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Bates, Robert
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Bates, Robert

Graduate Student
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Positions

  • 2017 - Chief Scientist, GlaxoSmithKline
  • 2016 - Associate Fellow, GlaxoSmithKline
  • 2015 - 2017 Investigator/Program Leader, GlaxoSmithKline
  • 2013 - 2015 Principal Scientist/Program Leader, GlaxoSmithKline
  • 2011 - 2013 Senior Scientist in Tuberculosis DPU, GlaxoSmithKline
  • 2010 - 2011 Postdoctoral Research Associate, Spanish National Research Council
  • 2004 - 2009 Graduate Research Assistant, Scripps Research

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  • Doctoral Dissertation
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Publications

recent publications
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  • academic article

    • Rogacki, M. K., Pitta, E., Balabon, O., Huss, S., Lopez-Roman, E. M., Argyrou, A., Blanco-Ruano, D., Cacho, M., Vande Velde, C. M. L., Augustyns, K., Ballell, L., Barros, D., et al. Identification and profiling of hydantoins - a novel class of potent antimycobacterial DprE1 inhibitors Journal of Medicinal Chemistry  2018 61:11221-11249  DOI:10.1021/acs.jmedchem.8b01356  PMID:30500189
    • Fang, C., Lee, K. K., Nietupski, R., Bates, R. H., Fernandez-Menendez, R., Lopez-Roman, E. M., Guijarro-Lopez, L., Yin, Y., Peng, Z., Gomez, J. E., Fisher, S., Barros-Aguirre, D., et al. Discovery of heterocyclic replacements for the coumarin core of anti-tubercular FadD32 inhibitors Bioorganic & Medicinal Chemistry Letters  2018 28:3529-3533  DOI:10.1016/j.bmcl.2018.09.037  PMID:30316633  PMCID:PMC6233306
    • Smith, P. W., Zuccotto, F., Bates, R. H., Martinez-Martinez, M. S., Read, K. D., Peet, C., Epemolu, O. Pharmacokinetics of β-lactam antibiotics: clues from the past to help discover long-acting oral drugs in the future ACS Infectious Diseases  2018 4:1439-1447  DOI:10.1021/acsinfecdis.8b00160  PMID:30141902  PMCID:PMC6189874
    • Poce, G., Cocozza, M., Alfonso, S., Consalvi, S., Venditti, G., Fernandez-Menendez, R., Bates, R. H., Aguirre, D. B., Ballell, L., De Logu, A., Vistoli, G., Biava, M. In vivo potent BM635 analogue with improved drug-like properties European Journal of Medicinal Chemistry  2018 145:539-550  DOI:10.1016/j.ejmech.2017.12.075  PMID:29335214
    • Machutta, C. A., Kollmann, C. S., Lind, K. E., Bai, X., Chan, P. F., Huang, J., Ballell, L., Belyanskaya, S., Besra, G. S., Barros-Aguirre, D., Bates, R. H., Centrella, P. A., et al. Prioritizing multiple therapeutic targets in parallel using automated DNA-encoded library screening Nature Communications  2017 8  DOI:10.1038/ncomms16081  PMID:28714473  PMCID:PMC5520047
    • Poce, G., Consalvi, S., Cocozza, M., Fernandez-Menendez, R., Bates, R. H., Muro, F. O., Aguirre, D. B., Ballell, L., Biava, M. Pharmaceutical salt of BM635 with improved bioavailability European Journal of Pharmaceutical Sciences  2017 99:17-23  DOI:10.1016/j.ejps.2016.12.003  PMID:27939618
    • Abrahams, K. A., Chung, C. W., Ghidelli-Disse, S., Rullas, J., Rebollo-Lopez, M. J., Gurcha, S. S., Cox, J. A. G., Mendoza, A., Jimenez-Navarro, E., Martinez-Martinez, M. S., Neu, M., Shillings, A., et al. Identification of KasA as the cellular target of an anti-tubercular scaffold Nature Communications  2016 7  DOI:10.1038/ncomms12581  PMID:27581223  PMCID:PMC5025758
    • Pitta, E., Rogacki, M. K., Balabon, O., Huss, S., Cunningham, F., Lopez-Roman, E. M., Joossens, J., Augustyns, K., Ballell, L., Bates, R. H., Van der Veken, P. Searching for new leads for tuberculosis: design, synthesis, and biological evaluation of novel 2-quinolin-4-yloxyacetamides Journal of Medicinal Chemistry  2016 59:6709-6728  DOI:10.1021/acs.jmedchem.6b00245  PMID:27348630
    • Rebollo-Lopez, M. J., Lelievre, J., Alvarez-Gomez, D., Castro-Pichel, J., Martinez-Jimenez, F., Papadatos, G., Kumar, V., Colmenarejo, G., Mugumbate, G., Hurle, M., Barroso, V., Young, R. J., et al. Release of 50 new, drug-like compounds and their computational target predictions for open source anti-tubercular drug discovery PLoS One  2015 10  DOI:10.1371/journal.pone.0142293  PMID:26642067  PMCID:PMC4671658
    • Simal, C., Bates, R. H., Urena, M., Gimenez, I., Koutsou, C., Infantes, L., Fernández de la Pradilla, R., Viso, A. Synthesis of enantiopure 3-hydroxypiperidines from sulfinyl dienyl amines by diastereoselective intramolecular cyclization and 2,3 -sigmatropic rearrangement Journal of Organic Chemistry  2015 80:7674-7692  DOI:10.1021/acs.joc.5b01307  PMID:26162504
    • Ordas, A., Raterink, R. J., Cunningham, F., Jansen, H. J., Wiweger, M. I., Jong-Raadsen, S., Bos, S., Bates, R. H., Barros, D., Meijer, A. H., Vreeken, R. J., Ballell-Pages, L., et al. Testing tuberculosis drug efficacy in a zebrafish high-throughput translational medicine screen Antimicrobial Agents and Chemotherapy  2015 59:753-762  DOI:10.1128/aac.03588-14  PMID:25385118  PMCID:PMC4335901
    • Fernandez de la Pradilla, R., Simal, C., Bates, R. H., Viso, A., Infantes, L. Sulfoxide-directed enantioselective synthesis of functionalized tetrahydropyridines Organic Letters  2013 15:4936-4939  DOI:10.1021/ol402141d  PMID:24063643
    • Poce, G., Bates, R. H., Alfonso, S., Cocozza, M., Porretta, G. C., Ballell, L., Rullas, J., Ortega, F., De Logu, A., Agus, E., La Rosa, V., Pasca, M. R., et al. Improved BM212 MmpL3 inhibitor analogue shows efficacy in acute murine model of tuberculosis infection PLoS One  2013 8  DOI:10.1371/journal.pone.0056980  PMID:23437287  PMCID:PMC3578785
    • Ballell, L., Bates, R. H., Young, R. J., Alvarez-Gomez, D., Alvarez-Ruiz, E., Barroso, V., Blanco, D., Crespo, B., Escribano, J., Gonzalez, R., Lozano, S., Huss, S., et al. Fueling open-source drug discovery: 177 small-molecule leads against tuberculosis ChemMedChem  2013 8:313-321  DOI:10.1002/cmdc.201200428  PMID:23307663  PMCID:PMC3743164
    • Viso, A., Fernandez de la Pradilla, R., Urena, M., Bates, R. H., del Aguila, M. A., Colomer, I. An approach to the stereoselective synthesis of enantiopure dihydropyrroles and aziridines from a common sulfinyl-sulfinamide intermediate Journal of Organic Chemistry  2012 77:525-542  DOI:10.1021/jo202144k  PMID:22088141
    • degree-related publication Bates, R. H., Chen, M., Roush, W. R. Applications of chiral allylmetallating agents toward the synthesis of oxygen heterocycles Current Opinion in Drug Discovery & Development  2008 11:778-792  PMID:18946843
    • degree-related publication Bates, R. H., Shotwell, J. B., Roush, W. R. Stereoselective syntheses of the C(1)-C(9) fragment of amphidinolide C Organic Letters  2008 10:4343-4346  DOI:10.1021/ol801852j  PMID:18783230  PMCID:PMC2650083
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Background

education and training

  • Ph.D. in Chemistry, Scripps Research 2005 - 2009
  • B.S. in Chemistry, Massachusetts Institute of Technology 2000 - 2004

advisee of

  • graduate advising relationship

    • Roush, William, Ph.D.  candidacy, 2006 - 2009
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Contact

full name

  • Robert H. Bates

geographic location

  • Scripps Florida 

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