recent publications
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academic article
- Rogacki, M. K., Pitta, E., Balabon, O., Huss, S., Lopez-Roman, E. M., Argyrou, A., Blanco-Ruano, D., Cacho, M., Vande Velde, C. M. L., Augustyns, K., Ballell, L., Barros, D., et al. Identification and profiling of hydantoins - a novel class of potent antimycobacterial DprE1 inhibitors Journal of Medicinal Chemistry 2018 61:11221-11249 DOI:10.1021/acs.jmedchem.8b01356 PMID:30500189
- Fang, C., Lee, K. K., Nietupski, R., Bates, R. H., Fernandez-Menendez, R., Lopez-Roman, E. M., Guijarro-Lopez, L., Yin, Y., Peng, Z., Gomez, J. E., Fisher, S., Barros-Aguirre, D., et al. Discovery of heterocyclic replacements for the coumarin core of anti-tubercular FadD32 inhibitors Bioorganic & Medicinal Chemistry Letters 2018 28:3529-3533 DOI:10.1016/j.bmcl.2018.09.037 PMID:30316633 PMCID:PMC6233306
- Smith, P. W., Zuccotto, F., Bates, R. H., Martinez-Martinez, M. S., Read, K. D., Peet, C., Epemolu, O. Pharmacokinetics of β-lactam antibiotics: clues from the past to help discover long-acting oral drugs in the future ACS Infectious Diseases 2018 4:1439-1447 DOI:10.1021/acsinfecdis.8b00160 PMID:30141902 PMCID:PMC6189874
- Poce, G., Cocozza, M., Alfonso, S., Consalvi, S., Venditti, G., Fernandez-Menendez, R., Bates, R. H., Aguirre, D. B., Ballell, L., De Logu, A., Vistoli, G., Biava, M. In vivo potent BM635 analogue with improved drug-like properties European Journal of Medicinal Chemistry 2018 145:539-550 DOI:10.1016/j.ejmech.2017.12.075 PMID:29335214
- Machutta, C. A., Kollmann, C. S., Lind, K. E., Bai, X., Chan, P. F., Huang, J., Ballell, L., Belyanskaya, S., Besra, G. S., Barros-Aguirre, D., Bates, R. H., Centrella, P. A., et al. Prioritizing multiple therapeutic targets in parallel using automated DNA-encoded library screening Nature Communications 2017 8 DOI:10.1038/ncomms16081 PMID:28714473 PMCID:PMC5520047
- Poce, G., Consalvi, S., Cocozza, M., Fernandez-Menendez, R., Bates, R. H., Muro, F. O., Aguirre, D. B., Ballell, L., Biava, M. Pharmaceutical salt of BM635 with improved bioavailability European Journal of Pharmaceutical Sciences 2017 99:17-23 DOI:10.1016/j.ejps.2016.12.003 PMID:27939618
- Abrahams, K. A., Chung, C. W., Ghidelli-Disse, S., Rullas, J., Rebollo-Lopez, M. J., Gurcha, S. S., Cox, J. A. G., Mendoza, A., Jimenez-Navarro, E., Martinez-Martinez, M. S., Neu, M., Shillings, A., et al. Identification of KasA as the cellular target of an anti-tubercular scaffold Nature Communications 2016 7 DOI:10.1038/ncomms12581 PMID:27581223 PMCID:PMC5025758
- Pitta, E., Rogacki, M. K., Balabon, O., Huss, S., Cunningham, F., Lopez-Roman, E. M., Joossens, J., Augustyns, K., Ballell, L., Bates, R. H., Van der Veken, P. Searching for new leads for tuberculosis: design, synthesis, and biological evaluation of novel 2-quinolin-4-yloxyacetamides Journal of Medicinal Chemistry 2016 59:6709-6728 DOI:10.1021/acs.jmedchem.6b00245 PMID:27348630
- Rebollo-Lopez, M. J., Lelievre, J., Alvarez-Gomez, D., Castro-Pichel, J., Martinez-Jimenez, F., Papadatos, G., Kumar, V., Colmenarejo, G., Mugumbate, G., Hurle, M., Barroso, V., Young, R. J., et al. Release of 50 new, drug-like compounds and their computational target predictions for open source anti-tubercular drug discovery PLoS One 2015 10 DOI:10.1371/journal.pone.0142293 PMID:26642067 PMCID:PMC4671658
- Simal, C., Bates, R. H., Urena, M., Gimenez, I., Koutsou, C., Infantes, L., Fernández de la Pradilla, R., Viso, A. Synthesis of enantiopure 3-hydroxypiperidines from sulfinyl dienyl amines by diastereoselective intramolecular cyclization and 2,3 -sigmatropic rearrangement Journal of Organic Chemistry 2015 80:7674-7692 DOI:10.1021/acs.joc.5b01307 PMID:26162504
- Ordas, A., Raterink, R. J., Cunningham, F., Jansen, H. J., Wiweger, M. I., Jong-Raadsen, S., Bos, S., Bates, R. H., Barros, D., Meijer, A. H., Vreeken, R. J., Ballell-Pages, L., et al. Testing tuberculosis drug efficacy in a zebrafish high-throughput translational medicine screen Antimicrobial Agents and Chemotherapy 2015 59:753-762 DOI:10.1128/aac.03588-14 PMID:25385118 PMCID:PMC4335901
- Fernandez de la Pradilla, R., Simal, C., Bates, R. H., Viso, A., Infantes, L. Sulfoxide-directed enantioselective synthesis of functionalized tetrahydropyridines Organic Letters 2013 15:4936-4939 DOI:10.1021/ol402141d PMID:24063643
- Poce, G., Bates, R. H., Alfonso, S., Cocozza, M., Porretta, G. C., Ballell, L., Rullas, J., Ortega, F., De Logu, A., Agus, E., La Rosa, V., Pasca, M. R., et al. Improved BM212 MmpL3 inhibitor analogue shows efficacy in acute murine model of tuberculosis infection PLoS One 2013 8 DOI:10.1371/journal.pone.0056980 PMID:23437287 PMCID:PMC3578785
- Ballell, L., Bates, R. H., Young, R. J., Alvarez-Gomez, D., Alvarez-Ruiz, E., Barroso, V., Blanco, D., Crespo, B., Escribano, J., Gonzalez, R., Lozano, S., Huss, S., et al. Fueling open-source drug discovery: 177 small-molecule leads against tuberculosis ChemMedChem 2013 8:313-321 DOI:10.1002/cmdc.201200428 PMID:23307663 PMCID:PMC3743164
- Viso, A., Fernandez de la Pradilla, R., Urena, M., Bates, R. H., del Aguila, M. A., Colomer, I. An approach to the stereoselective synthesis of enantiopure dihydropyrroles and aziridines from a common sulfinyl-sulfinamide intermediate Journal of Organic Chemistry 2012 77:525-542 DOI:10.1021/jo202144k PMID:22088141
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Bates, R. H., Chen, M., Roush, W. R.
Applications of chiral allylmetallating agents toward the synthesis of oxygen heterocycles
Current Opinion in Drug Discovery & Development
2008
11:778-792
PMID:18946843
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Bates, R. H., Shotwell, J. B., Roush, W. R.
Stereoselective syntheses of the C(1)-C(9) fragment of amphidinolide C
Organic Letters
2008
10:4343-4346
DOI:10.1021/ol801852j
PMID:18783230
PMCID:PMC2650083