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Blackmond, Donna
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Blackmond, Donna

Faculty Member
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Positions

  • 2018 - co-Chair, Chemistry , Scripps Research
  • 2009 - Professor, Chemistry , Scripps Research
  • 2009 - Faculty Member, Skaggs Graduate School of Chemical and Biological Sciences , Scripps Research
  • 2004 - 2010 Chair in Catalysis, Imperial College London
  • 2004 - 2010 Professor of Chemistry, Imperial College London
  • 2004 - 2010 Professor of Chemical Engineering, Imperial College London
  • 1999 - 2003 Professor and Chair in Physical Chemistry, University of Hull
  • 1996 - 1999 Group Leader, Max Planck Institute for Coal Research
  • 1992 - 1999 Adjunct Professor of Chemical Engineering, University of Pittsburgh
  • 1995 - 1996 Professor of Technical Chemistry, University of Essen
  • 1992 - 1995 Associate Director, Technical Operations, Merck & Co., Inc.
  • 1989 - 1992 Associate Professor of Chemical Engineering and BP America Faculty Fellow, University of Pittsburgh
  • 1984 - 1989 Assistant Professor of Chemical Engineering, University of Pittsburgh
Dr. Donna Blackmond focuses on mechanistic aspects of the synthesis of complex organic molecules by catalytic routes, particularly asymmetric catalysis with application in pharmaceutical processes. Her group also investigates nonlinear effects of catalyst enantiopurity in stoichiometric, catalytic and autocatalytic reactions. Another area of fundamental interest is in probing the origin of biological homochirality.

Contact

  • blackmon@scripps.edu

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  • Donna Blackmond, Ph.D.
  • Blackmond Laboratory
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Publications

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  • 56

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  • academic article

    • Blackmond, D. G. Autocatalytic Models for the Origin of Biological Homochirality Chemical Reviews  2020 120:4831-4847  DOI:10.1021/acs.chemrev.9b00557  PMID:31797671
    • Murray, J. I., Sanders, J. N., Richardson, P. F., Houk, K. N., Blackmond, D. G. Isotopically directed symmetry breaking and enantioenrichment in attrition-enhanced deracemization Journal of the American Chemical Society  2020 142:3873-3879  DOI:10.1021/jacs.9b11422  PMID:32027134
    • Wei, B., Sharland, J. C., Lin, P., Wilkerson-Hill, S. M., Fullilove, F. A., McKinnon, S., Blackmond, D. G., Davies, H. M. L. In situ kinetic studies of Rh(II)-catalyzed asymmetric cyclopropanation with low catalyst loadings ACS Catalysis  2020 10:1161-1170  DOI:10.1021/acscatal.9b04595
    • Schmidt, O. P., Blackmond, D. G. Temperature-Scanning Reaction Protocol Offers Insights into Activation Parameters in the Buchwald-Hartwig Pd-Catalyzed Amination of Aryl Halides ACS Catalysis  2020 10:8926-8932  DOI:10.1021/acscatal.0c01929
    • Hawbaker, N. A., Blackmond, D. G. Energy threshold for chiral symmetry breaking in molecular self-replication Nature Chemistry  2019 11:957-962  DOI:10.1038/s41557-019-0321-y  PMID:31548669
    • Xiang, J., Shang, M., Kawamata, Y., Lundberg, H., Reisberg, S. H., Chen, M., Mykhailiuk, P., Beutner, G., Collins, M. R., Davies, A., Del Bel, M., Gallego, G. M., et al. Hindered dialkyl ether synthesis with electrogenerated carbocations Nature  2019 573:398-402  DOI:10.1038/s41586-019-1539-y  PMID:31501569
    • Schmidt, O. P., Dechert-Schmitt, A. M., Garnsey, M. R., Wisniewska, H. M., Blackmond, D. G. Kinetic analysis of catalytic organic reactions using a temperature scanning protocol Chemcatchem  2019 11:3808-3813  DOI:10.1002/cctc.201900560
    • Wisniewski, S. R., Savage, S. A., Romero, E. O., Eastgate, M. D., Tan, Y., Simmons, E. M., Plata, R. E., Sowa Jr., J. R., Blackmond, D. G. Utilizing native directing groups: mechanistic understanding of a direct arylation leads to formation of tetracyclic heterocycles via tandem intermolecular, intramolecular C-H activation Journal of Organic Chemistry  2019 84:7961-7970  DOI:10.1021/acs.joc.9b00823  PMID:31117568
    • Dechert-Schmitt, A. M., Garnsey, M. R., Wisniewska, H. M., Murray, J. I., Lee, T., Kung, D. W., Sach, N., Blackmond, D. G. Highly modular synthesis of 1,2-diketones via multicomponent coupling reactions of isocyanides as CO equivalents ACS Catalysis  2019 9:4508-4515  DOI:10.1021/acscatal.9b00581
    • Blackmond, D. G. The origin of biological homochirality Cold Spring Harbor Perspectives in Biology  2019 11  DOI:10.1101/cshperspect.a032540  PMID:30824575
    • Wang, J., Shang, M., Lundberg, H., Feu, K. S., Hecker, S. J., Qin, T., Blackmond, D. G., Baran, P. S. Cu-catalyzed decarboxylative borylation ACS Catalysis  2018 8:9537-9542  DOI:10.1021/acscatal.8b02928
    • Wang, J., Lundberg, H., Asai, S., Martin-Acosta, P., Chen, J. S., Brown, S., Farrell, W., Dushin, R. G., O'Donnell, C. J., Ratnayake, A. S., Richardson, P., Liu, Z., et al. Kinetically guided radical-based synthesis of C(sp(3))-C(sp(3)) linkages on DNA Proceedings of the National Academy of Sciences of the United States of America  2018 115:E6404-E6410  DOI:10.1073/pnas.1806900115  PMID:29946037  PMCID:PMC6048552
    • Mower, M. P., Blackmond, D. G. In-situ monitoring of enantiomeric excess during a catalytic kinetic resolution ACS Catalysis  2018 8:5977-5982  DOI:10.1021/acscatal.8b01411
    • Hawbaker, N. A., Blackmond, D. G. Rationalization of asymmetric amplification via autocatalysis triggered by isotopically chiral molecules ACS Central Science  2018 4:776-780  DOI:10.1021/acscentsci.8b00297  PMID:29974074  PMCID:PMC6026777
    • Hill, D. E., Pei, Q. L., Zhang, E. X., Gage, J. R., Yu, J. Q., Blackmond, D. G. A general protocol for addressing speciation of the active catalyst applied to ligand-accelerated enantioselective C(sp(3))-H bond arylation ACS Catalysis  2018 8:1528-1531  DOI:10.1021/acscatal.8b00103
    • Hill, D. E., Bay, K. L., Yang, Y. F., Plata, R. E., Takise, R., Houk, K. N., Yu, J. Q., Blackmond, D. G. Dynamic ligand exchange as a mechanistic probe in Pd-catalyzed enantioselective C-H functionalization reactions using monoprotected amino acid ligands Journal of the American Chemical Society  2017 139:18500-18503  DOI:10.1021/jacs.7b11962  PMID:29215885
    • Gallagher, W. P., Soumeillant, M., Chen, K., Fox, R. J., Hsiao, Y., Mack, B., Iyer, V., Fan, J., Zhu, J., Beutner, G., Silverman, S. M., Fanfair, D. D., et al. Preparation of the HIV attachment inhibitor BMS-663068. Part 7. Development of a regioselective ullmann-Goldberg-Buchwald reaction Organic Process Research & Development  2017 21:1156-1165  DOI:10.1021/acs.oprd.7b00191
    • Plata, R. E., Hill, D. E., Haines, B. E., Musaev, D. G., Chu, L., Hickey, D. P., Sigman, M. S., Yu, J. Q., Blackmond, D. G. A role for Pd(IV) in catalytic enantioselective C-H functionalization with monoprotected amino acid ligands under mild conditions Journal of the American Chemical Society  2017 139:9238-9245  DOI:10.1021/jacs.7b03716  PMID:28605190
    • Liu, W. B., Schuman, D. P., Yang, Y. F., Toutov, A. A., Liang, Y., Klare, H. F. T., Nesnas, N., Oestreich, M., Blackmond, D. G., Virgil, S. C., Banerjee, S., Zare, R. N., et al. Potassium tert-butoxide-catalyzed dehydrogenative C-H silylation of heteroaromatics: A combined experimental and computational mechanistic study Journal of the American Chemical Society  2017 139:6867-6879  DOI:10.1021/jacs.6b13031  PMID:28403611
    • Wagner, A. J., Zubarev, D. Y., Aspuru-Guzik, A., Blackmond, D. G. Chiral sugars drive enantioenrichment in prebiotic amino acid synthesis ACS Central Science  2017 3:322-328  DOI:10.1021/acscentsci.7b00085  PMID:28470050  PMCID:PMC5408343
    • Gherase, D., Hazen, R. M., Krishnamurthy, R., Blackmond, D. G. Mineral-induced enantioenrichment of tartaric acid Synlett  2017 28:89-92  DOI:10.1055/s-0036-1588912
    • Wagner, A. J., Blackmond, D. G. The future of prebiotic chemistry ACS Central Science  2016 2:775-777  DOI:10.1021/acscentsci.6b00336  PMID:27924306  PMCID:PMC5126717
    • Stich, M., Ribo, J. M., Blackmond, D. G., Hochberg, D. Necessary conditions for the emergence of homochirality via autocatalytic self-replication Journal of Chemical Physics  2016 145  DOI:10.1063/1.4961021  PMID:27544091
    • Shi, Q., Mower, M. P., Blackmond, D. G., Rebek Jr., J. Water-soluble cavitands promote hydrolyses of long-chain diesters Proceedings of the National Academy of Sciences of the United States of America  2016 113:9199-9203  DOI:10.1073/pnas.1610006113  PMID:27482089  PMCID:PMC4995975
    • Masseroni, D., Mosca, S., Mower, M. P., Blackmond, D. G., Rebek Jr., J. Cavitands as reaction vessels and blocking groups for selective reactions in water Angewandte Chemie-International Edition  2016 55:8290-8293  DOI:10.1002/anie.201602355  PMID:27254667
    • Hawbaker, N., Wittgrove, E., Christensen, B., Sach, N., Blackmond, D. G. Dispersion in compartmentalized flow systems: influence of flow patterns on reactivity Organic Process Research & Development  2016 20:465-473  DOI:10.1021/op500360w
    • Bures, J., Armstrong, A., Blackmond, D. G. Explaining anomalies in enamine catalysis: "downstream species" as a new paradigm for stereocontrol Accounts of Chemical Research  2016 49:214-222  DOI:10.1021/acs.accounts.5b00394  PMID:26830669
    • Ji, Y., Plata, R. E., Regens, C. S., Hay, M., Schmidt, M., Razler, T., Qiu, Y., Geng, P., Hsiao, Y., Rosner, T., Eastgate, M. D., Blackmond, D. G. Mono-oxidation of bidentate bis-phosphines in catalyst activation: kinetic and mechanistic studies of a Pd/xantphos-catalyzed C-H functionalization Journal of the American Chemical Society  2015 137:13272-13281  DOI:10.1021/jacs.5b01913  PMID:26461028
    • Blackmond, D. G. Kinetic profiling of catalytic organic reactions as a mechanistic tool Journal of the American Chemical Society  2015 137:10852-10866  DOI:10.1021/jacs.5b05841  PMID:26285166
    • Ruiz-Castillo, P., Blackmond, D. G., Buchwald, S. L. Rational ligand design for the arylation of hindered primary amines guided by reaction progress kinetic analysis Journal of the American Chemical Society  2015 137:3085-3092  DOI:10.1021/ja512903g  PMID:25651374  PMCID:PMC4379963
    • Mower, M. P., Blackmond, D. G. Mechanistic rationalization of unusual sigmoidal kinetic profiles in the Machetti-De Sarlo cycloaddition reaction Journal of the American Chemical Society  2015 137:2386-2391  DOI:10.1021/ja512753v  PMID:25611219
    • Ji, Y., Benkovics, T., Beutner, G. L., Sfouggatakis, C., Eastgate, M. D., Blackmond, D. G. Mechanistic insights into the vanadium-catalyzed Achmatowicz rearrangement of furfurol Journal of Organic Chemistry  2015 80:1696-1702  DOI:10.1021/jo502641d  PMID:25562708
    • O'Brien, A. G., Maruyama, A., Inokuma, Y., Fujita, M., Baran, P. S., Blackmond, D. G. Radical C-H functionalization of heteroarenes under electrochemical control Angewandte Chemie-International Edition  2014 53:11868-11871  DOI:10.1002/anie.201407948  PMID:25209429  PMCID:PMC4214156
    • Bures, J., Dingwall, P., Armstrong, A., Blackmond, D. G. Rationalization of an unusual solvent-induced inversion of enantiomeric excess in organocatalytic selenylation of aldehydes Angewandte Chemie-International Edition  2014 53:8700-8704  DOI:10.1002/anie.201404327  PMID:25044727
    • Gherase, D., Conroy, D., Matar, O. K., Blackmond, D. G. Experimental and theoretical study of the emergence of single chirality in attrition-enhanced deracemization Crystal Growth and Design  2014 14:928-937  DOI:10.1021/cg401072d
    • Ji, Y., Blackmond, D. G. The role of reversibility in the enantioselective conjugate addition of alpha,alpha-disubstituted aldehydes to nitro-olefins catalyzed by primary amine thioureas Catalysis Science & Technology  2014 4:3505-3509  DOI:10.1039/c4cy00648h
    • O'Hara, F., Blackmond, D. G., Baran, P. S. Radical-based regioselective C-H functionalization of electron-deficient heteroarenes: scope, tunability, and predictability Journal of the American Chemical Society  2013 135:12122-12134  DOI:10.1021/ja406223k  PMID:23859263  PMCID:PMC3776592
    • Baxter, R. D., Blackmond, D. G. In situ kinetic studies of the trifluoromethylation of caffeine with Zn(SO2CF3)(2) Tetrahedron  2013 69:5604-5608  DOI:10.1016/j.tet.2013.04.007
    • Hein, J. E., Gherase, D., Blackmond, D. G. Chemical and physical models for the emergence of biological homochirality Topics in Current Chemistry  2013 333:83-108  DOI:10.1007/128_2012_397  PMID:23271377
    • Bures, J., Armstrong, A., Blackmond, D. G. The interplay of thermodynamics and kinetics in dictating organocatalytic reactivity and selectivity Pure and Applied Chemistry  2013 85:1919-1934  DOI:10.1351/pac-con-13-01-14
    • Hein, J. E., Blackmond, D. G. On the origin of single chirality of amino acids and sugars in biogenesis Accounts of Chemical Research  2012 45:2045-2054  DOI:10.1021/ar200316n  PMID:22353168
    • Hein, J. E., Cao, B. H., Viedma, C., Kellogg, R. M., Blackmond, D. G. Pasteur's tweezers revisited: on the mechanism of attrition-enhanced deracemization and resolution of chiral conglomerate solids Journal of the American Chemical Society  2012 134:12629-12636  DOI:10.1021/ja303566g  PMID:22779695
    • Baxter, R. D., Sale, D., Engle, K. M., Yu, J. Q., Blackmond, D. G. Mechanistic rationalization of unusual kinetics in Pd-catalyzed C-H olefination Journal of the American Chemical Society  2012 134:4600-4606  DOI:10.1021/ja207634t  PMID:22324814
    • Fujiwara, Y., Dixon, J. A., Rodriguez, R. A., Baxter, R. D., Dixon, D. D., Collins, M. R., Blackmond, D. G., Baran, P. S. A new reagent for direct difluoromethylation Journal of the American Chemical Society  2012 134:1494-1497  DOI:10.1021/ja211422g  PMID:22229949  PMCID:PMC3269891
    • Bures, J., Armstrong, A., Blackmond, D. G. Curtin-Hammett paradigm for stereocontrol in organocatalysis by diarylprolinol ether catalysts Journal of the American Chemical Society  2012 134:6741-6750  DOI:10.1021/ja300415t  PMID:22452319
    • Bures, J., Armstrong, A., Blackmond, D. G. Kinetic correlation between aldehyde/enamine stereoisomers in reactions between aldehydes with alpha-stereocenters and chiral pyrrolidine-based catalysts Chemical Science  2012 3:1273-1277  DOI:10.1039/c2sc01082h
    • Gehring, T., Quaranta, M., Odell, B., Blackmond, D. G., Brown, J. M. Observation of a transient intermediate in Soai's asymmetric autocatalysis: Insights from 1H NMR turnover in real time Angewandte Chemie-International Edition  2012 51:9539-9542  DOI:10.1002/anie.201203398  PMID:22936384
    • Blackmond, D. G. The origin of biological homochirality Philosophical Transactions of the Royal Society B-Biological Sciences  2011 366:2878-2884  DOI:10.1098/rstb.2011.0130  PMID:21930578  PMCID:PMC3158912
    • Hein, J. E., Bures, J., Lam, Y. H., Hughes, M., Houk, K. N., Armstrong, A., Blackmond, D. G. Enamine carboxylates as stereodetermining intermediates in prolinate catalysis Organic Letters  2011 13:5644-5647  DOI:10.1021/ol2023533  PMID:21958394
    • Hein, J. E., Tse, E., Blackmond, D. G. A route to enantiopure RNA precursors from nearly racemic starting materials Nature Chemistry  2011 3:704-706  DOI:10.1038/nchem.1108  PMID:21860459
    • Ji, Y. N., Brueckl, T., Baxter, R. D., Fujiwara, Y., Seiple, I. B., Su, S., Blackmond, D. G., Baran, P. S. Innate C-H trifluoromethylation of heterocycles Proceedings of the National Academy of Sciences of the United States of America  2011 108:14411-14415  DOI:10.1073/pnas.1109059108  PMID:21844378  PMCID:PMC3167544
    • Hein, J. E., Armstrong, A., Blackmond, D. G. Kinetic profiling of prolinate-catalyzed alpha-amination of aldehydes Organic Letters  2011 13:4300-4303  DOI:10.1021/ol201639z  PMID:21761822
    • Bures, J., Armstrong, A., Blackmond, D. G. Mechanistic rationalization of organocatalyzed conjugate addition of linear aldehydes to nitro-olefins Journal of the American Chemical Society  2011 133:8822-8825  DOI:10.1021/ja203660r  PMID:21568340
    • Ferretti, A. C., Brennan, C., Blackmond, D. G. Reservoir catalysis: rationalization of anomalous reaction orders in Pd-catalyzed amination of aryl halides Inorganica Chimica Acta  2011 369:292-295  DOI:10.1016/j.ica.2011.01.018
    • Quaranta, M., Gehring, T., Odell, B., Brown, J. M., Blackmond, D. G. Unusual inverse temperature dependence on reaction rate in the asymmetric autocatalytic alkylation of pyrimidyl aldehydes Journal of the American Chemical Society  2010 132:15104-15107  DOI:10.1021/ja103204w  PMID:20942400
    • Blackmond, D. G. Kinetic aspects of non-linear effects in asymmetric synthesis, catalysis, and autocatalysis Tetrahedron-Asymmetry  2010 21:1630-1634  DOI:10.1016/j.tetasy.2010.03.034
    • Blackmond, D. G., Moran, A., Hughes, M., Armstrong, A. Unusual reversal of enantioselectivity in the proline-mediated alpha-amination of aldehydes induced by tertiary amine additives Journal of the American Chemical Society  2010 132:7598-7899  DOI:10.1021/ja102718x  PMID:20465280
    • Blackmond, D. G. The origin of biological homochirality Cold Spring Harbor Perspectives in Biology  2010 2:a002147  DOI:10.1101/cshperspect.a002147  PMID:20452962  PMCID:PMC2857173
    • Viedma, C., Verkuijl, B. J. V., Ortiz, J. E., de Torres, T., Kellogg, R. M., Blackmond, D. G. Solution-phase racemization in the presence of an enantiopure solid phase Chemistry-a European Journal  2010 16:4932-4937  DOI:10.1002/chem.200902983  PMID:20358554
    • Valera, F. E., Quaranta, M., Moran, A., Blacker, J., Armstrong, A., Cabral, J. T., Blackmond, D. G. The flow's the thing ... Or is it? Assessing the merits of homogeneous reactions in flask and flow Angewandte Chemie-International Edition  2010 49:2478-2485  DOI:10.1002/anie.200906095  PMID:20187051
    • Zotova, N., Moran, A., Armstrong, A., Blackmond, D. G. A coherent mechanistic rationale for additive effects and autoinductive behaviour in proline-mediated reactions Advanced Synthesis & Catalysis  2009 351:2765-2769  DOI:10.1002/adsc.200900665
    • Zotova, N., Broadbelt, L. J., Armstrong, A., Blackmond, D. G. Kinetic and mechanistic studies of proline-mediated direct intermolecular aldol reactions Bioorganic & Medicinal Chemistry Letters  2009 19:3934-3937  DOI:10.1016/j.bmcl.2009.03.112  PMID:19362473
    • Blackmond, D. G. Challenging the concept of "recycling" as a mechanism for the evolution of homochirality in chemical reactions Chirality  2009 21:359-362  DOI:10.1002/chir.20592  PMID:18570293
    • Blackmond, D. G. "If pigs could fly" chemistry: A tutorial on the principle of microscopic reversibility Angewandte Chemie-International Edition  2009 48:2648-2654  DOI:10.1002/anie.200804566  PMID:19117002
    • Blackmond, D. G. An examination of the role of autocatalytic cycles in the chemistry of proposed primordial reactions Angewandte Chemie-International Edition  2009 48:386-390  DOI:10.1002/anie.200804565  PMID:19053125
    • Izumi, T., Blackmond, D. G. The double solubility rule holds for racemizing enantiomers Chemistry-a European Journal  2009 15:3065-3068  DOI:10.1002/chem.200801847  PMID:19222072
    • Viedma, C., Ortiz, J. E., de Torres, T., Izumi, T., Blackmond, D. G. Evolution of solid phase homochirality for a proteinogenic amino acid Journal of the American Chemical Society  2008 130:15274-15275  DOI:10.1021/ja8074506  PMID:18954052
    • Blackmond, D. G. Response to "comment on 'a re-examination of reversibility in reaction models for the spontaneous emergence of homochirality'" Journal of Physical Chemistry B  2008 112:9553-9555  DOI:10.1021/jp8040378
    • Ferretti, A. C., Mathew, J. S., Ashworth, I., Purdy, M., Brennan, C., Blackmond, D. G. Mechanistic inferences derived from competitive catalytic reactions: Pd(binap)-catalyzed amination of aryl halides Advanced Synthesis & Catalysis  2008 350:1007-1012  DOI:10.1002/adsc.200800006
    • Noorduin, W. L., Izumi, T., Millemaggi, A., Leeman, M., Meekes, H., Van Enckevort, W. J. P., Kellogg, R. M., Kaptein, B., Vlieg, E., Blackmond, D. G. Emergence of a single solid chiral state from a nearly racemic amino acid derivative Journal of the American Chemical Society  2008 130:1158-1159  DOI:10.1021/ja7106349  PMID:18173274
    • Blackmond, D. G., Matar, O. K. Re-examination of reversibility in reaction models for the spontaneous emergence of homochirality Journal of Physical Chemistry B  2008 112:5098-5104  DOI:10.1021/jp7118586  PMID:18370430
    • Zotova, N., Franzke, A., Armstrong, A., Blackmond, D. G. Clarification of the role of water in proline-mediated aldol reactions Journal of the American Chemical Society  2007 129:15100-15101  DOI:10.1021/ja0738881  PMID:18001021
    • Ferretti, A. C., Mathew, J. S., Blackmond, D. G. Reaction calorimetry as a tool for understanding reaction mechanisms: application to Pd-catalyzed reactions Industrial & Engineering Chemistry Research  2007 46:8584-8589  DOI:10.1021/ie070050d
    • Klussmann, M., Izumi, T., White, A. J. P., Armstrong, A., Blackmond, D. G. Emergence of solution-phase homochirality via crystal engineering of amino acids Journal of the American Chemical Society  2007 129:7657-7660  DOI:10.1021/ja0708870  PMID:17530759
    • Blackmond, D. G. "Chiral amnesia" as a driving force for solid-phase homochirality Chemistry-a European Journal  2007 13:3290-3295  DOI:10.1002/chem.200601463  PMID:17366493
    • Phua, P. H., Mathew, S. P., White, A. J. P., de Vries, J. G., Blackmond, D. G., Hii, K. K. Elucidating the mechanism of the asymmetric aza-Michael reaction Chemistry-a European Journal  2007 13:4602-4613  DOI:10.1002/chem.200601706  PMID:17352437
    • Blackmond, D. G., Klussmann, M. Investigating the evolution of biomolecular homochirality AIChE Journal  2007 53:2-8  DOI:10.1002/aic.11024
    • Blackmond, D. G. Response to "Comments on a possible transition to solid-phase homochirality" Chemistry-a European Journal  2007 13:10306-10311  DOI:10.1002/chem.200701568
    • Blackmond, D. G., Klussmann, M. Spoilt for choice: Assessing phase behavior models for the evolution of homochirality Chemical Communications  2007 3990-3996  DOI:10.1039/b709314b  PMID:17912393
    • Blackmond, D. G., Armstrong, A., Coombe, V., Wells, A. Water in organocatalytic processes: Debunking the myths Angewandte Chemie-International Edition  2007 46:3798-3800  DOI:10.1002/anie.200604952  PMID:17361975
    • Blackmond, D. G., Schultz, T., Mathew, J. S., Loew, C., Rosner, T., Pfaltz, A. Comprehensive kinetic screening of palladium catalysts for heck reactions Synlett  2006 3135-3139  DOI:10.1055/s-2006-951514
    • Mathew, J. S., Klussmann, M., Iwamura, H., Valera, F., Futran, A., Emanuelsson, E. A. C., Blackmond, D. G. Investigations of Pd-catalyzed ArX coupling reactions informed by reaction progress kinetic analysis Journal of Organic Chemistry  2006 71:4711-4722  DOI:10.1021/jo052409i  PMID:16776495
    • Blackmond, D. G., Hodnett, N. S., Lloyd-Jones, G. C. Mechanistic implications of pseudo zero order kinetics in kinetic resolutions Journal of the American Chemical Society  2006 128:7450-7451  DOI:10.1021/ja062173f  PMID:16756293
    • Klussmann, M., Iwamura, H., Mathew, S. P., Wells, D. H., Pandya, U., Armstrong, A., Blackmond, D. G. Thermodynamic control of asymmetric amplification in amino acid catalysis Nature  2006 441:621-623  DOI:10.1038/nature04780  PMID:16738656
    • Blackmond, D. G., Ropic, M., Stefinovic, M. Kinetic studies of the asymmetric transfer hydrogenation of imines with formic acid catalyzed by Rh-diamine catalysts Organic Process Research & Development  2006 10:457-463  DOI:10.1021/op060033k
    • Shekhar, S., Ryberg, P., Hartwig, J. F., Mathew, J. S., Blackmond, D. G., Strieter, E. R., Buchwald, S. L. Reevaluation of the mechanism of the amination of aryl halides catalyzed by BINAP-ligated palladium complexes Journal of the American Chemical Society  2006 128:3584-3591  DOI:10.1021/ja045533c  PMID:16536531
    • Blackmond, D. G. Mechanistic study of the soai autocatalytic reaction informed by kinetic analysis Tetrahedron-Asymmetry  2006 17:584-589  DOI:10.1016/j.tetasy.2006.01.012
    • Mathew, S. P., Klussmann, M., Iwamura, H., Wells, D. H., Armstrong, A., Blackmond, D. G. A mechanistic rationalization of unusual kinetic behavior in proline-mediated C-O and C-N bond-forming reactions Chemical Communications  2006 4291-4293  DOI:10.1039/b609926b  PMID:17047844
    • Klussmann, M., Mathew, S. R., Iwamura, H., Wells, D. H., Armstrong, A., Blackmond, D. G. Kinetic rationalization of nonlinear effects in asymmetric catalysis based on phase behavior Angewandte Chemie-International Edition  2006 45:7989-7992  DOI:10.1002/anie.200602521  PMID:17061299
    • Klussmann, M., White, A. J. R., Armstrong, A., Blackmond, D. G. Rationalization and prediction of solution enantiomeric excess in ternary phase systems Angewandte Chemie-International Edition  2006 45:7985-7989  DOI:10.1002/anie.200602520  PMID:16986192
    • Mathew, S. P., Gunathilagan, S., Roberts, S. M., Blackmond, D. G. Mechanistic insights from reaction progress kinetic analysis of the polypeptide-catalyzed epoxidation of chalcone Organic Letters  2005 7:4847-4850  DOI:10.1021/ol051708r  PMID:16235904
    • Reetz, M. T., Meiswinkel, A., Mehler, G., Angermund, K., Graf, M., Thiel, W., Mynott, R., Blackmond, D. G. Why are BINOL-based monophosphites such efficient ligands in Rh-catalyzed asymmetric olefin hydrogenation? Journal of the American Chemical Society  2005 127:10305-10313  DOI:10.1021/ja052025+  PMID:16028942
    • Arseniyadis, S., Subhash, P. V., Valleix, A., Mathew, S. P., Blackmond, D. G., Wagner, A., Mioskowski, C. Tuning the enantioselective N-acetylation of racemic amines: A spectacular salt effect Journal of the American Chemical Society  2005 127:6138-6139  DOI:10.1021/ja051302+  PMID:15853296
    • Strieter, E. R., Blackmond, D. G., Buchwald, S. L. The role of chelating diamine ligands in the goldberg reaction: a kinetic study on the copper-catalyzed amidation of aryl iodides Journal of the American Chemical Society  2005 127:4120-4121  DOI:10.1021/ja050120c  PMID:15783164
    • Blackmond, D. G. Reaction progress kinetic analysis: a powerful methodology for mechanistic studies of complex catalytic reactions Angewandte Chemie-International Edition  2005 44:4302-4320  DOI:10.1002/anie.200462544  PMID:15997457
    • Iwamura, H., Wells, D. H., Mathew, S. P., Klussmann, M., Armstrong, A., Blackmond, D. G. Probing the active catalyst in product-accelerated proline-mediated reactions Journal of the American Chemical Society  2004 126:16312-16313  DOI:10.1021/ja0444177  PMID:15600319
    • Iwamura, H., Mathew, S. P., Blackmond, D. G. In situ catalyst improvement in the proline-mediated alpha-amination of aldehydes Journal of the American Chemical Society  2004 126:11770-11771  DOI:10.1021/ja046258x  PMID:15382893
    • Richards, S., Ropic, M., Blackmond, D., Walmsley, A. Quantitative determination of the catalysed asymmetric transfer hydrogenation of 1-methyl-6,7-dimethoxy-3,4-dihydroisoquinoline using in situ FTIR and multivariate curve resolution Analytica Chimica Acta  2004 519:1-9  DOI:10.1016/j.aca.2004.05.021
    • LeBars, J., Dini, S., Hawkins, J. M., Blackmond, D. G. Mechanistic insights into anomalous kinetic behaviour in the hydrogenation of a substituted nitrobenzene Advanced Synthesis & Catalysis  2004 346:943-946  DOI:10.1002/adsc.200303202
    • Blackmond, D. G. Asymmetric autocatalysis and its implications for the origin of homochirality Proceedings of the National Academy of Sciences of the United States of America  2004 101:5732-5736  DOI:10.1073/pnas.0308363101  PMID:15067112  PMCID:PMC395976
    • Buono, F. G., Iwamura, H., Blackmond, D. G. Physical and chemical rationalization for asymmetric amplification in autocatalytic reactions Angewandte Chemie-International Edition  2004 43:2099-2103  DOI:10.1002/anie.200353086  PMID:15083455
    • Nielsen, L. P. C., Stevenson, C. P., Blackmond, D. G., Jacobsen, E. N. Mechanistic investigation leads to a synthetic improvement in the hydrolytic kinetic resolution of terminal epoxides Journal of the American Chemical Society  2004 126:1360-1362  DOI:10.1021/ja038590z  PMID:14759192
    • Mathew, S. P., Iwamura, H., Blackmond, D. G. Amplification of enantiomeric excess in a proline-mediated reaction Angewandte Chemie-International Edition  2004 43:3317-3321  DOI:10.1002/anie.200453997  PMID:15213963
    • Strieter, E. R., Blackmond, D. G., Buchwald, S. L. Insights into the origin of high activity and stability of catalysts derived from bulky, electron-rich monophosphinobiaryl ligands in the Pd-catalyzed C-N bond formation Journal of the American Chemical Society  2003 125:13978-13980  DOI:10.1021/ja037932y  PMID:14611232
    • Buono, F. G., Blackmond, D. G. Kinetic evidence for a tetrameric transition state in the asymmetric autocatalytic alkylation of pyrimidyl aldehydes Journal of the American Chemical Society  2003 125:8978-8979  DOI:10.1021/ja034705n  PMID:15369330
    • Singh, U. K., Strieter, E. R., Blackmond, D. G., Buchwald, S. L. Mechanistic insights into the Pd(BINAP)-catalyzed amination of aryl bromides: kinetic studies under synthetically relevant conditions Journal of the American Chemical Society  2002 124:14104-14114  DOI:10.1021/ja026885r  PMID:12440909
    • Buono, F., Walsh, P. J., Blackmond, D. G. Rationalization of anomalous nonlinear effects in the alkylation of substituted benzaldehydes Journal of the American Chemical Society  2002 124:13652-13653  DOI:10.1021/ja027406r  PMID:12431076
    • Blackmond, D. G. Requiem for the reaction rate equation? Catalysis Letters  2002 83:133-136  DOI:10.1023/a:1021041925818
    • Blackmond, D. G. Description of the condition for asymmetric amplification in autocatalytic reactions Advanced Synthesis & Catalysis  2002 344:156-158  DOI:10.1002/1615-4169(200202)344:2<156::aid-adsc156>3.0.co;2-1
    • Blackmond, D. G., McMillan, C. R., Ramdeehul, S., Schorm, A., Brown, J. M. Origins of asymmetric amplification in autocatalytic alkylzinc additions Journal of the American Chemical Society  2001 123:10103-10104  DOI:10.1021/ja0165133  PMID:11592892
    • Rosner, T., Pfaltz, A., Blackmond, D. G. Observation of unusual kinetics in Heck reactions of aryl halides: the role of non-steady-state catalyst concentration Journal of the American Chemical Society  2001 123:4621-4622  DOI:10.1021/ja005872f  PMID:11457257
    • Rosner, T., Le Bars, J., Pfaltz, A., Blackmond, D. G. Kinetic studies of heck coupling reactions using palladacycle catalysts: Experimental and kinetic modeling of the role of dimer species Journal of the American Chemical Society  2001 123:1848-1855  DOI:10.1021/ja00319le  PMID:11456804
    • Le Bars, J., Haussner, T., Lang, J., Pfaltz, A., Blackmond, D. G. A scale-transparent reaction calorimetric assay for rapid catalyst selection Advanced Synthesis & Catalysis  2001 343:207-214  DOI:10.1002/1615-4169(20010226)343:2<207::aid-adsc207>3.3.co;2-v
    • Blackmond, D. G. Kinetic resolution using enantioimpure catalysts: mechanistic considerations of complex rate laws Journal of the American Chemical Society  2001 123:545-553  DOI:10.1021/ja002562o  PMID:11456566
    • Rosner, T., Sears, P. J., Nugent, W. A., Blackmond, D. G. Kinetic investigations of product inhibition in the amino alcohol-catalyzed asymmetric alkylation of benzaldehyde with diethylzinc Organic Letters  2000 2:2511-2513  DOI:10.1021/ol006181r  PMID:10956534
    • Blackmond, D. G. Kinetic aspects of nonlinear effects in asymmetric catalysis Accounts of Chemical Research  2000 33:402-411  DOI:10.1021/ar990083s  PMID:10891058
    • Blackmond, D. G., Lightfoot, A., Pfaltz, A., Rosner, T., Schnider, P., Zimmerman, N. Enantioselective hydrogenation of olefins with phosphinooxazoline-iridium catalysts Chirality  2000 12:442-449  DOI:10.1002/(sici)1520-636x(2000)12:5/6<442::aid-chir25>3.0.co;2-f  PMID:10824167
    • Le Bars, J., Specht, U., Bradley, J. S., Blackmond, D. G. A catalytic probe of the surface of colloidal palladium particles using heck coupling reactions Langmuir  1999 15:7621-7625  DOI:10.1021/la990144v
    • Blackmond, D. G., Rosner, T., Pfaltz, A. Comprehensive kinetic screening of catalysts using reaction calorimetry Organic Process Research & Development  1999 3:275-280  DOI:10.1021/op990024u
    • Blackmond, D. G., Rosner, T., Neugebauer, T., Reetz, M. T. Kinetic influences on enantioselectivity for non-diastereopure catalyst mixtures Angewandte Chemie-International Edition  1999 38:2196-2199  DOI:10.1002/(sici)1521-3773(19990802)38:15<2196::aid-anie2196>3.0.co;2-9  PMID:10425479
    • Blackmond, D. G. Kinetic implications of nonlinear effects in asymmetric synthesis Journal of the American Chemical Society  1998 120:13349-13353  DOI:10.1021/ja982448u
    • Bohnen, F. M., Gamez, A., Blackmond, D. G. On the implications of hemiketal formation during ethyl pyruvate hydrogenation in alcohol solvents Journal of Catalysis  1998 179:335-338  DOI:10.1006/jcat.1998.2247
    • Blackmond, D. G. Comments on "Nature of initial transient period during enantioselective hydrogenation on Pt and Pd" by T. Mallat, Z. Bodnar, B. Minder, K. Borszeky, and A. Baiker Journal of Catalysis  1998 176:267-270  DOI:10.1006/jcat.1998.2080
    • Siedlaczek, G., Schwickardi, M., Kolb, U., Bogdanovic, B., Blackmond, D. G. Diastereoselective reductive amination reactions using novel metal-carbon catalysts prepared front inorganic grignard reagents Catalysis Letters  1998 55:67-72  DOI:10.1023/a:1019026711011
    • Blackmond, D. G., Leitner, W. Fine chemicals catalysis - Part II - Preface Topics in Catalysis  1998 5:U9-U10
    • Blackmond, D. G. Mathematical models of nonlinear effects in asymmetric catalysis: new insights based on the role of reaction rate Journal of the American Chemical Society  1997 119:12934-12939  DOI:10.1021/ja973049m
    • Wang, J., LeBlond, C., Reamer, R. A., Laquidara, J., Sowa, J. R., Blackmond, D. G. Kinetic influences on enantioselectivity in asymmetric catalytic hydrogenation Journal of Organometallic Chemistry  1997 548:65-72  DOI:10.1016/s0022-328x(97)00165-4
    • Blackmond, D. G., Leitner, W. Fine chemicals catalysis, part I - Preface Topics in Catalysis  1997 4:U9-U10
    • Wang, J., LeBlond, C., Landau, R. N., Laquidara, J., Sowa, J. R., Blackmond, D. G. Kinetic influences on enantioselectivity in asymmetric catalytic hydrogenation Journal of Molecular Catalysis A-Chemical  1997 115:495-502  DOI:10.1016/s1381-1169(96)00353-6
    • Wang, J., LeBlond, C., Orella, C. F., Sun, Y. K., Bradley, J. S., Blackmond, D. G. Modeling of kinetically coupled selective hydrogenation reactions: Kinetic rationalization of pressure effects on enantioselectivity Studies in Surface Science and Catalysis  1997 108:183-190
    • LeBlond, C., Wang, J., Larsen, R. D., Orella, C. J., Forman, A. L., Landau, R. N., Laquidara, J., Sowa, J. R., Blackmond, D. G., Sun, Y. K. Reaction calorimetry as an in-situ kinetic tool for characterizing complex reactions Thermochimica Acta  1996 289:189-207  DOI:10.1016/s0040-6031(96)03072-9
    • Sun, Y. K., Wang, J., Leblond, C., Landau, R. N., Blackmond, D. G. Asymmetric hydrogenation of ethyl pyruvate: Diffusion effects on enantioselectivity Journal of Catalysis  1996 161:759-765  DOI:10.1006/jcat.1996.0238
    • Wang, J., Sun, Y. K., Leblond, C., Landau, R. N., Blackmond, D. G. Asymmetric hydrogenation of ethyl pyruvate: Relationship between conversion and enantioselectivity Journal of Catalysis  1996 161:752-758  DOI:10.1006/jcat.1996.0237
    • Sun, Y. K., Landau, R. N., Wang, J., LeBlond, C., Blackmond, D. G. A re-examination of pressure effects on enantioselectivity in asymmetric catalytic hydrogenation Journal of the American Chemical Society  1996 118:1348-1353  DOI:10.1021/ja952988g
    • Sun, Y. K., LeBlond, C., Wang, J., Blackmond, D. G. Observation of a RuCl2((S)-((-))-tol-binap) (2).N(C2H5)(3)-catalyzed isomerization-hydrogenation network Journal of the American Chemical Society  1995 117:12647-12648  DOI:10.1021/ja00155a034
    • Landau, R. N., Singh, U., Gortsema, F., Sun, Y. K., Gomolka, S. C., Lam, T., Futran, M., Blackmond, D. G. A reaction calorimetric investigation of the hydrogenation of a substituted pyrazine Journal of Catalysis  1995 157:201-208  DOI:10.1006/jcat.1995.1280
    • Singh, U. K., Landau, R. N., Sun, Y. K., Leblond, C., Blackmond, D. G., Tanielyan, S. K., Augustine, R. L. Enantioselective catalysis - influence of conversion and bulk diffusion limitations on selectivity in the hydrogenation of ethyl pyruvate Journal of Catalysis  1995 154:91-97  DOI:10.1006/jcat.1995.1150
    • Wang, J., Oukaci, R., Wender, I., Blackmond, D. G. Alcohol synthesis from co/h-2 over co/cu/zno/al2o3 - in-situ addition of ch3no2 Journal of Catalysis  1995 153:100-107  DOI:10.1006/jcat.1995.1112
    • Landau, R. N., Blackmond, D. G. Scale-up heat-transfer based on reaction calorimetry Chemical Engineering Progress  1994 90:43-48
    • Blackmond, D. G. 15th Conference on Catalysis of Organic Reactions, 2–5 May, 1994, Phoenix, AZ Applied Catalysis A-General  1994 115:N7-N8  DOI:10.1016/0926-860x(94)80394-3
    • Landau, R. N., Blackmond, D. G., Tung, H. H. Calorimetric investigation of an exothermic reaction: kinetic and heat-flow modeling Industrial & Engineering Chemistry Research  1994 33:814-820  DOI:10.1021/ie00028a005
    • Blackmond, D. CHICAT - Chiral reactions in heterogeneous catalysis, Brussels, Belgium, October 25-26, 1993 Applied Catalysis A-General  1994 107:N23-N25  DOI:10.1016/0926-860x(94)85174-3
    • Waghray, A., Blackmond, D. G. Infrared spectroscopic studies of the adsorption and reaction of 3-methyl-2-butenal over alkali-promoted ru/sio2 catalysts Journal of Physical Chemistry  1993 97:6002-6006  DOI:10.1021/j100124a036
    • Holmlid, L., Engvall, K., Aman, C., Menon, P. G., Haller, G. L., Kochloefl, K., Pernicone, N., Baranski, A., Blackmond, D. G., Cameron, C., Aika, K., Fisher, G. B. A new approach to loss of alkali promoter from industrial catalysts - importance of excited-states of alkali Studies in Surface Science and Catalysis  1993 75:795-807
    • Badani, M. V., Eshelman, L. M., Delgass, W. N., Prins, R., Vannice, M. A., Suresh, D., Conner, W. C., Ponec, V., Blackmond, D. G., Homs, N., Bhasin, M. M. Acetonitrile synthesis from co, h2 and nh3 over fe/c and k,fe/c Studies in Surface Science and Catalysis  1993 75:1223-1234
    • Choudary, B. M., Rani, S. S., Rao, Y. V. S., Arntz, D., Kiricsi, I., Simons, K., Blackmond, D. G., Ratnasamy, P., Johnson, P., Holderich, W. An improved asymmetric oxidation of sulfides to sulfoxides by titanium pillared montmorillonite - the 1st example in heterogeneous catalysis Studies in Surface Science and Catalysis  1993 75:1247-1255
    • Schroder, U., Cider, L., Schoon, N. H., Baltanas, M. A., Blackmond, D. G., Datye, A. K., Conner, W. C., Hightower, J. W., Guo, X. X., Wang, D. An in-situ radioactive-tracer technique for studying adsorption-desorption dynamics on a working catalyst Studies in Surface Science and Catalysis  1993 75:643-657
    • Murrell, L. L., Tauster, S. J., Anderson, D. R., Bozonverduraz, F., Woo, S. I., Conner, W. C., Conesa, J. C., Blackmond, D. G., Ichikawa, M., Bartholomew, C. H. Laser raman characterization of surface phase precious-metal oxides formed on ceo2 micro domains generated within an alumina host by sol synthesis Studies in Surface Science and Catalysis  1993 75:681-690
    • Marinelli, Tblw, Vleeming, J. H., Ponec, V., Wang, D., Blackmond, D. G., Arntz, D., Jannes, G., Kunimori, K., Rochester, C. H. Reactions of multifunctional organic-compounds - hydrogenation of acrolein on modified pt-catalysts Studies in Surface Science and Catalysis  1993 75:1211-1222
    • Waghray, A., Oukaci, R., Blackmond, D. G. Selective hydrogenation of alpha,beta-unsaturated aldehydes over supported ru Studies in Surface Science and Catalysis  1993 75:2479-2482
    • Balakos, M. W., Chuang, S. S. C., Krishnamurthy, R., Srinivas, G., Johnston, P., Blackmond, D. G., Jackson, S. D., Joyner, R. W. The selective synthesis of c2+ oxygenates from syngas related reactions over ni-based and rh-based catalysts Studies in Surface Science and Catalysis  1993 75:1467-1478
    • Lin, S. D., Vannice, M. A., Herrmann, J. M., Wang, D., Apestequia, C., Duprez, D., Figueras, F., Conner, W. C., Kiperman, S. L., Hall, W. K., Blackmond, D. G., Grunert, W., et al. Toluene hydrogenation over supported platinum catalysts Studies in Surface Science and Catalysis  1993 75:861-874
    • Brusky, P., Blackmond, D. G. Meeting Reports. 14th International Conference on the Catalysis of Organic Reactions, Albuquerque, New Mexico, 27-29 April, 1992 Applied Catalysis A-General  1992 87:N13-N14  DOI:10.1016/0926-860X(92)80191-E
    • Waghray, A., Wang, J., Oukaci, R., Blackmond, D. G. Influence of alkali promoters in the selective hydrogenation of 3-methyl-2-butenal over ru/sio2 catalysts Journal of Physical Chemistry  1992 96:5954-5959  DOI:10.1021/j100193a056
    • Waghray, A., Oukaci, R., Blackmond, D. G. Diffusion effects in the hydrogenation of 3-methyl crotonaldehyde over zeolite-supported ru Catalysis Letters  1992 14:115-122  DOI:10.1007/bf00764225
    • Oukaci, R., Blackmond, D. G., Goodwin, J. G., Gallaher, G. R. Steady-state isotopic transient kinetic analysis investigation of CO—O(2) and CO—NO reactions over a commercial automotive catalyst ACS Symposium Series  1992 495:61-72  DOI:10.1021/bk-1992-0495.ch005
    • Blackmond, D. G., Oukaci, R., Blanc, B., Gallezot, P. Geometric and electronic effects in the selective hydrogenation of alpha,beta-unsaturated aldehydes over zeolite-supported metals Journal of Catalysis  1991 131:401-411  DOI:10.1016/0021-9517(91)90275-9
    • Cavalcanti, F. A. P., Oukaci, R., Wender, I., Blackmond, D. G. CH3NO2 addition to co hydrogenation over a RU/KY catalyst Journal of Catalysis  1991 128:311-319  DOI:10.1016/0021-9517(91)90291-b
    • Cavalcanti, F. A. P., Qukaci, R., Wender, I., Blackmond, D. G. Nitroethane as a probe molecule for CO hydrogenation over RU/SIO2 Journal of Catalysis  1990 123:270-274  DOI:10.1016/0021-9517(90)90175-j
    • Cavalcanti, F. A. P., Oukaci, R., Wender, I., Blackmond, D. G. Probe molecule studies of co hydrogenation over ru/sio2 Journal of Catalysis  1990 123:260-269  DOI:10.1016/0021-9517(90)90174-i
    • Blackmond, D. G., Swid, K. P., Davis, M. E., Gallezot, P. The nature of Rh-CO interactions on SAPO-5-supported Rh Journal of Catalysis  1990 122:247-255  DOI:10.1016/0021-9517(90)90279-s
    • Ciocco, M. V., Blackmond, D. G. Support and alkali promotion effects on the surface-chemistry of nickel silica catalysts Applied Catalysis  1988 44:105-116  DOI:10.1016/s0166-9834(00)80047-0
    • Cavalcanti, F. A. P., Blackmond, D. G., Oukaci, R., Sayari, A., Erdemsenatalar, A., Wender, I. Insitu chemical trapping of CO/H-2 surface species Journal of Catalysis  1988 113:1-12  DOI:10.1016/0021-9517(88)90232-1
    • Kesraoui, S., Oukaci, R., Blackmond, D. G. Adsorption and reaction of CO and H-2 on K-promoted Rh/SIO2 catalysts Journal of Catalysis  1987 105:432-444  DOI:10.1016/0021-9517(87)90071-6
    • Blackmond, D. G., Williams, J. A., Kesraoui, S., Blazewick, D. S. The effects of CS promotion on Rh/Al2O3 catalysts Journal of Catalysis  1986 101:496-504  DOI:10.1016/0021-9517(86)90276-9
    • Blackmond, D. G., Ko, E. I. Carbon-monoxide adsorption as a chemical probe of supported nickel-catalysts - the role of carbonyl formation and support effects Journal of Catalysis  1985 94:343-352  DOI:10.1016/0021-9517(85)90199-x
    • Blackmond, D. G., Ko, E. I. Structural sensitivity of H-2/CO adsorption on Ni/SiO2 catalysts Journal of Catalysis  1985 96:210-221  DOI:10.1016/0021-9517(85)90374-4
    • Blackmond, D. G., Ko, E. I. Preparation and characterization of well-defined Ni/SiO2 catalysts Applied Catalysis  1984 13:49-68  DOI:10.1016/s0166-9834(00)83327-8
    • Blackmond, D. G., Goodwin, J. G., Lester, J. E. Insitu fourier-transform infrared-spectroscopy study of hy cracking catalysts - coke formation and the nature of the active-sites Journal of Catalysis  1982 78:34-43  DOI:10.1016/0021-9517(82)90283-4
    • Blackmond, D. G., Goodwin, J. G. The effect of hydrogen on the adsorption and reaction of 1-Hexene over HY cracking catalysts Journal of Catalysis  1982 78:247-252  DOI:10.1016/0021-9517(82)90304-9
    • Blackmond, D. G., Goodwin, J. G. Zeolite support effects on CO-Ru interactions Journal of the Chemical Society-Chemical Communications  1981 125-126  DOI:10.1039/c39810000125
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Research

research overview

  • Kinetic Methodology. Blackmond has pioneered the development of Reaction Progress Kinetic Analysis (RPKA), a methodology combining highly accurate in-situ data collection with a rigorous mathematical analysis that permits rapid determination of concentration dependences of reactants. In contrast to the classical role of kinetics, in which measurements of concentration dependences most often are asked simply to corroborate a previously proposed mechanism, the Blackmond group’s approach is to employ kinetic studies at the outset of an investigation of ill-defined reaction network to suggest reaction mechanisms. This “kinetic-assisted mechanistic analysis” aids in the design of further supporting experiments including conventional mechanistic tools such as studies of isotope effects and spectroscopic studies for structural and compositional information. One of the most powerful aspects of the methodology is its ability to deconvolute rate processes occurring on the catalytic cycle from those occurring off the cycle. Prominent examples of the application of this methodology to quantitative understanding of complex organic reactions and reaction networks include asymmetric hydrogenation, asymmetric organocatalytic reactions, Pd-catalyzed C-C and C-N bond forming reactions, and transition-metal catalyzed competitive reactions including kinetic resolutions. Reaction Progress Kinetic Analysis finds important application in the pharmaceutical industry, where streamlining process R&D based on Blackmond’s kinetic analysis is becoming an industry-wide standard.

    Nonlinear effects of catalyst enantiopurity. Experimental and theoretical studies in the Blackmond group have derived relationships between catalyst ee and reaction rate that complement the standard tool of studying product ee as a function of catalyst ee. Prof. Blackmond’s work provides a means of testing proposed models for nonlinear effects and expands the power of studies of nonlinear effects to serve as a meaningful mechanistic probe. The concepts developed in this work led Prof. Blackmond to consideration of what has been termed the “ultimate nonlinear effect”, that of the origin of biological homochirality. She carried out the first kinetic studies and developed the first kinetic model exploring the mechanism of asymmetric amplification in the Soai autocatalytic reaction. She continues investigations of this reaction, with current projects focusing on determining the nature of the transition state species in this reaction as well as probing spatiotemporal aspects of absolute asymmetric synthesis by carrying out autocatalysis in well-defined microfluidic reactor networks.

    Biological homochirality and amino acid phase behavior. More recently Prof. Blackmond has expanded the range of models to rationalize the origin of biological homochirality from proposals based purely on chemical reactions to those based on physical phase behavior of chiral molecules as well as a combination of chemical and physical processes. She has demonstrated that highly enantioenriched solutions of amino acids can be produced from nearly racemic mixtures via solution-solid partitioning of the enantiomers. Reactions catalyzed by amino acids that are carried out in such systems show nonlinear product ee consistent with this highly enantioenriched solution composition. This concept was then greatly expanded in scope with the discovery that eutetic compositions could be “tuned” by judicious choice of additives that alter crystal structure and solubility. In sharp contrast to autocatalytic reaction models, which invoke “far-from-equilibrium” behavior, this eutectic model is a pure equilibrium treatment. This distinction has important implications for scenarios concerning the time course over which the evolution of homochirality may have developed.

    Probing the phase behavior of amino acids in conjunction with solution racemization led to separate work showing how one hand of a chiral solid could be transformed completely into its enantiomorph from a nearly racemic mixture of the two. Because interconversion in solution allows an enantiomer that had been part of an L crystal to become part of a D crystal, this has been dubbed the “chiral amnesia” process.
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Teaching

advisees

  • graduate advising relationship

    • Hill, David, Ph.D.  candidate, 2016 -
    • Hawbaker, Neil A, Ph.D.  candidate, 2013 - 2018
    • Mower, Matthew, Ph.D.  candidate, 2013 - 2018
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Background

education and training

  • Ph.D. in Chemical Engineering, Carnegie Mellon University 1984
  • M.S. in Chemical Engineering, University of Pittsburgh 1981
  • B.S. in Chemical Engineering, University of Pittsburgh 1980

awards and honors

  • Distinguished Women in Chemistry or Chemical Engineering, conferred by The International Union of Pure and Applied Chemistry (IUPAC) , 2019
  • Fellow of the American Academy of Arts and Sciences, conferred by American Academy of Arts & Sciences, 2016
  • Chemical Pioneer Award, conferred by American Institute of Chemists, 2016
  • Gabor A. Somorjai Award for Creative Research in Catalysis, conferred by American Chemical Society, 2016
  • Simons Investigator, Collaboration on the Origins of Life, conferred by Simons Foundation, 2013
  • Elected Member, conferred by National Academy of Engineering, 2013
  • Physical Organic Chemistry Award, conferred by Royal Society of Chemistry, 2009
  • Wolfson Research Merit Award, conferred by The Royal Society of London, 2007
  • Arthur C. Cope Scholar Award, conferred by American Chemical Society, 2005
  • Paul Rylander Award, conferred by Organic Reactions Catalysis Society, 2003
  • Royal Society of Chemistry Award in Process Technology, conferred by Royal Society of Chemistry, 2002
  • Paul H. Emmett Award in Fundamental Catalysis, conferred by North American Catalysis Society, 2001
  • Max-Planck-Society Award for Outstanding Women Scientists, conferred by Max Planck Society for the Advancement of Science, 1998
  • Presidential Young Investigator Award, conferred by National Science Foundation, 1985 - 1990
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Contact

full name

  • Donna Blackmond

geographic location

  • Scripps California 

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