenone ketals, inter- and intramolecular acyl radical-alkene addition reactions, medium and large ring cyclization procedures, and combinatorial chemistry. In each instance, the methodology development represents the investigation of chemistry projected as a key step in the total synthesis of a natural or nonnatural product.

    Natural Products Total Synthesis

    Problems recently or currently being addressed include (+)-CC-1065 and functional analogs (antitumor antibiotic processing sequence selective DNA alkylation properties), duocarmycins (antitumor antibiotics possessing sequence selective DNA alkylation properties), yatakemycin, tropoloalkaloids, deoxybouvardin/bouvardin, K-13, OF4949-1 - OF4949-IV (immunopotentiating agents with confirmed antitumor activity), piperazinomycin, luzopeptins, sandramycin quinoxapeptins, thiocoraline and BE 22179, (DNA binding peptides with antitumor and antiviral properties), vancomycin, teicoplanin, chloropeptins, RP-66453, ramoplanin, bleomycin A2 (clinically employed antitumor agent), quinolinequinone antitumor antibiotics including streptonigrone, streptonigrin, and lavendamycin, isochrysohermidin, fredericamycin A and CI-920 (antitumor agents with topoisomerase I and II inhibitory activity), rhizoxin (antitumor antibiotic and potent mitotic inhibitor), combretastatins, and trikentrin A.

    Bioorganic Chemistry

    The orgin of interest in the specific agents detailed above rests with their properties and in many instances represents the selection of agents related by a projected property (e.g., (+)-CC-1065 and duocarmycin). Representatives of such efforts, studies on (+)-CC-1065 have been employed to identify agent structural features contributing to its sequence-selective DNA alkylation properties and the source of catalysis of the DNA alkylation reaction. Efforts are under way to develop DNA cross-linking agents of a predefined cross-link, to further understand the nature of the covalent and noncovalent agent-DNA interactions, and to apply this understanding to the de novo design of DNA-binding agents. 

    Collaborative efforts in securing biological data, 1H NMR of DNA-agent complexes, molecular modeling studies of large molecule-small molecule interactions, and experimental studies of DNA-agent interactions constitute an integral part of the program.

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Teaching

advisees

  • faculty mentoring relationship

    • Garbaccio, Robert, Ph.D.  candidate, 1995 - 1999
  • graduate advising relationship

    • Litwin, Kevin Michael, Ph.D.  candidate, 2014 -
    • Moore, Maxwell Johnson, Ph.D.  candidate, 2018 -
    • Quinones, Ryan, Ph.D.  candidate, 2016 -
    • Wu, Zhichen, Ph.D.  candidate, 2018 -
    • Zeng, Xianhuang, Ph.D.  candidate, 2018 -
    • Zhu, Zixi, Ph.D.  candidate, 2019 -
    • Shukla, Vyom, Ph.D.  candidate, 2015 - 2019
    • Zhang, Jiajun, Ph.D.  candidate, 2014 - 2019
    • Zhou, Stephanie, Ph.D.  candidate, 2016 - 2019
    • Glinkerman, Christopher, Ph.D.  candidate, 2014 - 2018
    • Kornahrens, Anne, Ph.D.  candidate, 2012 - 2016
    • Sears, Justin, Ph.D.  candidate, 2011 - 2015
    • Duncan, Katharine, Ph.D.  candidate, 2009 - 2014
    • Rodriguez, Rodrigo, Ph.D.  candidate, 2009 - 2014
    • Anderson, Erin, Ph.D.  candidate, 2008 - 2013
    • Breazzano, Steven Philip, Ph.D.  candidate, 2010 - 2013
    • Otrubova, Katerina, Ph.D.  candidate, 2008 - 2013
    • Wolfe, Amanda, Ph.D.  candidate, 2009 - 2013
    • James, Robert C., Ph.D.  candidate, 2007 - 2012
    • Lajiness, James, Ph.D.  candidate, 2008 - 2012
    • Zuhl, Andrea M., Ph.D.  candidate, 2007 - 2012
    • Kato, Daisuke, Ph.D.  candidate, 2006 - 2011
    • Whitby, Landon, Ph.D.  candidate, 2006 - 2011
    • Patel, Paresma, Ph.D.  candidate, 2006 - 2010
    • Garfunkle, Joie, Ph.D.  candidate, 2005 - 2009
    • Macmillan, Karen Smith, Ph.D.  candidate, 2005 - 2009
    • Boger, Dale (Faculty Member) advising Lee, Sang Yeul 2003 - 2008
    • Clark, Ryan C, Ph.D.  candidate, 2004 - 2008
    • DeMartino, Jessica, Ph.D.  candidate, 2004 - 2008
    • Lee, Sang Yeul, Ph.D.  candidate, 2004 - 2008
    • Schnermann, Martin, Ph.D.  candidate, 2004 - 2008
    • Slown, Corin Deann, Ph.D.  candidate, 2004 - 2008
    • Haq, Nadia, Ph.D.  candidate, 2003 - 2007
    • Tao, Houchao, Ph.D.  candidate, 2003 - 2007
    • Tichenor, Mark, Ph.D.  candidate, 2003 - 2007
    • Trzupek, John, Ph.D.  candidate, 2002 - 2006
    • Capps, Kevin J, Ph.D.  candidate, 2001 - 2005
    • Crowley, Brendan Michael, Ph.D.  candidate, 2001 - 2005
    • Kastrinsky, David, Ph.D.  candidate, 2001 - 2005
    • Krenitsky, Paul, Ph.D.  candidate, 1999 - 2003
    • Soenen, Danielle, Ph.D.  candidate, 1999 - 2003
    • Tse, Winston, Ph.D.  candidate, 1999 - 2003
    • Wolkenberg, Scott, Ph.D.  candidate, 1999 - 2003
    • Wilkie, Gordon, Ph.D.  candidate, 1998 - 2002
    • Hong, Jiyong, Ph.D.  candidate, 1997 - 2001
    • Castle, Steven Lane, Ph.D.  candidate, 1996 - 2000
    • Goldberg, Joel, Ph.D.  candidate, 1995 - 2000
    • Boyce, Christopher William, Ph.D.  candidate, 1995 - 1999
    • Cai, Hui, Ph.D.  candidate, 1995 - 1999
    • Lewis, Bryan, Ph.D.  candidate, 1994 - 1999
    • Johnson, Doug, Ph.D.  candidate, 1992 - 1997
    • Patterson, Jean, Ph.D.  candidate, 1993 - 1997
    • Haynes, Nancy-Ellen, Ph.D.  candidate, 1992 - 1996
    • Tarby, Christine, Ph.D.  candidate, 1994 - 1996
    • Zhou, Jiacheng, Ph.D.  candidate, 1992 - 1996
    • Zhu, Yan, Ph.D.  candidate, 1992 - 1995
  • postdoc or fellow advising relationship

    • Otrubova, Katerina, Ph.D.  candidate, 2013 - 2014
    • Va, Porino Jinjo, Ph.D.  candidate, 2007 - 2009
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Background

education and training

  • Ph.D. in Chemistry, Harvard University , with Dr. E. J. Corey 1980
  • B.S. in Chemistry, The University of Kansas 1975

awards and honors

  • E.C. Taylor Senior Award in Heterocyclic Chemistry, conferred by International Society of Heterocyclic Chemistry, 2019
  • Member (National Academy of Sciences), 2014
  • Fellow of the American Academy of Arts and Sciences, conferred by American Academy of Arts & Sciences, 2003
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Contact

full name

  • Dale L. Boger

geographic location

  • Scripps California 

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